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Vitamin C and glutathione supplementation: a review of their additive effects on exercise performance. 补充维生素C和谷胱甘肽:综述它们对运动性能的相加作用。
Pub Date : 2023-09-01 Epub Date: 2023-09-30 DOI: 10.20463/pan.2023.0027
Eunjoo Lee, Hun-Young Park, Sung-Woo Kim, Jisu Kim, Kiwon Lim

Purpose: This review aimed to investigate the effects of vitamin C and glutathione supplementation on exercise performance.

Methods: We conducted a literature search across the PubMed, Google Scholar, and Web of Science databases using the keywords vitamin C, glutathione, antioxidants, exercise, and oxidative stress.

Results: The effects of vitamin C supplementation on exercise performance and oxidative stress levels are inconsistent. Glutathione, with its diverse forms of supplementation and methods, presents mixed outcomes. Vitamin C and glutathione have deeply interconnected antioxidant functions and are mutually essential to each other. Research investigating the combined intake of these two substances, which are intricately linked biochemically, and their effects on exercise performance remain largely unexplored.

Conclusion: Studies on the effects of vitamin C and glutathione intake on exercise have been conducted using diverse approaches; however, the results have not been consistent. Although an additive effect is anticipated with the combined intake of vitamin C and glutathione, research on this topic is currently insufficient, and further studies are required.

目的:本综述旨在探讨补充维生素C和谷胱甘肽对运动成绩的影响。方法:我们在PubMed、Google Scholar和Web of Science数据库中使用关键词维生素C、谷胱甘肽、抗氧化剂、运动和氧化应激进行了文献搜索。结果:补充维生素C对运动表现和氧化应激水平的影响是不一致的。谷胱甘肽的补充形式和方法多种多样,结果喜忧参半。维生素C和谷胱甘肽具有深刻的相互关联的抗氧化功能,并且相互必不可少。这两种物质在生物化学上有着错综复杂的联系,研究它们的联合摄入及其对运动表现的影响在很大程度上尚未被探索。结论:采用多种方法研究了维生素C和谷胱甘肽摄入对运动的影响;然而,结果并不一致。尽管维生素C和谷胱甘肽的联合摄入预计会产生相加效应,但目前对这一主题的研究还不够,还需要进一步的研究。
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引用次数: 0
Analytical parameters to check association between load carriage system and bag packs-influenced musculoskeletal complications among school going students: a scoping review. 检查承载系统和书包之间关系的分析参数影响在校学生的肌肉骨骼并发症:范围界定综述。
Pub Date : 2023-09-01 Epub Date: 2023-09-30 DOI: 10.20463/pan.2023.0025
Mahima Guleria, Shashi Prakash Sharma, Amit Kumar

Purpose: This study aimed to investigate the correlation between load-carriage systems and backpacks on musculoskeletal complications among school-going students. Additionally, the purpose was to identify research gaps and provide recommendations for future research.

Methods: To conduct this study, we conducted a thorough search of five databases for literature published between January 2010 and December 2022. Our focus was on original published articles that reported musculoskeletal complications using analytical parameters or outcome measures among school-going students. Two reviewers independently extracted data for eligibility. The studies selected for the analysis focused on musculoskeletal complications and the outcome measures to report these complications.

Results: A total of 3541 titles were screened; of which, 18 observational studies were included. The musculoskeletal complications identified in these studies included lower back, shoulder, and neck pain and disturbed posture. Overall, the quality of the reporting in these studies was deemed satisfactory.

Conclusion: Our analysis revealed that pain and postural abnormalities were the most frequently reported complications. Hence, we recommend that future studies incorporate multiple evaluations rather than concentrating on a single symptom.

