Neuroimage. Reports最新文献_第7页

Automated landmark-based symmetric and standard alignment of skull base structures on CT 基于地标的颅底结构在CT上的对称和标准自动对齐

Q4 Neuroscience

Neuroimage. Reports

Pub Date : 2025-04-04 DOI: 10.1016/j.ynirp.2025.100260

Justin A. Cramer , Trevor Huff , Sean Kelly , Daniel Welch , Devin DeLuna , Conner Beyersdorf , Robin High , Matthew White

Introduction

Symmetry and standard alignment are crucial in both clinical interpretation and research on head CT studies. Registration to a standard template is the traditional method for alignment, yet registration does not guarantee precise alignment of any given structure. This study introduces a method for aligning skull base structures while still achieving a standard anterior commissure-posterior commissure (AC-PC)-like orientation on head CT studies using landmarks, specifically the cochleas and nasal bridge.

Methods

A retrospective study was conducted using head CTs from various General Electric scanners. Landmarks were manually annotated, and a 3D U-Net was trained for landmark identification. Landmark-based alignment was then performed on a test dataset and assessed in two different ways: whole head and skull base alignment. Whole head alignment was assessed quantitatively by expert review. Skull base alignment was then assessed at the cochleas, comparing their alignment between this landmark-based technique and registration to a template.

Results

This landmark-based technique significantly improved whole head and skull base alignment of head CT studies. Whole head alignment reduced average deviations of 5, 11, and 4° in the axial, sagittal, and coronal planes to 1, 5, and 2° respectively. Meanwhile, skull base alignment assessed via the cochlea was also improved relative to traditional registration. For the landmark technique, the cochleas were deviated from perfect by a mean of 0.552 and 0.511 mm along the y and z axes compared to 2.110 and 2.506 mm with registration.

Conclusion

This study demonstrates a simple landmark-based technique for aligning the cochleas on head CT studies while approximating whole head AC-PC orientation, which has applications in both clinical and research settings, particularly for studies focused on the skull base.

对称和标准对齐在临床解释和头部CT研究中都是至关重要的。注册到标准模板是传统的对齐方法，但是注册不能保证任何给定结构的精确对齐。本研究介绍了一种对齐颅底结构的方法，同时在头部CT研究中使用地标，特别是耳蜗和鼻桥，仍能获得标准的前交合-后连合（AC-PC）样方向。方法采用不同型号通用电气扫描仪的头部ct进行回顾性研究。人工标注地标，并训练三维U-Net进行地标识别。然后在测试数据集上执行基于地标的校准，并以两种不同的方式进行评估：整个头部和颅底校准。通过专家评审对全头对准进行定量评价。然后在耳蜗上评估颅底对齐，比较这种基于地标的技术和模板注册之间的对齐。结果这种基于地标的技术显著改善了头部CT研究的全头和颅底对齐。整个头部对准将轴位、矢状面和冠状面的平均偏差分别减少了5°、11°和4°，分别减少到1°、5°和2°。同时，通过耳蜗评估的颅底对齐也比传统的配准得到了改进。与配准法的2.110和2.506 mm相比，标记法的耳蜗沿y轴和z轴偏离完美的平均值分别为0.552和0.511 mm。本研究展示了一种简单的基于地标的技术，可以在头部CT研究中对准耳蜗，同时接近整个头部的AC-PC方向，这在临床和研究环境中都有应用，特别是在颅底的研究中。

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引用次数: 0

Non-invasive brain stimulation reorganises effective connectivity during a working memory task in individuals with Neurofibromatosis Type 1 非侵入性脑刺激重组1型神经纤维瘤病患者工作记忆任务期间的有效连接

Q4 Neuroscience

Neuroimage. Reports

Pub Date : 2025-03-29 DOI: 10.1016/j.ynirp.2025.100258

Marta Czime Litwińczuk , Shruti Garg , Stephen R. Williams , Jonathan Green , Caroline Lea-Carnall , Nelson J. Trujillo-Barreto

Introduction

In a previous study, we examined the effect of atDCS on working memory task performance and modulation of the inhibitory neurotransmitter, gamma-aminobutyric acid (GABA), in the dorsolateral prefrontal cortex (dlPFC). The present study investigates whether tDCS modulates effective connectivity during the task, specifically assessing whether tDCS alters interactions between neuronal populations.

Methods

Eighteen adolescents with Neurofibromatosis Type 1 (NF1) completed a single-blind sham-controlled cross-over randomised tDCS trial (with the anode at F3 and cathode at Cz). Dynamic causal modelling was used to estimate the effective connectivity between regions that showed working memory effects from the fMRI. Group-level inferences for between sessions (pre- and post-stimulation) and stimulation type (tDCS and sham) effects were carried out using the parametric empirical Bayes approach. A correlation analysis was performed to relate the estimated effective connectivity parameters of left dlPFC pre-tDCS and post-tDCS to the concentration of GABA measured via magnetic resonance spectroscopy (MRS-GABA). Next, correlation analysis was repeated using all working memory performance and all pre-tDCS and post-tDCS connectivity parameters.

