Pub Date : 2025-03-01Epub Date: 2025-05-01DOI: 10.1177/15579883251329715
Timothy Price
This qualitative study explores the factors contributing to gender-based inequalities in "deaths of despair" (DoD) - those deaths from suicide, drug overdoses, and alcohol-specific causes - among men in two deindustrialised towns in North East England. Understanding gender-based disparities in these causes of death sheds important light on how social and economic factors intersect with certain facets of masculinity, such as stoicism and self-reliance, to drive vulnerability. Data were collected through semi-structured interviews and one focus group with 54 stakeholders - people whose work is related to DoD, such as mental health treatment and public health practice - and community members in Middlesbrough and South Tyneside, two towns with above average rates of DoD. Participants included both men and women, predominantly of middle-age or older, with most participants unemployed or retired. Data were analysed using Iterative Categorisation, with findings interpreted through thematic analysis. The study generated three key themes: industrial history and masculinity, masculinity and class, and masculinity as a barrier to help-seeking. The findings demonstrate that economic decline following deindustrialisation resulted in distress and created unique risk factors for substance use and self-harm for men. These results suggest that effective interventions to reduce DoD among men in post-industrial settings must avoid pathologising masculinity itself. Instead, strategies should focus on the broader structural forces that undermine men's access to stable, fulfilling employment and offering forms of support that are compatible with masculine identity. By addressing these determinants, interventions can more effectively close gender-based inequalities and reduce the rate of DoD in deindustrialised areas.
{"title":"\"They're Lacking Purpose. It's a Recipe for Suicide.\": Masculinity and Gender-Based Inequalities in Deaths of Despair in England.","authors":"Timothy Price","doi":"10.1177/15579883251329715","DOIUrl":"https://doi.org/10.1177/15579883251329715","url":null,"abstract":"<p><p>This qualitative study explores the factors contributing to gender-based inequalities in \"deaths of despair\" (DoD) - those deaths from suicide, drug overdoses, and alcohol-specific causes - among men in two deindustrialised towns in North East England. Understanding gender-based disparities in these causes of death sheds important light on how social and economic factors intersect with certain facets of masculinity, such as stoicism and self-reliance, to drive vulnerability. Data were collected through semi-structured interviews and one focus group with 54 stakeholders - people whose work is related to DoD, such as mental health treatment and public health practice - and community members in Middlesbrough and South Tyneside, two towns with above average rates of DoD. Participants included both men and women, predominantly of middle-age or older, with most participants unemployed or retired. Data were analysed using Iterative Categorisation, with findings interpreted through thematic analysis. The study generated three key themes: industrial history and masculinity, masculinity and class, and masculinity as a barrier to help-seeking. The findings demonstrate that economic decline following deindustrialisation resulted in distress and created unique risk factors for substance use and self-harm for men. These results suggest that effective interventions to reduce DoD among men in post-industrial settings must avoid pathologising masculinity itself. Instead, strategies should focus on the broader structural forces that undermine men's access to stable, fulfilling employment and offering forms of support that are compatible with masculine identity. By addressing these determinants, interventions can more effectively close gender-based inequalities and reduce the rate of DoD in deindustrialised areas.</p>","PeriodicalId":7429,"journal":{"name":"American Journal of Men's Health","volume":"19 2","pages":"15579883251329715"},"PeriodicalIF":2.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12049619/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143959743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-03-01Epub Date: 2025-03-27DOI: 10.1177/15579883251323251
Åsa Leanderz, Maria Henricson, Frida Lygnegård, Caroline Bäckström, Margaretha Larsson
For fathers, the transition to parenthood can be experienced as an emotional phase. Fathers often state feeling overlooked and unsupported during their transition to parenthood. This study addressed this issue by exploring what it means to become a father-a qualitative design with a phenomenological hermeneutical approach. Data were collected through open-ended interviews with 19 fathers living in Sweden. The participants were encouraged to reflect on the meaning of becoming a father. Becoming a father means feeling connectedness to their child, their partner, and their friends, as well as creating strategies entailing flexibility, engagement, management, support, and solitude in their new situation. Fathers use digital media for support to create strategies, but it can evoke anxiety. The meaning of becoming a father concludes that they are deeply affected by the new situation. To support fathers during their transition to parenthood, midwives and child healthcare nurses should facilitate reflective conversations with them about their experiences of becoming a father. This study was guided by the Consolidated Criteria for Reporting Qualitative Research Checklist.
