Pub Date : 2024-01-01DOI: 10.1016/j.rgmxen.2023.02.002
R. Montalvo-Otivo , P. Vilcapoma , A. Murillo , C. Mathey , A. Olivera , G. Veliz , D. Estrella
Introduction
The treatment and diagnosis of chronic diarrhea in the immunocompromised patient depends on the ability to rapidly detect the etiologic agents.
Aims
Our aim was to evaluate the results of the FilmArray® gastrointestinal panel in patients newly diagnosed with HIV infection that presented with chronic diarrhea.
Material and methods
Utilizing nonprobability consecutive convenience sampling, 24 patients were included that underwent molecular testing for the simultaneous detection of 22 pathogens.
Results
In 24 HIV-infected patients with chronic diarrhea, enteropathogen bacteria were detected in 69% of the cases, parasites in 18%, and viruses in 13%. Enteropathogenic Escherichia coli and enteroaggregative Escherichia coli were the main bacteria identified, Giardia lamblia was found in 25%, and norovirus was the most frequent viral agent. The median number of infectious agents per patient was three (range of 0 to 7). The biologic agents not identified through the FilmArray® method were tuberculosis and fungi.
Conclusions
Several infectious agents were simultaneously detected through the FilmArray® gastrointestinal panel in patients with HIV infection and chronic diarrhea.
{"title":"Evaluation of chronic diarrhea in patients newly diagnosed with HIV infection through the FilmArray® gastrointestinal panel","authors":"R. Montalvo-Otivo , P. Vilcapoma , A. Murillo , C. Mathey , A. Olivera , G. Veliz , D. Estrella","doi":"10.1016/j.rgmxen.2023.02.002","DOIUrl":"10.1016/j.rgmxen.2023.02.002","url":null,"abstract":"<div><h3>Introduction</h3><p>The treatment and diagnosis of chronic diarrhea in the immunocompromised patient depends on the ability to rapidly detect the etiologic agents.</p></div><div><h3>Aims</h3><p>Our aim was to evaluate the results of the FilmArray® gastrointestinal panel in patients newly diagnosed with HIV infection that presented with chronic diarrhea.</p></div><div><h3>Material and methods</h3><p>Utilizing nonprobability consecutive convenience sampling, 24 patients were included that underwent molecular testing for the simultaneous detection of 22 pathogens.</p></div><div><h3>Results</h3><p>In 24 HIV-infected patients with chronic diarrhea, enteropathogen bacteria were detected in 69% of the cases, parasites in 18%, and viruses in 13%. Enteropathogenic <em>Escherichia coli</em> and enteroaggregative <em>Escherichia coli</em> were the main bacteria identified, <em>Giardia lamblia</em> was found in 25%, and norovirus was the most frequent viral agent. The median number of infectious agents per patient was three (range of 0 to 7). The biologic agents not identified through the FilmArray® method were tuberculosis and fungi.</p></div><div><h3>Conclusions</h3><p>Several infectious agents were simultaneously detected through the FilmArray® gastrointestinal panel in patients with HIV infection and chronic diarrhea.</p></div>","PeriodicalId":74705,"journal":{"name":"Revista de gastroenterologia de Mexico (English)","volume":"89 1","pages":"Pages 80-88"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2255534X2300021X/pdfft?md5=55e58bfb82adf6c42ce53f4552dd8dfc&pid=1-s2.0-S2255534X2300021X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9085405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-01DOI: 10.1016/j.rgmxen.2023.05.012
J.A. Castrillón-Lozano , J.S. Arturo-Abadía , J.J. Acosta-Velásquez
