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Factors affecting weight management in overweight or obese diabetic patients: the 2018-2021 Korea national health and nutrition examination survey. 影响超重或肥胖糖尿病患者体重管理的因素:2018-2021 年韩国国民健康与营养检查调查。
Pub Date : 2024-03-01 Epub Date: 2024-03-31 DOI: 10.20463/pan.2024.0004
Young-Ran Yeun, Yi Sub Kwak, Hye-Young Kim

Purpose: Diabetes is a chronic metabolic disease that affects approximately 422 million people worldwide and leads to the death of 1.5 million people every year. The prevalence of diabetes among the population aged 30 or older in Korea has steadily increased since 2018, reaching 16.7% in 2020, with one in six adults having diabetes. This study was conducted to identify factors affecting weight management in overweight or obese patients with diabetes (OOPD) in Korea using data from the 2018-2022 National Health and Nutrition Examination Survey. Therefore, the goal of this study is to analyze weight perception and factors related to weight perception and to identify factors that influence weight loss efforts among OOPD in Korea.

Methods: Socioeconomic characteristics, disease morbidity, weight perception, and weight loss efforts were investigated in 950 participants. Data were analyzed using descriptive statistics, cross-tabulation, and logistic regression.

Results: Among the overweight or obese patients with diabetes, 24.4% perceived their weight to be normal, with a higher proportion among men (29.6%) than among women (14.6%). Weight loss efforts were 5.11 times (95% CI: 3.02-8.66) higher in people with overweight perceptions than in those with normal weight perceptions. Additionally, the rate was 1.54 times (95% CI: 1.06 2.25) higher in people with dyslipidemia than in those without dyslipidemia.

Conclusion: These results suggest that weight management approaches for overweight or obese patients with diabetes should be designed individually based on weight perception and disease morbidity.

目的:糖尿病是一种慢性代谢性疾病,全球约有 4.22 亿人患糖尿病,每年导致 150 万人死亡。自 2018 年以来,韩国 30 岁及以上人口的糖尿病患病率稳步上升,2020 年将达到 16.7%,每六个成年人中就有一人患有糖尿病。本研究利用 2018-2022 年全国健康与营养调查的数据,旨在确定影响韩国超重或肥胖糖尿病患者(OOPD)体重管理的因素。因此,本研究的目标是分析体重感知及与体重感知相关的因素,并确定影响韩国 OOPD 减肥努力的因素:方法:调查了 950 名参与者的社会经济特征、疾病发病率、体重感知和减肥努力。采用描述性统计、交叉表法和逻辑回归法对数据进行分析:结果:在超重或肥胖的糖尿病患者中,24.4%的人认为自己体重正常,其中男性(29.6%)的比例高于女性(14.6%)。认为自己体重超标的患者的减肥努力是认为自己体重正常的患者的 5.11 倍(95% CI:3.02-8.66)。此外,血脂异常者的减肥率是无血脂异常者的 1.54 倍(95% CI:1.06-2.25):这些结果表明,针对超重或肥胖糖尿病患者的体重管理方法应根据体重感知和疾病发病率进行个性化设计。
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引用次数: 0
Effects of public transportation use on non-exercise activity thermogenesis and health promotion: a mini-review. 使用公共交通对非运动活动产热和健康促进的影响:微型综述。
Pub Date : 2024-03-01 Epub Date: 2024-03-31 DOI: 10.20463/pan.2024.0005
Sung-Woo Kim, Deunsol Hwang, Sunghwan Kyun, Inkwon Jang, Taeho Kim, Jongwon Kim, Inseop Shin, Kiwon Lim

Purpose: Public transportation (PT) systems significantly shape urban mobility and have garnered attention owing to their potential impact on public health, particularly the promotion of physical activity. Beyond their transportation functions, PT systems also affect daily energy expenditure through non-exercise activity thermogenesis (NEAT). This mini-review surveys the existing literature to explore the effects of PT use on NEAT levels and subsequent health outcomes.

Methods: A comprehensive literature search was conducted using the electronic databases PubMed, Google Scholar, and Web of Science. Keywords including "public transportation," "non-exercise activity thermogenesis," "physical activity," "health promotion," and related terms were used to identify relevant studies.