目的:本研究旨在调查负重系统和背包对在校学生肌肉骨骼并发症的影响。此外,目的是找出研究差距,并为未来的研究提供建议。方法:为了进行这项研究,我们对2010年1月至2022年12月期间发表的五个文献数据库进行了彻底搜索。我们的重点是使用分析参数或结果测量报告在校学生肌肉骨骼并发症的原始发表文章。两名评审员独立提取了资格数据。选择用于分析的研究侧重于肌肉骨骼并发症和报告这些并发症的结果措施。结果:共筛选标题3541个;其中包括18项观察性研究。这些研究中发现的肌肉骨骼并发症包括下背部、肩部和颈部疼痛以及姿势紊乱。总体而言,这些研究的报告质量令人满意。结论:我们的分析显示,疼痛和姿势异常是最常见的并发症。因此,我们建议未来的研究结合多种评估,而不是集中在单一症状上。
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引用次数: 0
Effect of exercise intervention using mobile healthcare on blood lipid level and health-related physical fitness in obese women: a randomized controlled trial. 使用移动医疗保健的运动干预对肥胖女性血脂水平和健康相关体质的影响:一项随机对照试验。
Pub Date : 2023-09-01 Epub Date: 2023-09-30 DOI: 10.20463/pan.2023.0030
Jae-Ho Choi, Hun-Young Park, Yerin Sun, Jisoo Seo, Eunjoo Lee, Sung-Woo Kim, Jisu Kim, Kiwon Lim

Purpose: This study aimed to evaluate the effects of 12 weeks of non-face-to-face exercise intervention using mobile health (mHealth) on blood lipid levels and health-related physical fitness in obese women.

Methods: Thirty obese women (aged: 39.40 ± 11.07 years, percent body fat: 37.05 ± 5.15%) were enrolled, and all completed the study. Non-face-to-face exercises were performed for 12 weeks using a mHealth and smart tracker (Charge 4, Fitbit, USA). Participants were randomly assigned to an experimental (EXP) or control (CON) group. The 12-week exercise program using mHealth included resistance (twice a week for 60 min), aerobics (five times a week for 50 min), and flexibility (five times a week for 10 min).

Results: The results showed that high-density lipoprotein cholesterol (Post - Pre: 9.07 mg·dL-1, p < 0.001) and ratio of low-density to high-density lipoprotein cholesterol (Post - Pre: -0.71 mg·dL-1, p < 0.05) significantly changed during the intervention period in EXP. There were significant increases in sit-ups (Post - Pre: 7.73 numbers, p < 0.001), grip strength (Post - Pre: 2.92 kg, p < 0.001), and sit and reach (Post - Pre: 2.51 cm, p < 0.01) in EXP.

Conclusion: Non-face-to-face exercise using mHealth for 12 weeks improved blood lipid levels and health-related physical fitness; therefore, it can help improve compliance through self-monitoring and lifestyle changes by increasing physical activity.

目的:本研究旨在评估使用移动健康(mHealth)进行12周非面对面运动干预对肥胖女性血脂水平和健康相关体质的影响。方法:选择30名肥胖女性(年龄:39.40±11.07岁,体脂百分比:37.05±5.15%),全部完成研究。使用mHealth和智能追踪器(Charge 4,Fitbit,USA)进行12周的非面对面锻炼。参与者被随机分配到实验组(EXP)或对照组(CON)。使用mHealth的12周锻炼计划包括阻力(每周两次,持续60分钟)、有氧运动(每周五次,持续50分钟)、,结果:EXP干预期间,高密度脂蛋白胆固醇(前-后:9.07mg·dL-1,p<0.001)和低密度脂蛋白与高密度脂素胆固醇之比(前-前:-0.71mg·dL-1,p<0.05)发生显著变化。EXP中仰卧起坐(术后-术前:7.73个数字,p<0.001)、握力(术前:2.92 kg,p<001)和坐伸(术前后:2.51 cm,p<0.01)显著增加。结论:使用mHealth进行12周的非面对面运动可改善血脂水平和健康相关的身体素质;因此,它可以通过自我监测和通过增加体育活动改变生活方式来帮助提高依从性。
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引用次数: 0
Physical exercise-intervention can be valuable therapy for COVID-19 confinement and post-COVID-19 periods. 体育锻炼干预可能是新冠肺炎分娩期和新冠肺炎后有价值的治疗方法。
Pub Date : 2023-09-01 Epub Date: 2023-09-30 DOI: 10.20463/pan.2023.0024
Yi-Sub Kwak, Kiyun Han, Jaeeun Lee, Jongnam Kim

