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Complementary and alternate therapies (CAM) in the management of novel Corona virus (COVID-19): protocol for systematic review and meta-analysis 新型冠状病毒(COVID-19)治疗中的补充和替代疗法(CAM):系统评价和荟萃分析方案
Pub Date : 2022-01-01 DOI: 10.1515/openhe-2022-0009
K. Maheshkumar, Vijayakumar. Venugopal, S. Geethanjali, S. Poonguzhali, S. Silambanan, R. Padmavathi, Sankaralingam Thirupathy Venkateswaran
Abstract Background: In December 2019, a new corona-virus (COVID-19) infection broke out in the Chinese province of Wuhan. With the rampant spread of virus around the world, COVID-19 was declared as a global pandemic in the following year. Many complementary and alternate therapies (CAM) were used experimentally alongside conventional treatments for effective management of COVID-19. Aim: This paper presents a protocol for the systematic review and meta-analysis of the studies with various CAM therapies for the management of COVID-19 pneumonia. Methods: Electronic databases such as PubMed, Embase, Scopus, and the Cochrane Central Register of Controlled Trials (CENTRAL) could be used for searching the relevant trials and studies with keywords related to COVID-19 and CAM therapies. Two independent reviewers would screen a list of all the trials and extract the relevant variables. Additionally, we would also evaluate the risk of bias of the selected studies. Review Manager software (RevMan; version 5.3.5) and R statistical software (version 3.6.1) would be used for the data analysis. Results: Risk ratio (RR) would be estimated for dichotomous outcomes, and the mean differences (MD) would be measured for continuous outcomes. Heterogeneity with the help of I2 statistic would be used for the assessment of inconsistency across studies with the level of significance at P< 0.10. We would also assess publication bias using funnel plots and Egger’s test for the selected studies. Conclusion: The protocol for systematic review and meta-analysis would investigate the beneficial and possible adverse effects of various CAM therapies in the prevention and management of COVID-19 associated pneumonia.
背景:2019年12月,中国武汉市发生新型冠状病毒(COVID-19)感染。随着新冠疫情在世界范围内的蔓延,第二年被宣布为全球大流行。许多补充和替代疗法(CAM)与常规治疗一起实验性地用于有效管理COVID-19。目的:本文提出了一种系统评价和荟萃分析各种CAM治疗COVID-19肺炎的研究方案。方法:通过PubMed、Embase、Scopus、Cochrane Central Register of Controlled Trials (Central)等电子数据库检索与COVID-19和CAM治疗相关的相关试验和研究。两名独立的审稿人将筛选所有试验的列表并提取相关变量。此外,我们还将评估所选研究的偏倚风险。Review Manager软件(RevMan;5.3.5版本)和R统计软件(3.6.1版本)进行数据分析。结果:二分结局的风险比(RR)将被估计,连续结局的平均差异(MD)将被测量。使用I2统计量的异质性来评估研究间的不一致性,显著性水平为P< 0.10。我们还会对选定的研究使用漏斗图和Egger检验来评估发表偏倚。结论:系统评价和荟萃分析方案将探讨各种CAM疗法在预防和管理COVID-19相关性肺炎中的有益和可能的不良影响。
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引用次数: 0
Healthy Lifestyle and Dietary Approaches to Treating Polycystic Ovary Syndrome: A Review 健康生活方式和饮食方法治疗多囊卵巢综合征:综述
Pub Date : 2022-01-01 DOI: 10.1515/openhe-2022-0008
Mehrukh Zehravi, Mudasir Maqbool, I. Ara
Abstract PCOS (Polycystic Ovary Syndrome) is an endocrine condition that affects women of reproductive age: it can have catastrophic consequences, as it is accompanied by anovulation, androgen excess, infertility, insulin resistance, depression, and amenorrhea. Women who have a hereditary tendency are more likely to be affected. Other environmental variables such as a sedentary lifestyle, bad eating habits, inactivity, and obesity have frequently been implicated in the development of this illness. Each year, more women are diagnosed with PCOS as a result of an increasingly unhealthy lifestyle. When PCOS is detected early and treated correctly, the accompanying reproductive, metabolic, and cardiovascular problems can be effectively managed or predicted. PCOS is becoming a growing source of worry, as it primarily affects women of reproductive age. PCOS is also prevalent in many teenage girls during puberty. Despite being one of the most frequent reproductive health issues among women, doctors face a tremendous obstacle in providing appropriate medical therapy. PCOS is known to cause anxiety and despair, particularly when exacerbated by excessive facial hair growth, obesity, and infertility, anxiety and despair. Thus, PCOS can have a negative effect on an individual’s quality of life if it is not treated promptly. The best first-line treatment for PCOS is a lifestyle intervention that includes a healthy diet with caloric restriction, exercise to aid in weight loss and to avoid future weight gain, and support for behaviour modification. Future studies should focus on the gaps in our understanding of PCOS. Patients will receive the best care if those physicians are followed. To date, there has been no effective treatment for PCOS, and most patients receive only symptomatic treatment with hormones and insulin sensitizers, which leads to long-term medication dependency.