Results: This review highlights the multifaceted relationship between PT use and health promotion, emphasizing the potential benefits and challenges of increasing NEAT through public transit utilization. Overall, the findings suggest that PT use contributes positively to NEAT levels, and thus improves health outcomes. However, the extent of this impact may vary depending on individual and contextual factors.

Conclusion: Interventions promoting active transportation modes, including public transit, hold promise for addressing sedentary behavior and fostering healthier lifestyles at the population level.

目的:公共交通(PT)系统在很大程度上影响着城市的流动性,由于其对公众健康的潜在影响,尤其是对促进体育锻炼的潜在影响,因而备受关注。除交通功能外,公共交通系统还通过非运动活动产热(NEAT)影响日常能量消耗。本微型综述对现有文献进行了调查,以探讨公共交通的使用对非运动产热水平及随后的健康结果的影响:方法:使用电子数据库 PubMed、Google Scholar 和 Web of Science 进行了全面的文献检索。关键词包括 "公共交通"、"非运动活动产热"、"体育活动"、"健康促进 "及相关术语,以确定相关研究:结果:本综述强调了使用公共交通与促进健康之间的多方面关系,强调了通过使用公共交通增加非运动热量的潜在益处和挑战。总体而言,研究结果表明,使用公共交通有助于提高近地活动能力水平,从而改善健康状况。然而,这种影响的程度可能因个人和环境因素而异:结论:推广包括公共交通在内的积极交通模式的干预措施有望解决久坐问题,并在人口层面培养更健康的生活方式。
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引用次数: 0
Effect of blood flow restriction with low-intensity resistance training in patients with osteoarthritis and rheumatoid arthritis: a systematic review and meta-analysis based on randomized controlled trials. 低强度阻力训练对骨关节炎和类风湿性关节炎患者的血流限制效果:基于随机对照试验的系统回顾和荟萃分析。
Pub Date : 2024-03-01 Epub Date: 2024-03-31 DOI: 10.20463/pan.2024.0002
Junzhen Huang, Hun-Young Park

Purpose: This study evaluated the effects of blood flow restriction with low-intensity resistance training (BFR + LIRT) on pain, adverse events, muscle strength, and function in patients with osteoarthritis (OA) and rheumatoid arthritis (RA) through a systematic review and meta-analysis.

Methods: This study adhered to the guidelines of the Preferred Reporting Items for Systematic Review and Meta-Analyses 2020 (PRISMA 2020) and applied the A Measurement Tool to Assess Systematic Reviews 2 (AMSTAR2) standards to ensure the high quality of the systematic review. A comprehensive literature search was conducted until August 2023 using four selected keywords (osteoarthritis, rheumatoid arthritis, blood flow restriction training, and resistance training) across five search engines (PubMed, Embase, Web of Science, CENTRAL, and PEDro).

Results: Ten studies were analyzed. The results showed that BFR + LIRT had similar effects on pain, risk of adverse events, muscle strength, self-reported function, and physical function compared with resistance training (RT).

Conclusion: This systematic review and meta-analysis further support the potential of BFR + LIRT in the disease management of patients with OA or RA. According to this analysis, BFR + LIRT had a lower risk of adverse events than high-intensity resistance training (HIRT) and may be a safer training modality. BFR + LIRT offers greater advantages in improving physical function than LIRT and was able to provide similar benefits to HIRT without increasing the training load. These findings suggest that BFR + LIRT is a safe and effective strategy for treating patients with OA or RA. However, owing to the limited number of studies covered in this analysis, additional higher-quality studies are needed to strengthen this conclusion.

