American Journal of Ophthalmology最新文献

英文中文

Autograft Donor Site Repair In Pterygium Surgery.

IF 4.1 1区医学 Q1 OPHTHALMOLOGY

American Journal of Ophthalmology

Pub Date : 2025-02-07 DOI: 10.1016/j.ajo.2025.01.025

Minas T Coroneo, Ximena Masgoret, Vijay Reena Durai

引用次数: 0

Titaminates, a Biocompatible Titanium–Organic Hybrid Film, Support the Growth and Function of Conjunctival Epithelial Cells

IF 4.1 1区医学 Q1 OPHTHALMOLOGY

American Journal of Ophthalmology

Pub Date : 2025-02-07 DOI: 10.1016/j.ajo.2025.02.004

Changrim Lee , Veronica Anne-Line Kathrine Killi , Ola Nilsen , Darlene A. Dartt

PURPOSE

To find an ideal biosurface to regenerate conjunctival epithelium.

DESIGN

Experimental study.

METHODS

Pieces of human cadaveric conjunctival epithelium removed of connective tissues were randomly placed on 8 different biosurfaces to grow primary conjunctival epithelial cells for 9 to 14 days until the fastest growing cultures covered 80% to 90% of the film surface. Main outcome measures were growth, proliferation capacity, startification, mucin 5AC (MUC5AC) secretion, and compositional balance in cell types.

RESULTS

All titanium-based films (titaminates) supported the growth, stratification, proliferation, and MUC5AC secretion function of human primary conjunctival epithelial cells (HCjECs), but none of the zinc-based films grew cells at all. Although HCjECs’ ability to proliferate, stratify, and secrete MUC5AC per unit cell area was similar across all titaminates, titanium dioxide (TiO₂) and glycine titaminates (TiG) outperformed TiD and TiGD in terms of outgrowth, recapitulation of native conjunctival epithelium, and compositional balance in cell types. When goblet cells (a subtype of HCjECs) were predominantly grown on these films by using a different culture medium, the results were similar in all aspects.

CONCLUSIONS

Given the body-friendly nature and clinically proven safety and efficacy of titanium, titaminates TiO₂ and TiG have potential as an alternative bioactive substrate for conjunctival epithelium regeneration.

{"title":"Titaminates, a Biocompatible Titanium–Organic Hybrid Film, Support the Growth and Function of Conjunctival Epithelial Cells","authors":"Changrim Lee , Veronica Anne-Line Kathrine Killi , Ola Nilsen , Darlene A. Dartt","doi":"10.1016/j.ajo.2025.02.004","DOIUrl":"10.1016/j.ajo.2025.02.004","url":null,"abstract":"<div><h3>PURPOSE</h3><div>To find an ideal biosurface to regenerate conjunctival epithelium.</div></div><div><h3>DESIGN</h3><div>Experimental study.</div></div><div><h3>METHODS</h3><div>Pieces of human cadaveric conjunctival epithelium removed of connective tissues were randomly placed on 8 different biosurfaces to grow primary conjunctival epithelial cells for 9 to 14 days until the fastest growing cultures covered 80% to 90% of the film surface. Main outcome measures were growth, proliferation capacity, startification, mucin 5AC (MUC5AC) secretion, and compositional balance in cell types.</div></div><div><h3>RESULTS</h3><div>All titanium-based films (titaminates) supported the growth, stratification, proliferation, and MUC5AC secretion function of human primary conjunctival epithelial cells (HCjECs), but none of the zinc-based films grew cells at all. Although HCjECs’ ability to proliferate, stratify, and secrete MUC5AC per unit cell area was similar across all titaminates, titanium dioxide (TiO<sub>2</sub>) and glycine titaminates (TiG) outperformed TiD and TiGD in terms of outgrowth, recapitulation of native conjunctival epithelium, and compositional balance in cell types. When goblet cells (a subtype of HCjECs) were predominantly grown on these films by using a different culture medium, the results were similar in all aspects.</div></div><div><h3>CONCLUSIONS</h3><div>Given the body-friendly nature and clinically proven safety and efficacy of titanium, titaminates TiO<sub>2</sub> and TiG have potential as an alternative bioactive substrate for conjunctival epithelium regeneration.</div></div>","PeriodicalId":7568,"journal":{"name":"American Journal of Ophthalmology","volume":"273 ","pages":"Pages 62-73"},"PeriodicalIF":4.1,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143381667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reply to "Early Versus Delayed Vitrectomy for Vitreous Hemorrhage Secondary to Proliferative Diabetic Retinopathy".