Results

It was found that tDCS decreased average excitatory connectivity from dlPFC to left superior frontal gyrus and increased average excitatory connectivity to left globus pallidus. Further, reduced average intrinsic (inhibitory) connectivity of left dlPFC was associated with lower MRS-GABA. However, none of the connectivity parameters of dlPFC showed any association with performance on a working memory task.

Conclusions

These findings suggest that tDCS reorganised connectivity from frontal to fronto-striatal connectivity. As tDCS-related changes were not specific to the effect of working memory, they may have impacted general cognitive control processes. In addition, by reducing MRS-GABA, tDCS might make dlPFC more sensitive and responsive to external stimulation, such as performance of cognitive tasks.

在之前的一项研究中，我们研究了atDCS对工作记忆任务表现的影响以及背外侧前额皮质（dlPFC）中抑制性神经递质γ -氨基丁酸（GABA）的调节。本研究调查了tDCS是否在任务过程中调节有效的连接，特别是评估tDCS是否改变神经元群体之间的相互作用。方法18例青少年1型神经纤维瘤病（NF1）患者完成了单盲假对照交叉随机tDCS试验（阳极F3，阴极Cz）。动态因果模型用于估计从功能磁共振成像中显示工作记忆效应的区域之间的有效连通性。使用参数经验贝叶斯方法对会话之间（刺激前和刺激后）和刺激类型（tDCS和假性）效应进行组水平推断。通过磁共振波谱法（MRS-GABA）测定的GABA浓度与tdcs前后左dlPFC有效连接参数的相关性分析。接下来，使用所有工作记忆性能和所有tdcs前和tdcs后连接参数重复相关分析。结果tDCS降低了左额上回的平均兴奋性连通性，增加了左苍白球的平均兴奋性连通性。此外，左侧dlPFC平均内在（抑制性）连通性的降低与MRS-GABA的降低有关。然而，dlPFC的连接参数都没有显示出与工作记忆任务的表现有任何关联。结论tDCS重组了从额叶到额纹状体的连接。由于tdcs相关的变化并不特定于工作记忆的影响，它们可能影响了一般的认知控制过程。此外，通过减少MRS-GABA， tDCS可能使dlPFC对外部刺激更加敏感和反应，例如认知任务的表现。

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引用次数: 0

Innovative biomarker exploration in ASD: Combining Graph Neural Networks and permutation testing on fMRI data ASD的创新生物标志物探索：结合图神经网络和fMRI数据的排列测试

Q4 Neuroscience

Neuroimage. Reports

Pub Date : 2025-03-26 DOI: 10.1016/j.ynirp.2025.100249

Donglin Wang, Wandi Ding

This study employed Graph Neural Networks (GNNs), specifically an unsupervised GNN, to extract node embeddings from brain regions in both Autism Spectrum Disorder (ASD) and control groups. The objective was to identify potential biomarkers by analyzing node embeddings extracted from a graph model based on functional Magnetic Resonance Imaging (fMRI) data. Permutation tests were conducted to identify regions with significant differences in their embeddings between the two groups. Our results revealed several regions exhibiting significant differences, including the cerebellum, temporal lobe, and occipital lobe. These findings align with previous studies on ASD. Moreover, novel regions such as Vermis_3, Vermis_4_5, Fusiform areas, Parietal, and Cuneus were identified, emphasizing the need for further investigation. This study underscores the potential of GNNs in analyzing brain networks for ASD biomarker discovery. The identified regions warrant additional validation and exploration to understand their association with specific domains of ASD symptoms. Our approach presents a promising avenue to advance the diagnosis of ASD and to improve our understanding of its underlying neural basis.

本研究采用图神经网络（GNN），特别是一种无监督的GNN，从自闭症谱系障碍（ASD）和对照组的大脑区域提取节点嵌入。目的是通过分析从基于功能磁共振成像（fMRI）数据的图模型中提取的节点嵌入来识别潜在的生物标志物。进行排列测试以确定两组之间嵌入的显著差异区域。我们的结果显示了几个区域表现出显著的差异，包括小脑、颞叶和枕叶。这些发现与之前对自闭症谱系障碍的研究一致。此外，还发现了新发现的Vermis_3、Vermis_4_5、Fusiform、Parietal和Cuneus等区域，需要进一步研究。这项研究强调了gnn在分析脑网络以发现ASD生物标志物方面的潜力。已确定的区域需要进一步验证和探索，以了解它们与特定ASD症状域的关联。我们的方法为推进ASD的诊断和提高我们对其潜在神经基础的理解提供了一条有希望的途径。

