W. Ho, Chien-Kuan Lee, Chi-Feng Su, Horng‐Jyh Tsai
{"title":"Double Synchronous Primary Gynecologic Carcinoma of the Endometrium and Both Ovaries: A Rare Encounter","authors":"W. Ho, Chien-Kuan Lee, Chi-Feng Su, Horng‐Jyh Tsai","doi":"10.26502/ogr028","DOIUrl":"https://doi.org/10.26502/ogr028","url":null,"abstract":"","PeriodicalId":74336,"journal":{"name":"Obstetrics and gynecology research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69352273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Rigorous peer-review is the main part in building the corner-stone of high-quality academic publishing. The editorial team greatly appreciates the authors, reviewers who contributed their knowledge and expertise to the journal’s editorial process over the past 12 months. In 2018, a total of 15 articles was published in the journal with a median time to first decision of 10 days and a median time to publication of 15 days. The editorial office would like to express their sincere gratitude to the following authors, reviewers and editors for their cooperation and dedication in 2018:
{"title":"Acknowledgement to Authors, Reviewers and Editors of Obstetrics and Gynecology Research in 2018.","authors":"Editorial Office","doi":"10.26502/ogr016","DOIUrl":"https://doi.org/10.26502/ogr016","url":null,"abstract":"Rigorous peer-review is the main part in building the corner-stone of high-quality academic publishing. The editorial team greatly appreciates the authors, reviewers who contributed their knowledge and expertise to the journal’s editorial process over the past 12 months. In 2018, a total of 15 articles was published in the journal with a median time to first decision of 10 days and a median time to publication of 15 days. The editorial office would like to express their sincere gratitude to the following authors, reviewers and editors for their cooperation and dedication in 2018:","PeriodicalId":74336,"journal":{"name":"Obstetrics and gynecology research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69352621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background Althouh there is a great advance in antenatal care, gestational hypertension still one of the major reasons of maternal and neonatal morbidity and mortality. For this reason, early screening of gestational hypertension and fetal growth retardation can permit cautious antenatal monitoring and proper timing of delivery to steer clear of serious complications. Patient and Methods This is a prospective study that included 100 singleton pregnant women with gestational hypertension and complicated with IUGR fetuses who were divided into 2 groups (A and B), each group consists of 50 patients: All patients in group A subjected to fetal Doppler flow indices measurement before corticosteroid administration, and repeated within five days after its administration. Its effect on fetal outcome detected after termination of pregnancy. While women in group B included 50 patients who did not receive corticosteroid therapy. Fetal Doppler flow indices was measured, and after termination of pregnancy effect on fetal outcome was detected as well. Results There was statistically significant difference between the study group after corticosteroid administration and the control group regarding the mean Doppler indices in the form of (MCA PI-RI, UMA PI-RI and CPR). MCA shows higher values in study group after corticosteroid administration than the control group (PI 1.52 ± 0.10 and 1.5 ± 0.18 and RI from 0.78 ± 0.12 to 0.76 ± 0.02. While UMA shows lower values in study group after corticosteroid administration than the control group (PI 1.31 ± 0.16 and 1.36 ± 0.08 and RI 0.72 ± 0.01 and 0.73 ± 0.02. CPR also shows higher values in study group after corticosteroid administration than the control group 1.05 ± 0.05 and 1.04 ± 0.05. Conclusion Corticosteroid administration to hypertensive women is associated with improvement of all Doppler indices in the form of elevation of MCA PI & RI and CPR value and decrease of UMA PI & RI values. Although corticosteroid administration was associated with all these Doppler indices enhancement but there was no associated improvement in the number of fetuses born suffering from tachypnea or admitted to NICU when compared to the other group of women who did not receive corticosteroids. Fetuses who was delivered not affected by tachypnea or not admitted to the NICU shows improvement in UMA PI & RI and CPR in comparison to those who were tachypnic and admitted to the NICU. AEDFV and REDFV signs of UMA are critical signs, usually associated with adverse fetal outcome or fetal compromise.