IF 4.1 1区医学 Q1 OPHTHALMOLOGY

American Journal of Ophthalmology

Pub Date : 2025-02-06 DOI: 10.1016/j.ajo.2025.01.024

Rodrigo Anguita, Lorenzo Ferro Desideri, Sobha Sivaprasad, Louisa Wickham

引用次数: 0

Optic Disc Microvasculature Reduction and Visual Field Progression in Primary Open-Angle Glaucoma

IF 4.1 1区医学 Q1 OPHTHALMOLOGY

American Journal of Ophthalmology

Pub Date : 2025-02-05 DOI: 10.1016/j.ajo.2025.02.001

Min Hee Suh , Robert N. Weinreb , Evan Walker , Linda M. Zangwill

Purpose

To investigate the relationship between optic disc vessel density (ODVD) reduction and visual field (VF) progression in primary open-angle glaucoma (POAG) patients.

Design

Retrospective case series.

Methods

A total of 187 POAG eyes underwent ≥5 consecutive VF, spectral-domain optical coherence tomography, and swept-source OCT angiography imaging sessions during ≥3 years of follow-up. ODVD reduction was defined as a statistically significant negative slope (P < .05) of ODVD, calculated as the ratio of pixels occupied by vessels within the temporal optic disc area for any global, superior, or inferior sectors. The association between VF progression and rate of ODVD change was assessed by logistic regression and multivariable longitudinal linear mixed-effects models vs time.

Results

During 3.67 ± 0.38 years of follow-up on the 187 eyes, 90 (48.1%) and 56 (29.9%) showed ODVD reduction and VF progression, respectively. A higher proportion of eyes with ODVD reduction had VF progression than did those without ODVD reduction (51/90 eyes [56.7%] vs 5/97 eyes [5.2%]; P < .001). VF progression was associated with a faster rate of global ODVD change (odds ratio, 5.10; P = .002) as well as a faster rate of global retinal nerve fiber layer thinning (odds ratio, 39.6; P = .008) in the multivariable model.

Conclusions

Optic disc microvasculature reduction was associated with VF progression even after adjusting for possible influencing factors including retinal nerve fiber layer thinning in POAG. This suggests that deep optic nerve head circulation has a role in the pathogenesis of glaucoma.

{"title":"Optic Disc Microvasculature Reduction and Visual Field Progression in Primary Open-Angle Glaucoma","authors":"Min Hee Suh , Robert N. Weinreb , Evan Walker , Linda M. Zangwill","doi":"10.1016/j.ajo.2025.02.001","DOIUrl":"10.1016/j.ajo.2025.02.001","url":null,"abstract":"<div><h3>Purpose</h3><div>To investigate the relationship between optic disc vessel density (ODVD) reduction and visual field (VF) progression in primary open-angle glaucoma (POAG) patients.</div></div><div><h3>Design</h3><div>Retrospective case series.</div></div><div><h3>Methods</h3><div>A total of 187 POAG eyes underwent ≥5 consecutive VF, spectral-domain optical coherence tomography, and swept-source OCT angiography imaging sessions during ≥3 years of follow-up. ODVD reduction was defined as a statistically significant negative slope (<em>P</em> < .05) of ODVD, calculated as the ratio of pixels occupied by vessels within the temporal optic disc area for any global, superior, or inferior sectors. The association between VF progression and rate of ODVD change was assessed by logistic regression and multivariable longitudinal linear mixed-effects models vs time.</div></div><div><h3>Results</h3><div>During 3.67 ± 0.38 years of follow-up on the 187 eyes, 90 (48.1%) and 56 (29.9%) showed ODVD reduction and VF progression, respectively. A higher proportion of eyes with ODVD reduction had VF progression than did those without ODVD reduction (51/90 eyes [56.7%] vs 5/97 eyes [5.2%]; <em>P</em> < .001). VF progression was associated with a faster rate of global ODVD change (odds ratio, 5.10; <em>P</em> = .002) as well as a faster rate of global retinal nerve fiber layer thinning (odds ratio, 39.6; <em>P</em> = .008) in the multivariable model.</div></div><div><h3>Conclusions</h3><div>Optic disc microvasculature reduction was associated with VF progression even after adjusting for possible influencing factors including retinal nerve fiber layer thinning in POAG. This suggests that deep optic nerve head circulation has a role in the pathogenesis of glaucoma.</div></div>","PeriodicalId":7568,"journal":{"name":"American Journal of Ophthalmology","volume":"273 ","pages":"Pages 43-55"},"PeriodicalIF":4.1,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143373570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comment on: Early Versus Delayed Vitrectomy for Vitreous Hemorrhage Secondary to Proliferative Diabetic Retinopathy.

