Pub Date : 2026-01-30DOI: 10.1016/j.ajo.2026.01.026
Alessandro Feo, Alberto Quarta, Prithvi Ramtohul, Demi Miller, Kareem Moussa, Eric Crowell, K. Bailey Freund, Edmund Tsui
{"title":"Expanded Spectrum of Chrysanthemum and Miliary Multifocal Choroiditis with Panuveitis: Novel Imaging and Pathophysiological Insights","authors":"Alessandro Feo, Alberto Quarta, Prithvi Ramtohul, Demi Miller, Kareem Moussa, Eric Crowell, K. Bailey Freund, Edmund Tsui","doi":"10.1016/j.ajo.2026.01.026","DOIUrl":"https://doi.org/10.1016/j.ajo.2026.01.026","url":null,"abstract":"","PeriodicalId":7568,"journal":{"name":"American Journal of Ophthalmology","volume":"44 1","pages":""},"PeriodicalIF":4.2,"publicationDate":"2026-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146072210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-28DOI: 10.1016/j.ajo.2026.01.027
Pasquale Viggiano, Alice Carra, Gabriele Bruno, Giacomo Boscia, Maria Grazia Pignataro, Alba Chiara Termite, Enrico Borrelli, Michele Reibaldi, Daniela Bacherini, Giovanni Alessio, Mariacristina Parravano, Francesco Boscia
{"title":"Microaneurysm Reflectivity as a prognostic biomarker for intravitreal Treatment Response in Diabetic Retinopathy","authors":"Pasquale Viggiano, Alice Carra, Gabriele Bruno, Giacomo Boscia, Maria Grazia Pignataro, Alba Chiara Termite, Enrico Borrelli, Michele Reibaldi, Daniela Bacherini, Giovanni Alessio, Mariacristina Parravano, Francesco Boscia","doi":"10.1016/j.ajo.2026.01.027","DOIUrl":"https://doi.org/10.1016/j.ajo.2026.01.027","url":null,"abstract":"","PeriodicalId":7568,"journal":{"name":"American Journal of Ophthalmology","volume":"279 1","pages":""},"PeriodicalIF":4.2,"publicationDate":"2026-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146072212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-25DOI: 10.1016/j.ajo.2026.01.020
De-Yi Liu MD, Hou-Ting Kuo MD, Alan Y. Hsu MD, Chun-Ju Lin MD, Yi-Ching Shao MD, Huan-Sheng Chen MD, Chun-Chi Chiang MD PhD, Ning-Yi Hsia MD, Chun-Ting Lai MD, Yu-Hsun Wang, James Cheng-Chung Wei MD PhD, Yi-Yu Tsai MD PhD
To determine the risk of developing glaucoma following a diagnosis of idiopathic non-infectious uveitis and to stratify this risk by uveitis subtype, patient demographics, and corticosteroid use.
{"title":"Risk of Glaucoma in Patients With Idiopathic Non-Infectious Uveitis: A Multi-Institutional Real-World Retrospective Cohort Study","authors":"De-Yi Liu MD, Hou-Ting Kuo MD, Alan Y. Hsu MD, Chun-Ju Lin MD, Yi-Ching Shao MD, Huan-Sheng Chen MD, Chun-Chi Chiang MD PhD, Ning-Yi Hsia MD, Chun-Ting Lai MD, Yu-Hsun Wang, James Cheng-Chung Wei MD PhD, Yi-Yu Tsai MD PhD","doi":"10.1016/j.ajo.2026.01.020","DOIUrl":"https://doi.org/10.1016/j.ajo.2026.01.020","url":null,"abstract":"To determine the risk of developing glaucoma following a diagnosis of idiopathic non-infectious uveitis and to stratify this risk by uveitis subtype, patient demographics, and corticosteroid use.","PeriodicalId":7568,"journal":{"name":"American Journal of Ophthalmology","volume":"1 1","pages":""},"PeriodicalIF":4.2,"publicationDate":"2026-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146047913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-24DOI: 10.1016/j.ajo.2026.01.022
Rupesh Agrawal MD, Aedann See MBBS (Candidate), Faye Ng Yu Ci MBBS, Shyam Sundar MD, Annette Hoskin PhD, Richard Blanch PhD, Sushank Bhalerao MS, Chitaranjan Mishra DNB, Jose Romero MD, Sundaram Natarajan FRCOphth, Gangadhara Sundar FRCSEd, Asia Pacific Ophthalmic Trauma Society (APOTS) Taskforce for the Prevention of Blindness and Disability from Ophthalmic Trauma
Ophthalmic trauma is a substantial yet overlooked public health challenge, pertinent across all age groups, geographies, and socioeconomic statuses. Despite being largely preventable, it constitutes a major cause of monocular vision loss and long-term disability-adjusted life years among ophthalmic conditions, with a disproportionately high burden in low- and middle-income countries. Integrating original data from the International Globe and Adnexal Trauma Epidemiology Study (IGATES) registry, this hybrid perspective provides an overview of the global burden of ophthalmic trauma and emphasizes the urgent need for coordinated public health strategies focused on prevention and intervention.