{"title":"Factors associated with management and negative outcomes of esophageal perforation","authors":"J.A. Castrillón-Lozano , J.S. Arturo-Abadía , J.J. Acosta-Velásquez","doi":"10.1016/j.rgmxen.2023.05.012","DOIUrl":"10.1016/j.rgmxen.2023.05.012","url":null,"abstract":"","PeriodicalId":74705,"journal":{"name":"Revista de gastroenterologia de Mexico (English)","volume":"89 1","pages":"Page 172"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2255534X24000033/pdfft?md5=e1859533abbc4f060a0bfbc3675fb647&pid=1-s2.0-S2255534X24000033-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140112400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-01DOI: 10.1016/j.rgmxen.2023.10.002
O.V. Hernández Mondragón, J.G. Ferral Mejía
{"title":"Endoscopic closure of an esophagobronchial fistula after per oral endoscopic myotomy through the combination of endoscopic submucosal dissection and hemoclips","authors":"O.V. Hernández Mondragón, J.G. Ferral Mejía","doi":"10.1016/j.rgmxen.2023.10.002","DOIUrl":"10.1016/j.rgmxen.2023.10.002","url":null,"abstract":"","PeriodicalId":74705,"journal":{"name":"Revista de gastroenterologia de Mexico (English)","volume":"89 1","pages":"Pages 167-169"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2255534X24000070/pdfft?md5=81f128142f03acc2c7d8e86161e509cb&pid=1-s2.0-S2255534X24000070-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140133468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-01DOI: 10.1016/j.rgmxen.2023.07.006
G. Claudio-Pombosa, I. Sisa
{"title":"Comments on the article: «Indocyanine green fluorescence angiography in colorectal surgery: A retrospective case-control analysis in Mexico»","authors":"G. Claudio-Pombosa, I. Sisa","doi":"10.1016/j.rgmxen.2023.07.006","DOIUrl":"10.1016/j.rgmxen.2023.07.006","url":null,"abstract":"","PeriodicalId":74705,"journal":{"name":"Revista de gastroenterologia de Mexico (English)","volume":"89 1","pages":"Page 170"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2255534X24000021/pdfft?md5=bd39ecfa574fc9a6683febd6ce8e7998&pid=1-s2.0-S2255534X24000021-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140112399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-01DOI: 10.1016/j.rgmxen.2023.04.001
C.E. Builes-Montaño , E. Pérez-Giraldo , S. Castro-Sánchez , N.A. Rojas-Henao , O.M. Santos-Sánchez , J.C. Restrepo-Gutiérrez
Background and aims
The relationship between obesity and nonalcoholic fatty liver disease (NAFLD) has long been established, and the prevalence of both conditions has grown together. Recent interest in NAFLD in nonobese individuals has led to an increasing number of studies, especially in Asia. Despite the fact that the prevalence of NAFLD in Latin America is one of the highest in the world, there is a lack of information on lean NAFLD populations from the region. The aim of the present study was to assess the risk of metabolic comorbidities across the whole body mass index spectrum when nonalcoholic steatohepatitis (NASH) was first diagnosed in a Latin American population.
Methods
A single-center, cross-sectional study on Colombian patients newly diagnosed with NAFLD, within the time frame of 2010–2020, compared their metabolic biochemical profile, liver enzymes, risk of prevalent metabolic abnormalities, and liver disease.
Results
Data from 300 patients were collected. Ninety-two percent of the patients were men and the median patient age was 47 (IQR 20) years. We found no significant differences in the biochemical, metabolic profile, or liver enzyme plasma concentration between lean, overweight, and obese individuals. Obese patients had significantly higher LDL cholesterol, and a higher risk of dyslipidemia (OR 1.86, 95% CI 1.14–3.05). Every 1 kg increase in body weight increased the risk of having NASH by 2% (95% CI 2–4).
Conclusions
We evaluated the metabolic risk across the entire body mass index spectrum in a Colombian cohort with NAFLD and presented the characteristics of what we believe is the first Latin American lean NAFLD population to be described.
