Neuroimage. Reports最新文献_第4页

The critical role of the basal ganglia in post-stroke fatigue: A pilot study 基底神经节在脑卒中后疲劳中的关键作用：一项初步研究

Q4 Neuroscience

Neuroimage. Reports

Pub Date : 2026-03-01 Epub Date: 2025-12-18 DOI: 10.1016/j.ynirp.2025.100313

Olga Boukrina , John DeLuca , Glenn R. Wylie

This pilot study aimed to explore the neural mechanisms underlying cognitive fatigue (CF) in stroke survivors, with a focus on the role of basal ganglia damage. Sixteen participants were recruited, including six stroke survivors with basal ganglia lesions (BG+), four with lesions elsewhere in the brain (BG−), and six healthy controls (HC). Participants underwent neuropsychological assessments and an fMRI fatigue induction task, where CF was induced using a modified letter-comparison task under individually titrated response deadlines. CF was assessed using the Visual Analog Scale of Fatigue (VAS-F), and fMRI data were analyzed to identify task-evoked activation within the fatigue network. Stroke survivors reported higher levels of CF compared to healthy controls, with the BG+ group exhibiting the highest fatigue levels and the greatest increase in fatigue over time. The BG+ group also demonstrated the most pronounced disparity in reaction times between short and long response deadlines. Functional neuroimaging revealed that CF ratings correlated with task-evoked activation in the fatigue network, but only in the BG− group. Our findings suggest that while stroke presence generally may increase CF, damage specifically involving the basal ganglia accelerates its accrual. Moreover, the ability to engage the fatigue network may mitigate fatigue, as observed in the BG− group. These results underscore the importance of basal ganglia in understanding CF and highlight the need for future research in this area.

本初步研究旨在探讨脑卒中幸存者认知疲劳（CF）的神经机制，重点关注基底神经节损伤的作用。招募了16名参与者，包括6名基底神经节病变（BG+）的中风幸存者，4名大脑其他部位病变（BG -）的中风幸存者和6名健康对照（HC）。参与者接受了神经心理学评估和fMRI疲劳诱导任务，其中CF是在单独滴定的反应截止日期下使用修改的字母比较任务诱导的。使用视觉模拟疲劳量表（VAS-F）评估CF，并分析fMRI数据以确定疲劳网络中的任务诱发激活。与健康对照组相比，中风幸存者报告的CF水平更高，BG+组表现出最高的疲劳水平，随着时间的推移，疲劳程度增加最多。BG+组在短时间和长时间的反应时间上也表现出最明显的差异。功能性神经影像学显示，CF评分与疲劳网络的任务诱发激活相关，但仅在BG -组。我们的研究结果表明，虽然中风通常会增加CF，但特别涉及基底节区的损伤会加速其积累。此外，正如在BG -组中观察到的那样，参与疲劳网络的能力可能会减轻疲劳。这些结果强调了基底神经节在理解CF中的重要性，并强调了该领域未来研究的必要性。

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引用次数: 0

Cerebral plasticity after hypoglosso-facial anastomosis in facial palsy: a magnetoencephalography study 面瘫患者舌下-面部吻合术后大脑可塑性的脑磁图研究

Q4 Neuroscience

Neuroimage. Reports

Pub Date : 2025-12-01 Epub Date: 2025-09-30 DOI: 10.1016/j.ynirp.2025.100294

Rémi Hervochon , Deborah Ziri , Guillaume Dupuch , Maximilien Chaumon , Claire Foirest , Denis Schwartz , Christophe Gitton , Nathalie George , Frédéric Tankere

Background

Hypoglosso-facial anastomosis (HFA) consists in suturing the proximal part of the hypoglossal nerve with the distal part of the facial nerve in patients with facial palsy. Axonal regrowth through the anastomosis makes it possible to restore facial motor skills, which become spontaneous after physiotherapy. This suggests cerebral plasticity.

Objective

We used magnetoencephalography (MEG) in a pilot study to test this hypothesis.

Methods

Twenty-one healthy volunteers (CTRL) and 12 patients after HFA performed 5 motor tasks with MEG and electromyographic recordings: eyelid closure, smile, tongue protraction, mastication and thumb flexion. For each task, we picked the location of the maximum source activity within the precentral gyrus. We calculated the distances between this location and the vertex for each task and a somatotopy index.