{"title":"The Effect of Third Trimester Corticosteroid Therapy on Fetal Doppler Velocimetry in Gestational Hypertension Complicated By Intrauterine Growth Restriction","authors":"Hany Maged Abd El Aal, D. Hassan","doi":"10.26502/ogr018","DOIUrl":"https://doi.org/10.26502/ogr018","url":null,"abstract":"Background Althouh there is a great advance in antenatal care, gestational hypertension still one of the major reasons of maternal and neonatal morbidity and mortality. For this reason, early screening of gestational hypertension and fetal growth retardation can permit cautious antenatal monitoring and proper timing of delivery to steer clear of serious complications. Patient and Methods This is a prospective study that included 100 singleton pregnant women with gestational hypertension and complicated with IUGR fetuses who were divided into 2 groups (A and B), each group consists of 50 patients: All patients in group A subjected to fetal Doppler flow indices measurement before corticosteroid administration, and repeated within five days after its administration. Its effect on fetal outcome detected after termination of pregnancy. While women in group B included 50 patients who did not receive corticosteroid therapy. Fetal Doppler flow indices was measured, and after termination of pregnancy effect on fetal outcome was detected as well. Results There was statistically significant difference between the study group after corticosteroid administration and the control group regarding the mean Doppler indices in the form of (MCA PI-RI, UMA PI-RI and CPR). MCA shows higher values in study group after corticosteroid administration than the control group (PI 1.52 ± 0.10 and 1.5 ± 0.18 and RI from 0.78 ± 0.12 to 0.76 ± 0.02. While UMA shows lower values in study group after corticosteroid administration than the control group (PI 1.31 ± 0.16 and 1.36 ± 0.08 and RI 0.72 ± 0.01 and 0.73 ± 0.02. CPR also shows higher values in study group after corticosteroid administration than the control group 1.05 ± 0.05 and 1.04 ± 0.05. Conclusion Corticosteroid administration to hypertensive women is associated with improvement of all Doppler indices in the form of elevation of MCA PI & RI and CPR value and decrease of UMA PI & RI values. Although corticosteroid administration was associated with all these Doppler indices enhancement but there was no associated improvement in the number of fetuses born suffering from tachypnea or admitted to NICU when compared to the other group of women who did not receive corticosteroids. Fetuses who was delivered not affected by tachypnea or not admitted to the NICU shows improvement in UMA PI & RI and CPR in comparison to those who were tachypnic and admitted to the NICU. AEDFV and REDFV signs of UMA are critical signs, usually associated with adverse fetal outcome or fetal compromise.","PeriodicalId":74336,"journal":{"name":"Obstetrics and gynecology research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69352632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Bassowa, Ayoko Ketevi, Palakiyem Panassa, B. Douaguibe, D. Ajavon, K. Fiagnon, S. Aboubakari, K. Akpadza
Objective: To determine the maternal prognosis during macrofen delivery at Sylvanus Olympio CHU. Method and framework: This was a descriptive cross-sectional study that took place in the Obstetrics Gynecology department of the University Hospital Center of Sylvanus Olympio University Hospital in Lome. June 30, 2017 over a period of 5 months. The statistical analysis was done using the software: Microsoft Excel. Results and discussion: Of 3468 deliveries recorded during the study period, 111 resulted in macrosomes, a macrosomia frequency of 3.2%. The highest incidence was observed among parturients in the 26-30 age group at 