Pub Date : 2023-06-01DOI: 10.21608/asmj.2023.307090
Esraa Mohamed, M. Fahmy, Shaimaa El-Diasty
Background: Among the most frequent causes of medical attention in the outpatient environment is knee pain or another knee condition. The capacity to guide percutaneous procedures and the fact that ultrasound may be performed anywhere, at any time, for a low price, and with excellent spatial resolution and image quality are all significant advantages of ultrasound. The patient may interact with the US machine in real time, allowing for quick clinical correlation and the opportunity and contrast the affected knee to the unaffected one. Structured assessment of the tendons, ligaments, joint space, osseous structures, peripheral nerves and vasculature, and the knee joint itself is possible by dividing the knee into anterior, medial, lateral, and posterior compartments. Aim of
{"title":"US OF THE KNEE: SCANNING TECHNIQUES, PITFALLS WITH CORRELATION TO COMMON PATHOLOGICAL CONDITIONS.","authors":"Esraa Mohamed, M. Fahmy, Shaimaa El-Diasty","doi":"10.21608/asmj.2023.307090","DOIUrl":"https://doi.org/10.21608/asmj.2023.307090","url":null,"abstract":"Background: Among the most frequent causes of medical attention in the outpatient environment is knee pain or another knee condition. The capacity to guide percutaneous procedures and the fact that ultrasound may be performed anywhere, at any time, for a low price, and with excellent spatial resolution and image quality are all significant advantages of ultrasound. The patient may interact with the US machine in real time, allowing for quick clinical correlation and the opportunity and contrast the affected knee to the unaffected one. Structured assessment of the tendons, ligaments, joint space, osseous structures, peripheral nerves and vasculature, and the knee joint itself is possible by dividing the knee into anterior, medial, lateral, and posterior compartments. Aim of","PeriodicalId":7450,"journal":{"name":"Ain Shams Medical Journal","volume":"70 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83753587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-01DOI: 10.21608/asmj.2023.307108
Khaled Ismaeil, Dina Abdelhakam, Iman Montasser, Perihan Kassem, Ramy Ahmed, Marium Fathi
: Background: Diagnosis of hepatocellular carcinoma (HCC) by liver biopsy can be challenging due to limited liver access and cirrhosis. Circulating tumor DNA (ctDNA) are genetic fragments originating from the tumor that circulate as a part of circulating free DNA and offer a representative sample of the tumor molecular profile. Aim of work: Our study aimed to investigate the role of TERT C228T promoter mutation in ctDNA as a diagnostic biomarker in Egyptian HCC patients. Methods: Our study is a case-control study that included 16 advanced HCC (AHCC), 12 early HCC (EHCC) cases, 10 chronic hepatitis C virus (HCV) patients as pathological control group and 10 healthy controls. Plasma was collected for genotyping of TERT C228T promoter mutation by real-time PCR. Results: All cases in our study including AHCC and EHCC patients as well as HCV pathological controls and healthy controls carried the wild TERT genotype. There was a significant difference of AST, ALT, total bilirubin and albumin between the different groups included in the study. Our study has also shown that AFP levels were significantly higher in AHCC patients when compared to EHCC patients. Conclusion: All studied samples in our study had the wild TERT genotype in ctDNA by real-time PCR. This could be attributed to the relatively small sample size of our study, and the relatively lower sensitivity of real-time PCR compared to other technologies such as droplet digital PCR (ddPCR) or next-generation sequencing. Future studies should include a larger sample size and utilize more sensitive technologies.
