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Micro RNAs In Periodontal Disease – A Review 牙周病中的微rna研究进展
Pub Date : 2020-04-21 DOI: 10.22452/ADUM.VOL27NO3
M. Varghese, Thomas George Valliaveettil, A. George, Saranya Rajan
microRNAs (miRNAs) constitute a family of small, non-coding RNA molecules that regulate gene expression and protein expression. microRNAs have influence on a broad range of physiologic and pathologic conditions. They are also considered as promising biomarkers especially when they are secreted extracellularly. In the inflammatory pathways, they dysregulate the molecular processes and contribute to the development of chronic inflammatory diseases including periodontitis. In this review, we provide an overview of miRNA characteristics, biogenesis, mechanisms of action and profiling methods. In addition, the role of miRNAs in the pathobiology of periodontitis, especially those pertaining to the cellular and molecular pathways of inflammation has been considered to enhance our understanding of the pathobiology of periodontitis.
microRNAs (miRNAs)是一类调节基因表达和蛋白质表达的非编码小RNA分子。microRNAs对广泛的生理和病理条件有影响。它们也被认为是有前途的生物标志物,特别是当它们在细胞外分泌时。在炎症通路中,它们调节分子过程失调,促进包括牙周炎在内的慢性炎症性疾病的发展。本文综述了miRNA的特征、生物发生、作用机制和分析方法。此外,mirna在牙周炎病理生物学中的作用,特别是那些与炎症的细胞和分子途径有关的mirna已被认为可以增强我们对牙周炎病理生物学的理解。
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引用次数: 0
Management of Mandibular Body Fracture in an Eighteen-Month Old Child - A Case Report 一例18个月大儿童下颌骨骨折的治疗
Pub Date : 2020-01-29 DOI: 10.22452/ADUM.VOL27NO2
J. Samson, C. J. Venkatakrishnan, Bhanumurthy Lokesh, J. Philip
With the advancement of the transportation system and improvement in road conditions, the number of high- velocity accidents has also increased. Almost all of these reported cases involve individuals who had travelled in vehicles without adhering to personal protection standards and with rash driving. Injuries to the facial region can be profoundly disturbing and particularly in children. Parents find it very distressing to see their child in pain with a disfigured or injured face. It is difficult to manage such crying & sometimes uncontrollable children. The most commonly injured facial bones are Nasal, Zygomatic and the Mandible. The incidence of facial bone fracture in children is uncommon, and we present a case report of an 18- month old child with a history of road traffic accident and swelling on the right side of the face. Intraoral examination shows limited mouth opening with submucosal ecchymosis in the right buccal mucosa and based on clinical and computed tomographic scan working diagnosis of fracture in the right body of the mandible was arrived. The child was surgically treated with the circum-mandibular wiring. After three weeks the splint was removed. The injury healed without complications in the post-operative period.
