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Vaping: Public Health, Social Media, and Toxicity. 吸烟:公共卫生、社交媒体和毒性。
Pub Date : 2024-04-11 DOI: 10.2196/53245
Yehao Sun, Prital Prabhu, Dongmei Li, Scott McIntosh, Irfan Rahman
This viewpoint aims to provide a comprehensive understanding of vaping from various perspectives that contribute to the invention, development, spread, and consequences of e-cigarette products and vaping. Our analysis showed that the specific characteristics of e-cigarette products as well as marketing strategies, especially social media marketing, fostered the spread of vaping and the subsequent effects on human health and toxicity. We analyzed the components of e-cigarette devices and e-liquids, including the latest variants whose impacts were often overlooked. The different forms of nicotine, including salts and freebase nicotine, tobacco-derived nicotine, tobacco-free nicotine, and cooling agents (WS3 and WS23), have brought more choices for vapers along with more ways for e-cigarette manufacturers to advertise false understandings and present a greater threat to vapers' health. Our work emphasized the products of brands that have gained significant influence recently, which are contributing to severe public health issues. On the other hand, we also discussed in detail the toxicity of e-liquid components and proposed a toxicity mechanism. We also noticed that nicotine and other chemicals in e-liquids promote each other's negative effects through the oxidative stress and inflammatory nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) pathway, a mechanism leading to pulmonary symptoms and addiction. The impact of government regulations on the products themselves, including flavor bans or regulations, has been limited. Therefore, we proposed further interventions or harm reduction strategies from a public health perspective.
这一观点旨在从有助于电子烟产品和吸食电子烟的发明、发展、传播和后果的各个角度全面了解吸食电子烟。我们的分析表明,电子烟产品的具体特征以及营销策略,尤其是社交媒体营销,促进了吸食电子烟的传播以及随后对人类健康和毒性的影响。我们分析了电子烟设备和电子烟液的成分,包括其影响往往被忽视的最新变体。不同形式的尼古丁,包括盐类和游离基尼古丁、烟草衍生尼古丁、无烟尼古丁和冷却剂(WS3 和 WS23),为吸烟者带来了更多选择,同时也使电子烟制造商有更多途径进行虚假宣传,对吸烟者的健康造成更大威胁。我们的工作强调了近期具有重大影响力的品牌产品,这些产品正在造成严重的公共健康问题。另一方面,我们还详细讨论了电子液体成分的毒性,并提出了毒性机制。我们还注意到,电子烟中的尼古丁和其他化学物质会通过氧化应激和炎症性核因子卡帕-轻链-活化B细胞增强因子(NF-κB)途径相互促进负面影响,这一机制会导致肺部症状和成瘾。政府法规对产品本身的影响有限,包括香精禁令或法规。因此,我们从公共卫生的角度提出了进一步的干预措施或减少危害的策略。
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引用次数: 0
Correction: Machine Learning Model for Predicting Mortality Risk in Patients With Complex Chronic Conditions: Retrospective Analysis. 更正:预测复杂慢性病患者死亡风险的机器学习模型:回顾性分析
Pub Date : 2024-03-21 DOI: 10.2196/58453
Guillem Hernández Guillamet, Ariadna Ning Morancho Pallaruelo, Laura Miró Mezquita, Ramón Miralles, Miquel Àngel Mas, María José Ulldemolins Papaseit, Oriol Estrada Cuxart, Francesc López Seguí

[This corrects the article DOI: 10.2196/52782.].

[此处更正了文章 DOI:10.2196/52782]。
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引用次数: 0
Roles of Health Literacy in Relation to Social Determinants of Health and Recommendations for Informatics-Based Interventions: Systematic Review. 健康素养在健康的社会决定因素中的作用以及基于信息学的干预建议:系统回顾。
Pub Date : 2024-03-20 DOI: 10.2196/50898
Shwetha Bindhu, Anunita Nattam, Catherine Xu, Tripura Vithala, Tiffany Grant, Jacinda K Dariotis, Hexuan Liu, Danny T Y Wu

Background: Health literacy (HL) is the ability to make informed decisions using health information. As health data and information availability increase due to online clinic notes and patient portals, it is important to understand how HL relates to social determinants of health (SDoH) and the place of informatics in mitigating disparities.

Objective: This systematic literature review aims to examine the role of HL in interactions with SDoH and to identify feasible HL-based interventions that address low patient understanding of health information to improve clinic note-sharing efficacy.

Methods: The review examined 2 databases, Scopus and PubMed, for English-language articles relating to HL and SDoH. We conducted a quantitative analysis of study characteristics and qualitative synthesis to determine the roles of HL and interventions.