{"title":"What It Means to Become a Father.","authors":"Åsa Leanderz, Maria Henricson, Frida Lygnegård, Caroline Bäckström, Margaretha Larsson","doi":"10.1177/15579883251323251","DOIUrl":"10.1177/15579883251323251","url":null,"abstract":"<p><p>For fathers, the transition to parenthood can be experienced as an emotional phase. Fathers often state feeling overlooked and unsupported during their transition to parenthood. This study addressed this issue by exploring what it means to become a father-a qualitative design with a phenomenological hermeneutical approach. Data were collected through open-ended interviews with 19 fathers living in Sweden. The participants were encouraged to reflect on the meaning of becoming a father. Becoming a father means feeling connectedness to their child, their partner, and their friends, as well as creating strategies entailing flexibility, engagement, management, support, and solitude in their new situation. Fathers use digital media for support to create strategies, but it can evoke anxiety. The meaning of becoming a father concludes that they are deeply affected by the new situation. To support fathers during their transition to parenthood, midwives and child healthcare nurses should facilitate reflective conversations with them about their experiences of becoming a father. This study was guided by the Consolidated Criteria for Reporting Qualitative Research Checklist.</p>","PeriodicalId":7429,"journal":{"name":"American Journal of Men's Health","volume":"19 2","pages":"15579883251323251"},"PeriodicalIF":2.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11952029/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143717782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-03-01Epub Date: 2025-03-31DOI: 10.1177/15579883251330117
Sonya S Brady, Andrés Arguedas, Jared D Huling, Gerhard Hellemann, Cora E Lewis, David R Jacobs, Cynthia S Fok, Stephen K Van Den Eeden, Alayne D Markland
This research utilizes Coronary Artery Risk Development in Young Adults (CARDIA) cohort study data to examine whether financial strain is associated with subsequent lower urinary tract symptoms among men and whether healthcare barriers, health risk behaviors, and comorbid conditions explain this association. CARDIA recruited Black and White participants aged 18 to 30 years at baseline (1985-1986) from four United States cities. The analytic sample was comprised of men with complete data for analyses involving financial strain trajectories across 7 assessments (n = 602) and mediation tests of data collected at 4 assessments (n = 634). The outcome variable, assessed when the mean age of men was 50 years, was the American Urologic Association Symptom Index score, recoded into four symptom categories: none (6.3%); mild (62.6%), moderate (28.5%), and severe (2.6%). Symptom category was regressed on financial strain variables, adjusting for age, race, education, and self-reported benign prostatic hyperplasia. Regression analyses and structural equation modeling tested potential mediators. Compared to not being financially strained across early and midlife adulthood, experiencing more than one shift in financial strain was associated with 84% greater odds (95% confidence interval [1.24, 2.75]) of being categorized into a worse symptom category. Structural equation modeling showed that both difficulty receiving healthcare and depressive symptoms explained an association between difficulty paying for medical care and worse symptoms. Additional research is needed to confirm findings and examine other mechanisms that may further explain associations between financial strain and symptoms, such as stress responses. Accumulated evidence may inform future prevention interventions, including integrated healthcare approaches.
{"title":"Financial Strain Across 25 years and Men's Lower Urinary Tract Symptoms: A Life Course Perspective.","authors":"Sonya S Brady, Andrés Arguedas, Jared D Huling, Gerhard Hellemann, Cora E Lewis, David R Jacobs, Cynthia S Fok, Stephen K Van Den Eeden, Alayne D Markland","doi":"10.1177/15579883251330117","DOIUrl":"10.1177/15579883251330117","url":null,"abstract":"<p><p>This research utilizes Coronary Artery Risk Development in Young Adults (CARDIA) cohort study data to examine whether financial strain is associated with subsequent lower urinary tract symptoms among men and whether healthcare barriers, health risk behaviors, and comorbid conditions explain this association. CARDIA recruited Black and White participants aged 18 to 30 years at baseline (1985-1986) from four United States cities. The analytic sample was comprised of men with complete data for analyses involving financial strain trajectories across 7 assessments (<i>n</i> = 