背景和目的肥胖与非酒精性脂肪肝（NAFLD）之间的关系早已确立，这两种疾病的发病率也在同时增长。近年来，人们对非肥胖人群的非酒精性脂肪肝的研究越来越多，尤其是在亚洲。尽管非酒精性脂肪肝在拉丁美洲的发病率位居世界前列，但该地区却缺乏有关非酒精性脂肪肝瘦弱人群的资料。本研究旨在评估拉丁美洲人群首次诊断出非酒精性脂肪性肝炎（NASH）时，在整个体重指数范围内发生代谢合并症的风险。结果 收集了 300 名患者的数据。92%的患者为男性，患者年龄中位数为 47 岁（IQR 20）。我们发现，瘦人、超重人和肥胖人的生化指标、代谢特征或肝酶血浆浓度没有明显差异。肥胖患者的低密度脂蛋白胆固醇明显更高，血脂异常的风险也更高（OR 1.86，95% CI 1.14-3.05）。结论我们评估了哥伦比亚非酒精性脂肪肝患者队列中整个体重指数范围内的代谢风险，并介绍了我们认为是拉丁美洲第一个被描述的瘦非酒精性脂肪肝人群的特征。
{"title":"Metabolic disorders across the body mass index spectrum in a Colombian population with nonalcoholic fatty liver disease","authors":"C.E. Builes-Montaño , E. Pérez-Giraldo , S. Castro-Sánchez , N.A. Rojas-Henao , O.M. Santos-Sánchez , J.C. Restrepo-Gutiérrez","doi":"10.1016/j.rgmxen.2023.04.001","DOIUrl":"10.1016/j.rgmxen.2023.04.001","url":null,"abstract":"<div><h3>Background and aims</h3><p>The relationship between obesity and nonalcoholic fatty liver disease (NAFLD) has long been established, and the prevalence of both conditions has grown together. Recent interest in NAFLD in nonobese individuals has led to an increasing number of studies, especially in Asia. Despite the fact that the prevalence of NAFLD in Latin America is one of the highest in the world, there is a lack of information on lean NAFLD populations from the region. The aim of the present study was to assess the risk of metabolic comorbidities across the whole body mass index spectrum when nonalcoholic steatohepatitis (NASH) was first diagnosed in a Latin American population.</p></div><div><h3>Methods</h3><p>A single-center, cross-sectional study on Colombian patients newly diagnosed with NAFLD, within the time frame of 2010–2020, compared their metabolic biochemical profile, liver enzymes, risk of prevalent metabolic abnormalities, and liver disease.</p></div><div><h3>Results</h3><p>Data from 300 patients were collected. Ninety-two percent of the patients were men and the median patient age was 47 (IQR 20) years. We found no significant differences in the biochemical, metabolic profile, or liver enzyme plasma concentration between lean, overweight, and obese individuals. Obese patients had significantly higher LDL cholesterol, and a higher risk of dyslipidemia (OR 1.86, 95% CI 1.14–3.05). Every 1<!--> <!-->kg increase in body weight increased the risk of having NASH by 2% (95% CI 2–4).</p></div><div><h3>Conclusions</h3><p>We evaluated the metabolic risk across the entire body mass index spectrum in a Colombian cohort with NAFLD and presented the characteristics of what we believe is the first Latin American lean NAFLD population to be described.</p></div>","PeriodicalId":74705,"journal":{"name":"Revista de gastroenterologia de Mexico (English)","volume":"89 1","pages":"Pages 64-69"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2255534X23000300/pdfft?md5=de35fba0af894657346fbaf8ae007061&pid=1-s2.0-S2255534X23000300-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9792068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-01DOI: 10.1016/j.rgmxen.2023.03.002
S. Nasr, A. Khsiba, L. Hamzaoui, M. Mahmoudi, A. Ben-Mohamed, M. Yaakoubi, M. Medhioub, M. Azzouz
Introduction
Gastrointestinal angiodysplasia (GIAD) is the most common vascular anomaly in the gastrointestinal (GI) tract, yet little is known about the factors favoring their bleeding. Our study aim was to determine the characteristics of patients with GIAD lesions in a Tunisian population and identify the risk factors of bleeding.
Patients and methods
A retrospective study was carried out from January 2010 to February 2020 at a tertiary care medical center in Tunisia. Clinical and endoscopic data were collected from each patient’s medical reports. We divided the patients into two groups: group A, patients with symptomatic GIAD; and group B, patients with incidental lesions. Group A was subsequently divided into two subgroups, according to the presence or absence of recurrent bleeding. The groups were compared by clinical, laboratory, and endoscopic features.
Results
GIAD was diagnosed in 114 patients, with a mean age of 70 ± 13.3 years. GIAD lesions were mainly located in the colon (n = 72, 63%). Fifty-four patients (47%) presented with GIAD-related bleeding. The bleeding diagnosis was made during endoscopic procedures by visualizing active bleeding and the stigmata of recent hemorrhage in 10 (18.5%) and 12 (22.2%) cases, respectively. Most of the patients were treated by argon plasma coagulation (93%). Predictive factors of bleeding were age > 75 years, number of lesions >10, chronic kidney disease, diabetes mellitus, and coronary artery disease (p: 0.008; 0.002; 0.016; 0.048; and 0.039, respectively).
