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Evidence-based management of the patient with synchronous colorectal cancer and liver metastases 对同步性结直肠癌肝转移患者的循证管理
IF 1.4 Q3 SURGERY Pub Date : 2024-08-01 DOI: 10.1016/j.sopen.2024.07.006
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引用次数: 0
Where are they now? An analysis of integrated cardiothoracic surgery residency applicants 他们现在在哪里?心胸外科住院医师综合申请者分析
IF 1.4 Q3 SURGERY Pub Date : 2024-08-01 DOI: 10.1016/j.sopen.2024.07.011

Changes in cardiothoracic surgery (CTS) workforce trends have affected training paradigms to include the establishment of integrated six-year CTS residency (I6) programs. This study aimed to determine commitment of selected I6 program applicants to the specialty.

Internal archives at a single institution were accessed to identify applicants interviewed for an I6 position from 2014 to 2016. A systematic internet search of publicly available information was performed to identify the trainee's current specialty. Descriptive analysis was performed.

Forty-seven applicants were identified. Successful search results were achieved for 97.9 % of the applicants. One applicant was excluded, resulting in a cohort of 45. 48.9 % of the applicants successfully matched into I6 programs. Of the 23 who did not match into an I6 program, 91.3 % began a General Surgery (GS) residency. When looking solely at the GS trainees, 71.4 % sought and matched into a traditional or 4/3 CTS residency. In total, 77.8 % of the cohort are currently pursuing careers in cardiothoracic surgery.

The study identified a strong continued interest in the field of CT Surgery among those interviewed for integrated residency. The methodology used in this study provided an effective way to follow career choice of applicants interviewed and could be applied by additional programs to further elucidate career choice and levels of commitment.

心胸外科(CTS)劳动力趋势的变化影响了培训模式,包括建立六年制心胸外科综合住院医师培训项目(I6)。本研究旨在确定选定的I6项目申请者对该专业的承诺。研究人员查阅了一家机构的内部档案,以确定2014年至2016年接受I6职位面试的申请者。对公开信息进行了系统的互联网搜索,以确定受训者目前的专业。对结果进行了描述性分析。97.9%的申请人搜索成功。有一名申请人被排除在外,因此共有 45 名申请人。48.9% 的申请人成功匹配到 I6 计划。在未进入 I6 项目的 23 人中,91.3% 开始了普通外科(GS)住院实习。仅从普通外科学员的情况来看,71.4% 的学员寻求并匹配到了传统或 4/3 CTS 实习项目。总之,77.8% 的学员目前正在从事心胸外科工作。该研究发现,接受综合住院医师培训面试的学员对 CT 外科领域持续保持着浓厚的兴趣。这项研究中使用的方法为跟踪受访申请人的职业选择提供了有效途径,其他项目也可采用这种方法进一步阐明职业选择和承诺水平。
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引用次数: 0
Editorial Board Page 编辑委员会页面
IF 1.4 Q3 SURGERY Pub Date : 2024-08-01 DOI: 10.1016/S2589-8450(24)00110-6
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引用次数: 0
Appendicitis tends to be complicated during the COVID-19 epidemic: A multicentre retrospective study 在 COVID-19 流行期间,阑尾炎往往比较复杂:多中心回顾性研究
IF 1.4 Q3 SURGERY Pub Date : 2024-08-01 DOI: 10.1016/j.sopen.2024.06.009

Background

In past studies, non-medical factors in the social-healthcare-patient triad associated with the prevalence of COVID-19 have led to delays in the presentation of patients with acute appendicitis and an increase in complications. However, as research progresses, there is increasing evidence of a clinical association between COVID-19 and the development of acute appendicitis.

Methods

The effect of COVID-19 prevalence and associated factors on acute appendicitis in the control (2016–2019) and exposed (2020−2023) groups was derived from a retrospective study of 3070 patients with acute appendicitis from 2016 to 2023.

Results

After the implementation of the restrictions, the rate of acute appendicitis visits in the exposed group compared to the control group dropped sharply in the initial period (P = 0.047) and recovered gradually with the relaxation of the restrictions. Similar changes occurred in the number of acute complicated appendicitis visits. In addition, after the lifting of restrictions and the COVID-19 outbreak, the proportion of acute complicated appendicitis in the exposed group increased significantly (P < 0.001) and an increase in the number of complicated appendicitis visits was observed (P < 0.001) compared with the control group. In addition, the age distribution of acute appendicitis during this period showed an ageing trend (P = 0.001).

