Pub Date : 2022-01-01DOI: 10.4168/aard.2022.10.2.118
Ha Kyung Lee, Jin Gyu Lim, Ji Soo Park, S. Shin, S. Kwon, D. Suh
{"title":"An infant with subglottic cysts presenting as abruptly-progressed stridor and respiratory distress 2 months after extubation","authors":"Ha Kyung Lee, Jin Gyu Lim, Ji Soo Park, S. Shin, S. Kwon, D. Suh","doi":"10.4168/aard.2022.10.2.118","DOIUrl":"https://doi.org/10.4168/aard.2022.10.2.118","url":null,"abstract":"","PeriodicalId":7548,"journal":{"name":"Allergy, Asthma & Respiratory Disease","volume":"23 1","pages":""},"PeriodicalIF":0.2,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74102462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-12-30DOI: 10.21203/rs.3.rs-1207547/v1
Y. Park, You Na Park, J. Moon, Hyo-Bin Kim, Meeyong Shin, Eun Lee, Chul-Hong Kim, Ju Suk Lee, Yong Ju Lee, B. Kim, H. Kim, Sungsu Jung, Yunsun Kim, Sangyoung Kim, C. Park, Ju-Hee Seo, J. Shim, I. Sol, M. Sung, D. Song, Y. Ahn, H. Oh, Jinho Yu, K. Lee, G. Jang, Y. Jang, H. Chung, E. Chung, S. Choi, Yunjung Choi, M. Han, Jin Tack Kim, Chang-Keun Kim, H. Yang
Background: Mycoplasma pneumoniae pneumonia (MP) is a major cause of community acquired pneumonia (CAP) in children and it is known to be associated with extrapulmonary manifestations (EPM). The incidence and risk factors of EPM in children are not known.Methods: This is a retrospective study involving 65,243 pediatric CAP patients between 2010 and 2015 at 23 nationwide hospitals was conducted in South Korea. The medical records were reviewed to collect the information regarding the clinical characteristics, radiological results, and laboratory findings. In total, 9,190 children with MP were identified and included in the analysis. Logistic regression with multivariable analysis was performed to evaluate the risk factors associated with EPM in MP.Results: The mean age of the enrolled patients with MP was 64.3±39.8 months, and the proportion of male patients was 49.5%. The incidence of EPM was 23.9% and included elevation of liver enzymes (18.1%), mucocutaneous manifestations (4.4%), proteinuria (4.1%), cardiovascular and neurologic manifestation (0.4%), hematologic manifestation (0.2%) and arthritis (0.2%). Statistical analysis showed that mucocutaneous manifestations were significantly increased with elevated alanine aminotransferase (adjusted odds ratio [aOR] 3.623, 95% confidence intervals [CI] 1.933-6.790) and atopic sensitization (aOR 2.973, 95% CI 1.615-5.475) and decreased with respiratory virus co-infection (aOR 0.273, 95% CI 0.084-0.887). Elevated liver enzymes was significantly associated with the elevation of lactate dehydrogenase (aOR 3.055, 95% CI 2.257-4.137) and presence of pleural effusion (aOR 2.635, 95% CI 1.767-3.930) and proteinuria with respiratory virus co-infection (aOR 2.245, 95% CI 1.113-4.527). Conclusions: About 24% of pediatric MP patients were identified with various EPM. Since risk factors associated with each EPM was different, it is necessary to evaluate the various clinical aspects and findings of MP to predict and prepare for the occurrence of EPM.
