Pub Date : 2026-01-24DOI: 10.1016/j.ajo.2026.01.002
Sharon Armarnik, Michael Kinori, Tal Yahalomi, Yuval Kozlov, Aya Ekshtein, Leora Levian, Guy Kleinmann, Omer Tehori
{"title":"Corrigendum to “The Natural History of Exophria Progression Among Young Healthy Adults”. Am J Ophthalmol. 2026;282:113-119.","authors":"Sharon Armarnik, Michael Kinori, Tal Yahalomi, Yuval Kozlov, Aya Ekshtein, Leora Levian, Guy Kleinmann, Omer Tehori","doi":"10.1016/j.ajo.2026.01.002","DOIUrl":"https://doi.org/10.1016/j.ajo.2026.01.002","url":null,"abstract":"","PeriodicalId":7568,"journal":{"name":"American Journal of Ophthalmology","volume":"67 1","pages":""},"PeriodicalIF":4.2,"publicationDate":"2026-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146047921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-23DOI: 10.1016/j.ajo.2026.01.019
Lawren Ce T Post,H Rommel Hildreth,William H Crisp,Park Lewis,Edward Jackson,M Uribe Troncoso,Hans Barkan,M F Weymann,Harry S Gradle,John M Wheeler,Emma S Buss,Dr Richard Parrish
{"title":"Reprint of Nationalism Against Science: PUBLISHED MONTHLY BY THE OPHTHALMIC PUBLISHING COMPANY.","authors":"Lawren Ce T Post,H Rommel Hildreth,William H Crisp,Park Lewis,Edward Jackson,M Uribe Troncoso,Hans Barkan,M F Weymann,Harry S Gradle,John M Wheeler,Emma S Buss,Dr Richard Parrish","doi":"10.1016/j.ajo.2026.01.019","DOIUrl":"https://doi.org/10.1016/j.ajo.2026.01.019","url":null,"abstract":"","PeriodicalId":7568,"journal":{"name":"American Journal of Ophthalmology","volume":"17 1","pages":""},"PeriodicalIF":4.2,"publicationDate":"2026-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146044594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
PURPOSENo study has explored the longitudinal association between cardiovascular-kidney-metabolic (CKM) syndrome and age-related macular degeneration (AMD). We aimed to investigate the associations between CKM syndrome, genetic predisposition, and AMD risk.DESIGNRetrospective cohort study.PARTICIPANTSA total of 319,638 participants from the UK Biobank who did not have AMD at baseline.METHODSCKM syndrome was diagnosed based on the presence of chronic kidney disease, cardiovascular disease, and metabolic risk factors. We categorized participants into stage 0-4 according to their CKM syndrome status. A genetic risk score was used to estimate genetic predisposition to AMD. Cox proportional hazards regression models were used to calculate the hazard ratios (HRs) and 95% confidence intervals (CIs) for incident AMD.MAIN OUTCOME MEASURESAMD incidence.RESULTSDuring a median follow-up of 12.5 years, 4,982 AMD cases were identified. After multivariable adjustment, the HRs (95% CIs) for AMD were 1.15 (1.02-1.30), 1.25 (1.13-1.38), 1.22 (1.08-1.38), and 1.48 (1.30-1.68) for participants in CKM stage 1, 2, 3, and 4, respectively, compared to those in CKM stage 0. No significant interaction between genetic predisposition and CKM syndrome was observed (P for interaction = 0.06). Joint analyses showed that compared to those with CKM stage 0 and low genetic predisposition, individuals with CKM stage 4 and high genetic predisposition, exhibited the highest risk of AMD (HR = 2.67, 95% CI: 2.22-3.33).CONCLUSIONSPoor CKM health was positively associated with AMD risk, independent of genetic predisposition.