602) and mediation tests of data collected at 4 assessments (<i>n</i> = 634). The outcome variable, assessed when the mean age of men was 50 years, was the American Urologic Association Symptom Index score, recoded into four symptom categories: none (6.3%); mild (62.6%), moderate (28.5%), and severe (2.6%). Symptom category was regressed on financial strain variables, adjusting for age, race, education, and self-reported benign prostatic hyperplasia. Regression analyses and structural equation modeling tested potential mediators. Compared to not being financially strained across early and midlife adulthood, experiencing more than one shift in financial strain was associated with 84% greater odds (95% confidence interval [1.24, 2.75]) of being categorized into a worse symptom category. Structural equation modeling showed that both difficulty receiving healthcare and depressive symptoms explained an association between difficulty paying for medical care and worse symptoms. Additional research is needed to confirm findings and examine other mechanisms that may further explain associations between financial strain and symptoms, such as stress responses. Accumulated evidence may inform future prevention interventions, including integrated healthcare approaches.</p>","PeriodicalId":7429,"journal":{"name":"American Journal of Men's Health","volume":"19 2","pages":"15579883251330117"},"PeriodicalIF":2.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11960169/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143750631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-03-01Epub Date: 2025-03-27DOI: 10.1177/15579883251327907
Xiao Liu, Lei Huo, Feng Wang, Tian Wang, Wenchao Rong, Yu He
The 1,000-m run is a key component of university physical fitness assessments. Effective supplementation strategies to enhance performance and recovery in this test remain underexplored. This study aimed to evaluate the effects of caffeine (CAF) and beetroot juice (BJ) on 1,000-m performance and used SHapley Additive exPlanations (SHAP) analysis to identify key influencing factors. A randomized crossover design compared the effects of CAF (6 mg/kg body weight), BJ (70 mL providing 6.4 mmol of ), and their combination with placebo (PLA) on 1,000-m running performance. Twenty healthy male participants took part in the study. Physiological, nutritional, and behavioral data were collected during each condition. SHAP analysis of a multilayer perceptron model quantified the relative importance of various performance determinants, providing a clear assessment of their contribution to the outcome. The CAF + BJ group performed significantly better than PLA (p < .01) in the first 1,000-m run and outperformed both PLA and BJ in the second run (p < .01). Performance declined after recovery in BJ (p < .01) and PLA (p < .01) but improved in CAF + BJ (p < .01). Post-exercise heart rate and blood lactate were highest in CAF + BJ and CAF, with CAF showing significantly higher lactate levels at 10, 15, and 20 min post-exercise compared to CAF + BJ (p < .01). SHAP analysis ranked body fat percentage > weight > age > nighttime sleep duration > nutritional strategy > average vertical jump height > grip strength > resting heart rate > time since last meal > alcohol consumption > height > smoking frequency. This study suggests that CAF and BJ supplementation may improve 1,000-m performance. SHAP analysis introduced a novel framework for identifying key factors, offering insights for targeted interventions. Tailored dietary supplement strategies that address critical physiological and lifestyle factors are important. Combining supplementation with these approaches can further enhance performance and recovery.
1000米跑是大学身体健康评估的重要组成部分。在该测试中,提高性能和恢复的有效补充策略仍未得到充分研究。本研究旨在评价咖啡因(CAF)和甜菜根汁(BJ)对1000 -m性能的影响,并利用SHapley加性解释(SHAP)分析找出关键影响因素。采用随机交叉设计比较CAF (6 mg/kg体重)、BJ (70 mL提供6.4 mmol NO3-)及其与安慰剂(PLA)联合使用对1000米跑步性能的影响。20名健康男性参与者参加了这项研究。在每种情况下收集生理、营养和行为数据。多层感知器模型的SHAP分析量化了各种性能决定因素的相对重要性,提供了对其对结果的贡献的明确评估。CAF + BJ组的表现明显优于PLA组(p p p p p p p)体重(p p p p p)年龄(p p p p p p体重(p p p p p体重)年龄(p p p p体重)夜间睡眠时间(p p p体重)营养策略(p p p体重)平均垂直跳高(p p p体重)握力(p p p营养策略)静息心率(p p p体重)从最后一餐开始的时间(p p p p体重)本研究表明,补充CAF和BJ可提高1000米运动性能。SHAP分析引入了一种识别关键因素的新框架,为有针对性的干预措施提供了见解。针对关键生理和生活方式因素的量身定制的膳食补充策略很重要。将补充剂与这些方法结合使用可以进一步提高性能和恢复能力。