随着交通系统的发展和道路状况的改善,高速事故的数量也在增加。几乎所有这些报告的病例都涉及未遵守个人防护标准和鲁莽驾驶的个人。面部区域的损伤可能会令人深感不安,尤其是儿童。看到孩子面部毁容或受伤,父母感到非常痛苦。很难控制这样的哭闹&有时是无法控制的孩子。最常见的面部骨骼损伤是鼻骨、颧骨和下颌骨。儿童面部骨折的发生率并不常见,我们报告了一例18个月大的儿童,有道路交通事故史,面部右侧肿胀。口腔内检查显示右颊粘膜有粘膜下瘀斑,开口受限,根据临床和计算机断层扫描,对右下颌骨骨折进行了工作诊断。这名儿童接受了下颌周围金属丝的手术治疗。三周后夹板被取下。术后伤口愈合,无并发症。
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引用次数: 0
Cytomorphologic Analysis of Wet and Spray Fixation Methods in Oral Exfoliative Cytology 口腔脱落细胞学湿式和喷雾固定方法的细胞形态学分析
Pub Date : 2020-01-28 DOI: 10.22452/ADUM.VOL27NO1
Supriya Hulimane, M. Shaila
For a long time, oral exfoliative cytology (OEC) has been implemented as an effective preliminary diagnostic tool for pathological lesions and various methods for fixation of the cytology specimens have been studied. The present study was undertaken to compare the efficacy between the wet and spray type of fixation methods for Papanicolaou (PAP) stained oral cytosmears. The study comprised of 45 healthy subjects in the age group of 20-25 yrs. For each subject, two smears were collected from the buccal mucosa and subjected to wet and spray fixation methods respectively. Both the smears were stained using a commercial Rapid Pap Kit. Smears were observed microscopically and evaluated for cytomorphological features involving uniformity of staining, cellular morphology, nuclear morphology, cellular staining, nuclear staining and presence of impurities. Comparisons were made between the two methods of fixation and statistically analysed using McNemar non-parametric test. Cells were evenly distributed in wet-fixed smears (n=38, 95%) compared to spray fixed smears (n=19, 47.5%). Wet-fixed smears showed lesser impurities (n=13, 32.5%) than spray fixed smears (n=27, 67.5%).  However, other parameters such as cytological and nuclear morphology, staining of cytoplasm and nucleus were found to be not significant when compared between the two methods of fixation (p<0.05). The study shows that wet-fixed smears have better cellular distribution and relatively fewer impurities when compared to the spray fixed smears. The method of wet-fixed smears may be used as an alternative to spray fixed smears. A larger sample size may be required for further validation.
长期以来,口腔脱落细胞学(OEC)一直是病理病变的有效初步诊断工具,并对各种固定细胞学标本的方法进行了研究。本研究旨在比较湿法和喷雾式固定方法对巴氏染色口腔细胞涂片的疗效。该研究由45名20-25岁年龄组的健康受试者组成。对于每个受试者,从颊粘膜采集两份涂片,并分别采用湿法和喷雾固定法。使用商业快速巴氏试剂盒对两种涂片进行染色。显微镜下观察涂片,并评估细胞形态特征,包括染色均匀性、细胞形态、细胞核形态、细胞染色、细胞核染色和杂质的存在。对两种固定方法进行比较,并使用McNemar非参数检验进行统计学分析。与喷雾固定涂片(n=19,47.5%)相比,细胞在湿固定涂片中均匀分布(n=38,95%)。湿固定涂片显示出比喷雾固定涂片更少的杂质(n=13,32.5%)(n=27,67.5%)。然而,其他参数,如细胞学和核形态,两种固定方法比较,细胞质和细胞核染色不显著(p<0.05)。研究表明,湿固定涂片与喷雾固定涂片相比,细胞分布更好,杂质相对较少。湿固定涂抹法可作为喷雾固定涂抹法的替代方法。进一步验证可能需要更大的样本量。
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引用次数: 0
Diagnosis and Treatment Considerations of Orthodontic Miniscrews in Camouflage Treatment of Adult Class III Malocclusions by Distalization of the Mandibular Dentition- A Review of Literature 微型正畸螺钉伪装治疗成人III类咬合不良的诊断和治疗注意事项——文献综述
Pub Date : 2019-12-20 DOI: 10.22452/ADUM.VOL26NO9
V. Bhaskar
Class III malocclusions pose a challenge to the orthodontist, and conventional treatment options to treat this condition in an adult patient include orthognathic surgery, or orthodontic camouflage. Up until a few years ago, orthodontic camouflage for correction of a Class III problem involved retroclination of the lower anterior teeth and proclination of the upper anterior teeth. The advent of skeletal anchorage systems has opened up new vistas in camouflaging Class III malocclusion due to mandibular prognathism. This article reviews the various treatment planning considerations, both clinical and radiographic, for camouflage of Class III malocclusion by miniscrew assisted distalization of the mandibular dentition, and also discusses treatment options, procedures, biomechanics and possible pitfalls.