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引用次数: 0

Functional redundancy of the posterior hippocampi is selectively disrupted in non-demented older adults with β-amyloid deposition 非痴呆老年人海马后部功能冗余选择性破坏β-淀粉样蛋白沉积

Q4 Neuroscience

Neuroimage. Reports

Pub Date : 2025-03-23 DOI: 10.1016/j.ynirp.2025.100255

Jenna K. Blujus , Michael W. Cole , Elena K. Festa , Stephen L. Buka , Stephen P. Salloway , William C. Heindel , Hwamee Oh , the Alzheimer's Disease Neuroimaging Initiative

Several neural mechanisms underlying resilience to Alzheimer's disease (AD) have been proposed, including redundant neural connections between the posterior hippocampi and all other brain regions, and global functional connectivity of the left frontal cortex (LFC). Here, we investigated if functional redundancy of the hippocampus (HC) and LFC underscores neural resilience in the presence of early AD pathologies. From the ADNI database, cognitively normal older adults (CN) (N = 220; 36 % Aβ+) and patients with Mild Cognitive Impairment (MCI) (N = 143; 51 % Aβ+) were utilized. Functional redundancy was calculated from resting state fMRI data using a graph theoretical approach by summing the direct and indirect paths (path lengths = 1–4) between each region of interest and its 263 functional connections. Posterior HC, but not anterior HC or LFC, redundancy was significantly lower in Aβ+ than Aβ-groups, regardless of diagnosis. Posterior HC redundancy related to higher education and better episodic memory, but it did not moderate the Aβ-cognition relationships across the diagnostic groups. Together, these findings suggest that posterior HC redundancy captures network disruption that parallels selective vulnerability to Aβ deposition. Further, our findings indicate that functional redundancy may underscore a network metric different from global functional connectivity of the LFC.

已经提出了几种潜在的阿尔茨海默病（AD）恢复力的神经机制，包括海马体后部和所有其他大脑区域之间的冗余神经连接，以及左额叶皮质（LFC）的全球功能连接。在这里，我们研究了海马体（HC）和LFC的功能冗余是否强调了早期AD病理存在的神经弹性。从ADNI数据库中，认知正常老年人（CN） (N = 220；36% Aβ+)和轻度认知障碍（MCI）患者(N = 143；51% Aβ+)。通过将每个感兴趣的区域与其263个功能连接之间的直接和间接路径（路径长度= 1-4）相加，使用图理论方法从静息状态fMRI数据中计算功能冗余。无论诊断如何，Aβ+组的后HC，而不是前HC或LFC，冗余度显著低于Aβ-组。后验HC冗余与高等教育和更好的情景记忆有关，但它没有调节诊断组之间的a β-认知关系。总之，这些发现表明，后缘HC冗余捕获了与Aβ沉积选择性易感性相似的网络破坏。此外，我们的研究结果表明，功能冗余可能强调不同于LFC的全局功能连接的网络度量。

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引用次数: 0

How gliomas affect white matter tract bundles associated with the limbic cortex 神经胶质瘤如何影响与边缘皮质相关的白质束

Q4 Neuroscience

Neuroimage. Reports

Pub Date : 2025-03-23 DOI: 10.1016/j.ynirp.2025.100256

Eric Fu, Anna D. Lee, Sera Sempson, John Thompson, D. Ryan Ormond

Introduction

While glioma incidence in the US has stabilized, prognosis remains poor. One underutilized MRI modality, Diffusion Tensor Imaging (DTI), could be used to better predict postoperative glioma resection outcomes. DTI measures the structural integrity of brain white matter tracts by measuring water diffusion. We examined whether lateralized gliomas affected the structure of limbic tract bundles, and whether those changes correlated with tumor location, size, and number of tracts within the bundle.

Methods

We conducted a retrospective study of 33 glioma patients who underwent preoperative DTI and examined the cingulum, fornix, and uncinate fasciculus. Using software (ITK-SNAP, DSI Studio), we obtained diffusion coefficients (fractional anisotropy (FA), mean diffusivity (MD)), tumor volume, lobe location, and tract number. With FA and MD as measures of axonal integrity, tracts of the non-tumor hemisphere(contralateral), the tumor hemisphere that is traversing the tumor (ipsilateral inclusive), and the tumor hemisphere without traversing the tumor (ipsilateral exclusive) were compared. Additionally, we correlated these hemispheric changes to tumor size, location, and FA/MD.

Results

In the cingulum, FA and MD are significantly different between contralateral and ipsilateral inclusive and between ipsilateral exclusive versus ipsilateral inclusive. Similar findings were found in the uncinate fasciculus MD. FA and MD of cingulum, fornix, and uncinate fasciculus are significantly correlated with the number of tracts within the tumor hemisphere.