IF 4.1 1区医学 Q1 OPHTHALMOLOGY

American Journal of Ophthalmology

Pub Date : 2025-02-05 DOI: 10.1016/j.ajo.2024.12.033

Salih Uzun, Michael P Blair

引用次数: 0

Comment on: Association Between Glucagon-Like Peptide 1 Receptor Agonists Exposure and Intraocular Pressure Change 评论胰高血糖素样肽 1 (GLP-1) 受体激动剂暴露与眼压变化之间的关系。

IF 4.1 1区医学 Q1 OPHTHALMOLOGY

American Journal of Ophthalmology

Pub Date : 2025-02-01 DOI: 10.1016/j.ajo.2024.09.038

Wei-Zhen Tang, Hao-Wen Chen, Tai-Hang Liu

引用次数: 0

Comment on Ophthalmic Immune-Related Adverse Events and Association With Survival: Results From a Real-World Database 评论《眼科免疫相关不良事件及其与生存的关系：来自真实世界数据库的结果》。

IF 4.1 1区医学 Q1 OPHTHALMOLOGY

American Journal of Ophthalmology

Pub Date : 2025-02-01 DOI: 10.1016/j.ajo.2024.10.034

Flora Lum

引用次数: 0

Reply to Comment on Ophthalmic Immune-Related Adverse Events and Association With Survival: Results From a Real-World Database 对 "眼科免疫相关不良事件及其与存活率的关系：来自真实世界数据库的结果 "评论的回复。

IF 4.1 1区医学 Q1 OPHTHALMOLOGY

American Journal of Ophthalmology

Pub Date : 2025-02-01 DOI: 10.1016/j.ajo.2024.11.001

LEE QUIRUZ , NEGIN YAVARI , BIJAL KIKANI , ANKUR SUDHIR GUPTA , KAREN MICHELLE WAI , ANDREA LORA KOSSLER , CHASE LUDWIG , EUBEE BAUGHN KOO , EHSAN RAHIMY , PRITHVI MRUTHYUNJAYA

引用次数: 0

Response to: “Comment on: Association between Glucagon-Like Peptide 1 Receptor Agonists Exposure and Intraocular Pressure Change” 回应"评论：胰高血糖素样肽 1 (GLP-1) 受体激动剂暴露与眼压变化之间的关系 "的评论。

IF 4.1 1区医学 Q1 OPHTHALMOLOGY

American Journal of Ophthalmology

Pub Date : 2025-02-01 DOI: 10.1016/j.ajo.2024.10.021

Shahin Hallaj , William Halfpenny , Benton G. Chuter , Robert N. Weinreb , Sally L. Baxter , Qi N. Cui

引用次数: 0

Strabismus Surgery in Patients Aged Over 80 Years: Indications, Safety, and Outcomes