Results: The results (n=43) were analyzed quantitatively and qualitatively for study characteristics, the role of HL, and interventions. Most articles (n=23) noted that HL was a result of SDoH, but other articles noted that it could also be a mediator for SdoH (n=6) or a modifiable SdoH (n=14) itself.

Conclusions: The multivariable nature of HL indicates that it could form the basis for many interventions to combat low patient understandability, including 4 interventions using informatics-based solutions. HL is a crucial, multidimensional skill in supporting patient understanding of health materials. Designing interventions aimed at improving HL or addressing poor HL in patients can help increase comprehension of health information, including the information contained in clinic notes shared with patients.

背景:健康素养(HL)是指利用健康信息做出明智决策的能力。随着在线门诊笔记和患者门户网站带来的健康数据和信息可用性的增加,了解健康素养与健康的社会决定因素(SDoH)之间的关系以及信息学在缩小差距方面的作用非常重要:本系统性文献综述旨在研究健康知识在与 SDoH 相互作用中的作用,并确定可行的基于健康知识的干预措施,以解决患者对健康信息理解不足的问题,从而提高诊所笔记共享的效率:本综述在 Scopus 和 PubMed 两个数据库中检索了与 HL 和 SDoH 相关的英文文章。我们对研究特点进行了定量分析,并进行了定性综合,以确定 HL 和干预措施的作用:我们对研究结果(n=43)的研究特点、HL 的作用和干预措施进行了定量和定性分析。大多数文章(n=23)指出HL是SDoH的结果,但其他文章指出HL也可能是SdoH的中介(n=6)或可改变的SdoH(n=14):HL的多变量性质表明,它可以成为许多干预措施的基础,以解决患者理解能力低的问题,其中包括使用基于信息学解决方案的4项干预措施。HL是支持患者理解健康材料的一项重要的多维技能。设计旨在提高患者可理解性的干预措施或解决患者可理解性差的问题,有助于提高患者对健康信息的理解,包括与患者共享的诊疗记录中所包含的信息。
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引用次数: 0
Electronic Health Records for Population Health Management: Comparison of Electronic Health Record-Derived Hypertension Prevalence Measures Against Established Survey Data. 用于人口健康管理的电子健康记录:将电子健康记录得出的高血压患病率指标与已有的调查数据进行比较。
Pub Date : 2024-03-13 DOI: 10.2196/48300
Katie S Allen, Nimish Valvi, P Joseph Gibson, Timothy McFarlane, Brian E Dixon

Background: Hypertension is the most prevalent risk factor for mortality globally. Uncontrolled hypertension is associated with excess morbidity and mortality, and nearly one-half of individuals with hypertension do not have the condition under control. Data from electronic health record (EHR) systems may be useful for community hypertension surveillance, filling a gap in local public health departments' community health assessments and supporting the public health data modernization initiatives currently underway. To identify patients with hypertension, computable phenotypes are required. These phenotypes leverage available data elements-such as vitals measurements and medications-to identify patients diagnosed with hypertension. However, there are multiple methodologies for creating a phenotype, and the identification of which method most accurately reflects real-world prevalence rates is needed to support data modernization initiatives.

Objective: This study sought to assess the comparability of 6 different EHR-based hypertension prevalence estimates with estimates from a national survey. Each of the prevalence estimates was created using a different computable phenotype. The overarching goal is to identify which phenotypes most closely align with nationally accepted estimations.

Methods: Using the 6 different EHR-based computable phenotypes, we calculated hypertension prevalence estimates for Marion County, Indiana, for the period from 2014 to 2015. We extracted hypertension rates from the Behavioral Risk Factor Surveillance System (BRFSS) for the same period. We used the two 1-sided t test (TOST) to test equivalence between BRFSS- and EHR-based prevalence estimates. The TOST was performed at the overall level as well as stratified by age, gender, and race.

Results: Using both 80% and 90% CIs, the TOST analysis resulted in 2 computable phenotypes demonstrating rough equivalence to BRFSS estimates. Variation in performance was noted across phenotypes as well as demographics. TOST with 80% CIs demonstrated that the phenotypes had less variance compared to BRFSS estimates within subpopulations, particularly those related to racial categories. Overall, less variance occurred on phenotypes that included vitals measurements.