目的:本研究通过系统综述和荟萃分析评估了血流限制与低强度阻力训练(BFR + LIRT)对骨关节炎(OA)和类风湿性关节炎(RA)患者的疼痛、不良事件、肌肉力量和功能的影响:本研究遵循《2020 年系统综述和荟萃分析首选报告项目》(PRISMA 2020)指南,并采用《评估系统综述的测量工具 2》(AMSTAR2)标准,以确保系统综述的高质量。截至 2023 年 8 月,在五个搜索引擎(PubMed、Embase、Web of Science、CENTRAL 和 PEDro)上使用四个选定关键词(骨关节炎、类风湿性关节炎、血流限制训练和阻力训练)进行了全面的文献检索:结果:分析了 10 项研究。结果显示,与阻力训练(RT)相比,BFR + LIRT 对疼痛、不良事件风险、肌肉力量、自我报告功能和身体功能的影响相似:本系统综述和荟萃分析进一步证实了阻力训练+LIRT 在治疗 OA 或 RA 患者疾病方面的潜力。根据这项分析,BFR + LIRT 比高强度阻力训练(HIRT)发生不良事件的风险更低,可能是一种更安全的训练方式。与 LIRT 相比,BFR + LIRT 在改善身体功能方面具有更大的优势,而且在不增加训练负荷的情况下也能提供与 HIRT 类似的益处。这些研究结果表明,BFR + LIRT 是治疗 OA 或 RA 患者的一种安全有效的策略。然而,由于本分析所涉及的研究数量有限,因此需要更多更高质量的研究来加强这一结论。
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引用次数: 0
Influence of sitting time on pulmonary function in computerusing office workers. 久坐对电脑办公人员肺功能的影响
Pub Date : 2024-03-01 Epub Date: 2024-03-31 DOI: 10.20463/pan.2024.0003
Aditi Upmanyu, Amit Kumar, Varun Kalia

Purpose: We aimed to identify the changes in pulmonary function after prolonged sitting. Pulmonary function tests (PFTs) allow physicians to assess the respiratory capability of patients under numerous clinical circumstances and when there are risk factors for lung sickness, occupational exposure, and pulmonary toxicity. PFTs are routinely performed in the standing or high sitting position because of the devices and patient comfort.

Methods: A total of 180 asymptomatic office workers were recruited as eligibility criteria and divided into three groups according to their daily sitting duration (group 1:2-4 h, group 2:4-6 h, and group 3: > 6 h). PFTs were performed twice consecutively to determine the mean of the readings. A Helios 401 spirometer was used to quantify lung function. The parameters were "forced expiratory volume in 1 s (FEV1)", "forced vital capacity (FVC)", "peak expiratory flow rate (PEFR)", and the "ratio of FEV1 to FVC (FEV1/FVC)".

Results: Our results suggest that noteworthy changes were present in the lung function of all the participants. For individuals with > 6 h of sitting; FVC, FEV1, and PEFR were higher compared to those of the participants with 2-4 h and 4-6 h of sitting. The FEV1/FVC ratio was also reduced in individuals with prolonged hours of sitting.

Conclusion: Body position impacts the result of PFTs; however, that as it may, the ideal position and extent of advantage changed between the review populaces. These results suggested that noteworthy changes occur in the lung function of healthy individuals exposed to sitting time.

目的:我们旨在确定久坐后肺功能的变化。肺功能检查(PFTs)使医生能够在多种临床情况下以及存在肺部疾病、职业暴露和肺毒性等危险因素时评估患者的呼吸能力。由于设备和患者舒适度的原因,PFT 通常在站立或高坐位进行:方法:以 180 名无症状的办公室工作人员为合格标准,根据他们每天的坐姿时间分为三组(第一组:2-4 小时;第二组:4-6 小时;第三组:> 6 小时)。连续进行两次肺活量检查,以确定读数的平均值。使用 Helios 401 肺活量计对肺功能进行量化。参数包括 "1 秒用力呼气容积(FEV1)"、"用力肺活量(FVC)"、"呼气峰流速(PEFR)"和 "FEV1 与 FVC 之比(FEV1/FVC)":结果表明,所有参与者的肺功能都发生了显著变化。与久坐 2-4 小时和 4-6 小时的参与者相比,久坐时间超过 6 小时的参与者的肺活量、肺活量1 和肺活量增加。久坐者的 FEV1/FVC 比值也有所下降:结论:体位对肺活量测量结果有影响;然而,尽管如此,不同人群的理想体位和优势程度却有所不同。这些结果表明,久坐的健康人肺功能会发生显著变化。
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引用次数: 0
Effects of post-exercise intake of exogenous lactate on energy substrate utilization at rest. 运动后摄入外源性乳酸盐对静息时能量底物利用的影响。
Pub Date : 2024-03-01 Epub Date: 2024-03-31 DOI: 10.20463/pan.2024.0001
Taeho Kim, Deunsol Hwang, Sunghwan Kyun, Inkwon Jang, Sung-Woo Kim, Hun-Young Park, Kiwon Lim, Charyong Kim, Jisu Kim