Results

There was an interaction between the participant’s group and the task (F(4,124) = 4.07, p = 0.0039). In CTRL, the maximum source location was statistically different between smile and tongue tasks and between eyelid and tongue tasks (p < 0.001). No such difference was observed in HFA (p = 1.000). 90.5 % of CTRL and 41.7 % of HFA showed a normal somatotopy (p = 0.0046).

Conclusions

In CTRL, the organization of the cortical motor areas was similar to that of Penfield’s motor Homunculus. In contrast, in HFA, eyelid closure, tongue protraction and smile areas were not significantly distinct. This supports the hypothesis of cerebral plasticity after HFA.

The Ethical Committee of Paris Idf VI approved the study (CPP Ouest 6-CPP975-HPS2).

背景：面瘫患者舌下神经近端与面神经远端吻合是舌下神经吻合术。通过吻合的轴突再生使恢复面部运动技能成为可能，这些技能在物理治疗后变得自发。这表明大脑具有可塑性。目的在一项初步研究中，我们使用脑磁图（MEG）来验证这一假设。方法21例健康志愿者（对照组）和12例HFA术后患者分别进行闭眼、微笑、伸舌、咀嚼和拇指屈曲5项运动任务的MEG和肌电记录。对于每一项任务，我们在中央前回内选择了最大活动源的位置。我们计算了每个任务的这个位置和顶点之间的距离以及一个躯体解剖指数。结果被试组与任务之间存在交互作用（F(4124) = 4.07, p = 0.0039）。在CTRL中，微笑任务和舌头任务之间以及眼睑任务和舌头任务之间的最大源位置有统计学差异（p < 0.001）。HFA无明显差异（p = 1.000）。90.5%的CTRL和41.7%的HFA显示正常（p = 0.0046）。结论大鼠皮层运动区组织与潘菲尔德运动小丘相似。相比之下，HFA组的闭眼睑、伸舌和微笑区差异不显著。这支持了HFA后大脑可塑性假说。巴黎第六届国际医学论坛伦理委员会批准了该研究（CPP Ouest 6-CPP975-HPS2）。

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引用次数: 0

Temporally parallel facilitation of same-colored objects beyond spatial selection 超越空间选择的同色物体的时间平行化

Q4 Neuroscience

Neuroimage. Reports

Pub Date : 2025-12-01 Epub Date: 2025-11-26 DOI: 10.1016/j.ynirp.2025.100302

S. Wehle, C. Gundlach, M.M. Müller

In a probabilistic spatial cueing experiment, we cued one out of four objects/arcs that were arranged in a circle to test whether the cued arc/object would result in strictly object-based processing restricting facilitation of features to the cued object, or whether we observe global feature-based spread across object boundaries. Four arcs flickered at different frequencies, respectively, to evoke steady state visual evoked potentials (SSVEPs), allowing to investigate neural temporal dynamics in the early visual cortex following the presentation of the spatial cue. Initially, all arcs had identical colors and with spatial cue onset switched to a specific color configuration. In one configuration, one uncued arc had the same color as the cued one. We found global feature-based spread to same-colored elements across object boundaries in SSVEPs and behavioral responses. Once spatial attention was shifted to the cued location/arc, SSVEP amplitudes elicited by the cued arc and the same-colored uncued arc showed a temporally overlapping increase early after the spatial cue. Importantly, color processing was not required to perform the task, indicating that global feature-based spread occurs automatically, independent of task demands.

在一个概率空间线索实验中，我们对排列成一个圆圈的四个物体/弧线中的一个进行了线索，以测试线索弧线/物体是否会导致严格的基于物体的处理，限制特征对线索物体的促进，或者我们是否观察到基于物体边界的全局特征传播。四个弧分别以不同的频率闪烁，以唤起稳态视觉诱发电位（ssvep），从而研究空间线索呈现后早期视觉皮层的神经时间动态。最初，所有的弧线都有相同的颜色，随着空间线索的开始，它们会切换到特定的颜色配置。在一种配置中，一条未提示的弧与提示的弧具有相同的颜色。我们发现，在ssvep和行为反应中，基于全局特征的传播跨越对象边界到相同颜色的元素。当空间注意力转移到提示位置/弧线时，提示弧线和相同颜色的未提示弧线引起的SSVEP振幅在空间提示后早期出现了时间重叠的增加。重要的是，执行任务不需要颜色处理，这表明基于特征的全局扩展自动发生，独立于任务需求。