Conclusions: This study demonstrates that certain EHR-derived prevalence estimates may serve as rough substitutes for population-based survey estimates. These outcomes demonstrate the importance of critically assessing which data elements to include in EHR-based computer phenotypes. Using comprehensive data sources, containing complete clinical data as well as data representative of the population, are crucial to producing robust estimates of chronic disease. As public health departments look toward data modernization activities, the EHR may serve to assist in more timely, locally representative estimates for chronic

背景:高血压是全球最普遍的死亡风险因素。未得到控制的高血压与高发病率和高死亡率有关,近二分之一的高血压患者病情未得到控制。来自电子健康记录(EHR)系统的数据可用于社区高血压监测,填补地方公共卫生部门社区健康评估的空白,并支持目前正在进行的公共卫生数据现代化计划。要识别高血压患者,需要可计算的表型。这些表型利用现有的数据元素(如生命体征测量和药物治疗)来识别被诊断为高血压的患者。然而,创建表型有多种方法,需要确定哪种方法能最准确地反映真实世界的患病率,以支持数据现代化计划:本研究旨在评估 6 种不同的基于电子病历的高血压患病率估计值与一项全国性调查的估计值之间的可比性。每种患病率估计值均采用不同的可计算表型。总体目标是确定哪些表型与全国公认的估计值最为接近:使用 6 种不同的基于电子病历的可计算表型,我们计算了印第安纳州马里恩县 2014 年至 2015 年期间的高血压患病率估计值。我们从行为风险因素监测系统(BRFSS)中提取了同期的高血压发病率。我们使用两个单侧 t 检验(TOST)来检验基于 BRFSS 和基于电子病历的患病率估计值之间的等效性。TOST 在总体水平上进行,并按年龄、性别和种族进行分层:结果:使用 80% 和 90% CIs,TOST 分析得出了两个可计算的表型,与 BRFSS 估计值大致相当。不同表型和不同人口统计学特征的表现存在差异。具有 80% CIs 的 TOST 表明,与 BRFSS 估计值相比,表型在亚人群中的差异较小,尤其是与种族类别相关的表型。总体而言,包括生命体征测量在内的表型差异较小:本研究表明,某些由电子病历得出的患病率估计值可粗略替代基于人群的调查估计值。这些结果表明,必须严格评估在基于电子病历的计算机表型中包含哪些数据元素。使用包含完整临床数据和人口代表性数据的综合数据源,对于得出可靠的慢性病估计值至关重要。随着公共卫生部门着眼于数据现代化活动,电子病历可能有助于更及时地估算出具有地方代表性的慢性病患病率。
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引用次数: 0
A Semantic Approach to Describe Social and Economic Characteristics That Impact Health Outcomes (Social Determinants of Health): Ontology Development Study. 描述影响健康结果的社会和经济特征(健康的社会决定因素)的语义方法:本体开发研究。
Pub Date : 2024-03-13 DOI: 10.2196/52845
Daniela Dally, Muhammad Amith, Rebecca L Mauldin, Latisha Thomas, Yifang Dang, Cui Tao

Background: Social determinants of health (SDoH) have been described by the World Health Organization as the conditions in which individuals are born, live, work, and age. These conditions can be grouped into 3 interrelated levels known as macrolevel (societal), mesolevel (community), and microlevel (individual) determinants. The scope of SDoH expands beyond the biomedical level, and there remains a need to connect other areas such as economics, public policy, and social factors.

Objective: Providing a computable artifact that can link health data to concepts involving the different levels of determinants may improve our understanding of the impact SDoH have on human populations. Modeling SDoH may help to reduce existing gaps in the literature through explicit links between the determinants and biological factors. This in turn can allow researchers and clinicians to make better sense of data and discover new knowledge through the use of semantic links.

Methods: An experimental ontology was developed to represent knowledge of the social and economic characteristics of SDoH. Information from 27 literature sources was analyzed to gather concepts and encoded using Web Ontology Language, version 2 (OWL2) and Protégé. Four evaluators independently reviewed the ontology axioms using natural language translation. The analyses from the evaluations and selected terminologies from the Basic Formal Ontology were used to create a revised ontology with a broad spectrum of knowledge concepts ranging from the macrolevel to the microlevel determinants.

Results: The literature search identified several topics of discussion for each determinant level. Publications for the macrolevel determinants centered around health policy, income inequality, welfare, and the environment. Articles relating to the mesolevel determinants discussed work, work conditions, psychosocial factors, socioeconomic position, outcomes, food, poverty, housing, and crime. Finally, sources found for the microlevel determinants examined gender, ethnicity, race, and behavior. Concepts were gathered from the literature and used to produce an ontology consisting of 383 classes, 109 object properties, and 748 logical axioms. A reasoning test revealed no inconsistent axioms.

