Pub Date : 2022-12-01DOI: 10.21608/asmj.2022.285476
M. Kassab
{"title":"DEVELOPMENT OF NOVEL ANTIMICROBIAL TETRACYCLINE ANALOG B (IODOCYCLINE) BY CHEMO-INFORMATICS.","authors":"M. Kassab","doi":"10.21608/asmj.2022.285476","DOIUrl":"https://doi.org/10.21608/asmj.2022.285476","url":null,"abstract":"","PeriodicalId":7450,"journal":{"name":"Ain Shams Medical Journal","volume":"10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90089738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-01DOI: 10.21608/asmj.2022.285470
Ebtehal Mabrouk, Galal Elhawary, Sheeren Mousa, M. Alsadany
{"title":"PREVALENCE OF OSTEOPOROTIC VERTEBRAL FRACTURES IN OLDER ADULTS FEMALES WITH TYPE 2 DIABETES MELLITUS","authors":"Ebtehal Mabrouk, Galal Elhawary, Sheeren Mousa, M. Alsadany","doi":"10.21608/asmj.2022.285470","DOIUrl":"https://doi.org/10.21608/asmj.2022.285470","url":null,"abstract":"","PeriodicalId":7450,"journal":{"name":"Ain Shams Medical Journal","volume":"110 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87713082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-01DOI: 10.21608/asmj.2022.285459
M. Abdelfatah, Michael Mamdouh, H. Ibrahim, Ahmed S. Abdelbar, M. Nosseir
{"title":"RATE OF SHUNT INFECTION AFTER MYELOMENINGOCELE REPAIR","authors":"M. Abdelfatah, Michael Mamdouh, H. Ibrahim, Ahmed S. Abdelbar, M. Nosseir","doi":"10.21608/asmj.2022.285459","DOIUrl":"https://doi.org/10.21608/asmj.2022.285459","url":null,"abstract":"","PeriodicalId":7450,"journal":{"name":"Ain Shams Medical Journal","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89348446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-01DOI: 10.21608/asmj.2022.285439
S. Gadallah, H. Badawy, Eslam Mohammed, H. Hassan, Shady Ghait, R. Ghait
{"title":"STUDY OF PLASMA PENTRAXIN 3 LEVELS AS A NOVEL MARKER VERSUS LIVER STIFFNESS FOR NONALCOHOLIC STEATOHEPATITIS IN EGYPTIAN PATIENTS","authors":"S. Gadallah, H. Badawy, Eslam Mohammed, H. Hassan, Shady Ghait, R. Ghait","doi":"10.21608/asmj.2022.285439","DOIUrl":"https://doi.org/10.21608/asmj.2022.285439","url":null,"abstract":"","PeriodicalId":7450,"journal":{"name":"Ain Shams Medical Journal","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89599817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-01DOI: 10.21608/asmj.2022.285472
M. Kassab
{"title":"NEW PRODUCTION METHOD OF BACTERIAL L-ASPRAGINASE ENZYME FROM DIFFERENT SOIL ENVIRONMENTS IN EGYPT AS ANTICANCER AGENT","authors":"M. Kassab","doi":"10.21608/asmj.2022.285472","DOIUrl":"https://doi.org/10.21608/asmj.2022.285472","url":null,"abstract":"","PeriodicalId":7450,"journal":{"name":"Ain Shams Medical Journal","volume":"26 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84675480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-09-01DOI: 10.21608/asmj.2022.270236
Hasnaa Zakaria Abdelfattah, N. Kamal, Tayseer Taha Abdel, Rahman, Ghada Khalil
Background: Cochlear implantation is a common surgical procedure for children with profound hearing loss who receive minimal or no benefit from traditional hearing aids. Auditory categorization is an important process in the perception and understanding of everyday sounds. This process involves both high level cognitive processes and low-level perceptual encoding of the acoustic signal. Aim of the work : To understand the ability of a cohort of Egyptian children with Cochlear Implant to perceive everyday sounds compared to normal hearing children. Patient and Methods: Ninety subjects divided into 2 groups were included in the present study. Group I: Fifty normal hearing children (NH). Group II: Forty CI users. A set of 18 natural stimuli were studied. They were chosen to cover a broad range of everyday sounds that corresponded to four mains a priori categories: nonlinguistic human vocalizations, animal vocalizations, environmental sounds& musical instruments. Children were asked to name/identify the sounds in an open-set identification task. Results: Results showed that cochlear implant users were different from normal hearing listeners regarding the perception of individual sounds. Normal hearing children could identify sounds better than the CI children. In normal hearing children, the best identification was for human vocalizations, while in cochlear implant children the best identification was for animal vocalizations. Both groups had lower identification scores for both environmental and musical sounds. Sound identification scores increased with increasing chronological age of both groups. Conclusion: Cochlear implant children have reduced relative ability toward identification of superordinate category of nonlinguistic human vocalizations compared to age and gender matched normal hearing children.