PCOS (Polycystic ovarian Syndrome,多囊卵巢综合征)是一种影响育龄妇女的内分泌疾病,可伴随无排卵、雄激素过量、不孕症、胰岛素抵抗、抑郁和闭经,造成灾难性后果。有遗传倾向的女性更容易受到影响。其他环境变量,如久坐不动的生活方式、不良的饮食习惯、缺乏运动和肥胖,经常与这种疾病的发展有关。由于越来越不健康的生活方式,每年都有更多的女性被诊断为多囊卵巢综合征。当PCOS早期发现并正确治疗时,可有效控制或预测伴随的生殖、代谢和心血管问题。多囊卵巢综合征正日益成为人们担忧的根源,因为它主要影响育龄妇女。多囊卵巢综合征在青春期的许多少女中也很普遍。尽管这是妇女中最常见的生殖健康问题之一,但医生在提供适当的医疗方面面临巨大障碍。众所周知,多囊卵巢综合征会导致焦虑和绝望,尤其是当面部毛发过度生长、肥胖、不孕症、焦虑和绝望加剧时。因此,如果不及时治疗,多囊卵巢综合征会对个人的生活质量产生负面影响。多囊卵巢综合征的最佳一线治疗是生活方式干预,包括限制热量的健康饮食,帮助减肥和避免未来体重增加的运动,以及支持行为改变。未来的研究应关注我们对多囊卵巢综合征认识的空白。如果遵医嘱,病人将得到最好的治疗。迄今为止,PCOS还没有有效的治疗方法,大多数患者仅接受激素和胰岛素增敏剂的对症治疗,导致长期药物依赖。
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引用次数: 2
Commitment, Concessions and Compromise. Experiences of building support for and addressing resistance to sexuality education from Nigeria 承诺、让步和妥协。尼日利亚为性教育建立支持和解决抵制性教育的经验
Pub Date : 2022-01-01 DOI: 10.1515/openhe-2022-0027
Emmanuel S Adebayo, Abiodun Omowunmi Essiet, M. Plesons, Katherine Kat Watson, V. Chandra-Mouli
Abstract Despite the international, regional and national commitments to sexuality education and the evidence of its effectiveness, progress on national implementation of sexuality education has been slow for a variety of reasons. The obstacles to comprehensive sexuality education are well documented and commonly experienced, yet the knowledge base of successful strategies to deal with resistance remain limited. This study evaluated Nigeria’s experience in creating an enabling environment for and addressing backlash to the Family Life and HIV Education (FLHE) programme; the findings reveal that FLHE supporters used both proactive and reactive strategies, whilst also making concessions and compromises to ensure the acceptance of the programme in various states of the country. These practical examples from Nigeria may inspire other countries in the planning, implementation and scale-up phases of their own CSE programmes, especially in settings where socio-cultural barriers pose challenges.