Purpose: This study investigated the effects of exogenous lactate intake on energy metabolism during 1 h of rest after acute exercise.

Methods: Eight-week-old ICR mice were randomly divided into four groups: SED (no treatment), EXE (exercise only), LAC (post-exercise oral lactate administration), and SAL (post-exercise saline administration) (n=8 per group). The exercise intensity was at VO2max 80% at 25 m/min and 15° slope for 50 min. After acute exercise, the LAC and SAL groups ingested lactate and saline orally, respectively, and were allowed to rest in a chamber. Energy metabolism was measured for 1 h during the resting period.

Results: LAC and SAL group mice ingested lactate and saline, respectively, after exercise and the blood lactate concentration was measured 1 h later through tail blood sampling. Blood lactate concentration was not significantly different between the two groups. Energy metabolism measurements under stable conditions revealed that the respiratory exchange ratio in the LAC group was significantly lower than that in the SAL group. Additionally, carbohydrate oxidation in the LAC group was significantly lower than that in the SAL group at 10-25 min. No significant difference was observed in the fat oxidation level between the two groups.

Conclusion: We found that post-exercise lactate intake modified the respiratory exchange ratio after 1 h of rest. In addition, acute lactate ingestion inhibits carbohydrate oxidation during the post-exercise recovery period.

目的:本研究探讨了摄入外源性乳酸盐对急性运动后休息 1 小时内能量代谢的影响:将 8 周大的 ICR 小鼠随机分为 4 组:方法:将八周龄的ICR小鼠随机分为四组:SED组(无处理)、EXE组(仅运动)、LAC组(运动后口服乳酸盐)和SAL组(运动后口服生理盐水)(每组n=8)。运动强度为 VO2max 80%,速度为 25 米/分钟,坡度为 15°,持续 50 分钟。急性运动后,LAC 组和 SAL 组分别口服乳酸盐和生理盐水,并在室内休息。在休息期间测量了1小时的能量代谢:结果:LAC组和SAL组小鼠在运动后分别摄入乳酸盐和生理盐水,1小时后通过尾部采血测量血液乳酸盐浓度。两组小鼠的血液乳酸浓度无明显差异。稳定条件下的能量代谢测量显示,LAC 组的呼吸交换比明显低于 SAL 组。此外,在 10-25 分钟内,LAC 组的碳水化合物氧化率明显低于 SAL 组。结论:我们发现,运动后摄入乳酸盐会改变休息 1 小时后的呼吸交换比。此外,急性乳酸盐摄入会抑制运动后恢复期的碳水化合物氧化。
{"title":"Effects of post-exercise intake of exogenous lactate on energy substrate utilization at rest.","authors":"Taeho Kim, Deunsol Hwang, Sunghwan Kyun, Inkwon Jang, Sung-Woo Kim, Hun-Young Park, Kiwon Lim, Charyong Kim, Jisu Kim","doi":"10.20463/pan.2024.0001","DOIUrl":"10.20463/pan.2024.0001","url":null,"abstract":"<p><strong>Purpose: </strong>This study investigated the effects of exogenous lactate intake on energy metabolism during 1 h of rest after acute exercise.</p><p><strong>Methods: </strong>Eight-week-old ICR mice were randomly divided into four groups: SED (no treatment), EXE (exercise only), LAC (post-exercise oral lactate administration), and SAL (post-exercise saline administration) (n=8 per group). The exercise intensity was at VO2max 80% at 25 m/min and 15° slope for 50 min. After acute exercise, the LAC and SAL groups ingested lactate and saline orally, respectively, and were allowed to rest in a chamber. Energy metabolism was measured for 1 h during the resting period.</p><p><strong>Results: </strong>LAC and SAL group mice ingested lactate and saline, respectively, after exercise and the blood lactate concentration was measured 1 h later through tail blood sampling. Blood lactate concentration was not significantly different between the two groups. Energy metabolism measurements under stable conditions revealed that the respiratory exchange ratio in the LAC group was significantly lower than that in the SAL group. Additionally, carbohydrate oxidation in the LAC group was significantly lower than that in the SAL group at 10-25 min. No significant difference was observed in the fat oxidation level between the two groups.</p><p><strong>Conclusion: </strong>We found that post-exercise lactate intake modified the respiratory exchange ratio after 1 h of rest. In addition, acute lactate ingestion inhibits carbohydrate oxidation during the post-exercise recovery period.</p>","PeriodicalId":74444,"journal":{"name":"Physical activity and nutrition","volume":"28 1","pages":"1-6"},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11079383/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140893084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nutritional knowledge, eating habits, factors affecting muscle damage, and antioxidant enzyme levels of Korean wrestlers. 韩国摔跤运动员的营养知识、饮食习惯、影响肌肉损伤的因素以及抗氧化酶水平。
Pub Date : 2024-03-01 Epub Date: 2024-03-31 DOI: 10.20463/pan.2024.0008
Yun-Seok Lee, Dong-Ryul Lee, Hyoung-Rok Lee, Jun-Young Sung

