Though women are usually targeted for contraception use, fertility decisions are mostly taken by the man, who is more likely to have more children in many developing countries. This study, therefore, aimed to assess and compare fertility intentions among men in rural and urban areas of Osun State, Nigeria. This comparative cross-sectional study was conducted among 400 men in rural and urban areas of Osun State. Data collection was done using semi-structured interviewer-administered questionnaires. The mean age of the rural respondents was 40.35 ± 9.137 years, while that of the urban respondents was 42.62 ± 9.130 years (t= -3.526, P= < 0.001). Age (AOR = 2.589, 95% C.I = 1.476 - 4.540), education (AOR = 0.478, 95% C.I = 0.287 -0.797), religion (AOR = 2.671, 95% C.I = 1.694 - 4.214) and number of living children (AOR = 2.411, 95% C.I = 1.381 - 4.211) predicted fertility intentions in the urban areas.
虽然妇女通常是避孕的目标,但生育的决定主要是由男性做出的,在许多发展中国家,男性更有可能生育更多的孩子。因此,这项研究旨在评估和比较尼日利亚奥松州农村和城市地区男性的生育意愿。这项比较横断面研究在奥松州农村和城市地区的400名男子中进行。数据收集采用半结构化的访谈者管理问卷。农村被调查者的平均年龄为40.35±9.137岁,城市被调查者的平均年龄为42.62±9.130岁(t= -3.526, P= < 0.001)。年龄(AOR = 2.589, 95% ci = 1.476 ~ 4.540)、教育程度(AOR = 0.478, 95% ci = 0.287 ~ 0.797)、宗教信仰(AOR = 2.671, 95% ci = 1.694 ~ 4.214)和在生子女数(AOR = 2.411, 95% ci = 1.381 ~ 4.211)对城市地区生育意愿有预测作用。
{"title":"Fertility intentions among men in rural and urban communities in Osun State, Nigeria- A comparative study.","authors":"Kolawole Sodeinde, Kofoworola Odeyemi, Sonnen Atinge, Oluwafunmilola Biobaku, Ngozi Adefala, Adebola Omotosho, Abiodun Osinaike, Aderinsola Faturoti, Damilotun Awoyale, Judith Ikpeazu","doi":"10.29063/ajrh2025/v29i10.18","DOIUrl":"10.29063/ajrh2025/v29i10.18","url":null,"abstract":"<p><p>Though women are usually targeted for contraception use, fertility decisions are mostly taken by the man, who is more likely to have more children in many developing countries. This study, therefore, aimed to assess and compare fertility intentions among men in rural and urban areas of Osun State, Nigeria. This comparative cross-sectional study was conducted among 400 men in rural and urban areas of Osun State. Data collection was done using semi-structured interviewer-administered questionnaires. The mean age of the rural respondents was 40.35 ± 9.137 years, while that of the urban respondents was 42.62 ± 9.130 years (t= -3.526, P= < 0.001). Age (AOR = 2.589, 95% C.I = 1.476 - 4.540), education (AOR = 0.478, 95% C.I = 0.287 -0.797), religion (AOR = 2.671, 95% C.I = 1.694 - 4.214) and number of living children (AOR = 2.411, 95% C.I = 1.381 - 4.211) predicted fertility intentions in the urban areas.</p>","PeriodicalId":7551,"journal":{"name":"African journal of reproductive health","volume":"29 10","pages":"176-186"},"PeriodicalIF":1.0,"publicationDate":"2025-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145480642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-30DOI: 10.29063/ajrh2025/v29i10.1
Cecilia Maurente Beherns, Lindsay Edouard
Shifting geopolitical policies, competing priorities and declines in national economies have lately led to a decrease in foreign aid from various donor countries with implications for multilateral agencies. This sharp fall in official development assistance threatens the attainment of sustainable development goals, especially as pertaining to sexual and reproductive health and rights across the global south. International concerns have led to calls for innovative partnerships, alternative resource mobilisation, and stronger community engagement. This challenge offers opportunities for both governments and civil society to shift from dependency to sustainability through alternative pathways for domestic resource mobilisation and much more predictable financing.