Purpose: The COVID-19 pandemic and its transition into an endemic phase have profoundly impacted physical health, well-being, mental health, education, and various aspects of society, including the economy and social networks. Home confinement, social distancing, and physical inactivity have exacerbated numerous health issues, including obesity, diabetes mellitus, hypertension, hyperlipidemia, cardiovascular diseases, depression, and poor sleep quality. A systematic review has revealed significant findings: Regular aerobic programs (such as cycling or walking at an intensity of 60-80% of HR max for 20-60 minutes per session, repeated 2-3 times a week) have proven effective in improving both physical and mental health, as well as immune function. This type of physical activity has been shown to increase immunological markers, including lymphocytes, leukocytes, neutrophils, monocytes, and interleukin-6 (IL-6), while reducing low-grade inflammation. Therefore, in this study we aimed to assess the impact of tailored exercise interventions on the physical and mental health of COVID-19 patients. Based on the results, we can establish exercise intervention strategies to mitigate the negative health consequences during and after the COVID-19 pandemic.

Methods: We conducted a search of the PubMed database from January 2020 to August 2023 using predefined search terms such as "COVID-19 and post-COVID-19," "exercise intervention and immunity," and "mental health." By examining references, we explored the links between exercise interventions and the mental and physical health of COVID-19 patients.

Results: A tailored, multifaceted exercise intervention should be developed and implemented to address the existing mental challenges and enhance mental health during both the pandemic and the post-COVID-19 periods.

Conclusion: Breathing exercises and respiratory support techniques, including yoga, thoracic expansion exercises, airway clearance methods, and breathing control, are likely to be beneficial.