{"title":"Caffeine and Beetroot Juice Optimize 1,000-m Performance: Shapley Additive Explanations Analysis.","authors":"Xiao Liu, Lei Huo, Feng Wang, Tian Wang, Wenchao Rong, Yu He","doi":"10.1177/15579883251327907","DOIUrl":"10.1177/15579883251327907","url":null,"abstract":"<p><p>The 1,000-m run is a key component of university physical fitness assessments. Effective supplementation strategies to enhance performance and recovery in this test remain underexplored. This study aimed to evaluate the effects of caffeine (CAF) and beetroot juice (BJ) on 1,000-m performance and used SHapley Additive exPlanations (SHAP) analysis to identify key influencing factors. A randomized crossover design compared the effects of CAF (6 mg/kg body weight), BJ (70 mL providing 6.4 mmol of <math><mrow><msubsup><mrow><mi>NO</mi></mrow><mrow><mn>3</mn></mrow><mrow><mo>-</mo></mrow></msubsup></mrow></math>), and their combination with placebo (PLA) on 1,000-m running performance. Twenty healthy male participants took part in the study. Physiological, nutritional, and behavioral data were collected during each condition. SHAP analysis of a multilayer perceptron model quantified the relative importance of various performance determinants, providing a clear assessment of their contribution to the outcome. The CAF + BJ group performed significantly better than PLA (<i>p</i> < .01) in the first 1,000-m run and outperformed both PLA and BJ in the second run (<i>p</i> < .01). Performance declined after recovery in BJ (<i>p</i> < .01) and PLA (<i>p</i> < .01) but improved in CAF + BJ (<i>p</i> < .01). Post-exercise heart rate and blood lactate were highest in CAF + BJ and CAF, with CAF showing significantly higher lactate levels at 10, 15, and 20 min post-exercise compared to CAF + BJ (<i>p</i> < .01). SHAP analysis ranked body fat percentage > weight > age > nighttime sleep duration > nutritional strategy > average vertical jump height > grip strength > resting heart rate > time since last meal > alcohol consumption > height > smoking frequency. This study suggests that CAF and BJ supplementation may improve 1,000-m performance. SHAP analysis introduced a novel framework for identifying key factors, offering insights for targeted interventions. Tailored dietary supplement strategies that address critical physiological and lifestyle factors are important. Combining supplementation with these approaches can further enhance performance and recovery.</p>","PeriodicalId":7429,"journal":{"name":"American Journal of Men's Health","volume":"19 2","pages":"15579883251327907"},"PeriodicalIF":2.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11948570/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143717780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-03-01Epub Date: 2025-03-28DOI: 10.1177/15579883251329679
Corina Mills, Hossein Zare, Genie Han, Courtney Thomas Tobin, Roland J Thorpe
Prior disparities in obesity research emphasize socioeconomic status as a potential driver of White-Black differences in obesity prevalence, but there is a paucity of research examining the influence of education on the observed racial difference among men. The objective of this study was to determine whether the relationship between race and obesity varies by education level among Non-Hispanic White (NHW) and Non-Hispanic Black (NHB) men. We used 1999 to 2016 National Health and Nutrition Examination Survey data consisting of a sample of 13,583 men (9,459 NHW and 4,124 NHB). Race and Ethnicity were determined by self-reports of whether they were Hispanic or not and their racial group. Education was based on self-reporting of the highest grade level or level of school completed and categorized as: less than high school, high school diploma or General Equivalency Diploma, some college or associate degree, and college degree or above. Thirty-four percent of the men were obese (body mass index [BMI] > 30 kg/m2); a higher proportion of NHB men reported being obese than NHW men (36.0%, n = 1,508, vs. 33.8%, n = 3,140; p = .049). Adjusting for age, marital status, income, insurance status, smoking status, drinking status, self-rated health, physical inactivity, and the number of chronic conditions, NHB men with a college degree or above had a higher prevalence of obesity (prevalence ratio: 1.21, confidence interval [1.06, 1.39]) than NHW men. Findings suggest that among college-educated NHW and NHB men, there is a relationship between race/ethnicity and obesity prevalence.
先前肥胖研究的差异强调社会经济地位是白人和黑人肥胖患病率差异的潜在驱动因素,但研究教育对观察到的男性种族差异的影响的研究很少。本研究的目的是确定种族和肥胖之间的关系是否因非西班牙裔白人(NHW)和非西班牙裔黑人(NHB)男性的教育水平而异。我们使用1999年至2016年国家健康与营养检查调查数据,包括13583名男性(9459名NHW和4124名NHB)的样本。种族和民族是由他们是否西班牙裔和他们的种族群体的自我报告决定的。教育基于自我报告的最高年级水平或完成的学校水平,并分类为:高中以下,高中文凭或普通等同文凭,一些大学或副学士学位,大学学位或以上。34%的男性肥胖(身体质量指数[BMI]达到30 kg/m2);NHB男性报告肥胖的比例高于NHW男性(36.0%,n = 1,508, 33.8%, n = 3,140;p = .049)。调整年龄、婚姻状况、收入、保险状况、吸烟状况、饮酒状况、自评健康状况、缺乏运动、慢性病数量等因素后,大专及以上学历NHB男性的肥胖患病率高于NHW男性(患病率比:1.21,置信区间[1.06,1.39])。研究结果表明,在受过大学教育的NHW和NHB男性中,种族/民族与肥胖患病率之间存在关系。
