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On the Reality of Intrinsically Finkable Dispositions. 论内在可调性的真实性。
Pub Date : 2016-01-01 Epub Date: 2016-04-30 DOI: 10.1007/s11406-016-9713-z
Matthew Tugby

Recently, Choi (Noûs, 46, 289-325, 2012) has argued that current accounts of intrinsically finkable dispositions lead to absurd consequences in certain everyday cases. In this paper I offer a new argument for the existence of intrinsically finkable dispositions, one which provides a new way of testing for the presence of such dispositions. It is then argued that, with this new test in place, Choi's examples no longer present a problem for the view that some dispositions are intrinsically finkable.

最近,Choi (no s, 46,289 -325, 2012)认为,在某些日常情况下,固有可选倾向的当前账户会导致荒谬的后果。在本文中,我提出了一个关于内在可寻性的存在的新论证,它提供了一种检验这种内在可寻性是否存在的新方法。然后有人认为,有了这个新的测试,Choi的例子不再提出一些性格本质上是可选择的观点的问题。
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引用次数: 7
Two Improvements to the Intentional Stance Theory: Hutto and Satne on Naturalizing Content. 意向立场理论的两个改进:Hutto和Satne关于内容的自然化。
Pub Date : 2015-01-01 Epub Date: 2015-12-08 DOI: 10.1007/s11406-015-9627-1
Marc Slors

In this paper I assess the extent to which Daniel Dennett's Intentional Stance Theory fits into the overall proposal for a programme on naturalizing mental content outlined by Daniel Hutto and Glenda Satne in this issue (Philosophia 43, 2015). I argue that in order to fit the proposal, two changes need to be made: (1) the reality of intentional states should not (just) be grounded in the reality of behavioral patterns but in the ascription-independent status of Ur-intentionality that is the at the root of all intentionality, including content-involving intentonality. This is tricky since (i) Ur-intentionality resembles 'original intentionality', which is a notion Dennett rejects, and (ii) the ascription-dependent status of content-involving intentionality should be kept intact. (2) adopting the intentional stance is possible only as part of socio-cultural practices, which implies that this is an exclusively human capacity. I also argue that both changes to the theory are feasible and should be considered improvements relative to the original position developed by Dennett.

在这篇论文中,我评估了Daniel Dennett的意向立场理论在多大程度上符合Daniel Hutto和Glenda Satne在本期(Philosophia 432015)中概述的关于将心理内容自然化的计划的总体建议。我认为,为了符合这一建议,需要做出两个改变:(1)意向性状态的现实不应该(仅仅)建立在行为模式的现实基础上,而应该建立在你的意向性的归属独立地位上,这是所有意向性的根本,包括涉及意向性的内容。这很棘手,因为(i)你的意向性类似于“原始意向性”,这是Dennett拒绝的概念,以及(ii)涉及意向性的内容的归属依赖状态应该保持不变。(2) 只有作为社会文化实践的一部分,才有可能采取有意的立场,这意味着这是一种纯粹的人类能力。我还认为,对理论的两个修改都是可行的,应该被视为相对于Dennett提出的原始立场的改进。
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引用次数: 2
The Primacy of Skilled Intentionality: on Hutto & Satne's the Natural Origins of Content. 熟练意图的首要性——论胡图和萨顿的《内容的自然起源》。
Pub Date : 2015-01-01 Epub Date: 2015-11-21 DOI: 10.1007/s11406-015-9645-z
Julian Kiverstein, Erik Rietveld

Following a brief reconstruction of Hutto & Satne's paper we focus our critical comments on two issues. First we take up H&S's claim that a non-representational form of ur-intentionality exists that performs essential work in setting the scene for content-involving forms of intentionality. We will take issue with the characterisation that H&S give of this non-representational form of intentionality. Part of our commentary will therefore be aimed at motivating an alternative account of how there can be intentionality without mental content, which we have called skilled intentionality. Skilled intentionality is the individual's selective openness and responsiveness to a rich landscape of affordances. A second issue we take up concerns the distinction between ur-intentionality and content-involving intentionality. We will argue that our notion of skilled intentionality as it is found in humans cuts across these two categories. Instead of distinguishing between different forms of intentionality we recommend focusing on how skilled intentionality takes different forms in different forms of life.

在对Hutto和Satne的论文进行简短的重建之后,我们将重点评论两个问题。首先,我们接受H&S的说法,即存在一种非代表性的意向性形式,它在为涉及意向性形式的内容设置场景方面发挥着重要作用。我们将对H&S对这种非代表性意向性形式的描述提出异议。因此,我们的部分评论将旨在激发一种替代性的解释,即如何在没有心理内容的情况下存在意向性,我们称之为熟练意向性。熟练的意向性是个体对丰富的可供性景观的选择性开放和反应。我们讨论的第二个问题涉及我们的意向性和涉及意向性的内容之间的区别。我们会争辩说,我们在人类身上发现的熟练意向性概念跨越了这两类。与其区分不同形式的意向性,我们建议关注熟练的意向性如何在不同的生活形式中表现出不同的形式。
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引用次数: 56
Supreme Emergencies Without the Bad Guys. 没有坏人的超级紧急事件。
Pub Date : 2009-01-01 Epub Date: 2008-07-26 DOI: 10.1007/s11406-008-9145-5
Per Sandin