Purpose: The aim in this study was to investigate the diet and nutritional knowledge of elite Korean wrestlers and verify the differences in their exercise performance , muscle damage indicators, and antioxidant enzyme levels according to wrestler level.

Methods: A 7-day dietary and nutrition knowledge survey was administered to 30 adult male elite wrestlers (national team: n=11; professional team: n=19). The Wingate test was conducted for 60 seconds to analyze muscle damage indicators and antioxidant levels. Blood and blood lactate concentration analyses were performed four times; the statistical significance level of all data was p<0.05.

Results: Significant differences were found in general nutrition knowledge questionnaire (GNKQ) scores (p=0.043), diet (p=0.001), anaerobic performance (p=0.001), muscle damage indicators (p=0.026), antioxidant levels, and blood lactic acid concentrations (30 min after exercise, p=0.007; 90 min after exercise, p=0.038) between the national and the professional groups.

Conclusion: To the findings confirm the relationship between the differences in diet, nutrition, and motor function for wrestlers of different expertise levels. In a follow-up, a comprehensive study on nutrition knowledge, athlete training , and weight loss is needed that considers a wider scope of subjects and analyzes additional variables.

目的:本研究旨在调查韩国精英摔跤运动员的饮食和营养知识,并验证不同级别摔跤运动员在运动表现、肌肉损伤指标和抗氧化酶水平方面的差异:对 30 名成年男性精英摔跤运动员(国家队:11 人;专业队:19 人)进行了为期 7 天的饮食和营养知识调查。进行 60 秒钟的 Wingate 测试,以分析肌肉损伤指标和抗氧化剂水平。血液和血乳酸浓度分析共进行了四次;所有数据的统计学显著性水平均为 pResults:在营养常识问卷(GNKQ)得分(p=0.043)、饮食(p=0.001)、无氧运动表现(p=0.001)、肌肉损伤指标(p=0.026)、抗氧化剂水平和血液乳酸浓度(运动后 30 分钟,p=0.007;运动后 90 分钟,p=0.038)方面,国家组和专业组之间存在显著差异:研究结果证实了不同专业水平的摔跤运动员在饮食、营养和运动功能方面的差异之间的关系。在后续研究中,需要对营养知识、运动员训练和减肥进行全面研究,研究对象范围要更广,并分析更多变量。
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引用次数: 0
Cranberry supplementation improves physiological markers of performance in trained runners. 补充蔓越莓可改善训练有素的跑步者的生理指标。
Pub Date : 2023-12-01 Epub Date: 2023-12-31 DOI: 10.20463/pan.2023.0032
Francis Parenteau, Veronica Furno Puglia, Mary Roberts, Alain Steve Comtois, Andreas Bergdahl

Purpose: Cranberries have the highest polyphenol and antioxidant capacity among fruits and vegetables and may protect against exercise-induced free radical production, consequently improving performance. This study aimed to investigate the effect of polyphenol-rich cranberry extract (CE) on time-trial performance and lactate response following exercise.