Conclusion

Our study, one of the first to specifically examine limbic related tracts, shows that gliomas could increase white matter tracts numbers and impact structure. Localized impact on white matter integrity is in line with previous observations. These findings support DTI as a pre-op planning tool; white matter of significant limbic tracts are affected by gliomas and this change is measurable. We plan on further analyzing data to include how tumor location could affect white matter, and to incorporate patient post-op mortality and morbidity.

虽然胶质瘤在美国的发病率已经稳定，但预后仍然很差。一种未被充分利用的MRI模式，弥散张量成像（DTI），可以更好地预测胶质瘤术后切除结果。DTI通过测量水的扩散来测量脑白质束的结构完整性。我们研究了偏侧胶质瘤是否影响边缘束的结构，以及这些变化是否与肿瘤的位置、大小和束内束的数量相关。方法对33例术前行DTI的胶质瘤患者进行回顾性研究，并检查了扣带、穹窿和钩扣束。使用软件（ITK-SNAP, DSI Studio），我们获得扩散系数（分数各向异性（FA），平均扩散率（MD）），肿瘤体积，叶位置和束数。以FA和MD作为轴突完整性的测量指标，比较非肿瘤半球（对侧）、穿过肿瘤的肿瘤半球（同侧包括）和不穿过肿瘤的肿瘤半球（同侧不包括）的束。此外，我们将这些半球变化与肿瘤大小、位置和FA/MD联系起来。结果扣带FA和MD在对侧和同侧包容、同侧不包容和同侧包容之间存在显著差异。扣带、穹窿和钩状束的FA和MD与肿瘤半球内束的数量显著相关。结论我们的研究是第一个专门研究边缘相关束的研究之一，表明胶质瘤可以增加白质束的数量并影响结构。对白质完整性的局部影响与先前的观察一致。这些发现支持DTI作为术前规划工具；脑胶质瘤影响脑边缘束的白质，这种改变是可测量的。我们计划进一步分析数据，包括肿瘤位置如何影响白质，并纳入患者术后死亡率和发病率。

{"title":"How gliomas affect white matter tract bundles associated with the limbic cortex","authors":"Eric Fu, Anna D. Lee, Sera Sempson, John Thompson, D. Ryan Ormond","doi":"10.1016/j.ynirp.2025.100256","DOIUrl":"10.1016/j.ynirp.2025.100256","url":null,"abstract":"<div><h3>Introduction</h3><div>While glioma incidence in the US has stabilized, prognosis remains poor. One underutilized MRI modality, Diffusion Tensor Imaging (DTI), could be used to better predict postoperative glioma resection outcomes. DTI measures the structural integrity of brain white matter tracts by measuring water diffusion. We examined whether lateralized gliomas affected the structure of limbic tract bundles, and whether those changes correlated with tumor location, size, and number of tracts within the bundle.</div></div><div><h3>Methods</h3><div>We conducted a retrospective study of 33 glioma patients who underwent preoperative DTI and examined the cingulum, fornix, and uncinate fasciculus. Using software (ITK-SNAP, DSI Studio), we obtained diffusion coefficients (fractional anisotropy (FA), mean diffusivity (MD)), tumor volume, lobe location, and tract number. With FA and MD as measures of axonal integrity, tracts of the non-tumor hemisphere(contralateral), the tumor hemisphere that is traversing the tumor (ipsilateral inclusive), and the tumor hemisphere without traversing the tumor (ipsilateral exclusive) were compared. Additionally, we correlated these hemispheric changes to tumor size, location, and FA/MD.</div></div><div><h3>Results</h3><div>In the cingulum, FA and MD are significantly different between contralateral and ipsilateral inclusive and between ipsilateral exclusive versus ipsilateral inclusive. Similar findings were found in the uncinate fasciculus MD. FA and MD of cingulum, fornix, and uncinate fasciculus are significantly correlated with the number of tracts within the tumor hemisphere.</div></div><div><h3>Conclusion</h3><div>Our study, one of the first to specifically examine limbic related tracts, shows that gliomas could increase white matter tracts numbers and impact structure. Localized impact on white matter integrity is in line with previous observations. These findings support DTI as a pre-op planning tool; white matter of significant limbic tracts are affected by gliomas and this change is measurable. We plan on further analyzing data to include how tumor location could affect white matter, and to incorporate patient post-op mortality and morbidity.</div></div>","PeriodicalId":74277,"journal":{"name":"Neuroimage. Reports","volume":"5 2","pages":"Article 100256"},"PeriodicalIF":0.0,"publicationDate":"2025-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143681439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cognitive functioning and brain MRI findings six months after acute COVID-19. A prospective observational study 急性COVID-19后6个月的认知功能和脑MRI结果。一项前瞻性观察研究

Q4 Neuroscience

Neuroimage. Reports

Pub Date : 2025-03-22 DOI: 10.1016/j.ynirp.2025.100254

Janne Pihlajamaa , Henriikka Ollila , Juha Martola , Linda Kuusela , Riikka Pihlaja , Annamari Tuulio-Henriksson , Sanna Koskinen , Viljami Salmela , Laura Hokkanen , Marjaana Tiainen , Johanna Hästbacka

Introduction

COVID-19 has been linked to many neurological complications, including cognitive impairment and findings in brain imaging. However, limited data exist regarding the link between magnetic resonance imaging (MRI) findings and cognitive functioning in COVID-19 patients.