目的:新冠肺炎大流行及其向流行阶段的过渡对身体健康、福祉、心理健康、教育和社会各个方面,包括经济和社会网络产生了深远影响。家庭禁闭、保持社交距离和缺乏体育锻炼加剧了许多健康问题,包括肥胖、糖尿病、高血压、高脂血症、心血管疾病、抑郁症和睡眠质量差。一项系统综述揭示了重要的发现:有规律的有氧运动(如以最大心率的60-80%的强度骑自行车或步行,每次20-60分钟,每周重复2-3次)已被证明对改善身心健康和免疫功能有效。这种类型的体育活动已被证明可以增加免疫标志物,包括淋巴细胞、白细胞、中性粒细胞、单核细胞和白细胞介素-6(IL-6),同时减少低度炎症。因此,在本研究中,我们旨在评估量身定制的锻炼干预措施对新冠肺炎患者身心健康的影响。根据研究结果,我们可以制定运动干预策略,以减轻新冠肺炎大流行期间和之后对健康的负面影响。方法:从2020年1月到2023年8月,我们使用预先定义的搜索词,如“新冠肺炎和新冠肺炎后”、“运动干预和免疫”和“心理健康”,对PubMed数据库进行了搜索。通过查阅参考文献,我们探索了运动干预与新冠肺炎患者身心健康之间的联系。结果:应制定和实施量身定制的多方面运动干预措施,以应对现有的心理挑战,并在大流行期间和新冠肺炎疫情后时期加强心理健康。结论:呼吸练习和呼吸支持技术,包括瑜伽、扩胸练习、气道清除方法和呼吸控制,可能是有益的。
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引用次数: 0
Prenatal physical activity and the gut microbiota of pregnant women: results from a preliminary investigation. 产前体育活动和孕妇肠道微生物群:初步调查结果。
Pub Date : 2023-06-01 DOI: 10.20463/pan.2023.0011
Sara Santarossa, Alexandra R Sitarik, Andrea E Cassidy-Bushrow, Sarah S Comstock
[Purpose] To determine whether physical activity (PA), specifically meeting the recommended 150 minutes of moderate-intensity PA per week, is associated with gut microbiota composition in pregnant women. [Methods] In an ongoing birth cohort study, questions from the Behavioral Risk Factor Surveillance System, which provides data on PA variables, were used to determine whether pregnant women met or exceeded the PA recommendations. To profile the composition of gut bacterial microbiota, 16S rRNA sequencing was performed on stool samples obtained from pregnant women. Differences in alpha diversity metrics (richness, Pielou’s evenness, and Shannon’s diversity) according to PA were determined using linear regression, whereas beta diversity relationships (Canberra and Bray-Curtis) were assessed using Permutational multivariate analysis of variance (PERMANOVA). Differences in relative taxon abundance were determined using DESeq2. [Results] The complete analytical sample included 23 women that were evaluated for both PA and 16S rRNA sequencing data (median age [Q1; Q3] = 30.5 [26.6; 34.0] years; 17.4% Black), and 11 (47.8%) met or exceeded the PA recommendations. Meeting or exceeding the PA recommendations during pregnancy was not associated with gut microbiota richness, evenness, or diversity, but it was related to distinct bacterial composition using both Canberra (p = 0.005) and Bray-Curtis (p = 0.022) distances. Significantly lower abundances of Bacteroidales, Bifidobacteriaceae, Lactobacillaceae, and Streptococcaceae were observed in women who met or exceeded the PA recommendations (all false discovery rates adjusted, p < 0.02). [Conclusion] Pregnant women who met or exceeded the PA recommendations showed altered gut microbiota composition. This study forms the basis for future studies on the impact of PA on gut microbiota during pregnancy.
目的:确定孕妇的身体活动(PA),特别是达到推荐的每周150分钟中等强度的PA,是否与肠道微生物群组成有关。方法:在一项正在进行的出生队列研究中,来自行为风险因素监测系统的问题(该系统提供了PA变量的数据)被用来确定孕妇是否达到或超过了PA建议。为了分析肠道细菌微生物群的组成,对孕妇的粪便样本进行了16S rRNA测序。采用线性回归方法确定了PA的α多样性指标(丰富度、Pielou均匀度和Shannon多样性)的差异,而β多样性关系(堪培拉和布雷-柯蒂斯)采用多变量方差分析(Permutational multivariate analysis of variance, PERMANOVA)进行了评估。利用DESeq2测定相对分类群丰度的差异。结果:完整的分析样本包括23名女性,对其PA和16S rRNA测序数据进行了评估(中位年龄[Q1;Q3] = 30.5 [26.6;34.0)年;17.4%黑人),11人(47.8%)达到或超过了PA的建议。怀孕期间达到或超过PA推荐值与肠道菌群丰富度、均匀度或多样性无关,但与堪培拉(p = 0.005)和布雷-柯蒂斯(p = 0.022)距离的不同细菌组成有关。在达到或超过PA推荐值的女性中,观察到显着较低的拟杆菌科、双歧杆菌科、乳酸杆菌科和链球菌科丰度(调整所有错误发现率,p <0.02)。结论:达到或超过PA推荐量的孕妇肠道菌群组成发生改变。本研究为进一步研究PA对妊娠期肠道菌群的影响奠定了基础。
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引用次数: 0
Effects of exercise intensity on the reactive astrocyte polarization in the medial prefrontal cortex. 运动强度对内侧前额叶皮层星形细胞反应性极化的影响。
Pub Date : 2023-06-01 DOI: 10.20463/pan.2023.0014
Su-Ju Eo, Yea-Hyun Leem

Purpose: Physical exercise contributes to neuroplasticity by promoting cognitive functions, such as learning and memory. The astrocytic phenotype is closely associated with synaptic plasticity. This study aimed to determine whether astrocyte polarization and synaptic alterations in the medial prefrontal cortex (mPFC) are affected differently by high- and moderate-intensity exercise.

Methods: Mice were subjected to moderate-(MIE) and high-intensity treadmill running (HIE). Memory capacity was assessed using the novel object recognition and modified Y-maze tests. For immunohistochemistry, c-Fos-positive cells were counted in the mPFC. Using western blot analysis, astrocyte phenotype markers were quantified in whole-cell lysates, and synaptic molecules were determined in the synaptosomal fraction.

Results: Exercise lengthened the approach time to novel objects regardless of intensity in the NOR test, whereas MIE only improved spatial memory. Exercise induced c-Fos expression in the anterior cingulate cortex (ACC) and c-Fos-positive cells were higher in MIE than in HIE in the ACC area. In the prelimbic/infralimbic cortex region, the number of c-Fos-positive cells were enhanced in MIE and decreased in HIE mice. The A1 astrocyte marker (C3) was increased in HIE mice, while the A2 astrocyte markers were enhanced in exercised mice, regardless of the intensity. In the synaptosomal fraction, synaptic proteins were elevated by exercise regardless of intensity.