Conclusion

COVID-19 infections may be more likely to progress to complicated appendicitis after an episode of appendicitis, even if they have been cured for the same period of time. In addition, the proportion of elderly patients with appendicitis increased after the COVID-19 epidemic.

背景在过去的研究中,与 COVID-19 流行率相关的社会-医疗-患者三方中的非医疗因素导致了急性阑尾炎患者就诊时间的延迟和并发症的增加。然而,随着研究的深入,越来越多的证据表明 COVID-19 与急性阑尾炎发病之间存在临床关联。方法通过对 2016 年至 2023 年间 3070 名急性阑尾炎患者的回顾性研究,得出 COVID-19 流行率及相关因素对对照组(2016-2019 年)和暴露组(2020-2023 年)急性阑尾炎的影响。结果实施限制措施后,与对照组相比,暴露组的急性阑尾炎就诊率在初期急剧下降(P = 0.047),并随着限制措施的放宽而逐渐恢复。急性复杂性阑尾炎的就诊人数也发生了类似的变化。此外,在解除限制和 COVID-19 爆发后,与对照组相比,暴露组的急性复杂性阑尾炎比例显著增加(P < 0.001),复杂性阑尾炎就诊人数也有所增加(P < 0.001)。此外,在此期间急性阑尾炎的年龄分布呈现出老龄化趋势(P = 0.001)。结论COVID-19 感染者在阑尾炎发作后可能更容易发展为复杂性阑尾炎,即使他们在同一时期已经治愈。此外,COVID-19 流行后,阑尾炎老年患者的比例增加。
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引用次数: 0
A novel latex patch model enables cost-effective hands-on teaching in vascular surgery 新型乳胶贴片模型实现了经济高效的血管外科实践教学
IF 1.4 Q3 SURGERY Pub Date : 2024-08-01 DOI: 10.1016/j.sopen.2024.07.003

Objectives

We developed a new simulator for hands-on teaching of vascular surgical skills, the Leipzig Latex Patch Model (LPM). This study aimed to quantify the effectiveness and acceptance of the LPM evaluated by students, as well as evaluation of the results by experienced vascular surgeons.

Methods

A prospective, single-center, single-blinded, randomized study was conducted. Fifty 5th-year medical students were randomized into two groups, first performing a patch suture on the LPM (study group) or established synthetic tissue model (control), then on porcine aorta. The second suture was videotaped and scored by two surgeons using a modified Objective Structured Assessment of Technical Skill (OSATS) score. We measured the time required for suturing; the participants completed questionnaires.

Results

Participants required significantly less time for the second suture than the first (median: LPM 30 min vs. control 28.5 min, p = 0.0026). There was no significant difference in suture time between the groups (median: 28 min vs. 30 min, p = 0.2958). There was an increase in confidence from 28 % of participants before to 58 % after the course (p < 0.0001). The cost of materials per participant was 1.05€ (LPM) vs. 8.68€ (control). The OSATS-scores of the LPM group did not differ significantly from those of the control (median: 20.5 points vs. 23.0 points, p = 0.2041).

Conclusions

This pilot study demonstrated an increase in technical skills and confidence through simulator-based teaching. Our data suggests comparable results of the LPM compared to the conventional model, as assessed by the OSATS-score. This low-cost, low-threshold training model for vascular suturing skills should make hands-on training more accessible to students and surgical residents.

Key message

We developed and validated a low-cost, low-threshold training model for vascular suturing skills. This should make hands-on training more accessible to medical students and surgical residents in the future.

