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Diagnosis and prognostic predictive value of delineation methods from 18F-FDG PET/CT and PET/MR in pancreatic lesion. 18F-FDG PET/CT 和 PET/MR 对胰腺病变的诊断和预后预测价值。
IF 2.5 Pub Date : 2023-12-25 eCollection Date: 2023-01-01
Fan Hu, Xiao Zhang, Hua Shu, Xiaoli Wang, Shuqian Feng, Mengmeng Hu, Xiaoli Lan, Chunxia Qin

The aim was to utilize three segmentation methods on 18F-FDG PET/CT and PET/MR images of pancreatic neoplasm patients, and further compare the effectiveness in differentiating benign from malignant, TNM-stage and prognosis. We conducted a retrospective analysis of 51 patients with pancreatic neoplasm who had undergone 18F-FDG PET/CT and PET/MR before treatment. The patients were categorized into malignant and benign groups. For each patient, the lesion was segmented by 3 thresholds and we recorded TNM-stage, treatment strategy, time to death, and the performance status of survivors. We used receiver operating characteristic (ROC) analysis to compare the diagnostic performance of different threshold delineations between benign and malignant, as well as TNM-stage of adenocarcinoma patients. The optimal model of prognostic value was also assessed by Cox proportional hazards regression analysis and Kaplan-Meier survival analysis. For both PET/CT and PET/MR, SUVmax had the best diagnostic efficacy in identifying malignant tumors. The background method of PET/MR exhibited the outstanding performance in M-stage (sensitivity/specificity, 92.90%/88.20%), with the weighted factor being whole-body total lesion glycolysis (WBTLG). In multivariate analysis, WBTLG (Exp [B] = 1.009; P = 0.009), and surgery (Exp [B] = 15.542; P = 0.008) were independent predictive factors associated with prognosis. This study found that SUVmax from PET/CT had the best diagnostic efficacy in identifying malignancy, while PET/MR showed higher specificity and accuracy for M-stage. The treatment strategy and WBTLG were independent prognostic factors in pancreatic neoplasm patients. PET/MR using the background method was identified as the optimal predictive model for prognosis.

目的是利用三种分割方法对胰腺肿瘤患者的 18F-FDG PET/CT 和 PET/MR 图像进行分割,并进一步比较其在区分良恶性、TNM 分期和预后方面的效果。我们对 51 名在治疗前接受过 18F-FDG PET/CT 和 PET/MR 检查的胰腺肿瘤患者进行了回顾性分析。患者被分为恶性组和良性组。我们对每位患者的病灶按 3 个阈值进行了分割,并记录了 TNM 分期、治疗策略、死亡时间和幸存者的表现状态。我们使用接收器操作特征(ROC)分析来比较不同阈值在良性和恶性之间的诊断性能,以及腺癌患者的TNM分期。此外,还通过 Cox 比例危险回归分析和 Kaplan-Meier 生存分析评估了预后价值的最佳模型。对于 PET/CT 和 PET/MR,SUVmax 在识别恶性肿瘤方面的诊断效果最好。PET/MR 的背景方法在 M 分期中表现突出(灵敏度/特异度,92.90%/88.20%),加权因子为全身总病灶糖酵解(WBTLG)。在多变量分析中,WBTLG(Exp [B] = 1.009; P = 0.009)和手术(Exp [B] = 15.542; P = 0.008)是与预后相关的独立预测因素。本研究发现,PET/CT 的 SUVmax 在鉴别恶性肿瘤方面具有最佳诊断效果,而 PET/MR 对 M 期显示出更高的特异性和准确性。治疗策略和 WBTLG 是胰腺肿瘤患者的独立预后因素。使用背景法的 PET/MR 被确定为预后的最佳预测模型。
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引用次数: 0
Dive into the details of radionuclide antibody conjugates: what role do EPR effects and LETs of different radionuclides play? 深入了解放射性核素抗体共轭物的细节:不同放射性核素的 EPR 效应和 LET 起什么作用?
IF 2.5 Pub Date : 2023-12-25 eCollection Date: 2023-01-01
Sixuan Cheng, Dawei Jiang, Mengting Li

Radionuclide antibody conjugate (RAC) is a promising diagnostic and therapeutic tool. It combines radionuclides and antibodies by connecting arms and chelating agents, offering precise targeting and potent killing of tumor cells. However, further development and optimization of this radiopharmaceutical is needed to enhance the ultimate substantive efficacy for clinical translation. In this issue of AJNMMI, Strand et al. evaluated the enhanced permeability effect and different linear energy transfer (LET) of radionuclides in a prostate cancer xenograft model. The results showed that specific targeting might negatively influence normal organ uptake when targeting secreted antigens and different LETs of radionuclides might have diverse effects on receptor expression and cell proliferation in tumors. The findings provide new thinking for the development of antibody-based radiopharmaceuticals.