Methods: A total of 14 trained runners were tested at i) baseline, ii) 2 h following an acute CE dose (0.7 g/kg of body mass), and iii) 4 weeks after daily supplement consumption (0.3 g/kg of body mass). At each time point, runners performed a 1500-m race followed by a 400-m race where the live vastus lateralis oxygenation changes were determined by near-infrared spectroscopy and blood lactate was measured at rest and 1 and 3 min after each trial. The Shapiro-Wilk test and repeated-measures analysis of variance were used to establish significance (P <0.05).

Results: Cranberry supplementation over 28 d improved aerobic performance during the 1500-m time trial, whereas the acute dose had no effect. More specifically, muscle reoxygenation rates were significantly faster after 28 d compared to baseline (P = 0.04; η² = 0.29), and a trend towards slower deoxygenation rate was observed (P = 0.13; η² = 0.20). Chronic CE consumption also buffered the post-exercise lactate response for the 400-m race (P = 0.01; η² = 0.27), while no effects were seen for the longer race.

Conclusion: Our results suggest that cranberry supplementation may have ergogenic effects, as it improves physiological markers of performance during short- and long-distance running.

目的:蔓越莓在水果和蔬菜中具有最高的多酚和抗氧化能力,可防止运动引起的自由基生成,从而提高运动成绩。本研究旨在探讨富含多酚的蔓越莓提取物(CE)对运动后计时成绩和乳酸反应的影响:方法:共对 14 名训练有素的跑步者进行了以下测试:i)基线;ii)服用急性 CE 剂量(0.7 克/千克体重)后 2 小时;iii)每天服用补充剂(0.3 克/千克体重)4 周后。在每个时间点,跑步者先进行 1500 米赛跑,然后进行 400 米赛跑,通过近红外光谱测定活体阔筋膜氧饱和度的变化,并测量休息时和每次赛跑后 1 分钟和 3 分钟的血乳酸。采用 Shapiro-Wilk 检验和重复测量方差分析来确定显著性(P <0.05):结果:在1500米计时赛中,连续28天补充蔓越莓可提高有氧运动成绩,而急性剂量则没有影响。更具体地说,与基线相比,28 天后肌肉再氧合速率明显加快(P = 0.04;η² = 0.29),并且观察到脱氧速率有减慢的趋势(P = 0.13;η² = 0.20)。长期食用蔓越莓还能缓冲 400 米赛跑的运动后乳酸反应(P = 0.01;η² = 0.27),而对长距离赛跑则没有影响:我们的研究结果表明,补充蔓越莓可能具有增强体质的作用,因为它能改善短距离和长距离跑步时的生理指标。
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引用次数: 0
Potential involvement of neutrophils on exercise effects in breast cancer malignancy. 中性粒细胞对乳腺癌恶性肿瘤运动效应的潜在影响
Pub Date : 2023-12-01 Epub Date: 2023-12-31 DOI: 10.20463/pan.2023.0036
Kangeun Ko, Song Won Woo, Young Chan Chae, Minchul Lee, Hyo Youl Moon

Purpose: This review aimed to comprehensively explore and elucidate multifaceted neutrophils in breast cancer, particularly in the context of physical activity. Neutrophils play a critical role in the tumor microenvironment and systemic immune response, despite their short half-life and terminal differentiation. Through a thorough review of research related to changes in immunity in breast cancer during exercise, this review aims to provide comprehensive insights into immunological changes, especially focusing on neutrophils. Recognizing that much of the existing research has predominantly focused on T cells and nature killer (NK) cells, our review seeks to shift the spotlight toward understanding how exercise affects neutrophils, a less-explored but critical immune response component in breast cancer.

