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A Triad Study in South Indian Population of Telangana: On the Association of Cytokine Gene Polymorphisms in the Aetiology of Spontaneous Abortions 南印度特伦甘纳人口的三合一研究:细胞因子基因多态性与自然流产病因的关系
Pub Date : 2021-01-01 DOI: 10.26502/ogr071
Renjini Devi MR, Shehnaz Sultana, V. M, Rambabu Sp, P. Nallari, Venkateshwari A
Background: Spontaneous abortion is defined as the loss of two or more consecutive pregnancies before 20 week of gestation. About 50% of the cases are remained with unexplained etiology. Potential immune cell differentiation and cytokine profile is detrimental for fetal-maternal communication and maternal recognition of pregnancy. An imbalance in the immune modulatory profile results in consecutive loss of pregnancies. In view of the above, the present study is taken up to understand the role of immunemodulators and their gene polymorphism in the etiology of spontaneous abortion. Methods: In the present case-control triad study genotyping for IFN γ+874 T/A, IL6-137 G/C, IL18174G/C polymorphisms were done by Amplified Refractory Mutation System polymerase chain reaction method (ARMS-PCR) and statistically analyzed. Result: A retrospective analysis for association of gene polymorphisms in the present study showed that Obstet Gynecol Res 2021; 4 (4): 220-232 DOI: 10.26502/ogr071 Obstetrics and Gynecology Research Vol. 4 No. 4– December 2021. 221 maternal and fetal TT genotype of IFN γ+874 polymorphism showed a twofold increased risk (OR 2.22, 95%CI= 1.29-3.84, p=0.004) whereas in IL 18 174G/C gene polymorphism and their association study, the case mother subjects that represented CC genotypes contributed a onefold increased risk towards the development of spontaneous abortion. (OR -2.17, 95%CI1.250-3.788, p=0.005) Conclusion: The proinflammatory and anti-inflammatory gene polymorphisms may contribute towards the susceptibility for spontaneous abortion.
背景:自然流产是指在妊娠20周之前连续两次或两次以上流产。约50%的病例病因不明。潜在的免疫细胞分化和细胞因子谱不利于胎儿与母体的沟通和母体对妊娠的识别。免疫调节谱的不平衡导致连续流产。鉴于上述,本研究旨在了解免疫调节剂及其基因多态性在自然流产病因学中的作用。方法:采用扩增难解突变系统聚合酶链反应法(ARMS-PCR)对IFN γ+874 T/A、IL6-137 G/C、IL18174G/C多态性进行基因分型,并进行统计学分析。结果:对本研究中基因多态性相关性的回顾性分析显示,《妇产科杂志》2021;4 (4): 220-232 DOI: 10.26502/ogr071妇产科研究卷4 No. 4 - 2021年12月。221母胎TT基因型IFN γ+874多态性增加了2倍的风险(OR 2.22, 95%CI= 1.29-3.84, p=0.004),而在IL 18 174G/C基因多态性及其相关性研究中,CC基因型的病例母亲受试者发生自然流产的风险增加了1倍。(OR -2.17, 95%CI1.250-3.788, p=0.005)结论:促炎和抗炎基因多态性可能与自然流产易感性有关。
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引用次数: 0
Twelve-Month outcomes of a Cluster-Randomized Trial of Home-Based Postpartum Contraceptive Delivery in Southwest Trifinio, Guatemala. 危地马拉特里菲尼奥西南部一项基于家庭产后避孕的12个月随机分组试验的结果
Pub Date : 2021-01-01 Epub Date: 2021-04-15 DOI: 10.26502/ogr057
Margo S Harrison, Saskia Bunge-Montes, Claudia Rivera, Andrea Jimenez-Zambrano, Gretchen Heinrichs, Antonio Bolanos, Edwin Asturias, Stephen Berman, Jeanelle Sheeder

Design: We executed a cluster-randomized parallel arm pragmatic trial to observe the association of home-based postpartum contraceptive provision, including the contraceptive implant, with three and 12-month contraceptive utilization, satisfaction, and pregnancy rates.

Methods: Eight clusters were randomized to receive either the home-based contraceptive delivery (condoms, pills, injection, implant) during the routine 40-day postpartum visit in addition to routine care, or routine care alone, which included comprehensive contraceptive counseling throughout antepartum care.

