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Prevalence of diaper need and diaper dermatitis and associated risk factors among children aged 1–24 months in a referral hospital in Ghana: A cross-sectional study 加纳一家转诊医院1-24月龄儿童尿布需求和尿布皮炎患病率及相关危险因素:一项横断面研究
Pub Date : 2023-01-01 DOI: 10.1515/ohe-2022-0033
Abdul-Wahab Inusah, Gbeti Collins, Peter Gyamfi Kwarteng, P. Dzomeku, M. Asumah, S. Ziblim
Abstract Objectives This research aimed to determine the prevalence of diaper need and diaper dermatitis (DD) and associated risk factors in children aged 1–24 months. Methods Data were collected through face-to-face exit interviews with 456 mothers at a Child Welfare Clinic. A chi-square, correlation, and multivariate logistic regression analyses at a significance level of p < 0.05 were conducted. Results The prevalence of diaper need was found to be 53.5%, with lower odds observed in households with monthly incomes greater than $167 and in children on breastmilk only. Diaper need was higher in parents with no formal education and use of disposable diapers. The prevalence of DD was 27.4%, with lower odds observed in households with monthly incomes greater than $167 and in children less than 6 months old and on breastmilk only. There was a moderately positive correlation between diaper need and DD. Conclusion The researchers recommend affordable alternative diapering methods and educating parents on the importance of frequent diaper changes to improve the prevalence of diaper need and DD. Overall, this study highlights the significant prevalence of diaper need and DD among children and identifies the important associated risk factors.
摘要目的了解1-24月龄儿童尿布需求、尿布皮炎(DD)患病率及相关危险因素。方法对某儿童福利诊所的456名母亲进行离职面谈。在p < 0.05的显著性水平上进行卡方、相关和多因素logistic回归分析。结果发现尿布需求的患病率为53.5%,月收入大于167美元的家庭和仅母乳喂养的儿童的患病率较低。没有接受过正规教育且使用一次性尿布的父母对尿布的需求更高。DD的患病率为27.4%,在月收入超过167美元的家庭和6个月以下仅母乳喂养的儿童中,DD的患病率较低。研究人员推荐了可负担的替代尿布方法,并教育家长频繁更换尿布的重要性,以提高尿布需求和DD的患病率。总体而言,本研究强调了尿布需求和DD在儿童中的显著患病率,并确定了重要的相关风险因素。
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引用次数: 0
Social factors related to depression during COVID-19 COVID-19期间与抑郁相关的社会因素
Pub Date : 2023-01-01 DOI: 10.1515/ohe-2022-0030
Katherine Aumer, Michael A. Erickson, Eli Tsukayama
Abstract Background Depression can impact both the administration and efficacy of vaccines. Identifying social factors that contribute to depression, especially during a pandemic, is important for both current and future public health issues. Publicly available data can help identify key social factors contributing to depression. Method For each US state, information regarding their change in depression as measured by the Patient Health Questionnaire 2, predominant political affiliation, coronavirus disease 19 cases/100k, and lockdown severity were gathered. Structural equation modeling using latent change scores was conducted to assess the longitudinal relationships among depression, cases/100k, and state social restrictions. Results Higher initial levels of lockdown severity and depression predicted rank-order decreases in themselves over time. Correlations among the latent change variables reveal that changes in lockdown severity are negatively related to changes in cases/100k and changes in lockdown severity are positively related to changes in depression after controlling for the other variables. Conclusion Significant rank-order decreases in depression from T1 to T2 in blue states (who tend to vote for Democrats) vs red states (who tend to vote for Republicans) suggest that decreases in depression may be impacted by the population density and/or political views of that state. Rank-order increases in lockdown measures were negatively associated with rank-order increases in COVID-19 infections, demonstrating strong evidence that lockdown measures do help decrease the spread of COVID-19. Political affiliation and/or population density should be measured and assessed to help facilitate future public health efforts.