尽管国际、地区和国家对性教育做出了承诺,并有证据表明其有效性,但由于种种原因,国家实施性教育的进展缓慢。全面的性教育的障碍是有据可查的,也是大家都经历过的,然而,关于处理抵制的成功策略的知识基础仍然有限。本研究评估了尼日利亚在为家庭生活和艾滋病毒教育(FLHE)方案创造有利环境和解决反对意见方面的经验;调查结果显示,FLHE的支持者既采取了主动战略,也采取了被动战略,同时也做出了让步和妥协,以确保该计划在该国各个州得到接受。尼日利亚的这些实际例子可能会激励其他国家在规划、实施和扩大本国CSE方案的阶段,特别是在社会文化障碍构成挑战的环境中。
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引用次数: 0
A pilot study exploring the relationship between urban greenspace accessibility and mental health prevalence in the City of San Diego in the context of socioeconomic and demographic factors 在社会经济和人口因素的背景下,探索圣地亚哥市城市绿地可达性与心理健康患病率之间关系的试点研究
Pub Date : 2021-01-01 DOI: 10.1515/openhe-2021-0004
Alexis Wilderman, Marcus M. Lam, Z. Yin
Abstract The connection between urban greenspace and mental health is a robust but unsettled area of research in the public health and urban planning literatures. Inconsistent findings in prior studies are mostly due to differences in greenspace measurements and interrelations with socio-demographic factors. This study examines the relationships of mental health prevalence (MHP) with health prevention, socioeconomic and race-ethnicity factors, and proximity to greenspace at the census-tract level in the City of San Diego, California, using data from the CDC 500 Cities Project and US Census Bureau. We considered three greenspace proximity measures: distances to specified vegetation types, parks, and tree cover. Spear-man’s rank correlation showed that MHP was significantly correlated to distances to greenspace (rho = 0.480), parks (rho = 0.234), and tree cover (rho = 0.342), and greenspace proximity plus crime occurrence explained 37.8% of the variance in MHP in regression analysis. Further analysis revealed that socioeconomic status, race-ethnicity, and health prevention explained more than 93% of the variance in MHP, while greenspace proximity did not enter the regression model with statistical significance. We discovered that certain socioeconomic and race-ethnicity variables, such as proportion of Hispanic population, poverty, and regular checkup, may fully represent the effects of greenspace on MHP in the City of San Diego. Regression analysis for three subsections of the city suggested that different predictors of MHP should be considered in formulating intervention measures. Our results indicate the need to improve mental health conditions through a range of interventions that address the disparities experienced by racial-ethnic minorities and those in lower-socioeconomic classes.
城市绿地与心理健康之间的关系是公共卫生和城市规划文献中一个活跃但不稳定的研究领域。以往研究中不一致的发现主要是由于绿地测量的差异以及与社会人口因素的相互关系。本研究利用美国疾病控制与预防中心500个城市项目和美国人口普查局的数据,研究了加利福尼亚州圣地亚哥市人口普查区的心理健康患病率(MHP)与健康预防、社会经济和种族因素以及与绿地的接近程度之间的关系。我们考虑了三种绿地接近度指标:与特定植被类型、公园和树木覆盖的距离。spearman秩相关分析显示,城市绿地面积与绿地距离(rho = 0.480)、公园距离(rho = 0.234)、树木覆盖距离(rho = 0.342)显著相关,绿地距离与犯罪发生的关系解释了37.8%的MHP方差。进一步的分析表明,社会经济地位、种族和健康预防解释了93%以上的MHP方差,而绿地邻近性没有进入回归模型,具有统计学意义。我们发现某些社会经济和种族变量,如西班牙裔人口比例、贫困和定期体检,可能完全代表绿地对圣地亚哥市MHP的影响。回归分析表明,在制定干预措施时应考虑不同的MHP预测因子。我们的研究结果表明,需要通过一系列干预措施来改善心理健康状况,以解决种族少数民族和社会经济较低阶层的人所经历的差异。
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引用次数: 1
COVID-19 and the 1918 influenza pandemics: a concise overview and lessons from the past 2019冠状病毒病和1918年流感大流行:简明概述和过去的教训
Pub Date : 2021-01-01 DOI: 10.1515/openhe-2021-0003
M. Asghar, M. Din, A. Waris, Muhammad Talha Yasin, T. Zohra, M. Zia
Abstract The coronavirus disease 2019 (COVID-19), which is caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), was first reported in December, 2019, in Wuhan, China. Even the public health sector experts could not anticipate that the virus would spread rapidly to create the worst worldwide crisis in more than a century. The World Health Organization (WHO) declared COVID-19 a public health emergency on January 30, 2020, but it was not until March 11, 2020 that the WHO declared it a global pandemic. The epidemiology of SARS-CoV-2 is different from the SARS coronavirus outbreak in 2002 and the Middle East Respiratory Syndrome (MERS) in 2012; therefore, neither SARS nor MERS could be used as a suitable model for foreseeing the future of the current pandemic. The influenza pandemic of 1918 could be referred to in order to understand and control the COVID-19 pandemic. Although influenza and the SARS-CoV-2 are from different families of viruses, they are similar in that both silently attacked the world and the societal and political responses to both pandemics have been very much alike. Previously, the 1918 influenza pandemic and unpredictability of the second wave caused distress among people as the first wave of that outbreak (so-called Spanish flu) proved to be relatively mild compared to a much worse second wave, followed by smaller waves. As of April, 2021, the second wave of COVID-19 has occurred around the globe, and future waves may also be expected, if the total population of the world is not vaccinated. This article aims to highlight the key similarities and differences in both pandemics. Similarly, lessons from the previous pan-demics and various possibilities for the future course of COVID-19 are also highlighted.