Methods: This study involved an extensive review of the literature (from 2000 to 2023) using the PubMed, Science Direct, and Google Scholar databases. The keywords chosen for the searches were "immune cells and exercise," "exercise and breast cancer," "tumor microenvironment and neutrophils," and "neutrophils and exercise and breast cancers."

Results: Neutrophils in the tumor microenvironment can exhibit distinct phenotypes and functions. These differences have yielded conflicting results regarding tumor progression. Exercise plays a positive role in breast cancer and alters the immune system. Physical activity can quantitatively and functionally regulate neutrophils under various conditions such as metabolic disruption or senescence.

Conclusion: This short communication outlines exercise-induced neutrophil diversification and its role in breast cancer progression, both within and systemically within the tumor microenvironment. Exercise may provide benefits through the potential neutrophil involvement in breast cancer.

目的:这篇综述旨在全面探讨和阐明中性粒细胞在乳腺癌中的多方面作用,尤其是在体育锻炼的背景下。尽管中性粒细胞的半衰期短、分化终末,但它们在肿瘤微环境和全身免疫反应中发挥着至关重要的作用。本综述通过对运动期间乳腺癌免疫变化相关研究的全面回顾,旨在提供有关免疫变化的全面见解,尤其侧重于中性粒细胞。我们认识到现有的大部分研究主要集中在 T 细胞和自然杀伤(NK)细胞上,因此我们的综述试图将焦点转向了解运动如何影响中性粒细胞,这是乳腺癌中一种较少被研究但却至关重要的免疫反应成分:本研究使用 PubMed、Science Direct 和 Google Scholar 数据库对文献(2000 年至 2023 年)进行了广泛综述。搜索关键词为 "免疫细胞与运动"、"运动与乳腺癌"、"肿瘤微环境与中性粒细胞 "以及 "中性粒细胞与运动和乳腺癌":肿瘤微环境中的中性粒细胞可表现出不同的表型和功能。这些差异在肿瘤进展方面产生了相互矛盾的结果。运动对乳腺癌有积极作用,并能改变免疫系统。在新陈代谢紊乱或衰老等各种条件下,体育锻炼可从数量和功能上调节中性粒细胞:这篇短文概述了运动诱导的中性粒细胞多样化及其在乳腺癌进展过程中的作用,包括在肿瘤微环境内部和系统中的作用。运动可通过中性粒细胞对乳腺癌的潜在参与而带来益处。
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引用次数: 0
Effects of resistance training and protein supplementation interventions on muscle volume and muscle function: sex differences in humans. 阻力训练和蛋白质补充干预对肌肉体积和肌肉功能的影响:人类的性别差异。
Pub Date : 2023-12-01 Epub Date: 2023-12-31 DOI: 10.20463/pan.2023.0033
Ki-Woong Noh, Sok Park

Purpose: This review aimed to identify differences in the effects of co-intervention with resistance training (RT) and protein supplementation according to sex and provide meaningful information for future research on the development of exercise programs to improve muscle volume and muscle function.

Methods: PubMed, Science Direct, and Google Scholar were searched to identify clinical and nonclinical studies that assessed the effects of RT in older adults with sarcopenia; these studies were published between 1990 and 2023. Cross-sectional and double-blind studies (randomized controlled trials, RCTs) were examined in this review.

Results: The effects of parallel intervention with RT and protein supplementation on muscle volume and physical function were found to differ according to sex. Both males and females had improvements in muscle strength, muscle mass, and physical function after RT and protein supplementation; however, many studies found a greater increase in muscle volume and function in males than in females. Such difference may be due to differences in physiological characteristics between males and females.

Conclusion: Based on the findings of this review, the effects of combined intervention with RT and protein supplementation on muscle strength, muscle mass, and physical function to differ according to sex. Owing to these sex differences in the response and physiological characteristics caused by the parallel intervention of RT and protein supplementation, such differences must be considered to maximize the effects of RT and protein supplementation.

