Pramod Kumar, Poonam Varma Shivkumar, M. Barambhe, M. Bathla, J. Lowe, T. Khokhar, Samita Bharadwaj, Vinay Jain
{"title":"E-Partography- A Rural Tertiary Hospital Experience","authors":"Pramod Kumar, Poonam Varma Shivkumar, M. Barambhe, M. Bathla, J. Lowe, T. Khokhar, Samita Bharadwaj, Vinay Jain","doi":"10.26502/ogr024","DOIUrl":"https://doi.org/10.26502/ogr024","url":null,"abstract":"","PeriodicalId":74336,"journal":{"name":"Obstetrics and gynecology research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69352687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Elsirgany, H. Badawi, Z. El-khayat, M. Bibers, M. Hamdy, A. Hamdy, S. Salama, Rehab A. Lotfy, M. Alalfy
Objective: Fetuin-A is a glycoprotein which is present in circulation that might be linked to insulin resistance and polycystic ovary syndrome (PCOS). The aim of our study was to investigate the changes in Fetuin-A levels as a possible marker in patients with PCOS. Methods: In this study we included a total of 80 women. Group A;40 women with PCOS represented this study group, while another 40 women with regular cycles and no symptoms of hyperandrogenemia represented the controls(Group B). Fetuin-A level was measured in both groups to compare the level of this hormone. Results: Our results showed that Fetuin A concentration in the PCOS group was elevated than the control group (mean ± SD: 521 ± 7.1 vs 505 ± 50.5 ng/ml respectively) and the difference was statistically significant. Conclusions: Fetuin A level could be proposed as a screening test for PCOS with a cutoff value of 515 ng/ ml, the sensitivity and specificity were one hundred % and forty five %, respectively.
目的:胎儿素a是一种存在于血液循环中的糖蛋白，可能与胰岛素抵抗和多囊卵巢综合征(PCOS)有关。我们研究的目的是探讨胎儿素a水平的变化作为多囊卵巢综合征患者可能的标志物。方法:本研究共纳入80名女性。A组:40名患有多囊卵巢综合征的女性代表该研究组，而另外40名月经规律且无高雄激素血症症状的女性代表对照组(B组)。测量两组的胎儿激素A水平以比较该激素水平。结果:PCOS组Fetuin A浓度较对照组升高(mean±SD: 521±7.1 vs 505±50.5 ng/ml)，差异有统计学意义。结论:胎儿素A水平可作为PCOS筛查指标，临界值为515 ng/ ml，敏感性为100%，特异性为45%。
{"title":"Serum Fetuin a Level: A New Possible Marker for Polycystic Ovarian Syndrome in Women with Infertility","authors":"S. Elsirgany, H. Badawi, Z. El-khayat, M. Bibers, M. Hamdy, A. Hamdy, S. Salama, Rehab A. Lotfy, M. Alalfy","doi":"10.26502/ogr027","DOIUrl":"https://doi.org/10.26502/ogr027","url":null,"abstract":"Objective: Fetuin-A is a glycoprotein which is present in circulation that might be linked to insulin resistance and polycystic ovary syndrome (PCOS). The aim of our study was to investigate the changes in Fetuin-A levels as a possible marker in patients with PCOS. Methods: In this study we included a total of 80 women. Group A;40 women with PCOS represented this study group, while another 40 women with regular cycles and no symptoms of hyperandrogenemia represented the controls(Group B). Fetuin-A level was measured in both groups to compare the level of this hormone. Results: Our results showed that Fetuin A concentration in the PCOS group was elevated than the control group (mean ± SD: 521 ± 7.1 vs 505 ± 50.5 ng/ml respectively) and the difference was statistically significant. Conclusions: Fetuin A level could be proposed as a screening test for PCOS with a cutoff value of 515 ng/ ml, the sensitivity and specificity were one hundred % and forty five %, respectively.","PeriodicalId":74336,"journal":{"name":"Obstetrics and gynecology research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69352262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Labour pain described as ‘the most horrible’ affects both physiological and psychological aspects of labour. Thus, the provision of labour analgesia is of paramount importance to better both maternal and neonatal outcomes. In our country, majority of obstetric services are in the hands of trained nurses and non-specialized doctors and thus awareness and acceptance of pain-relieving for women in labour virtually does not exist. Therefore, drugs like paracetamol and tramadol with advantage of easy availability, being inexpensive with no special technique of administration are a boon for labour analgesia. Objective: To compare the role of intravenous paracetamol versus intravenous tramadol as an intrapartum labour analgesic. Materials and methods: A total of 273 primigravidae with term gestation with singleton pregnancy