背景抑郁症可以影响疫苗的给药和疗效。确定导致抑郁症的社会因素,特别是在大流行期间,对当前和未来的公共卫生问题都很重要。公开可用的数据可以帮助确定导致抑郁症的关键社会因素。方法收集美国各州通过患者健康问卷2、主要政治派别、冠状病毒疾病19例/100k和封锁严重程度测量的抑郁症变化信息。使用潜在变化评分的结构方程模型来评估抑郁、病例/100k和州社会限制之间的纵向关系。结果较高的禁闭严重程度和抑郁初始水平预示着随着时间的推移,他们自己的等级顺序会下降。潜在变化变量之间的相关性表明,在控制其他变量后,封严程度的变化与病例/100k的变化呈负相关,封严程度的变化与抑郁症的变化呈正相关。在蓝色州(倾向于投票给民主党人)和红色州(倾向于投票给共和党人),抑郁症的显著等级从T1到T2下降表明抑郁症的减少可能受到该州人口密度和/或政治观点的影响。封锁措施的等级顺序增加与COVID-19感染的等级顺序增加呈负相关,这有力地证明了封锁措施确实有助于减少COVID-19的传播。应衡量和评估政治派别和(或)人口密度,以帮助促进今后的公共卫生工作。
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引用次数: 0
Allelic variants of CYP2B6 gene expression and its implication on the pathogenesis of malaria among a cohort of outpatients in North-Central Nigeria 尼日利亚中北部门诊患者中CYP2B6基因表达的等位变异及其与疟疾发病机制的关系
Pub Date : 2023-01-01 DOI: 10.1515/ohe-2023-0004
Olalere Shittu, Mobolanle Oladipo Oniya, Titus Adeniyi Olusi
Abstract Background Human cytochrome P450 2B6 (CYP2B6) is fortified with the biotransformation of the antimalarial, artemisinin combination therapy (ACT). Owing to emerging reports of Plasmodium species resistance to ACT in other climes, CYP2B6*6 genotype significantly alters ACT metabolism. In North-Central Nigeria, the distribution of the CYP2B6*6 variant is poorly documented. This study investigated the distribution of CYP2B6 c.516G>T variants and its relationship with certain malaria pathogenesis among a cohort of clinical-malaria outpatients in Ilorin, Nigeria. Methods A total of 50 symptomatic P. falciparum malaria-positive samples were genotyped for CYP2B6 c.516G>T using restriction fragment length polymorphism and a specific haplotype population was established. The allele frequencies and genotype distributions were analyzed. Haplotypes were clustered using Ward’s method. Correlations determined include defective CYP2B6 versus parasitemia densities and thrombocytopenia, respectively. Results Forty-five samples show genotypic ratios and nine CYP2B6 genetic single nucleotide polymorphisms were identified. The following haplotypes (64C>T = *1/*2, 785A>G = *1/*4, and 1459C>T = *1/*5) occurred and *2, *3, and *18 alleles harbor 64C>T, 777C>A, −82T>C, and 499C>G. The codon 64CT, 516GT, and 785AG; −82TC and 777CA; and 499CG, 516GT, and 785AG were identified as *2/*6 heterozygotes. Samples with 516GT and 785GG genotypes occurred with *4/*6 heterozygotes. Mutant trait alleles recorded high parasitemia 72 h post-ACT regimen. Only individuals with CYP2B6*6 alleles had severe malaria and thrombocytopenia. Conclusion This report contributes to the growing knowledge of CYP2B6*6 genotype frequency and its relationship with malaria pathogenesis among a Nigerian population.