放射性核素抗体共轭物(RAC)是一种前景广阔的诊断和治疗工具。它通过连接臂和螯合剂将放射性核素和抗体结合在一起,对肿瘤细胞具有精确靶向和强效杀伤作用。然而,这种放射性药物还需要进一步开发和优化,以提高最终的实质性疗效,实现临床转化。在本期 AJNMMI 杂志上,Strand 等人评估了放射性核素在前列腺癌异种移植模型中的增强渗透效应和不同的线性能量转移 (LET)。结果表明,当靶向分泌型抗原时,特异性靶向可能会对正常器官的吸收产生负面影响,而不同线性能量转移(LET)的放射性核素可能会对肿瘤中的受体表达和细胞增殖产生不同的影响。这些发现为开发基于抗体的放射性药物提供了新思路。
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引用次数: 0
Malignant melanoma of gastrointestinal tract on 18F-FDG PET/CT: three case reports. 18F-FDG PET/CT 胃肠道恶性黑色素瘤:三份病例报告。
IF 2.5 Pub Date : 2023-12-25 eCollection Date: 2023-01-01
Wenpeng Huang, Yongkang Qiu, Xiaoyan Xiao, Liming Li, Qi Yang, Jianbo Gao, Lei Kang

Primary malignant melanoma most frequently occurs in the skin. Melanoma affecting the gastrointestinal (GI) tract has been substantiated for lesions occurring in the esophagus, stomach, small bowel, and anorectum through multiple published reports, given the presence of melanocytes in these areas. Nevertheless, owing to the exceedingly low incidence of this disease, reports on its clinical features are few, and treatment approaches lack standardization. In this study, we present three cases of GI melanoma with imaging manifestations, emphasizing the pivotal role of 18F-FDG PET/CT in staging for GI melanoma. Establishing a definitive diagnosis of primary GI melanoma necessitates the exclusion of the possibility of metastasis from more prevalent primary sites. Advancements in molecular imaging technologies and the development of novel tracers provided significant promising methods for enhancing the diagnosis and management of melanoma, contributing to improved patient outcomes and overall disease management.

原发性恶性黑色素瘤最常发生在皮肤上。由于食道、胃、小肠和肛门直肠等部位存在黑色素细胞,多篇已发表的报告证实,发生在这些部位的黑色素瘤会影响胃肠道。然而,由于这种疾病的发病率极低,有关其临床特征的报道也很少,治疗方法也缺乏标准化。在本研究中,我们介绍了三例有影像学表现的消化道黑色素瘤,强调了 18F-FDG PET/CT 在消化道黑色素瘤分期中的关键作用。要明确诊断原发性消化道黑色素瘤,就必须排除更常见的原发部位转移的可能性。分子成像技术的进步和新型示踪剂的开发为加强黑色素瘤的诊断和管理提供了大有可为的方法,有助于改善患者预后和整体疾病管理。
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引用次数: 0
Multimodality imaging of an unusual giant cell tumor of thoracic spine with mediastinal invasion: a case report. 胸椎异常巨细胞瘤伴纵隔侵犯的多模式成像:病例报告。
IF 2.5 Pub Date : 2023-12-25 eCollection Date: 2023-01-01
Wenpeng Huang, Yushuo Peng, Yongbai Zhang, Fangfang Chao, Liming Li, Yongkang Qiu, Jianbo Gao, Lei Kang