2019年12月,由严重急性呼吸综合征冠状病毒-2 (SARS-CoV-2)引起的冠状病毒病2019 (COVID-19)在中国武汉首次报道。即使是公共卫生部门的专家也没有预料到这种病毒会迅速传播,造成一个多世纪以来最严重的全球危机。2020年1月30日,世界卫生组织宣布COVID-19为突发公共卫生事件,但直到2020年3月11日,世界卫生组织才宣布其为全球大流行。SARS- cov -2与2002年SARS冠状病毒疫情和2012年中东呼吸综合征(MERS)疫情的流行病学差异;因此,SARS和中东呼吸综合征都不能作为预测当前大流行未来的合适模型。为了了解和控制COVID-19大流行,可以参考1918年的流感大流行。尽管流感和SARS-CoV-2属于不同的病毒家族,但它们的相似之处在于,它们都在悄无声息地袭击世界,对这两种大流行的社会和政治反应也非常相似。此前,1918年的流感大流行和第二波流感的不可预测性给人们带来了痛苦,因为与更严重的第二波流感相比,第一波流感(所谓的西班牙流感)的爆发相对温和。截至2021年4月,全球已经出现了第二波COVID-19,如果世界总人口不接种疫苗,还可能出现未来的浪潮。本文旨在强调这两种流行病的主要相似点和不同点。同样,还强调了以往大流行病的教训以及COVID-19未来发展的各种可能性。
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引用次数: 1
Structural equation modeling of mental health in gentrifying neighborhoods in Austin, Texas 得克萨斯州奥斯汀市中产阶级化社区的心理健康结构方程模型
Pub Date : 2021-01-01 DOI: 10.1515/openhe-2021-0002
A. Iyanda, Yongmei Lu
Abstract Having poor mental health can be life-threatening, and problems tied to it are prevalent in communities across the United States (US). The city of Austin is one of the ten cities in the US undergoing rapid urban gentrification; however, there is insufficient empirical evidence on the impact of this process on residents’ health. Consequently, this study explored the concept of weathering and life course perspective using data of 331 residents recruited from two regions endemic with gentrification to assess the health impacts of gentrification. We used a triangulation method including univariate, bivariate correlation, and multiple linear regression implemented through the structural equation model to examine the complex pathways to three health outcomes—measured stress, self-rated mental health, and depression symptoms. Bivariate Pearson’s correlation indicated a significant positive association between gentrification score and mental health symptoms and stress. However, the direct association between gentrification and depression disappeared in the causal/path model. In support of the weathering hypothesis, this study found that stress score was directly related to the adulthood depression score. Therefore, this research builds on the accumulating evidence of environmental stress and mental health in the US’s rapidly changing physical and sociocultural environment. Hence, implementing and guaranteeing social equity of resources will improve residents’ health and reduce the cost of health care spending at both the household level and the city government level.