Results: 208 women were enrolled in the study, 108 in the intervention clusters and 100 in control clusters. 94 (87.0%) women in the intervention group and 91 (91%) of women in control clusters were evaluated 12 months post-enrollment. Likelihood of using contraception at that time was borderline increased in intervention clusters (RR 1.1 [1.0,1.3], p = 0.05) with an increased likelihood of long-acting contraceptive use (the implant; RR 1.6 [1.3,1.9], p < 0.001). Pregnancy rates were also borderline reduced in the intervention clusters (RR 1.0 [1.0,1.1], p = 0.07). There was no difference in satisfaction of women with contraceptive use between arms with about 95% of women very satisfied or a little satisfied in each arm. Continuation rates at twelve months of contraceptives in the intervention group were 0.0% for condom users, 80.0% for contraceptive pill users, 57% for injectable users, and 83% for implant users. Most women who discontinued their initial method chose a more long-term or permanent method. There was a trend toward a significant association with reduced short interval pregnancy.

Conclusion: Our study had a borderline increase in overall use of contraception by 12 months, did have an increased likelihood of long-acting contraceptive use of the implant by 12 months, and resulted in a trend toward reduced short interval pregnancy in the intervention clusters as compared to control clusters.

设计:我们执行了一项集群随机平行臂实用试验,观察以家庭为基础的产后避孕提供,包括避孕植入物,与3个月和12个月的避孕使用、满意度和妊娠率的关系。方法:8组患者随机分为两组,一组在产后40天的常规随访中,在常规护理的基础上进行家庭避孕(避孕套、避孕丸、注射、植入物),另一组接受常规护理,其中包括产前护理期间的综合避孕咨询。结果:208名妇女参加了研究,干预组108名,对照组100名。干预组94名(87.0%)妇女和对照组91名(91%)妇女在入组12个月后接受评估。当时使用避孕措施的可能性在干预组中呈边缘性增加(RR 1.1 [1.0,1.3], p = 0.05),使用长效避孕措施的可能性增加(植入物;RR为1.6 [1.3,1.9],p < 0.001)。干预组的妊娠率也有降低(RR为1.0 [1.0,1.1],p = 0.07)。两组妇女对避孕药具使用的满意度没有差异,每组约有95%的妇女非常满意或比较满意。在干预组中,安全套使用者的12个月避孕持续率为0.0%,避孕药使用者为80.0%,注射剂使用者为57%,植入物使用者为83%。大多数停止了最初方法的妇女选择了更长期或永久的方法。这一趋势与短间隔妊娠的减少有显著的关联。结论:我们的研究发现,在12个月的时间里,避孕药具的总体使用有一个边缘性的增加,在12个月的时间里,植入物使用长效避孕药具的可能性确实有增加,并且与对照组相比,干预组的短间隔妊娠有减少的趋势。
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引用次数: 0
Wound Care Education for Caesarean Section Clients: What Do Midwifery Students Know? 剖宫产病人的伤口护理教育:助产学学生知道些什么?
Pub Date : 2021-01-01 DOI: 10.26502/ogr067
Angelina Abban Ansu
Background: Complications associated with Caesarean Section (CS) delivery such as surgical site infection (SSIs) are complex. Infection of the CS wound has enormous consequences. A major risk factor associated with CS wound infection is lack of knowledge of CS clients about wound care. The knowledge of trainee midwives is critical if they are to educate CS clients on wound care. Aim: The objective of the study was to explore midwifery students’ knowledge on the education of CS clients on wound care. Materials and methods: This cross-sectional study purposely used 339 final year midwifery students within the Midwifery Training Colleges of Greater Accra Region. Participants answered a questionnaire formulated from relevant literature. Frequencies and percentages analyses were used for the data. Statistical analysis: Stata SE version 13 software. Results: This study revealed that 317 (93.1%), 325 (96%), 320 (94.4%) were knowledgeable about CS, surgical site wound care and education for CS clients on wound care respectively. Again, 286 (84.37%) of the students indicated that their training has equipped them to give education on wound care to CS clients. However, 227 (65.96%), 287 (84.66%), 179 (52.8%) did not have adequate knowledge on aspects of indications for CS delivery, surgical site wound care and education for CS client on wound care, respectively. Conclusions: Majority of the final year midwifery students recorded higher knowledge scores about CS, surgical site wound care and education for CS clients on surgical site wound care. However, quite a number could not respond to aspects of indication for CS delivery and CS wound care.