{"title":"The Relationship Between Race and Obesity Among Non-Hispanic White and Non-Hispanic Black Men by Education Level.","authors":"Corina Mills, Hossein Zare, Genie Han, Courtney Thomas Tobin, Roland J Thorpe","doi":"10.1177/15579883251329679","DOIUrl":"10.1177/15579883251329679","url":null,"abstract":"<p><p>Prior disparities in obesity research emphasize socioeconomic status as a potential driver of White-Black differences in obesity prevalence, but there is a paucity of research examining the influence of education on the observed racial difference among men. The objective of this study was to determine whether the relationship between race and obesity varies by education level among Non-Hispanic White (NHW) and Non-Hispanic Black (NHB) men. We used 1999 to 2016 National Health and Nutrition Examination Survey data consisting of a sample of 13,583 men (9,459 NHW and 4,124 NHB). Race and Ethnicity were determined by self-reports of whether they were Hispanic or not and their racial group. Education was based on self-reporting of the highest grade level or level of school completed and categorized as: less than high school, high school diploma or General Equivalency Diploma, some college or associate degree, and college degree or above. Thirty-four percent of the men were obese (body mass index [BMI] > 30 kg/m<sup>2</sup>); a higher proportion of NHB men reported being obese than NHW men (36.0%, <i>n</i> = 1,508, vs. 33.8%, <i>n</i> = 3,140; <i>p</i> = .049). Adjusting for age, marital status, income, insurance status, smoking status, drinking status, self-rated health, physical inactivity, and the number of chronic conditions, NHB men with a college degree or above had a higher prevalence of obesity (prevalence ratio: 1.21, confidence interval [1.06, 1.39]) than NHW men. Findings suggest that among college-educated NHW and NHB men, there is a relationship between race/ethnicity and obesity prevalence.</p>","PeriodicalId":7429,"journal":{"name":"American Journal of Men's Health","volume":"19 2","pages":"15579883251329679"},"PeriodicalIF":2.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11954513/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143727373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-03-01Epub Date: 2025-04-28DOI: 10.1177/15579883251334561
Wending Teng, Jianfeng Xiao, Qian Xu, Penghao Li
Varicocele can lead to impaired semen parameters and induce infertility. Varicocelectomy is considered the gold standard for varicocele treatment. However, its impact on improving assisted reproductive technologies (ARTs) outcomes remains contentious. This study seeks to compare reproductive outcomes between infertile men who underwent varicocelectomy and those who did not prior to ARTs. In addition, it evaluates the influence of types of fertilization, couples' ages, and treatment years on clinical pregnancy rates. A comprehensive search was conducted through February 2023 across eight electronic databases using combinations of relevant keywords. Observational and randomized controlled trials (RCTs) were included. Fourteen eligible studies (n = 1,705) were included: 12 retrospective studies (n = 1,467) and 2 prospective studies (n = 238). Pooled results indicated that infertile men who received varicocelectomy had a significantly higher clinical pregnancy rate compared to the control group (OR: 1.38, 95% CI [1.05, 1.83]; I2 = 36%, p = .02). The live birth rate was also significantly higher in the treatment group (OR: 2.18, [1.58, 3.01]; p < .00001; I2 = 0%). However, miscarriage rates did not significantly differ (OR: 1.07; [0.57, 1.98]; I2 = 0%, p = .84). Varicocelectomy significantly improved sperm concentration and normal morphology rate, but did not result in a significant enhancement in sperm motility. Men who underwent varicocelectomy between 2012 and 2019 and subsequently received intracytoplasmic sperm injection exhibited improved outcomes, particularly when their female partners were under 30 years of age. Larger, high-quality RCTs are needed to clarify benefits or avoid unnecessary treatments.
精索静脉曲张可导致精液参数受损并诱发不孕症。精索静脉曲张切除术被认为是精索静脉曲张治疗的金标准。然而,它对改善辅助生殖技术(ARTs)结果的影响仍然存在争议。本研究旨在比较接受精索静脉曲张切除术的不育男性和未接受art治疗的不育男性的生殖结果。此外,它还评估了受精类型、夫妇年龄和治疗年限对临床妊娠率的影响。到2023年2月,我们使用相关关键词组合在8个电子数据库中进行了全面搜索。纳入观察性和随机对照试验(rct)。纳入14项符合条件的研究(n = 1705): 12项回顾性研究(n = 1467)和2项前瞻性研究(n = 238)。汇总结果显示,接受精索静脉曲张切除术的不育男性临床妊娠率明显高于对照组(OR: 1.38, 95% CI [1.05, 1.83];I2 = 36%, p = 0.02)。治疗组活产率也显著高于对照组(OR: 2.18, [1.58, 3.01];I2 = 0%)。然而,流产率没有显著差异(OR: 1.07;[0.57, 1.98];I2 = 0%, p = 0.84)。精索静脉曲张切除术显著提高了精子浓度和正常形态率,但精子活力没有显著提高。在2012年至2019年期间接受精索静脉曲张切除术并随后接受卵胞浆内单精子注射的男性表现出改善的结果,特别是当他们的女性伴侣年龄在30岁以下时。需要更大规模、高质量的随机对照试验来阐明益处或避免不必要的治疗。