心理健康状况不佳可能危及生命,与之相关的问题在美国各地的社区都很普遍。奥斯汀市是美国正在经历快速中产阶级化的十个城市之一;然而,这一过程对居民健康影响的实证证据不足。因此,本研究利用从两个高档化地区招募的331名居民的数据,探索了风化和生命历程视角的概念,以评估高档化对健康的影响。我们使用三角测量方法,包括单变量、双变量相关,以及通过结构方程模型实现的多元线性回归,来检验三种健康结果(测量压力、自评心理健康和抑郁症状)的复杂途径。双变量Pearson相关分析表明,高档化评分与心理健康症状和压力之间存在显著正相关。然而,在因果/路径模型中,中产阶级化与抑郁之间的直接联系消失了。为了支持风化假说,本研究发现压力得分与成年期抑郁得分直接相关。因此,这项研究建立在美国快速变化的物质和社会文化环境中环境压力和心理健康的积累证据的基础上。因此,实施和保障资源的社会公平,无论是在家庭层面还是在市政府层面,都将提高居民的健康水平,降低医疗支出成本。
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引用次数: 3
VectorNet Data Series 3: Culicoides Abundance Distribution Models for Europe and Surrounding Regions VectorNet数据系列3:欧洲及周边地区的库蚊丰度分布模型
Pub Date : 2020-09-16 DOI: 10.5334/OHD.33
T. Balenghien, N. Alexander, Auður Lilja Arnþórsdóttir, Marina G. Bisia, A. Blackwell, R. Bødker, Maria Bourquia, S. Boutsini, S. Carpenter, C. Colenutt, Lorna Culverwell, Aleksandar Cvetkovikj, L. Dascălu, N. De Regge, S. Dhollander, A. Elbers, M. England, S. Filatov, C. Garros, M. Goffredo, N. Haddad, T. Høye, D. Hristescu, K. Khallaayoune, A. Kočišová, M. Larska, J. Lucientes, B. Mathieu, M. Miranda, A. Murchie, C. Nițescu, Z. Ozoliņa, I. P. da Fonseca, D. Petrić, D. Pudar, D. Ramilo, J. Richardson, Zanda Segliņa, S. Sghaier, J. Stefanovska, D. Stougiou, S. Sviland, Simona Tchakarova, W. Van Bortel, M. Castello, E. Veronesi, V. Versteirt, W. Wint
This is the third in a planned series of data papers presenting modelled vector distributions produced during the ECDC and EFSA funded VectorNet project. The data package presented here includes those Culicoides vectors species first modelled in 2015 as part of the VectorNet gap analysis work namely C. imicola, C. obsoletus, C. scoticus, C. dewulfi, C. chiopterus, C. pulicaris, C. lupicaris, C. punctatus, and C. newsteadi. The known distributions of these species within the Project area (Europe, the Mediterranean Basin, North Africa, and Eurasia) are currently incomplete to a greater or lesser degree. The models are designed to fill the gaps with predicted distributions, to provide a) first indication of vector species distributions across the project geographical extent, and b) assistance in targeting surveys to collect distribution data for those areas with no field validated information. The models are based on input data from light trap surveillance of adult Culicoides across continental Europe and surrounding regions (71.8°N –33.5°S, – 11.2°W – 62°E), concentrated in Western countries, supplemented by transect samples in eastern and northern Europe. Data from central EU are relatively sparse. Funding statement: This work was carried out with support from the VectorNet framework contract OC/EFSA/AHAW/2013/02-FWC1 funded by the European Centre for Disease prevention and Control (ECDC) and the European Food Safety Agency (EFSA) and the PALE-Blu H2020 Project ID: 727393.