Giant cell tumor (GCT) is a benign yet locally aggressive bone neoplasm typically situated in the juxta-articular metaphysis of long bones. Although spinal involvement is rare, it is predominantly reported in the axial skeleton, with the sacrum being the primary location. Conversely, GCTs are notably uncommon in the thoracic spine. In this report, we present computed tomography (CT), magnetic resonance imaging (MRI), and 2-Deoxy-2-[fluorine-18]-fluoro-D-glucose (18F-FDG) positron emission tomography combined with computed tomography (PET/CT) multimodality imaging findings of a 36-year-old woman diagnosed with a GCT of the thoracic spine. CT scans provide a precise evaluation of cortical thinning and penetration. While MRI lacks specific diagnostic indicators for GCT, it remains invaluable for delineating the extent of soft tissue expansion and the tumor's relationship with intraspinal neural elements - critical information for surgical planning. 18F-FDG PET/CT effectively illustrates the lesion's hypermetabolic and locally aggressive characteristics. It is noteworthy that GCT occasionally exhibits metastatic malignant potential, underscoring the value of FDG PET as a pivotal modality for staging, restaging, or assessing therapy response, and for monitoring the efficacy of radiotherapy. Familiarity with the imaging features of GCT is essential for physicians to avoid misinterpretation. This tumor should be considered in the differential diagnosis of spinal tumors, distinguishing it from bone metastases or neurogenic tumors.

巨细胞瘤(GCT)是一种良性但具有局部侵袭性的骨肿瘤,通常发生在长骨的干骺端。虽然脊柱受累很少见,但主要发生在轴向骨骼,骶骨是主要部位。相反,胸椎的 GCT 却并不常见。在本报告中,我们介绍了一名被诊断为胸椎 GCT 的 36 岁女性的计算机断层扫描(CT)、磁共振成像(MRI)和 2-脱氧-2-[氟-18]-氟-D-葡萄糖(18F-FDG)正电子发射断层扫描联合计算机断层扫描(PET/CT)多模态成像结果。CT 扫描可精确评估皮质变薄和穿透情况。虽然核磁共振成像缺乏针对 GCT 的特异性诊断指标,但它在描述软组织扩张程度以及肿瘤与椎管内神经元的关系方面仍然非常有价值,是手术规划的关键信息。18F-FDG PET/CT 能有效说明病变的高代谢性和局部侵袭性特征。值得注意的是,GCT 偶尔会出现转移性恶性潜能,这凸显了 FDG PET 作为分期、重新分期或评估治疗反应以及监测放疗疗效的重要方式的价值。熟悉 GCT 的成像特征对医生避免误诊至关重要。在脊柱肿瘤的鉴别诊断中应考虑这种肿瘤,将其与骨转移或神经源性肿瘤区分开来。
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引用次数: 0
Application of quantitative orbital analysis to assess the activity of Graves' ophthalmopathy. 应用眼眶定量分析评估巴塞杜氏眼病的活动性。
IF 2.5 Pub Date : 2023-12-25 eCollection Date: 2023-01-01
Shuang Li, Yue-Jun Liu

This study aimed to evaluate the diagnostic value of uptake ratios in the extraocular muscles (EOMs), lacrimal glands, and optic nerves to detect the inflammation activity of Graves' ophthalmopathy (GO) using quantitative analysis of 99m technetium (99mTc)-labeled diethylene triamine pentaacetic acid (DTPA) orbital single-photon emission computed tomography/computed tomography (SPECT/CT) images. The patients were categorized into an active stage (clinical activity score ≥ 3/7, n=23) or an inactive stage (clinical activity score < 3/7, n=38), based on their clinical activity score. The uptake ratio was manually determined by placing a region of interest within the area of highest uptake, as agreed upon by consensus, in the EOMs, lacrimal gland, and optic nerve on SPECT images corrected for CT attenuation. Patients with active GO exhibited significantly higher uptake ratios in the EOMs, lacrimal glands, and optic nerves compared to patients with inactive GO (all P < 0.01). These parameters have been proven effective in differentiating between active and inactive disease.

