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Totally implantable venous access devices: A restrospective analysis of morbidity and risk factors in a hospital with multi-technique approaches 全植入式静脉通路装置:对一家采用多种技术方法的医院的发病率和风险因素的回顾性分析
Q4 SURGERY Pub Date : 2024-02-09 DOI: 10.1016/j.sipas.2024.100237
Diogo Melo-Pinto , Tatiana Moreira-Marques , Emanuel Guerreiro , Marina Morais

Background

Totally implantable venous central access devices (TIVADs) can be implanted by open surgery or by direct puncture in the subclavian (ScV), internal jugular (IJV) or cephalic (CephV) veins.

Methods

A retrospective study was conducted in 201 patients. Thirty-day follow-up data was analyzed to compare the outcomes of different techniques and evaluation of risk factors.

Results

Complications were reported in 3.8 % of the patients with no overall differences between different vascular accesses. Direct puncture was associated with more accidental arterial punction (p = 0.01). History of previous catheters was a risk factor for immediate complications (p = 0.01) and patients with history of thoracic disease had more early and late complications (p = 0.03 and p = 0.04, respectively). Late complications were more common in patients over 60 years old (p = 0.04) and with chronic pain (p = 0.03).

Conclusion

There was no difference in overall complication rates between the implantation techniques. Further prospective randomized controlled trials would clarify the most effective technique.

背景可通过开放手术或直接穿刺锁骨下静脉(ScV)、颈内静脉(IJV)或头静脉(CephV)植入全植入式中央静脉通路装置(TIVAD)。结果3.8%的患者出现并发症,不同血管通路之间总体上没有差异。直接穿刺与更多的意外动脉穿刺有关(p = 0.01)。曾使用过导管是导致即刻并发症的一个风险因素(p = 0.01),而有胸腔疾病史的患者有更多的早期和晚期并发症(分别为 p = 0.03 和 p = 0.04)。结论两种植入技术的总体并发症发生率没有差异。进一步的前瞻性随机对照试验将明确最有效的技术。
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引用次数: 0
Donor hepatitis C status is not associated with an increased risk of acute rejection in kidney transplantation 供体丙型肝炎状态与肾移植急性排斥反应风险增加无关
Q4 SURGERY Pub Date : 2024-02-06 DOI: 10.1016/j.sipas.2024.100236
John C. Johnson , Trine Engebretsen , Muhammad Mujtaba , Heather L Stevenson , Rupak Kulkarni , A. Scott Lea , Akshata Moghe , Syed Hussain , Michael Kueht

Introduction

In renal transplantation, donor hepatitis C virus (HCV) status is crucial to consider when selecting a recipient given the high likelihood of transmission. We analyzed the effect of donor HCV status on post-renal transplant rejection and virologic infectious outcomes using electronic health record data from multiple US health care organizations.

Methods

Using real world data from electronic health records of renal transplant recipients, a propensity score-matched case-control study of one-year renal transplant outcomes was conducted on cohorts of HCV-negative recipients who received an organ from an HCV-positive donor (HCV D+/R-) versus from an HCV-negative donor (HCV D-/R-). Donor HCV positivity was defined as new recipient HCV positivity within 30 days post-transplant. Cohorts were matched by major risk factors for rejection including age, gender, race, etiologies of end-stage renal disease, dialysis dependence, donor type, induction immunosuppression, and virologic lab studies. The primary outcome was one-year incidence of rejection. Secondary outcomes included longitudinal measures of liver and kidney function, incidence of non-HCV viremia, and DAA treatment pathways and responses.

Results

Data from 900 renal transplant recipients were analyzed, 450 subjects per group (D+/R-, D-/R-). Mean age at transplant was 57.1 ± 11.9 years, 60 % were male, and 38 % were African American. Kaplan-Meier analysis showed a significantly increased incidence of one-year rejection for HCV D-/R- compared to HCV D+/R- (16.6% vs 22.8 %, p = 0.02). This difference did not persist on a sub-analysis excluding subjects with delayed graft function (DGF) (16.3% vs 19.2 %, p = 0.25). Although mean eGFR was initially higher in HCV D+/R-, there were no significant differences in liver or kidney allograft function at 12 months. There was no significant difference for composite viremia (CMV/EBV/BK; 37.66% vs 31.60 %, p = 0.07). The most common DAA regimen was glecaprevir/pibrentasvir (52.8 %). DAA treatment responses were excellent, with most subjects having a negative viral load by 90 days (mean: 1.7 ± 1.9 log units/mL).

Conclusion

Donor HCV positivity did not negatively impact one-year rejection outcomes post-renal transplantation. Importantly, this effect was not biased by age. Anti-HCV treatment was effective and liver and kidney function were excellent at one-year post-transplant. These data support the continued expansion of the donor pool by utilizing organs from HCV-positive donors in the era of anti-HCV direct-acting antiviral therapies.