背景:与剖宫产(CS)相关的并发症,如手术部位感染(ssi)是复杂的。CS伤口感染的后果非常严重。与CS伤口感染相关的一个主要危险因素是CS患者缺乏伤口护理知识。见习助产士的知识是至关重要的,如果他们要教育CS客户的伤口护理。目的:探讨助产学学生对CS客户伤口护理教育的认知情况。材料和方法:这项横断面研究专门使用了大阿克拉地区助产培训学院的339名助产学最后一年的学生。参与者回答了一份根据相关文献制定的问卷。数据采用频率和百分比分析。统计分析:Stata SE版本13软件。结果:317名(93.1%)、325名(96%)、320名(94.4%)分别对CS、手术部位伤口护理和CS患者伤口护理知识有所了解。同样,286名(84.37%)学生表示,他们的培训使他们具备向CS客户提供伤口护理教育的能力。然而,227名(65.96%)、287名(84.66%)、179名(52.8%)对CS分娩指征、手术部位伤口护理和CS病人伤口护理教育方面的知识不足。结论:大多数助产学最后一年的学生对CS、手术部位伤口护理和CS客户手术部位伤口护理的知识得分较高。然而,相当多的患者在CS分娩和CS伤口护理的适应证方面没有反应。
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引用次数: 0
Frequency and Risk Factors for Depression and Anxiety in Patients with Polycystic Ovary Syndrome Presenting in a Tertiary Care Hospital Karachi, Pakistan 巴基斯坦卡拉奇三级医院多囊卵巢综合征患者抑郁和焦虑的频率和危险因素
Pub Date : 2021-01-01 DOI: 10.26502/ogr068
A. Tariq, Manahil Tariq Malik, H. Tariq, Samina Naseem khattak, T. Yazdani, Rameen Tariq Malik, S. Rauf, T. Malik
Objective: To determine the frequency and risk factors for depression and anxiety in patients with Poly cystic ovary syndrome (PCOS). Study design: Comparative Analytic Study. Setting and duration: Department of Obstetrics and Gynaecology at a tertiary care hospital in Karachi, Pakistan from July 2020-December 2020. Materials and methods: All females with diagnosed PCOS aged between 15-45yrs were included in the study .A total of 270 females (n=135) formed the study group. Group A (n=135) constituted females diagnosed to have PCOS and group B (n=135) without PCOS. Obstet Gynecol Res 2021; 4 (4): 196-202 DOI: 10.26502/ogr068 Obstetrics and Gynecology Research Vol. 4 No. 4– December 2021. 197 Both groups were compared for anxiety and depression according to Hospital anxiety and Depression Scale (HADS).Demographic features were compared as well (age, qualification, BMI and parity). Results: A total of 270 females were part of this research (n=135).Most 170 (62.9%) of study population was aged between 21-35years.112 (41.5%) were undergraduate .Most 160 (59.2%) of participants had normal BMI <25kg/m .In group A, 38 (28.1%) had depression along with 43(31.9%) having borderline depression versus 12 (8.9%) had borderline depression in group B, p-value 0.000, which is statistically significant .The overall incidence of anxiety in Group A was 116 (85.9%) versus 50 (37%), p value 0.00 which is statistically significant. Conclusion: Depression and anxiety are common in PCOS. There is strong association of depression with young age (21-35), among graduate women and with no children that is subfertility.
目的:了解多囊卵巢综合征(PCOS)患者抑郁、焦虑的发生频率及其危险因素。研究设计:比较分析研究。地点和时间:2020年7月至2020年12月在巴基斯坦卡拉奇一家三级保健医院的妇产科。材料与方法:所有年龄在15-45岁之间诊断为PCOS的女性纳入研究,共270名女性(n=135)组成研究组。A组(n=135)为诊断为PCOS的女性,B组(n=135)为未诊断为PCOS的女性。妇产科杂志2021;4 (4): 196-202 DOI: 10.26502/ogr068妇产科研究卷4第4期- 2021年12月。197根据医院焦虑抑郁量表(HADS)比较两组的焦虑和抑郁。还比较了人口统计学特征(年龄、资格、BMI和性别平等)。结果:共有270名女性参与了本研究(n=135)。研究人群中年龄在21-35岁之间的170人(62.9%)最多A组有抑郁38人(28.1%),边缘性抑郁43人(31.9%),B组有边缘性抑郁12人(8.9%),p值0.000,差异有统计学意义。A组总焦虑发生率116人(85.9%)比50人(37%),p值0.00,差异有统计学意义。结论:PCOS患者普遍存在抑郁和焦虑。抑郁症与年轻(21-35岁)、大学毕业的女性和没有孩子的低生育能力有很强的联系。
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引用次数: 1
Characteristics Associated with Choosing Long-Acting Reversible Contraception in Rural Guatemala: A Secondary Analysis of a Cluster-Randomized Trial. 危地马拉农村选择长效可逆避孕措施的相关特征:一项集群随机试验的二次分析。
Pub Date : 2021-01-01 Epub Date: 2021-06-25 DOI: 10.26502/ogr062
Margo S Harrison, Saskia Bunge-Montes, Claudia Rivera, Andrea Jimenez-Zambrano, Gretchen Heinrichs, Antonio Bolanos, Edwin Asturias, Stephen Berman, Jeanelle Sheeder

Design: We conducted a secondary analysis of a cluster-randomized trial to observe characteristics associated with women who chose to use long-acting reversible contraceptives (LARC) compared to those who chose a short-acting method 12 months after enrollment.