III类错牙合对正畸医生来说是一个挑战,治疗成年患者这种情况的传统治疗方案包括正颌手术或正畸伪装。直到几年前,矫正III类问题的正畸伪装还涉及下前牙的后倾和上前牙的内旋。骨骼锚固系统的出现为掩盖下颌前突引起的III类错牙合开辟了新的前景。本文综述了通过微型螺钉辅助下颌齿列远端化来掩饰III类错牙合的各种治疗计划考虑因素,包括临床和放射学,并讨论了治疗方案、程序、生物力学和可能的陷阱。
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引用次数: 2
The New 2017 Classification of Periodontal and Peri-Implant Diseases: A Malaysian PerioSymposium 新的2017牙周和种植体周围疾病分类:马来西亚牙周研讨会
Pub Date : 2019-12-17 DOI: 10.22452/ADUM.VOL26NO8
D. Matthews, B. Thomas, Bennete Fernandes, R. Bapat, T. Chaubal, P. S. Jacob
The introduction of the recent 2017 classification of periodontal diseases has been welcomed by the periodontal fraternity. The new classification has used available evidence as the backbone for its development. It has been felt by many experts that a good understanding is required for its practice. Towards this, a Malaysian PerioSymposium was organised in May 2019 to comprehend the classification and also to identify the right path towards its learning among undergraduate students of dentistry in Malaysia. The symposium was conducted and moderated by local and international experts. Apart from the few limitations identified, the new classification was recommended to be taught in the undergraduate dental programme across schools in Malaysia.
最近2017年牙周病分类的引入受到了牙周协会的欢迎。新的分类利用了现有的证据作为其发展的支柱。许多专家认为,需要对其做法有充分的了解。为此,2019年5月组织了一次马来西亚PerioSymposium,以了解分类,并在马来西亚牙科本科生中确定正确的学习道路。研讨会由当地和国际专家主持。除了确定的少数限制外,建议在马来西亚各学校的牙科本科生课程中教授新分类。
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引用次数: 0
Multidisciplinary Management of Desquamative Gingivitis with Periodontal Disease 牙周病脱屑性牙龈炎的多学科治疗
Pub Date : 2019-08-28 DOI: 10.22452/ADUM.VOL26NO5
C. W. Cheah, R. Vaithilingam, N. Mohammad, C. Siar
Oral lichen planus is a disorder that affects the oral mucosal. Desquamative gingivitis (DG) is usually a manifestation of oral lichen planus (OLP) and may be the only clinical presentation of these disorders. There is erosion of the superficial epithelium layer. Such lesions impede proper oral hygiene indirectly increase the long-term risk for plaque-induced periodontal disease via plaque accumulation. This case report presents a multidisciplinary management of an Indian male, who suffer from OLP related desquamative gingivitis with the diagnosis of generalized chronic periodontitis. The patient was jointly managed by oral medicine specialist, periodontist and prosthodontist. Proper mangement and long term maintenance can significantly reduce the morbidity in patients associated with these conditions.
口腔扁平苔藓是一种影响口腔粘膜的疾病。脱屑性牙龈炎(DG)通常是口腔扁平苔藓(OLP)的一种表现,可能是这些疾病的唯一临床表现。浅表上皮层有糜烂。这些损害妨碍了适当的口腔卫生,通过菌斑积聚间接增加了患牙菌斑引起的牙周病的长期风险。本病例报告提出了一个多学科管理的印度男性,谁遭受OLP相关的脱屑性牙龈炎与全身性慢性牙周炎的诊断。患者由口腔医学专科医生、牙周病专科医生及口腔修复专科医生联合诊治。适当的管理和长期的维护可以显著降低与这些疾病相关的患者的发病率。
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引用次数: 1
Correction of Class II Malocclusion in a Late Adolescent Patient with ForsusTM (FRD) Appliance 使用ForsusTM(FRD)矫治器矫正一名青少年晚期患者的II类咬合不良
Pub Date : 2019-04-04 DOI: 10.22452/adum.vol26no6
Dr Mohd Zambri Mohamed Makhbul, W. N. W. Hassan
Fixed functional appliances are non-compliance dependent devices, which can assist the correction of Class II malocclusion. The mechanics of the fixed functional appliances may vary depending on the type of device used. We report the observed biomechanical effects of using the ForsusTM Fatigue Resistant Device (FRD) fixed functional appliance. The patient was a 14-year-old female presented with a Class II division I malocclusion on a Class II skeletal base. The malocclusion was complicated by a 10mm overjet and increased traumatic overbite. She was treated with the ForsusTM FRD appliance worn for 5 months after the alignment with fixed appliances (0.022” X0.028” MBT prescriptions) and finished on a non-extraction base. Dento-alveolar changes were the main contribution to the correction of the malocclusion and simultaneously improved the patient’s profile in the end of treatment. In conclusion, ForsusTM FRD appliance can be suggested to effectively correct Class II malocclusion.