背景:肺炎支原体肺炎(MP)是儿童社区获得性肺炎(CAP)的主要病因，已知与肺外表现(EPM)相关。儿童EPM的发病率和危险因素尚不清楚。方法:这是一项回顾性研究，涉及韩国23家全国性医院2010年至2015年期间65243例儿科CAP患者。回顾病历，收集有关临床特征、放射学结果和实验室检查结果的信息。共有9190名MP患儿被确定并纳入分析。采用Logistic回归与多变量分析来评价MP中EPM的相关危险因素。结果:纳入的MP患者平均年龄为64.3±39.8个月，男性占49.5%。EPM的发生率为23.9%，包括肝酶升高(18.1%)、粘膜皮肤表现(4.4%)、蛋白尿(4.1%)、心血管和神经表现(0.4%)、血液学表现(0.2%)和关节炎(0.2%)。统计分析显示，丙氨酸转氨酶升高(调整优势比[aOR] 3.623, 95%可信区间[CI] 1.933 ~ 6.790)和特应性致敏(调整优势比[aOR] 2.973, 95% CI 1.615 ~ 5.475)显著增加了粘膜皮肤表现，呼吸道病毒合并感染(调整优势比[aOR] 0.273, 95% CI 0.084 ~ 0.887)显著降低了粘膜皮肤表现。肝酶升高与乳酸脱氢酶升高(aOR 3.055, 95% CI 2.257-4.137)、胸膜积液(aOR 2.635, 95% CI 1.767-3.930)和伴有呼吸道病毒合并感染的蛋白尿(aOR 2.245, 95% CI 1.113-4.527)显著相关。结论:约24%的小儿MP患者被鉴定为各种EPM。由于与每一种EPM相关的危险因素不同，因此有必要对MP的各种临床方面和表现进行评估，以预测EPM的发生并为其做好准备。
{"title":"The Incidence and Risk Factors of Extrapulmonary Manifestations in Mycoplasma Pneumoniae Pneumonia","authors":"Y. Park, You Na Park, J. Moon, Hyo-Bin Kim, Meeyong Shin, Eun Lee, Chul-Hong Kim, Ju Suk Lee, Yong Ju Lee, B. Kim, H. Kim, Sungsu Jung, Yunsun Kim, Sangyoung Kim, C. Park, Ju-Hee Seo, J. Shim, I. Sol, M. Sung, D. Song, Y. Ahn, H. Oh, Jinho Yu, K. Lee, G. Jang, Y. Jang, H. Chung, E. Chung, S. Choi, Yunjung Choi, M. Han, Jin Tack Kim, Chang-Keun Kim, H. Yang","doi":"10.21203/rs.3.rs-1207547/v1","DOIUrl":"https://doi.org/10.21203/rs.3.rs-1207547/v1","url":null,"abstract":"\u0000 Background: Mycoplasma pneumoniae pneumonia (MP) is a major cause of community acquired pneumonia (CAP) in children and it is known to be associated with extrapulmonary manifestations (EPM). The incidence and risk factors of EPM in children are not known.Methods: This is a retrospective study involving 65,243 pediatric CAP patients between 2010 and 2015 at 23 nationwide hospitals was conducted in South Korea. The medical records were reviewed to collect the information regarding the clinical characteristics, radiological results, and laboratory findings. In total, 9,190 children with MP were identified and included in the analysis. Logistic regression with multivariable analysis was performed to evaluate the risk factors associated with EPM in MP.Results: The mean age of the enrolled patients with MP was 64.3±39.8 months, and the proportion of male patients was 49.5%. The incidence of EPM was 23.9% and included elevation of liver enzymes (18.1%), mucocutaneous manifestations (4.4%), proteinuria (4.1%), cardiovascular and neurologic manifestation (0.4%), hematologic manifestation (0.2%) and arthritis (0.2%). Statistical analysis showed that mucocutaneous manifestations were significantly increased with elevated alanine aminotransferase (adjusted odds ratio [aOR] 3.623, 95% confidence intervals [CI] 1.933-6.790) and atopic sensitization (aOR 2.973, 95% CI 1.615-5.475) and decreased with respiratory virus co-infection (aOR 0.273, 95% CI 0.084-0.887). Elevated liver enzymes was significantly associated with the elevation of lactate dehydrogenase (aOR 3.055, 95% CI 2.257-4.137) and presence of pleural effusion (aOR 2.635, 95% CI 1.767-3.930) and proteinuria with respiratory virus co-infection (aOR 2.245, 95% CI 1.113-4.527). Conclusions: About 24% of pediatric MP patients were identified with various EPM. Since risk factors associated with each EPM was different, it is necessary to evaluate the various clinical aspects and findings of MP to predict and prepare for the occurrence of EPM.","PeriodicalId":7548,"journal":{"name":"Allergy, Asthma & Respiratory Disease","volume":"17 1","pages":""},"PeriodicalIF":0.2,"publicationDate":"2021-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75319866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-07-01DOI: 10.4168/aard.2021.9.3.136
Seung Won Lee, S. Moon, D. Yon
Purpose: There are limited data on the epidemiological and clinical characteristics and outcomes in Korean patients with labora tory-confirmed coronavirus disease 2019 (COVID-19). We aimed to describe the epidemiological and clinical characteristics and out comes of patients with COVID-19 using the Korean nationwide multicenter database. Methods: In this nationwide multicenter study, we included all confirmed patients of COVID-19 in South Korea from February 1 to April 30, 2020. Subjects were classified into 3 age groups: those at younger than 10 years (children), 10 to 20 years (adolescents), and 20 years or more (adults). Cases were confirmed by laboratory testing using real-time