本研究旨在通过定量分析99m锝(99mTc)标记的二乙三胺五醋酸(DTPA)眼眶单光子发射计算机断层扫描(SPECT/CT)图像,评估眼外肌(EOMs)、泪腺和视神经的摄取比率对检测巴塞杜氏眼病(Graves' ophthalmopathy,GO)炎症活动的诊断价值。根据临床活动评分,将患者分为活动期(临床活动评分≥ 3/7,23 人)和非活动期(临床活动评分< 3/7,38 人)。摄取比是人工确定的,方法是在SPECT图像上经CT衰减校正的EOM、泪腺和视神经摄取最高的区域内放置一个感兴趣区。与非活动性GO患者相比,活动性GO患者的眼表、泪腺和视神经的摄取率明显更高(P均<0.01)。这些参数已被证明能有效区分活动性和非活动性疾病。
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引用次数: 0
Incidence of 99Tc-MDP uptake in the external occipital protuberance in the pediatric population: the new normal? 儿童枕外隆突患者99Tc-MDP摄取的发生率:新常态?
IF 2.5 Pub Date : 2023-10-20 eCollection Date: 2023-01-01
Razi Muzaffar, Amer Alassi, Mohamed Mashal, Medhat M Osman

Background: Children and young adults have a vast array of electronics at their fingertips. While it can provide endless hours of entertainment and education, we are also seeing a structural consequence. Children are using these devices with their head tilted down with poor posture resulting in increased stress on the skull from attached structures which can lead to a bone spur (exostosis) at the external occipital protuberance (EOP). While typically painless, it can progress to necessitate surgical intervention.

Objectives: The purpose of this study is to understand the prevalence of exostosis at the EOP and how the finding can affect the nuclear medicine bone scan.

Materials and methods: 43 pediatric patients who underwent a whole-body bone scan over a period of 1 year were included in the study (10-19 years old). Images were reviewed by 2 board-certified Nuclear Medicine physicians to assess for uptake midline in the occipital skull. Suspected cases were followed up with all available clinical and radiographic reports and images.

Results: Bone scan demonstrated an occipital focus of uptake in 7 (16%) of the 43 patients (5 males and 2 females with a mean age of 15 years; range 10-19). Of these, 5/7 (71%) were confirmed by additional imaging.

Conclusion: The rapidly advancing technology is leading to increased screen time in children and young adults. Our study shows that 16% of the pediatric population imaged at our facility between the ages of 10-19 years have signs of exostosis at the EOP. It is particularly important for clinicians to be aware of this entity when reading bone scans to avoid false positive interpretations.

背景:儿童和年轻人的指尖上有大量的电子产品。虽然它可以提供无尽的娱乐和教育时间,但我们也看到了结构性后果。儿童使用这些设备时,头部向下倾斜,姿势不佳,导致附着结构对头骨的压力增加,从而导致枕骨外隆突(EOP)的骨刺(外生骨骺)。虽然通常是无痛的,但它可以发展到需要手术干预。目的:本研究的目的是了解外植骨在EOP的患病率以及该发现如何影响核医学骨扫描。材料和方法:研究纳入了43例在1年内接受全身骨扫描的儿童患者(10-19岁)。影像由2名核医学医师审查,以评估枕颅骨中线摄取情况。利用所有可用的临床和放射报告和图像对疑似病例进行随访。结果:43例患者(5男2女,平均年龄15岁)中,骨扫描显示7例(16%)为枕部摄取病灶;范围10 - 19)。其中5/7(71%)经附加影像学证实。结论:快速发展的技术正在导致儿童和年轻人的屏幕时间增加。我们的研究表明,在我们医院接受影像学检查的10-19岁的儿童中,有16%在EOP有外生症的迹象。对于临床医生来说,在阅读骨骼扫描以避免误报解释时,意识到这一点尤为重要。
{"title":"Incidence of 99Tc-MDP uptake in the external occipital protuberance in the pediatric population: the new normal?","authors":"Razi Muzaffar, Amer Alassi, Mohamed Mashal, Medhat M Osman","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Children and young adults have a vast array of electronics at their fingertips. While it can provide endless hours of entertainment and education, we are also seeing a structural consequence. Children are using these devices with their head tilted down with poor posture resulting in increased stress on the skull from attached structures which can lead to a bone spur (exostosis) at the external occipital protuberance (EOP). While typically painless, it can progress to necessitate surgical intervention.</p><p><strong>Objectives: </strong>The purpose of this study is to understand the prevalence of exostosis at the EOP and how the finding can affect the nuclear medicine bone scan.</p><p><strong>Materials and methods: </strong>43 pediatric patients who underwent a whole-body bone scan over a period of 1 year were included in the study (10-19 years old). Images were reviewed by 2 board-certified Nuclear Medicine physicians to assess for uptake midline in the occipital skull. Suspected cases were followed up with all available clinical and radiographic reports and images.</p><p><strong>Results: </strong>Bone scan demonstrated an occipital focus of uptake in 7 (16%) of the 43 patients (5 males and 2 females with a mean age of 15 years; range 10-19). Of these, 5/7 (71%) were confirmed by additional imaging.</p><p><strong>Conclusion: </strong>The rapidly advancing technology is leading to increased screen time in children and young adults. Our study shows that 16% of the pediatric population imaged at our facility between the ages of 10-19 years have signs of exostosis at the EOP. It is particularly important for clinicians to be aware of this entity when reading bone scans to avoid false positive interpretations.</p>","PeriodicalId":7572,"journal":{"name":"American journal of nuclear medicine and molecular imaging","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2023-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10656627/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138457235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The performance and applied value of 18F-FDG PET/CT imaging in Waldenstrom macroglobulinemia. 18F-FDG PET/CT在Waldenstrom巨球蛋白血症中的表现及应用价值。
IF 2.5 Pub Date : 2023-10-20 eCollection Date: 2023-01-01
Bo Pan, Xingxing Zhu, Qiang Xie