Conclusion
Knowledge of the predictive factors of bleeding aids endoscopists in the decision-making process in cases of angiodysplasia.
{"title":"Clinical features and bleeding risk factors of angiodysplasia lesions in a Tunisian population","authors":"S. Nasr, A. Khsiba, L. Hamzaoui, M. Mahmoudi, A. Ben-Mohamed, M. Yaakoubi, M. Medhioub, M. Azzouz","doi":"10.1016/j.rgmxen.2023.03.002","DOIUrl":"10.1016/j.rgmxen.2023.03.002","url":null,"abstract":"<div><h3>Introduction</h3><p>Gastrointestinal angiodysplasia (GIAD) is the most common vascular anomaly in the gastrointestinal (GI) tract, yet little is known about the factors favoring their bleeding. Our study aim was to determine the characteristics of patients with GIAD lesions in a Tunisian population and identify the risk factors of bleeding.</p></div><div><h3>Patients and methods</h3><p>A retrospective study was carried out from January 2010 to February 2020 at a tertiary care medical center in Tunisia. Clinical and endoscopic data were collected from each patient’s medical reports. We divided the patients into two groups: group A, patients with symptomatic GIAD; and group B, patients with incidental lesions. Group A was subsequently divided into two subgroups, according to the presence or absence of recurrent bleeding. The groups were compared by clinical, laboratory, and endoscopic features.</p></div><div><h3>Results</h3><p>GIAD was diagnosed in 114 patients, with a mean age of 70 ± 13.3 years. GIAD lesions were mainly located in the colon (n = 72, 63%). Fifty-four patients (47%) presented with GIAD-related bleeding. The bleeding diagnosis was made during endoscopic procedures by visualizing active bleeding and the stigmata of recent hemorrhage in 10 (18.5%) and 12 (22.2%) cases, respectively. Most of the patients were treated by argon plasma coagulation (93%). Predictive factors of bleeding were age > 75 years, number of lesions >10, chronic kidney disease, diabetes mellitus, and coronary artery disease (<em>p</em>: 0.008; 0.002; 0.016; 0.048; and 0.039, respectively).</p></div><div><h3>Conclusion</h3><p>Knowledge of the predictive factors of bleeding aids endoscopists in the decision-making process in cases of angiodysplasia.</p></div>","PeriodicalId":74705,"journal":{"name":"Revista de gastroenterologia de Mexico (English)","volume":"89 1","pages":"Pages 31-41"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2255534X23000257/pdfft?md5=ea352d5ba5b16f81ba0fa4fb0370b169&pid=1-s2.0-S2255534X23000257-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9188436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-01DOI: 10.1016/j.rgmxen.2022.08.002
A.F. Romano-Munive , C. Moctezuma-Velázquez , J. Sauma-Rodríguez , P. Ramos-Martínez , A. Torre-Delgadillo
Introduction
Autoimmune hepatitis (AIH) is associated with periportal infiltration by plasma cells. Plasma cell detection is routinely performed through hematoxylin and eosin (H&E) staining. The present study aimed to assess the utility of CD138, an immunohistochemical plasma cell marker, in the evaluation of AIH.
Materials and methods
A retrospective study was conducted, in which cases consistent with AIH, within the time frame of 2001 and 2011, were collected. Routine H&E-stained sections were used for evaluation. CD138 immunohistochemistry (IHC) was performed to detect plasma cells.
Results
Sixty biopsies were included. In the H&E group, the median and interquartile range (IQR) was 6 (4-9) plasma cells/high power field (HPF) and was 10 (IQR 6-20) plasma cells/HPF in the CD138 group (p < 0.001). There was a significant correlation between the number of plasma cells determined by H&E and CD138 (p = 0.31, p = 0.01). No significant correlation was found between the number of plasma cells determined by CD138 and IgG level (p = 0.21, p = 0.09) or stage of fibrosis (p = 0.12, p = 0.35), or between IgG level and stage of fibrosis (p = 0.17, p = 0.17). No significant correlation was found between the treatment response and the number of plasma cells determined by H&E (p = 0.11, p = 0.38), CD138 (p = 0.07, p = 0.55), or stage of fibrosis (p = 0.16, p = 0.20). CD138 expression was different between the treatment response groups (p = 0.04).