Conclusions: This ontology models heterogeneous social and economic concepts to represent aspects of SDoH. The scope of SDoH is expansive, and although the ontology is broad, it is still in its early stages. To our current understanding, this ontology represents the first attempt to concentrate on knowledge concepts that are currently not covered by existing ontologies. Future direction will include further expanding the ontology to link with other biomedical ontologies, including alignment for granular semantics.

背景:世界卫生组织将健康的社会决定因素(SDoH)描述为个人出生、生活、工作和衰老的条件。这些条件可分为三个相互关联的层面,即宏观层面(社会)、中观层面(社区)和微观层面(个人)的决定因素。SDoH 的范围超出了生物医学层面,仍然需要将经济、公共政策和社会因素等其他领域联系起来:提供一种可计算的工具,将健康数据与涉及不同层面决定因素的概念联系起来,可以提高我们对 SDoH 对人群影响的理解。通过将决定因素与生物因素明确联系起来,建立 SDoH 模型可有助于缩小文献中的现有差距。这反过来又能让研究人员和临床医生更好地理解数据,并通过使用语义链接发现新知识:方法:开发了一个实验性本体论,用于表示有关 SDoH 的社会和经济特征的知识。我们分析了 27 篇文献来源的信息以收集概念,并使用网络本体语言第 2 版(OWL2)和 Protégé 进行编码。四名评估员使用自然语言翻译对本体公理进行了独立审查。评估分析结果和从基本形式本体中选取的术语被用于创建一个经过修订的本体,其中包含从宏观层面到微观层面决定因素的广泛知识概念:文献检索为每个决定因素层次确定了几个讨论主题。有关宏观决定因素的文献主要集中在卫生政策、收入不平等、福利和环境方面。与中观决定因素有关的文章讨论了工作、工作条件、社会心理因素、社会经济地位、结果、食品、贫困、住房和犯罪。最后,微观决定因素的资料来源包括性别、民族、种族和行为。从文献中收集的概念被用于创建本体论,本体论由 383 个类、109 个对象属性和 748 个逻辑公理组成。推理测试表明没有不一致的公理:本体对不同的社会和经济概念进行了建模,以表示 SDoH 的各个方面。SDoH 的范围很广,虽然本体很宽泛,但仍处于早期阶段。就我们目前的理解而言,本体论代表了对现有本体论未涵盖的知识概念的首次集中尝试。未来的发展方向将包括进一步扩展本体,与其他生物医学本体建立联系,包括细粒度语义的对齐。
{"title":"A Semantic Approach to Describe Social and Economic Characteristics That Impact Health Outcomes (Social Determinants of Health): Ontology Development Study.","authors":"Daniela Dally, Muhammad Amith, Rebecca L Mauldin, Latisha Thomas, Yifang Dang, Cui Tao","doi":"10.2196/52845","DOIUrl":"10.2196/52845","url":null,"abstract":"<p><strong>Background: </strong>Social determinants of health (SDoH) have been described by the World Health Organization as the conditions in which individuals are born, live, work, and age. These conditions can be grouped into 3 interrelated levels known as macrolevel (societal), mesolevel (community), and microlevel (individual) determinants. The scope of SDoH expands beyond the biomedical level, and there remains a need to connect other areas such as economics, public policy, and social factors.</p><p><strong>Objective: </strong>Providing a computable artifact that can link health data to concepts involving the different levels of determinants may improve our understanding of the impact SDoH have on human populations. Modeling SDoH may help to reduce existing gaps in the literature through explicit links between the determinants and biological factors. This in turn can allow researchers and clinicians to make better sense of data and discover new knowledge through the use of semantic links.</p><p><strong>Methods: </strong>An experimental ontology was developed to represent knowledge of the social and economic characteristics of SDoH. Information from 27 literature sources was analyzed to gather concepts and encoded using Web Ontology Language, version 2 (OWL2) and Protégé. Four evaluators independently reviewed the ontology axioms using natural language translation. The analyses from the evaluations and selected terminologies from the Basic Formal Ontology were used to create a revised ontology with a broad spectrum of knowledge concepts ranging from the macrolevel to the microlevel determinants.</p><p><strong>Results: </strong>The literature search identified several topics of discussion for each determinant level. Publications for the macrolevel determinants centered around health policy, income inequality, welfare, and the environment. Articles relating to the mesolevel determinants discussed work, work conditions, psychosocial factors, socioeconomic position, outcomes, food, poverty, housing, and crime. Finally, sources found for the microlevel determinants examined gender, ethnicity, race, and behavior. Concepts were gathered from the literature and used to produce an ontology consisting of 383 classes, 109 object properties, and 748 logical axioms. A reasoning test revealed no inconsistent axioms.</p><p><strong>Conclusions: </strong>This ontology models heterogeneous social and economic concepts to represent aspects of SDoH. The scope of SDoH is expansive, and although the ontology is broad, it is still in its early stages. To our current understanding, this ontology represents the first attempt to concentrate on knowledge concepts that are currently not covered by existing ontologies. Future direction will include further expanding the ontology to link with other biomedical ontologies, including alignment for granular semantics.</p>","PeriodicalId":74345,"journal":{"name":"Online journal of public health informatics","volume":"16 ","pages":"e52845"},"PeriodicalIF":0.0,"publicationDate":"2024-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10973958/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140112354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Health Information Seeking Behavior on Social Networking Sites and Self-Treatment: Pilot Survey Study. 在社交网站上寻求健康信息的行为与自我治疗:试点调查研究。
Pub Date : 2023-12-20 eCollection Date: 2023-01-01 DOI: 10.2196/51984
Reginald A Silver, Chandrika Johnson