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引用次数: 0

Altered white matter connection from the locus coeruleus to the thalamus in Parkinson's disease 帕金森氏症中蓝斑与丘脑白质连接的改变

Q4 Neuroscience

Neuroimage. Reports

Pub Date : 2025-12-01 Epub Date: 2025-09-25 DOI: 10.1016/j.ynirp.2025.100292

M.G. Wanders , J.F.A. Jansen , A.F. Wolters , M. Heijmans , Y. Temel , M.L. Kuijf , S.M.A. Michielse

Background

Parkinson's disease (PD) is the fastest growing neurodegenerative movement disorder. It is characterized by both motor and non-motor, including neuropsychiatric disturbances such as depression and anxiety. The locus coeruleus (LC), a small nucleus in the brainstem, plays a key role in these symptoms and has white matter connections to the thalamus. This study aims to investigate this LC-thalamic tract in PD patients using ultra-high-field diffusion-weighted imaging (DWI) and to examine its relationship with non-motor symptoms.

Methods

100 participants, including 69 early-stage PD and 31 healthy control (HC) participants were evaluated using several questionnaires and a 7T diffusion MRI scan. Tractography was performed to reconstruct the LC-thalamic white matter tract, and diffusion parameters (FA, MD, AD, RD) were analysed.

Results

PD patients showed significantly higher mean diffusivity (MD) and axial diffusivity (AD) in the white matter tissue compared to HC, indicating reduced white matter integrity.

Discussion

This study shows the feasibility to visualize the LC-thalamic tract with the use of 7T DWI data. The results provide evidence of the association between the integrity of the white matter tracts and early PD development, highlighting its potential as a target for therapeutic interventions. Further research is needed to elucidate the role of the LC and its white matter connections in the progression of PD and neuropsychiatric and other symptoms.

帕金森病（PD）是发展最快的神经退行性运动障碍。它的特点是运动和非运动，包括神经精神障碍，如抑郁和焦虑。蓝斑核（LC）是脑干中的一个小核，在这些症状中起关键作用，它与丘脑有白质连接。本研究旨在利用超高场弥散加权成像（DWI）研究PD患者的lc -丘脑束，并探讨其与非运动症状的关系。方法采用问卷调查和7T弥散MRI扫描对100例PD患者进行评价，其中早期PD 69例，健康对照31例。采用神经束造影重建丘脑-下丘脑白质束，分析扩散参数（FA、MD、AD、RD）。结果spd患者的白质组织平均弥漫性（MD）和轴向弥漫性（AD）明显高于HC，表明白质完整性降低。本研究显示了利用7T DWI数据可视化丘脑束的可行性。该结果为白质束完整性与早期PD发展之间的关联提供了证据，突出了其作为治疗干预目标的潜力。需要进一步的研究来阐明LC及其白质连接在PD和神经精神及其他症状进展中的作用。

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引用次数: 0

Resting-state functional connectivity changes in the human brain from electrically-stimulated (2 Hz), rhythmic muscle contractions to the hand: An exploratory study 静息状态下人类大脑从电刺激（2hz）、有节奏的肌肉收缩到手部的功能连接变化：一项探索性研究

Q4 Neuroscience

Neuroimage. Reports

Pub Date : 2025-12-01 Epub Date: 2025-12-02 DOI: 10.1016/j.ynirp.2025.100303

William T. Stauber , Tyler McGaughey , Nick Evans , Sean Snyder , Julie A. Brefczynski-Lewis , James W. Lewis

Sensory nerves from contracting skeletal muscles can alter autonomic functions mediated by connections in the medulla and hypothalamus. We hypothesized that low-frequency, non-voluntary, rhythmical electrical stimulation of small muscles of the hand, in contrast to continuous sensory stimulation of the overlying skin, will change functional connectivity in the brain revealing specific regions of the muscle afferent–pituitary axis. Using a 2x2 design, eight healthy young participants underwent resting-state functional magnetic resonance imaging (rsfMRI) immediately before and after a 45-min electrical stimulation session with 2 Hz to the left hand muscles and a counterbalanced session with continuous 100 Hz skin stimulation to the same region. Using standardized CONN toolbox software, functional connectivity data were analyzed. Rhythmic muscle stimulation led to significant differences in connectivity associated with the autonomic and limbic systems such as the hypothalamus, amygdala, periaqueductal gray, thalamus, basal ganglia, plus insulae and cingulate cortices. In addition, the muscle stimulation led to changes in several resting state networks. Importantly, using a tightly controlled 2x2 rsfMRI design, the different stimulation protocols were applied to each subject (within-subject design), which led to significant differences in patterns of functional connectivity changes after the muscle versus skin stimulation conditions with only a small number of participants. In conclusion, significant differences in brain networks involving autonomic and limbic systems were activated by using low-frequency, rhythmical stimulation of small hand muscles. In contrast to skin electrical stimulation, which primarily entailed exteroceptive input, muscle electrical stimulation significantly engaged neural networks implicated in interoception, including the insula and hypothalamus.