In this observational prospective study, we investigated the association between brain MRI findings, particularly cerebral microbleeds (CMBs) and white matter hyperintensities (WMHs), and cognitive functioning in COVID-19 survivors.

Methods

Six months after acute COVID-19 diagnosed in 2020, 67 ICU-treated, 44 ward-treated, and 44 home-isolated patients, as well as 48 non-COVID-19 controls, underwent MRI and comprehensive neuropsychological evaluation. We applied multivariable linear regression models to investigate the independent associations of total cognitive score and domain scores separately with CMBs, WMHs and other factors.

Results

Age (p < 0.001, β = −0.36) and educational level (p < 0.001, β = 0.42) predominantly explained the differences in cognitive functioning. A lower total cognitive score was associated with the number of CMBs (p = 0.0016), but not with COVID-19 (p = 0.714). Among COVID-19 patients, treatment in a regular ward (p = 0.007, β = −0.46), a high burden of WMHs (p = 0.004, β = −1.35), and having one to three CMBs (p = 0.01, β = −0.43) were associated with lower total cognitive scores.

Conclusion

We observed a significant association between the presence of CMBs and lower cognitive scores, regardless of COVID-19 history. However, our results do not support CMBs to be independently associated with cognitive functioning. Additionally, WMH burden was associated with lower cognitive scores.

covid -19与许多神经系统并发症有关，包括认知障碍和脑成像结果。然而，关于COVID-19患者的磁共振成像（MRI）结果与认知功能之间的联系的数据有限。在这项观察性前瞻性研究中，我们调查了脑MRI结果，特别是脑微出血（CMBs）和白质高强度（WMHs）与COVID-19幸存者认知功能之间的关系。方法对2020年确诊急性COVID-19的67例重症监护室患者、44例病房患者、44例家庭隔离患者及48例非COVID-19对照组进行MRI和综合神经心理评估。我们应用多变量线性回归模型分别考察了认知总分和领域得分与CMBs、wmh等因素的独立相关性。结果：年龄(p <；0.001, β = - 0.36)和教育水平(p <；0.001, β = 0.42)主要解释了认知功能的差异。认知总分较低与CMBs数量相关（p = 0.0016），但与COVID-19无关（p = 0.714）。在COVID-19患者中，在常规病房接受治疗（p = 0.007, β = - 0.46）、高wmh负担（p = 0.004, β = - 1.35）和有1至3个CMBs （p = 0.01, β = - 0.43）与总认知评分较低相关。结论我们观察到CMBs的存在与较低的认知评分之间存在显著关联，无论是否有COVID-19病史。然而，我们的研究结果并不支持CMBs与认知功能独立相关。此外，WMH负担与较低的认知得分有关。

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引用次数: 0

Fixel based analysis on diffusion MRI of COVID-19 survivors 基于Fixel的COVID-19幸存者弥散MRI分析

Q4 Neuroscience

Neuroimage. Reports

Pub Date : 2025-03-22 DOI: 10.1016/j.ynirp.2025.100253

Sapna S Mishra , Tapan Kumar Gandhi , Bharat Biswal

The underlying mechanisms of long-term sequelae of the COVID-19 infection, including fatigue, memory issues, and attention deficit, remain to be understood. Therefore, we investigated the Diffusion MRI scans of 73 COVID-Recovered Patients (CRPs) and 46 Healthy Controls (HCs) using Fixel-based analysis to study the sub-voxel microstructural properties of nervous tissue. We compared the Fiber Density (FD), log scaled Fiber Cross-section (log-FC), and a combined fiber density and cross-section measure (FDC) across the cohorts. Our study reveals significant alterations (pFWE <0.01) in the uncinate fasciculus (FD, log-FC, FDC; CRP > HC), perigenual corpus callosum (FD; CRP > HC), fornix (log-FC, FDC; CRP > HC), right arcuate fasciculus (FD; CRP < HC), as well as bilateral clusters in the inferior longitudinal fasciculus (FD; CRP < HC), and the corticospinal tract (FD; CRP < HC). We suggest that these changes may be related to microscopic changes in axonal volume. Notably, the tracts identified in this study highlight the involvement of the limbic system and the visuospatial attention network in the disorder. We expect our findings to improve our understanding of the neurological underpinnings of COVID-19.