Conclusion: These results suggest that exercise intensity affects neuronal plasticity by modulating the reactive state of astrocytes in the mPFC.

目的:体育锻炼通过促进认知功能,如学习和记忆,有助于神经可塑性。星形细胞表型与突触可塑性密切相关。本研究旨在确定高强度和中等强度运动对内侧前额叶皮层(mPFC)星形胶质细胞极化和突触改变的影响是否不同。方法:小鼠进行中强度(MIE)和高强度跑步机运动(HIE)。记忆容量评估采用新的目标识别和改进的y迷宫测试。免疫组化,在mPFC中计数c- fos阳性细胞。使用western blot分析,在全细胞裂解物中定量星形胶质细胞表型标记物,并在突触体部分中测定突触分子。结果:在NOR测试中,无论运动强度如何,运动都延长了对新物体的接近时间,而MIE仅改善了空间记忆。运动诱导的c-Fos在前扣带皮层(ACC)和c-Fos阳性细胞中的表达在MIE中高于HIE中。在边缘前/边缘下皮质区,c- fos阳性细胞数量在MIE小鼠中增加,在HIE小鼠中减少。HIE小鼠的A1星形胶质细胞标记物(C3)增加,而运动小鼠的A2星形胶质细胞标记物增强,无论强度如何。在突触体部分,无论运动强度如何,突触蛋白均升高。结论:运动强度通过调节星形胶质细胞的反应状态影响神经元的可塑性。
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引用次数: 1
Running exercise and food restriction affect bone chemical properties in young female rats. 跑步运动和食物限制影响年轻雌性大鼠的骨化学特性。
Pub Date : 2023-06-01 DOI: 10.20463/pan.2023.0019
Yuki Aikawa, Yuich Noma, Umon Agata, Yuya Kakutani, Satoshi Hattori, Hitomi Ogata, Ken Kiyono, Naomi Omi

Purpose: To investigate the effects of a combination of running and food restriction on the chemical properties of the bone in young female rats using Raman spectroscopy. Furthermore, we investigated whether the chemical property parameters correlated with the bone-breaking strength.

Methods: Female Sprague-Dawley rats (7 weeks old) were randomly divided into four groups: sedentary and ad libitum feeding (SED, n = 8), voluntary running exercise and ad libitum feeding (EX, n = 8), sedentary and 30% food-restricted (SED-FR, n = 8), and voluntary running exercise and 30% food-restricted (EXFR, n = 8). The experiment was conducted for a period of 12 weeks. Four parameters measured by Raman spectroscopy were used to evaluate the bone chemical quality.

Results: Exercise and restriction had significant interactions on the mineral to matrix ratio. The mineral- to-matrix ratio in the SED-FR group was significantly higher than that in the SED group and significantly lower in the EX-FR group than that in the SED-FR group. Running exercise had significant effects on increasing the crystallinity and carbonate-to-phosphate ratio. In the ad libitum intake condition, there were significant positive correlations between breaking energy and crystallinity (r = 0.593) and between breaking energy and carbonate-to-phosphate ratio (r = 0.854).

Conclusion: Our findings show that running exercise and food restriction, alone or in combination, affect the chemical properties of bone. Furthermore, under ad libitum intake conditions, positive correlations were found between the breaking energy and crystallinity, or carbonate-to-phosphate ratio.