{"title":"Associations of cardiovascular-kidney-metabolic syndrome with age-related macular degeneration risk.","authors":"Fengyue Wu,Kun Xu,Yuanqi Zhao,Wenxu Wang,Honghao Yang,Yuqian Li,Gang Zheng,Zhenhua Li,Yang Xia,Yashu Liu,Huiying Wu,Song Bai","doi":"10.1016/j.ajo.2026.01.023","DOIUrl":"https://doi.org/10.1016/j.ajo.2026.01.023","url":null,"abstract":"PURPOSENo study has explored the longitudinal association between cardiovascular-kidney-metabolic (CKM) syndrome and age-related macular degeneration (AMD). We aimed to investigate the associations between CKM syndrome, genetic predisposition, and AMD risk.DESIGNRetrospective cohort study.PARTICIPANTSA total of 319,638 participants from the UK Biobank who did not have AMD at baseline.METHODSCKM syndrome was diagnosed based on the presence of chronic kidney disease, cardiovascular disease, and metabolic risk factors. We categorized participants into stage 0-4 according to their CKM syndrome status. A genetic risk score was used to estimate genetic predisposition to AMD. Cox proportional hazards regression models were used to calculate the hazard ratios (HRs) and 95% confidence intervals (CIs) for incident AMD.MAIN OUTCOME MEASURESAMD incidence.RESULTSDuring a median follow-up of 12.5 years, 4,982 AMD cases were identified. After multivariable adjustment, the HRs (95% CIs) for AMD were 1.15 (1.02-1.30), 1.25 (1.13-1.38), 1.22 (1.08-1.38), and 1.48 (1.30-1.68) for participants in CKM stage 1, 2, 3, and 4, respectively, compared to those in CKM stage 0. No significant interaction between genetic predisposition and CKM syndrome was observed (P for interaction = 0.06). Joint analyses showed that compared to those with CKM stage 0 and low genetic predisposition, individuals with CKM stage 4 and high genetic predisposition, exhibited the highest risk of AMD (HR = 2.67, 95% CI: 2.22-3.33).CONCLUSIONSPoor CKM health was positively associated with AMD risk, independent of genetic predisposition.","PeriodicalId":7568,"journal":{"name":"American Journal of Ophthalmology","volume":"31 1","pages":""},"PeriodicalIF":4.2,"publicationDate":"2026-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146044596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-22DOI: 10.1016/j.ajo.2026.01.025
Itay Nitzan
{"title":"Reply to Comment on “Association of Migraine with Increased Risk of Central Serous Chorioretinopathy: A Retrospective Cohort Study”","authors":"Itay Nitzan","doi":"10.1016/j.ajo.2026.01.025","DOIUrl":"https://doi.org/10.1016/j.ajo.2026.01.025","url":null,"abstract":"","PeriodicalId":7568,"journal":{"name":"American Journal of Ophthalmology","volume":"37 1","pages":""},"PeriodicalIF":4.2,"publicationDate":"2026-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146032820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-21DOI: 10.1016/j.ajo.2026.01.018
Antonio Carlos Lottelli, Jessica Lorena Prado Marques, Larissa Gouvea, Rupal H Trivedi, Luíza Alencar Lottelli, M Edward Wilson
{"title":"Mathematical Models for Predicting Postoperative Axial length in Children with Bilateral Cataract and Primary Intraocular Lens Implantation: Toward Improved Pediatric IOL Power Selection","authors":"Antonio Carlos Lottelli, Jessica Lorena Prado Marques, Larissa Gouvea, Rupal H Trivedi, Luíza Alencar Lottelli, M Edward Wilson","doi":"10.1016/j.ajo.2026.01.018","DOIUrl":"https://doi.org/10.1016/j.ajo.2026.01.018","url":null,"abstract":"","PeriodicalId":7568,"journal":{"name":"American Journal of Ophthalmology","volume":"31 1","pages":""},"PeriodicalIF":4.2,"publicationDate":"2026-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146014231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-21DOI: 10.1016/j.ajo.2026.01.024
Jie Chen, Jianchao Li, Chun Zhang
{"title":"Comment on: Association of Migraine With Increased Risk of Central Serous Chorioretinopathy: A Retrospective Cohort Study","authors":"Jie Chen, Jianchao Li, Chun Zhang","doi":"10.1016/j.ajo.2026.01.024","DOIUrl":"https://doi.org/10.1016/j.ajo.2026.01.024","url":null,"abstract":"","PeriodicalId":7568,"journal":{"name":"American Journal of Ophthalmology","volume":"116 1","pages":""},"PeriodicalIF":4.2,"publicationDate":"2026-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146014641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-18DOI: 10.1016/j.ajo.2026.01.013
Mac Thomson, David J. Browning
{"title":"The Hospital Employed Ophthalmologist: A Growing Segment of the Profession","authors":"Mac Thomson, David J. Browning","doi":"10.1016/j.ajo.2026.01.013","DOIUrl":"https://doi.org/10.1016/j.ajo.2026.01.013","url":null,"abstract":"","PeriodicalId":7568,"journal":{"name":"American Journal of Ophthalmology","volume":"38 1","pages":""},"PeriodicalIF":4.2,"publicationDate":"2026-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145995266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-17DOI: 10.1016/j.ajo.2026.01.009
Tomoyuki Wada, Kazunori Omatsu, Stephen C. Pflugfelder
{"title":"Results of a Randomized, Double-Masked, Placebo-Controlled Phase 1/2 Study of a TRPV1 antagonist SJP-0132 in Participants with Dry Eye Disease","authors":"Tomoyuki Wada, Kazunori Omatsu, Stephen C. Pflugfelder","doi":"10.1016/j.ajo.2026.01.009","DOIUrl":"https://doi.org/10.1016/j.ajo.2026.01.009","url":null,"abstract":"","PeriodicalId":7568,"journal":{"name":"American Journal of Ophthalmology","volume":"225 1","pages":""},"PeriodicalIF":4.2,"publicationDate":"2026-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145995270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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