COVID-19感染长期后遗症的潜在机制，包括疲劳、记忆问题和注意力缺陷，仍有待了解。因此，我们使用基于fixel的分析方法研究了73例covid - 19康复患者（CRPs）和46例健康对照（hc）的弥散MRI扫描，以研究神经组织的亚体素微结构特性。我们比较了整个队列的纤维密度（FD）、对数缩放纤维截面（log- fc）和纤维密度和截面测量（FDC）的组合。我们的研究显示钩侧束(FD, log-FC， FDC；c反应蛋白在HC)，胼胝体(FD；c反应蛋白在HC)，穹窿(log-FC， FDC；c反应蛋白在HC)，右弓状束(FD；CRP & lt;HC)，以及双侧下纵束簇(FD；CRP & lt;HC)和皮质脊髓束(FD；CRP & lt;HC)。我们认为这些变化可能与轴突体积的微观变化有关。值得注意的是，本研究中发现的神经束强调了边缘系统和视觉空间注意网络在该疾病中的参与。我们希望我们的发现能够提高我们对COVID-19神经学基础的理解。

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引用次数: 0

Repeatability and reproducibility of brain age estimates in multiple sclerosis for three publicly available models 三种公开可用模型对多发性硬化症脑年龄估计的可重复性和再现性

Q4 Neuroscience

Neuroimage. Reports

Pub Date : 2025-03-21 DOI: 10.1016/j.ynirp.2025.100252

Lonneke Bos , David R. van Nederpelt , J.H. Cole , E.M.M. Strijbis , B. Moraal , J.P.A. Kuijer , B.M.J. Uitdehaag , F. Barkhof , A.M. Wink , H. Vrenken , B. Jasperse

Accelerated brain aging is a marker of disease-related neurodegeneration in multiple sclerosis (MS). Artificial intelligence models, trained on healthy individuals, can estimate age from brain MRI scans, but the effects of technical variations between MR scanners and conditions on these estimates are currently insufficiently investigated. This study aims to determine the within-scanner repeatability and between-scanner reproducibility of the brain-predicted age difference (brain-PAD) across three brain age models.

30 people with multiple sclerosis and 10 healthy controls (mean age 44.2 ± 11.7 years and 39.2 ± 12.9 years, respectively), underwent six scans in a single day; a scan and immediate on a 3 T GE, 1.5 T Siemens and a 3 T Siemens MRI-scanner. Brain-PAD was determined using brainageR, DeepBrainNet and the MIDI-model from 3D T1w brain MRI-scans. Intraclass correlation coefficient (ICC) was used to quantify absolute agreement within-scanner (ICC-AA) and between-scanner consistency (ICC-C). Variance component analyses were used to determine the standard error of measurement (SEM) and the smallest detectable change (SDC).

Brain-PAD was higher for pwMS compared to HC when predicted with brainageR and DeepBrainNet, not when predicted with the MIDI-model. Within-scanner repeatability was excellent (ICC-AA>0.93) for all models. Between-scanner reproducibility was good to excellent (ICC-C>0.85) for brainageR and the MIDI-model, while DeepBrainNet, showed excellent between-scanner reproducibility for Sola vs. VIDA (ICC-C:0.97), but moderate for GE vs. Sola and for GE vs. Vida (ICC-C:0.63 and 0.61). Between-scanner SDC was 6.56 years for brainageR, 5.57 years for the MIDI-model and 22.65 years for DeepBrainNet.

Our findings demonstrated high repeatability of brain age estimates from the same scanner, but variable reproducibility across different scanners, irrespective of the brain age prediction model.

加速脑老化是多发性硬化症（MS）疾病相关神经变性的标志。对健康个体进行训练的人工智能模型可以从脑MRI扫描中估计年龄，但磁共振扫描仪和条件之间的技术差异对这些估计的影响目前尚未得到充分研究。本研究旨在确定三种脑年龄模型中脑预测年龄差异（brain- pad）的扫描内可重复性和扫描间可重复性。30名多发性硬化症患者和10名健康对照者（平均年龄分别为44.2±11.7岁和39.2±12.9岁）在一天内进行了6次扫描；立即在3t GE， 1.5 T Siemens和3t Siemens mri扫描仪上进行扫描。使用brainageR， DeepBrainNet和3D T1w脑mri扫描的midi模型确定脑- pad。用类内相关系数（ICC）量化扫描仪内绝对一致性（ICC- aa）和扫描仪间一致性（ICC- c）。方差成分分析用于确定测量的标准误差（SEM）和最小可检测变化（SDC）。用brainageR和DeepBrainNet预测时，pwMS的Brain-PAD比HC高，而用midi模型预测时则没有。所有型号的扫描仪内重复性都很好（ICC-AA>0.93）。brainageR和midi -模型的扫描仪间再现性为良好至优异（ICC-C>0.85），而DeepBrainNet对Sola与VIDA的扫描仪间再现性为优异（ICC-C:0.97），但对GE与Sola和GE与VIDA的扫描仪间再现性为中等（ICC-C:0.63和0.61）。brainageR的扫描间隔SDC为6.56年，MIDI-model为5.57年，DeepBrainNet为22.65年。我们的研究结果表明，从同一台扫描仪估计的脑年龄具有很高的可重复性，但与脑年龄预测模型无关，不同扫描仪的可重复性存在差异。