38.7%. Delivery occurred spontaneously vaginally in 30%, caesarean section in 20%, forceps 1.5%. Maternal complications were: perineal tears (2.2%), delivery hemorrhage (2.2%), cervical tears (0.5%). These complications are more frequent in case of non-prenatal monitoring of pregnant women. Conclusion: Since fetal macrosomia is a real public health problem because of its strong association with infant morbidity and mortality, such a detailed study of children born with excess weight would make it possible to detect the most important factors in order to improve their health. management of this gravido-puerperal pathology in our African environments
{"title":"Maternal Prognosis During Childbirth of 111 Newborns Macrosomes at Chu Sylvanus Olympio","authors":"A. Bassowa, Ayoko Ketevi, Palakiyem Panassa, B. Douaguibe, D. Ajavon, K. Fiagnon, S. Aboubakari, K. Akpadza","doi":"10.26502/ogr019","DOIUrl":"https://doi.org/10.26502/ogr019","url":null,"abstract":"Objective: To determine the maternal prognosis during macrofen delivery at Sylvanus Olympio CHU. Method and framework: This was a descriptive cross-sectional study that took place in the Obstetrics Gynecology department of the University Hospital Center of Sylvanus Olympio University Hospital in Lome. June 30, 2017 over a period of 5 months. The statistical analysis was done using the software: Microsoft Excel. Results and discussion: Of 3468 deliveries recorded during the study period, 111 resulted in macrosomes, a macrosomia frequency of 3.2%. The highest incidence was observed among parturients in the 26-30 age group at 38.7%. Delivery occurred spontaneously vaginally in 30%, caesarean section in 20%, forceps 1.5%. Maternal complications were: perineal tears (2.2%), delivery hemorrhage (2.2%), cervical tears (0.5%). These complications are more frequent in case of non-prenatal monitoring of pregnant women. Conclusion: Since fetal macrosomia is a real public health problem because of its strong association with infant morbidity and mortality, such a detailed study of children born with excess weight would make it possible to detect the most important factors in order to improve their health. management of this gravido-puerperal pathology in our African environments","PeriodicalId":74336,"journal":{"name":"Obstetrics and gynecology research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69352637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Syeda Khadija, S. Gilani, Sabir Butt, M. Yousaf, R. Bacha, Syed Zain ul Hassan Gilani
Objective: To identify the usefulness of Doppler indices in the third trimester for intra-uterine growth- restricted pregnancies. Materials and Methods: It was an observational case-control study of singletons with intra-uterine growth restriction (fetal weight <10th percentile). Intra-uterine growth restricted fetuses (cases) and normal (controls) were examined for the umbilical artery. Time intervals between progressive Doppler abnormalities and configurations of worsening were related to umbilical artery Doppler status and gestational age. This study was conducted from August 2015 to January 2016 at Gilani Ultrasound Center Lahore Pakistan. A total of 60 pregnant females were studied with normal and abnormal umbilical artery Doppler ultrasound. Results: Doppler indices measurements of umbilical artery in intra-uterine growth restriction fetuses in the third trimester showed higher values as compared to normal fetuses. 30 females had normal umbilical artery Doppler indices and waveforms and 30 females showed (either thinning, absent or reversed Diastolic flow Doppler waveform) with higher indices. Conclusion: Fetal umbilical artery Doppler ultrasound is an effective tool in the detection of early intra-uterine growth restriction fetuses.
