American Journal of Ophthalmology最新文献

{"title":"An AI-Based Prognostic Model for Prediction of Functional Glaucoma Progression from Clinical and Structural Data","authors":"Vahid Mohammadzadeh, Sean Wu, Sajad Besharati, Mahshad Rafiee, Yasamin Banaei, Arthur Martinyan, Jane Zou, Evelyn Kung, Kiumars Edalati, Esteban Morales, Fabien Scalzo, Joseph Caprioli, Kouros Nouri-Mahdavi","doi":"10.1016/j.ajo.2025.12.026","DOIUrl":"https://doi.org/10.1016/j.ajo.2025.12.026","url":null,"abstract":"","PeriodicalId":7568,"journal":{"name":"American Journal of Ophthalmology","volume":"15 1","pages":""},"PeriodicalIF":4.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145893650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Assessment of a Highly Multiplexed Panel Assay for the Diagnosis of Infectious Uveitis.","authors":"Paulo J M Bispo, Nicole L Belanger, Renee Liu, Eduardo Ferracioli-Oda, Tatiana Tanaka, Joyce Hisae Yamamoto, Lucia Sobrin","doi":"10.1016/j.ajo.2025.12.024","DOIUrl":"10.1016/j.ajo.2025.12.024","url":null,"abstract":"<p><strong>Purpose: </strong>Current diagnostic workup for infectious uveitis relies on the use of various immunoassays and PCR tests on ocular fluids that are time consuming and not comprehensive, requiring large sample volumes to probe for all causes. To streamline the diagnosis process, improve turnaround time and target inclusivity, we developed a highly multiplexed pan-ocular-pathogen panel (OcuPan) that can be used for broad-range pathogen detection in only one assay, with PCR-level sensitivity and in a timely fashion (12h). Here, we assessed the clinical usefulness and performance of this innovative assay as a novel tool for rapid and accurate laboratory diagnosis of infectious uveitis.</p><p><strong>Design: </strong>Laboratory evaluation of a novel diagnostic test and technology PARTICIPANTS AND CONTROLS: A total of 109 patients from two centers were included, including 78 infectious uveitis cases and 31 controls.</p><p><strong>Methods: </strong>Intraocular samples (n=108 from patients and 43 from controls) were processed by PCR and the OcuPan diagnostic assay that detects 46 ocular pathogens plus two resistance/virulence markers.</p><p><strong>Main outcome measures: </strong>Clinical sensitivity and specificity, quantification capabilities, and agreement between PCR and the OcuPan assay.</p><p><strong>Results: </strong>The clinical sensitivity and specificity of the OcuPan assay were 50.9% (95% confidence interval [CI]), 41.3 to 60.5) and 100% (95% CI, 89.7% to 100%), respectively. Sensitivity varied according to the sample matrix tested, with undiluted vitreous having the highest positivity rates (72.4%; 95% CI, 55.1 to 89.7), followed by dilute vitreous (53.3%; 95% CI, 34.4 to 72.3) and aqueous (36.7%; 95% CI, 22.7 to 50.7). There was excellent overall agreement (93.5%) between the OcuPan assay and PCR (kappa of 0.870, ±0.047; P <0.001) with positive (PPA) and negative (NPA) percent agreements >92% for all targets. PPA was 100% for herpesviruses and T. pallidum, while the NPA values ranged from 96.6% to 100% for these pathogens. For T. gondii the PPA was 75% and NPA 100%. We also found significant correlation (Spearman rho= -0.7506, P <0.0001) between the quantitative metric for the OcuPan assay and the real time PCR Ct values.</p><p><strong>Conclusions: </strong>The OcuPan assay offers an all-in-one highly multiplexed detection system for rapid, comprehensive, quantitative and accurate diagnosis of infectious uveitis.