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引用次数: 0

Domain-specific brain regions are associated with cognitive impairment in progressive supranuclear palsy 脑区域特异性与进行性核上性麻痹的认知障碍有关

Q4 Neuroscience

Neuroimage. Reports

Pub Date : 2025-03-01 DOI: 10.1016/j.ynirp.2025.100247

N. Schröter , M. Rijntjes , J.A. Hosp , M. Reisert , H. Mast , C. Weiller , P. Oikonomou , L. Frings , H. Urbach , W.H. Jost , A. Rau

Background

Cognitive impairment significantly contributes to the disease burden of progressive supranuclear palsy (PSP), however, the underlying pathophysiologiy is not well understood.

Objectives

To gain a better understanding of the pathophysiology, we identified the brain regions associated with individual domains of impaired cognition.

Methods

We analyzed MRI data from a cohort of 31 patients with PSP (age 71.0 +-7.0 years, range 58–87; 15 females; disease duration 2.9 +- 1.8 years). Cerebral microstructure was approximated with Diffusion Microstructure Imaging and cognitive performance was measured using the Frontal Assessment Battery (FAB) and Montreal Cognitive Assessment (MoCA). To reveal the underlying affected brain regions, whole-brain voxel-wise associations were employed to test the microstructural metrics regarding their correlation with the FAB as well as the individual cognitive domains ‚Attention‘, ‚Execution‘, ‚Language‘, ‚Memory‘, ‚Orientation‘, and ‚Visuoconstruction‘ derived from MoCA.

Results

MoCA performance was impaired in 87.5% of patients (20.2 +- 5.4 points, range 8–28; cut-off value: <26/30). In the voxel-wise analyses, we noted significant associations of cerebral microstructure and FAB in the right-sided frontal and temporopolar white matter, deficits in ‚Memory‘ with hippocampal and temporomesial regions, in reduced ‚Orientation‘ with wide spread white-matter areas with a parietal accentuation, whereas deficits in ‚Attention‘ correlated with frontal and prefrontal structures.

Conclusions

Diffusion Microstructure Imaging revealed domain-specific regions of neurodegenerative alterations in PSP. The regions identified in this approach integrate well in existing disease concepts. They might therefore be a possible biomarker for cognitive impairment, as well as amonitoring parameter for future disease modifying therapeutics.

认知障碍是进行性核上性麻痹（PSP）的疾病负担的重要因素，然而，其潜在的病理生理机制尚不清楚。目的为了更好地理解病理生理学，我们确定了与个体认知障碍相关的大脑区域。方法分析31例PSP患者的MRI数据(年龄71.0 +-7.0岁，范围58-87；15个女性;病程2.9 +- 1.8年)。采用扩散微结构成像（Diffusion microstructimaging，简称弥散微结构成像）模拟大脑微结构，采用前额叶评估电池（FAB）和蒙特利尔认知评估（MoCA）测试认知能力。为了揭示潜在的受影响的大脑区域，采用全脑体素关联来测试微观结构指标与FAB以及来自MoCA的个体认知领域（注意力、执行、语言、记忆、方向和视觉构建）的相关性。结果87.5%的患者smoca功能受损(20.2 + ~ 5.4分，范围8 ~ 28分；截止值：26/30)。在体素分析中，我们注意到大脑微观结构和FAB在右侧额叶和颞叶白质中的显著关联，“记忆”缺陷与海马和颞叶区域有关，“定向”缺陷与广泛的白质区域有关，顶叶突出，而“注意力”缺陷与额叶和前额叶结构有关。结论弥散显微成像显示了PSP神经退行性改变的特定区域。这种方法确定的区域与现有的疾病概念很好地结合在一起。因此，它们可能是认知障碍的可能生物标志物，以及未来疾病修饰治疗的监测参数。