骨骼肌收缩的感觉神经可以改变髓质和下丘脑连接介导的自主神经功能。我们假设，对手部小肌肉进行低频、非自愿、有节奏的电刺激，与对其上的皮肤进行持续的感觉刺激相反，将改变大脑中显示肌肉传入-垂体轴特定区域的功能连接。采用2x2设计，8名健康的年轻参与者在对左手肌肉进行45分钟的2赫兹电刺激和对同一区域进行连续100赫兹皮肤刺激的平衡时段之前和之后立即进行静息状态功能磁共振成像（rsfMRI）。使用标准化的CONN工具箱软件，对功能连接性数据进行分析。节律性肌肉刺激导致自主神经系统和边缘系统（如下丘脑、杏仁核、导水管周围灰质、丘脑、基底神经节以及脑岛和扣带皮层）连通性的显著差异。此外，肌肉刺激导致几个静息状态网络的变化。重要的是，使用严格控制的2x2 rsfMRI设计，不同的刺激方案应用于每个受试者（受试者内设计），这导致少量参与者在肌肉和皮肤刺激条件下功能连接变化模式的显着差异。综上所述，通过对手部小肌肉进行低频、有节奏的刺激，可以激活涉及自主神经系统和边缘系统的大脑网络。与皮肤电刺激不同的是，皮肤电刺激主要涉及外感受输入，而肌肉电刺激则主要涉及与内感受有关的神经网络，包括脑岛和下丘脑。

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引用次数: 0

Relaxation-compensated chemical exchange saturation transfer MRI in the cervical spinal cord at 3T: An application in multiple sclerosis 3T颈脊髓弛豫补偿化学交换饱和转移MRI：在多发性硬化症中的应用

Q4 Neuroscience

Neuroimage. Reports

Pub Date : 2025-12-01 Epub Date: 2025-10-25 DOI: 10.1016/j.ynirp.2025.100298

Alicia E. Cronin , Anna Combes , Grace Sweeney , Logan Prock , Delaney Houston , Isabella Stuart , Seth Stubblefield , Colin D. McKnight , Francesca Bagnato , Kristin P. O'Grady , Seth A. Smith

Multiple sclerosis (MS) is an autoimmune disease affecting the central nervous system, characterized by demyelination. Exploring pathological changes in the spinal cord could improve our understanding of the mechanisms that cause neurological dysfunction and clinical symptoms; however, conventional MRI is not sensitive to molecular changes within the tissue. Chemical exchange saturation transfer (CEST) can probe tissue biochemistry with high resolution and sensitivity, without exogenous contrasts. However, CEST measurements in vivo are contaminated by concurrent effects including semi-solid magnetization transfer (MT), direct water saturation, and T1-relaxation, which can be altered in MS and need to be removed to accurately quantify changes. Fifty-three people with relapsing-remitting MS (pwRRMS) and 45 healthy controls (HCs) were imaged at 3 T to quantify amide and nuclear Overhauser enhancement (NOE) CEST effects in the cervical spinal cord. Using Lorentzian fitting, confounding effects were removed, and the apparent exchange-dependent relaxation (AREX) contrast was calculated. Uncorrected and corrected AREX amide and NOE contrasts were compared across groups and tissue types. In pwRRMS, AREX NOE was significantly different in lesions compared to normal-appearing white matter. Greater heterogeneity in both CEST contrasts was observed in pwRRMS compared to the HCs. In a sub-analysis of pwRRMS separated by neurological disability, AREX amide was significantly different between pwRRMS with and without disability. The correction of confounding factors in this study highlights the importance of isolating CEST effects in the cervical spinal cord for more specific characterization and to better understand changes in tissue pathology and relationship to disease severity.