{"title":"CATEGORIZATION OF EVERYDAY SOUNDS BY EGYPTIAN COCHLEAR IMPLANT CHILDREN","authors":"Hasnaa Zakaria Abdelfattah, N. Kamal, Tayseer Taha Abdel, Rahman, Ghada Khalil","doi":"10.21608/asmj.2022.270236","DOIUrl":"https://doi.org/10.21608/asmj.2022.270236","url":null,"abstract":"Background: Cochlear implantation is a common surgical procedure for children with profound hearing loss who receive minimal or no benefit from traditional hearing aids. Auditory categorization is an important process in the perception and understanding of everyday sounds. This process involves both high level cognitive processes and low-level perceptual encoding of the acoustic signal. Aim of the work : To understand the ability of a cohort of Egyptian children with Cochlear Implant to perceive everyday sounds compared to normal hearing children. Patient and Methods: Ninety subjects divided into 2 groups were included in the present study. Group I: Fifty normal hearing children (NH). Group II: Forty CI users. A set of 18 natural stimuli were studied. They were chosen to cover a broad range of everyday sounds that corresponded to four mains a priori categories: nonlinguistic human vocalizations, animal vocalizations, environmental sounds& musical instruments. Children were asked to name/identify the sounds in an open-set identification task. Results: Results showed that cochlear implant users were different from normal hearing listeners regarding the perception of individual sounds. Normal hearing children could identify sounds better than the CI children. In normal hearing children, the best identification was for human vocalizations, while in cochlear implant children the best identification was for animal vocalizations. Both groups had lower identification scores for both environmental and musical sounds. Sound identification scores increased with increasing chronological age of both groups. Conclusion: Cochlear implant children have reduced relative ability toward identification of superordinate category of nonlinguistic human vocalizations compared to age and gender matched normal hearing children.","PeriodicalId":7450,"journal":{"name":"Ain Shams Medical Journal","volume":"46 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85356995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-09-01DOI: 10.21608/asmj.2022.270222
Alaa-El-Dine H. Mahmoud, K. Abdelkarim, Khaled N. Abdelhakim, W. R. E. Ghamry, M. Hussein, D. E. D. Sherif
: Background: Lymphoma is the fourth most prevalent cancer among Egyptian adults, accounting for 76.6 percent non-Hodgkin lymphoma (NHL) and 23.4 percent Hodgkin lymphoma (HL). Most patients with classic Hodgkin lymphoma (cHL) achieve long-term survival free of HL, but late complications of treatment, such as second malignancies, cardiovascular disease, pulmonary disease, and other complications, have emerged as a competing cause of death and morbidity. Aim of the Work: The aim of this work is to analyse retrospectively epidemiological and clinical outcomes of Hodgkin lymphoma patients treated in Ain Shams University hospitals (clinical oncology department) in Egypt in the period from January 2017 till December 2020. Patients and Methods: This is a retrospective study that included 70 Hodgkin lymphoma patients who attended the lymphoma clinic at the Clinical Oncology Department, Ain Shams University. In the period between From January 2017 till December 2020. They either treated by chemotherapy only or chemotherapy and radiotherapy. Result: Overall, of the 70 patients in the present study, 7 patients (10 %) died, and sixty-three patients (90 %) are alive till the end of our follow-up. The median