{"title":"Official development assistance: from dependency to sustainability.","authors":"Cecilia Maurente Beherns, Lindsay Edouard","doi":"10.29063/ajrh2025/v29i10.1","DOIUrl":"https://doi.org/10.29063/ajrh2025/v29i10.1","url":null,"abstract":"<p><p>Shifting geopolitical policies, competing priorities and declines in national economies have lately led to a decrease in foreign aid from various donor countries with implications for multilateral agencies. This sharp fall in official development assistance threatens the attainment of sustainable development goals, especially as pertaining to sexual and reproductive health and rights across the global south. International concerns have led to calls for innovative partnerships, alternative resource mobilisation, and stronger community engagement. This challenge offers opportunities for both governments and civil society to shift from dependency to sustainability through alternative pathways for domestic resource mobilisation and much more predictable financing.</p>","PeriodicalId":7551,"journal":{"name":"African journal of reproductive health","volume":"29 10","pages":"11-17"},"PeriodicalIF":1.0,"publicationDate":"2025-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145429871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
This study aimed to explore the effect of the discharge readiness linkage intervention programme based on the Meleis transformation theory in the home ward of preterm infants. The study population consisted of 74 preterm infants and their caregivers who were admitted to the NICU of Chifeng Municipal Hospital between January and June 2023. The intervention group received the routine care combined with the intervention model of discharge preparation based on the Meleis transition theory, while the control group received routine care. The results indicated that the discharge readiness linkage intervention programme based on the Meleis transformation theory significantly improved the caregiving capacity of preterm caregivers, increased the readiness of the babies for discharge, and reduced the readmission rate of preterm infants within 1 year of discharge. In addition, the discharge readiness linkage intervention programme based on the Meleis transformation theory helped to improve the physical development of preterm babies and the negative emotions of caregivers. We conclude that the discharge readiness linkage intervention programme based on the Meleis transformation theory effectively improves the survival of preterm infants.
{"title":"Impact of a nursing intervention based on Meleis transformation theory on discharge readiness of preterm infants: an intervention study.","authors":"Baoyu Li, Mengnan Li, Liyuan Tian, Hongjuan Pang, Songyan Zhao","doi":"10.29063/ajrh2025/v29i10.4","DOIUrl":"https://doi.org/10.29063/ajrh2025/v29i10.4","url":null,"abstract":"<p><p>This study aimed to explore the effect of the discharge readiness linkage intervention programme based on the Meleis transformation theory in the home ward of preterm infants. The study population consisted of 74 preterm infants and their caregivers who were admitted to the NICU of Chifeng Municipal Hospital between January and June 2023. The intervention group received the routine care combined with the intervention model of discharge preparation based on the Meleis transition theory, while the control group received routine care. The results indicated that the discharge readiness linkage intervention programme based on the Meleis transformation theory significantly improved the caregiving capacity of preterm caregivers, increased the readiness of the babies for discharge, and reduced the readmission rate of preterm infants within 1 year of discharge. In addition, the discharge readiness linkage intervention programme based on the Meleis transformation theory helped to improve the physical development of preterm babies and the negative emotions of caregivers. We conclude that the discharge readiness linkage intervention programme based on the Meleis transformation theory effectively improves the survival of preterm infants.</p>","PeriodicalId":7551,"journal":{"name":"African journal of reproductive health","volume":"29 10","pages":"40-49"},"PeriodicalIF":1.0,"publicationDate":"2025-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145436886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
This study aimed to develop a magnetic resonance imaging (MRI) and clinical factor-based nomogram for prenatal diagnosis of placenta accreta spectrum disorders (PAS). Clinical and MRI data from pregnant women were retrospectively analyzed and split into training (70%) and validation (30%) sets. Binary logistic regression identified age, placenta previa, T2 dark band, placental/uterine bulge, loss of T2 hypointense interface, myometrial thinning, and abnormal placental bed vessels as significant predictors of PAS. A nomogram incorporating these factors demonstrated strong diagnostic performance via ROC analysis (AUC >0.8), calibration curves, and decision curve analysis (DCA) in both training and validation sets. The model showed high accuracy and clinical utility, supporting its use in prenatal PAS diagnosis.