{"title":"TERT C228T MUTATION IN CIRCULATING TUMOR DNA AS A CLINICAL MARKER IN HEPATOCELLULAR CARCINOMA PATIENTS ATTENDING A TERTIARY HOSPITAL IN EGYPT: A CASE-CONTROL STUDY","authors":"Khaled Ismaeil, Dina Abdelhakam, Iman Montasser, Perihan Kassem, Ramy Ahmed, Marium Fathi","doi":"10.21608/asmj.2023.307108","DOIUrl":"https://doi.org/10.21608/asmj.2023.307108","url":null,"abstract":": Background: Diagnosis of hepatocellular carcinoma (HCC) by liver biopsy can be challenging due to limited liver access and cirrhosis. Circulating tumor DNA (ctDNA) are genetic fragments originating from the tumor that circulate as a part of circulating free DNA and offer a representative sample of the tumor molecular profile. Aim of work: Our study aimed to investigate the role of TERT C228T promoter mutation in ctDNA as a diagnostic biomarker in Egyptian HCC patients. Methods: Our study is a case-control study that included 16 advanced HCC (AHCC), 12 early HCC (EHCC) cases, 10 chronic hepatitis C virus (HCV) patients as pathological control group and 10 healthy controls. Plasma was collected for genotyping of TERT C228T promoter mutation by real-time PCR. Results: All cases in our study including AHCC and EHCC patients as well as HCV pathological controls and healthy controls carried the wild TERT genotype. There was a significant difference of AST, ALT, total bilirubin and albumin between the different groups included in the study. Our study has also shown that AFP levels were significantly higher in AHCC patients when compared to EHCC patients. Conclusion: All studied samples in our study had the wild TERT genotype in ctDNA by real-time PCR. This could be attributed to the relatively small sample size of our study, and the relatively lower sensitivity of real-time PCR compared to other technologies such as droplet digital PCR (ddPCR) or next-generation sequencing. Future studies should include a larger sample size and utilize more sensitive technologies.","PeriodicalId":7450,"journal":{"name":"Ain Shams Medical Journal","volume":"42 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90980908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-01DOI: 10.21608/asmj.2023.307093
Yasmin Elsaed, Naglaa Shebreya, S. Ragheb
: Background: Müllerian duct anomalies include a complex spectrum of anatomical anomalies that arise from deviations during the normal development of the Müllerian ducts. In paediatrics, such defects cannot present with any clinical symptoms before puberty, yet, they can also have obstructive symptoms or a mass effect due to presence of a non-communicating rudimentary horn or transverse vaginal septum. At the beginning of puberty, girls with these anomalies might have primary amenorrhea, pelvic pain or endometriosis. Müllerian duct anomalies have also associated with a variety of other congenital abnormalities. Aim of the work
{"title":"MRI IMAGING APPEARANCE IN MULLERIAN DUCT ANOMALIES.","authors":"Yasmin Elsaed, Naglaa Shebreya, S. Ragheb","doi":"10.21608/asmj.2023.307093","DOIUrl":"https://doi.org/10.21608/asmj.2023.307093","url":null,"abstract":": Background: Müllerian duct anomalies include a complex spectrum of anatomical anomalies that arise from deviations during the normal development of the Müllerian ducts. In paediatrics, such defects cannot present with any clinical symptoms before puberty, yet, they can also have obstructive symptoms or a mass effect due to presence of a non-communicating rudimentary horn or transverse vaginal septum. At the beginning of puberty, girls with these anomalies might have primary amenorrhea, pelvic pain or endometriosis. Müllerian duct anomalies have also associated with a variety of other congenital abnormalities. Aim of the work","PeriodicalId":7450,"journal":{"name":"Ain Shams Medical Journal","volume":"65 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86326991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-01DOI: 10.21608/asmj.2023.307113
Nourhan Nour Eldin Hassan, A. Nassar, Rasha El Kabarity, A. El-gendy
: Background: Coronavirus disease 2019 (COVID-19) is caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) infection. The origin of COVID-19 was reported in December 2019 in Wuhan, China, where cases of unknown pneumonia were reported. A novel coronavirus was obtained from these cases and was suggested as the cause of this outbreak. Aim of the Work: To detect presence or absence of auditory dysfunction and its type in COVID-19 patients. To investigate the possible site of lesion (up to the level of brain stem) in relation to COVID-19 infection. Patients and Methods: The present study was conducted on a total of forty-five subjects in Audiology Unit-Ain Shams University Specialized Hospital and El-Demerdash hospital. The study was performed on two groups: a study group consisted of 30 post COVID-19 patients with mean age of 34.80 + 9.81 years and a control group consisted of 15 normal hearing individuals without previous history of COVID-19 infection, their mean age was 32.80 + 8.28 years. Both study and control groups underwent basic audiological assessment (PTA, acoustic immitancemetry & acoustic reflex), TEOAEsand neuro-otologic ABR. Results: In the present study, Pure tone audiometry showed normal hearing in 28 (93.3 %) subjects of the study group subjects and documented mild high frequency sensorineural hearing loss in 2 (6.7%) subjects. Speech audiometry showed normal speech reception threshold and excellent speech discrimination in all subjects. Although the average of all frequencies was found within the normal limits in the hearing assessment of patients by PTA performed in patients who had COVID-19 and recovered, a significant higher thresholds was found, especially at 2, 4 and 8 KHz in comparison to the control group, Also there was significant lower (worse) TEOAEs signal to noise ratio (SNR) values at (2.8 and 4 KHz) in the study group in comparison to the control group and no significant difference between the study and control groups as regards low repetition rate & high repetition rate ABR parameters. Conclusion: In conclusion, pure tone audiometry and transient evoked oto-acoustic emissions were affected in subjects infected with COVID-19 specially at the high frequencies.