多发性硬化症（MS）是一种影响中枢神经系统的自身免疫性疾病，以脱髓鞘为特征。探索脊髓的病理变化可以提高我们对引起神经功能障碍和临床症状的机制的理解；然而，传统的MRI对组织内的分子变化并不敏感。化学交换饱和转移（CEST）可以在不需要外源对比的情况下，以高分辨率和高灵敏度探测组织生化。然而，体内CEST测量受到半固体磁化转移（MT）、直接水饱和度和t1弛豫等并发效应的污染，这些效应在质谱中可以改变，需要去除以准确量化变化。53例复发缓解型多发性硬化症患者（pwRRMS）和45例健康对照（hc）在3t下进行成像，以量化颈脊髓的酰胺和核Overhauser增强（NOE） CEST效应。利用洛伦兹拟合去除混杂效应，计算表观交换相关松弛（AREX）对比。不同组和不同组织类型比较未校正和校正的AREX酰胺和NOE的对比。在pwRRMS中，AREX NOE在病变中与正常白质相比有显著差异。与hc相比，pwRRMS在两种CEST对比中观察到更大的异质性。在以神经功能障碍分开的pwRRMS的亚分析中，AREX酰胺在有和没有残疾的pwRRMS之间有显著差异。本研究中对混杂因素的纠正强调了分离CEST在颈脊髓中的作用的重要性，以获得更具体的表征，并更好地了解组织病理学的变化及其与疾病严重程度的关系。

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引用次数: 0

Glymphatic system dysfunction associated with player position in collegiate American football players: A DTI-ALPS study 美国大学橄榄球运动员体位与淋巴系统功能障碍相关：一项DTI-ALPS研究

Q4 Neuroscience

Neuroimage. Reports

Pub Date : 2025-12-01 Epub Date: 2025-10-16 DOI: 10.1016/j.ynirp.2025.100295

Michael Gay , Xiaoxiao Bai , Owen Griffith , Linda Papa , Wayne Sebastianelli , Kevin Cockroft , Krishnamoorthy Thamburaj , Semyon Slobounov

Purpose

The glymphatic system plays a crucial role in both short-term and long-term brain health through the clearance of neural waste and is vulnerable to disruption following head trauma. This study aimed to determine whether exposure to a season of sub-clinical head acceleration events (HAEs) in collegiate American football affects glymphatic function, and whether this effect varies by player position or concussion history.

Methods

Sixty-six male NCAA Division I football athletes underwent diffusion tensor imaging (DTI) before and after a competitive football season. Glymphatic function was quantified using the Diffusion Tensor Imaging Along the Perivascular Space (DTI-ALPS) index. Participants were categorized by player position (Speed vs. Non-Speed) and concussion history (Yes vs. No). Linear mixed-effects models were used to evaluate changes in DTI-ALPS index by time point, hemisphere, position, and concussion history.

Results

There were no significant changes in DTI-ALPS values from pre-to post-season in either hemisphere across the full cohort. However, a significant main effect of player position was observed in the right hemisphere (p = 0.025), with Speed position players demonstrating lower DTI-ALPS indices compared to Non-Speed players, suggesting reduced glymphatic function. No significant effects of concussion history or interaction terms were found.

Conclusions

These findings indicate that positional differences in HAEs experienced by Speed players, even absent clinical concussion, may contribute to impaired glymphatic function. Speed position players may be at increased risk due to the nature and magnitude of head impacts. The DTI-ALPS index may serve as a sensitive biomarker for early, sub-clinical brain dysfunction in athletes participating in contact sports.

目的淋巴系统通过清除神经废物在短期和长期脑健康中起着至关重要的作用，并且在头部创伤后容易受到破坏。本研究旨在确定一个赛季的美国大学橄榄球亚临床头部加速事件（HAEs）是否会影响淋巴功能，以及这种影响是否因球员位置或脑震荡病史而异。方法采用弥散张量成像（diffusion tensor imaging， DTI）技术对66名男子NCAA一级联赛足球运动员在比赛前后进行影像学检查。采用沿血管周围间隙弥散张量成像（DTI-ALPS）指数量化淋巴功能。参与者按球员位置（速度vs.非速度）和脑震荡历史（是vs.否）进行分类。采用线性混合效应模型评价DTI-ALPS指数在时间点、半球、体位和脑震荡病史方面的变化。结果在整个队列中，两个半球的DTI-ALPS值从赛季前到赛季后都没有显著变化。然而，在右半球观察到球员位置的显著主要影响（p = 0.025），与非速度球员相比，速度球员表现出较低的DTI-ALPS指数，表明淋巴功能降低。没有发现脑震荡病史或相互作用条件的显著影响。结论：即使没有临床脑震荡，Speed球员的HAEs位置差异也可能导致淋巴功能受损。由于头部撞击的性质和程度，速度位置球员可能会面临更高的风险。DTI-ALPS指数可作为接触性运动运动员早期亚临床脑功能障碍的敏感生物标志物。

