Pub Date : 2016-01-01Epub Date: 2016-04-30DOI: 10.1007/s11406-016-9713-z
Matthew Tugby
Recently, Choi (Noûs, 46, 289-325, 2012) has argued that current accounts of intrinsically finkable dispositions lead to absurd consequences in certain everyday cases. In this paper I offer a new argument for the existence of intrinsically finkable dispositions, one which provides a new way of testing for the presence of such dispositions. It is then argued that, with this new test in place, Choi's examples no longer present a problem for the view that some dispositions are intrinsically finkable.
最近,Choi (no s, 46,289 -325, 2012)认为,在某些日常情况下,固有可选倾向的当前账户会导致荒谬的后果。在本文中,我提出了一个关于内在可寻性的存在的新论证,它提供了一种检验这种内在可寻性是否存在的新方法。然后有人认为,有了这个新的测试,Choi的例子不再提出一些性格本质上是可选择的观点的问题。
{"title":"On the Reality of Intrinsically Finkable Dispositions.","authors":"Matthew Tugby","doi":"10.1007/s11406-016-9713-z","DOIUrl":"https://doi.org/10.1007/s11406-016-9713-z","url":null,"abstract":"<p><p>Recently, Choi (<i>Noûs, 46</i>, 289-325, 2012) has argued that current accounts of intrinsically finkable dispositions lead to absurd consequences in certain everyday cases. In this paper I offer a new argument for the existence of intrinsically finkable dispositions, one which provides a new way of testing for the presence of such dispositions. It is then argued that, with this new test in place, Choi's examples no longer present a problem for the view that some dispositions are intrinsically finkable.</p>","PeriodicalId":74436,"journal":{"name":"Philosophia (Ramat-Gan, Israel)","volume":"44 2","pages":"623-631"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s11406-016-9713-z","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36441741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-01-01Epub Date: 2015-12-08DOI: 10.1007/s11406-015-9627-1
Marc Slors
In this paper I assess the extent to which Daniel Dennett's Intentional Stance Theory fits into the overall proposal for a programme on naturalizing mental content outlined by Daniel Hutto and Glenda Satne in this issue (Philosophia 43, 2015). I argue that in order to fit the proposal, two changes need to be made: (1) the reality of intentional states should not (just) be grounded in the reality of behavioral patterns but in the ascription-independent status of Ur-intentionality that is the at the root of all intentionality, including content-involving intentonality. This is tricky since (i) Ur-intentionality resembles 'original intentionality', which is a notion Dennett rejects, and (ii) the ascription-dependent status of content-involving intentionality should be kept intact. (2) adopting the intentional stance is possible only as part of socio-cultural practices, which implies that this is an exclusively human capacity. I also argue that both changes to the theory are feasible and should be considered improvements relative to the original position developed by Dennett.
{"title":"Two Improvements to the Intentional Stance Theory: Hutto and Satne on Naturalizing Content.","authors":"Marc Slors","doi":"10.1007/s11406-015-9627-1","DOIUrl":"10.1007/s11406-015-9627-1","url":null,"abstract":"<p><p>In this paper I assess the extent to which Daniel Dennett's Intentional Stance Theory fits into the overall proposal for a programme on naturalizing mental content outlined by Daniel Hutto and Glenda Satne in this issue (Philosophia 43, 2015). I argue that in order to fit the proposal, two changes need to be made: (1) the reality of intentional states should not (just) be grounded in the reality of behavioral patterns but in the ascription-independent status of Ur-intentionality that is the at the root of all intentionality, including content-involving intentonality. This is tricky since (i) Ur-intentionality resembles 'original intentionality', which is a notion Dennett rejects, and (ii) the ascription-dependent status of content-involving intentionality should be kept intact. (2) adopting the intentional stance is possible only as part of socio-cultural practices, which implies that this is an exclusively human capacity. I also argue that both changes to the theory are feasible and should be considered improvements relative to the original position developed by Dennett.</p>","PeriodicalId":74436,"journal":{"name":"Philosophia (Ramat-Gan, Israel)","volume":"43 3","pages":"579-591"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s11406-015-9627-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36441736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-01-01Epub Date: 2015-11-21DOI: 10.1007/s11406-015-9645-z
Julian Kiverstein, Erik Rietveld
Following a brief reconstruction of Hutto & Satne's paper we focus our critical comments on two issues. First we take up H&S's claim that a non-representational form of ur-intentionality exists that performs essential work in setting the scene for content-involving forms of intentionality. We will take issue with the characterisation that H&S give of this non-representational form of intentionality. Part of our commentary will therefore be aimed at motivating an alternative account of how there can be intentionality without mental content, which we have called skilled intentionality. Skilled intentionality is the individual's selective openness and responsiveness to a rich landscape of affordances. A second issue we take up concerns the distinction between ur-intentionality and content-involving intentionality. We will argue that our notion of skilled intentionality as it is found in humans cuts across these two categories. Instead of distinguishing between different forms of intentionality we recommend focusing on how skilled intentionality takes different forms in different forms of life.