目的:本综述旨在根据性别确定阻力训练(RT)和蛋白质补充联合干预效果的差异,并为未来开发运动项目以改善肌肉体积和肌肉功能的研究提供有意义的信息:对 PubMed、Science Direct 和 Google Scholar 进行了检索,以确定评估 RT 对患有肌肉疏松症的老年人的影响的临床和非临床研究;这些研究发表于 1990 年至 2023 年之间。本综述研究了横断面研究和双盲研究(随机对照试验,RCT):结果发现,RT 和蛋白质补充并行干预对肌肉体积和身体功能的影响因性别而异。男性和女性在补充 RT 和蛋白质后,肌肉力量、肌肉质量和身体功能都有所改善;但许多研究发现,男性肌肉体积和功能的增加幅度大于女性。这种差异可能是由于男性和女性的生理特点不同造成的:根据本综述的研究结果,RT 和蛋白质补充联合干预对肌肉力量、肌肉质量和身体功能的影响因性别而异。由于RT和蛋白质补充并行干预在反应和生理特点上存在性别差异,因此必须考虑这种差异,以最大限度地发挥RT和蛋白质补充的效果。
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引用次数: 0
Rosae multiflorae fructus regulates the lipogenesis in high-fat diet-induced NAFLD mice model. 多花蔷薇果能调节高脂饮食诱导的非酒精性脂肪肝小鼠模型的脂肪生成。
Pub Date : 2023-12-01 Epub Date: 2023-12-31 DOI: 10.20463/pan.2023.0038
Kibong Kim, Hyun Joo Jang, Suji Baek, Sang-Hyun Ahn

Purpose: Exercise helps modify the lipid profile in the body, partly through its impact on sterol regulatory element binding protein-1 (SREBP-1) and peroxisome proliferator-activated receptor-γ (PPAR-γ). Individual differences in response to exercise and genetic variations may influence the response to PA. Therefore, this study explored Rosae multiflorae fructus (RMF) as a supplement candidate that improves exercise capacity and controls non-alcoholic fatty liver disease (NAFLD) by suppressing lipogenesis and controlling lipid peroxidation.

Methods: RMF is a natural herbal medicine used in Dongui Bogam. RMF has antioxidant, anti-inflammatory, and anti-allergic effects. However, the effects of RMF on NAFLD have not yet been investigated. In this study, we examined the effects of RMF in a mouse model of high-fat diet-induced NAFLD. Mouse livers were isolated and analyzed using H&E staining and immunohistochemistry.

Results: RMF downregulated lipid peroxidation markers, such as CYP2E1, in the livers of mice with high-fat diet-induced NAFLD. Additionally, the RMF significantly reduced the lipid accumulation-related protein expression of CD36, SREBP-1, and PPAR-γ.

Conclusion: RMF exerts anti-lipid peroxidation and anti-lipogenic effects in a high-fat diet-induced NAFLD mouse model.

目的:运动有助于改变体内的血脂状况,部分原因是运动会影响固醇调节元件结合蛋白-1(SREBP-1)和过氧化物酶体增殖激活受体-γ(PPAR-γ)。运动反应的个体差异和遗传变异可能会影响对 PA 的反应。因此,本研究将多花蔷薇果(RMF)作为一种候选补充剂,通过抑制脂肪生成和控制脂质过氧化来提高运动能力和控制非酒精性脂肪肝(NAFLD):RMF是Dongui Bogam使用的一种天然草药。RMF具有抗氧化、抗炎和抗过敏作用。然而,尚未研究 RMF 对非酒精性脂肪肝的影响。在本研究中,我们研究了 RMF 对高脂饮食诱发的非酒精性脂肪肝小鼠模型的影响。小鼠肝脏被分离出来,并使用 H&E 染色法和免疫组织化学法进行分析:结果:RMF 下调了高脂饮食诱导的非酒精性脂肪肝小鼠肝脏中的脂质过氧化标记物,如 CYP2E1。此外,RMF 还能显著降低 CD36、SREBP-1 和 PPAR-γ 等脂质蓄积相关蛋白的表达:结论:在高脂饮食诱导的非酒精性脂肪肝小鼠模型中,RMF具有抗脂质过氧化和抗脂质生成的作用。
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Physical activity and nutrition
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