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引用次数: 0

Exploring brain activation during a buttoning task in adults: A functional near infrared spectroscopy investigation 在成人扣钮扣任务中探索大脑活动：功能性近红外光谱研究

Q4 Neuroscience

Neuroimage. Reports

Pub Date : 2025-12-01 Epub Date: 2025-11-20 DOI: 10.1016/j.ynirp.2025.100300

Niloufar Benam , Courtney Pollock , Jill G. Zwicker , Shannon B. Lim , Kaya Yoshida , Julia Schmidt

The ability to complete activities of daily living (ADLs) is an important part of daily life and can promote well-being and independence. There is currently limited knowledge of brain activity during ADLs (e.g. dressing tasks). Previous studies explored brain activity during dressing using functional magnetic resonance imaging (fMRI); however, the supine position during fMRI is not a natural dressing posture and may impact findings. Functional near-infrared spectroscopy (fNIRS) is a promising method of data collection as it can investigate brain activity in a natural state (sitting) during dressing. In this study, to understand brain activity during buttoning in unimpaired adults, twenty participants (25–65 years) completed an upper extremity task of buttoning in three 20 s repetitions with 15 s rest in between each activity block. Brain activation patterns were recorded using fNIRS over the prefrontal, premotor, supplementary motor, sensorimotor, and posterior parietal cortices. Compared to the resting period, significantly higher activation during the activity block was observed in all recorded regions but the posterior parietal cortex. Understanding brain activity in unimpaired adults during the performance of activities of daily living is a critical first-step for investigating brain activation in different clinical populations.

完成日常生活活动（ADLs）的能力是日常生活的重要组成部分，可以促进幸福感和独立性。目前对adl期间大脑活动的了解有限（例如穿衣任务）。先前的研究利用功能性磁共振成像（fMRI）探索了包扎过程中的大脑活动；然而，在功能磁共振成像中，仰卧位不是自然的穿衣姿势，可能会影响结果。功能近红外光谱（fNIRS）是一种很有前途的数据收集方法，因为它可以研究穿衣时自然状态下（坐着）的大脑活动。在这项研究中，为了了解未受损成人扣纽扣时的大脑活动，20名参与者（25-65岁）完成了上肢扣纽扣任务，在每个活动块之间休息15秒，重复3次，每次20秒。使用fNIRS记录前额叶、前运动、辅助运动、感觉运动和后顶叶皮层的大脑激活模式。与静息期相比，在活动阻滞期间，除后顶叶皮质外，所有记录的区域都观察到明显更高的激活。了解正常成年人在日常生活活动中的脑活动是研究不同临床人群脑活动的关键的第一步。

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引用次数: 0

Subcortical resting state functional connectivity as a neural marker of first onset internalizing disorder in high-risk youth 皮层下静息状态功能连通性作为高危青少年首次发病内化障碍的神经标志物

Q4 Neuroscience

Neuroimage. Reports

Pub Date : 2025-12-01 Epub Date: 2025-09-26 DOI: 10.1016/j.ynirp.2025.100291

McKinley Pawlak , Signe Bray , Ford Burles , Daniel C. Kopala-Sibley

Background

Research has linked individual differences in resting state functional connectivity (RSFC) of subcortical brain regions to internalizing disorders, but little research has examined if these changes are pre-morbid risk factors. This study examined individual differences in subcortical RSFC as risk factors for the first lifetime onset of an internalizing disorder in youth at familial risk.

Methods

Participants (n = 93) were adolescents with a parental history of internalizing disorders, but with no such history themselves. Youth completed resting state fMRI scans, as well as the MINI-Kid and the Youth Self Report internalizing symptoms scale at baseline. The MINI-Kid was completed again at 9 or 18-month follow-up to assess onset of internalizing disorders. Seed-to-whole brain analyses consisted of a multiple regression models controlling for sex, age, in scanner motion, and baseline symptoms.