reverse transcriptase-polymerase chain reac tion assay and analyzed for epidemiological and clinical features and outcomes. Patents were followed up until April 30, 2020. Results: Of 5,628 patients with COVID-19 (2,320 males [41.2%] and 3,308 females [58.8%]), there were 66 children (1.2%), 206 ado lescents (3.7%), and 5,356 adults (95.2%). The common comorbidities were hypertension (1,201, 21.3%), diabetes (691, 12.3%), de mentia (224, 4.0%), chronic heart disease (179, 3.2%), cancer (145, 2.6%), and asthma (128, 2.3%). The common presenting symp toms were cough (2,341, 41.6%), sputum (1,619, 28.8%), fever (1,305, 23.2%), headache (967, 17.2%), myalgia (926, 16.5%), and pha ryngodynia (881, 15.7%). One hundred sixty-five patients (2.1%) were confirmed as having moderate or severe COVID-19 and 118 (2.1%) as having severe COVID-19. Conclusion: Our descriptive study provides the epidemiological and clinical characteristics and outcomes of patients with labora tory-confirmed COVID-19 in South Korea. (Allergy Asthma Respir Dis 2021;9:136-140)
{"title":"Epidemiological and clinical characteristics of 5,628 patients with coronavirus disease 2019 in South Korea: A nationwide multicenter study","authors":"Seung Won Lee, S. Moon, D. Yon","doi":"10.4168/aard.2021.9.3.136","DOIUrl":"https://doi.org/10.4168/aard.2021.9.3.136","url":null,"abstract":"Purpose: There are limited data on the epidemiological and clinical characteristics and outcomes in Korean patients with labora\u001ftory-confirmed coronavirus disease 2019 (COVID-19). We aimed to describe the epidemiological and clinical characteristics and out\u001fcomes of patients with COVID-19 using the Korean nationwide multicenter database.\u0000Methods: In this nationwide multicenter study, we included all confirmed patients of COVID-19 in South Korea from February 1 to April 30, 2020. Subjects were classified into 3 age groups: those at younger than 10 years (children), 10 to 20 years (adolescents), and 20 years or more (adults). Cases were confirmed by laboratory testing using real-time reverse transcriptase-polymerase chain reac\u001ftion assay and analyzed for epidemiological and clinical features and outcomes. Patents were followed up until April 30, 2020.\u0000Results: Of 5,628 patients with COVID-19 (2,320 males [41.2%] and 3,308 females [58.8%]), there were 66 children (1.2%), 206 ado\u001flescents (3.7%), and 5,356 adults (95.2%). The common comorbidities were hypertension (1,201, 21.3%), diabetes (691, 12.3%), de\u001fmentia (224, 4.0%), chronic heart disease (179, 3.2%), cancer (145, 2.6%), and asthma (128, 2.3%). The common presenting symp\u001ftoms were cough (2,341, 41.6%), sputum (1,619, 28.8%), fever (1,305, 23.2%), headache (967, 17.2%), myalgia (926, 16.5%), and pha\u001fryngodynia (881, 15.7%). One hundred sixty-five patients (2.1%) were confirmed as having moderate or severe COVID-19 and 118 (2.1%) as having severe COVID-19.\u0000Conclusion: Our descriptive study provides the epidemiological and clinical characteristics and outcomes of patients with labora\u001ftory-confirmed COVID-19 in South Korea. (Allergy Asthma Respir Dis 2021;9:136-140)","PeriodicalId":7548,"journal":{"name":"Allergy, Asthma & Respiratory Disease","volume":"7 1","pages":""},"PeriodicalIF":0.2,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90279424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.4168/aard.2021.9.3.171
K. Ahn, So-Hee Lee, Sun-Sin Kim
{"title":"The effect of changes in total body fat amount and abdominal fat ratio on lung function decline in healthy adults","authors":"K. Ahn, So-Hee Lee, Sun-Sin Kim","doi":"10.4168/aard.2021.9.3.171","DOIUrl":"https://doi.org/10.4168/aard.2021.9.3.171","url":null,"abstract":"","PeriodicalId":7548,"journal":{"name":"Allergy, Asthma & Respiratory Disease","volume":"20 1","pages":""},"PeriodicalIF":0.2,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84563178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.4168/AARD.2021.9.1.12
Hyun Joo Lee, J. Park, Jae Min Kim, Ji Hye Kim, H. Baek