导言:在肾移植手术中,由于丙型肝炎病毒 (HCV) 传播的可能性很高,因此在选择受体时必须考虑供体的丙型肝炎病毒 (HCV) 感染情况。我们利用美国多家医疗机构的电子健康记录数据分析了供体丙型肝炎病毒感染状况对肾移植术后排斥反应和病毒学感染结果的影响。方法利用肾移植受者电子健康记录中的真实数据,对接受来自 HCV 阳性供体(HCV D+/R-)和来自 HCV 阴性供体(HCV D-/R-)的器官的 HCV 阴性受者队列进行了倾向得分匹配病例对照研究,以了解一年的肾移植结果。供体 HCV 阳性定义为移植后 30 天内新的受体 HCV 阳性。根据排斥反应的主要风险因素(包括年龄、性别、种族、终末期肾病病因、透析依赖性、供体类型、诱导免疫抑制和病毒学实验室研究)对组群进行配对。主要结果是一年的排斥反应发生率。次要结果包括肝肾功能的纵向测量、非HCV病毒血症的发生率以及DAA治疗途径和反应。结果分析了900名肾移植受者的数据,每组450人(D+/R-、D-/R-)。移植时的平均年龄为 57.1 ± 11.9 岁,60% 为男性,38% 为非裔美国人。Kaplan-Meier 分析显示,与 HCV D+/R- 相比,HCV D-/R- 一年期排斥反应发生率明显增加(16.6% vs 22.8%,p = 0.02)。在排除移植物功能延迟(DGF)受试者(16.3% vs 19.2%,p = 0.25)的子分析中,这一差异并没有持续存在。虽然 HCV D+/R- 患者的平均 eGFR 最初较高,但 12 个月后肝脏或肾脏的异体移植功能没有显著差异。复合病毒血症(CMV/EBV/BK;37.66% vs 31.60%,p = 0.07)无明显差异。最常见的 DAA 方案是 glecaprevir/pibrentasvir(52.8%)。DAA治疗反应良好,大多数受试者的病毒载量在90天后呈阴性(平均:1.7 ± 1.9 log units/mL)。重要的是,这种影响不受年龄的影响。抗HCV治疗有效,移植后一年肝肾功能良好。这些数据支持在抗HCV直接作用抗病毒疗法时代利用HCV阳性供体的器官继续扩大供体库。
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引用次数: 0
Variation in approach for midsize (4-6cm) ventral hernias across a statewide quality improvement collaborative 全州质量改进合作组织在治疗中等大小(4-6 厘米)腹股沟疝气方法上的差异
Q4 SURGERY Pub Date : 2024-01-23 DOI: 10.1016/j.sipas.2024.100235
Anne P. Ehlers , Alex K. Hallway , Sean M. O'Neill , Brian T. Fry , Ryan A. Howard , Jenny M. Shao , Michael J. Englesbe , Justin B Dimick , Dana A Telem , Grace J Kim

Introduction

Repair of midsize (4–6 cm) ventral hernias is challenging given lack of guidelines. Within this context, we sought to characterize surgical approach among patients undergoing repair of midsize ventral hernias within the only population-level, clinically-nuanced hernia registry in the US.

Methods

Retrospective cohort study of patients undergoing ventral hernia repair in the Michigan Surgical Quality Collaborative Core Optimization Hernia Registry (MSQCCOHR). MSQCCOHR is the only US population-level registry that captures clinically-nuanced data pertaining to patient hernia characteristics. We included patients who underwent repair of a 4–6 cm hernia from January 1, 2020-June 30, 2022. We stratified repair type as open or minimally invasive and used a multivariable logistic regression model to identify factors associated with MIS approach. Secondary outcomes included complications rate.

Results

Among 771 patients, mean hernia width (SD) was 4.7 cm (0.8) and 339 (44 %) underwent MIS approach. Patients with MIS approach had lower BMI (33.5 vs 34.8, p = 0.02) and less often were ASA class III (47.5% vs 54.6 %, p = 0.02) or ASA class IV (2.4% vs 4.2 %, p = 0.02). MIS approach was associated with smaller mean hernia width (4.71 cm vs 4.84 cm, p = 0.02) and was used more often in the elective setting (94.4% vs 84.0 %, p < 0.01). In the multivariable logistic regression model, higher BMI (aOR 0.97, 95 % CI 0.94–0.99) and urgent/emergent surgery (aOR 0.43, 95 % CI 0.24–0.79) were associated with lower odds of MIS. We found no significant association between MIS and risk of complications (aOR 0.62, 95 % CI 0.37–1.04). Among patients undergoing MIS, more than half (n = 236, 69.6 %) had a robotic approach but there were few patient factors associated with this.

Conclusion

Among patients with midsize hernias, few patient-level factors are associated with approach. This may indicate that surgeon preference factors largely into this decision.