Background: Social networking site use and social network-based health information seeking behavior have proliferated to the point that the lines between seeking health information from credible social network-based sources and the decision to seek medical care or attempt to treat oneself have become blurred.

Objective: We contribute to emerging research on health information seeking behavior by investigating demographic factors, social media use for health information seeking purposes, and the relationship between health information seeking and occurrences of self-treatment.

Methods: Data were collected from an online survey in which participants were asked to describe sociodemographic factors about themselves, social media use patterns, perceptions about their motivations for health information seeking on social media platforms, and whether or not they attempted self-treatment after their social media-related health information seeking. We conducted a binomial logistic regression with self-treatment as a dichotomous categorical dependent variable.

Results: Results indicate that significant predictors of self-treatment based on information obtained from social networking sites include race, exercise frequency, and degree of trust in the health-related information received.

Conclusions: With an understanding of how sociodemographic factors might influence the decision to self-treat based on information obtained from social networking sites, health care providers can assist patients by educating them on credible social network-based sources of health information and discussing the importance of seeking medical advice from a health care provider.

背景:社交网站的使用和基于社交网络的健康信息寻求行为已经激增,以至于从可靠的社交网络来源寻求健康信息与决定就医或尝试自我治疗之间的界限变得模糊不清:我们通过调查人口统计学因素、为寻求健康信息而使用社交媒体的情况以及寻求健康信息与自我治疗之间的关系,为有关健康信息寻求行为的新兴研究做出贡献:通过在线调查收集数据,要求参与者描述自己的社会人口学因素、社交媒体使用模式、对在社交媒体平台上寻求健康信息的动机的看法,以及在寻求与社交媒体相关的健康信息后是否尝试过自我治疗。我们以自我治疗为二分类因变量进行了二项逻辑回归:结果表明,基于从社交网站上获得的信息进行自我治疗的重要预测因素包括种族、运动频率以及对所获健康相关信息的信任程度:在了解了社会人口因素如何影响患者根据从社交网站获得的信息进行自我治疗的决定后,医疗服务提供者可以帮助患者,向他们介绍可靠的社交网络健康信息来源,并讨论向医疗服务提供者寻求医疗建议的重要性。
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引用次数: 0
Intersection of Perceived COVID-19 Risk, Preparedness, and Preventive Health Behaviors: Latent Class Segmentation Analysis 感知COVID-19风险、准备和预防性健康行为的交集:潜在类别分割分析
Pub Date : 2023-10-24 DOI: 10.2196/50967
Osaro Mgbere, Sorochi Iloanusi, Ismaeel Yunusa, Nchebe-Jah R Iloanusi, Shrey Gohil, Ekere James Essien
Background COVID-19 risk perception is a factor that influences the pandemic spread. Understanding the potential behavioral responses to COVID-19, including preparedness and adoption of preventive measures, can inform interventions to curtail its spread. Objective We assessed self-perceived and latent class analysis (LCA)–based risks of COVID-19 and their associations with preparedness, misconception, information gap, and preventive practices among residents of a densely populated city in Nigeria. Methods We used data from a cross-sectional survey conducted among residents (N=140) of Onitsha, Nigeria, in March 2020, before the government-mandated lockdown. Using an iterative expectation-maximization algorithm, we applied LCA to systematically segment participants into the most likely distinct risk clusters. Furthermore, we used bivariate and multivariable logistic regression models to determine the associations among knowledge, attitude, preventive practice, perceived preparedness, misconception, COVID-19 information gap, and self-perceived and LCA-based COVID-19 risks. Results Most participants (85/140, 60.7%) had good knowledge and did not perceive themselves as at risk of contracting COVID-19. Three-quarters of the participants (102/137, 74.6%; P<.001) experienced COVID-19–related information gaps, while 62.9% (88/140; P=.04) of the participants had some misconceptions about the disease. Conversely, most participants (93/140, 66.4%; P<.001) indicated that they were prepared for the COVID-19 pandemic. The majority of the participants (94/138, 68.1%; P<.001) self-perceived