This paper discusses the application of the supreme emergency doctrine from just-war theory to non-antagonistic threats. Two versions of the doctrine are considered: Michael Walzer's communitarian version and Brian Orend's prudential one. I investigate first whether the doctrines are applicable to non-antagonistic threats, and second whether they are defensible. I argue that a version of Walzer's doctrine seems to be applicable to non-antagonistic threats, but that it is very doubtful whether the doctrine is defensible. I also argue that Orend's version of the doctrine is applicable to non-antagonistic threats, but that his account is not defensible, regardless of whether the threats are antagonistic or not.

本文从正义战争理论出发,探讨了最高紧急状态原则在非对抗性威胁中的应用。该学说有两个版本:Michael Walzer的社群主义版本和Brian Orend的审慎主义版本。我首先研究这些理论是否适用于非对抗性威胁,其次研究它们是否站得住脚。我认为,沃尔泽理论的一个版本似乎适用于非对抗性威胁,但该理论是否站得住是非常值得怀疑的。我还认为,奥伦德的理论版本适用于非对抗性威胁,但无论威胁是否对抗性,他的解释都是站不住脚的。
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引用次数: 17
Voluntary action 自愿行为
Pub Date : 2001-01-01 DOI: 10.1007/BF02379772
Edmund Wall
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引用次数: 0
Formation of 8-hydroxyguanine residues in DNA by X-irradiation. x射线照射下DNA中8-羟基鸟嘌呤残基的形成。
Pub Date : 1984-12-01 DOI: 10.20772/CANCERSCI1959.75.12_1037
H. Kasai, H. Tanooka, S. Nishimura
A new type of ionizing radiation-induced DNA base damage, 8-hydroxyguanine formation, was found in DNA that had been irradiated by X-rays in aqueous solution. The extent of this modification linearly increased with increase in the X-ray dose up to 40 krad. When an OH radical scavenger, ethanol, was added to the DNA solution, the hydroxylation was inhibited almost completely, suggesting that the reaction proceeds via the formation of OH radicals.
在水溶液中经x射线辐照的DNA中发现了一种新的电离辐射诱导的DNA碱基损伤,即8-羟基鸟嘌呤的形成。这种变化的程度随着x射线剂量的增加而线性增加,直至40克拉。当在DNA溶液中加入OH自由基清除剂乙醇时,氢化作用几乎完全被抑制,这表明反应是通过OH自由基的形成进行的。
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引用次数: 121
Effects of dibutyryl adenosine 3'-5' cyclic monophosphate on the ultrastructure of rat ascites hepatoma cells and on the intracellular localization of alpha-fetoprotein. 3′-5′环单磷酸二丁基腺苷对大鼠腹水肝癌细胞超微结构及甲胎蛋白细胞内定位的影响。
Pub Date : 1984-12-01 DOI: 10.20772/CANCERSCI1959.75.12_1083
M. Torii, K. Miyake, K. Kanai
The growth of rat ascites hepatoma cells (AH 66) in vitro was inhibited and the amount of alpha-fetoprotein (AFP) in the culture medium was increased in the presence of dibutyryl adenosine 3'-5' cyclic monophosphate (DBc-AMP). Electronmicroscopically, AH 66 cells that had been incubated with DBc-AMP showed an increase in polysomes on rough endoplasmic reticulum (RER), and some mitochondria appeared to be completely surrounded by RER. AFP in untreated cells was found to be localized on ribosomes of RER, free ribosomes and occasionally also on microvilli of cell membranes by electronmicroscopic and immunohistochemical analysis. After DBc-AMP treatment, increased staining of AFP was identified on ribosomes of RER and microvilli of cell membranes as well as on nuclear membranes. These results suggest that DBc-AMP accelerates the production and release of AFP in cultured rat ascites hepatoma cells.
3′-5′环单磷酸二丁基腺苷(DBc-AMP)的存在抑制了体外培养的大鼠腹水肝癌细胞(AH 66)的生长,增加了培养液中甲胎蛋白(AFP)的含量。电镜下,经DBc-AMP孵育的AH 66细胞显示粗内质网(RER)上多聚体增加,部分线粒体被粗内质网完全包围。电镜和免疫组化分析发现,未经处理的细胞中AFP定位于内质网核糖体、游离核糖体上,偶尔也定位于细胞膜微绒毛上。经DBc-AMP处理后,内质网核糖体、细胞膜微绒毛及核膜上的AFP染色增加。这些结果表明DBc-AMP能促进培养的大鼠腹水肝癌细胞中AFP的产生和释放。
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引用次数: 2
Disruptive effect of diethylstilbestrol on microtubules. 己烯雌酚对微管的破坏作用。
Pub Date : 1984-12-01 DOI: 10.20772/CANCERSCI1959.75.12_1046