Waldenstrom macroglobulinemia (WM) is a rare inert B lymphocyte lymphoma and the role of FDG PET/CT imaging in WM has not been well established. This study aimed to evaluate the metabolic status of WM by 18F-FDG PET/CT imaging. We retrospectively analyzed 20 patients who underwent pretherapy 18F-FDG PET-CT scan. All patients were diagnosed by bone marrow aspiration, laboratory examination and clinical symptoms. Bone marrow involvement was identified with 18F-FDG PET/CT imaging in 16 of 20, and the mean SUVmax of bone marrow was 4.06±0.85, Lymph nodes were involved in 8 of 20 patients, and the mean SUVmax of Lymph nodes was 4.07±1.27. Liver and spleen were involved in one case respectively, with SUVmax being 3.6 and 3.3. 1 case of extramedullary infiltration and 1 case of lymphomatous transformation. 18F-FDG PET/CT imaging not only could reveal the metabolic status of lymph nodes, liver, spleen and bone marrow in WM patients, but also evaluate the status of tumor burden which helps to formulate personalized treatment plans.

Waldenstrom巨球蛋白血症(WM)是一种罕见的惰性B淋巴细胞淋巴瘤,FDG PET/CT成像在WM中的作用尚未得到很好的确定。本研究旨在通过18F-FDG PET/CT成像评估WM的代谢状态。我们回顾性分析了20例接受治疗前18F-FDG PET-CT扫描的患者。所有患者均通过骨髓穿刺、实验室检查和临床症状确诊。20例患者中有16例经18F-FDG PET/CT检查发现骨髓受累,骨髓平均SUVmax为4.06±0.85,8例患者受累淋巴结,平均SUVmax为4.07±1.27。累及肝脏和脾脏各1例,SUVmax分别为3.6和3.3。髓外浸润1例,淋巴瘤转化1例。18F-FDG PET/CT成像不仅可以显示WM患者的淋巴结、肝脏、脾脏和骨髓的代谢状况,还可以评估肿瘤负荷状况,有助于制定个性化的治疗方案。
{"title":"The performance and applied value of <sup>18</sup>F-FDG PET/CT imaging in Waldenstrom macroglobulinemia.","authors":"Bo Pan, Xingxing Zhu, Qiang Xie","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Waldenstrom macroglobulinemia (WM) is a rare inert B lymphocyte lymphoma and the role of FDG PET/CT imaging in WM has not been well established. This study aimed to evaluate the metabolic status of WM by <sup>18</sup>F-FDG PET/CT imaging. We retrospectively analyzed 20 patients who underwent pretherapy <sup>18</sup>F-FDG PET-CT scan. All patients were diagnosed by bone marrow aspiration, laboratory examination and clinical symptoms. Bone marrow involvement was identified with <sup>18</sup>F-FDG PET/CT imaging in 16 of 20, and the mean SUVmax of bone marrow was 4.06±0.85, Lymph nodes were involved in 8 of 20 patients, and the mean SUVmax of Lymph nodes was 4.07±1.27. Liver and spleen were involved in one case respectively, with SUVmax being 3.6 and 3.3. 1 case of extramedullary infiltration and 1 case of lymphomatous transformation. <sup>18</sup>F-FDG PET/CT imaging not only could reveal the metabolic status of lymph nodes, liver, spleen and bone marrow in WM patients, but also evaluate the status of tumor burden which helps to formulate personalized treatment plans.</p>","PeriodicalId":7572,"journal":{"name":"American journal of nuclear medicine and molecular imaging","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2023-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10656628/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138457238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Diagnostic efficacy of C-X-C motif chemokine receptor 4-directed PET/CT in newly diagnosed head and neck squamous cell carcinoma - a head-to-head comparison with [18F]FDG. C-X-C基序趋化因子受体4定向PET/CT在新诊断的头颈部鳞状细胞癌中的诊断效果-与[18F]FDG的直接比较。
IF 2.5 Pub Date : 2023-10-20 eCollection Date: 2023-01-01
Yingjun Zhi, Rudolf A Werner, Andreas Schirbel, Takahiro Higuchi, Andreas K Buck, Aleksander Kosmala, Thorsten A Bley, Rudolf Hagen, Stephan Hackenberg, Andreas Rosenwald, Agmal Scherzad, Elena Gerhard-Hartmann, Sebastian E Serfling