目的我们开发了一种用于血管外科技能实践教学的新型模拟器--莱比锡乳胶贴片模型(LPM)。本研究旨在量化学生对 LPM 的效果和接受程度的评价,以及经验丰富的血管外科医生对结果的评价。50 名五年级医学生被随机分为两组,首先在 LPM(研究组)或已建立的合成组织模型(对照组)上进行补片缝合,然后在猪主动脉上进行补片缝合。对第二次缝合进行录像,并由两名外科医生使用改良的客观结构化技术技能评估 (OSATS) 分值进行评分。我们测量了缝合所需的时间;参与者填写了调查问卷。结果参与者第二次缝合所需的时间明显少于第一次(中位数:LPM 30 分钟 vs. 对照组 28.5 分钟,p = 0.0026)。两组的缝合时间无明显差异(中位数:28 分钟对 30 分钟,p = 0.2958)。参加者的自信心从课程前的 28% 提高到课程后的 58%(p < 0.0001)。每位学员的材料费为 1.05 欧元(LPM)对 8.68 欧元(对照组)。LPM 组的 OSATS 分数与对照组没有显著差异(中位数:20.5 分 vs. 23.0 分,p = 0.2041)。我们的数据表明,通过 OSATS 分数评估,LPM 与传统模式相比效果相当。我们开发并验证了一种低成本、低门槛的血管缝合技能培训模式。我们开发并验证了低成本、低门槛的血管缝合技能培训模式,这将使医科学生和外科住院医师今后更容易获得实践培训。
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引用次数: 0
Exploring factors impacting patient decisions in hemorrhoid surgery: A questionnaire survey in Taiwan 探索影响痔疮手术患者决定的因素:台湾问卷调查
IF 1.4 Q3 SURGERY Pub Date : 2024-08-01 DOI: 10.1016/j.sopen.2024.07.009

Background

Minimally invasive hemorrhoid surgeries like Doppler-Guided Hemorrhoidal Artery Ligation (DGHAL) and Stapled Hemorrhoidopexy (PPH) offer benefits over traditional methods. This study investigated public perceptions and attitudes towards these surgeries, exploring awareness, preferences, and influencing factors.

Methods

A detailed questionnaire was disseminated to 2011 participants from various regions of Taiwan in December 2023, gathering data on demographics, understanding of minimally invasive surgery, and attitudes towards hemorrhoid surgery. Chi-square tests were used for analysis (p < 0.05).

Results

Hemorrhoid prevalence was similar across sexes and age groups. About 70 % preferred medical centers or district hospitals for surgery. Postoperative complications were a primary concern, with significant sex differences. Approximately 70 % preferred minimally invasive surgery if costs were below NT$50,000. Medical personnel showed higher awareness of minimally invasive surgery benefits. Most participants relied on personal networks and medical social media for information.

Conclusions

The study revealed generally positive perceptions of minimally invasive hemorrhoid surgery, with cost being a significant factor. Knowledge gaps exist, particularly among non-medical personnel. Future initiatives should aim to enhance public awareness of minimally invasive surgery benefits, and policy considerations should address financial aspects of healthcare decisions.

背景多普勒引导下痔动脉结扎术(DGHAL)和带钉痔疮环切术(PPH)等微创痔疮手术比传统方法更有优势。本研究调查了公众对这些手术的看法和态度,探讨了公众对这些手术的认知、偏好和影响因素。研究方法于2023年12月向来自台湾不同地区的2011名参与者发放了详细的调查问卷,收集了人口统计学、对微创手术的理解以及对痔疮手术的态度等数据。结果不同性别和年龄组的痔疮患病率相似。约 70% 的人首选医疗中心或地区医院进行手术。术后并发症是主要问题,性别差异显著。如果费用低于新台币 50,000 元,约 70% 的人首选微创手术。医务人员对微创手术益处的认知度较高。大多数参与者依靠个人网络和医疗社交媒体获取信息。知识缺口依然存在,尤其是非医务人员。未来的举措应旨在提高公众对微创手术益处的认识,政策考虑因素应涉及医疗决策的财务方面。
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引用次数: 0
Obese adolescents have higher risk for femur fracture after motor vehicle collision 肥胖青少年在机动车碰撞后发生股骨骨折的风险更高
IF 1.4 Q3 SURGERY Pub Date : 2024-08-01 DOI: 10.1016/j.sopen.2024.07.007

Background

Previous reports identified an association between obese adolescents (OAs) and lower extremity (LE) fractures after blunt trauma. However, the type of LE fracture remains unclear. We hypothesized that OAs presenting after motor vehicle collision (MVC) have a higher risk of severe LE fracture and will require a longer length of stay (LOS) and more support services upon discharge, compared to non-OAs.

Methods

The 2017–2019 Trauma Quality Improvement Program database was queried for adolescents (12–17-years-old) presenting after MVC. The primary outcome was LE fracture. A severe fracture was defined by abbreviated injury scale ≥3. OAs were defined by a body mass index (BMI) ≥30.