Methods: The trial studied four control and four intervention clusters where the intervention clusters were offered contraception at their 40-day routine postpartum visit; control clusters received standard care, which included comprehensive postpartum contraceptive counseling. Women were followed through twelve months postpartum.

Results: The study enrolled 208 women; 94 (87.0%) were in the intervention group and 91 (91.0%) were in the control group. At twelve months, with 130 (70.3%) women using contraception at that time. 94 women (50.8%) were using a short acting method compared to 33 (17.9%) who chose a long-acting method, irrespective of cluster. In mixed effect regression modeling adjusted for cluster, characteristics associated with a reduced likelihood of choosing long-acting contraception in multivariate modeling included age (aRR 0.98 [0.96,0.99], p = 0.008) and any education (compared to no education; aRR 0.76 [0.60,0.95], p = 0.02). Women who were sexually active by their enrollment visit (40 days postpartum) were 30% more likely to opt for a long-acting method (aRR 1.30 [1.03,1.63], p = 0.03).

Conclusion: Older and more educated women were less likely to be using LARC a year after enrollment, while women with a history of early postpartum sexual activity were more likely to choose LARC.

设计:我们对一项集群随机试验进行了二次分析,以观察选择长效可逆避孕药(LARC)的妇女与选择短效避孕药的妇女在入组12个月后的相关特征。方法:研究了4个对照组和4个干预组,干预组在产后40天的常规随访中给予避孕措施;对照组接受标准护理,包括全面的产后避孕咨询。这些妇女在产后12个月被跟踪调查。结果:该研究招募了208名女性;干预组94例(87.0%),对照组91例(91.0%)。在12个月时,当时有130名(70.3%)妇女使用避孕措施。94名妇女(50.8%)使用短效方法,而33名妇女(17.9%)选择长效方法,无论分组如何。在经聚类调整的混合效应回归模型中,与多变量模型中选择长效避孕方法可能性降低相关的特征包括年龄(aRR为0.98 [0.96,0.99],p = 0.008)和任何教育程度(与无教育程度相比;aRR为0.76 [0.60,0.95],p = 0.02)。在入组时(产后40天)性活跃的妇女选择长效方法的可能性高出30% (aRR 1.30 [1.03,1.63], p = 0.03)。结论:年龄较大和受教育程度较高的妇女在入组一年后较少使用LARC,而有产后早期性行为史的妇女更有可能选择LARC。
{"title":"Characteristics Associated with Choosing Long-Acting Reversible Contraception in Rural Guatemala: A Secondary Analysis of a Cluster-Randomized Trial.","authors":"Margo S Harrison,&nbsp;Saskia Bunge-Montes,&nbsp;Claudia Rivera,&nbsp;Andrea Jimenez-Zambrano,&nbsp;Gretchen Heinrichs,&nbsp;Antonio Bolanos,&nbsp;Edwin Asturias,&nbsp;Stephen Berman,&nbsp;Jeanelle Sheeder","doi":"10.26502/ogr062","DOIUrl":"https://doi.org/10.26502/ogr062","url":null,"abstract":"<p><strong>Design: </strong>We conducted a secondary analysis of a cluster-randomized trial to observe characteristics associated with women who chose to use long-acting reversible contraceptives (LARC) compared to those who chose a short-acting method 12 months after enrollment.</p><p><strong>Methods: </strong>The trial studied four control and four intervention clusters where the intervention clusters were offered contraception at their 40-day routine postpartum visit; control clusters received standard care, which included comprehensive postpartum contraceptive counseling. Women were followed through twelve months postpartum.</p><p><strong>Results: </strong>The study enrolled 208 women; 94 (87.0%) were in the intervention group and 91 (91.0%) were in the control group. At twelve months, with 130 (70.3%) women using contraception at that time. 94 women (50.8%) were using a short acting method compared to 33 (17.9%) who chose a long-acting method, irrespective of cluster. In mixed effect regression modeling adjusted for cluster, characteristics associated with a reduced likelihood of choosing long-acting contraception in multivariate modeling included age (aRR 0.98 [0.96,0.99], p = 0.008) and any education (compared to no education; aRR 0.76 [0.60,0.95], p = 0.02). Women who were sexually active by their enrollment visit (40 days postpartum) were 30% more likely to opt for a long-acting method (aRR 1.30 [1.03,1.63], p = 0.03).</p><p><strong>Conclusion: </strong>Older and more educated women were less likely to be using LARC a year after enrollment, while women with a history of early postpartum sexual activity were more likely to choose LARC.</p>","PeriodicalId":74336,"journal":{"name":"Obstetrics and gynecology research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8297978/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39223200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pregnancy outcomes at Mizan-Tepi University Teaching Hospital: A Comparison to the Ethiopian Demographic and Health Surveys. 米赞-特皮大学教学医院的妊娠结局:与埃塞俄比亚人口和健康调查的比较
Pub Date : 2021-01-01 Epub Date: 2021-04-14 DOI: 10.26502/ogr056
Margo Shawn Harrison, Margaret Muldrow, Ephrem Kirub, Tewodros Liyew, Biruk Teshome, Andrea Jimenez-Zambrano, Teklemariam Yarinbab