摘要背景人细胞色素P450 2B6 (CYP2B6)通过抗疟青蒿素联合治疗(ACT)的生物转化得到强化。由于在其他气候条件下出现的疟原虫对ACT的抗性报道,CYP2B6*6基因型显著改变ACT的代谢。在尼日利亚中北部,CYP2B6*6变异的分布文献很少。本研究调查了CYP2B6 c.516G>T变异在尼日利亚伊洛林一组临床疟疾门诊患者中的分布及其与某些疟疾发病机制的关系。方法采用限制性内切片段长度多态性对50例有症状的恶性疟原虫疟疾阳性样本进行CYP2B6 c.516G>T基因分型,建立特异性单倍型群体。分析等位基因频率和基因型分布。单倍型采用Ward的方法聚类。确定的相关性包括CYP2B6缺陷分别与寄生虫血症密度和血小板减少症。结果45份样本具有基因型比,鉴定出9个CYP2B6基因单核苷酸多态性。发生了以下单倍型(64C>T = *1/*2, 785A>G = *1/*4, 1459C>T = *1/*5), *2, *3和*18等位基因携带64C>T, 777C>A, - 82T>C和499C>G。密码子64CT、516GT、785AG;−82TC和777CA;499CG、516GT和785AG为*2/*6杂合子。516GT和785GG基因型样品出现*4/*6杂合子。突变性状等位基因在act方案后72小时记录了高寄生虫率。只有携带CYP2B6*6等位基因的个体有严重的疟疾和血小板减少症。结论本报告有助于进一步了解尼日利亚人群CYP2B6*6基因型频率及其与疟疾发病机制的关系。
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引用次数: 0
Impact of medically supervised fasting on the vitamin D, glycemic control, quality of life and need for medication among type 2 diabetes mellitus: Protocol for a randomized control trial (FAVIT Trial) 医学监督下禁食对2型糖尿病患者维生素D、血糖控制、生活质量和药物需求的影响:随机对照试验方案(FAVIT试验)
Pub Date : 2023-01-01 DOI: 10.1515/ohe-2023-0010
Pradeep M. K. Nair, Karishma Silwal, Prakash Babu Kodali, Hemanshu Sharma, Gulab Rai Tewani
Abstract Objective The objective of this study is to investigate the effect of prolonged medically supervised fasting (PMSF) for 6 months on vitamin D levels and diabetes-related clinical outcomes in type 2 diabetes mellitus (T2DM) patients. Methods This is an open-label, parallel arm, randomized control trial; 170 T2DM patients from a complementary medicine setting, aged between 20 and 70 years, with a body mass index >25 kg/m2 and glycated hemoglobin (HbA1C) levels >6% and <12%, treated with lifestyle advice and/or oral hypoglycemic drugs, will be randomized to receive PMSF or a diabetic diet (DD), along with their usual care. The patients will be initially trained in PMSF and DD for a duration of 10 days in the study setting, followed by 5 months of practice at their respective residences. The PMSF will fast for five days a month for three consecutive months after the initial exposure, whereas the DD group will follow the same diet for 6 months. Other than fasting days, the PMSF group will follow the same DD as the control group. The primary outcome is an improvement in vitamin D levels, and the secondary outcomes include serum calcium, insulin levels, insulin resistance, blood cell counts, anthropometrics, quality of life, medication score, compliance rate, and disease perception. Discussion In this study, we hypothesize that PMSF would gradually increase vitamin D levels, which would increase calcium levels, which would promote insulin secretion and upregulate its function. This may help reduce the need for diabetic medication and result in diabetic remission.
摘要目的探讨延长医学监督禁食(PMSF) 6个月对2型糖尿病(T2DM)患者维生素D水平和糖尿病相关临床结局的影响。方法:这是一项开放标签、平行对照、随机对照试验;来自补充医学环境的170例T2DM患者,年龄在20至70岁之间,体重指数为25 kg/ m2,糖化血红蛋白(HbA1C)水平为6%至12%,接受生活方式建议和/或口服降糖药治疗,随机接受PMSF或糖尿病饮食(DD),以及他们的常规护理。患者最初将在研究环境中接受为期10天的PMSF和DD培训,然后在各自的住所进行5个月的实践。在首次接触后,PMSF组将每月禁食五天,连续三个月,而DD组将遵循相同的饮食6个月。除禁食日外,PMSF组将遵循与对照组相同的DD。主要结局是维生素D水平的改善,次要结局包括血清钙、胰岛素水平、胰岛素抵抗、血细胞计数、人体测量、生活质量、用药评分、依从率和疾病感知。在本研究中,我们假设PMSF会逐渐增加维生素D水平,从而增加钙水平,从而促进胰岛素分泌并上调其功能。这可能有助于减少对糖尿病药物的需求,并导致糖尿病缓解。
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引用次数: 0
A gravity model approach to understand the spread of pandemics: Evidence from the COVID-19 outbreak 理解大流行传播的重力模型方法:来自COVID-19爆发的证据
Pub Date : 2023-01-01 DOI: 10.1515/ohe-2022-0032
Albert Opoku Frimpong, Kwadwo Arhin, M. Boachie, Kwame Acheampong
Abstract Pandemics disrupt the global economy. Understanding the transmission pattern of pandemics informs policies to prevent or reduce the catastrophic consequences associated with pandemics. In this study, we applied the gravity model of trade to investigate the transmission pattern of the coronavirus disease 2019 (COVID-19) across countries. The results suggest an outbreak in a country is likely to spread faster (slower) from a shrinking (booming) economy to a booming (shrinking) economy.