Results

From 22,610 MVCs, 3325 (14.7 %) included OAs. The rate of any LE fracture was higher for OAs (21.6 % vs. 18.8 %, p < 0.001). On subset analysis the only LE fracture at higher risk in OAs was a femur fracture (13 % vs. 9.1 %, p < 0.001). After adjusting for sex and age, the risk for severe LE fracture (OR 1.34, CI 1.18–1.53, p < 0.001) was higher for OAs. OAs with a femur fracture had a longer median LOS (5 vs. 4 days, p = 0.003) and were more likely discharged with additional support services including home-health or inpatient rehabilitation (30.6 % vs. 21.4 %, p < 0.001).

Conclusion

OAs sustaining MVCs have increased associated risk of femur fractures. OAs are more likely to have a higher-grade LE injury, experience a longer LOS, and require additional support services upon discharge. Future research is needed to determine if early disposition planning with social work assistance can help shorten LOS.

背景以前的报告发现肥胖青少年(OAs)与钝性创伤后下肢(LE)骨折之间存在关联。然而,下肢骨折的类型仍不清楚。我们假设,与非肥胖青少年相比,在机动车碰撞(MVC)后出现的肥胖青少年发生严重下肢骨折的风险更高,出院时需要更长的住院时间(LOS)和更多的支持服务。方法查询了 2017-2019 年创伤质量改进计划数据库中在机动车碰撞后出现的青少年(12-17 岁)。主要结果是LE骨折。严重骨折的定义是缩写损伤量表≥3。结果在 22610 例 MVC 中,有 3325 例(14.7%)包括 OA。OA的左腿骨折率更高(21.6% vs. 18.8%,p < 0.001)。在子集分析中,OA 中唯一风险较高的 LE 骨折是股骨骨折(13% 对 9.1%,p <0.001)。在对性别和年龄进行调整后,OA 发生严重 LE 骨折的风险更高(OR 1.34,CI 1.18-1.53,p <0.001)。股骨骨折的老年患者的中位住院日更长(5 天 vs. 4 天,p = 0.003),更有可能在出院时接受额外的支持服务,包括家庭保健或住院康复(30.6 % vs. 21.4 %,p < 0.001)。OA更有可能出现更高级别的LE损伤,经历更长的LOS,并在出院时需要额外的支持服务。未来需要进行研究,以确定在社工协助下进行早期处置规划是否有助于缩短生命周期。
{"title":"Obese adolescents have higher risk for femur fracture after motor vehicle collision","authors":"","doi":"10.1016/j.sopen.2024.07.007","DOIUrl":"10.1016/j.sopen.2024.07.007","url":null,"abstract":"<div><h3>Background</h3><p>Previous reports identified an association between obese adolescents (OAs) and lower extremity (LE) fractures after blunt trauma. However, the type of LE fracture remains unclear. We hypothesized that OAs presenting after motor vehicle collision (MVC) have a higher risk of severe LE fracture and will require a longer length of stay (LOS) and more support services upon discharge, compared to non-OAs.</p></div><div><h3>Methods</h3><p>The 2017–2019 Trauma Quality Improvement Program database was queried for adolescents (12–17-years-old) presenting after MVC. The primary outcome was LE fracture. A severe fracture was defined by abbreviated injury scale ≥3. OAs were defined by a body mass index (BMI) ≥30.</p></div><div><h3>Results</h3><p>From 22,610 MVCs, 3325 (14.7 %) included OAs. The rate of any LE fracture was higher for OAs (21.6 % vs. 18.8 %, <em>p</em> &lt; 0.001). On subset analysis the only LE fracture at higher risk in OAs was a femur fracture (13 % vs. 9.1 %, <em>p</em> &lt; 0.001). After adjusting for sex and age, the risk for severe LE fracture (OR 1.34, CI 1.18–1.53, <em>p</em> &lt; 0.001) was higher for OAs. OAs with a femur fracture had a longer median LOS (5 vs. 4 days, <em>p</em> = 0.003) and were more likely discharged with additional support services including home-health or inpatient rehabilitation (30.6 % vs. 21.4 %, <em>p</em> &lt; 0.001).</p></div><div><h3>Conclusion</h3><p>OAs sustaining MVCs have increased associated risk of femur fractures. OAs are more likely to have a higher-grade LE injury, experience a longer LOS, and require additional support services upon discharge. Future research is needed to determine if early disposition planning with social work assistance can help shorten LOS.</p></div>","PeriodicalId":74892,"journal":{"name":"Surgery open science","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2589845024001064/pdfft?md5=ace7da42fe61c0c3bf03f380b9874bf5&pid=1-s2.0-S2589845024001064-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141840563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The contemporary management of perforated appendicitis in adults: To operate or wait? 成人穿孔性阑尾炎的现代治疗方法:手术还是等待?
IF 1.4 Q3 SURGERY Pub Date : 2024-08-01 DOI: 10.1016/j.sopen.2024.07.008