{"title":"EVALUATION OF COVID-19 IMPACT ON AUDITORY PATHWAY","authors":"Nourhan Nour Eldin Hassan, A. Nassar, Rasha El Kabarity, A. El-gendy","doi":"10.21608/asmj.2023.307113","DOIUrl":"https://doi.org/10.21608/asmj.2023.307113","url":null,"abstract":": Background: Coronavirus disease 2019 (COVID-19) is caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) infection. The origin of COVID-19 was reported in December 2019 in Wuhan, China, where cases of unknown pneumonia were reported. A novel coronavirus was obtained from these cases and was suggested as the cause of this outbreak. Aim of the Work: To detect presence or absence of auditory dysfunction and its type in COVID-19 patients. To investigate the possible site of lesion (up to the level of brain stem) in relation to COVID-19 infection. Patients and Methods: The present study was conducted on a total of forty-five subjects in Audiology Unit-Ain Shams University Specialized Hospital and El-Demerdash hospital. The study was performed on two groups: a study group consisted of 30 post COVID-19 patients with mean age of 34.80 + 9.81 years and a control group consisted of 15 normal hearing individuals without previous history of COVID-19 infection, their mean age was 32.80 + 8.28 years. Both study and control groups underwent basic audiological assessment (PTA, acoustic immitancemetry & acoustic reflex), TEOAEsand neuro-otologic ABR. Results: In the present study, Pure tone audiometry showed normal hearing in 28 (93.3 %) subjects of the study group subjects and documented mild high frequency sensorineural hearing loss in 2 (6.7%) subjects. Speech audiometry showed normal speech reception threshold and excellent speech discrimination in all subjects. Although the average of all frequencies was found within the normal limits in the hearing assessment of patients by PTA performed in patients who had COVID-19 and recovered, a significant higher thresholds was found, especially at 2, 4 and 8 KHz in comparison to the control group, Also there was significant lower (worse) TEOAEs signal to noise ratio (SNR) values at (2.8 and 4 KHz) in the study group in comparison to the control group and no significant difference between the study and control groups as regards low repetition rate & high repetition rate ABR parameters. Conclusion: In conclusion, pure tone audiometry and transient evoked oto-acoustic emissions were affected in subjects infected with COVID-19 specially at the high frequencies.","PeriodicalId":7450,"journal":{"name":"Ain Shams Medical Journal","volume":"112 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85488451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-01DOI: 10.21608/asmj.2023.307120
M. Mohammed, Mohammed Al werdany, Shafik Tahseen El Molla, A. Farghaly, O. Ahmed
: Background and Objectives : Degenerative spondylolisthesis is frequently associated with LBP and leg pain. When conservative treatment fails to relief symptoms, the surgical spine fixation and neural tissue decompression becomes the treatment of choice as it leads to functional and symptomatic improvement. In this study we compare between percutaneous spine fixations versus open spine fixation in cases of degenerative spondylolisthesis. Patients and Methods : 40 patients with degenerative spondylolisthesis were divided randomly and equally in two groups, group A of patients underwent spine fixation with conventional open surgery approach, while group B underwent percutaneous spine fixation, we recorded intraoperative difficulties and post-operative outcome in the two groups every 6 months for 18 months. Results : The mean operation time was 174 minutes in group A and 168 minutes in group B, the mean amount of blood loss in group A was 443 ml, while was 165 ml in group B (p value < 0.001), the mean duration of hospital stay in group A was 2.45 days, while it was 1.8 day in group B (p value <0.002), there is no statistically significant difference between the two groups in reduction of leg pain, back pain and ODI either immediately post-operative or after 6, 12, and 18 months of follow up Conclusions : Percutaneous spine fixation has the advantage of being less invasive, with less intra operative bleeding, less operation time and post-operative hospital stay than the conventional open spine fixation technique. However, both techniques have the same results of improving patients’ leg and back pain on the long term.