{"title":"Nomogram model based on magnetic resonance imaging and clinical factors for prenatal diagnosis of placenta accreta spectrum disorders.","authors":"Jingjing Zhong, Qin Zhang, Peipei Lin, Dandan Miao, Honggang Yin","doi":"10.29063/ajrh2025/v29i10.16","DOIUrl":"10.29063/ajrh2025/v29i10.16","url":null,"abstract":"<p><p>This study aimed to develop a magnetic resonance imaging (MRI) and clinical factor-based nomogram for prenatal diagnosis of placenta accreta spectrum disorders (PAS). Clinical and MRI data from pregnant women were retrospectively analyzed and split into training (70%) and validation (30%) sets. Binary logistic regression identified age, placenta previa, T2 dark band, placental/uterine bulge, loss of T2 hypointense interface, myometrial thinning, and abnormal placental bed vessels as significant predictors of PAS. A nomogram incorporating these factors demonstrated strong diagnostic performance via ROC analysis (AUC >0.8), calibration curves, and decision curve analysis (DCA) in both training and validation sets. The model showed high accuracy and clinical utility, supporting its use in prenatal PAS diagnosis.</p>","PeriodicalId":7551,"journal":{"name":"African journal of reproductive health","volume":"29 10","pages":"155-166"},"PeriodicalIF":1.0,"publicationDate":"2025-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145480661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-30DOI: 10.29063/ajrh2025/v29i10.12
Xiaorong Qiu, Shuang Lin, Hao Pan, Yingnan Wang, Sining Ma
Training competent clinicians in reproductive health requires teaching approaches that integrate theoretical knowledge with clinical reasoning, communication, and evidence-based decision-making. Traditional lecture-based methods often fall short of addressing this complex need in obstetrics and gynecology education. This study examined the effectiveness of an integrated teaching model that combines Case-Based Learning (CBL), Problem-Based Learning (PBL), Standardized Patients (SP), and Evidence-Based Medicine (EBM) in improving clinical competence, critical thinking, and evidence-based application. A prospective, quasi experimental study was conducted in January and June 2024 at Zhongshan Hospital Fudan University, involving 100 medical interns during their rotation in obstetrics and gynecology. Participants were randomly assigned to an integrated teaching group or a control group receiving conventional lectures. Post-intervention results showed that the integrated group scored significantly higher in clinical performance (Mini-CEX: 8.3 ± 0.9 vs. 6.8 ± 1.1), critical thinking (CTSI: 180.3 ± 15.2 vs. 134.1 ± 14.3), EBM competency (26.9 ± 2.3 vs. 22.9 ± 2.5), and teaching satisfaction (95.2% vs. 75.3%) (all p < 0.01). These findings suggest that the combined CBL/PBL/SP/EBM model effectively enhances clinical and analytical capabilities in reproductive health training. Its broader application could improve the quality of obstetrics and gynecology education and better prepare future healthcare professionals.
{"title":"Enhancing reproductive health clinical training through integrated pedagogy: A quasi-experimental study.","authors":"Xiaorong Qiu, Shuang Lin, Hao Pan, Yingnan Wang, Sining Ma","doi":"10.29063/ajrh2025/v29i10.12","DOIUrl":"10.29063/ajrh2025/v29i10.12","url":null,"abstract":"<p><p>Training competent clinicians in reproductive health requires teaching approaches that integrate theoretical knowledge with clinical reasoning, communication, and evidence-based decision-making. Traditional lecture-based methods often fall short of addressing this complex need in obstetrics and gynecology education. This study examined the effectiveness of an integrated teaching model that combines Case-Based Learning (CBL), Problem-Based Learning (PBL), Standardized Patients (SP), and Evidence-Based Medicine (EBM) in improving clinical competence, critical thinking, and evidence-based application. A prospective, quasi experimental study was conducted in January and June 2024 at Zhongshan Hospital Fudan University, involving 100 medical interns during their rotation in obstetrics and gynecology. Participants were randomly assigned to an integrated teaching group or a control group receiving conventional lectures. Post-intervention results showed that the integrated group scored significantly higher in clinical performance (Mini-CEX: 8.3 ± 0.9 vs. 6.8 ± 1.1), critical thinking (CTSI: 180.3 ± 15.2 vs. 134.1 ± 14.3), EBM competency (26.9 ± 2.3 vs. 22.9 ± 2.5), and teaching satisfaction (95.2% vs. 75.3%) (all p < 0.01). These findings suggest that the combined CBL/PBL/SP/EBM model effectively enhances clinical and analytical capabilities in reproductive health training. Its broader application could improve the quality of obstetrics and gynecology education and better prepare future healthcare professionals.</p>","PeriodicalId":7551,"journal":{"name":"African journal of reproductive health","volume":"29 10","pages":"118-124"},"PeriodicalIF":1.0,"publicationDate":"2025-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145480678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-30DOI: 10.29063/ajrh2025/v29i10.8