Objectives

The optimal management of perforated appendicitis remains controversial. Many studies advocate for antibiotics and an interval appendectomy whereas others suggest that performing an appendectomy at the time of presentation decreases post-operative morbidity. Confounding this argument further are the patients who fail non-operative management and end up requiring surgery during their initial hospitalization. This study aims to determine if early operative intervention should be considered for perforated appendicitis.

Methods

This was a retrospective review of all patients who underwent an appendectomy (both laparoscopic or open) for perforated appendicitis between 2015 and 2020 at our institution.

Results

A total of 271 patients met inclusion criteria for this study. Of this group, 250 patients underwent an immediate appendectomy whereas the remaining 21 patients underwent a trial of non-operative management and eventually required an appendectomy during their initial admission. When comparing the immediate versus delayed operative groups, there were no differences in demographic data including age and gender, and no differences in various imaging findings including AAST Grade IV or V appendicitis. Operatively, patients in the delayed group had a longer operative time (83.1 ± 32.9 vs. 64.1 ± 26.2, p = 0.01), were more likely to require an open operation (23.8 % vs. 2.8 %, p < 0.0001), and were more likely to have a drain placed intra-operatively (42.9 % vs 14.4 %, p = 0.004). While there were no differences in 30-day readmission rates, patients in the delayed group had a significantly longer hospital length of stay than patients in the immediate group (9.4 ± 7.4 vs. 3.1 ± 3.3, p = 0.008).

Conclusions

Patients undergoing an immediate appendectomy for perforated appendicitis can discharge from the hospital sooner and demonstrate no increase in post-operative morbidity suggesting that surgeons can initially manage this disease process in an operative fashion.

目标穿孔性阑尾炎的最佳治疗方法仍存在争议。许多研究主张使用抗生素并进行间隔性阑尾切除术,而另一些研究则认为在患者发病时进行阑尾切除术可降低术后发病率。非手术治疗失败并最终需要在最初住院期间进行手术的患者进一步加剧了这一争论。本研究旨在确定是否应考虑对穿孔性阑尾炎进行早期手术干预。方法这是一项回顾性研究,研究对象为2015年至2020年间在我院因穿孔性阑尾炎接受阑尾切除术(腹腔镜或开腹)的所有患者。其中,250 名患者立即进行了阑尾切除术,而其余 21 名患者在入院初期接受了非手术治疗试验,最终需要进行阑尾切除术。在比较立即手术组和延迟手术组时,人口统计学数据(包括年龄和性别)没有差异,各种影像学检查结果(包括 AAST IV 级或 V 级阑尾炎)也没有差异。手术方面,延迟手术组患者的手术时间更长(83.1 ± 32.9 vs. 64.1 ± 26.2,p = 0.01),更有可能需要开腹手术(23.8 % vs. 2.8 %,p < 0.0001),更有可能在术中放置引流管(42.9 % vs. 14.4 %,p = 0.004)。结论因阑尾炎穿孔而立即接受阑尾切除术的患者可以更快出院,术后发病率也没有增加,这表明外科医生最初可以通过手术来处理这种疾病。
{"title":"The contemporary management of perforated appendicitis in adults: To operate or wait?","authors":"","doi":"10.1016/j.sopen.2024.07.008","DOIUrl":"10.1016/j.sopen.2024.07.008","url":null,"abstract":"<div><h3>Objectives</h3><p>The optimal management of perforated appendicitis remains controversial. Many studies advocate for antibiotics and an interval appendectomy whereas others suggest that performing an appendectomy at the time of presentation decreases post-operative morbidity. Confounding this argument further are the patients who fail non-operative management and end up requiring surgery during their initial hospitalization. This study aims to determine if early operative intervention should be considered for perforated appendicitis.</p></div><div><h3>Methods</h3><p>This was a retrospective review of all patients who underwent an appendectomy (both laparoscopic or open) for perforated appendicitis between 2015 and 2020 at our institution.</p></div><div><h3>Results</h3><p>A total of 271 patients met inclusion criteria for this study. Of this group, 250 patients underwent an immediate appendectomy whereas the remaining 21 patients underwent a trial of non-operative management and eventually required an appendectomy during their initial admission. When comparing the immediate versus delayed operative groups, there were no differences in demographic data including age and gender, and no differences in various imaging findings including AAST Grade IV or V appendicitis. Operatively, patients in the delayed group had a longer operative time (83.1 ± 32.9 vs. 64.1 ± 26.2, <em>p</em> = 0.01), were more likely to require an open operation (23.8 % vs. 2.8 %, <em>p</em> &lt; 0.0001), and were more likely to have a drain placed intra-operatively (42.9 % vs 14.4 %, <em>p</em> = 0.004). While there were no differences in 30-day readmission rates, patients in the delayed group had a significantly longer hospital length of stay than patients in the immediate group (9.4 ± 7.4 vs. 3.1 ± 3.3, <em>p</em> = 0.008).</p></div><div><h3>Conclusions</h3><p>Patients undergoing an immediate appendectomy for perforated appendicitis can discharge from the hospital sooner and demonstrate no increase in post-operative morbidity suggesting that surgeons can initially manage this disease process in an operative fashion.</p></div>","PeriodicalId":74892,"journal":{"name":"Surgery open science","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2589845024001052/pdfft?md5=657efceb1c297f7262f0371da08ba08e&pid=1-s2.0-S2589845024001052-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141838448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Predictors of occult metastases in potentially Resectable pancreatic ductal adenocarcinoma 潜在可切除胰腺导管腺癌隐匿性转移的预测因素
IF 1.4 Q3 SURGERY Pub Date : 2024-08-01 DOI: 10.1016/j.sopen.2024.07.010