{"title":"PERCUTANEOUS VERSUS OPEN SURGICAL FIXATION OF LUMBOSACRAL SPINE IN CASES OF DEGENERATIVE SPONDYLOLISTHESIS","authors":"M. Mohammed, Mohammed Al werdany, Shafik Tahseen El Molla, A. Farghaly, O. Ahmed","doi":"10.21608/asmj.2023.307120","DOIUrl":"https://doi.org/10.21608/asmj.2023.307120","url":null,"abstract":": Background and Objectives : Degenerative spondylolisthesis is frequently associated with LBP and leg pain. When conservative treatment fails to relief symptoms, the surgical spine fixation and neural tissue decompression becomes the treatment of choice as it leads to functional and symptomatic improvement. In this study we compare between percutaneous spine fixations versus open spine fixation in cases of degenerative spondylolisthesis. Patients and Methods : 40 patients with degenerative spondylolisthesis were divided randomly and equally in two groups, group A of patients underwent spine fixation with conventional open surgery approach, while group B underwent percutaneous spine fixation, we recorded intraoperative difficulties and post-operative outcome in the two groups every 6 months for 18 months. Results : The mean operation time was 174 minutes in group A and 168 minutes in group B, the mean amount of blood loss in group A was 443 ml, while was 165 ml in group B (p value < 0.001), the mean duration of hospital stay in group A was 2.45 days, while it was 1.8 day in group B (p value <0.002), there is no statistically significant difference between the two groups in reduction of leg pain, back pain and ODI either immediately post-operative or after 6, 12, and 18 months of follow up Conclusions : Percutaneous spine fixation has the advantage of being less invasive, with less intra operative bleeding, less operation time and post-operative hospital stay than the conventional open spine fixation technique. However, both techniques have the same results of improving patients’ leg and back pain on the long term.","PeriodicalId":7450,"journal":{"name":"Ain Shams Medical Journal","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86409511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-01DOI: 10.21608/asmj.2023.307126
Alshymaa Farouk, S. Abdel Rahman, Menna Allah Zakareya Abou Elwafa, F. Aboud
: Background : Inflammatory changes in rheumatological diseases encompass alterations in shape, number, and size of peripheral blood cells. Complete blood cell parameters may be used as an index of inflammation and disease activity. Aim of the work: Assess the hematological parameters in rheumatoid arthritis (RA) and identify their relationship with disease activity. Methods : 141 patients with rheumatoid arthritis and 100 healthy controls were included in this study. Full medical history, general and musculoskeletal examination, assessment of disease activity using the DAS 28 score, markers of inflammation, rheumatoid factor (RF) titer, anti-cyclic citrullinated peptide (anti-CCP) titer and complete blood picture were done. Results : RA patients had lower RBCs, Hb, MPV, PWD and Hb/RDW% ratio and higher RDW% than controls. Active RA patients had higher WBCs, neutrophils, and NLR. WBCs and neutrophils were positively correlated with DAS score and CRP titre. NLR ratio correlated positively with the DAS score, CRP and Anti CCP titres. Active RA had higher RDW% and lower HCT, Hb, Hb/PLT, RDW%/PLT, Hb/RDW% ratios. RDW% was positively correlated with DAS score, ESR, CRP, RF and Anti CCP titres. The RDW% differentiated active and inactive RA with best cut-off value >12. Active patients had higher platelets and PLR, which were positively correlated with DAS score . Conclusion : Changes in haematological parameters are significantly associated with disease activity in RA patients and they correlate positively with inflammatory markers.