导言:由于缺乏相关指南,中型(4-6 厘米)腹股沟疝的修补具有挑战性。在这种情况下,我们试图在美国唯一的人口级临床平衡疝气登记处对接受中型腹股沟疝修补术的患者的手术方法进行特征分析。方法对密歇根州外科质量协作核心优化疝气登记处(MSQCCOHR)中接受腹股沟疝修补术的患者进行回顾性队列研究。MSQCCOHR 是美国唯一的人口级注册机构,可获取与患者疝气特征相关的临床平衡数据。我们纳入了 2020 年 1 月 1 日至 2022 年 6 月 30 日期间接受 4-6 厘米疝修补术的患者。我们将修复类型分为开放式和微创式,并使用多变量逻辑回归模型确定与微创式方法相关的因素。结果771名患者中,疝的平均宽度(标清)为4.7厘米(0.8),339人(44%)接受了MIS方法。采用 MIS 方法的患者体重指数较低(33.5 vs 34.8,P = 0.02),ASA III 级(47.5% vs 54.6%,P = 0.02)或 ASA IV 级(2.4% vs 4.2%,P = 0.02)的患者较少。MIS 方法与疝的平均宽度较小(4.71 厘米 vs 4.84 厘米,p = 0.02)有关,且更多用于择期手术(94.4% vs 84.0%,p <0.01)。在多变量逻辑回归模型中,较高的体重指数(aOR 0.97,95 % CI 0.94-0.99)和紧急/急诊手术(aOR 0.43,95 % CI 0.24-0.79)与较低的 MIS 几率相关。我们发现 MIS 与并发症风险(aOR 0.62,95 % CI 0.37-1.04)之间无明显关联。在接受 MIS 的患者中,半数以上(n = 236,69.6%)采用了机器人手术方法,但与此相关的患者因素很少。结论在中型疝气患者中,患者层面的因素很少与手术方式相关,这可能表明外科医生的偏好在很大程度上影响了患者的决定。
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引用次数: 0
Delayed return of bowel function after general surgery in South Australia 南澳大利亚州普外科手术后肠道功能延迟恢复情况
Q4 SURGERY Pub Date : 2024-01-10 DOI: 10.1016/j.sipas.2024.100234
Joshua G. Kovoor , Stephen Bacchi , Brandon Stretton , Aashray K. Gupta , Jonathan Henry W. Jacobsen , Minh-Son To , Rudy Goh , Joseph N. Hewitt , Christopher D. Ovenden , Leigh Warren , Matthew Marshall-Webb , Karen L. Jones , Benjamin A. Reddi , Danny Liew , Christopher Dobbins , Robert T. Padbury , Peter J. Hewett , Thomas J. Hugh , Markus I. Trochsler , Guy J. Maddern

Introduction

Reference ranges for determining pathological versus normal postoperative return of bowel function are not well characterised for general surgery patients. This study aimed to characterise time to first postoperative passage of stool after general surgery; determine associations between clinical factors and delayed time to first postoperative stool; and evaluate the association between delay to first postoperative stool and prolonged length of hospital stay.

Methods

This study included consecutive admissions at two tertiary hospitals across a two-year period whom underwent a range of general surgery operations. Multivariable logistic regression analyses were conducted to determine associations between the explanatory variables and delayed first postoperative stool, and between delayed first postoperative stool and length of hospital stay. The previously specified explanatory variables were used, with the addition of the dichotomised ≥4-day delay to first postoperative stool. Prolonged length of hospital stay was considered ≥7 days.

Results

2,212 general surgery patients were included. Median time to first postoperative stool was 2.28 (IQR 1.06–3.96). Median length of stay was 7.19 (IQR 4.50–12.01). Several operative characteristics and medication exposures were associated with delayed first postoperative stool. There was a statistically significant association between delayed first postoperative stool (≥4 days) and prolonged length of stay (≥7 days) (OR 4.34, 95 %CI 3.27 to 5.77, p < 0.001).

Conclusions

This study characterised expected reference ranges for time to return of bowel function across various general surgery operations and determined associations with clinical factors that may improve efficiency and identification of pathology within the postoperative course.