Y. Sato, T. Murai, M. Tsumuraya, H. Saitŏ, M. Kodama
Diethylstilbestrol, a unique carcinogen lacking measurable mutagenic potency in Salmonella, was shown to be an inhibitor of microtubule assembly in vitro using microtubule proteins isolated from porcine brains. The effective concentration of diethylstilbestrol was 10-200 microM, as determined by viscometry, turbidity measurement, and electron microscopic analysis.
己烯雌酚是一种独特的致癌物,在沙门氏菌中缺乏可测量的诱变效力,使用从猪脑中分离的微管蛋白在体外被证明是微管组装的抑制剂。通过粘度测定、浊度测定和电镜分析,己烯雌酚的有效浓度为10-200微米。
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引用次数: 25
Gamma-irradiation induces mutation in ataxia-telangiectasia lymphoblastoid cells. γ辐照诱导共济失调毛细血管扩张性淋巴母细胞样细胞突变。
Pub Date : 1984-12-01 DOI: 10.20772/CANCERSCI1959.75.12_1040
K. Tatsumi, H. Takebe
Ataxia-telangiectasia (AT) cells are hypersensitive to the lethal effect of gamma-rays, whereas little or no gamma-ray induced mutation has been observed. In this work, exposure to gamma-rays of an Epstein-Barr virus-transformed AT lymphoblastoid cell line, GM2783, resulted in a clear dose-dependent increase of mutation for 6-thioguanine resistance.
共济失调毛细血管扩张(AT)细胞对γ射线的致死性作用高度敏感,而很少或没有观察到γ射线诱导的突变。在这项研究中,暴露于γ射线下的eb病毒转化的AT淋巴母细胞样细胞系GM2783,导致6-硫鸟嘌呤耐药性突变明显呈剂量依赖性增加。
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引用次数: 22
A novel human myelomonocytoid cell line, P39/Tsugane, derived from overt leukemia following myelodysplastic syndrome. 一种新的人骨髓单核细胞样细胞系P39/Tsugane,来源于骨髓增生异常综合征后的明显白血病。
Pub Date : 1984-12-01 DOI: 10.20772/CANCERSCI1959.75.12_1100
M. Nagai, S. Seki, T. Kitahara, T. Abe, K. Minato, S. Watanabe, M. Shimoyama
A novel human cultured cell line, P39/Tsugane, was established from leukemic cells in the peripheral blood of a 69-year-old male with overt leukemia following myelodysplastic syndrome (MDS). P39/Tsugane cells were characterized by blastic appearance, presence of NaF-sensitive alpha-naphthyl butylate esterase activity, Fc gamma-receptor, C3-receptor, capacity to phagocytize sensitized erythrocytes, and reactivity with monoclonal antibodies such as OKT4, My4, VIMD5, MCS-2 and My7. These data indicate that P39/Tsugane cells are of myelomonocytoid nature. P39/Tsugane had a hypodiploid chromosome constitution with a gain of a consistent marker, 6q+, the presence of less consistent markers 9q+ and rcp(14;16), and random and non-random losses of autosomes: in accordance with the reported cytogenetic profiles of MDS, a representative karyotype of the present cell line is 45,XY,+del(6)(q15),9q+, t(14;16)-(q24;q21),-16,-17. P39/Tsugane cells were transplantable intraperitoneally into nude mice, and produced abdominal tumors and hemorrhagic ascites. These results indicate that P39/Tsugane is the first cultured cell line of myelomonocytoid nature to be derived from overt leukemia following MDS. Therefore, P39/Tsugane cells should be useful for studies on the differentiation of leukemia cells, the pathogenesis of MDS and in vitro-in vivo experimental chemotherapy.
一种新的人类培养细胞系P39/Tsugane是从一名69岁男性骨髓增生异常综合征(MDS)后明显白血病的外周血白血病细胞中建立的。P39/Tsugane细胞的特征是胚状外观,存在naff敏感的α -萘基丁酸酯酶活性,Fc γ受体,c3受体,吞噬致敏红细胞的能力,以及与OKT4, My4, VIMD5, MCS-2和My7等单克隆抗体的反应性。这些数据表明P39/Tsugane细胞具有髓单核细胞样性质。P39/Tsugane具有次二倍体染色体结构,获得一致的标记6q+,存在不一致的标记9q+和rcp(14;16),随机和非随机丢失常染色体:根据已报道的MDS细胞遗传学谱,本细胞系的代表性核型为45,XY,+del(6)(q15),9q+, t(14;16)-(q24;q21),-16,-17。P39/Tsugane细胞可腹腔移植到裸鼠体内,产生腹腔肿瘤和出血性腹水。这些结果表明P39/Tsugane是MDS后从显性白血病中获得的第一个培养的髓单核细胞样细胞系。因此,P39/Tsugane细胞可用于白血病细胞分化、MDS发病机制及体内外实验化疗的研究。
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引用次数: 39
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Philosophia (Ramat-Gan, Israel)
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