with vertex presentation in active phase of labour with cervical dilatation ≥ 4cm with spontaneous onset of labour were taken who satisfied the inclusion and exclusion criteria of the study. Group P (141 women) and Group T (132 women) received 100 ml intravenous infusion containing 1 gram of paracetamol single dose and 100 mg of tramadol hydrochloride diluted in 100 ml normal saline over 15 minutes respectively. Visual Analogue scale (VAS) was used to assess pain intensity, before administering drug, after 1 and 3 hours of drug administration. The primary outcomes measured were difference in VAS score in both groups. The secondary outcomes analysed were mode of delivery, duration of labour, drug-delivery interval, maternal side effects and neonatal outcomes in terms of birth weight, APGAR scores and NICU admissions. Results: The mean VAS score decreased significantly to a greater extent in group P than group T and showed a significant statistical difference among both the groups (p < 0.001). In both the groups, the difference in the VAS score was statistically significant (p<0.05). The duration of labour was statistically shorter in group P (p< 0.0001). The participants in group T had more incidence of maternal side-effects and 7 NICU admission than in paracetamol group. Conclusion: Intravenous paracetamol with better analgesic efficacy, shorter duration of labour and fewer maternal side effects is a more effective labour analgesic than tramadol.
{"title":"A Randomized Controlled Trial of Intravenous Paracetamol and Intravenous Tramadol for Labour Analgesia","authors":"N. Garg, Vanitha Vg","doi":"10.26502/ogr017","DOIUrl":"https://doi.org/10.26502/ogr017","url":null,"abstract":"Background: Labour pain described as ‘the most horrible’ affects both physiological and psychological aspects of labour. Thus, the provision of labour analgesia is of paramount importance to better both maternal and neonatal outcomes. In our country, majority of obstetric services are in the hands of trained nurses and non-specialized doctors and thus awareness and acceptance of pain-relieving for women in labour virtually does not exist. Therefore, drugs like paracetamol and tramadol with advantage of easy availability, being inexpensive with no special technique of administration are a boon for labour analgesia. Objective: To compare the role of intravenous paracetamol versus intravenous tramadol as an intrapartum labour analgesic. Materials and methods: A total of 273 primigravidae with term gestation with singleton pregnancy with vertex presentation in active phase of labour with cervical dilatation ≥ 4cm with spontaneous onset of labour were taken who satisfied the inclusion and exclusion criteria of the study. Group P (141 women) and Group T (132 women) received 100 ml intravenous infusion containing 1 gram of paracetamol single dose and 100 mg of tramadol hydrochloride diluted in 100 ml normal saline over 15 minutes respectively. Visual Analogue scale (VAS) was used to assess pain intensity, before administering drug, after 1 and 3 hours of drug administration. The primary outcomes measured were difference in VAS score in both groups. The secondary outcomes analysed were mode of delivery, duration of labour, drug-delivery interval, maternal side effects and neonatal outcomes in terms of birth weight, APGAR scores and NICU admissions. Results: The mean VAS score decreased significantly to a greater extent in group P than group T and showed a significant statistical difference among both the groups (p < 0.001). In both the groups, the difference in the VAS score was statistically significant (p<0.05). The duration of labour was statistically shorter in group P (p< 0.0001). The participants in group T had more incidence of maternal side-effects and 7 NICU admission than in paracetamol group. Conclusion: Intravenous paracetamol with better analgesic efficacy, shorter duration of labour and fewer maternal side effects is a more effective labour analgesic than tramadol.","PeriodicalId":74336,"journal":{"name":"Obstetrics and gynecology research","volume":"57 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69352626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aim: The aim of the study was to determine the prevalence of abnormal