导言:普外科患者术后肠道功能恢复的病理与正常的参考范围尚未明确。本研究旨在描述普外科术后首次排便时间的特征;确定临床因素与术后首次排便时间延迟之间的关联;评估术后首次排便时间延迟与住院时间延长之间的关联。方法本研究纳入了两家三甲医院在两年内连续收治的接受一系列普外科手术的患者。通过多变量逻辑回归分析确定解释变量与术后首次排便延迟之间的关系,以及术后首次排便延迟与住院时间之间的关系。在使用之前指定的解释变量的基础上,增加了术后首次大便延迟≥4 天的二分变量。住院时间延长被视为≥7天。术后首次排便的中位时间为 2.28(IQR 1.06-3.96)。住院时间中位数为 7.19(IQR 4.50-12.01)。一些手术特征和药物暴露与术后首次排便延迟有关。该研究确定了各种普外科手术肠道功能恢复时间的预期参考范围,并确定了与临床因素的关联,这些临床因素可提高效率并在术后病理过程中进行识别。
{"title":"Delayed return of bowel function after general surgery in South Australia","authors":"Joshua G. Kovoor ,&nbsp;Stephen Bacchi ,&nbsp;Brandon Stretton ,&nbsp;Aashray K. Gupta ,&nbsp;Jonathan Henry W. Jacobsen ,&nbsp;Minh-Son To ,&nbsp;Rudy Goh ,&nbsp;Joseph N. Hewitt ,&nbsp;Christopher D. Ovenden ,&nbsp;Leigh Warren ,&nbsp;Matthew Marshall-Webb ,&nbsp;Karen L. Jones ,&nbsp;Benjamin A. Reddi ,&nbsp;Danny Liew ,&nbsp;Christopher Dobbins ,&nbsp;Robert T. Padbury ,&nbsp;Peter J. Hewett ,&nbsp;Thomas J. Hugh ,&nbsp;Markus I. Trochsler ,&nbsp;Guy J. Maddern","doi":"10.1016/j.sipas.2024.100234","DOIUrl":"https://doi.org/10.1016/j.sipas.2024.100234","url":null,"abstract":"<div><h3>Introduction</h3><p>Reference ranges for determining pathological versus normal postoperative return of bowel function are not well characterised for general surgery patients. This study aimed to characterise time to first postoperative passage of stool after general surgery; determine associations between clinical factors and delayed time to first postoperative stool; and evaluate the association between delay to first postoperative stool and prolonged length of hospital stay.</p></div><div><h3>Methods</h3><p>This study included consecutive admissions at two tertiary hospitals across a two-year period whom underwent a range of general surgery operations. Multivariable logistic regression analyses were conducted to determine associations between the explanatory variables and delayed first postoperative stool, and between delayed first postoperative stool and length of hospital stay. The previously specified explanatory variables were used, with the addition of the dichotomised ≥4-day delay to first postoperative stool. Prolonged length of hospital stay was considered ≥7 days.</p></div><div><h3>Results</h3><p>2,212 general surgery patients were included. Median time to first postoperative stool was 2.28 (IQR 1.06–3.96). Median length of stay was 7.19 (IQR 4.50–12.01). Several operative characteristics and medication exposures were associated with delayed first postoperative stool. There was a statistically significant association between delayed first postoperative stool (≥4 days) and prolonged length of stay (≥7 days) (OR 4.34, 95 %CI 3.27 to 5.77, <em>p</em> &lt; 0.001).</p></div><div><h3>Conclusions</h3><p>This study characterised expected reference ranges for time to return of bowel function across various general surgery operations and determined associations with clinical factors that may improve efficiency and identification of pathology within the postoperative course.</p></div>","PeriodicalId":74890,"journal":{"name":"Surgery in practice and science","volume":"16 ","pages":"Article 100234"},"PeriodicalIF":0.0,"publicationDate":"2024-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666262024000019/pdfft?md5=cdaebfe647c445c684835b5ed7869716&pid=1-s2.0-S2666262024000019-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139434624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A retrospective cohort study of the effect of sugammadex versus neostigmine on postoperative gastrointestinal motility in open colorectal surgical procedures 苏甘比与新斯的明对开放式结直肠手术术后胃肠道运动影响的回顾性队列研究
Q4 SURGERY Pub Date : 2023-12-24 DOI: 10.1016/j.sipas.2023.100233
Taylor N. Harris , Eric G. Johnson , Aric Schadler , Jitesh Patel , Ekaterina Fain , Laura M. Ebbitt

Introduction

Neuromuscular blockers (NMB) are used in surgical procedures to facilitate muscle relaxation and intubation. NMBs are then reversed at the end of the surgery with either an acetylcholinesterase inhibitor, such as neostigmine, or a modified cyclodextrin compound, such as sugammadex. Neostigmine and glycopyrrolate elicit counteracting cholinergic effects, potentially impairing postoperative gastrointestinal motility. This may have higher significance in colorectal surgery procedures given the baseline risk of delayed postoperative motility associated with some operations.

Methods

This is a retrospective, single-center, cohort review of open colorectal procedures that received either sugammadex alone, or neostigmine with glycopyrrolate. The primary outcome was time from end of colorectal procedure to time of first bowel movement. Secondary outcomes included incidence of postoperatively placed nasogastric tubes, nausea and vomiting, need for motility agents or TPN, hospital length of stay, 30-day hospital readmission or return to emergency department (ED).

Results

A total of 99 patients were included in the sugammadex group and 350 in the neostigmine + glycopyrrolate group. Time to first bowel movement was significantly faster in the sugammadex group (61.7 h) compared to the neostigmine group (71.9 h) (p = 0.03). Secondary outcomes were similar between the two groups, except for a higher incidence of postoperative nausea and vomiting in the sugammadex group (p = 0.04).

Discussion

These findings support that sugammadex may be utilized for open colorectal procedures to aid in earlier discharge which could lead to differences in length of stay. Using sugammadex did not result in patients requiring additional interventions or experiencing symptoms of post-operative ileus.

Conclusion

Compared to neostigmine and glycopyrrolate, patients receiving sugammadex for neuromuscular blockade reversal in open colorectal procedures experienced a shorter time to return of bowel function. The results from this study confirm the findings from previous retrospective studies that were conducted.