Background: To compare outcomes at Mizan-Tepi University Teaching Hospital to national and regional data and to plan quality improvement and research studies based on the results.

Methods: This study was a prospective hospital-based cross-sectional analysis of a convenience sample of 1, 000 women who delivered at Mizan-Tepi University Teaching Hospital.

Results: Our convenience sample was young (median age 24 years) with a primarily school level or less of education (68.6%). Only about 5% of women had a history of prior cesarean birth, 2.1% reported they were human immunodeficiency virus seropositive, and the median number of prenatal visits was four. Women were commonly admitted in spontaneous labor (84.5%), transferred from another facility (49.2%; 96.8% of which were referred from a health center), and had their fetal heart rate auscultated on admission (94.7%). Only 5.2% of women did not deliver within twenty-four hours and the cesarean birth prevalence was 23.4%. Many women were delivered by midwives (73.2%; all unassisted vaginal births), 89.2% were term deliveries, and 92.5% of neonatal birthweights were 2500 grams or heavier. Less than five percent of women delivered stillbirths (4.3%) and 5.7% of livebirths experienced neonatal death by the day of discharge. There were no maternal deaths in the cohort.

Conclusion: The prevalence of stillbirth and neonatal death were the most notable findings, while there was no maternal death in the cohort.

背景:将米赞特皮大学教学医院的结果与国家和地区数据进行比较,并根据结果计划质量改进和研究。方法:本研究是对在米赞特皮大学教学医院分娩的1000名妇女进行前瞻性的基于医院的横断面分析。结果:我们的方便样本很年轻(中位年龄24岁),受教育程度在初级学校或以下(68.6%)。只有约5%的妇女有剖宫产史,2.1%的妇女报告他们是人类免疫缺陷病毒血清阳性,产前检查的中位数为4次。妇女通常是自然分娩入院(84.5%),从其他机构转移过来(49.2%;其中96.8%是从健康中心转介的),并在入院时听诊胎儿心率(94.7%)。只有5.2%的妇女没有在24小时内分娩,剖宫产率为23.4%。许多妇女由助产士接生(73.2%;89.2%为足月分娩,92.5%的新生儿出生体重为2500克或更重。不到5%的死产妇女(4.3%)和5.7%的活产妇女在出院当天经历了新生儿死亡。该队列中没有产妇死亡。结论:死产和新生儿死亡的发生率是最显著的发现,而队列中没有产妇死亡。
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引用次数: 2
Role of Endometrial Scratching in Implantation Failures 子宫内膜划伤在着床失败中的作用
Pub Date : 2021-01-01 DOI: 10.26502/ogr070
K. Banerjee, B. Singla
Objective: To assess the role of endometrial scratching in implantation failure cases. Design: Retrospective analysis. Materials and Methods: 60 infertile females with at least one IVF failure in the age group of 23 to 35 years were evaluated in a period of 6 months. In the group 1 of 30 females, endometrial scratching was done between Day 21 to 25 of previous periods and in the group 2 of 30 females, endometrial scratching was not done. Controlled ovarian stimulation (COH) was started from day 2 of next period in all subjects with the antagonist protocol. Transvaginal guided oocyte aspiration was done. Day 3 embryo transfer was performed in all subjects. Results: There was no difference between the two groups regarding demographic variables, egg reserve, sperm parameters, number of embryos transferred and embryo quality. The pregnancy rate was 40% (12 out of 30 cases) in the group 1 that was similar to 36.7% in the group 2 (11 out of 30 cases). The clinical pregnancy rate was 36.7% (11 out of 30 cases) in the group 1 that was similar to 33.3% in the group 2 (10 out of 30 cases). Conclusions: The local injury caused by endometrial scratching though result in local inflammation and angiogenic environment in uterus but it does not improve the pregnancy rate. Further studies are needed to prove the efficacy of endometrial scratching with larger sample size. This is one of the few studies done in South Asia that showed scratching has no role in implantation failure.
目的:探讨子宫内膜抓挠在子宫着床失败中的作用。设计:回顾性分析。材料与方法:对年龄在23 ~ 35岁的60例至少有一次IVF失败的不孕女性进行为期6个月的评估。在第一组(30名女性)中,在前一次月经的第21天至第25天之间进行子宫内膜抓挠,而在第二组(30名女性)中,不进行子宫内膜抓挠。所有使用拮抗剂方案的受试者从下一个周期的第2天开始进行控制性卵巢刺激(COH)。经阴道引导卵母细胞抽吸。所有受试者均在第3天进行胚胎移植。结果:两组在人口学变量、卵子储备、精子参数、移植胚胎数量和胚胎质量方面均无差异。1组妊娠率为40%(30例中有12例),2组为36.7%(30例中有11例)。1组临床妊娠率为36.7%(30例中11例),2组临床妊娠率为33.3%(30例中10例)。结论:子宫内膜刮伤引起的局部损伤可引起子宫局部炎症和血管生成环境,但不能提高妊娠率。进一步的研究需要更大的样本量来证明子宫内膜刮擦的有效性。这是在南亚进行的少数几项研究之一,该研究表明抓挠与植入失败无关。
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引用次数: 0
Use of Postpartum Birth Control in Rural Women in Southwest Guatemala: Analysis of a Quality-Improvement Database. 危地马拉西南部农村妇女产后节育的使用:质量改进数据库的分析
Pub Date : 2021-01-01 Epub Date: 2021-10-23 DOI: 10.26502/ogr069
Kathryn Feller, Claudia Rivera, Amy S Nacht, Saskia Bunge-Montes, Andrea Jimenez-Zambrano, Molly Lamb, Gretchen Heinrichs, Antonio Bolanos, Edwin Asturias, Sephen Berman, Margo S Harrison