{"title":"The Efficacy of Doppler Indices in Third Trimester of IUGR Pregnancies","authors":"Syeda Khadija, S. Gilani, Sabir Butt, M. Yousaf, R. Bacha, Syed Zain ul Hassan Gilani","doi":"10.26502/ogr029","DOIUrl":"https://doi.org/10.26502/ogr029","url":null,"abstract":"Objective: To identify the usefulness of Doppler indices in the third trimester for intra-uterine growth- restricted pregnancies. Materials and Methods: It was an observational case-control study of singletons with intra-uterine growth restriction (fetal weight <10th percentile). Intra-uterine growth restricted fetuses (cases) and normal (controls) were examined for the umbilical artery. Time intervals between progressive Doppler abnormalities and configurations of worsening were related to umbilical artery Doppler status and gestational age. This study was conducted from August 2015 to January 2016 at Gilani Ultrasound Center Lahore Pakistan. A total of 60 pregnant females were studied with normal and abnormal umbilical artery Doppler ultrasound. Results: Doppler indices measurements of umbilical artery in intra-uterine growth restriction fetuses in the third trimester showed higher values as compared to normal fetuses. 30 females had normal umbilical artery Doppler indices and waveforms and 30 females showed (either thinning, absent or reversed Diastolic flow Doppler waveform) with higher indices. Conclusion: Fetal umbilical artery Doppler ultrasound is an effective tool in the detection of early intra-uterine growth restriction fetuses.","PeriodicalId":74336,"journal":{"name":"Obstetrics and gynecology research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69352304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Adherence of Obstetrician to the Guideline Regarding the Timing of Elective Caesarean Sections and its Effect on the Neonatal Outcome","authors":"Maysara Mohammed Al-Badran, Maha Saleh Falgoos","doi":"10.26502/ogr021","DOIUrl":"https://doi.org/10.26502/ogr021","url":null,"abstract":"","PeriodicalId":74336,"journal":{"name":"Obstetrics and gynecology research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69352674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aims: We aim to analyze the data from our colposcopy clinic since its transition to the new cervical screening program to determine its effectiveness in clinical practice. Materials and Methods: We extracted data from hospital electronic records, which was analyzed by a bio-statistician. Associations and concordance between referring (Human Papilloma Virus) HPV types, Liquid Based Cytology (LBC), colposcopic impression and cervical biopsy were calculated and analyzed. Results: Data from 262 women who attended our colposcopy clinic from December 2017 to November 2018 was analyzed. Our study showed that the volume of referrals had increased by 6-fold since the implementation of the new cervical screening program in Australia. HPV Other (non 16/18) had the highest prevalence among women referred and accounted for the highest number of high-grade referrals to our unit. Conclusion: 83.3% of referrals with HPV Other (non 16/18) had abnormal cytology. HPV Other appears to be the most pathogenic of all HPV subtypes. The concordance between colposcopic impression and cervical biopsy was 61.9%.
{"title":"Analysis of the Peninsula Health Colposcopy Service Data of One Year Since Transitioning to the New Cervical Screening Program","authors":"Stephanie Sii, A. Trivedi, W. C. Wang","doi":"10.26502/ogr026","DOIUrl":"https://doi.org/10.26502/ogr026","url":null,"abstract":"Aims: We aim to analyze the data from our colposcopy clinic since its transition to the new cervical screening program to determine its effectiveness in clinical practice. Materials and Methods: We extracted data from hospital electronic records, which was analyzed by a bio-statistician. Associations and concordance between referring (Human Papilloma Virus) HPV types, Liquid Based Cytology (LBC), colposcopic impression and cervical biopsy were calculated and analyzed. Results: Data from 262 women who attended our colposcopy clinic from December 2017 to November 2018 was analyzed. Our study showed that the volume of referrals had increased by 6-fold since the implementation of the new cervical screening program in Australia. HPV Other (non 16/18) had the highest prevalence among women referred and accounted for the highest number of high-grade referrals to our unit. Conclusion: 83.3% of referrals with HPV Other (non 16/18) had abnormal cytology. HPV Other appears to be the most pathogenic of all HPV subtypes. The concordance between colposcopic impression and cervical biopsy was 61.9%.","PeriodicalId":74336,"journal":{"name":"Obstetrics and gynecology research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69352259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pramod Kumar, Poonam Varma Shivkumar, M. Barambhe, M. Bathla, J. Lowe, T. Khokhar, Samita Bharadwaj, Vinay Jain