导言神经肌肉阻滞剂(NMB)用于外科手术,以促进肌肉松弛和插管。在手术结束时,NMB 会被乙酰胆碱酯酶抑制剂(如新斯的明)或改良环糊精化合物(如舒甘马定)逆转。新斯的明和甘草酸苷会产生对抗胆碱能的作用,可能会影响术后胃肠道的蠕动。这是一项回顾性、单中心、队列回顾性研究,研究对象是接受单独使用苏加麦司或新斯的明加甘草酸盐治疗的开放性结直肠手术。主要结果是从结肠直肠手术结束到首次排便的时间。次要结果包括术后放置鼻胃管的发生率、恶心和呕吐、对肠蠕动剂或 TPN 的需求、住院时间、30 天内再次入院或返回急诊科(ED)。与新斯的明组(71.9 小时)相比,苏加麦胺组首次排便时间(61.7 小时)明显更快(p = 0.03)。除了术后恶心和呕吐的发生率在苏甘麦克斯组较高外(p = 0.04),两组的次要结果相似。讨论这些研究结果支持苏甘麦克斯可用于开放式结直肠手术,以帮助患者提前出院,从而缩短住院时间。结论与新斯的明和甘草酸苷相比,在开放式结直肠手术中接受苏甘麦克斯逆转神经肌肉阻滞的患者恢复肠道功能的时间更短。这项研究的结果证实了之前进行的回顾性研究的结果。
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引用次数: 0
Utility of beta-lactam allergy assessment in patients receiving vancomycin for surgical prophylaxis 对接受万古霉素手术预防的患者进行β-内酰胺过敏评估的实用性
Q4 SURGERY Pub Date : 2023-12-21 DOI: 10.1016/j.sipas.2023.100232
Kendall J. Tucker , YoungYoon Ham , Haley K. Holmer , Caitlin M. McCracken , Ellie Sukerman , James S. Lewis II , Jessina C. McGregor

Background

Beta-lactam antibiotics are first-line agents for most patients receiving antimicrobial prophylaxis in surgical procedures. Despite evidence showing low cross-reactivity between penicillins and cephalosporins, patients with beta-lactam allergies commonly receive vancomycin as an alternative to avoid allergic reaction.

Methods

Adult patients receiving vancomycin for surgical prophylaxis with a reported beta-lactam allergy at our institution between August 2017 to July 2018 were retrospectively evaluated for potential eligibility for penicillin allergy testing and/or receipt of standard prophylaxis.

Results

Among 830 patients who received vancomycin for surgical prophylaxis, 196 reported beta-lactam allergy and were included in the analysis. Approximately 40 % of surgeries were orthopedic. Of patients receiving vancomycin as first-line therapy, 189 (96.4 %) were potentially eligible for beta-lactam prophylaxis.

Conclusions

Patients with beta-lactam allergies often qualify for receipt of a first-line antibiotic. An opportunity exists for improved allergy assessment as an antimicrobial stewardship intervention in surgical prophylaxis.

背景β-内酰胺类抗生素是大多数接受外科手术抗菌预防的患者的一线用药。尽管有证据显示青霉素类和头孢菌素类之间的交叉反应较低,但对β-内酰胺过敏的患者通常会选择万古霉素来避免过敏反应。方法回顾性评估我院2017年8月至2018年7月期间接受万古霉素手术预防且报告对β-内酰胺过敏的成人患者,以确定其是否有资格接受青霉素过敏检测和/或接受标准预防。约 40% 的手术为骨科手术。在接受万古霉素一线治疗的患者中,有 189 人(96.4%)可能符合接受β-内酰胺预防治疗的条件。有机会改进过敏评估,将其作为手术预防中的抗菌药物管理干预措施。
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引用次数: 0
Impact of fecal diversion in Perineal Necrotizing Soft Tissue Infection on disease survival: A large retrospective study 会阴坏死性软组织感染患者粪便转流对存活率的影响: 一项大型回顾性研究
Q4 SURGERY Pub Date : 2023-12-16 DOI: 10.1016/j.sipas.2023.100231
Vincent MAYORAL , Dorothée COQUEREL-BEGHIN , Jean-Nicolas CORNU , Valérie BRIDOUX , Isabelle AUQUIT-AUCKBUR , Christian PFISTER

Introduction

Colostomy is usually proposed during the acute phase of Fournier Gangrene, nevertheless its impact on disease outcome remains still debated. We conducted a retrospective study in an academic center to determine the impact of fecal diversion on disease morbidity and specific survival.

Methods

All medical charts of Fournier Gangrene cases in the past 30-years were reviewed. Mortality rate, hospitalization duration, time to complete healing and number of excision surgeries were compared between the stoma and the non-stoma groups. Time between initial diagnosis and stoma creation, type of fecal diversion, as well as specific morbidity were analyzed.