Li Wang, Yuanyuan Liu, Shuangshuang Li
The objective of the study was to investigate the effectiveness of cluster nursing intervention in preventing urinary catheter-related urinary tract infections. Seventy-eight patients with indwelling urethral catheters admitted to Funan County Hospital of Traditional Chinese Medicine from January 2020 to December 2020 were recruited as study participants. They were randomly divided into a control group (routine nursing intervention) and an observation group (cluster nursing intervention). The results showed that compared with the control group, the observation group had better total effectiveness rate, shorter indwelling catheter time, shorter disappearance time of bladder irritation symptoms, higher scores of emotional role, physical health, cognitive ability, social function and quality of life, lower occurrence of adverse catheter events, and higher nursing satisfaction. We conclude that clustered nursing can reduce the occurrence of urinary catheter-related urinary tract infections, promote the quality of life, shorten the duration of catheter indwelling and bladder irritation symptoms, prevent adverse catheter events, and improve nursing satisfaction of patients with patients with indwelling urinary catheters.
{"title":"Effectiveness of cluster nursing intervention in preventing urinary catheter-related urinary tract infections.","authors":"Li Wang, Yuanyuan Liu, Shuangshuang Li","doi":"10.29063/ajrh2025/v29i10.8","DOIUrl":"10.29063/ajrh2025/v29i10.8","url":null,"abstract":"<p><p>The objective of the study was to investigate the effectiveness of cluster nursing intervention in preventing urinary catheter-related urinary tract infections. Seventy-eight patients with indwelling urethral catheters admitted to Funan County Hospital of Traditional Chinese Medicine from January 2020 to December 2020 were recruited as study participants. They were randomly divided into a control group (routine nursing intervention) and an observation group (cluster nursing intervention). The results showed that compared with the control group, the observation group had better total effectiveness rate, shorter indwelling catheter time, shorter disappearance time of bladder irritation symptoms, higher scores of emotional role, physical health, cognitive ability, social function and quality of life, lower occurrence of adverse catheter events, and higher nursing satisfaction. We conclude that clustered nursing can reduce the occurrence of urinary catheter-related urinary tract infections, promote the quality of life, shorten the duration of catheter indwelling and bladder irritation symptoms, prevent adverse catheter events, and improve nursing satisfaction of patients with patients with indwelling urinary catheters.</p>","PeriodicalId":7551,"journal":{"name":"African journal of reproductive health","volume":"29 10","pages":"83-89"},"PeriodicalIF":1.0,"publicationDate":"2025-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145480609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-30DOI: 10.29063/ajrh2025/v29i10.19
Özlem Koç, Tuğçe Sönmez, Tural Ismayilov
During pregnancy, various factors influence sexual life, and religious attitudes play a significant role. However, studies on sexual satisfaction and religious attitudes in pregnant Muslim women are limited. This cross-sectional study, conducted in Türkiye's Mediterranean region with 230 pregnant volunteers (October 2023-March 2024), found that sexual satisfaction is significantly associated with educational status, frequency of intercourse, perceptions of safety, and feelings of shame or guilt. Despite no restrictions on sexual activity in healthy pregnancies, religious beliefs can negatively impact sexual life. The study highlights the lack of discussion on female sexuality during pregnancy in clinical settings and emphasizes the need for integrating this topic into pregnancy education. While contributing to the limited literature, findings are specific to one region and based on self-reported data, which may introduce bias.