Results

First onsets at follow-up were associated with increased baseline RSFC between the left caudate and the bilateral SMA (pFDR = .002), and between the right nucleus accumbens and the right superior parietal lobule (pFDR = .0003).

Conclusion

Altered RSFC of subcortical regions may represent a pre-morbid risk factor for developing a first onset of an internalizing disorder. Results may have implications for understanding the neural bases of internalizing disorders and for early identification and prevention efforts.

研究已经将皮质下脑区域静息状态功能连接（RSFC）的个体差异与内化障碍联系起来，但很少有研究检查这些变化是否为发病前的危险因素。本研究考察了皮质下RSFC的个体差异作为具有家族风险的青少年首次终身发病的内化障碍的危险因素。方法研究对象（n = 93）为父母有内化障碍史，但自身无内化障碍史的青少年。青少年完成静息状态fMRI扫描，以及MINI-Kid和青少年自我报告内化症状量表。MINI-Kid在9或18个月的随访中再次完成，以评估内化障碍的发生。从种子到全脑的分析包括控制性别、年龄、扫描运动和基线症状的多重回归模型。结果随访时首次发病与左尾状核和双侧SMA之间（pFDR = 0.002）以及右侧伏隔核和右侧顶叶上小叶之间（pFDR = 0.0003）的基线RSFC增加有关。结论皮质下区域RSFC的改变可能是发病前发生内化障碍的危险因素。结果可能对了解内化障碍的神经基础以及早期识别和预防工作具有启示意义。

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引用次数: 0

Test-retest reliability of edge-level resting-state functional connectivity in people with aphasia 失语症患者静息状态功能连通性的重测信度

Q4 Neuroscience

Neuroimage. Reports

Pub Date : 2025-12-01 Epub Date: 2025-10-22 DOI: 10.1016/j.ynirp.2025.100296

Jeffrey P. Johnson , Michael Walsh Dickey , Jason W. Bohland , William D. Hula

There is a growing interest in using resting-state functional connectivity (RSFC) to investigate language processing and recovery in post-stroke aphasia due to its limited dependence on an individual's ability to follow directions and perform tasks, or the severity of their aphasia. However, the test-retest reliability of RSFC in people with aphasia has not been established, raising questions about the strength and validity of inferences based on this technique. In this study, we examined the reliability of RSFC at the level of individual edges (i.e., connections) in 14 adults with chronic aphasia due to left-hemisphere stroke. Intraclass correlations (ICCs) between two resting-state scans obtained over a few days were computed for every edge in a whole-brain network and several cognitive and language subnetworks. Based on median ICCs, reliability was fair at longer scan durations (10–12 min) and better in most subnetworks than the whole brain. Reliability was also positively associated with connectivity strength and had a weak negative relationship with inter-node distance (i.e., the distance between the regions that form an edge). Edges in the right hemisphere were more reliable than those in the left hemisphere and between hemispheres, though all three sets of edges were fairly reliable. The results indicate that edge-level RSFC is acceptably reliable for continued use in aphasia research but highlight the need for strategies to ensure that inferences are based on valid results, such as using sufficiently long scans and focusing analyses on established subnetworks, especially in longitudinal contexts.

静息状态功能连接（RSFC）用于研究脑卒中后失语症的语言处理和恢复，这是由于其对个体遵循指示和执行任务的能力的有限依赖，或者失语症的严重程度。然而，失语症患者RSFC的重测信度尚未建立，这对基于该技术的推断的强度和有效性提出了质疑。在这项研究中，我们在个体边缘（即连接）水平上检测了14例左半球中风导致的慢性失语症患者的RSFC的可靠性。在几天内获得的两次静息状态扫描之间的类内相关性（ICCs）被计算为全脑网络和几个认知和语言子网络的每个边缘。基于中位ICCs，可靠性在较长的扫描持续时间（10-12分钟）是公平的，并且在大多数子网络中比在整个大脑中更好。可靠性还与连通性强度呈正相关，与节点间距离（即形成边缘的区域之间的距离）呈弱负相关。右半球的边缘比左半球和两个半球之间的边缘更可靠，尽管这三组边缘都相当可靠。结果表明，边缘水平RSFC在失语症研究中继续使用是可接受的可靠的，但强调需要策略来确保推论是基于有效的结果，例如使用足够长的扫描和集中分析已建立的子网，特别是在纵向背景下。

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引用次数: 0