uterine bleeding and its various patterns from the gynecologists across the country and the preferred therapy in the management of AUB. Material and Methods: The survey was conducted amongst 141 gynecologists across the country. Information was collected by filling up a questionnaire that contained information regarding menstrual cycle irregularities, preferred therapy and alternatives which can be preferred over hormonal prescriptions in case of therapy failure. Statistical data analysis was performed with Microsoft excel 2010 and expressed in percentages. Results: Prevalence of AUB as per this survey is in line with the global data which states that overall prevalence fluctuates in between 10-30%. In this survey, doctors reported 32.72% of females visit their clinic due to AUB. Females of reproductive age group accounted for a major percentage of menstrual irregularities and the most common condition quoted was menorrhagia in 16.06%. Doctors also shared their experience in terms of preferred therapy in the management of AUB and also the percentage of discontinuation/refusal by females for hormonal therapy. Conclusion: The result of the study concluded that significant number of female have issue of abnormal uterine bleeding and limitations of existing therapy leading to discontinuation/refusal opens the door for exploring still safer options in managing AUB.
{"title":"Abnormal Uterine Bleeding: A Doctor Centric Survey on Prevalence, Management and Limitations in Indian Context","authors":"Arif A Faruqui","doi":"10.26502/ogr022","DOIUrl":"https://doi.org/10.26502/ogr022","url":null,"abstract":"Aim: The aim of the study was to determine the prevalence of abnormal uterine bleeding and its various patterns from the gynecologists across the country and the preferred therapy in the management of AUB. Material and Methods: The survey was conducted amongst 141 gynecologists across the country. Information was collected by filling up a questionnaire that contained information regarding menstrual cycle irregularities, preferred therapy and alternatives which can be preferred over hormonal prescriptions in case of therapy failure. Statistical data analysis was performed with Microsoft excel 2010 and expressed in percentages. Results: Prevalence of AUB as per this survey is in line with the global data which states that overall prevalence fluctuates in between 10-30%. In this survey, doctors reported 32.72% of females visit their clinic due to AUB. Females of reproductive age group accounted for a major percentage of menstrual irregularities and the most common condition quoted was menorrhagia in 16.06%. Doctors also shared their experience in terms of preferred therapy in the management of AUB and also the percentage of discontinuation/refusal by females for hormonal therapy. Conclusion: The result of the study concluded that significant number of female have issue of abnormal uterine bleeding and limitations of existing therapy leading to discontinuation/refusal opens the door for exploring still safer options in managing AUB.","PeriodicalId":74336,"journal":{"name":"Obstetrics and gynecology research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69352678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objectives: The aim of this study was to assess the relation between different abnormalities of the yolk sac, serum level of Cancer Antigen 125 (CA-125) and serum level of Beta Human Chorionic Gonadotropin (β –HCG) as early predictors of first trimester pregnancy loss in patients with threatened miscarriage. Methods: This prospective observational study was conducted on 292 pregnant women between six to 13 weeks of gestation who were suffered threatened miscarriage. Visualization of yolk sac and diameter were recorded by transvaginal ultrasound . Maternal serum CA-125 and β HCG were also measured. Pregnancy outcome was the main outcome measure. Data was collected and tabulated. Results: There was highly Significant relation between YS size and pregnancy outcome (P<0.001). CA-125 and β-HCG were good predictors of miscarriage with accuracy 88%and 81.5% respectively. Conclusions: Yolk sac size and maternal serum CA-125 and β-HCG are good predictors of pregnancy outcome in first trimester threatened miscarriage.