{"title":"Relationship between sexual satisfaction and religious attitudes in pregnant Muslim women: A cross-sectional study in Türkiye.","authors":"Özlem Koç, Tuğçe Sönmez, Tural Ismayilov","doi":"10.29063/ajrh2025/v29i10.19","DOIUrl":"10.29063/ajrh2025/v29i10.19","url":null,"abstract":"<p><p>During pregnancy, various factors influence sexual life, and religious attitudes play a significant role. However, studies on sexual satisfaction and religious attitudes in pregnant Muslim women are limited. This cross-sectional study, conducted in Türkiye's Mediterranean region with 230 pregnant volunteers (October 2023-March 2024), found that sexual satisfaction is significantly associated with educational status, frequency of intercourse, perceptions of safety, and feelings of shame or guilt. Despite no restrictions on sexual activity in healthy pregnancies, religious beliefs can negatively impact sexual life. The study highlights the lack of discussion on female sexuality during pregnancy in clinical settings and emphasizes the need for integrating this topic into pregnancy education. While contributing to the limited literature, findings are specific to one region and based on self-reported data, which may introduce bias.</p>","PeriodicalId":7551,"journal":{"name":"African journal of reproductive health","volume":"29 10","pages":"187-194"},"PeriodicalIF":1.0,"publicationDate":"2025-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145480698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-30DOI: 10.29063/ajrh2025/v29i10.10
Dan Yang, Taoran Mo, Qian Chen, Lei Liang
This was an original study, aimed to explore the efficacy of rapid urease, serum antibody and histopathological detection of Helicobacter pylori (Hp) infection in children. One hundred and forty (140)children admitted to Liaoning Cancer Hospital & Institute due to gastrointestinal symptoms who underwent electronic gastroscopy from June 2020 to June 2022 were included. Among the 140 children, 72 were positive for Hp infection by rapid urease, 71 with serum antibody, and 67 with histopathology. The specificities of Hp infection detected by the three methods - rapid urease, serum antibody and histology were 88.7%, 90.6% and 91.7%, respectively. We conclude that the combination of three detection methods of rapid urease, serum antibody and histopathology can improve the sensitivity, specificity, and the accuracy of Hp detection.
{"title":"Effectiveness of rapid urease, serum antibody, and histopathological detection of helicobacter pylori infection in children.","authors":"Dan Yang, Taoran Mo, Qian Chen, Lei Liang","doi":"10.29063/ajrh2025/v29i10.10","DOIUrl":"10.29063/ajrh2025/v29i10.10","url":null,"abstract":"<p><p>This was an original study, aimed to explore the efficacy of rapid urease, serum antibody and histopathological detection of Helicobacter pylori (Hp) infection in children. One hundred and forty (140)children admitted to Liaoning Cancer Hospital & Institute due to gastrointestinal symptoms who underwent electronic gastroscopy from June 2020 to June 2022 were included. Among the 140 children, 72 were positive for Hp infection by rapid urease, 71 with serum antibody, and 67 with histopathology. The specificities of Hp infection detected by the three methods - rapid urease, serum antibody and histology were 88.7%, 90.6% and 91.7%, respectively. We conclude that the combination of three detection methods of rapid urease, serum antibody and histopathology can improve the sensitivity, specificity, and the accuracy of Hp detection.</p>","PeriodicalId":7551,"journal":{"name":"African journal of reproductive health","volume":"29 10","pages":"100-108"},"PeriodicalIF":1.0,"publicationDate":"2025-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145480673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-30DOI: 10.29063/ajrh2025/v29i10.3
Doriah Abilash, Tb Sridharan
Semen cryopreservation is an essential technique in artificial insemination (AI) and assisted reproductive technology (ART). The addition of antioxidants to the freezing medium is a promising strategy to reduce cryo-induced damage to sperm cells. While sperm freezing has been extensively studied, this research aimed to improve the post-thaw durability and functionality of sperm. A total of 110 semen samples 55 from fertile and 55 from infertile individuals were collected and processed. After centrifugation, each sample was mixed with a cryoprotectant medium at a 1:1 (v/v) ratio. Three different cryoprotectant formulations (S1, S2, and S3), each containing varying concentrations of protective agents, were evaluated. The samples were then frozen in liquid nitrogen at -196°C. Post-thaw analyses included assessments of sperm count, motility, vitality, morphology, DNA fragmentation, and reactive oxygen species (ROS) levels representing a major strength of the study due to the comprehensive evaluation of sperm quality. The results showed significant differences in DNA fragmentation between fresh and cryopreserved samples. Among the tested formulations, S3 supplemented with citric acid anhydrous and taurine produced the best outcomes. It significantly improved sperm motility and vitality, while effectively reducing oxidative stress and cryodamage. Statistical analysis using one-way ANOVA and Tukey's HSD test revealed significant differences in sperm morphology between fresh and post-thaw S3-treated samples (p < 0.05), with a 95% confidence level. A limitation of the study was the long interval between the use of fresh control samples and the analysis of cryopreserved samples, which may influence comparative accuracy. Despite this limitation, the findings suggest that the S3 formulation is highly effective in preserving sperm quality. These results support its potential integration into fertility preservation protocols in ART. Furthermore, the outcomes may guide clinical practice and support the development of national policies aimed at improving access to advanced cryopreservation techniques as part of comprehensive reproductive healthcare services.