这是计划中的一系列数据论文中的第三篇,这些论文介绍了ECDC和EFSA资助的VectorNet项目期间产生的建模矢量分布。这里提供的数据包包括2015年作为VectorNet缺口分析工作的一部分首次建模的库蚊类媒介物种,即米曲霉、obsoletus、scoticus、deulsuli、chiopterus、pulicaris、lupicaris、punctatus和newsteadi。这些物种在项目区域(欧洲、地中海盆地、北非和欧亚大陆)内的已知分布目前或多或少都不完整。这些模型旨在用预测的分布填补空白,以提供a)整个项目地理范围内病媒物种分布的首次指示,以及b)协助进行目标调查,以收集那些没有现场验证信息的地区的分布数据。该模型基于欧洲大陆及其周边地区(71.8°N–33.5°S,–11.2°W–62°E)成年库蚊的光阱监测输入数据,集中在西方国家,并辅以东欧和北欧的样带样本。来自欧盟中部的数据相对稀少。资金声明:这项工作是在VectorNet框架合同OC/EFSA/AHAW/2013/02-FWC1的支持下进行的,该合同由欧洲疾病预防与控制中心(ECDC)和欧洲食品安全局(EFSA)以及PALE Blu H2020项目ID:727393资助。
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引用次数: 1
Coccidioidomycosis (Valley Fever) Case Data for the Southwestern United States 美国西南部球虫病(山谷热)病例数据
Pub Date : 2020-04-22 DOI: 10.5334/ohd.31
M. Gorris, L. Cat, M. Matlock, O. Ogunseitan, K. Treseder, J. Randerson, C. Zender
We compiled a coccidioidomycosis (Valley fever) case database for three states in the southwestern United States (US). Currently, county-level, monthly case counts are available from 2000–2015 for Arizona, California, and Nevada. We collected these data from each respective state public health agency. The Valley fever case database is available on GitHub, at https://github.com/valleyfever/valleyfevercasedata . This database may be used to examine relationships between the number of Valley fever cases and hypothesized explanatory variables such as environmental conditions, social determinants, human behavior, occupational activities, public policies, or other risk factors. We aim to provide regular updates to this database and include more states as data become available. Funding statement: M. E. Gorris received support from a Department of Defense (DoD), National Defense Science & Engineering Graduate Fellowship (32 CFR 168a). M. E. Gorris, L. A. Cat, and M. Matlock thank the UC Irvine Data Science Initiative for their funding and support. L. A. Cat acknowledges funding and support from the UC-Mexico Initiative. M. Matlock is also supported by Water UCI and the UCI Graduate Division. K. K. Treseder is supported by US NSF (EAR-1411942 and DEB-1457160) and the US Department of Energy, Office of Science, Office of Biological and Environmental Research (BER), under Award Numbers DE-PS02-09ER09-25 and DE-SC001641. J. T. Randerson received support from the Gordon and Betty Moore Foundation (GBMF#3269), NASA Soil Moisture and Interdisciplinary Science Program, and the U.S. Dept. of Energy Office of Science RUBISCO Science Focus Area. C. S. Zender acknowledges support from the Borrego Valley Endowment Fund and DOE ACME DE-SC0012998.
我们编制了美国西南部三个州的球孢子菌病(谷热)病例数据库。目前,从2000年到2015年,亚利桑那州、加利福尼亚州和内华达州的县级每月病例计数是可用的。我们从每个州的公共卫生机构收集了这些数据。谷热病例数据库可以在GitHub上找到,网址是https://github.com/valleyfever/valleyfevercasedata。该数据库可用于检查谷热病例数与假设的解释变量(如环境条件、社会决定因素、人类行为、职业活动、公共政策或其他风险因素)之间的关系。我们的目标是为这个数据库提供定期更新,并在数据可用时包括更多的州。资助声明:m.e. Gorris获得了国防部(DoD)国防科学与工程研究生奖学金(32 CFR 168a)的支持。M. E. Gorris, L. A. Cat和M. Matlock感谢加州大学欧文分校数据科学计划的资助和支持。L. A. Cat感谢加州大学墨西哥分校倡议的资助和支持。马特洛克也得到了水UCI和UCI研究生部的支持。K. K. Treseder项目由美国国家科学基金会(EAR-1411942和DEB-1457160)和美国能源部、科学办公室、生物与环境研究办公室(BER)资助,项目编号为DE-PS02-09ER09-25和DE-SC001641。J. T. Randerson得到了Gordon and Betty Moore基金会(gbmf# 3269)、NASA土壤水分和跨学科科学计划以及美国能源部科学办公室RUBISCO科学重点领域的支持。C. S. Zender感谢Borrego Valley捐赠基金和DOE ACME DE-SC0012998的支持。
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引用次数: 5
Expressing the quantity of urinary analytes: a discussion of some issues arising from the monitoring of the menstrual cycle 表达尿液分析物的数量:月经周期监测引起的一些问题的讨论
Pub Date : 2020-01-01 DOI: 10.1515/openhe-2020-0001
Simon Brown, D. Cooke, L. Blackwell
Abstract Practical domestic monitoring of the menstrual cycle requires measurements of urinary metabolites of reproductive hormones: oestrone glucuronide (E1G) and pregnanediol glucuronide (PdG). Data reported in the literature are expressed as (i) concentration, without or with either creatinine- or specific gravity correction, or (ii) excretion rates. This variation in such a fundamental issue prompts consideration of the relationships between the four measures. Because the menstrual cycle kinetics of E1G and PdG are complex, we consider measurements of urinary creatinine, urea, galactose, xylose and inulin which tend to be more stable. We show that uncorrected concentration measurements of these urinary analytes can be positively correlated, negatively correlated or uncorrelated with the serum concentration. Based on measurements of urinary creatinine concentrations, urinary specific gravity and creatinine excretion rates, we conclude that urinary analyte concentration are likely to be more reliable when creatinine-corrected rather than corrected using specific gravity, but that both are less reliable than measurements of the excretion rate. This has implications for the quantitation of any urinary analyte, but especially for the monitoring of the menstrual cycle in which changes in E1G and PdG from one day to the next can be physiologically significant for a woman monitoring her fertility.