{"title":"E-Partography- A Rural Tertiary Hospital Experience","authors":"Pramod Kumar, Poonam Varma Shivkumar, M. Barambhe, M. Bathla, J. Lowe, T. Khokhar, Samita Bharadwaj, Vinay Jain","doi":"10.26502/ogr024","DOIUrl":"https://doi.org/10.26502/ogr024","url":null,"abstract":"","PeriodicalId":74336,"journal":{"name":"Obstetrics and gynecology research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69352687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Elsirgany, H. Badawi, Z. El-khayat, M. Bibers, M. Hamdy, A. Hamdy, S. Salama, Rehab A. Lotfy, M. Alalfy
Objective: Fetuin-A is a glycoprotein which is present in circulation that might be linked to insulin resistance and polycystic ovary syndrome (PCOS). The aim of our study was to investigate the changes in Fetuin-A levels as a possible marker in patients with PCOS. Methods: In this study we included a total of 80 women. Group A;40 women with PCOS represented this study group, while another 40 women with regular cycles and no symptoms of hyperandrogenemia represented the controls(Group B). Fetuin-A level was measured in both groups to compare the level of this hormone. Results: Our results showed that Fetuin A concentration in the PCOS group was elevated than the control group (mean ± SD: 521 ± 7.1 vs 505 ± 50.5 ng/ml respectively) and the difference was statistically significant. Conclusions: Fetuin A level could be proposed as a screening test for PCOS with a cutoff value of 515 ng/ ml, the sensitivity and specificity were one hundred % and forty five %, respectively.
目的:胎儿素a是一种存在于血液循环中的糖蛋白，可能与胰岛素抵抗和多囊卵巢综合征(PCOS)有关。我们研究的目的是探讨胎儿素a水平的变化作为多囊卵巢综合征患者可能的标志物。方法:本研究共纳入80名女性。A组:40名患有多囊卵巢综合征的女性代表该研究组，而另外40名月经规律且无高雄激素血症症状的女性代表对照组(B组)。测量两组的胎儿激素A水平以比较该激素水平。结果:PCOS组Fetuin A浓度较对照组升高(mean±SD: 521±7.1 vs 505±50.5 ng/ml)，差异有统计学意义。结论:胎儿素A水平可作为PCOS筛查指标，临界值为515 ng/ ml，敏感性为100%，特异性为45%。
{"title":"Serum Fetuin a Level: A New Possible Marker for Polycystic Ovarian Syndrome in Women with Infertility","authors":"S. Elsirgany, H. Badawi, Z. El-khayat, M. Bibers, M. Hamdy, A. Hamdy, S. Salama, Rehab A. Lotfy, M. Alalfy","doi":"10.26502/ogr027","DOIUrl":"https://doi.org/10.26502/ogr027","url":null,"abstract":"Objective: Fetuin-A is a glycoprotein which is present in circulation that might be linked to insulin resistance and polycystic ovary syndrome (PCOS). The aim of our study was to investigate the changes in Fetuin-A levels as a possible marker in patients with PCOS. Methods: In this study we included a total of 80 women. Group A;40 women with PCOS represented this study group, while another 40 women with regular cycles and no symptoms of hyperandrogenemia represented the controls(Group B). Fetuin-A level was measured in both groups to compare the level of this hormone. Results: Our results showed that Fetuin A concentration in the PCOS group was elevated than the control group (mean ± SD: 521 ± 7.1 vs 505 ± 50.5 ng/ml respectively) and the difference was statistically significant. Conclusions: Fetuin A level could be proposed as a screening test for PCOS with a cutoff value of 515 ng/ ml, the sensitivity and specificity were one hundred % and forty five %, respectively.","PeriodicalId":74336,"journal":{"name":"Obstetrics and gynecology research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69352262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Labour pain described as ‘the most horrible’ affects both physiological and psychological aspects of labour. Thus, the provision of labour analgesia is of paramount importance to better both maternal and neonatal outcomes. In our country, majority of obstetric services are in the hands of trained nurses and non-specialized doctors and thus awareness and acceptance of pain-relieving for women in labour virtually does not exist. Therefore, drugs like paracetamol and tramadol with advantage of easy availability, being inexpensive with no special technique of administration are a boon for labour analgesia. Objective: To