Objective: Our objective was to observe the prevalence of postpartum contraceptive use in a population of rural women in Southwest Guatemala by type, and to determine characteristics associated with long-acting reversible contraceptive (LARC) use and sterilization.

Methods: We conducted a secondary analysis of prospectively collected quality improvement data from a cohort of postpartum women. We compared women intending to use or already using contraception to those not intending to utilize a method; bivariate comparisons were used to determine if there were differences in characteristics between these groups. If differences occurred (p < 0.2), those covariates were included in multivariable regression analyses to determine characteristics associated with use, and then specifically with LARC use and sterilization.

Results: In a cohort of 424 women who were surveyed between 2015-2017, the average age was 23 years old, and the prevalence of use or plan to use postpartum contraception was 87.5%. Women with a parity of 2 - 3 were 10% more likely to use any form of postpartum birth control (RR 1.1, CI [1.01, 1.2]) compared to primiparous women. Women who were married were also more likely to use a postpartum method (RR > 10, CI [>10,>10]). The prevalence of LARC use was low (4.0%), and women were more likely to choose this method if they were employed (RR 3.5 CI [1.1, 11.3]).Regarding sterilization, women with a parity of greater than one compared to primiparous women had an increased likelihood of sterilization (RR 3.6 CI [2.5,4.9]); each year a woman aged was associated with a 10% increased likelihood of postpartum sterilization (RR 1.1 CI [1.01,1.08]). Women were also more likely to choose sterilization if delivered by a skilled birth attendant (RR 1.8 CI [1.1,2.9]) or by cesarean birth (RR 2.1 CI [1.4,3.1]).

Conclusion: In this cohort, married women of higher parity were more likely to use postpartum contraception, with employed women more likely to use a LARC method. Older women of higher parity who were delivered by a skilled attendant by cesarean birth were the most likely to pursue sterilization.