目的:用拉曼光谱法研究跑步和禁食对年轻雌性大鼠骨骼化学性质的影响。此外,我们还研究了化学性质参数是否与断骨强度相关。方法:雌性Sprague-Dawley大鼠(7周龄)随机分为4组:久坐自由摄食组(SED, n = 8)、自主跑步运动和自由摄食组(EX, n = 8)、久坐30%限食组(SED- fr, n = 8)、自主跑步运动30%限食组(EXFR, n = 8),实验时间为12周。用拉曼光谱测定的4个参数评价骨化学质量。结果:运动和限制对矿物质基质比有显著的相互作用。SED- fr组矿物基质比显著高于SED组,EX-FR组显著低于SED- fr组。跑步运动对提高结晶度和碳酸盐-磷酸盐比有显著作用。在自由采食条件下,破碎能与结晶度呈显著正相关(r = 0.593),破碎能与碳酸磷比呈显著正相关(r = 0.854)。结论:我们的研究结果表明,跑步运动和食物限制,单独或联合,都会影响骨骼的化学性质。此外,在任意进料条件下,破碎能与结晶度或碳酸盐-磷酸盐比呈正相关。
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引用次数: 0
Exogenous lactate intake immediately after endurance exercise increases time to exhaustion in VO2max measurements in mice. 耐力运动后立即摄入外源性乳酸增加了小鼠VO2max测量的疲劳时间。
Pub Date : 2023-06-01 DOI: 10.20463/pan.2023.0013
Sunghwan Kyun, Jisu Kim, Deunsol Hwang, Inkwon Jang, Jeehee Choi, Jongwon Kim, Won-Sang Jung, Hyejung Hwang, Sung-Woo Kim, Jeeyoung Kim, Kyunghwa Jung, Jisoo Seo, Yerin Sun, Hun-Young Park, Kiwon Lim

Purpose: The purpose of the study was to investigate the effects of 4 weeks of lactate intake immediately after endurance exercise on maximal oxygen uptake (VO2max) in exercise performance.

Methods: Seven-week-old mice from the Institute of Cancer Research (ICR) were randomly divided into four groups: vehicle intake (SE/CON), lactate intake (SE/LAC), endurance exercise with vehicle intake (EX/ CON), and lactate intake with endurance exercise (EX/ LAC). Mice were subjected to 60-70% VO2max endurance exercise with or without oral lactate intake 5 days/ week for 4 weeks. VO2max measurements (VO2max, time to exhaustion (TTE), respiratory exchange rate, fat oxidation, and carbohydrate oxidation) were recorded at the end of the study period. After 48 h of VO2max measurement, the mice were sacrificed, and three different abdominal fat samples (epididymal, perirenal, and mesenteric) were collected.

Results: Body weight and abdominal fat mass did not differ between the groups. When measuring VO2max, endurance exercise raised VO2max, and lactate intake after endurance exercise increased TTE. The change in energy substrate utilization during VO2max measurement demonstrated that although the respiratory exchange rate and fat oxidation were enhanced by lactate intake, there were no synergistic effects of lactate intake and endurance exercise.

Conclusion: Lactate intake immediately after endurance exercises can improve exercise performance, indicating the benefit of long-term exogenous lactate intake as an exercise supplement.

目的:本研究旨在探讨耐力运动后立即摄入4周乳酸对运动表现中最大摄氧量(VO2max)的影响。方法:美国癌症研究所(ICR) 7周龄小鼠随机分为4组:车辆摄食组(SE/CON)、乳酸摄食组(SE/LAC)、耐力运动加车辆摄食组(EX/ CON)、乳酸摄食加耐力运动摄食组(EX/ LAC)。小鼠进行60-70% VO2max耐力运动,有或没有口服乳酸盐,每周5天,连续4周。在研究结束时记录VO2max测量值(VO2max、耗竭时间(TTE)、呼吸交换率、脂肪氧化和碳水化合物氧化)。测定VO2max 48 h后,处死小鼠,收集三种不同的腹部脂肪样本(附睾、肾周和肠系膜)。结果:两组间体重和腹部脂肪量无显著差异。当测量VO2max时,耐力运动提高了VO2max,耐力运动后乳酸摄入增加了TTE。测定VO2max时能量底物利用率的变化表明,虽然乳酸摄入提高了呼吸交换率和脂肪氧化,但乳酸摄入和耐力运动没有协同作用。结论:耐力运动后立即摄入乳酸可改善运动表现,说明长期摄入外源性乳酸作为运动补充的益处。
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引用次数: 0
Effect of curcumin supplementation on inflammatory status and muscle damage in competitive female soccer players: a placebo-controlled, singleblind, nonrandomized, crossover pilot study. 姜黄素补充剂对竞技女足运动员炎症状态和肌肉损伤的影响:一项安慰剂对照、单盲、非随机、交叉先导研究。
Pub Date : 2023-06-01 DOI: 10.20463/pan.2023.0016
Youngju Choi, Song-Gyu Ra, Takahiko Nishijima, Seiji Maeda

Purpose: Curcumin, a major component of turmeric, has anti-inflammatory and antioxidative properties, which are associated with protective effects against muscle damage. This study examined the effects of dietary curcumin on inflammation and muscle damage in female competitive soccer players.