{"title":"Ophthalmic Trauma: An Overlooked Global Cause of Preventable Blindness and Disability","authors":"Rupesh Agrawal MD, Aedann See MBBS (Candidate), Faye Ng Yu Ci MBBS, Shyam Sundar MD, Annette Hoskin PhD, Richard Blanch PhD, Sushank Bhalerao MS, Chitaranjan Mishra DNB, Jose Romero MD, Sundaram Natarajan FRCOphth, Gangadhara Sundar FRCSEd, Asia Pacific Ophthalmic Trauma Society (APOTS) Taskforce for the Prevention of Blindness and Disability from Ophthalmic Trauma","doi":"10.1016/j.ajo.2026.01.022","DOIUrl":"https://doi.org/10.1016/j.ajo.2026.01.022","url":null,"abstract":"Ophthalmic trauma is a substantial yet overlooked public health challenge, pertinent across all age groups, geographies, and socioeconomic statuses. Despite being largely preventable, it constitutes a major cause of monocular vision loss and long-term disability-adjusted life years among ophthalmic conditions, with a disproportionately high burden in low- and middle-income countries. Integrating original data from the International Globe and Adnexal Trauma Epidemiology Study (IGATES) registry, this hybrid perspective provides an overview of the global burden of ophthalmic trauma and emphasizes the urgent need for coordinated public health strategies focused on prevention and intervention.","PeriodicalId":7568,"journal":{"name":"American Journal of Ophthalmology","volume":"13 1","pages":""},"PeriodicalIF":4.2,"publicationDate":"2026-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146047915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-24DOI: 10.1016/j.ajo.2026.01.002
Sharon Armarnik, Michael Kinori, Tal Yahalomi, Yuval Kozlov, Aya Ekshtein, Leora Levian, Guy Kleinmann, Omer Tehori
{"title":"Corrigendum to “The Natural History of Exophria Progression Among Young Healthy Adults”. Am J Ophthalmol. 2026;282:113-119.","authors":"Sharon Armarnik, Michael Kinori, Tal Yahalomi, Yuval Kozlov, Aya Ekshtein, Leora Levian, Guy Kleinmann, Omer Tehori","doi":"10.1016/j.ajo.2026.01.002","DOIUrl":"https://doi.org/10.1016/j.ajo.2026.01.002","url":null,"abstract":"","PeriodicalId":7568,"journal":{"name":"American Journal of Ophthalmology","volume":"67 1","pages":""},"PeriodicalIF":4.2,"publicationDate":"2026-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146047921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-23DOI: 10.1016/j.ajo.2026.01.019
Lawren Ce T Post,H Rommel Hildreth,William H Crisp,Park Lewis,Edward Jackson,M Uribe Troncoso,Hans Barkan,M F Weymann,Harry S Gradle,John M Wheeler,Emma S Buss,Dr Richard Parrish
{"title":"Reprint of Nationalism Against Science: PUBLISHED MONTHLY BY THE OPHTHALMIC PUBLISHING COMPANY.","authors":"Lawren Ce T Post,H Rommel Hildreth,William H Crisp,Park Lewis,Edward Jackson,M Uribe Troncoso,Hans Barkan,M F Weymann,Harry S Gradle,John M Wheeler,Emma S Buss,Dr Richard Parrish","doi":"10.1016/j.ajo.2026.01.019","DOIUrl":"https://doi.org/10.1016/j.ajo.2026.01.019","url":null,"abstract":"","PeriodicalId":7568,"journal":{"name":"American Journal of Ophthalmology","volume":"17 1","pages":""},"PeriodicalIF":4.2,"publicationDate":"2026-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146044594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