流行病扰乱了全球经济。了解大流行的传播模式可以为预防或减少与大流行相关的灾难性后果的政策提供信息。在这项研究中,我们应用贸易重力模型研究了2019冠状病毒病(COVID-19)的跨国传播模式。结果表明,一个国家的疫情可能会更快(更慢)地从一个萎缩(繁荣)的经济体传播到另一个繁荣(萎缩)的经济体。
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引用次数: 0
Recomposition of work and attitudes of family assistants within Covid-19 in Poland: A pilot study 波兰Covid-19期间家庭助理工作和态度的重组:一项试点研究
Pub Date : 2023-01-01 DOI: 10.1515/ohe-2022-0034
Monika Anna Budnik
Abstract This article presents reflections on the consequence of remote work in social welfare professions in the case of family assistants. Web surveys focused on changes that came with the pandemic crisis in social welfare programs, such as family assistants. The article presents conclusions from the pilot web survey study among family assistants in June 2020 using the Survey Monkey online web survey questionnaire. Family assistants of Lower Silesia (part of the region in Poland) represent a category of professions in the social welfare system in Poland. They are employed in social welfare centers and work in the local community. The assistant has different tasks and eligibility than social workers. The family assistant knows the background of family problems, and, with them, he composes a working plan for better-functioning families. Personal contact with families before the epidemiological crisis has been replaced by remote work, replaced by changed tools, indirect contact with clients, and changing attitudes among workers. All changes have led to a transformation of daily work and organization in the workplace.
摘要本文以家庭助理为例,对远程工作对社会福利行业的影响进行了反思。网络调查的重点是随着疫情危机而出现的社会福利项目的变化,比如家庭助理。本文介绍了2020年6月使用survey Monkey在线网络调查问卷对家庭助理进行的试点网络调查研究的结论。下西里西亚(波兰地区的一部分)的家庭助理是波兰社会福利制度中的一类职业。他们受雇于社会福利中心,并在当地社区工作。助理的任务和资格与社会工作者不同。家庭助理了解家庭问题的背景,根据这些背景,他制定了一个工作计划,使家庭运转得更好。流行病学危机之前与家庭的个人接触已被远程工作、改变的工具、与客户的间接接触以及工作人员态度的变化所取代。所有这些变化都导致了工作场所日常工作和组织的转变。
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引用次数: 0
Ventilator-associated pneumonia: Epidemiological changes or disregarded bundles? 呼吸机相关性肺炎:流行病学变化还是被忽视的肺炎群?
Pub Date : 2023-01-01 DOI: 10.1515/ohe-2023-0009
Regina Frontera, Mirko Barone
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引用次数: 0
Tranexamic acid and pre-hospital trauma setting: Is everything clear by now? 氨甲环酸和院前创伤设置:现在一切都清楚了吗?
Pub Date : 2023-01-01 DOI: 10.1515/ohe-2023-0005
Regina Frontera, Mirko Barone
Abstract An early use of tranexamic acid (TXA) in polytrauma patients has long been emphasized, although several conflicting evidence make its applicability still controversial and claims debate. Several multicenter trials have been conducted and the latter appear to collide with recent evidence published in the literature. In particular, the putative effects of early prognostic and hospitalization are still far from a common recommendation. We believe conflicting evidence derives from an unproper standardization of the pre-hospital setting, where non-diversified demographic factors, such as sociodemographic ones and accessibility to resources, still play a significant and detrimental role in patients’ outcomes. Moreover, evaluation and investigation of the real benefits of TXA administration in the trauma patient according to the different settings or scenarios are required, as the availability of resources could represent a non-negligible bias that could lead to evidence too far from universal applicability and accessibility.