{"title":"A RETROSPECTIVE ANALYSIS OF EPIDEMIOLOGY AND CLINICAL OUTCOME OF HODGKIN LYMPHOMA PATIENTS IN CLINICAL ONCOLOGY DEPARTMENT IN AIN SHAMS UNIVERSITY HOSPITALS IN EGYPT.","authors":"Alaa-El-Dine H. Mahmoud, K. Abdelkarim, Khaled N. Abdelhakim, W. R. E. Ghamry, M. Hussein, D. E. D. Sherif","doi":"10.21608/asmj.2022.270222","DOIUrl":"https://doi.org/10.21608/asmj.2022.270222","url":null,"abstract":": Background: Lymphoma is the fourth most prevalent cancer among Egyptian adults, accounting for 76.6 percent non-Hodgkin lymphoma (NHL) and 23.4 percent Hodgkin lymphoma (HL). Most patients with classic Hodgkin lymphoma (cHL) achieve long-term survival free of HL, but late complications of treatment, such as second malignancies, cardiovascular disease, pulmonary disease, and other complications, have emerged as a competing cause of death and morbidity. Aim of the Work: The aim of this work is to analyse retrospectively epidemiological and clinical outcomes of Hodgkin lymphoma patients treated in Ain Shams University hospitals (clinical oncology department) in Egypt in the period from January 2017 till December 2020. Patients and Methods: This is a retrospective study that included 70 Hodgkin lymphoma patients who attended the lymphoma clinic at the Clinical Oncology Department, Ain Shams University. In the period between From January 2017 till December 2020. They either treated by chemotherapy only or chemotherapy and radiotherapy. Result: Overall, of the 70 patients in the present study, 7 patients (10 %) died, and sixty-three patients (90 %) are alive till the end of our follow-up. The median","PeriodicalId":7450,"journal":{"name":"Ain Shams Medical Journal","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90897480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-09-01DOI: 10.21608/asmj.2022.270250
S. Hady, Azza Youssef Ibrahim Ahmed, Hatem Saaed Abdel Hamid Neamat-Allah, Milad Ragaay Zekri Basta, Sanaa Mohamed Mohamed El Fawal
: Background: Lumbar Discectomy can be effectively performed using various anesthetic techniques. General anesthesia is more frequently used for these surgeries, though regional anesthesia when combined with general anesthesia is proven to be safe in few studies. Aim of the Work: To compare the intra operative and short term post-operative outcome variable in patients undergoing primary single level lumbar discectomy under combined caudal epidural with general anesthesia versus general anesthesia alone. Patients and Methods: This study included 100 patients aging 25 – 40 years old, admitted to operating room in Ain Shams University hospitals for single-level lumbar discectomy. The patients were divided into two groups of 50 each: Group A received general anesthesia, Group B, in addition to GA, received caudal epidural using 20 ml Bupivacaine 0.25% injected in the caudal region. Results: Intra operative HR, MAP, narcotic consumption, blood loss were lower in the Caudal Epidural with GA group. Postoperative 1 st analgesia needed was less in the GA group. Postoperative VAS score and PONV were higher in the GA group when compared to combined caudal epidural with GA. There was no motor affection in both groups and sensory affection was with a median at T10 in the group receiving Caudal epidural with GA. Conclusion: Epidural caudal anesthesia can safely be combined with GA for single leveled lumbar discectomy. It reduces intraoperative tachycardia and hypertension, blood loss, intraoperative and postoperative IV analgesic requirements and PONV.