固定功能矫治器是非依从性的设备,可以帮助矫正II类错牙合。固定功能器具的机械结构可能因所用设备的类型而异。我们报告了使用ForsusTM抗疲劳装置(FRD)固定功能矫治器观察到的生物力学效果。患者是一名14岁的女性,在II级骨骼基底上出现II级I类错牙合。错牙合因10mm的覆盖层和增加的外伤性覆牙而变得复杂。在与固定矫治器对齐后,她使用ForsusTM FRD矫治器进行了5个月的治疗(0.022“X0.028”MBT处方),并在非提取基础上完成。牙-牙槽的改变是矫正错牙合的主要贡献,同时在治疗结束时改善了患者的状况。总之,ForsusTM FRD矫治器可以有效地矫正II类错牙合。
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引用次数: 0
Anticariogenic properties of Solanum ferox L. ethanol extract 龙葵乙醇提取物的抗癌特性
Pub Date : 2019-04-04 DOI: 10.22452/ADUM.VOL26NO4
S. Z. Raduan, Khairah Nasrin Abdul Khalid, Mark Fitchell Ak Jihek, Sivagami Ganasan, Umi Syazana Salim, M. Aziz
Solanum ferox L. is a plant species which belongs to the Sola-naceae family and the genus Solanum. The Solanum genus was found to exhibit anticariogenic activity and was tradition-ally used to treat oral diseases. However there are no scien-tific studies done specifically for Solanum ferox L. Hence the aim of the study is to determine the anticariogenic properties of flesh and leaf of ethanolic extract of Solanum ferox L. Alka-loids, flavonoids and tannins were detected in the leaf etha-nolic extract via preliminary phytochemical screening. The presence of these phytochemicals may contribute to the anticariogenic activity. Treatment with different concentra-tions of flesh and leaf of ethanolic extract were used against Streptococcus pyogenes and Staphylococcus aureus via the method of agar well diffusion to indicate zones of inhibition. The antibiofilm activity of the flesh and leaf ethanolic extracts was tested. The flesh and leaf ethanolic extracts possess sig-nificant (p<0.05) dose-dependent on antimicrobial activity and positive antibiofilm activity against respective pathogens. Flesh ethanolic extract has stronger anticariogenic activity compared to leaf ethanolic extract against Staphylococcus aureus. Streptococcus pyogenes exhibited higher susceptibil-ity as compared to Staphylococcus aureus. In conclusion, it has been shown that the ethanolic extract of Solanum ferox L. exhibit anticariogenic properties against Streptococus py-ogenes and Staphylococcus aureus
龙葵(Solanum ferox L.)是龙葵科龙葵属植物。人们发现茄属植物具有抗致癌活性,传统上用于治疗口腔疾病。然而,目前还没有专门针对龙葵的科学研究。因此,本研究的目的是确定龙葵乙醇提取物的肉和叶的抗癌特性。通过初步的植物化学筛选,在龙葵叶片的乙醇提取物中检测到类碱、类黄酮和单宁。这些植物化学物质的存在可能有助于抗肿瘤活性。采用琼脂孔扩散法,用不同浓度的乙醇提取物对化脓性链球菌和金黄色葡萄球菌进行抑菌,确定抑菌区。测定了其肉和叶乙醇提取物的抗膜活性。肉和叶乙醇提取物具有显著(p<0.05)剂量依赖性的抗菌活性和对各自病原体的阳性抗菌膜活性。果肉乙醇提取物对金黄色葡萄球菌的抑癌活性较叶片乙醇提取物强。与金黄色葡萄球菌相比,化脓性链球菌表现出更高的敏感性。综上所述,龙葵醇提物具有抗致病性链球菌和金黄色葡萄球菌的作用
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引用次数: 2
An approach to risk isolation for relatively low-incidence conditions: An Australian national model of oral cellulitis. 一种针对相对低发病率疾病的风险隔离方法:一种澳大利亚国家口腔蜂窝组织炎模型。