目的:我们的目的是观察危地马拉西南部农村妇女产后避孕药具的使用情况,并确定长效可逆避孕药具(LARC)使用和绝育的相关特征。方法:我们对一组产后妇女前瞻性收集的质量改善数据进行了二次分析。我们将打算使用或已经使用避孕措施的妇女与不打算使用避孕措施的妇女进行比较;使用双变量比较来确定这些组之间的特征是否存在差异。如果存在差异(p < 0.2),则将这些协变量纳入多变量回归分析,以确定与使用相关的特征,然后特别是与LARC使用和灭菌相关的特征。结果:2015-2017年共调查424名女性,平均年龄23岁,使用或计划使用产后避孕药具的患病率为87.5%。与初产妇女相比,胎次为2 - 3次的妇女使用任何形式的产后节育的可能性要高10% (RR 1.1, CI[1.01, 1.2])。已婚妇女也更倾向于使用产后方法(RR >10, CI[>10,>10])。LARC使用的患病率很低(4.0%),如果她们被采用,女性更有可能选择这种方法(RR 3.5 CI[1.1, 11.3])。关于绝育,胎次大于1的妇女与初产妇女相比,绝育的可能性增加(RR 3.6 CI [2.5,4.9]);年龄较大的妇女每年产后绝育的可能性增加10% (RR 1.1 CI[1.01,1.08])。如果由熟练的助产士接生(RR 1.8 CI[1.1,2.9])或剖宫产(RR 2.1 CI[1.4,3.1]),妇女也更有可能选择绝育。结论:在这个队列中,高胎次的已婚妇女更有可能使用产后避孕,而有工作的妇女更有可能使用LARC方法。由熟练助产士剖宫产分娩的较高胎次的老年妇女最有可能寻求绝育。
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引用次数: 0
Twelve-Month outcomes of a Cluster-Randomized Trial of Home-Based Postpartum Contraceptive Delivery in Southwest Trifinio, Guatemala. 危地马拉特里菲尼奥西南部一项基于家庭产后避孕的12个月随机分组试验的结果
Pub Date : 2020-12-23 DOI: 10.21203/rs.3.rs-132684/v1
Margo S. Harrison, S. Bunge-Montes, Claudia Rivera, Andrea Jimenez-Zambrano, Gretchen A. Heinrichs, Antonio Bolaños, E. Asturias, Steven Berman, J. Sheeder
DesignWe executed a cluster-randomized parallel arm pragmatic trial to observe the association of home-based postpartum contraceptive provision, including the contraceptive implant, with three and 12-month contraceptive utilization, satisfaction, and pregnancy rates.MethodsEight clusters were randomized to receive either the home-based contraceptive delivery (condoms, pills, injection, implant) during the routine 40-day postpartum visit in addition to routine care, or routine care alone, which included comprehensive contraceptive counseling throughout antepartum care.Results208 women were enrolled in the study, 108 in the intervention clusters and 100 in control clusters. 94 (87.0%) women in the intervention group and 91 (91%) of women in control clusters were evaluated 12 months post-enrollment. Likelihood of using contraception at that time was borderline increased in intervention clusters (RR 1.1 [1.0,1.3], p = 0.05) with an increased likelihood of long-acting contraceptive use (the implant; RR 1.6 [1.3,1.9], p < 0.001). Pregnancy rates were also borderline reduced in the intervention clusters (RR 1.0 [1.0,1.1], p = 0.07). There was no difference in satisfaction of women with contraceptive use between arms with about 95% of women very satisfied or a little satisfied in each arm. Continuation rates at twelve months of contraceptives in the intervention group were 0.0% for condom users, 80.0% for contraceptive pill users, 57% for injectable users, and 83% for implant users. Most women who discontinued their initial method chose a more long-term or permanent method. There was a trend toward a significant association with reduced short interval pregnancy.ConclusionOur study had a borderline increase in overall use of contraception by 12 months, did have an increased likelihood of long-acting contraceptive use of the implant by 12 months, and resulted in a trend toward reduced short interval pregnancy in the intervention clusters as compared to control clusters.
