American Journal of Ophthalmology最新文献

{"title":"Comment on: Potential eye disorders in people with and without Type 2 diabetes mellitus exposed to GLP-1 receptor agonists; an examination of the FAERS database","authors":"Víctor Manuel Asensio Sánchez","doi":"10.1016/j.ajo.2026.01.042","DOIUrl":"https://doi.org/10.1016/j.ajo.2026.01.042","url":null,"abstract":"","PeriodicalId":7568,"journal":{"name":"American Journal of Ophthalmology","volume":"9 1","pages":""},"PeriodicalIF":4.2,"publicationDate":"2026-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146146256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical and Multimodal Imaging Findings in Extensive Macular Atrophy with Pseudodrusen (EMAP): A Systematic Review and Meta-Analysis","authors":"Mateus Pimenta Arruda, Rian Vilar Lima, Giulia S. Del Valle, Mariana T. Zinher, Carlos Eduardo de Menezes, Souza Filho, Andres Bravo-Gonzalez, Larissa Irigoyen Teixeira Barbosa, Heitor Santos Nogueira, Valdez Melo dos Anjos Filho, Samuel Montenegro Pereira, Ricardo A. Pontes de Carvalho, Luiz H. Lima","doi":"10.1016/j.ajo.2026.02.006","DOIUrl":"https://doi.org/10.1016/j.ajo.2026.02.006","url":null,"abstract":"<ce:bold>:</ce:bold> This systematic review and meta-analysis aimed to integrate the clinical and multimodal imaging features of extensive macular atrophy associated with pseudodrusen (EMAP), and to evaluate its progression and associated risk factors.","PeriodicalId":7568,"journal":{"name":"American Journal of Ophthalmology","volume":"1 1","pages":""},"PeriodicalIF":4.2,"publicationDate":"2026-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146146421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adherence of economic evaluations of interventions for retinal conditions to CHEERS guidelines: A systematic review and critical appraisal","authors":"Jeeventh Kaur, Damanveer Bhogal, Lina Ghattas, Katie Neville, Ryan Huang, Rafael N Miranda, Tina Felfeli","doi":"10.1016/j.ajo.2026.02.008","DOIUrl":"https://doi.org/10.1016/j.ajo.2026.02.008","url":null,"abstract":"There have been rapid advancements in treatment of retinal disease, with the recent development of novel therapies for many common conditions. Economic evaluation studies are used to examine the implications of implementing health interventions. The objectives of this review were to (1) assess the reporting quality of economic evaluations on retina-related conditions, and (2) evaluate the risk of bias of identified studies, given the implications of bias on study critical appraisal.","PeriodicalId":7568,"journal":{"name":"American Journal of Ophthalmology","volume":"93 1","pages":""},"PeriodicalIF":4.2,"publicationDate":"2026-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146146261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comprehensive Ocular Characteristics in Cystinosis after Hematopoietic Stem-Cell Gene Therapy over 24 Months: Short title: Ocular Findings in Cystinosis After Stem-Cell Gene Therapy","authors":"Natalie A. Afshari, Bryanna J. Lee, Shyamanga Borooah, Eric Nudleman, Imama Ahmed, Anne Sawyers, Juan Arias, Nikki Manalang, Stephanie Cherqui","doi":"10.1016/j.ajo.2026.01.038","DOIUrl":"https://doi.org/10.1016/j.ajo.2026.01.038","url":null,"abstract":"Characterize ocular structure and function in cystinosis and describe 24-month outcomes after autologous hematopoietic stem-cell gene therapy (HSCT).","PeriodicalId":7568,"journal":{"name":"American Journal of Ophthalmology","volume":"6 1","pages":""},"PeriodicalIF":4.2,"publicationDate":"2026-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146146262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Delayed-Onset Endophthalmitis Associated with Glaucoma Drainage Implant","authors":"Charles Zhang, Georges AbouKasm, Lauren Kiryakoza, Landon J Rohowetz, Steven J Gedde, Harry W Flynn Jr","doi":"10.1016/j.ajo.2026.02.010","DOIUrl":"https://doi.org/10.1016/j.ajo.2026.02.010","url":null,"abstract":"To report the clinical presentations, microbial spectrum, management approaches and outcomes of endophthalmitis associated with glaucoma drainage implants (GDIs).","PeriodicalId":7568,"journal":{"name":"American Journal of Ophthalmology","volume":"1 1","pages":""},"PeriodicalIF":4.2,"publicationDate":"2026-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146146263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk of Dementia in Type 2 Diabetes Patients with Open-Angle Glaucoma: Insights from a Nationwide Real-World Cohort Study","authors":"Jingru Zhou, David A. Lee, Yashar Talebi, Gloria Wu, Hulin Wu","doi":"10.1016/j.ajo.2026.02.003","DOIUrl":"https://doi.org/10.1016/j.ajo.2026.02.003","url":null,"abstract":"","PeriodicalId":7568,"journal":{"name":"American Journal of Ophthalmology","volume":"23 1","pages":""},"PeriodicalIF":4.2,"publicationDate":"2026-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146138284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stromal Keratitis in the Zoster Eye Disease Study (ZEDS): Lessons