{"title":"HEMATOLOGICAL PARAMETERS IN RHEUMATOID ARTHRITIS AND THEIR RELATIONSHIP WITH DISEASE ACTIVITY","authors":"Alshymaa Farouk, S. Abdel Rahman, Menna Allah Zakareya Abou Elwafa, F. Aboud","doi":"10.21608/asmj.2023.307126","DOIUrl":"https://doi.org/10.21608/asmj.2023.307126","url":null,"abstract":": Background : Inflammatory changes in rheumatological diseases encompass alterations in shape, number, and size of peripheral blood cells. Complete blood cell parameters may be used as an index of inflammation and disease activity. Aim of the work: Assess the hematological parameters in rheumatoid arthritis (RA) and identify their relationship with disease activity. Methods : 141 patients with rheumatoid arthritis and 100 healthy controls were included in this study. Full medical history, general and musculoskeletal examination, assessment of disease activity using the DAS 28 score, markers of inflammation, rheumatoid factor (RF) titer, anti-cyclic citrullinated peptide (anti-CCP) titer and complete blood picture were done. Results : RA patients had lower RBCs, Hb, MPV, PWD and Hb/RDW% ratio and higher RDW% than controls. Active RA patients had higher WBCs, neutrophils, and NLR. WBCs and neutrophils were positively correlated with DAS score and CRP titre. NLR ratio correlated positively with the DAS score, CRP and Anti CCP titres. Active RA had higher RDW% and lower HCT, Hb, Hb/PLT, RDW%/PLT, Hb/RDW% ratios. RDW% was positively correlated with DAS score, ESR, CRP, RF and Anti CCP titres. The RDW% differentiated active and inactive RA with best cut-off value >12. Active patients had higher platelets and PLR, which were positively correlated with DAS score . Conclusion : Changes in haematological parameters are significantly associated with disease activity in RA patients and they correlate positively with inflammatory markers.","PeriodicalId":7450,"journal":{"name":"Ain Shams Medical Journal","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89809360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-01DOI: 10.21608/asmj.2023.307111
Dina E Rizk, Mohamed Mahmoud, S. Saber, Yasmeen Ibraheem
Background and study aim: The current study aims to figure out the use of the serological 1, 3 Beta-D -Glucan (BDG) test for early detection of Pneumocystis jirovecii Pneumonia (PcP) among immuno - compromised patients with acute respiratory distress syndrome (ARDS). Patients and methods: This are a cross-sectional study. It was carried out at Ain Shams University Hospitals on immunocompromised patients presenting with pneumonia. The study included 44 clinically relevant patients, with lower respiratory tract infections, based on their clinical presentation and chest radiological findings. The group included 26 males and 18 females. Their ages ranged from 1 to 74 years. Results: Out of 44 immunocompromised Patients with ARDS caused by Invasive Fungal Infections (IFI) suspected PcP according to clinical, radiological findings and Galactomannan, those patients included patients in ICU, with haematological malignancies, on immunosuppressive drugs and HIV positive Patients. 72.7 % were positive for BDG, while 27.3 % were negative for BDG. Positive predictive value of BDG was 75 % while BDG’s negative predictive value 91.7 %. Our results figured out also that there was a statistically significant relation between results of BDG and Galactomannan with Value < 0.001, lymphocytic count with P Value 0.005 and LDH level with P Value 0.017. Sensitivity of the test was 96% while Specificity was 57.9% Conclusions: Pneumocystis jirovecii pneumonia represents a huge burden to immunocompromised patients in the intensive care unit (ICU) and those with haematological malignancies, particularly those with lymphoproliferative diseases. Increased rates of ICU admissions for respiratory failure and fatalities are linked to the disease. BDG is a non-invasive diagnostic technique that has a high negative predictive value and can rule out IFI. However, neither do its serum levels accurately reflect the severity of the illness nor are they useful for gauging treatment effectiveness.