Results

Of 89 patients included, 59 had stoma creation. Stoma group had significant higher catecholamine drugs use. Mortality, time to complete healing and number of excision surgeries did not significantly differ between both groups. Hospitalization duration was significantly higher in the stoma group. Mortality and hospitalization duration were higher when loop transverse colostomy was performed, and when colostomy was done in the first 3-days. Morbidity occurred in 41 % of patients with colostomy, with 25 % life-threatening complications. 31 % of colostomies remained definitive, while median time to intestinal recovery was 159-days.

Discussion

Consistently with current literature, disease survival was not improved by colostomy creation although skewed. Colostomy creation was associated with a higher hospitalization duration and a significant morbidity including risk of definitive stoma. To limit over-indicated stoma and improve early results, a damage control strategy using colostomy creation is advised.

Conclusion

The benefit of colostomy during the acute phase of Fournier Gangrene was uncertain, with no clear impact on mortality. In fact, colostomy was associated with increased hospitalization duration and specific morbidity. Finally, when fecal diversion is deemed necessary, we advocate for coelioscopic delayed loop left colostomy. Alternative minimally invasive treatment as bowel catheters should also be discussed.

导言通常在福尼尔坏疽急性期建议进行造口术,但其对疾病预后的影响仍存在争议。我们在一家学术中心进行了一项回顾性研究,以确定粪便转流对疾病发病率和具体存活率的影响。比较造口组和非造口组的死亡率、住院时间、完全愈合时间和切除手术次数。结果 89 名患者中,59 人造口术。造口组使用儿茶酚胺药物的比例明显较高。两组患者的死亡率、完全愈合时间和切除手术次数无明显差异。造口组的住院时间明显较长。进行环形横结肠造口术和在头三天进行结肠造口术时,死亡率和住院时间较长。41%的结肠造口患者出现了发病率,其中25%出现了危及生命的并发症。31%的结肠造口术仍然有效,而肠道恢复的中位时间为 159 天。建立结肠造口与较长的住院时间和显著的发病率相关,包括最终造口的风险。结论 在福尼尔坏疽急性期进行结肠造口术的益处并不确定,对死亡率也没有明显影响。事实上,结肠造口术与住院时间延长和特定发病率增加有关。最后,当认为有必要进行粪便转流时,我们主张采用腹腔镜延迟环状左结肠造口术。此外,还应讨论肠导管等其他微创治疗方法。
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引用次数: 0
The effect of exercise in patients with colorectal cancer surgery: A systematic review 运动对结直肠癌手术患者的影响:系统回顾
Q4 SURGERY Pub Date : 2023-12-01 DOI: 10.1016/j.sipas.2023.100227
Ece Ekici , Mehmet Özkeskin , Fatih Özden

Background

Current reviews have primarily focused on the effect of exercise on colorectal cancer patient's functional abilities and cardiorespiratory performance. There is a need for more comprehensive studies to determine the effects of exercise on different components. We aimed to investigate recent pre-operative and post-operative exercise interventions conducted in patients undergoing or scheduled for colorectal cancer surgery.

Methods

The PRISMA guidelines were followed. PubMed, Web-of-Science (WoS) and Scopus databases were searched. The Physiotherapy Evidence Database (PEDro) tool provided the methodological quality and risk of bias for the included trials. The review findings are presented using the principles of narrative synthesis. The synthesis process encompasses steps such as “developing a preliminary synthesis, exploring relationships within and between studies, and assessing the robustness of the synthesis.”

Results

The combined use of aerobic and resistance exercises reduces hospital stay in the preoperative period, long-term exercise interventions significantly improve functional parameters, and progressive relaxation exercises performed during the preoperative and postoperative periods reduce anxiety.

Conclusions

Long-term and combined (relaxation, aerobic and resistance) rehabilitation in colorectal cancer surgery is essential to improve the physical and psychological parameters of patients. Further studies should focus on more comprehensive, long-term exercise programs and separately investigate the effects of each exercise type.