国内实际的月经周期监测需要测量生殖激素的尿代谢产物:雌酮葡萄糖醛酸盐(E1G)和妊娠二醇葡萄糖醛酸盐(PdG)。文献中报告的数据表示为(i)没有或有肌酐或比重校正的浓度,或(ii)排泄率。在这样一个基本问题上的这种变化促使人们考虑这四种措施之间的关系。由于E1G和PdG的月经周期动力学是复杂的,我们考虑尿肌酐、尿素、半乳糖、木糖和菊粉的测量往往更稳定。我们表明,这些尿液分析物的未经校正的浓度测量可以与血清浓度正相关,负相关或不相关。基于对尿肌酐浓度、尿比重和肌酐排泄率的测量,我们得出结论,用肌酐校正尿液分析物浓度可能比用比重校正更可靠,但两者都不如用排泄率测量可靠。这对任何尿液分析物的定量都有意义,尤其是对月经周期的监测,因为一天到第二天的E1G和PdG的变化对女性监测其生育能力具有重要的生理意义。
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引用次数: 3
Social context affects mental health stigma 社会背景影响心理健康污名
Pub Date : 2020-01-01 DOI: 10.1515/openhe-2020-0003
Oliver Boxell
Abstract Prior research shows mental health stigma is context-dependent and blocks help-seeking behaviors. Any applied solutions will require basic research to understand these contextual nuances. The present paper presents two timed Likert-type rating studies in which participants scored photographs of individuals with mental health diagnoses and other control condition labels in different social contexts. In the first study (N = 99), participants rated the individuals in a professional context and in a non-professional context. The second study (N = 99) systematically manipulated the attractiveness of the individuals depicted. Professional context moderated mental health stigma, indicating that, relative to control label conditions, participants were less accepting of an individual with a mental health diagnosis label as a medical clinician than as a next-door neighbor. Attractiveness had a uniform effect across all the label conditions, which produced a compounding additive effect in which a mental health diagnosis and low attractiveness negatively impacted the ratings simultaneously. The study used timed implicit judgments to demonstrate empirically how previously unstudied social contexts can affect mental health stigma. Understanding how such contextual effects affect stigma is a prerequisite for the development of interventions to overcome the barriers stigma creates for access to treatment and prevention.
先前的研究表明,心理健康耻辱是情境依赖的,并阻碍了寻求帮助的行为。任何应用的解决方案都需要基础研究来理解这些上下文的细微差别。本论文提出了两个时间李克特型评分研究,在这些研究中,参与者在不同的社会背景下对患有精神健康诊断和其他控制条件标签的个体的照片进行评分。在第一项研究中(N = 99),参与者在专业环境和非专业环境中对个体进行评分。第二项研究(N = 99)系统地操纵了所描绘的个人的吸引力。专业背景缓和了心理健康的耻辱感,这表明,相对于对照标签条件,参与者更不愿意接受一个有心理健康诊断标签的人作为医学临床医生,而不是作为隔壁邻居。吸引力在所有标签条件下都有统一的影响,这产生了复合叠加效应,其中心理健康诊断和低吸引力同时对评分产生负面影响。该研究使用了时间内隐判断来实证证明以前未研究的社会背景如何影响心理健康耻辱感。了解这种背景效应如何影响耻辱是制定干预措施以克服耻辱对获得治疗和预防造成的障碍的先决条件。
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引用次数: 2
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Open health data
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