{"title":"A Study of the durability of sperm cell motility and deoxyribo-nucleic acid damage during cryopreservation.","authors":"Doriah Abilash, Tb Sridharan","doi":"10.29063/ajrh2025/v29i10.3","DOIUrl":"https://doi.org/10.29063/ajrh2025/v29i10.3","url":null,"abstract":"<p><p>Semen cryopreservation is an essential technique in artificial insemination (AI) and assisted reproductive technology (ART). The addition of antioxidants to the freezing medium is a promising strategy to reduce cryo-induced damage to sperm cells. While sperm freezing has been extensively studied, this research aimed to improve the post-thaw durability and functionality of sperm. A total of 110 semen samples 55 from fertile and 55 from infertile individuals were collected and processed. After centrifugation, each sample was mixed with a cryoprotectant medium at a 1:1 (v/v) ratio. Three different cryoprotectant formulations (S1, S2, and S3), each containing varying concentrations of protective agents, were evaluated. The samples were then frozen in liquid nitrogen at -196°C. Post-thaw analyses included assessments of sperm count, motility, vitality, morphology, DNA fragmentation, and reactive oxygen species (ROS) levels representing a major strength of the study due to the comprehensive evaluation of sperm quality. The results showed significant differences in DNA fragmentation between fresh and cryopreserved samples. Among the tested formulations, S3 supplemented with citric acid anhydrous and taurine produced the best outcomes. It significantly improved sperm motility and vitality, while effectively reducing oxidative stress and cryodamage. Statistical analysis using one-way ANOVA and Tukey's HSD test revealed significant differences in sperm morphology between fresh and post-thaw S3-treated samples (p < 0.05), with a 95% confidence level. A limitation of the study was the long interval between the use of fresh control samples and the analysis of cryopreserved samples, which may influence comparative accuracy. Despite this limitation, the findings suggest that the S3 formulation is highly effective in preserving sperm quality. These results support its potential integration into fertility preservation protocols in ART. Furthermore, the outcomes may guide clinical practice and support the development of national policies aimed at improving access to advanced cryopreservation techniques as part of comprehensive reproductive healthcare services.</p>","PeriodicalId":7551,"journal":{"name":"African journal of reproductive health","volume":"29 10","pages":"30-39"},"PeriodicalIF":1.0,"publicationDate":"2025-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145436923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-30DOI: 10.29063/ajrh2025/v29i10.21
Amani A Mohammed, Zahara H Hazazi, Bandar N Alhumaidi, Shadaid Alanezi, Fares Alshammari, Alanoud Alobaidly, Daniel M Mamanao, Amal Zaman, Manal H Suliman, Afaf Aa Abdalla, Nagat Sy Eltaher, Warda E Hamed, Amani Ae Taha, Ghadeer Am Sharawi, Veerabhadra Swamy, Hammad A Fadlalmola
Labor pain is often managed with pharmacological interventions, which can lead to several adverse effects for mothers and neonates. Consequently, non-pharmacological interventions are gaining attention as safer alternatives for pain relief during labor. This systematic review aimed to assess the effectiveness of non-pharmacological methods in reducing labor pain. A comprehensive search was conducted in PubMed, Scopus, Web of Science, and Cochrane Library databases up to September 2024. Only randomized controlled trials (RCTs) evaluating non-pharmacological interventions for labor pain relief were included, with pain intensity during cervical dilatation as the primary outcome. Data synthesis was performed using RevMan (V5.3). Seventy-seven RCTs involving 8,805 pregnant women were analyzed. The results indicated that non-pharmacological methods significantly reduced pain at 3-4 cm cervical dilatation compared to control groups (M.D. = -1.63, 95% C.I. [-2.05 to -1.21], P < 0.0001). Notably, subgroup analysis showed that body acupressure (M.D. = -2.08, 95% C.I. [-2.76 to -1.40], P < 0.0001) and foot reflexology (M.D. = -2.48, 95% C.I. [-2.84 to -2.13], P < 0.0001) were particularly effective. High heterogeneity (I² > 90%) was noted, partly reflecting differences in intervention types, protocols, and participant characteristics. Overall, non-pharmacological interventions provided substantial relief in labor pain compared to standard care, suggesting their potential utility in obstetric practice. Further large-scale studies are warranted to confirm these findings.