Methods: A single-blinded, placebo-controlled, nonrandomized, crossover pilot study was conducted. Six competitive female soccer players (20.0 ± 2.0 yearsold) who participated in a 2-week preseason training program were assigned to two conditions: placebo and curcumin. The participants ingested a placebo or curcumin dosage (270 mg/day) during 2 weeks of preseason training, with 1 week of washout. Fasting blood samples were collected under resting conditions before (day 0) and after (day 15) the training period to examine changes in the concentration of interleukin 6 (IL-6), an inflammatory marker, and indices reflective of muscle damage.

Results: Curcumin decreased the concentration of IL-6 released (mean decrease, -30.2 ± 28.1%), whereas no decrease was observed in the placebo condition (13.4 ± 17.4%). Changes in plasma IL-6 concentrations were significantly greater in the curcumin condition than in the placebo condition (p < 0.05). However, curcumin supplementation had no significant effects on muscle damage indices.

Conclusion: The present study shows that curcumin supplementation could attenuate inflammation, as indicated by IL-6 concentrations, in competitive female soccer players during the training period.

目的:姜黄素是姜黄的主要成分,具有抗炎和抗氧化的特性,这与防止肌肉损伤的保护作用有关。本研究考察了姜黄素对女性竞技足球运动员炎症和肌肉损伤的影响。方法:采用单盲、安慰剂对照、非随机、交叉先导研究。6名女子足球运动员(20.0±2.0岁)参加了为期2周的季前训练计划,被分配到两种情况:安慰剂和姜黄素。参与者在2周的季前训练期间摄入安慰剂或姜黄素剂量(270毫克/天),并进行1周的冲洗。在训练前(第0天)和训练后(第15天)静息条件下采集空腹血样,检测炎症标志物白细胞介素6 (IL-6)浓度的变化以及反映肌肉损伤的指标。结果:姜黄素降低IL-6释放浓度(平均降低-30.2±28.1%),而安慰剂组未见降低(13.4±17.4%)。姜黄素组血浆IL-6浓度的变化明显大于安慰剂组(p <0.05)。而添加姜黄素对肌肉损伤指标无显著影响。结论:本研究表明,姜黄素的补充可以减轻女足运动员训练期间的炎症反应,正如IL-6浓度所显示的那样。
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引用次数: 0
Anti-obesity effects of Camellia (Camellia oleifera Abel) oil treatment on high-fat diet-induced obesity in C57BL/6J mice. 山茶油对C57BL/6J小鼠高脂饮食性肥胖的抗肥胖作用
Pub Date : 2023-06-01 DOI: 10.20463/pan.2023.0018
Ramakrishna Chilakala, Hyeon Jeong Moon, Kiwoong Kim, Soyoung Yang, Sun Hee Cheong

Purpose: In the current study, we investigated the effects of camellia oil and camellia oil infused with herbs (Camellia oleifera Abel) on obesity in obese mice fed a high-fat diet (HFD).

Methods: The antioxidant activity of camellia oil in scavenging free radicals was investigated. Additionally, body and organ weight changes, serum and liver marker parameters, antioxidant enzyme activities, liver and epididymal fat histology, protein and gene expression associated with lipogenesis and hyperglycemia effect on adenosine monophosphate-activated protein kinase (AMPK) phosphorylation, were examined in HFD-induced obese mice.

Results: The hepatic steatosis and epididymal fat were significantly reduced by the oral administration of camellia oil and herb-infused camellia oil. Moreover, hepatic and serum marker parameters such as total cholesterol, insulin, triglycerides, tumor necrosis factor-α, adiponectin, thiobarbituric acid reactive substances, aspartate aminotransferase, and alanine transaminase were beneficially impacted. Additionally, the activity of antioxidant enzymes also increased. Camellia oil and herb-infused camellia oil treatments reduced the expression of genes linked to hyperglycemia and lipogenesis via activation of AMPK phosphorylation.