Background: The aim of this study was to determine the read-out capabilities of the novel C-X-C motif chemokine receptor 4 (CXCR4)-targeting radiotracer [68Ga]Ga-PentixaFor compared to the reference radiotracer [18F]FDG in untreated individuals with head and neck squamous cell carcinoma (HNSCC).

Material and methods: 12 patients with histologically confirmed HNSCC were scheduled for [18F]FDG and [68Ga]Ga-PentixaFor PET/CT. Maximum standardized uptake values (SUVmax) and target-to-background ratios (TBR) were applied with vena cava superior serving as reference. In addition, we compared [68Ga]Ga-PentixaFor-PET findings with immunohistochemical (IHC) results of CXCR4 expression.

Results: On visual assessment, [18F]FDG identified more sites of disease, with increased detection rates for both the primary tumor ([18F]FDG, 12/12 [100%] vs. [68Ga]Ga-PentixaFor, 10/12 [83%]) and LN metastases ([18F]FDG, 9/12 [75%] vs. [68Ga]Ga-PentixaFor, 8/12 [67%]). Indicative for improved image contrast using [18F]FDG, quantification showed a higher TBR for the latter radiotracer, when compared to [68Ga]Ga-PentixaFor for all lesions ([18F]FDG, 11.7 ± 8.5 vs. [68Ga]Ga-PentixaFor, 4.3 ± 1.3; P=0.03), primary tumors ([18F]FDG, 13.6 ± 8.7 vs. [68Ga]Ga-PentixaFor, 4.4 ± 1.4; P<0.01), and LN lesions ([18F]FDG, 9.3 ± 10.6 vs. [68Ga]Ga-PentixaFor, 4.7 ± 1.5; P=0.3). IHC showed variable CXCR4 expression in the primary and LN, along with no associations between ex-vivo CXCR4 upregulation and [68Ga]Ga-PentixaFor-based TBR (R=0.33, P=0.39) or SUVmax (R=0.44, P=0.2). Of note, IHC also revealed heterogeneous expression of CXCR4 in immune cells in the tumor microenvironment and in germinal centers, indicative for inflammatory reactions.

Conclusions: In HNSCC, [18F]FDG demonstrated superior diagnostic performance relative to [68Ga]Ga-PentixaFor, in particular for assessment of the primary. Based on the IHC analyses, these findings may be explained by CXCR4 upregulation not only by tumor but also by immune cells in the tumor microenvironment.