{"title":"The Primacy of Skilled Intentionality: on Hutto & Satne's the Natural Origins of Content.","authors":"Julian Kiverstein, Erik Rietveld","doi":"10.1007/s11406-015-9645-z","DOIUrl":"10.1007/s11406-015-9645-z","url":null,"abstract":"<p><p>Following a brief reconstruction of Hutto & Satne's paper we focus our critical comments on two issues. First we take up H&S's claim that a non-representational form of ur-intentionality exists that performs essential work in setting the scene for content-involving forms of intentionality. We will take issue with the characterisation that H&S give of this non-representational form of intentionality. Part of our commentary will therefore be aimed at motivating an alternative account of how there can be intentionality without mental content, which we have called skilled intentionality. Skilled intentionality is the individual's selective openness and responsiveness to a rich landscape of affordances. A second issue we take up concerns the distinction between ur-intentionality and content-involving intentionality. We will argue that our notion of skilled intentionality as it is found in humans cuts across these two categories. Instead of distinguishing between different forms of intentionality we recommend focusing on how skilled intentionality takes different forms in different forms of life.</p>","PeriodicalId":74436,"journal":{"name":"Philosophia (Ramat-Gan, Israel)","volume":"43 3","pages":"701-721"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s11406-015-9645-z","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36441737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2009-01-01Epub Date: 2008-07-26DOI: 10.1007/s11406-008-9145-5
Per Sandin
This paper discusses the application of the supreme emergency doctrine from just-war theory to non-antagonistic threats. Two versions of the doctrine are considered: Michael Walzer's communitarian version and Brian Orend's prudential one. I investigate first whether the doctrines are applicable to non-antagonistic threats, and second whether they are defensible. I argue that a version of Walzer's doctrine seems to be applicable to non-antagonistic threats, but that it is very doubtful whether the doctrine is defensible. I also argue that Orend's version of the doctrine is applicable to non-antagonistic threats, but that his account is not defensible, regardless of whether the threats are antagonistic or not.
{"title":"Supreme Emergencies Without the Bad Guys.","authors":"Per Sandin","doi":"10.1007/s11406-008-9145-5","DOIUrl":"https://doi.org/10.1007/s11406-008-9145-5","url":null,"abstract":"<p><p>This paper discusses the application of the supreme emergency doctrine from just-war theory to non-antagonistic threats. Two versions of the doctrine are considered: Michael Walzer's communitarian version and Brian Orend's prudential one. I investigate first whether the doctrines are applicable to non-antagonistic threats, and second whether they are defensible. I argue that a version of Walzer's doctrine seems to be applicable to non-antagonistic threats, but that it is very doubtful whether the doctrine is defensible. I also argue that Orend's version of the doctrine is applicable to non-antagonistic threats, but that his account is not defensible, regardless of whether the threats are antagonistic or not.</p>","PeriodicalId":74436,"journal":{"name":"Philosophia (Ramat-Gan, Israel)","volume":"37 1","pages":"153-167"},"PeriodicalIF":0.0,"publicationDate":"2009-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s11406-008-9145-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37772940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1984-12-01DOI: 10.20772/CANCERSCI1959.75.12_1037
H. Kasai, H. Tanooka, S. Nishimura
A new type of ionizing radiation-induced DNA base damage, 8-hydroxyguanine formation, was found in DNA that had been irradiated by X-rays in aqueous solution. The extent of this modification linearly increased with increase in the X-ray dose up to 40 krad. When an OH radical scavenger, ethanol, was added to the DNA solution, the hydroxylation was inhibited almost completely, suggesting that the reaction proceeds via the formation of OH radicals.