Background

Patients with resectable (R) or borderline resectable (BR) pancreatic ductal adenocarcinoma (PDAC) sometimes show unexpected liver, peritoneal, and para-aortic lymph node metastases intraoperatively. Despite radical pancreatectomy, a nonnegligible number of patients relapse within 6 months after surgery. The aim of this study was to identify the preoperative predictors of occult metastases (OM), defined as intraoperative distant metastases or within 6 months after pancreatectomy.

Materials and methods

This study included patients with R and BR PDAC who underwent curative-intent pancreatectomy or staging laparoscopy between 2006 and 2021. Multivariate logistic regression and Cox hazard analyses were performed to identify the preoperative predictors of OM and to assess the impact of these factors on prognosis after pancreatectomy.

Results

Of the 279 patients, OM was observed intraoperatively in 47 and postoperatively in 34. In the OM group, there were no differences in prognosis between patients who had intraoperative metastases and recurrence within 6 months (median survival time [MST], 18.1 vs. 12.9 months), and between patients who underwent pancreatectomy and those who did not (MST, 13.9 vs. 18.1 months). Preoperative tumor size ≥22 mm (odds ratio [OR], 2.03; 95 % confidence interval [CI], 1.16–3.53; p = 0.013) and preoperative CA19–9 level ≥ 118.8 U/mL (OR, 2.64; 95 % CI, 1.22–5.73; p = 0.014) were significant predictors of OM. Additionally, positive OM predictors were strong independent prognostic factors for overall survival after pancreatectomy (hazard ratio, 2.47; 95 % CI, 1.54–3.98; p < 0.001).

Conclusion

Multidisciplinary treatment strategies should be considered for patients with predictors of OM to avoid inappropriate surgical interventions.