that they were not at risk of contracting COVID-19 compared to 31.9% (44/138) who professed to be at risk of contracting COVID-19. Using the LCA, we identified 3 distinct risk clusters (P<.001), namely, prudent or low-risk takers, skeptics or high-risk takers, and carefree or very high-risk takers with prevalence rates (probabilities of cluster membership that represent the prevalence rate [γc]) of 47.5% (95% CI 40%-55%), 16.2% (95% CI 11.4%-20.9%), and 36.4% (95% CI 28.8%-43.9%), respectively. We recorded a significantly negative agreement between self-perceived risk and LCA-based segmentation of COVID-19 risk (κ=–0.218, SD 0.067; P=.01). Knowledge, attitude, and perceived need for COVID-19 information were significant predictors of COVID-19 preventive practices among the Onitsha city residents. Conclusions The clustering patterns highlight the impact of modifiable risk behaviors on COVID-19 preventive practices, which can provide strong empirical support for health prevention policies. Consequently, clusters with individuals at high risk of contracting COVID-19 would benefit from multicomponent interventions delivered in diverse settings to improve the population-based response to the pandemic.
背景COVID-19风险认知是影响大流行传播的一个因素。了解对COVID-19的潜在行为反应,包括准备和采取预防措施,可以为采取干预措施提供信息,以遏制其传播。目的评估尼日利亚某人口稠密城市居民中基于自我感知和潜在类别分析(LCA)的COVID-19风险及其与防范、误解、信息缺口和预防措施的关系。方法我们使用了2020年3月在政府强制封锁之前对尼日利亚奥尼沙居民(N=140)进行的横断面调查的数据。使用迭代期望最大化算法,我们应用LCA系统地将参与者划分为最可能不同的风险集群。此外,我们使用双变量和多变量逻辑回归模型来确定知识、态度、预防实践、感知准备、误解、COVID-19信息差距以及自我感知和基于lca的COVID-19风险之间的关系。结果大多数参与者(85/140,60.7%)对COVID-19有良好的了解,并且没有意识到自己有感染COVID-19的风险。四分之三的参与者(102/137,74.6%;P<.001)经历了与covid -19相关的信息空白,而62.9% (88/140;P=.04)。相反,大多数参与者(93/140,66.4%;P<.001)表明他们为COVID-19大流行做好了准备。大多数参与者(94/138,68.1%;P<.001)自我认为他们没有感染COVID-19的风险,而声称有感染COVID-19风险的人为31.9%(44/138)。使用LCA,我们确定了3个不同的风险集群(P<.001),即谨慎或低风险的承担者,怀疑论者或高风险的承担者,无忧无虑或非常高风险的承担者,患病率(代表患病率的集群成员概率[γc])分别为47.5% (95% CI 40%-55%), 16.2% (95% CI 11.4%-20.9%)和36.4% (95% CI 28.8%-43.9%)。我们记录了自我感知风险与基于lca的COVID-19风险分割之间的显著负相关(κ= -0.218, SD 0.067;P = . 01)。知识、态度和对COVID-19信息的感知需求是奥尼察市居民COVID-19预防措施的重要预测因素。结论聚类模式突出了可改变风险行为对COVID-19预防实践的影响,可为卫生预防政策提供有力的实证支持。因此,个体感染COVID-19的高风险聚集性将受益于在不同环境中提供的多成分干预措施,以改善以人群为基础的大流行应对措施。
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引用次数: 0
Toxicology Test Results for Public Health Surveillance of the Opioid Epidemic: Retrospective Analysis 阿片类药物流行的公共卫生监测毒理学试验结果:回顾性分析
Pub Date : 2023-09-28 DOI: 10.2196/50936
Titus Schleyer, Bill Robinson, Samir Parmar, Diane Janowiak, P Joseph Gibson, Val Spangler
Background Addressing the opioid epidemic requires timely insights into population-level factors, such as trends in prevalence of legal and illegal substances, overdoses, and deaths. Objective This study aimed to examine whether toxicology test results of living individuals from a variety of sources could be useful in surveilling the opioid epidemic. Methods A retrospective analysis standardized, merged, and linked toxicology results from 24 laboratories in Marion County, Indiana, United States, from September 1, 2018, to August 31, 2019. The data set consisted of 33,787 Marion County residents and their 746,681 results. We related the data to general Marion County demographics and compared alerts generated by toxicology results to opioid overdose–related emergency department visits. Nineteen domain experts helped prototype analytical visualizations. Main outcome measures included test positivity in the county and by ZIP code; selected demographics of individuals with toxicology results; and correlation of toxicology results with opioid overdose–related emergency department visits. Results Four percent of Marion County residents had at least 1 toxicology result. Test positivity rates ranged from 3% to 19% across ZIP codes. Males were underrepresented in the data set. Age distribution resembled that of Marion County. Alerts for opioid toxicology results were not correlated with opioid overdose–related emergency department visits. Conclusions Analyzing toxicology results at scale was impeded by varying data formats, completeness, and representativeness; changes in data feeds; and patient matching difficulties. In this study, toxicology results did not predict spikes in opioid overdoses. Larger, more rigorous and well-controlled studies are needed to assess the utility of toxicology tests in predicting opioid overdose spikes.