{"title":"Formation of 8-hydroxyguanine residues in DNA by X-irradiation.","authors":"H. Kasai, H. Tanooka, S. Nishimura","doi":"10.20772/CANCERSCI1959.75.12_1037","DOIUrl":"https://doi.org/10.20772/CANCERSCI1959.75.12_1037","url":null,"abstract":"A new type of ionizing radiation-induced DNA base damage, 8-hydroxyguanine formation, was found in DNA that had been irradiated by X-rays in aqueous solution. The extent of this modification linearly increased with increase in the X-ray dose up to 40 krad. When an OH radical scavenger, ethanol, was added to the DNA solution, the hydroxylation was inhibited almost completely, suggesting that the reaction proceeds via the formation of OH radicals.","PeriodicalId":74436,"journal":{"name":"Philosophia (Ramat-Gan, Israel)","volume":"30 1","pages":"1037-9"},"PeriodicalIF":0.0,"publicationDate":"1984-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81672926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1984-12-01DOI: 10.20772/CANCERSCI1959.75.12_1083
M. Torii, K. Miyake, K. Kanai
The growth of rat ascites hepatoma cells (AH 66) in vitro was inhibited and the amount of alpha-fetoprotein (AFP) in the culture medium was increased in the presence of dibutyryl adenosine 3'-5' cyclic monophosphate (DBc-AMP). Electronmicroscopically, AH 66 cells that had been incubated with DBc-AMP showed an increase in polysomes on rough endoplasmic reticulum (RER), and some mitochondria appeared to be completely surrounded by RER. AFP in untreated cells was found to be localized on ribosomes of RER, free ribosomes and occasionally also on microvilli of cell membranes by electronmicroscopic and immunohistochemical analysis. After DBc-AMP treatment, increased staining of AFP was identified on ribosomes of RER and microvilli of cell membranes as well as on nuclear membranes. These results suggest that DBc-AMP accelerates the production and release of AFP in cultured rat ascites hepatoma cells.
{"title":"Effects of dibutyryl adenosine 3'-5' cyclic monophosphate on the ultrastructure of rat ascites hepatoma cells and on the intracellular localization of alpha-fetoprotein.","authors":"M. Torii, K. Miyake, K. Kanai","doi":"10.20772/CANCERSCI1959.75.12_1083","DOIUrl":"https://doi.org/10.20772/CANCERSCI1959.75.12_1083","url":null,"abstract":"The growth of rat ascites hepatoma cells (AH 66) in vitro was inhibited and the amount of alpha-fetoprotein (AFP) in the culture medium was increased in the presence of dibutyryl adenosine 3'-5' cyclic monophosphate (DBc-AMP). Electronmicroscopically, AH 66 cells that had been incubated with DBc-AMP showed an increase in polysomes on rough endoplasmic reticulum (RER), and some mitochondria appeared to be completely surrounded by RER. AFP in untreated cells was found to be localized on ribosomes of RER, free ribosomes and occasionally also on microvilli of cell membranes by electronmicroscopic and immunohistochemical analysis. After DBc-AMP treatment, increased staining of AFP was identified on ribosomes of RER and microvilli of cell membranes as well as on nuclear membranes. These results suggest that DBc-AMP accelerates the production and release of AFP in cultured rat ascites hepatoma cells.","PeriodicalId":74436,"journal":{"name":"Philosophia (Ramat-Gan, Israel)","volume":"3 1","pages":"1083-8"},"PeriodicalIF":0.0,"publicationDate":"1984-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82644255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1984-12-01DOI: 10.20772/CANCERSCI1959.75.12_1046
Y. Sato, T. Murai, M. Tsumuraya, H. Saitŏ, M. Kodama
Diethylstilbestrol, a unique carcinogen lacking measurable mutagenic potency in Salmonella, was shown to be an inhibitor of microtubule assembly in vitro using microtubule proteins isolated from porcine brains. The effective concentration of diethylstilbestrol was 10-200 microM, as determined by viscometry, turbidity measurement, and electron microscopic analysis.
{"title":"Disruptive effect of diethylstilbestrol on microtubules.","authors":"Y. Sato, T. Murai, M. Tsumuraya, H. Saitŏ, M. Kodama","doi":"10.20772/CANCERSCI1959.75.12_1046","DOIUrl":"https://doi.org/10.20772/CANCERSCI1959.75.12_1046","url":null,"abstract":"Diethylstilbestrol, a unique carcinogen lacking measurable mutagenic potency in Salmonella, was shown to be an inhibitor of microtubule assembly in vitro using microtubule proteins isolated from porcine brains. The effective concentration of diethylstilbestrol was 10-200 microM, as determined by viscometry, turbidity measurement, and electron microscopic analysis.","PeriodicalId":74436,"journal":{"name":"Philosophia (Ramat-Gan, Israel)","volume":"93 1","pages":"1046-8"},"PeriodicalIF":0.0,"publicationDate":"1984-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88530302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1984-12-01DOI: 10.20772/CANCERSCI1959.75.12_1040
K. Tatsumi, H. Takebe
Ataxia-telangiectasia (AT) cells are hypersensitive to the lethal effect of gamma-rays, whereas little or no gamma-ray induced mutation has been observed. In this work, exposure to gamma-rays of an Epstein-Barr virus-transformed AT lymphoblastoid cell line, GM2783, resulted in a clear dose-dependent increase of mutation for 6-thioguanine resistance.