Conclusion
CD138 increased the detection of plasma cells in liver biopsies of patients with AIH, when compared with routine H&E staining. However, there was no correlation between the number of plasma cells determined by CD138 and serum IgG levels, stage of fibrosis, or response to treatment.
{"title":"CD138 immunohistochemistry identifies more plasma cells compared with hematoxylin and eosin staining in autoimmune hepatitis. An observational study","authors":"A.F. Romano-Munive , C. Moctezuma-Velázquez , J. Sauma-Rodríguez , P. Ramos-Martínez , A. Torre-Delgadillo","doi":"10.1016/j.rgmxen.2022.08.002","DOIUrl":"10.1016/j.rgmxen.2022.08.002","url":null,"abstract":"<div><h3>Introduction</h3><p>Autoimmune hepatitis (AIH) is associated with periportal infiltration by plasma cells. Plasma cell detection is routinely performed through hematoxylin and eosin (H&E) staining. The present study aimed to assess the utility of CD138, an immunohistochemical plasma cell marker, in the evaluation of AIH.</p></div><div><h3>Materials and methods</h3><p>A retrospective study was conducted, in which cases consistent with AIH, within the time frame of 2001 and 2011, were collected. Routine H&E-stained sections were used for evaluation. CD138 immunohistochemistry (IHC) was performed to detect plasma cells.</p></div><div><h3>Results</h3><p>Sixty biopsies were included. In the H&E group, the median and interquartile range (IQR) was 6 (4-9) plasma cells/high power field (HPF) and was 10 (IQR 6-20) plasma cells/HPF in the CD138 group (p < 0.001). There was a significant correlation between the number of plasma cells determined by H&E and CD138 (p = 0.31, p = 0.01). No significant correlation was found between the number of plasma cells determined by CD138 and IgG level (p = 0.21, p = 0.09) or stage of fibrosis (p = 0.12, p = 0.35), or between IgG level and stage of fibrosis (p = 0.17, p = 0.17). No significant correlation was found between the treatment response and the number of plasma cells determined by H&E (p = 0.11, p = 0.38), CD138 (p = 0.07, p = 0.55), or stage of fibrosis (p = 0.16, p = 0.20). CD138 expression was different between the treatment response groups (p = 0.04).</p></div><div><h3>Conclusion</h3><p>CD138 increased the detection of plasma cells in liver biopsies of patients with AIH, when compared with routine H&E staining. However, there was no correlation between the number of plasma cells determined by CD138 and serum IgG levels, stage of fibrosis, or response to treatment.</p></div>","PeriodicalId":74705,"journal":{"name":"Revista de gastroenterologia de Mexico (English)","volume":"89 1","pages":"Pages 52-56"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2255534X23000270/pdfft?md5=148927a77132514dce6a9aad4fe4a080&pid=1-s2.0-S2255534X23000270-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9192639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-01DOI: 10.1016/j.rgmxen.2023.04.002
N.V. Alva , O.R. Méndez , J.C. Gasca , I. Salvador , N. Hernández , M. Valdez
Introduction and aim
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged, causing the current pandemic of acute respiratory disease known as COVID-19. Liver injury due to COVID-19 is defined as any liver injury occurring during the course of the disease and treatment of patients with COVID-19, with or without liver disease. The incidence of elevated liver transaminases, alanine aminotransferase (ALT) and aspartate aminotransferase (AST), ranges from 2.5 to 76.3%. The aim of the present study was to describe the hepatic biochemical abnormalities, after a SARS-CoV-2-positive polymerase chain reaction (PCR) test, and the mortality rate in critically ill patients.
Materials and methods
A retrospective study was conducted that included 70 patients seen at a private hospital in Mexico City, within the time frame of February-December 2021. Median patient age was 44.5 years (range: 37-57.2) and 43 (61.4%) of the patients were men. Liver function tests were performed on the patients at hospital admission.