PURPOSENo study has explored the longitudinal association between cardiovascular-kidney-metabolic (CKM) syndrome and age-related macular degeneration (AMD). We aimed to investigate the associations between CKM syndrome, genetic predisposition, and AMD risk.DESIGNRetrospective cohort study.PARTICIPANTSA total of 319,638 participants from the UK Biobank who did not have AMD at baseline.METHODSCKM syndrome was diagnosed based on the presence of chronic kidney disease, cardiovascular disease, and metabolic risk factors. We categorized participants into stage 0-4 according to their CKM syndrome status. A genetic risk score was used to estimate genetic predisposition to AMD. Cox proportional hazards regression models were used to calculate the hazard ratios (HRs) and 95% confidence intervals (CIs) for incident AMD.MAIN OUTCOME MEASURESAMD incidence.RESULTSDuring a median follow-up of 12.5 years, 4,982 AMD cases were identified. After multivariable adjustment, the HRs (95% CIs) for AMD were 1.15 (1.02-1.30), 1.25 (1.13-1.38), 1.22 (1.08-1.38), and 1.48 (1.30-1.68) for participants in CKM stage 1, 2, 3, and 4, respectively, compared to those in CKM stage 0. No significant interaction between genetic predisposition and CKM syndrome was observed (P for interaction = 0.06). Joint analyses showed that compared to those with CKM stage 0 and low genetic predisposition, individuals with CKM stage 4 and high genetic predisposition, exhibited the highest risk of AMD (HR = 2.67, 95% CI: 2.22-3.33).CONCLUSIONSPoor CKM health was positively associated with AMD risk, independent of genetic predisposition.
{"title":"Associations of cardiovascular-kidney-metabolic syndrome with age-related macular degeneration risk.","authors":"Fengyue Wu,Kun Xu,Yuanqi Zhao,Wenxu Wang,Honghao Yang,Yuqian Li,Gang Zheng,Zhenhua Li,Yang Xia,Yashu Liu,Huiying Wu,Song Bai","doi":"10.1016/j.ajo.2026.01.023","DOIUrl":"https://doi.org/10.1016/j.ajo.2026.01.023","url":null,"abstract":"PURPOSENo study has explored the longitudinal association between cardiovascular-kidney-metabolic (CKM) syndrome and age-related macular degeneration (AMD). We aimed to investigate the associations between CKM syndrome, genetic predisposition, and AMD risk.DESIGNRetrospective cohort study.PARTICIPANTSA total of 319,638 participants from the UK Biobank who did not have AMD at baseline.METHODSCKM syndrome was diagnosed based on the presence of chronic kidney disease, cardiovascular disease, and metabolic risk factors. We categorized participants into stage 0-4 according to their CKM syndrome status. A genetic risk score was used to estimate genetic predisposition to AMD. Cox proportional hazards regression models were used to calculate the hazard ratios (HRs) and 95% confidence intervals (CIs) for incident AMD.MAIN OUTCOME MEASURESAMD incidence.RESULTSDuring a median follow-up of 12.5 years, 4,982 AMD cases were identified. After multivariable adjustment, the HRs (95% CIs) for AMD were 1.15 (1.02-1.30), 1.25 (1.13-1.38), 1.22 (1.08-1.38), and 1.48 (1.30-1.68) for participants in CKM stage 1, 2, 3, and 4, respectively, compared to those in CKM stage 0. No significant interaction between genetic predisposition and CKM syndrome was observed (P for interaction = 0.06). Joint analyses showed that compared to those with CKM stage 0 and low genetic predisposition, individuals with CKM stage 4 and high genetic predisposition, exhibited the highest risk of AMD (HR = 2.67, 95% CI: 2.22-3.33).CONCLUSIONSPoor CKM health was positively associated with AMD risk, independent of genetic predisposition.","PeriodicalId":7568,"journal":{"name":"American Journal of Ophthalmology","volume":"31 1","pages":""},"PeriodicalIF":4.2,"publicationDate":"2026-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146044596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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