{"title":"Influence of Varicocelectomy on Assisted Reproductive Technology Outcomes of Infertile Patients with Varicocele: A Systematic Review and Meta-Analysis.","authors":"Wending Teng, Jianfeng Xiao, Qian Xu, Penghao Li","doi":"10.1177/15579883251334561","DOIUrl":"10.1177/15579883251334561","url":null,"abstract":"<p><p>Varicocele can lead to impaired semen parameters and induce infertility. Varicocelectomy is considered the gold standard for varicocele treatment. However, its impact on improving assisted reproductive technologies (ARTs) outcomes remains contentious. This study seeks to compare reproductive outcomes between infertile men who underwent varicocelectomy and those who did not prior to ARTs. In addition, it evaluates the influence of types of fertilization, couples' ages, and treatment years on clinical pregnancy rates. A comprehensive search was conducted through February 2023 across eight electronic databases using combinations of relevant keywords. Observational and randomized controlled trials (RCTs) were included. Fourteen eligible studies (<i>n</i> = 1,705) were included: 12 retrospective studies (<i>n</i> = 1,467) and 2 prospective studies (<i>n</i> = 238). Pooled results indicated that infertile men who received varicocelectomy had a significantly higher clinical pregnancy rate compared to the control group (OR: 1.38, 95% CI [1.05, 1.83]; <i>I</i><sup>2</sup> = 36%, <i>p</i> = .02). The live birth rate was also significantly higher in the treatment group (OR: 2.18, [1.58, 3.01]; <i>p</i> < .00001; <i>I</i><sup>2</sup> = 0%). However, miscarriage rates did not significantly differ (OR: 1.07; [0.57, 1.98]; <i>I</i><sup>2</sup> = 0%, <i>p</i> = .84). Varicocelectomy significantly improved sperm concentration and normal morphology rate, but did not result in a significant enhancement in sperm motility. Men who underwent varicocelectomy between 2012 and 2019 and subsequently received intracytoplasmic sperm injection exhibited improved outcomes, particularly when their female partners were under 30 years of age. Larger, high-quality RCTs are needed to clarify benefits or avoid unnecessary treatments.</p>","PeriodicalId":7429,"journal":{"name":"American Journal of Men's Health","volume":"19 2","pages":"15579883251334561"},"PeriodicalIF":2.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12038214/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143952166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-03-01Epub Date: 2025-03-18DOI: 10.1177/15579883251324038
Helmi Ben Saad
{"title":"Comments on \"Modulation of NRF2 and CYP24A1 Pathways by Hookah Smoke: Implications for Male Reproductive Health\".","authors":"Helmi Ben Saad","doi":"10.1177/15579883251324038","DOIUrl":"10.1177/15579883251324038","url":null,"abstract":"","PeriodicalId":7429,"journal":{"name":"American Journal of Men's Health","volume":"19 2","pages":"15579883251324038"},"PeriodicalIF":2.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11915322/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143655840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-03-01Epub Date: 2025-04-15DOI: 10.1177/15579883251332731
Kebin Meng
This study aimed to investigate the effects of different timing of branched-chain amino acid (BCAA) supplementation (pre-/post-exercise) on the recovery of delayed-onset muscle soreness (DOMS) and associated inflammatory factors after resistance training. A double-blind randomized controlled experimental design was used in this study. Twenty-four untrained male college students volunteered to receive BCAA supplementation and completed resistance training. Participants were randomly assigned to the BCAA and placebo groups and sequentially performed two experiments of pre-exercise supplementation and post-exercise supplementation. Thus, four groups were formed: the BCAA-PRE group, the BCAA-POST group, the PLCB-PRE group, and the PLCB-POST group. Muscle soreness, countermovement jump (CMJ), and related blood parameters [interleukin-6 (IL-6), C-reactive protein (CRP), creatine kinase (CK), blood lactate (B[La])] were measured 30 min, 24 and 48 hr after resistance training. BCAA post-exercise supplementation significantly reduced muscle soreness scores compared to the placebo group at 48 hr after resistance training (p < .05). At 24 hr after resistance training, the BCAA group significantly reduced serum IL-6 and CRP (p < .05), in addition, the BCAA-POST group had lower serum IL-6 and CRP than the BCAA-PRE group (p < .05). No significant difference between groups was detected for CMJ or B[La] (p > .05). Resistance training induced the development of DOMS accompanied by elevated inflammatory factors (CRP and IL-6) and muscle proteins (CK). Compared to pre-exercise BCAA supplementation, post-exercise supplementation was observed to be more effective in alleviating the symptoms of DOMS and reducing inflammatory factors. However, it does not change the state of neuromuscular recovery.