背景目前的综述主要关注运动对结直肠癌患者功能能力和心肺功能的影响。我们需要更全面的研究来确定运动对不同方面的影响。我们旨在调查近期对正在接受或计划接受结直肠癌手术的患者进行的术前和术后运动干预。检索了 PubMed、Web-of-Science (WoS) 和 Scopus 数据库。物理治疗证据数据库(PEDro)工具提供了纳入试验的方法学质量和偏倚风险。综述结果采用叙事综合的原则进行表述。综述过程包括 "进行初步综述、探索研究内部和研究之间的关系、评估综述的稳健性 "等步骤。结果联合使用有氧运动和阻力运动可缩短术前住院时间,长期运动干预可显著改善功能参数,术前和术后进行的渐进式放松运动可减轻焦虑。结论结直肠癌手术中长期和联合(放松、有氧和阻力)康复治疗对改善患者的生理和心理参数至关重要。进一步的研究应侧重于更全面的长期锻炼计划,并分别调查每种锻炼方式的效果。
{"title":"The effect of exercise in patients with colorectal cancer surgery: A systematic review","authors":"Ece Ekici ,&nbsp;Mehmet Özkeskin ,&nbsp;Fatih Özden","doi":"10.1016/j.sipas.2023.100227","DOIUrl":"https://doi.org/10.1016/j.sipas.2023.100227","url":null,"abstract":"<div><h3>Background</h3><p>Current reviews have primarily focused on the effect of exercise on colorectal cancer patient's functional abilities and cardiorespiratory performance. There is a need for more comprehensive studies to determine the effects of exercise on different components. We aimed to investigate recent pre-operative and post-operative exercise interventions conducted in patients undergoing or scheduled for colorectal cancer surgery.</p></div><div><h3>Methods</h3><p>The PRISMA guidelines were followed. PubMed, Web-of-Science (WoS) and Scopus databases were searched. The Physiotherapy Evidence Database (PEDro) tool provided the methodological quality and risk of bias for the included trials. The review findings are presented using the principles of narrative synthesis. The synthesis process encompasses steps such as “developing a preliminary synthesis, exploring relationships within and between studies, and assessing the robustness of the synthesis.”</p></div><div><h3>Results</h3><p>The combined use of aerobic and resistance exercises reduces hospital stay in the preoperative period, long-term exercise interventions significantly improve functional parameters, and progressive relaxation exercises performed during the preoperative and postoperative periods reduce anxiety.</p></div><div><h3>Conclusions</h3><p>Long-term and combined (relaxation, aerobic and resistance) rehabilitation in colorectal cancer surgery is essential to improve the physical and psychological parameters of patients. Further studies should focus on more comprehensive, long-term exercise programs and separately investigate the effects of each exercise type.</p></div>","PeriodicalId":74890,"journal":{"name":"Surgery in practice and science","volume":"15 ","pages":"Article 100227"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666262023000736/pdfft?md5=b6c793e71cc82fee9d0192fcb82c3b59&pid=1-s2.0-S2666262023000736-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138490910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association between direct oral anticoagulant concentrations and clinical outcomes: A systematic review and meta-analysis 直接口服抗凝剂浓度与临床结果之间的关系:系统回顾与荟萃分析
Q4 SURGERY Pub Date : 2023-12-01 DOI: 10.1016/j.sipas.2023.100230
Brandon Stretton , Philip Harford , Joshua Kovoor , Stephen Bacchi , Aashray Gupta , Jaspreet Sandhu , Hollie Moran , Suzanne Edwards , Jonathon Henry W. Jacobsen , Guy Maddern , Mark Boyd

Introduction

Current guidelines suggest preoperative direct oral anticoagulant levels of < 30–50 ng/ml. However, there is limited evidence to guide this expert consensus. Reviewing assay titres and clinical outcomes may be able to inform perioperative care of the anticoagulated patient. This review aimed to determine whether DOAC assay plasma concentrations are associated with bleeding or systemic embolic events to better appreciate a possible therapeutic or hazardous reference range.

Methods

Systematic search, performed by an information specialist using a peer-reviewed search. Main search concepts were direct oral anticoagulant therapy for atrial fibrillation or venous thromboembolism. Data synthesised in narrative and tabular format whilst data that could be pooled was subjected to meta-analysis, using a random effects model. Meta regression was conducted for DOAC peak levels and clinical events. PRISMA guidelines were adhered to.

Results

Of 6717 retrieved publications, a total of 17 studies were included in the systematic review and 14 in the meta-analysis/regression. Studies report clinical outcome follow up ranging from 28 to 128 weeks. For every 10 ng/ml increase in DOAC assay trough and peak levels, the mean number of bleeding cases increases by 0.03(95 %CI: –0.32 –0.38, P = 0.84) and 0.09(95 %CI: –3.4 –5.3, P = 0.55) respectively, the mean number of major bleed cases increases by 0.01(95 %CI: –0.05 –0.07, P = 0.62) and 0.011(95 %CI: –0.32 –0.34, P = 0.74) respectively and the mean number of systemic embolic event cases decreases by 0.00039(95 %CI: –0.06 –0.0054, P = 0.88) and 0.04(95 %CI: –0.56 –0.48, P = 0.77) respectively.

Conclusion

There exists no significant, independent relationship, as determined by a univariate meta regression, between DOAC assay concentrations and a patient's risk of bleeding or systemic embolic embolism. This review also highlights the possibility of an absolute, patient specific DOAC assay concentration that may indicate adequate anticoagulation, above which further increases do not confer an increased risk of bleeding. However, further research to characterise this and its utility in the perioperative setting is required.