IF 4.1 1区医学 Q1 OPHTHALMOLOGY

American Journal of Ophthalmology

Pub Date : 2025-01-31 DOI: 10.1016/j.ajo.2025.01.021

VERONIKA YEHEZKELI , STACY L. PINELES , JOSEPH L. DEMER , QINGYU MENG , FEDERICO G. VELEZ

OBJECTIVE

Strabismus in the elderly can cause functional and psychological difficulties, particularly due to the impact of diplopia. Surgical intervention may alleviate diplopia and diminish psychosocial impact. However, the complexity of strabismus types, along with related ocular conditions and general health issues, pose unique challenges. This study explores the indications, safety, and outcomes of strabismus surgery in patients aged 80 years or more.

DESIGN

Retrospective clinical cohort study.

METHODS

We reviewed patients aged 80 years and older who underwent strabismus surgery at Stein Eye Institute, University of California, Los Angeles, between 2014 and 2024.

RESULTS

The study included 165 patients with a mean age of 83 ± 3 (standard deviation, range 80-94) years, of whom 52% were female. Diplopia was the primary complaint in 94% of patients, with 5 ± 9 years mean symptom duration. The most prevalent diagnosis was sagging eye syndrome, which accounted for 46% of cases. The most common preoperative deviation was combined esotropia and hypertropia (30%). Surgery was performed in 48 patients under general anesthesia and 116 under topical anesthesia. The mean American Society of Anesthesiologists physical status classification score was 2.6 ± 0.5 (range 1-4). No complications occurred during anesthesia or surgery. Diplopia resolved in 124 patients (75%) after the initial surgery, increasing to 145 patients (87%) after one or two additional surgeries. Reoperation was required in 13% of patients overall.

CONCLUSION

Strabismus surgery in patients over 80 years resolves diplopia and improves binocular alignment and stereopsis, without significant complications.

{"title":"Strabismus Surgery in Patients Aged Over 80 Years: Indications, Safety, and Outcomes","authors":"VERONIKA YEHEZKELI , STACY L. PINELES , JOSEPH L. DEMER , QINGYU MENG , FEDERICO G. VELEZ","doi":"10.1016/j.ajo.2025.01.021","DOIUrl":"10.1016/j.ajo.2025.01.021","url":null,"abstract":"<div><h3>OBJECTIVE</h3><div>Strabismus in the elderly can cause functional and psychological difficulties, particularly due to the impact of diplopia. Surgical intervention may alleviate diplopia and diminish psychosocial impact. However, the complexity of strabismus types, along with related ocular conditions and general health issues, pose unique challenges. This study explores the indications, safety, and outcomes of strabismus surgery in patients aged 80 years or more.</div></div><div><h3>DESIGN</h3><div>Retrospective clinical cohort study.</div></div><div><h3>METHODS</h3><div>We reviewed patients aged 80 years and older who underwent strabismus surgery at Stein Eye Institute, University of California, Los Angeles, between 2014 and 2024.</div></div><div><h3>RESULTS</h3><div>The study included 165 patients with a mean age of 83 ± 3 (standard deviation, range 80-94) years, of whom 52% were female. Diplopia was the primary complaint in 94% of patients, with 5 ± 9 years mean symptom duration. The most prevalent diagnosis was sagging eye syndrome, which accounted for 46% of cases. The most common preoperative deviation was combined esotropia and hypertropia (30%). Surgery was performed in 48 patients under general anesthesia and 116 under topical anesthesia. The mean American Society of Anesthesiologists physical status classification score was 2.6 ± 0.5 (range 1-4). No complications occurred during anesthesia or surgery. Diplopia resolved in 124 patients (75%) after the initial surgery, increasing to 145 patients (87%) after one or two additional surgeries. Reoperation was required in 13% of patients overall.</div></div><div><h3>CONCLUSION</h3><div>Strabismus surgery in patients over 80 years resolves diplopia and improves binocular alignment and stereopsis, without significant complications.</div></div>","PeriodicalId":7568,"journal":{"name":"American Journal of Ophthalmology","volume":"272 ","pages":"Pages 145-149"},"PeriodicalIF":4.1,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143078255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

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