本研究旨在探讨不同时间(运动前/运动后)补充支链氨基酸(BCAA)对阻力训练后迟发性肌肉酸痛(DOMS)及相关炎症因子恢复的影响。本研究采用双盲随机对照实验设计。24名未经训练的男性大学生自愿接受BCAA补充并完成阻力训练。参与者被随机分配到BCAA组和安慰剂组,并依次进行运动前补充和运动后补充两个实验。这样就形成了四组:BCAA-PRE组、BCAA-POST组、PLCB-PRE组和PLCB-POST组。在抗阻训练后30分钟、24小时和48小时测量肌肉酸痛、反动作跳跃(CMJ)及相关血液参数[白细胞介素-6 (IL-6)、c -反应蛋白(CRP)、肌酸激酶(CK)、血乳酸(B[La])]。在抗阻训练后48小时,与安慰剂组相比,运动后补充BCAA显著降低了肌肉酸痛评分(p pp p >.05)。阻力训练诱导迟发性迟发性肌肉酸痛,并伴有炎症因子(CRP和IL-6)和肌肉蛋白(CK)升高。与运动前补充BCAA相比,运动后补充被观察到在缓解DOMS症状和减少炎症因子方面更有效。然而,它并没有改变神经肌肉恢复的状态。
{"title":"Effect of Timing of Branched-Chain Amino Acid Supplementation on Muscle Recovery after Resistance Training in Healthy Males.","authors":"Kebin Meng","doi":"10.1177/15579883251332731","DOIUrl":"https://doi.org/10.1177/15579883251332731","url":null,"abstract":"<p><p>This study aimed to investigate the effects of different timing of branched-chain amino acid (BCAA) supplementation (pre-/post-exercise) on the recovery of delayed-onset muscle soreness (DOMS) and associated inflammatory factors after resistance training. A double-blind randomized controlled experimental design was used in this study. Twenty-four untrained male college students volunteered to receive BCAA supplementation and completed resistance training. Participants were randomly assigned to the BCAA and placebo groups and sequentially performed two experiments of pre-exercise supplementation and post-exercise supplementation. Thus, four groups were formed: the BCAA-PRE group, the BCAA-POST group, the PLCB-PRE group, and the PLCB-POST group. Muscle soreness, countermovement jump (CMJ), and related blood parameters [interleukin-6 (IL-6), C-reactive protein (CRP), creatine kinase (CK), blood lactate (B[La])] were measured 30 min, 24 and 48 hr after resistance training. BCAA post-exercise supplementation significantly reduced muscle soreness scores compared to the placebo group at 48 hr after resistance training (<i>p</i> < .05). At 24 hr after resistance training, the BCAA group significantly reduced serum IL-6 and CRP (<i>p</i> < .05), in addition, the BCAA-POST group had lower serum IL-6 and CRP than the BCAA-PRE group (<i>p</i> < .05). No significant difference between groups was detected for CMJ or B[La] (<i>p</i> > .05). Resistance training induced the development of DOMS accompanied by elevated inflammatory factors (CRP and IL-6) and muscle proteins (CK). Compared to pre-exercise BCAA supplementation, post-exercise supplementation was observed to be more effective in alleviating the symptoms of DOMS and reducing inflammatory factors. However, it does not change the state of neuromuscular recovery.</p>","PeriodicalId":7429,"journal":{"name":"American Journal of Men's Health","volume":"19 2","pages":"15579883251332731"},"PeriodicalIF":2.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12033860/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143959939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-03-01Epub Date: 2025-04-20DOI: 10.1177/15579883251325478
Li-Xing Lei, Ke-Cheng Li, Wen-Hao Yu, Jun-Long Feng, Hua-Nan Zhang, Mao-Ke Chen, Wen-Xuan Dong, Ji-Xuan Chen, Jie Li, Ji-Sheng Wang, Liang Han, Bin Wang
This study aims to analyze the registration information and outcome transparency for five common andrological diseases, as well as the factors influencing result availability. A comprehensive search was performed on ClinicalTrials.gov and the International Clinical Trials Registry Platform (ICTRP) to retrieve all clinical trial registration data related to the five defined andrological diseases from the inception of these databases up to September 1, 2024. The search extracted key trial details, including status, type, intervention, and result availability. Of 8,132 trials retrieved, 642 were analyzed. Among these, 259 trials (40.34%) reported results via ClinicalTrials.gov, ICTRP, or publications, while 113 trials (17.60%) made results publicly available on ClinicalTrials.gov or ICTRP. Among the five andrological diseases, male infertility had the highest rate of result availability (37/74, 50%), whereas benign prostatic hyperplasia exhibited the lowest (71/190, 37.37%). No significant differences were found across diseases (χ2 = 3.722, df = 4, p = .435). Factors such as study status, blinding, interventions, center type, location, and duration significantly influenced result availability, whereas study type, stage, funding, outcome indicators, and sample size did not. Clinical trials on andrological conditions show major gaps in registration and result disclosure, with low reporting rates and prevalent non-reporting and selective reporting. Developed countries dominate trial registration and result disclosure while developing countries have limited participation. Trial characteristics also influence result disclosure rates. These challenges compromise the integrity and credibility of research data, impede clinical practice, and hinder the progress of medical research. Measures are needed to improve transparency, reduce selective reporting, and enhance the rigor and credibility of andrology research.