背景与研究目的:本研究旨在探讨1,3 β - d -葡聚糖(BDG)血清学检测在急性呼吸窘迫综合征(ARDS)免疫功能低下患者中早期检测吉罗氏肺囊虫肺炎(PcP)的应用价值。患者和方法:这是一项横断面研究。它是在艾因沙姆斯大学医院对出现肺炎的免疫功能低下患者进行的。根据临床表现和胸部影像学表现，本研究纳入了44例临床相关的下呼吸道感染患者。该小组包括26名男性和18名女性。他们的年龄从1岁到74岁不等。结果:44例经临床、影像学及半乳甘露annan检查证实为侵袭性真菌感染(IFI)所致的ARDS患者中，包括ICU患者、血液系统恶性肿瘤患者、免疫抑制药物患者和HIV阳性患者，BDG阳性占72.7%，阴性占27.3%。BDG阳性预测值为75%，阴性预测值为91.7%。我们的结果还发现，BDG和半乳甘露聚糖的结果(P值< 0.001)、淋巴细胞计数(P值0.005)和LDH水平(P值0.017)之间存在统计学意义。结论:耶氏肺囊虫肺炎对重症监护病房(ICU)免疫功能低下患者和血液系统恶性肿瘤患者，特别是淋巴细胞增生性疾病患者是一个巨大的负担。因呼吸衰竭和死亡而入院ICU的比率增加与该疾病有关。BDG是一种非侵入性诊断技术，具有较高的阴性预测值，可排除IFI。然而，它的血清水平既不能准确反映疾病的严重程度，也不能用于衡量治疗效果。
{"title":"USEFULNESS OF SERUM (1, 3) BETA D GLUCAN IN DIAGNOSIS OF PNEUMOCYSTIS JIROVECII PNEUMONIA IN IMMUNOCOMPROMISED PATIENTS","authors":"Dina E Rizk, Mohamed Mahmoud, S. Saber, Yasmeen Ibraheem","doi":"10.21608/asmj.2023.307111","DOIUrl":"https://doi.org/10.21608/asmj.2023.307111","url":null,"abstract":"Background and study aim: The current study aims to figure out the use of the serological 1, 3 Beta-D -Glucan (BDG) test for early detection of Pneumocystis jirovecii Pneumonia (PcP) among immuno - compromised patients with acute respiratory distress syndrome (ARDS). Patients and methods: This are a cross-sectional study. It was carried out at Ain Shams University Hospitals on immunocompromised patients presenting with pneumonia. The study included 44 clinically relevant patients, with lower respiratory tract infections, based on their clinical presentation and chest radiological findings. The group included 26 males and 18 females. Their ages ranged from 1 to 74 years. Results: Out of 44 immunocompromised Patients with ARDS caused by Invasive Fungal Infections (IFI) suspected PcP according to clinical, radiological findings and Galactomannan, those patients included patients in ICU, with haematological malignancies, on immunosuppressive drugs and HIV positive Patients. 72.7 % were positive for BDG, while 27.3 % were negative for BDG. Positive predictive value of BDG was 75 % while BDG’s negative predictive value 91.7 %. Our results figured out also that there was a statistically significant relation between results of BDG and Galactomannan with Value < 0.001, lymphocytic count with P Value 0.005 and LDH level with P Value 0.017. Sensitivity of the test was 96% while Specificity was 57.9% Conclusions: Pneumocystis jirovecii pneumonia represents a huge burden to immunocompromised patients in the intensive care unit (ICU) and those with haematological malignancies, particularly those with lymphoproliferative diseases. Increased rates of ICU admissions for respiratory failure and fatalities are linked to the disease. BDG is a non-invasive diagnostic technique that has a high negative predictive value and can rule out IFI. However, neither do its serum levels accurately reflect the severity of the illness nor are they useful for gauging treatment effectiveness.","PeriodicalId":7450,"journal":{"name":"Ain Shams Medical Journal","volume":"20 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79246188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-01DOI: 10.21608/asmj.2023.307135
Waleed el-sorougi, Sarah Lawendy, M. Soliman, A. Hasanien
: Background: Asthma affects 1–18% of the population in different countries. Its prevalence varies worldwide but more than 5% of any investigated population suffer from asthma. The effect of asthma on sexual function of these patients is still not clear. Aim of the Work: This work aims to assess the relation between asthma and erectile dysfunction, and if there is any relation between the degree of asthma severity and the severity of erectile dysfunction. Patients and Methods : Our study was conducted on two groups: Group A includes 120 male asthmatic patients who were enrolled consecutively from the patients attending outpatient clinics of Helwan University hospitals and Abassya Chest diseases Hospital and group B (the control group) including 100 healthy volunteers. Results: It was found that asthmatic patients included in the current study had lower International Index of Erectile Function 5 (IIEF-5) scores than the controls. Also, we found that most of cases of moderate asthma had mild erectile dysfunction (73.2%) and only 8.5% had mild to moderate erectile dysfunction. While most of those with severe asthma, 39.5% had mild ED and 31.6% had mild to moderate ED Conclusions: Patients with asthma have a higher prevalence of erectile dysfunction. Education level, occupational status, asthma duration, asthma severity and control level were independent risk factors for sexual dysfunction and poor quality of life. Therefore, to improve the quality of life, patients with asthma should be evaluated holistically, their sexual functions should be taken into account and multidisciplinary approaches should be applied.