Results
Gamma glutamyl transferase (GGT) levels were elevated (p = 0.032), as were those of AST (p = 0.011) and ALT (p = 0.021). The patients were stratified into age groups: 18-35, 36-50, and > 50 years of age. The 18 to 35-year-olds had the highest liver enzyme levels and transaminase levels were higher, the younger the patient. Due to the low mortality rate (one patient whose death did not coincide with a hepatic cause), the multivariate analysis showed an R2 association of 0.689, explained by AST, GGT, and C-reactive protein levels.
Conclusions
Despite the increase in transaminases in our study population during the course of COVID-19, there was no increase in mortality. Nevertheless, hospitalized patient progression should be continuously followed.
{"title":"Liver injury due to COVID-19 in critically ill adult patients. A retrospective study","authors":"N.V. Alva , O.R. Méndez , J.C. Gasca , I. Salvador , N. Hernández , M. Valdez","doi":"10.1016/j.rgmxen.2023.04.002","DOIUrl":"10.1016/j.rgmxen.2023.04.002","url":null,"abstract":"<div><h3>Introduction and aim</h3><p>Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged, causing the current pandemic of acute respiratory disease known as COVID-19. Liver injury due to COVID-19 is defined as any liver injury occurring during the course of the disease and treatment of patients with COVID-19, with or without liver disease. The incidence of elevated liver transaminases, alanine aminotransferase (ALT) and aspartate aminotransferase (AST), ranges from 2.5 to 76.3%. The aim of the present study was to describe the hepatic biochemical abnormalities, after a SARS-CoV-2-positive polymerase chain reaction (PCR) test, and the mortality rate in critically ill patients.</p></div><div><h3>Materials and methods</h3><p>A retrospective study was conducted that included 70 patients seen at a private hospital in Mexico City, within the time frame of February-December 2021. Median patient age was 44.5 years (range: 37-57.2) and 43 (61.4%) of the patients were men. Liver function tests were performed on the patients at hospital admission.</p></div><div><h3>Results</h3><p>Gamma glutamyl transferase (GGT) levels were elevated (p = 0.032), as were those of AST (p = 0.011) and ALT (p = 0.021). The patients were stratified into age groups: 18-35, 36-50, and > 50 years of age. The 18 to 35-year-olds had the highest liver enzyme levels and transaminase levels were higher, the younger the patient. Due to the low mortality rate (one patient whose death did not coincide with a hepatic cause), the multivariate analysis showed an R<sup>2</sup> association of 0.689, explained by AST, GGT, and C-reactive protein levels.</p></div><div><h3>Conclusions</h3><p>Despite the increase in transaminases in our study population during the course of COVID-19, there was no increase in mortality. Nevertheless, hospitalized patient progression should be continuously followed.</p></div>","PeriodicalId":74705,"journal":{"name":"Revista de gastroenterologia de Mexico (English)","volume":"89 1","pages":"Pages 57-63"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10110936/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9391338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-01DOI: 10.1016/j.rgmxen.2023.10.001
L.E. Salgado-Cruz , D. Tueme-de la Peña
{"title":"Response to Sisa et al. Comments on the article: “Indocyanine green fluorescence angiography in colorectal surgery: A retrospective case-control analysis in Mexico”","authors":"L.E. Salgado-Cruz , D. Tueme-de la Peña","doi":"10.1016/j.rgmxen.2023.10.001","DOIUrl":"10.1016/j.rgmxen.2023.10.001","url":null,"abstract":"","PeriodicalId":74705,"journal":{"name":"Revista de gastroenterologia de Mexico (English)","volume":"89 1","pages":"Page 171"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2255534X24000069/pdfft?md5=75c8f75851d850df75e100ab6b290a70&pid=1-s2.0-S2255534X24000069-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140133472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-01DOI: 10.1016/j.rgmxen.2023.02.005
M. Vilatobá
{"title":"Transjugular intrahepatic portosystemic shunt safety in patients on the liver transplantation waiting list. Risks and benefits","authors":"M. Vilatobá","doi":"10.1016/j.rgmxen.2023.02.005","DOIUrl":"10.1016/j.rgmxen.2023.02.005","url":null,"abstract":"","PeriodicalId":74705,"journal":{"name":"Revista de gastroenterologia de Mexico (English)","volume":"89 1","pages":"Pages 1-3"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2255534X23000397/pdfft?md5=87db60da14cf813ccd7c5fab2d25895c&pid=1-s2.0-S2255534X23000397-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9442951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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