{"title":"Analysis of Current Status of Clinical Trial Registrations in Andrological Diseases: Insights from ClinicalTrials.gov and ICTRP Databases.","authors":"Li-Xing Lei, Ke-Cheng Li, Wen-Hao Yu, Jun-Long Feng, Hua-Nan Zhang, Mao-Ke Chen, Wen-Xuan Dong, Ji-Xuan Chen, Jie Li, Ji-Sheng Wang, Liang Han, Bin Wang","doi":"10.1177/15579883251325478","DOIUrl":"https://doi.org/10.1177/15579883251325478","url":null,"abstract":"<p><p>This study aims to analyze the registration information and outcome transparency for five common andrological diseases, as well as the factors influencing result availability. A comprehensive search was performed on ClinicalTrials.gov and the International Clinical Trials Registry Platform (ICTRP) to retrieve all clinical trial registration data related to the five defined andrological diseases from the inception of these databases up to September 1, 2024. The search extracted key trial details, including status, type, intervention, and result availability. Of 8,132 trials retrieved, 642 were analyzed. Among these, 259 trials (40.34%) reported results via ClinicalTrials.gov, ICTRP, or publications, while 113 trials (17.60%) made results publicly available on ClinicalTrials.gov or ICTRP. Among the five andrological diseases, male infertility had the highest rate of result availability (37/74, 50%), whereas benign prostatic hyperplasia exhibited the lowest (71/190, 37.37%). No significant differences were found across diseases (χ<sup>2</sup> = 3.722, <i>df</i> = 4, <i>p</i> = .435). Factors such as study status, blinding, interventions, center type, location, and duration significantly influenced result availability, whereas study type, stage, funding, outcome indicators, and sample size did not. Clinical trials on andrological conditions show major gaps in registration and result disclosure, with low reporting rates and prevalent non-reporting and selective reporting. Developed countries dominate trial registration and result disclosure while developing countries have limited participation. Trial characteristics also influence result disclosure rates. These challenges compromise the integrity and credibility of research data, impede clinical practice, and hinder the progress of medical research. Measures are needed to improve transparency, reduce selective reporting, and enhance the rigor and credibility of andrology research.</p>","PeriodicalId":7429,"journal":{"name":"American Journal of Men's Health","volume":"19 2","pages":"15579883251325478"},"PeriodicalIF":2.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12035042/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143965874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
This study investigates the multifaceted factors influencing adjustment to prostate cancer among older men in Esfahan, Iran, using the social ecological model (SEM) as a guiding framework. We employed a qualitative approach, conducting semistructured interviews with 19 men diagnosed with prostate cancer, aged 63 to 92 years (mean age = 71), and six key informants, including spouses and health care professionals. We thematically analyzed the data to identify challenges and facilitators in the intrapersonal, interpersonal, and environmental domains of the SEM. The findings revealed a dynamic interplay of factors shaping the adjustment process. Intrapersonal challenges included physical degeneration, psychological distress, stigma, and role reversal, countered by coping strategies such as adopting healthy habits and spirituality. Interpersonal dynamics encompassed family strain and denial, yet the presence of familial support and self-care significantly enhanced adjustment. On an environmental level, financial burdens and health care barriers posed significant challenges. The study furthermore highlighted critical issues like "dysmedication" and "body occupation" which impede effective coping. A complex network of personal, relational, and systemic factors influences the adjustment to prostate cancer among older Iranian men. We urgently need tailored, culturally sensitive interventions to address health care inequities, alleviate economic pressures, and enhance psychosocial support networks, thereby empowering older adults to navigate this challenging journey with greater resilience and dignity.
{"title":"A Qualitative Exploration of Factors Influencing Prostate Cancer Adjustment Among Older Adults: A Social Ecological Model.","authors":"Mehdi Nakhodaeezadeh, Reza Fadayevatan, Mahshid Foroughan, Fatemeh Raeesi Dehkordi, Nasibeh Zanjari","doi":"10.1177/15579883251315177","DOIUrl":"10.1177/15579883251315177","url":null,"abstract":"<p><p>This study investigates the multifaceted factors influencing adjustment to prostate cancer among older men in Esfahan, Iran, using the social ecological model (SEM) as a guiding framework. We employed a qualitative approach, conducting semistructured interviews with 19 men diagnosed with prostate cancer, aged 63 to 92 years (mean age = 71), and six key informants, including spouses and health care professionals. We thematically analyzed the data to identify challenges and facilitators in the intrapersonal, interpersonal, and environmental domains of the SEM. The findings revealed a dynamic interplay of factors shaping the adjustment process. Intrapersonal challenges included physical degeneration, psychological distress, stigma, and role reversal, countered by coping strategies such as adopting healthy habits and spirituality. Interpersonal dynamics encompassed family strain and denial, yet the presence of familial support and self-care significantly enhanced adjustment. On an environmental level, financial burdens and health care barriers posed significant challenges. The study furthermore highlighted critical issues like \"dysmedication\" and \"body occupation\" which impede effective coping. A complex network of personal, relational, and systemic factors influences the adjustment to prostate cancer among older Iranian men. We urgently need tailored, culturally sensitive interventions to address health care inequities, alleviate economic pressures, and enhance psychosocial support networks, thereby empowering older adults to navigate this challenging journey with greater resilience and dignity.</p>","PeriodicalId":7429,"journal":{"name":"American Journal of Men's Health","volume":"19 2","pages":"15579883251315177"},"PeriodicalIF":2.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11905018/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143613004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}