{"title":"MALE SEXUAL DYSFUNCTION AMONG ASTHMATIC PATIENTS. A CROSS SECTIONAL STUDY","authors":"Waleed el-sorougi, Sarah Lawendy, M. Soliman, A. Hasanien","doi":"10.21608/asmj.2023.307135","DOIUrl":"https://doi.org/10.21608/asmj.2023.307135","url":null,"abstract":": Background: Asthma affects 1–18% of the population in different countries. Its prevalence varies worldwide but more than 5% of any investigated population suffer from asthma. The effect of asthma on sexual function of these patients is still not clear. Aim of the Work: This work aims to assess the relation between asthma and erectile dysfunction, and if there is any relation between the degree of asthma severity and the severity of erectile dysfunction. Patients and Methods : Our study was conducted on two groups: Group A includes 120 male asthmatic patients who were enrolled consecutively from the patients attending outpatient clinics of Helwan University hospitals and Abassya Chest diseases Hospital and group B (the control group) including 100 healthy volunteers. Results: It was found that asthmatic patients included in the current study had lower International Index of Erectile Function 5 (IIEF-5) scores than the controls. Also, we found that most of cases of moderate asthma had mild erectile dysfunction (73.2%) and only 8.5% had mild to moderate erectile dysfunction. While most of those with severe asthma, 39.5% had mild ED and 31.6% had mild to moderate ED Conclusions: Patients with asthma have a higher prevalence of erectile dysfunction. Education level, occupational status, asthma duration, asthma severity and control level were independent risk factors for sexual dysfunction and poor quality of life. Therefore, to improve the quality of life, patients with asthma should be evaluated holistically, their sexual functions should be taken into account and multidisciplinary approaches should be applied.","PeriodicalId":7450,"journal":{"name":"Ain Shams Medical Journal","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74396815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-01DOI: 10.21608/asmj.2023.307119
M. Abdelfatah, Abdelrahman El Gayar, Aly Ibrahim, Sameh Hefny
: Background : The recognized surgical procedures for cervical spondylotic myelopathy (CSM) include anterior cervical discectomy and fusion (ACDF) and anterior cervical corpectomy and fusion (ACCF). The best surgical technique for double-level CSM is still up for debate, though. Aim of the study: This study aimed to evaluate the postoperative clinical and radiological outcomes of the CSM patients who underwent two adjacent cervical discectomies versus a single-level corpectomy. Patients and Methods: In this retrospective cohort study, we reviewed the medical records of patients with double-level CSM at our university hospital. We included the data of the patients who underwent two adjacent ACDFs (group A) and the patients who underwent a single-level ACCF (group B) from January 2015 to December 2020. Thirty-five patients met our selection criteria. The functional impairment was assessed using the Nurick grades. Results: The study groups were similar in age, gender, and comorbidities. The mean operative time and the intraoperative blood loss were significantly lower in the ACDF group. There were no statistically significant differences in the clinical outcome of both groups. Also, there were no statistically significant differences between the two groups regarding the one-year incidence of bony fusion, the improvement in the degree of canal stenosis, or Cobb’s angle. In addition, the postoperative complications were similar between groups. Conclusions: From our results, we cannot recommend one procedure over the other for treating double-level CSM. However, ACDF carries a significantly shorter operative time with less blood loss than the ACCF procedure.