背景可切除(R)或边缘可切除(BR)胰腺导管腺癌(PDAC)患者有时会在术中出现意想不到的肝脏、腹膜和主动脉旁淋巴结转移。尽管进行了根治性胰腺切除术,但仍有相当数量的患者在术后 6 个月内复发。本研究旨在确定隐匿性转移(OM)的术前预测因素,即术中远处转移或胰腺切除术后 6 个月内的隐匿性转移。结果 在 279 例患者中,47 例在术中观察到 OM,34 例在术后观察到 OM。在OM组中,术中出现转移和6个月内复发的患者(中位生存时间[MST],18.1个月对12.9个月)以及接受胰腺切除术和未接受胰腺切除术的患者(中位生存时间,13.9个月对18.1个月)的预后无差异。术前肿瘤大小≥22 mm(几率比 [OR],2.03;95 % 置信区间 [CI],1.16-3.53;P = 0.013)和术前 CA19-9 水平≥118.8 U/mL(OR,2.64;95 % CI,1.22-5.73;P = 0.014)是 OM 的显著预测因素。此外,阳性 OM 预测因子是胰腺切除术后总生存率的强有力的独立预后因素(危险比,2.47;95 % CI,1.54-3.98;p < 0.001)。
{"title":"Predictors of occult metastases in potentially Resectable pancreatic ductal adenocarcinoma","authors":"","doi":"10.1016/j.sopen.2024.07.010","DOIUrl":"10.1016/j.sopen.2024.07.010","url":null,"abstract":"<div><h3>Background</h3><p>Patients with resectable (R) or borderline resectable (BR) pancreatic ductal adenocarcinoma (PDAC) sometimes show unexpected liver, peritoneal, and para-aortic lymph node metastases intraoperatively. Despite radical pancreatectomy, a nonnegligible number of patients relapse within 6 months after surgery. The aim of this study was to identify the preoperative predictors of occult metastases (OM), defined as intraoperative distant metastases or within 6 months after pancreatectomy.</p></div><div><h3>Materials and methods</h3><p>This study included patients with R and BR PDAC who underwent curative-intent pancreatectomy or staging laparoscopy between 2006 and 2021. Multivariate logistic regression and Cox hazard analyses were performed to identify the preoperative predictors of OM and to assess the impact of these factors on prognosis after pancreatectomy.</p></div><div><h3>Results</h3><p>Of the 279 patients, OM was observed intraoperatively in 47 and postoperatively in 34. In the OM group, there were no differences in prognosis between patients who had intraoperative metastases and recurrence within 6 months (median survival time [MST], 18.1 vs. 12.9 months), and between patients who underwent pancreatectomy and those who did not (MST, 13.9 vs. 18.1 months). Preoperative tumor size ≥22 mm (odds ratio [OR], 2.03; 95 % confidence interval [CI], 1.16–3.53; <em>p</em> = 0.013) and preoperative CA19–9 level ≥ 118.8 U/mL (OR, 2.64; 95 % CI, 1.22–5.73; <em>p</em> = 0.014) were significant predictors of OM. Additionally, positive OM predictors were strong independent prognostic factors for overall survival after pancreatectomy (hazard ratio, 2.47; 95 % CI, 1.54–3.98; <em>p</em> &lt; 0.001).</p></div><div><h3>Conclusion</h3><p>Multidisciplinary treatment strategies should be considered for patients with predictors of OM to avoid inappropriate surgical interventions.</p></div>","PeriodicalId":74892,"journal":{"name":"Surgery open science","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2589845024001088/pdfft?md5=b7896d19c52de72043a7a8251d0df8a9&pid=1-s2.0-S2589845024001088-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141841103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Trauma patients with metastatic cancer undergoing emergent surgery: A matched cohort analysis 接受紧急手术的转移性癌症创伤患者:匹配队列分析
IF 1.4 Q3 SURGERY Pub Date : 2024-07-17 DOI: 10.1016/j.sopen.2024.07.005

Background

There is a paucity of literature guiding trauma surgeons in the care of patients with active metastatic cancer (MC). Even less is known regarding outcomes for MC patients requiring emergent surgery after trauma. We hypothesized that trauma patients with active Metastatic Cancer (MC) have an increased mortality rate and undergo increased rates of withdrawal of care (WoC) within 72-hours following emergent operations, compared to similarly matched patients without MC.

Methods

Patients with active MC at the time of traumatic injury were matched 1:2 against patients without active MC based on demographics, comorbidities, vital signs on admission, and injury profile.

Results

From 43,826 patients, 0.2 % had MC. After matching 39 MC patients to 78 without MC, there was no difference in demographics, comorbidities, injury severity score, mechanism of injury, vitals on admission (blood pressure, heart rate, respiration rate) and need for blood transfusion (all p > 0.05). Compared to patients without MC, patients with MC had higher rates and associated risk of death during index hospitalization (38.5 % vs. 15.2 %, p = 0.005; OR 3.49, CI 1.43–8.51, p = 0.006), as well as a higher rate and associated risk of WoC within 72-hours (12.8 % vs. 1.3 %, p = 0.007; OR 11.47, CI 1.29–101.93, p = 0.029).

Conclusion

Trauma patients with MC requiring emergent thoracic or abdominal surgery have a high risk of death and an over ten-fold higher associated risk for WoC within the first three days. In some cases, palliative care consultation should be considered, and counseling should be offered to this high-risk trauma population to enable individualized and patient-centric decisions.