Learned","authors":"Deborah S. Jacobs, TingFang Lee, Penny Asbell, Joanne Shen, Mazen Choulakian, Keith H. Baratz, Christina R. Prescott, Kathryn Colby, Judith S Hochman, Andrea B. Troxel, Elisabeth Cohen, Bennie H. Jeng, Gary N. Holland","doi":"10.1016/j.ajo.2026.01.034","DOIUrl":"https://doi.org/10.1016/j.ajo.2026.01.034","url":null,"abstract":"","PeriodicalId":7568,"journal":{"name":"American Journal of Ophthalmology","volume":"89 1","pages":""},"PeriodicalIF":4.2,"publicationDate":"2026-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146134118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Paired-Eye Analysis of Deep Anterior Lamellar Keratoplasty Versus Mushroom Penetrating Keratoplasty Over 5 Years","authors":"Luigi De Rosa, Andrea Taloni, Raphael Kilian, Georgiana Camburu, Valentino de Ruvo, Nicolò Ciarmatori, Rossella Spena, Linda Marie Louise Busin, Cristina Bovone, Angeli Christy Yu, Niccolò Salgari, Massimo Busin","doi":"10.1016/j.ajo.2026.01.039","DOIUrl":"https://doi.org/10.1016/j.ajo.2026.01.039","url":null,"abstract":"","PeriodicalId":7568,"journal":{"name":"American Journal of Ophthalmology","volume":"2 1","pages":""},"PeriodicalIF":4.2,"publicationDate":"2026-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146134117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Three-Year Outcomes of Toric vs Non-toric Monofocal Intraocular Lens Implantation in Children Aged 3-8 Years With Congenital Cataract.","authors":"Lei Cai, Runhan Shi, Xuanqiao Lin, Xiaohuan Zhao, Yanhong Hou, Xiaoyan Han, Zhixiang Hua, Wenqian Shen, Xiaodi Qiu, Jiaxu Hong, Jin Yang","doi":"10.1016/j.ajo.2026.01.041","DOIUrl":"https://doi.org/10.1016/j.ajo.2026.01.041","url":null,"abstract":"<p><strong>Objective: </strong>To compare 3-year visual outcomes of toric and non-toric intraocular lens (IOL) implantation in children aged 3-8 years with congenital cataracts and ≥2.0D corneal astigmatism.</p><p><strong>Design: </strong>Prospective, nonrandomized, comparative, single-center clinical study SUBJECTS: We enrolled children with congenital cataract who had ≥2.0D corneal astigmatism and were aged 3-8 years. Among 236 eligible patients, we included 194 who completed the 3-year follow-up.</p><p><strong>Interventions: </strong>Participants underwent toric IOL implantation (toric group) or non-toric monofocal IOL implantation (non-toric group) based on the parental preference.</p><p><strong>Main outcome measures: </strong>The primary outcome was corrected distance visual acuity (CDVA) during the 3-year follow-up period, which was measured in logMAR units.</p><p><strong>Results: </strong>Among the 194 participants (75 [38.7%] female), there were 106 and 88 patients in the non-toric and toric groups, respectively. Both groups demonstrated significant improvements in uncorrected distance visual acuity (UDVA) and CDVA at the endpoint (P < 0.001). At 3 years, the toric group had a significantly better mean CDVA than the non-toric group (P = .003). The toric group had a significantly higher proportion of eyes that achieved non-amblyopic vision (CDVA ≥0.8) than the non-toric group (86.4% vs. 69.8%, P = .009). In the subgroup analysis, among patients with preoperative corneal astigmatism >3.0 D, the toric group exhibited significantly better CDVA than the non-toric group from 3 months to 3 years postoperatively (P < 0.001). Contrastingly, among patients with astigmatism ≤3.0 D, there was no significant between-group difference in CDVA. Notably, the toric group demonstrated significantly lower postoperative refractive astigmatism than the non-toric group throughout the follow-up period (P<0.05). None of the patients rotated ≥10° or required IOL repositioning surgery.</p><p><strong>Conclusions: </strong>For children aged 3-8 years with congenital cataracts and corneal astigmatism ≥2.0 D, toric IOL implantation provided superior long-term visual outcomes and reduced amblyopia rates compared with non-toric monofocal IOL implantation. This supports its consideration as the preferred surgical approach for optimizing visual rehabilitation in this population.</p>","PeriodicalId":7568,"journal":{"name":"American Journal of Ophthalmology","volume":" ","pages":""},"PeriodicalIF":4.2,"publicationDate":"2026-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146130647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical evidence of valve-like structures in Schlemm’s canal and their anatomic links detected by optical coherence tomography","authors":"Ronald L Fellman, Steven Padilla, Avery Liu, Matthew Holliman, Chen Xin, Elizabeth Martin, Davinder Grover, Ruikang K Wang","doi":"10.1016/j.ajo.2026.01.032","DOIUrl":"https://doi.org/10.1016/j.ajo.2026.01.032","url":null,"abstract":"","PeriodicalId":7568,"journal":{"name":"American Journal of Ophthalmology","volume":"89 1","pages":""},"PeriodicalIF":4.2,"publicationDate":"2026-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146109935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}