{"title":"CERVICAL CORPECTOMY VERSUS TWO-LEVEL ANTERIOR DISCECTOMY FOR DOUBLE-LEVEL CERVICAL SPONDYLOTIC MYELOPATHY","authors":"M. Abdelfatah, Abdelrahman El Gayar, Aly Ibrahim, Sameh Hefny","doi":"10.21608/asmj.2023.307119","DOIUrl":"https://doi.org/10.21608/asmj.2023.307119","url":null,"abstract":": Background : The recognized surgical procedures for cervical spondylotic myelopathy (CSM) include anterior cervical discectomy and fusion (ACDF) and anterior cervical corpectomy and fusion (ACCF). The best surgical technique for double-level CSM is still up for debate, though. Aim of the study: This study aimed to evaluate the postoperative clinical and radiological outcomes of the CSM patients who underwent two adjacent cervical discectomies versus a single-level corpectomy. Patients and Methods: In this retrospective cohort study, we reviewed the medical records of patients with double-level CSM at our university hospital. We included the data of the patients who underwent two adjacent ACDFs (group A) and the patients who underwent a single-level ACCF (group B) from January 2015 to December 2020. Thirty-five patients met our selection criteria. The functional impairment was assessed using the Nurick grades. Results: The study groups were similar in age, gender, and comorbidities. The mean operative time and the intraoperative blood loss were significantly lower in the ACDF group. There were no statistically significant differences in the clinical outcome of both groups. Also, there were no statistically significant differences between the two groups regarding the one-year incidence of bony fusion, the improvement in the degree of canal stenosis, or Cobb’s angle. In addition, the postoperative complications were similar between groups. Conclusions: From our results, we cannot recommend one procedure over the other for treating double-level CSM. However, ACDF carries a significantly shorter operative time with less blood loss than the ACCF procedure.","PeriodicalId":7450,"journal":{"name":"Ain Shams Medical Journal","volume":"13 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82405309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-01DOI: 10.21608/asmj.2023.307115
M. Abd elhameed, N. Kamal, Ghada Khalil, Maha Bushnaq
: Background: Cochlear implantation is the standard treatment for the severe to profound bilateral sensorineural hearing loss. Candidacy criteria have expanded gradually due to technological developments and increasing experience. Main expansions include very young age, residual hearing, additional handicaps & special etiologies of deafness. Aim of the work: To compare the outcomes of children with bilateral severe to profound SNHL with cochlear implant versus children with severe SNHL with hearing aids. Patient and Methods : 60 children with age 5-15 years divided into 2 groups were included in the present study. Group I: 30 binaural HA users with bilateral severe sensorineural hearing loss. Group II: 30 CI users with bilateral severe to profound hearing loss. Test battery of outcome measures (Arabic versions) were done to evaluate and compare outcome of both groups including measures for: audibility, aided speech recognition test using PBKG lists, perception of everyday sounds by MAIS questionnaire and language assessment using PLS 4 test. Results: Results showed that HA group scored better than CI group in aided speech recognition test by PBKG lists, MAIS questionnaire and PLS 4 test. CI group got better aided thresholds. Conclusion: Children with severe hearing loss using hearing aids have the potential to receive sufficient auditory information from conventional hearing aids to acquire age-appropriate spoken communication.
{"title":"OUTCOME MEASURES OF COCHLEAR IMPLANT RECIPIENTS VERSUS HEARING AID USERS IN SEVERE SENSORINEURAL HEARING LOSS AMONG EGYPTIAN CHILDREN.","authors":"M. Abd elhameed, N. Kamal, Ghada Khalil, Maha Bushnaq","doi":"10.21608/asmj.2023.307115","DOIUrl":"https://doi.org/10.21608/asmj.2023.307115","url":null,"abstract":": Background: Cochlear implantation is the standard treatment for the severe to profound bilateral sensorineural hearing loss. Candidacy criteria have expanded gradually due to technological developments and increasing experience. Main expansions include very young age, residual hearing, additional handicaps & special etiologies of deafness. Aim of the work: To compare the outcomes of children with bilateral severe to profound SNHL with cochlear implant versus children with severe SNHL with hearing aids. Patient and Methods : 60 children with age 5-15 years divided into 2 groups were included in the present study. Group I: 30 binaural HA users with bilateral severe sensorineural hearing loss. Group II: 30 CI users with bilateral severe to profound hearing loss. Test battery of outcome measures (Arabic versions) were done to evaluate and compare outcome of both groups including measures for: audibility, aided speech recognition test using PBKG lists, perception of everyday sounds by MAIS questionnaire and language assessment using PLS 4 test. Results: Results showed that HA group scored better than CI group in aided speech recognition test by PBKG lists, MAIS questionnaire and PLS 4 test. CI group got better aided thresholds. Conclusion: Children with severe hearing loss using hearing aids have the potential to receive sufficient auditory information from conventional hearing aids to acquire age-appropriate spoken communication.","PeriodicalId":7450,"journal":{"name":"Ain Shams Medical Journal","volume":"231 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82749949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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