{"title":"Ultrasonic and Laboratory Predictors of Pregnancy Loss in Patients with Threatened Miscarriage: A Three-Year Observational Study","authors":"A. Salah","doi":"10.26502/ogr025","DOIUrl":"https://doi.org/10.26502/ogr025","url":null,"abstract":"Objectives: The aim of this study was to assess the relation between different abnormalities of the yolk sac, serum level of Cancer Antigen 125 (CA-125) and serum level of Beta Human Chorionic Gonadotropin (β –HCG) as early predictors of first trimester pregnancy loss in patients with threatened miscarriage. Methods: This prospective observational study was conducted on 292 pregnant women between six to 13 weeks of gestation who were suffered threatened miscarriage. Visualization of yolk sac and diameter were recorded by transvaginal ultrasound . Maternal serum CA-125 and β HCG were also measured. Pregnancy outcome was the main outcome measure. Data was collected and tabulated. Results: There was highly Significant relation between YS size and pregnancy outcome (P<0.001). CA-125 and β-HCG were good predictors of miscarriage with accuracy 88%and 81.5% respectively. Conclusions: Yolk sac size and maternal serum CA-125 and β-HCG are good predictors of pregnancy outcome in first trimester threatened miscarriage.","PeriodicalId":74336,"journal":{"name":"Obstetrics and gynecology research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69352247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: To present case report a patient with clitoral cyst, following type II female genital cutting performed in childhood, management and literature review. Design: Report of cases managed and review of available current literatures. Setting: University College Hospital Ibadan. Patients: The case was a 30 year old Para 2+0 , 2 alive, known hypertensive, with perineal swelling since childhood. She presented 30 years later with increasing size of the clitoral swelling associated with pain. Management: Surgical excision of the cyst following thorough evaluation of the patients. Results: Better cosmetic outcome, vulvar discomfort subsided and improved sexual satisfaction post-operatively. Conclusion: While a good cosmetic and stoppage of vulvar discomfort can be managed with acceptable outcomes, these case, again, brings to attention of persistence of unacceptable female genital cutting with attendant effects even in the 21st century. Also, to let us know that there is need for more and continuous awareness creation of the need to stop this dehumanizing practice, of female genital cutting, which is of no health importance, rather numerous adverse sequelae.
{"title":"Acquired Clitoromegaly Cyst: Consequence of Persistent Unorthodox Practice in the 21st Century","authors":"O. Awolude, Oluyomi Akinyotu","doi":"10.26502/ogr020","DOIUrl":"https://doi.org/10.26502/ogr020","url":null,"abstract":"Objective: To present case report a patient with clitoral cyst, following type II female genital cutting performed in childhood, management and literature review. Design: Report of cases managed and review of available current literatures. Setting: University College Hospital Ibadan. Patients: The case was a 30 year old Para 2+0 , 2 alive, known hypertensive, with perineal swelling since childhood. She presented 30 years later with increasing size of the clitoral swelling associated with pain. Management: Surgical excision of the cyst following thorough evaluation of the patients. Results: Better cosmetic outcome, vulvar discomfort subsided and improved sexual satisfaction post-operatively. Conclusion: While a good cosmetic and stoppage of vulvar discomfort can be managed with acceptable outcomes, these case, again, brings to attention of persistence of unacceptable female genital cutting with attendant effects even in the 21st century. Also, to let us know that there is need for more and continuous awareness creation of the need to stop this dehumanizing practice, of female genital cutting, which is of no health importance, rather numerous adverse sequelae.","PeriodicalId":74336,"journal":{"name":"Obstetrics and gynecology research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69352668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"ES-2 Ovarian Cancer Cells Present a Genomic Profile Inconsistent with their Reported History","authors":"Eric J Devor, Jace R Lapierre, David P Bender","doi":"10.26502/ogr072","DOIUrl":"https://doi.org/10.26502/ogr072","url":null,"abstract":"","PeriodicalId":74336,"journal":{"name":"Obstetrics and gynecology research","volume":"82 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69352319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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