</p>","PeriodicalId":7568,"journal":{"name":"American Journal of Ophthalmology","volume":" ","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12782286/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145891881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to Comment on Glucagon-like Peptide-1 Receptor Agonist Use and Risk of Cataract Development.","authors":"Abhimanyu S Ahuja, Alfredo A Paredes, Sejal A Ahuja, Benjamin K Young","doi":"10.1016/j.ajo.2025.12.021","DOIUrl":"https://doi.org/10.1016/j.ajo.2025.12.021","url":null,"abstract":"","PeriodicalId":7568,"journal":{"name":"American Journal of Ophthalmology","volume":" ","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145888462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on: Glucagon-like Peptide-1 Receptor Agonist Use and Risk of Cataract Development.","authors":"Ha-Neul Yu, Isdin Oke, Julius T Oatts","doi":"10.1016/j.ajo.2025.11.050","DOIUrl":"https://doi.org/10.1016/j.ajo.2025.11.050","url":null,"abstract":"","PeriodicalId":7568,"journal":{"name":"American Journal of Ophthalmology","volume":" ","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145877474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of Sodium-Glucose Cotransporter 2 Inhibitors and Glucagon-Like Peptide-1 Receptor Agonists with Risk of Cataract","authors":"Bing-Hua Lin, Shu-Han Chuang, Lien-Chen Wu, Yu-Pin Chen, Yi-Jie Kuo, Cheng-Hsien Chang","doi":"10.1016/j.ajo.2025.12.025","DOIUrl":"https://doi.org/10.1016/j.ajo.2025.12.025","url":null,"abstract":"","PeriodicalId":7568,"journal":{"name":"American Journal of Ophthalmology","volume":"126 1","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145844794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The AJO and Academic Freedom: Then and Now","authors":"Richard K. Parrish","doi":"10.1016/j.ajo.2025.12.023","DOIUrl":"https://doi.org/10.1016/j.ajo.2025.12.023","url":null,"abstract":"","PeriodicalId":7568,"journal":{"name":"American Journal of Ophthalmology","volume":"29 1","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145844795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Elevated RNV on Widefield OCTA Predicts Complications in High-Risk PDR","authors":"An-Lun Wu, Jinyi Hao, Liqin Gao, Yukun Guo, Tristan T. Hormel, Christina J. Flaxel, Merina Thomas, Benjamin K. Young, Steven T. Bailey, Dong-Wouk Park, Yali Jia, Thomas S. Hwang","doi":"10.1016/j.ajo.2025.12.017","DOIUrl":"https://doi.org/10.1016/j.ajo.2025.12.017","url":null,"abstract":"","PeriodicalId":7568,"journal":{"name":"American Journal of Ophthalmology","volume":"9 1","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145822818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Geographic and Phenotypic Variability in RHO-Associated Retinopathy: Evidence from a Chinese Cohort and Global Literature","authors":"Chenyue Hang, Tianyuan Zhao, Zhixuan Chen, Hong Wang, Lin Chen, Ting Zhang, Yutian Jiao, Tong Li, Junran Sun, Suqin Yu, Yuanyuan Gong, Hao Zhou, Xujun Jiang, Xinxin Liu, Huixun Jia, Kairong Zheng, Xiaoling Wan, Jieqiong Chen, Xiaodong Sun","doi":"10.1016/j.ajo.2025.12.020","DOIUrl":"https://doi.org/10.1016/j.ajo.2025.12.020","url":null,"abstract":"","PeriodicalId":7568,"journal":{"name":"American Journal of Ophthalmology","volume":"7 1","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145823647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Natural history of CNGA1-associated retinitis pigmentosa in a large Chinese cohort revealing an optimal intervention window","authors":"Yue Liu, Dingding Zhang, Yunyu Zhou, Yamei Li, Xiaoxu Han, Zixi Sun, Xing Wei, Hui Li, Xuan Zou, Ruifang Sui","doi":"10.1016/j.ajo.2025.12.018","DOIUrl":"https://doi.org/10.1016/j.ajo.2025.12.018","url":null,"abstract":"","PeriodicalId":7568,"journal":{"name":"American Journal of Ophthalmology","volume":"14 1","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145822822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gonioscopy Assisted Transluminal Trabeculotomy (GATT) as a viable intervention for Neovascular Glaucoma","authors":"Avilasha Mohapatra, Vyshak Suresh, Sushmita Kaushik","doi":"10.1016/j.ajo.2025.12.016","DOIUrl":"https://doi.org/10.1016/j.ajo.2025.12.016","url":null,"abstract":"","PeriodicalId":7568,"journal":{"name":"American Journal of Ophthalmology","volume":"28 1","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145822821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}