分娩疼痛通常通过药物干预来处理,这可能会对母亲和新生儿产生一些不良影响。因此,非药物干预作为分娩过程中缓解疼痛的更安全的选择而受到关注。本系统综述旨在评估非药物方法在减轻分娩疼痛方面的有效性。在PubMed, Scopus, Web of Science和Cochrane Library数据库中进行了全面的搜索,截止到2024年9月。仅纳入评估非药物干预措施缓解分娩疼痛的随机对照试验(rct),以宫颈扩张期间的疼痛强度为主要结局。使用RevMan (V5.3)软件进行数据综合。共分析了77项随机对照试验,涉及8805名孕妇。结果表明,与对照组相比,非药物方法明显减轻了3-4 cm宫颈扩张时的疼痛(M.D. = -1.63, 95% C.I. [-2.05 ~ -1.21], P < 0.0001)。值得注意的是,亚组分析显示体指压(M.D. = -2.08, 95% C.I. [-2.76 ~ -1.40], P < 0.0001)和足反射(M.D. = -2.48, 95% C.I. [-2.84 ~ -2.13], P < 0.0001)特别有效。注意到高异质性(I²> 90%),部分反映了干预类型、方案和参与者特征的差异。总的来说,与标准护理相比,非药物干预在分娩疼痛方面提供了实质性的缓解,这表明它们在产科实践中的潜在效用。需要进一步的大规模研究来证实这些发现。
{"title":"Efficacy of non-pharmacological interventions for labor pain reduction: A systematic review and meta-analysis.","authors":"Amani A Mohammed, Zahara H Hazazi, Bandar N Alhumaidi, Shadaid Alanezi, Fares Alshammari, Alanoud Alobaidly, Daniel M Mamanao, Amal Zaman, Manal H Suliman, Afaf Aa Abdalla, Nagat Sy Eltaher, Warda E Hamed, Amani Ae Taha, Ghadeer Am Sharawi, Veerabhadra Swamy, Hammad A Fadlalmola","doi":"10.29063/ajrh2025/v29i10.21","DOIUrl":"10.29063/ajrh2025/v29i10.21","url":null,"abstract":"<p><p>Labor pain is often managed with pharmacological interventions, which can lead to several adverse effects for mothers and neonates. Consequently, non-pharmacological interventions are gaining attention as safer alternatives for pain relief during labor. This systematic review aimed to assess the effectiveness of non-pharmacological methods in reducing labor pain. A comprehensive search was conducted in PubMed, Scopus, Web of Science, and Cochrane Library databases up to September 2024. Only randomized controlled trials (RCTs) evaluating non-pharmacological interventions for labor pain relief were included, with pain intensity during cervical dilatation as the primary outcome. Data synthesis was performed using RevMan (V5.3). Seventy-seven RCTs involving 8,805 pregnant women were analyzed. The results indicated that non-pharmacological methods significantly reduced pain at 3-4 cm cervical dilatation compared to control groups (M.D. = -1.63, 95% C.I. [-2.05 to -1.21], P < 0.0001). Notably, subgroup analysis showed that body acupressure (M.D. = -2.08, 95% C.I. [-2.76 to -1.40], P < 0.0001) and foot reflexology (M.D. = -2.48, 95% C.I. [-2.84 to -2.13], P < 0.0001) were particularly effective. High heterogeneity (I² > 90%) was noted, partly reflecting differences in intervention types, protocols, and participant characteristics. Overall, non-pharmacological interventions provided substantial relief in labor pain compared to standard care, suggesting their potential utility in obstetric practice. Further large-scale studies are warranted to confirm these findings.</p>","PeriodicalId":7551,"journal":{"name":"African journal of reproductive health","volume":"29 10","pages":"207-228"},"PeriodicalIF":1.0,"publicationDate":"2025-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145480693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}