{"title":"Gamma-irradiation induces mutation in ataxia-telangiectasia lymphoblastoid cells.","authors":"K. Tatsumi, H. Takebe","doi":"10.20772/CANCERSCI1959.75.12_1040","DOIUrl":"https://doi.org/10.20772/CANCERSCI1959.75.12_1040","url":null,"abstract":"Ataxia-telangiectasia (AT) cells are hypersensitive to the lethal effect of gamma-rays, whereas little or no gamma-ray induced mutation has been observed. In this work, exposure to gamma-rays of an Epstein-Barr virus-transformed AT lymphoblastoid cell line, GM2783, resulted in a clear dose-dependent increase of mutation for 6-thioguanine resistance.","PeriodicalId":74436,"journal":{"name":"Philosophia (Ramat-Gan, Israel)","volume":"16 1","pages":"1040-3"},"PeriodicalIF":0.0,"publicationDate":"1984-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87323490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1984-12-01DOI: 10.20772/CANCERSCI1959.75.12_1100
M. Nagai, S. Seki, T. Kitahara, T. Abe, K. Minato, S. Watanabe, M. Shimoyama
A novel human cultured cell line, P39/Tsugane, was established from leukemic cells in the peripheral blood of a 69-year-old male with overt leukemia following myelodysplastic syndrome (MDS). P39/Tsugane cells were characterized by blastic appearance, presence of NaF-sensitive alpha-naphthyl butylate esterase activity, Fc gamma-receptor, C3-receptor, capacity to phagocytize sensitized erythrocytes, and reactivity with monoclonal antibodies such as OKT4, My4, VIMD5, MCS-2 and My7. These data indicate that P39/Tsugane cells are of myelomonocytoid nature. P39/Tsugane had a hypodiploid chromosome constitution with a gain of a consistent marker, 6q+, the presence of less consistent markers 9q+ and rcp(14;16), and random and non-random losses of autosomes: in accordance with the reported cytogenetic profiles of MDS, a representative karyotype of the present cell line is 45,XY,+del(6)(q15),9q+, t(14;16)-(q24;q21),-16,-17. P39/Tsugane cells were transplantable intraperitoneally into nude mice, and produced abdominal tumors and hemorrhagic ascites. These results indicate that P39/Tsugane is the first cultured cell line of myelomonocytoid nature to be derived from overt leukemia following MDS. Therefore, P39/Tsugane cells should be useful for studies on the differentiation of leukemia cells, the pathogenesis of MDS and in vitro-in vivo experimental chemotherapy.
{"title":"A novel human myelomonocytoid cell line, P39/Tsugane, derived from overt leukemia following myelodysplastic syndrome.","authors":"M. Nagai, S. Seki, T. Kitahara, T. Abe, K. Minato, S. Watanabe, M. Shimoyama","doi":"10.20772/CANCERSCI1959.75.12_1100","DOIUrl":"https://doi.org/10.20772/CANCERSCI1959.75.12_1100","url":null,"abstract":"A novel human cultured cell line, P39/Tsugane, was established from leukemic cells in the peripheral blood of a 69-year-old male with overt leukemia following myelodysplastic syndrome (MDS). P39/Tsugane cells were characterized by blastic appearance, presence of NaF-sensitive alpha-naphthyl butylate esterase activity, Fc gamma-receptor, C3-receptor, capacity to phagocytize sensitized erythrocytes, and reactivity with monoclonal antibodies such as OKT4, My4, VIMD5, MCS-2 and My7. These data indicate that P39/Tsugane cells are of myelomonocytoid nature. P39/Tsugane had a hypodiploid chromosome constitution with a gain of a consistent marker, 6q+, the presence of less consistent markers 9q+ and rcp(14;16), and random and non-random losses of autosomes: in accordance with the reported cytogenetic profiles of MDS, a representative karyotype of the present cell line is 45,XY,+del(6)(q15),9q+, t(14;16)-(q24;q21),-16,-17. P39/Tsugane cells were transplantable intraperitoneally into nude mice, and produced abdominal tumors and hemorrhagic ascites. These results indicate that P39/Tsugane is the first cultured cell line of myelomonocytoid nature to be derived from overt leukemia following MDS. Therefore, P39/Tsugane cells should be useful for studies on the differentiation of leukemia cells, the pathogenesis of MDS and in vitro-in vivo experimental chemotherapy.","PeriodicalId":74436,"journal":{"name":"Philosophia (Ramat-Gan, Israel)","volume":"121 1","pages":"1100-7"},"PeriodicalIF":0.0,"publicationDate":"1984-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90575302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}