解决阿片类药物流行问题需要及时了解人口层面的因素,如合法和非法药物流行趋势、过量使用和死亡。目的本研究旨在探讨来自各种来源的活体毒理学测试结果是否可用于监测阿片类药物的流行。方法回顾性分析2018年9月1日至2019年8月31日美国印第安纳州马里恩县24家实验室的标准化、合并和关联毒理学结果。该数据集包括33,787名马里昂县居民和他们的746,681个结果。我们将数据与马里恩县的一般人口统计数据联系起来,并将毒理学结果产生的警报与阿片类药物过量相关的急诊就诊进行比较。19位领域专家帮助构建了分析可视化的原型。主要结果指标包括县和邮政编码的检测阳性情况;有毒理学结果的个体的选定人口统计学;毒理学结果与阿片类药物过量相关急诊科就诊的相关性。结果4%的马里恩县居民至少有1项毒理学结果。整个邮政编码的检测阳性率从3%到19%不等。男性在数据集中的代表性不足。年龄分布与马里恩县相似。阿片类药物毒理学结果警报与阿片类药物过量相关的急诊就诊无关。结论数据格式、完整性和代表性的差异阻碍了毒理学结果的大规模分析;数据输入的变化;病人匹配困难。在这项研究中,毒理学结果并不能预测阿片类药物过量的峰值。需要更大规模、更严格和控制良好的研究来评估毒理学试验在预测阿片类药物过量峰值方面的效用。
{"title":"Toxicology Test Results for Public Health Surveillance of the Opioid Epidemic: Retrospective Analysis","authors":"Titus Schleyer, Bill Robinson, Samir Parmar, Diane Janowiak, P Joseph Gibson, Val Spangler","doi":"10.2196/50936","DOIUrl":"https://doi.org/10.2196/50936","url":null,"abstract":"Background Addressing the opioid epidemic requires timely insights into population-level factors, such as trends in prevalence of legal and illegal substances, overdoses, and deaths. Objective This study aimed to examine whether toxicology test results of living individuals from a variety of sources could be useful in surveilling the opioid epidemic. Methods A retrospective analysis standardized, merged, and linked toxicology results from 24 laboratories in Marion County, Indiana, United States, from September 1, 2018, to August 31, 2019. The data set consisted of 33,787 Marion County residents and their 746,681 results. We related the data to general Marion County demographics and compared alerts generated by toxicology results to opioid overdose–related emergency department visits. Nineteen domain experts helped prototype analytical visualizations. Main outcome measures included test positivity in the county and by ZIP code; selected demographics of individuals with toxicology results; and correlation of toxicology results with opioid overdose–related emergency department visits. Results Four percent of Marion County residents had at least 1 toxicology result. Test positivity rates ranged from 3% to 19% across ZIP codes. Males were underrepresented in the data set. Age distribution resembled that of Marion County. Alerts for opioid toxicology results were not correlated with opioid overdose–related emergency department visits. Conclusions Analyzing toxicology results at scale was impeded by varying data formats, completeness, and representativeness; changes in data feeds; and patient matching difficulties. In this study, toxicology results did not predict spikes in opioid overdoses. Larger, more rigorous and well-controlled studies are needed to assess the utility of toxicology tests in predicting opioid overdose spikes.","PeriodicalId":74345,"journal":{"name":"Online journal of public health informatics","volume":"23 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135386889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Machine Learning Model for Predicting Mortality Risk in Complex Chronic Patients: Retrospective Analysis from the ProPCC Program in Catalonia (Preprint) 预测复杂慢性病患者死亡风险的机器学习模型:加泰罗尼亚 ProPCC 计划的回顾性分析(预印本)
Pub Date : 2023-09-15 DOI: 10.2196/52782
Guillem Hernández Guillamet, Ariadna Ning Morancho Pallaruelo, Laura Miró Mezquita, Ramón Miralles Basseda, Miquel Angel Mas Bergas, María José Ulldemolins Papaseit, Oriol Estrada Cuxart, Francesc López Seguí
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引用次数: 0
The Health Impact of mHealth Interventions in India: Systematic Review and Meta-Analysis. 印度移动医疗干预对健康的影响:系统回顾和荟萃分析
Pub Date : 2023-09-04 eCollection Date: 2023-01-01 DOI: 10.2196/50927
Vibha Joshi, Nitin Kumar Joshi, Pankaj Bhardwaj, Kuldeep Singh, Deepika Ojha, Yogesh Kumar Jain