{"title":"COMBINED CAUDAL EPIDURAL WITH GENERAL ANESTHESIA FOR LUMBAR DISCECTOMY","authors":"S. Hady, Azza Youssef Ibrahim Ahmed, Hatem Saaed Abdel Hamid Neamat-Allah, Milad Ragaay Zekri Basta, Sanaa Mohamed Mohamed El Fawal","doi":"10.21608/asmj.2022.270250","DOIUrl":"https://doi.org/10.21608/asmj.2022.270250","url":null,"abstract":": Background: Lumbar Discectomy can be effectively performed using various anesthetic techniques. General anesthesia is more frequently used for these surgeries, though regional anesthesia when combined with general anesthesia is proven to be safe in few studies. Aim of the Work: To compare the intra operative and short term post-operative outcome variable in patients undergoing primary single level lumbar discectomy under combined caudal epidural with general anesthesia versus general anesthesia alone. Patients and Methods: This study included 100 patients aging 25 – 40 years old, admitted to operating room in Ain Shams University hospitals for single-level lumbar discectomy. The patients were divided into two groups of 50 each: Group A received general anesthesia, Group B, in addition to GA, received caudal epidural using 20 ml Bupivacaine 0.25% injected in the caudal region. Results: Intra operative HR, MAP, narcotic consumption, blood loss were lower in the Caudal Epidural with GA group. Postoperative 1 st analgesia needed was less in the GA group. Postoperative VAS score and PONV were higher in the GA group when compared to combined caudal epidural with GA. There was no motor affection in both groups and sensory affection was with a median at T10 in the group receiving Caudal epidural with GA. Conclusion: Epidural caudal anesthesia can safely be combined with GA for single leveled lumbar discectomy. It reduces intraoperative tachycardia and hypertension, blood loss, intraoperative and postoperative IV analgesic requirements and PONV.","PeriodicalId":7450,"journal":{"name":"Ain Shams Medical Journal","volume":"17 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85515762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-09-01DOI: 10.21608/asmj.2022.270144
Emad R. Issak
: Background: Because of the emergence of the pandemic of SARS-Cov2 infection and the Global burden of COVID-19 on the worldwide healthcare systems, it became mandatory for all researchers to search for better preventive as well treatment strategies. Aim of the Work : The aim of the work is to study the effects of colchicine on the COVID-19 patients' clinical outcomes and the inflammatory markers during the disease. Material and Methods: This comparative, randomized controlled study has been conducted on patients confirmed to have COVID-19 attending Ain Shams Isolation hospital from Feb-2021 and May-2021. The A were randomized with 130 assigned to each group follows: The Study Group (colchicine group) (n=130): included patients who received COVID-19 treatment protocol plus colchicine according to the study protocol. The Control Group (n=130): included patients who received COVID-19 treatment protocol only without colchicine. Results : Both groups were comparable regarding age, BMI, and gender. Females constituted 58.1% & 56.0% of cases in the colchicine group & the control group, respectively. At presentation, as regards the severity, both groups are comparable (p = 0.553). In day 14, the improvement in the clinical status in the colchicine group 0.64 (0.96) is significantly (p-value = 0.002) higher than in the control group 0.28 (0.99). Conclusion : The beneficial effect of colchicine in COVID-19 cases is self-evident for both the clinical status and laboratory evaluation
{"title":"IMPACT OF COLCHICINE ON THE CLINICAL OUTCOME OF COVID-19","authors":"Emad R. Issak","doi":"10.21608/asmj.2022.270144","DOIUrl":"https://doi.org/10.21608/asmj.2022.270144","url":null,"abstract":": Background: Because of the emergence of the pandemic of SARS-Cov2 infection and the Global burden of COVID-19 on the worldwide healthcare systems, it became mandatory for all researchers to search for better preventive as well treatment strategies. Aim of the Work : The aim of the work is to study the effects of colchicine on the COVID-19 patients' clinical outcomes and the inflammatory markers during the disease. Material and Methods: This comparative, randomized controlled study has been conducted on patients confirmed to have COVID-19 attending Ain Shams Isolation hospital from Feb-2021 and May-2021. The A were randomized with 130 assigned to each group follows: The Study Group (colchicine group) (n=130): included patients who received COVID-19 treatment protocol plus colchicine according to the study protocol. The Control Group (n=130): included patients who received COVID-19 treatment protocol only without colchicine. Results : Both groups were comparable regarding age, BMI, and gender. Females constituted 58.1% & 56.0% of cases in the colchicine group & the control group, respectively. At presentation, as regards the severity, both groups are comparable (p = 0.553). In day 14, the improvement in the clinical status in the colchicine group 0.64 (0.96) is significantly (p-value = 0.002) higher than in the control group 0.28 (0.99). Conclusion : The beneficial effect of colchicine in COVID-19 cases is self-evident for both the clinical status and laboratory evaluation","PeriodicalId":7450,"journal":{"name":"Ain Shams Medical Journal","volume":"161 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85975070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-09-01DOI: 10.21608/asmj.2022.270237