Purpose: Respiratory virus infection is a common cause of hospitalization in children. Rapid testing for respiratory viruses, such as the FilmArray method, can be clinically useful. However, insufficient evidence exists to support its use in standard clinical care. Methods: We retrospectively analyzed data from children under 18 years old who received the multiplex real-time polymerase chain reaction array (multiplex RT-PCR) method in 2017 and by FilmArray respiratory panel (FilmArray RP) in 2018. Results: Between January, 2017 and December, 2018, we reviewed data from 1,480 hospitalized children. The number of children with virus detection in respiratory viral PCR was 523 in the multiplex RT-PCR method and 419 in the FilmArray method. Seasonal virus outbreak patterns were similar to those of Korea Centers for Disease Control and Prevention in both groups. There was no differ-ence between the 2 groups in the mean length of hospital stay. The time from admission to isolation by influenza infection was sig-nificantly shorter in the FilmArray group than in the multiplex RT-PCR group among patients who were not diagnosed with influenza infection by rapid antigen test at the time of admission. Conclusion: The use of FilmArray method for respiratory viruses did not diminish length of hospital stay. However, the FilmArray method may quickly detect the prevalence of respiratory infection and aid in clinical treatment. In addition, it was related with a re-duced time from admission to isolation by influenza infection in hospitalized children who were not identified with influenza infection by rapid antigen test at the time of admission. ( Allergy Asthma Respir Dis 2021;9:12-20 )
{"title":"Clinical efficacy of respiratory virus detection by using the FilmArray method in children admitted with respiratory infection","authors":"Hyun Joo Lee, J. Park, Jae Min Kim, Ji Hye Kim, H. Baek","doi":"10.4168/AARD.2021.9.1.12","DOIUrl":"https://doi.org/10.4168/AARD.2021.9.1.12","url":null,"abstract":"Purpose: Respiratory virus infection is a common cause of hospitalization in children. Rapid testing for respiratory viruses, such as the FilmArray method, can be clinically useful. However, insufficient evidence exists to support its use in standard clinical care. Methods: We retrospectively analyzed data from children under 18 years old who received the multiplex real-time polymerase chain reaction array (multiplex RT-PCR) method in 2017 and by FilmArray respiratory panel (FilmArray RP) in 2018. Results: Between January, 2017 and December, 2018, we reviewed data from 1,480 hospitalized children. The number of children with virus detection in respiratory viral PCR was 523 in the multiplex RT-PCR method and 419 in the FilmArray method. Seasonal virus outbreak patterns were similar to those of Korea Centers for Disease Control and Prevention in both groups. There was no differ-ence between the 2 groups in the mean length of hospital stay. The time from admission to isolation by influenza infection was sig-nificantly shorter in the FilmArray group than in the multiplex RT-PCR group among patients who were not diagnosed with influenza infection by rapid antigen test at the time of admission. Conclusion: The use of FilmArray method for respiratory viruses did not diminish length of hospital stay. However, the FilmArray method may quickly detect the prevalence of respiratory infection and aid in clinical treatment. In addition, it was related with a re-duced time from admission to isolation by influenza infection in hospitalized children who were not identified with influenza infection by rapid antigen test at the time of admission. ( Allergy Asthma Respir Dis 2021;9:12-20 )","PeriodicalId":7548,"journal":{"name":"Allergy, Asthma & Respiratory Disease","volume":"78 1","pages":""},"PeriodicalIF":0.2,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75523786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.4168/aard.2021.9.4.208
Jae Hwa Jung, G. Kim, Mireu Park, Soo-Yeon Kim, Min Jung Kim, Yong Ju Lee, Y. Kim, K. Kim, M. Sohn
{"title":"Changes in allergen sensitization in children with allergic diseases in the 1980 to 2019","authors":"Jae Hwa Jung, G. Kim, Mireu Park, Soo-Yeon Kim, Min Jung Kim, Yong Ju Lee, Y. Kim, K. Kim, M. Sohn","doi":"10.4168/aard.2021.9.4.208","DOIUrl":"https://doi.org/10.4168/aard.2021.9.4.208","url":null,"abstract":"","PeriodicalId":7548,"journal":{"name":"Allergy, Asthma & Respiratory Disease","volume":"517 1","pages":""},"PeriodicalIF":0.2,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77148474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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