Background: Considerable use of mobile health (mHealth) interventions has been seen, and these interventions have beneficial effects on health and health service delivery processes, especially in resource-limited settings. Various functionalities of mobile phones offer a range of opportunities for mHealth interventions.

Objective: This review aims to assess the health impact of mHealth interventions in India.

Methods: This systematic review and meta-analysis was conducted in accordance with the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. Studies conducted in India, and published between April 1, 2011, and March 31, 2021, were considered. A literature search was conducted using a combination of MeSH (Medical Subject Headings) terms in different databases to identify peer-reviewed publications. Thirteen out of 1350 articles were included for the final review. Risk of bias was assessed using the Risk of Bias 2 tool for RCTs and Risk Of Bias In Non-randomised Studies - of Interventions tool (for nonrandomized trials), and a meta-analysis was performed using RevMan for 3 comparable studies on maternal, neonatal, and child health.

Results: The meta-analysis showed improved usage of maternal and child health services including iron-folic acid supplementation (odds ratio [OR] 14.30, 95% CI 6.65-30.75), administration of both doses of the tetanus toxoid (OR 2.47, 95% CI 0.22-27.37), and attending 4 or more antenatal check-ups (OR 1.82, 95% CI 0.65-5.09). Meta-analysis for studies concerning economic evaluation and chronic diseases could not be performed due to heterogeneity. However, a positive economic impact was observed from a societal perspective (ReMiND [reducing maternal and newborn deaths] and ImTeCHO [Innovative Mobile Technology for Community Health Operation] interventions), and chronic disease interventions showed a positive impact on clinical outcomes, patient and provider satisfaction, app usage, and improvement in health behaviors.

Conclusions: This review provides a comprehensive overview of mHealth technology in all health sectors in India, analyzing both health and health care usage indicators for interventions focused on maternal and child health and chronic diseases.

Trial registration: PROSPERO 2021 CRD42021235315; https://tinyurl.com/yh4tp2j7.

移动健康干预措施已得到大量使用,这些干预措施对健康和卫生服务提供过程产生了有益影响,尤其是在资源有限的环境中。移动电话的各种功能为mHealth干预提供了一系列机会。本综述旨在评估mHealth干预措施对印度健康的影响。这项系统综述和荟萃分析是根据PRISMA(系统综述和元分析的首选报告项目)指南进行的。考虑了2011年4月1日至2021年3月31日期间在印度进行的研究。使用不同数据库中的MeSH(医学主题标题)术语组合进行文献检索,以确定同行评审的出版物。1350篇文章中有13篇被列入最后审查。使用随机对照试验中的“偏倚风险2”工具和非随机研究中的“干预措施的偏倚风险”工具(用于非随机试验)评估偏倚风险,并使用RevMan对孕产妇、新生儿和儿童健康的3项可比研究进行荟萃分析。荟萃分析显示,妇幼保健服务的使用有所改善,包括补充铁-叶酸(比值比[OR]14.30,95%CI 6.65-30.75)、两剂破伤风类毒素的给药(比值比2.47,95%CI 0.22-27.37)、,以及参加4次或4次以上的产前检查(or 1.82,95%CI 0.65-5.09)。由于异质性,无法对有关经济评估和慢性病的研究进行荟萃分析。然而,从社会角度观察到了积极的经济影响(ReMiND[减少孕产妇和新生儿死亡]和ImTeCHO[社区卫生运营创新移动技术]干预措施),慢性病干预措施对临床结果、患者和提供者满意度、应用程序使用和健康行为改善都有积极影响。这篇综述全面概述了印度所有卫生部门的mHealth技术,分析了针对妇幼健康和慢性病的干预措施的卫生和医疗保健使用指标。PROSPERO 2021 CRD42021235315;https://tinyurl.com/yh4tp2j7
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引用次数: 0
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Online journal of public health informatics
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