compare the role of intravenous paracetamol versus intravenous tramadol as an intrapartum labour analgesic. Materials and methods: A total of 273 primigravidae with term gestation with singleton pregnancy with vertex presentation in active phase of labour with cervical dilatation ≥ 4cm with spontaneous onset of labour were taken who satisfied the inclusion and exclusion criteria of the study. Group P (141 women) and Group T (132 women) received 100 ml intravenous infusion containing 1 gram of paracetamol single dose and 100 mg of tramadol hydrochloride diluted in 100 ml normal saline over 15 minutes respectively. Visual Analogue scale (VAS) was used to assess pain intensity, before administering drug, after 1 and 3 hours of drug administration. The primary outcomes measured were difference in VAS score in both groups. The secondary outcomes analysed were mode of delivery, duration of labour, drug-delivery interval, maternal side effects and neonatal outcomes in terms of birth weight, APGAR scores and NICU admissions. Results: The mean VAS score decreased significantly to a greater extent in group P than group T and showed a significant statistical difference among both the groups (p < 0.001). In both the groups, the difference in the VAS score was statistically significant (p<0.05). The duration of labour was statistically shorter in group P (p< 0.0001). The participants in group T had more incidence of maternal side-effects and 7 NICU admission than in paracetamol group. Conclusion: Intravenous paracetamol with better analgesic efficacy, shorter duration of labour and fewer maternal side effects is a more effective labour analgesic than tramadol.
{"title":"A Randomized Controlled Trial of Intravenous Paracetamol and Intravenous Tramadol for Labour Analgesia","authors":"N. Garg, Vanitha Vg","doi":"10.26502/ogr017","DOIUrl":"https://doi.org/10.26502/ogr017","url":null,"abstract":"Background: Labour pain described as ‘the most horrible’ affects both physiological and psychological aspects of labour. Thus, the provision of labour analgesia is of paramount importance to better both maternal and neonatal outcomes. In our country, majority of obstetric services are in the hands of trained nurses and non-specialized doctors and thus awareness and acceptance of pain-relieving for women in labour virtually does not exist. Therefore, drugs like paracetamol and tramadol with advantage of easy availability, being inexpensive with no special technique of administration are a boon for labour analgesia. Objective: To compare the role of intravenous paracetamol versus intravenous tramadol as an intrapartum labour analgesic. Materials and methods: A total of 273 primigravidae with term gestation with singleton pregnancy with vertex presentation in active phase of labour with cervical dilatation ≥ 4cm with spontaneous onset of labour were taken who satisfied the inclusion and exclusion criteria of the study. Group P (141 women) and Group T (132 women) received 100 ml intravenous infusion containing 1 gram of paracetamol single dose and 100 mg of tramadol hydrochloride diluted in 100 ml normal saline over 15 minutes respectively. Visual Analogue scale (VAS) was used to assess pain intensity, before administering drug, after 1 and 3 hours of drug administration. The primary outcomes measured were difference in VAS score in both groups. The secondary outcomes analysed were mode of delivery, duration of labour, drug-delivery interval, maternal side effects and neonatal outcomes in terms of birth weight, APGAR scores and NICU admissions. Results: The mean VAS score decreased significantly to a greater extent in group P than group T and showed a significant statistical difference among both the groups (p < 0.001). In both the groups, the difference in the VAS score was statistically significant (p<0.05). The duration of labour was statistically shorter in group P (p< 0.0001). The participants in group T had more incidence of maternal side-effects and 7 NICU admission than in paracetamol group. Conclusion: Intravenous paracetamol with better analgesic efficacy, shorter duration of labour and fewer maternal side effects is a more effective labour analgesic than tramadol.","PeriodicalId":74336,"journal":{"name":"Obstetrics and gynecology research","volume":"57 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69352626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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