Key message

This research highlights the importance of a multidisciplinary team consisting of trauma surgeons, oncologist, and palliative care physicians in caring for the high-risk trauma patients with disseminated cancer requiring urgent surgery.

背景指导创伤外科医生护理活动性转移性癌症(MC)患者的文献极少。对于创伤后需要紧急手术的转移性癌症患者的治疗效果更是知之甚少。我们假设,与无转移性癌症(MC)的类似配对患者相比,患有活动性转移性癌症(MC)的创伤患者死亡率会增加,并且在急诊手术后 72 小时内的停诊率(WoC)也会增加。方法根据人口统计学、合并症、入院时的生命体征和伤情,将创伤受伤时患有活动性MC的患者与无活动性MC的患者进行1:2配对。将 39 名 MC 患者与 78 名无 MC 患者进行配对后,发现两者在人口统计学、合并症、损伤严重程度评分、损伤机制、入院时生命体征(血压、心率、呼吸频率)和输血需求方面均无差异(所有 p 均为 0.05)。与没有 MC 的患者相比,有 MC 的患者在指数住院期间的死亡率和相关风险更高(38.5 % vs. 15.2 %,p = 0.005;OR 3.49,CI 1.43-8.51,p = 0.006),72 小时内 WoC 的发生率和相关风险也更高(12.结论需要紧急进行胸腔或腹腔手术的 MC 重创患者死亡风险高,前三天内发生 WoC 的相关风险高出十倍以上。在某些情况下,应考虑姑息治疗咨询,并为这一高风险创伤人群提供咨询,以便做出个性化和以患者为中心的决定。这项研究强调了由创伤外科医生、肿瘤科医生和姑息治疗医生组成的多学科团队在护理需要紧急手术的高风险扩散性癌症创伤患者方面的重要性。
{"title":"Trauma patients with metastatic cancer undergoing emergent surgery: A matched cohort analysis","authors":"","doi":"10.1016/j.sopen.2024.07.005","DOIUrl":"10.1016/j.sopen.2024.07.005","url":null,"abstract":"<div><h3>Background</h3><p>There is a paucity of literature guiding trauma surgeons in the care of patients with active metastatic cancer (MC). Even less is known regarding outcomes for MC patients requiring emergent surgery after trauma. We hypothesized that trauma patients with active Metastatic Cancer (MC) have an increased mortality rate and undergo increased rates of withdrawal of care (WoC) within 72-hours following emergent operations, compared to similarly matched patients without MC.</p></div><div><h3>Methods</h3><p>Patients with active MC at the time of traumatic injury were matched 1:2 against patients without active MC based on demographics, comorbidities, vital signs on admission, and injury profile.</p></div><div><h3>Results</h3><p>From 43,826 patients, 0.2 % had MC. After matching 39 MC patients to 78 without MC, there was no difference in demographics, comorbidities, injury severity score, mechanism of injury, vitals on admission (blood pressure, heart rate, respiration rate) and need for blood transfusion (all <em>p</em> &gt; 0.05). Compared to patients without MC, patients with MC had higher rates and associated risk of death during index hospitalization (38.5 % vs. 15.2 %, <em>p</em> = 0.005; OR 3.49, CI 1.43–8.51, <em>p</em> = 0.006), as well as a higher rate and associated risk of WoC within 72-hours (12.8 % vs. 1.3 %, <em>p</em> = 0.007; OR 11.47, CI 1.29–101.93, <em>p</em> = 0.029).</p></div><div><h3>Conclusion</h3><p>Trauma patients with MC requiring emergent thoracic or abdominal surgery have a high risk of death and an over ten-fold higher associated risk for WoC within the first three days. In some cases, palliative care consultation should be considered, and counseling should be offered to this high-risk trauma population to enable individualized and patient-centric decisions.</p></div><div><h3>Key message</h3><p>This research highlights the importance of a multidisciplinary team consisting of trauma surgeons, oncologist, and palliative care physicians in caring for the high-risk trauma patients with disseminated cancer requiring urgent surgery.</p></div>","PeriodicalId":74892,"journal":{"name":"Surgery open science","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2589845024001015/pdfft?md5=08d852ce689823b886bcac2a36e4391a&pid=1-s2.0-S2589845024001015-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141636659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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