Conclusion: For many people, exercise poses an obstacle in the daily routine due to lack of ease, difficulty in maintaining consistency, and hard work. Camellia oil combined with herbs has anti-obesity and antihyperglycemic effects. These findings indicate that treatment with herb-infused camellia oil is most beneficial for elderly individuals who do not prefer frequent exercise.

目的:在本研究中,我们研究了山茶油和山茶油浸膏(camellia oleifera Abel)对高脂饮食(HFD)肥胖小鼠肥胖的影响。方法:研究茶油对自由基的清除作用。此外,我们还检测了hfd诱导的肥胖小鼠的身体和器官重量变化、血清和肝脏标志物参数、抗氧化酶活性、肝脏和附睾脂肪组织学、与脂肪生成和高血糖相关的蛋白质和基因表达对单磷酸腺苷活化蛋白激酶(AMPK)磷酸化的影响。结果:口服山茶油和中草药茶油均能显著降低大鼠肝脂肪变性和附睾脂肪。此外,肝脏和血清标志物参数如总胆固醇、胰岛素、甘油三酯、肿瘤坏死因子-α、脂联素、硫代巴比妥酸活性物质、天冬氨酸转氨酶和丙氨酸转氨酶均受到有益影响。此外,抗氧化酶的活性也有所提高。山茶油和草药注入山茶油处理通过激活AMPK磷酸化降低了与高血糖和脂肪生成相关的基因的表达。结论:对很多人来说,锻炼在日常生活中构成了障碍,因为锻炼不容易,很难保持一致性,而且需要付出很大的努力。山茶油与草药结合具有抗肥胖、抗高血糖的作用。这些发现表明,用草药注入的茶油治疗对不喜欢经常锻炼的老年人最有益。
{"title":"Anti-obesity effects of Camellia (Camellia oleifera Abel) oil treatment on high-fat diet-induced obesity in C57BL/6J mice.","authors":"Ramakrishna Chilakala,&nbsp;Hyeon Jeong Moon,&nbsp;Kiwoong Kim,&nbsp;Soyoung Yang,&nbsp;Sun Hee Cheong","doi":"10.20463/pan.2023.0018","DOIUrl":"https://doi.org/10.20463/pan.2023.0018","url":null,"abstract":"<p><strong>Purpose: </strong>In the current study, we investigated the effects of camellia oil and camellia oil infused with herbs (Camellia oleifera Abel) on obesity in obese mice fed a high-fat diet (HFD).</p><p><strong>Methods: </strong>The antioxidant activity of camellia oil in scavenging free radicals was investigated. Additionally, body and organ weight changes, serum and liver marker parameters, antioxidant enzyme activities, liver and epididymal fat histology, protein and gene expression associated with lipogenesis and hyperglycemia effect on adenosine monophosphate-activated protein kinase (AMPK) phosphorylation, were examined in HFD-induced obese mice.</p><p><strong>Results: </strong>The hepatic steatosis and epididymal fat were significantly reduced by the oral administration of camellia oil and herb-infused camellia oil. Moreover, hepatic and serum marker parameters such as total cholesterol, insulin, triglycerides, tumor necrosis factor-α, adiponectin, thiobarbituric acid reactive substances, aspartate aminotransferase, and alanine transaminase were beneficially impacted. Additionally, the activity of antioxidant enzymes also increased. Camellia oil and herb-infused camellia oil treatments reduced the expression of genes linked to hyperglycemia and lipogenesis via activation of AMPK phosphorylation.</p><p><strong>Conclusion: </strong>For many people, exercise poses an obstacle in the daily routine due to lack of ease, difficulty in maintaining consistency, and hard work. Camellia oil combined with herbs has anti-obesity and antihyperglycemic effects. These findings indicate that treatment with herb-infused camellia oil is most beneficial for elderly individuals who do not prefer frequent exercise.</p>","PeriodicalId":74444,"journal":{"name":"Physical activity and nutrition","volume":"27 2","pages":"50-61"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/9f/30/pan-2023-0018.PMC10440180.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10048788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
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Physical activity and nutrition
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