Hassan Omar Siad Nur, Mohamed Mahfouz M. Omar, A. Mahmoud, E. Hefny, Mohammed Abdalmageed Alsayed Hamed, A. el-din, Abdalla Ali
: Background: Iatrogenic esophageal perforation accounts 60% of esophageal perforations and associated with 19% of mortality. Endoscopic procedures & invasive surgical maneuvers are the common causes. Pain, dysphagia and subcutaneous emphysema are common manifestations. Water soluble contrast study, CT scan, and endoscopy provide a high sensitivity for diagnosis. Early aggressive management within the first 24 hours is crucial for excellent outcomes; majority of patients is suitable for non-operative management while surgical intervention and esophageal stenting are alternative treatment options. Aim of the work: To compare efficacy of different management modalities in patients with iatrogenic esophageal perforations. Patient and Methods: Papers provided data from March 2007 to June 2022 related to patients with iatrogenic esophageal perforation & comparing different management modalities are reviewed between January 2021 and June 2022. We made pairwise meta-analyses of our outcomes using Comprehensive Meta-Analysis software (CMA version 3.9) . Event rate with the corresponding 95% confidence intervals (95%CI) was also being calculated for categorical data. Results: In majority of patients non-operative management is the best option with successful rate of more than 90% and lowest mortality (6.3%). Surgical management is warranted in the patients who do not meet the criteria for conservative treatment with successful rate of more than 80%. Esophageal stent is an alternative treatment option with 50 to 83% of esophageal healing. Conclusions: The treatment method still has to be chosen on an individual basis. We recommend conservative treatment when indicated. Extended perforations should be treated with a surgical approach and esophageal stenting have a satisfactory outcome in suitable patients. esophagus, iatrogenic, perforation, management, conservative, stent. Meta-analysis.
{"title":"COMPARATIVE STUDY BETWEEN DIFFERENT MANAGEMENT MODALITIES OF IATROGENIC ESOPHAGEAL PERFORATIONS","authors":"Hassan Omar Siad Nur, Mohamed Mahfouz M. Omar, A. Mahmoud, E. Hefny, Mohammed Abdalmageed Alsayed Hamed, A. el-din, Abdalla Ali","doi":"10.21608/asmj.2022.270237","DOIUrl":"https://doi.org/10.21608/asmj.2022.270237","url":null,"abstract":": Background: Iatrogenic esophageal perforation accounts 60% of esophageal perforations and associated with 19% of mortality. Endoscopic procedures & invasive surgical maneuvers are the common causes. Pain, dysphagia and subcutaneous emphysema are common manifestations. Water soluble contrast study, CT scan, and endoscopy provide a high sensitivity for diagnosis. Early aggressive management within the first 24 hours is crucial for excellent outcomes; majority of patients is suitable for non-operative management while surgical intervention and esophageal stenting are alternative treatment options. Aim of the work: To compare efficacy of different management modalities in patients with iatrogenic esophageal perforations. Patient and Methods: Papers provided data from March 2007 to June 2022 related to patients with iatrogenic esophageal perforation & comparing different management modalities are reviewed between January 2021 and June 2022. We made pairwise meta-analyses of our outcomes using Comprehensive Meta-Analysis software (CMA version 3.9) . Event rate with the corresponding 95% confidence intervals (95%CI) was also being calculated for categorical data. Results: In majority of patients non-operative management is the best option with successful rate of more than 90% and lowest mortality (6.3%). Surgical management is warranted in the patients who do not meet the criteria for conservative treatment with successful rate of more than 80%. Esophageal stent is an alternative treatment option with 50 to 83% of esophageal healing. Conclusions: The treatment method still has to be chosen on an individual basis. We recommend conservative treatment when indicated. Extended perforations should be treated with a surgical approach and esophageal stenting have a satisfactory outcome in suitable patients. esophagus, iatrogenic, perforation, management, conservative, stent. Meta-analysis.","PeriodicalId":7450,"journal":{"name":"Ain Shams Medical Journal","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82974550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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