Pub Date : 2019-04-04 DOI: 10.22452/ADUM.VOL26NO3
A. Anjrini, M. Tennant, E. Kruger
Aim:The purpose of this study was todevelop a risk indicator applicable on a national level, to isolate at relatively high-resolution, regions where oral cellulitis risk is high. Method:The method used ten years of Western Australian (1999 to 2008) hospitalisation data, and applying the admission risks gleaned from this database (poverty, socioeconomics, age and Indigenous status) to model across Australia (at SA1 level) the risk profile. Five levels of oral cellulitis risk (low to very high) were mapped to each of the 54,000 SA1s that makeup Australia.Cumulative percentage analysis was used to study the effect of distance from capital city of each state on the number of population at high risk. Results:Highest risk category (category 5) SA1s were not equally distributed amongst States, with the Northern Territory having 12.2% of its population (26011) belonging to category 5 (very high risk). The majority of that population (87.8%) live more than 100km away from the capital city, Darwin.A general trend amongst Australian capital cities was the low number of population at high risk within 5 km from General Post Office (GPO).
目的:本研究的目的是建立一个适用于全国水平的风险指标,以相对高分辨率分离口腔蜂窝织炎风险高的地区。方法:该方法使用西澳大利亚州(1999年至2008年)十年的住院数据,并应用从该数据库收集的入院风险(贫困、社会经济、年龄和土著身份)来模拟整个澳大利亚(SA1级)的风险概况。口腔蜂窝织炎的风险分为五个级别(低到非常高),分别对应构成澳大利亚的54,000个sa15。采用累积百分比分析法,研究各州离首府城市的距离对高危人群数量的影响。结果:最高风险类别(第5类)sa15在各州之间分布不均,北领地有12.2%的人口(26011人)属于第5类(非常高风险)。其中大多数人口(87.8%)居住在距离首府达尔文100多公里的地方。澳大利亚首都城市的总体趋势是,邮政总局(GPO) 5公里范围内的高风险人口数量较少。
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引用次数: 0
Medical emergencies in Dentistry: Practical tips in Implementation 牙科医疗紧急情况:实施中的实用技巧
Pub Date : 2019-04-04 DOI: 10.22452/adum.vol26no7
Yong Weng, R. C. Wong
In a rapidly aging society, many patients will have multiple medical co-morbidities and on polypharmacy. Dental patients rarely have medical emergencies during their treatment and it is because of this rarity, that the odd emergency that presents can overwhelm the dentist’s ability to cope despite their theoretical knowledge. The authors discuss how to adapt the clinic facilities for managing an emergency and provide an overview of management of common emergencies that dentists may encounter.
在一个快速老龄化的社会,许多患者将有多种医疗合并症和多种药物。牙科患者在治疗过程中很少遇到医疗紧急情况,正因为这种罕见,出现的奇怪紧急情况可能会压倒牙医的处理能力,尽管他们有理论知识。作者讨论了如何适应管理紧急情况的诊所设施,并提供牙医可能遇到的常见紧急情况的管理概述。
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引用次数: 1
期刊
Annals of dentistry
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