长期以来,人们一直强调在多发外伤患者中早期使用氨甲环酸(TXA),尽管一些相互矛盾的证据使其适用性仍然存在争议和索赔争议。已经进行了几次多中心试验,后者似乎与最近在文献中发表的证据相冲突。特别是,早期预后和住院治疗的假定效果仍远未得到普遍推荐。我们认为,相互矛盾的证据源于院前环境的不适当标准化,其中非多样化的人口因素,如社会人口因素和资源可及性,仍然在患者预后中发挥着重要而有害的作用。此外,需要根据不同的环境或情况评估和调查创伤患者给药TXA的真正益处,因为资源的可用性可能代表不可忽略的偏差,可能导致证据离普遍适用性和可及性太远。
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引用次数: 0
World Heart Day: Clinical case to raise awareness on cardiovascular disease in women 世界心脏日:临床案例以提高对妇女心血管疾病的认识
Pub Date : 2023-01-01 DOI: 10.1515/ohe-2022-0031
M. C. Sun
Abstract The World Heart Federation highlights that cardiovascular disease (CVD) is the leading cause of death in women worldwide. Indeed, women have unique female-specific risk factors for stroke, which include pregnancy, history of preeclampsia/eclampsia or gestational diabetes, duration of reproductive life, oral contraceptive use, and postmenopausal hormone therapy. In light of the female-specific risk factors and/or predisposing conditions, there is need to sensitize health professionals and the public in general on CVD in women. This clinical case is being shared with the written consent of the patient so as to avoid misdiagnosis or underdiagnosis of CVD among women.
世界心脏联合会强调,心血管疾病(CVD)是世界范围内妇女死亡的主要原因。事实上,女性有独特的女性中风风险因素,包括怀孕、先兆子痫/子痫或妊娠糖尿病史、生育年限、口服避孕药使用和绝经后激素治疗。鉴于女性特有的风险因素和/或易感条件,有必要提高卫生专业人员和公众对女性心血管疾病的认识。这一临床病例是在患者书面同意的情况下分享的,以避免误诊或漏诊妇女心血管疾病。
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引用次数: 0
Raising security of first responders with C-ITS? 用C-ITS提高急救人员的安全性?
Pub Date : 2023-01-01 DOI: 10.1515/ohe-2023-0003
Walter Seböck, Bettina Biron, Bettina Pospisil
Abstract This article recommends social science research-based recommendations for improving first responder safety and occupational health by assessing cooperative intelligent transport systems (C-ITS) for use by emergency services and law enforcement. This involves vehicles using digital technologies to inform each other or via objects such as roadworks signs about traffic situations and dangerous circumstances. The application of information and communication technologies to the road transport sector and its interfaces with other modes of transport shall make a significant contribution to improving environmental performance, efficiency, including energy efficiency, safety, and security of road transport. This article investigates which social science aspects must be considered when implementing C-ITS, so that emergency vehicles such as ambulances can be given automated priority. Since emergency vehicles can communicate with traffic signal systems or other vehicles, safety requirements play a particularly important role. This leads to the question of which challenges subjective safety and technology perceptions regarding first responders are essential for the introduction of C-ITS for first responder organizations and which factors can lead to rejection.
本文提出了基于社会科学研究的建议,通过评估应急服务和执法部门使用的协作式智能交通系统(C-ITS)来改善急救人员的安全和职业健康。这包括车辆使用数字技术相互通知,或通过道路工程标志等物体通知交通状况和危险情况。将信息和通信技术应用于道路运输部门及其与其他运输方式的接口,将对改善道路运输的环境绩效、效率、包括能源效率、安全和保障作出重大贡献。本文调查了在实施C-ITS时必须考虑的社会科学方面,以便救护车等紧急车辆可以获得自动优先权。由于应急车辆可以与交通信号系统或其他车辆进行通信,因此安全要求起着特别重要的作用。这就导致了这样一个问题,即对于第一响应者来说,哪些挑战的主观安全和技术观念对于第一响应者组织引入C-ITS至关重要,哪些因素可能导致拒绝。
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引用次数: 0
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Open health data
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