{"title":"Domain-specific brain regions are associated with cognitive impairment in progressive supranuclear palsy","authors":"N. Schröter , M. Rijntjes , J.A. Hosp , M. Reisert , H. Mast , C. Weiller , P. Oikonomou , L. Frings , H. Urbach , W.H. Jost , A. Rau","doi":"10.1016/j.ynirp.2025.100247","DOIUrl":"10.1016/j.ynirp.2025.100247","url":null,"abstract":"<div><h3>Background</h3><div>Cognitive impairment significantly contributes to the disease burden of progressive supranuclear palsy (PSP), however, the underlying pathophysiologiy is not well understood.</div></div><div><h3>Objectives</h3><div>To gain a better understanding of the pathophysiology, we identified the brain regions associated with individual domains of impaired cognition.</div></div><div><h3>Methods</h3><div>We analyzed MRI data from a cohort of 31 patients with PSP (age 71.0 +-7.0 years, range 58–87; 15 females; disease duration 2.9 +- 1.8 years). Cerebral microstructure was approximated with Diffusion Microstructure Imaging and cognitive performance was measured using the Frontal Assessment Battery (FAB) and Montreal Cognitive Assessment (MoCA). To reveal the underlying affected brain regions, whole-brain voxel-wise associations were employed to test the microstructural metrics regarding their correlation with the FAB as well as the individual cognitive domains ‚Attention‘, ‚Execution‘, ‚Language‘, ‚Memory‘, ‚Orientation‘, and ‚Visuoconstruction‘ derived from MoCA.</div></div><div><h3>Results</h3><div>MoCA performance was impaired in 87.5% of patients (20.2 +- 5.4 points, range 8–28; cut-off value: <26/30). In the voxel-wise analyses, we noted significant associations of cerebral microstructure and FAB in the right-sided frontal and temporopolar white matter, deficits in ‚Memory‘ with hippocampal and temporomesial regions, in reduced ‚Orientation‘ with wide spread white-matter areas with a parietal accentuation, whereas deficits in ‚Attention‘ correlated with frontal and prefrontal structures.</div></div><div><h3>Conclusions</h3><div>Diffusion Microstructure Imaging revealed domain-specific regions of neurodegenerative alterations in PSP. The regions identified in this approach integrate well in existing disease concepts. They might therefore be a possible biomarker for cognitive impairment, as well as amonitoring parameter for future disease modifying therapeutics.</div></div>","PeriodicalId":74277,"journal":{"name":"Neuroimage. Reports","volume":"5 1","pages":"Article 100247"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143534973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Functional connectivity of subsystems of the default-mode network in patients with early psychotic symptoms 早期精神病症状患者默认模式网络子系统的功能连通性

Q4 Neuroscience

Neuroimage. Reports

Pub Date : 2025-03-01 DOI: 10.1016/j.ynirp.2025.100248

Nicky Lute , Imke Lemmers-Jansen , Lydia Krabbendam , Mariët van Buuren

Resting-state connectivity of the default-mode network (DMN) is aberrant in patients with chronic psychotic disorders as well in individuals with early stage psychosis. Studies of the DMN in healthy volunteers revealed that the DMN comprises several subnetworks. However, it is not yet clear if connectivity between and within these DMN subnetworks is aberrant in patients with early psychotic symptoms nor whether these connectivity patterns are related to symptomatology. This initial investigation examined functional connectivity between and within the DMN subnetworks in patients with early psychotic symptoms and in healthy volunteers, and probed how these connectivity patterns were related to the severity of clinical symptomatology. Functional connectivity was measured during resting-state in 30 patients with early psychotic symptoms and in 39 controls using functional MRI. We did not observe differences in connectivity within and between the subnetworks of the DMN between the control group and the early psychosis group. However, lower functional connectivity between the medial prefrontal and posterior medial subnetworks and between medial prefrontal and anterior temporal subnetworks of the DMN did predict the severity of the negative symptoms. The findings of this initial investigation provide insight into the associations between functional connectivity of DMN subnetworks and symptomatology in patients with early psychotic symptoms.

在慢性精神病患者和早期精神病患者中，默认模式网络（DMN）的静息状态连通性是异常的。对健康志愿者DMN的研究表明，DMN由几个子网络组成。然而，目前尚不清楚这些DMN子网络之间和内部的连接是否在早期精神病症状患者中异常，也不清楚这些连接模式是否与症状学有关。这项初步研究检查了早期精神病症状患者和健康志愿者DMN子网络之间和内部的功能连接，并探讨了这些连接模式如何与临床症状的严重程度相关。在30例早期精神病症状患者和39例对照患者的静息状态下，使用功能MRI测量功能连通性。我们没有观察到对照组和早期精神病组之间DMN子网内部和子网之间的连通性差异。然而，DMN内侧前额叶和后部内侧亚网络之间以及内侧前额叶和颞叶前部亚网络之间较低的功能连通性确实预测了阴性症状的严重程度。这项初步研究的结果为早期精神病症状患者的DMN子网络功能连通性与症状之间的关系提供了见解。

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引用次数: 0