导言目前的指南建议术前直接口服抗凝剂水平为 30-50 纳克/毫升。然而,指导这一专家共识的证据有限。对检测滴度和临床结果进行回顾可为抗凝患者的围手术期护理提供参考。本综述旨在确定 DOAC 检测血浆浓度是否与出血或全身性栓塞事件有关,以便更好地了解可能的治疗或危险参考范围。主要检索概念为心房颤动或静脉血栓栓塞的直接口服抗凝疗法。数据以叙述和表格的形式进行综合,而可以汇总的数据则采用随机效应模型进行荟萃分析。对 DOAC 峰值水平和临床事件进行了元回归。结果 在检索到的 6717 篇文献中,共有 17 项研究被纳入系统综述,14 项研究被纳入元分析/回归。研究报告的临床结果随访时间从 28 周到 128 周不等。DOAC 检测谷值和峰值水平每增加 10 ng/ml,出血病例的平均数量分别增加 0.03(95 %CI:-0.32 -0.38,P = 0.84)和 0.09(95 %CI:-3.4 -5.3,P = 0.55),大出血病例的平均数量分别增加 0.01(95 %CI:-0.05 -0.07,P = 0.62)和 0.011(95 %CI:-0.32 -0.34,P = 0.结论通过单变量元回归确定,DOAC 检测浓度与患者出血或全身性栓塞风险之间不存在显著的独立关系。本综述还强调了一种可能性,即患者特定的 DOAC 检测浓度可能表明抗凝充分,超过这一浓度不会增加出血风险。不过,还需要进一步研究以确定其特征及其在围手术期环境中的用途。
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引用次数: 0
Recent trends in hand surgery fellowship applicants and programs 手外科研究金申请者和项目的最新趋势
Q4 SURGERY Pub Date : 2023-12-01 DOI: 10.1016/j.sipas.2023.100228
Christopher P. Bellaire , Emily M. Graham , Lauren M. Bracey , Harrison R. Ferlauto , Caleigh Weliver , Shaun D. Mendenhall , Eitan Melamed

Background

Hand surgery is a competitive fellowship that draws applicants from orthopedic, plastic, and general surgery. In 2010, recommendations from the American Academy of Orthopaedic Surgeons (AAOS) Board of Specialty Societies Match Oversight Committee and the American Society of Plastic Surgeons (ASPS) Plastic Surgery Workforce Task Force led to significant reforms to their respective workforces and training. This study characterizes trends in hand fellowship applicants and programs since these recommendations (2010–2023).

Materials and methods

We queried hand fellowship applicant and program data from the American Society for Surgery of the Hand (ASSH), the National Resident Matching Program (NRMP), and the Accreditation Council for Graduate Medical Education (ACGME).

Results, discussion and conclusions

From 2010 to 2023, the number of ACGME-accredited hand fellowship programs increased across specialties (orthopedic surgery, 58 to 74 (27.6 % increase, R = 0.97, p < 0.001); plastic surgery, 14 to 19 (35.7 % increase, R = 0.91, p < 0.001); general surgery, 1 to 2 (50 % increase, R = 0.71, p = 0.004). The number of available fellowship positions commensurately increased by 38.8 % over the same time period. The number of applicants did not significantly change between 2010 (155 applicants) and 2023 (198 applicants) (R = 0.32, p = 0.27). The ratio of applicants-to-positions significantly decreased from 2010 (1.12 applicants per position) to 2023 (1.04 applicants per position) (R = -0.74, p = 0.003). Yet, applicants ranked nearly twice as many programs in 2023 (14.9 programs per applicant) compared to in 2010 (7.5 programs per applicant) (R = 0.98, p < 0.001). In light of the American Orthopaedic Association endorsing signal preferencing in the 2022–2023 residency Match, strategies to optimize rank lists in the fellowship application process should be further explored.

背景手外科是一项竞争激烈的研究金,吸引了来自骨科、整形外科和普通外科的申请人。2010 年,美国矫形外科医师学会(AAOS)专科学会委员会匹配监督委员会和美国整形外科医师学会(ASPS)整形外科劳动力工作组提出建议,对各自的劳动力和培训进行了重大改革。材料与方法我们查询了美国手外科学会(ASSH)、国家住院医师匹配计划(NRMP)和毕业后医学教育认证委员会(ACGME)的手部研究金申请人和项目数据。结果、讨论和结论从2010年到2023年,ACGME认可的手部研究金项目数量在各专科中都有所增加(整形外科从58个增加到74个(增加27.6%,R = 0.97,p = 0.001);整形外科从14个增加到19个(增加35.7%,R = 0.91,p = 0.001);普通外科从1个增加到2个(增加50%,R = 0.71,p = 0.004)。同期,可提供的研究金职位数量相应增加了 38.8%。申请人数在 2010 年(155 人)和 2023 年(198 人)之间没有明显变化(R = 0.32,p = 0.27)。从 2010 年(每个职位有 1.12 名申请人)到 2023 年(每个职位有 1.04 名申请人),申请人与职位的比率明显下降(R = -0.74,p = 0.003)。然而,与 2010 年(每名申请人 7.5 个专业)相比,2023 年的申请人排名(每名申请人 14.9 个专业)几乎是 2010 年的两倍(R = 0.98,p = 0.001)。鉴于美国骨科协会赞同在2022-2023年住院医师Match中进行信号优选,因此应进一步探索在奖学金申请过程中优化排名表的策略。
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引用次数: 0
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Surgery in practice and science
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