设计我们进行了一项集群随机平行臂实用试验,观察家庭产后避孕(包括避孕植入物)与三个月和十二个月避孕使用率、满意度和妊娠率的关系。方法将8组患者随机分组,在产后40天的常规访视期间,除了常规护理外,还接受家庭避孕分娩(避孕套、药丸、注射、植入),或单独接受常规护理,包括在整个产前护理过程中进行全面的避孕咨询。结果208名女性被纳入研究,108名被纳入干预组,100名被纳入对照组。干预组94名(87.0%)女性和对照组91名(91%)女性在入组12个月后接受了评估。在干预组中,当时使用避孕药具的可能性处于临界增加状态(RR 1.1[1.0,1.3],p=0.05),长效避孕药具使用的可能性增加(植入物;RR 1.6[1.3,1.9],p=0.001)。干预组中的妊娠率也处于临界降低状态(RR 1.0[1.0,1.1],p=0.07)手臂之间的避孕使用,约95%的女性对每只手臂都非常满意或有点满意。在干预组中,避孕套使用者在12个月时避孕药具的继续使用率为0.0%,避孕药使用者为80.0%,注射使用者为57%,植入物使用者为83%。大多数放弃最初方法的女性选择了更长期或永久的方法。有一种趋势是与短间隔妊娠减少有显著关联。结论与对照组相比,我们的研究在12个月前总体避孕使用量增加了一个临界值,在12个月中植入物长效避孕使用的可能性确实增加了,并导致干预组中短间隔妊娠减少的趋势。
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引用次数: 0
Determinants of Behavioral Risk Factors of Hypertensive Disorders in Pregnancy 妊娠期高血压疾病行为危险因素的决定因素
Pub Date : 2020-01-01 DOI: 10.26502/ogr040
Nkem Ernest Njukang, Tah Aldof Yoah, M. Sama, T. Egbe, J. Kamgno
Background: Hypertensive disorders in pregnancy (HDP) remain a major public health problem worldwide, and its prevalence varies from country to country and from institution to institutions. Few studies have explored the behavioral risk factors of hypertension (HTN) among pregnant women in Cameroon. Thus, this study aimed at determining the prevalence and socio-demographic predictors of behavioral risk factors of HDP in Mezam division. Methods: A Hospital-based cross-sectional study was conducted in Mezam division. Over 1210 pregnant women were sampled by consecutive sampling. Descriptive statistics, chi-square (χ2) test and multivariate logistic regression were used for analysis. Results: There was poor uptake of behavioural risk factors: alcohol (21.6%), physical inactivity (49.2%), low fruits/vegetables intake (80.7%), high salt intake (12.4%), stress (48.8%) and overweight/obese (65.5%). Sociodemographic predictors: Age was a risk factor for smoking [Adjusted Odd Ratio (AOR), 95%Confidence interval (CI); (25-29 years): 1.6 (1.1-2.4) & (≥35 years): 2.3 (1.4-3.6)], alcohol [(25-29 years): 1.5 (1.1-2.2) & (≥35 years): 2.5 (1.5-4.1)] and over weight/obesity [(25-29 years): 1.6 (1.2-2.2), (30-34 years): 2.6 (1.8-3.9) & (≥35 years): 2.5 (1.5-4.1)]. Education [secondary school: 1.8 (1.3-2.6) & high school: 2.4 (1.6-3.6)] and Occupation [petit traders: 1.8 (1.4-2.8) & business/employed: 1.9 (1.3-2.9)] were predictors of stress. Religion [Pentecostal: 1.8 (1.1-3.1)] was predictor for high salt consumption. Conclusion: There was poor uptake of behavioural risk factors of HDP. Age, education, occupation and Religion were predictors of behavioural factors of HTN. There is need for immediate health promotion interventions such as raising community awareness and appropriate antenatal counseling.
背景:妊娠期高血压疾病(HDP)仍然是世界范围内的一个主要公共卫生问题,其患病率因国家和机构而异。很少有研究探讨喀麦隆孕妇高血压(HTN)的行为危险因素。因此,本研究旨在确定Mezam地区HDP的患病率和行为危险因素的社会人口学预测因素。方法:在Mezam区进行了一项以医院为基础的横断面研究。连续抽样1210余名孕妇。采用描述性统计、χ2检验和多因素logistic回归进行分析。结果:不良行为风险因素:酒精(21.6%)、缺乏运动(49.2%)、水果/蔬菜摄入量低(80.7%)、盐摄入量高(12.4%)、压力(48.8%)和超重/肥胖(65.5%)。社会人口学预测因素:年龄是吸烟的危险因素[调整奇数比(AOR), 95%可信区间(CI);(25 - 29岁):1.6(1.1 - -2.4)&(≥35年):2.3(1.4 - -3.6)],酒精((25 - 29岁):1.5(1.1 - -2.2)&(≥35年):2.5(1.5 - -4.1)]和超重/肥胖((25 - 29岁):1.6(1.2 - -2.2)(34岁):2.6(1.8 - -3.9)&(≥35年):2.5(1.5 - -4.1)]。教育程度[中学:1.8(1.3-2.6)和高中:2.4(1.6-3.6)]和职业[小商贩:1.8(1.4-2.8)和商业/就业:1.9(1.3-2.9)]是压力的预测因素。宗教[五旬节派:1.8(1.1-3.1)]是高盐摄入的预测因子。结论:HDP的行为危险因素摄取不良。年龄、受教育程度、职业和宗教是影响HTN行为因素的预测因子。需要立即采取促进健康的干预措施,如提高社区认识和适当的产前咨询。
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引用次数: 0
期刊
Obstetrics and gynecology research
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