背景:本研究的目的是确定新型C-X-C基序列趋化因子受体4 (CXCR4)靶向放射性示踪剂[68Ga]Ga-PentixaFor与参考放射性示踪剂[18F]FDG在未治疗的头颈部鳞状细胞癌(HNSCC)患者中的读取能力。材料与方法:对12例经组织学证实的HNSCC患者进行[18F]FDG和[68Ga]Ga-PentixaFor PET/CT检查。最大标准摄取值(SUVmax)和目标-背景比(TBR)以上腔静脉为参照。此外,我们比较了[68Ga] ga - pentixa - for - pet结果与CXCR4表达的免疫组化(IHC)结果。结果:在目测方面,[18F]FDG识别出更多的疾病部位,原发肿瘤的检出率([18F]FDG, 12/12 [100%] vs. [68Ga]Ga-PentixaFor, 10/12[83%])和LN转移瘤的检出率([18F]FDG, 9/12 [75%] vs. [68Ga]Ga-PentixaFor, 8/12[67%])均有所增加。定量显示,与[68Ga]Ga-PentixaFor相比,[18F]FDG改善了图像对比度,后一种放射性示踪剂的TBR更高,对于所有病变([18F]FDG, 11.7±8.5比[68Ga]Ga-PentixaFor, 4.3±1.3;P=0.03),原发肿瘤([18F]FDG, 13.6±8.7 vs. [68Ga]Ga-PentixaFor, 4.4±1.4;P18F]FDG, 9.3±10.6 vs. [68Ga]Ga-PentixaFor, 4.7±1.5;P = 0.3)。IHC显示原发性和LN中CXCR4表达变化,体外CXCR4上调与[68Ga] ga - pentixafortbr (R=0.33, P=0.39)或SUVmax (R=0.44, P=0.2)之间无关联。值得注意的是,免疫组化还揭示了CXCR4在肿瘤微环境和生发中心的免疫细胞中的异质表达,表明了炎症反应。结论:在HNSCC中,[18F]FDG相对于[68Ga]Ga-PentixaFor表现出更好的诊断性能,特别是在原发性肿瘤的评估方面。基于免疫组化分析,这些发现可以解释为肿瘤和肿瘤微环境中的免疫细胞中CXCR4的上调。
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引用次数: 0
Marriage of radiotracers and total-body PET/CT rapid imaging system: current status and clinical advances. 放射性示踪剂与全身PET/CT快速成像系统的结合:现状及临床进展。
IF 2.5 Pub Date : 2023-10-20 eCollection Date: 2023-01-01
Yuxuan Wu, Xiaona Sun, Boyang Zhang, Siqi Zhang, Xingkai Wang, Zhicheng Sun, Ruping Liu, Mingrong Zhang, Kuan Hu

Radiotracers and medical imaging equipment are the two main keys to molecular imaging. While radiotracers are of great interest to research and industry, medical imaging equipment technology is blossoming everywhere. Total-body PET/CT (TB-PET/CT) has emerged in response to this trend and is rapidly gaining traction in the fields of clinical oncology, cardiovascular medicine, inflammatory/infectious diseases, and pediatric diseases. In addition, the use of a growing number of radiopharmaceuticals in TB-PET/CT systems has shown promising results. Notably, the distinctive features of TB-PET/CT, such as its ultra-long axial field of view (194 cm), ultra-high sensitivity, and capability for low-dose tracer imaging, have enabled enhanced imaging quality while reducing the radiation dose. The envisioned whole-body dynamic imaging, delayed imaging, personalized disease management, and ultrafast acquisition for motion correction, among others, are achieved. This review highlights two key factors affecting molecular imaging, describing the rapid imaging effects of radiotracers allowed at low doses on TB-PET/CT and the improvements offered compared to conventional PET/CT.

放射性示踪剂和医学成像设备是分子成像的两个主要关键。虽然放射性示踪剂在研究和工业中引起了极大的兴趣,但医疗成像设备技术正在各地蓬勃发展。全身PET/CT (TB-PET/CT)顺应这一趋势应运而生,在临床肿瘤学、心血管医学、炎症/感染性疾病和儿科疾病等领域迅速获得关注。此外,在TB-PET/CT系统中使用越来越多的放射性药物已经显示出有希望的结果。值得注意的是,TB-PET/CT的独特特点,如超长轴向视场(194厘米)、超高灵敏度和低剂量示踪成像能力,在降低辐射剂量的同时提高了成像质量。实现了预想的全身动态成像、延迟成像、个性化疾病管理和用于运动矫正的超快速采集等。这篇综述强调了影响分子成像的两个关键因素,描述了低剂量放射性示踪剂在TB-PET/CT上的快速成像效果,以及与传统PET/CT相比所提供的改进。
{"title":"Marriage of radiotracers and total-body PET/CT rapid imaging system: current status and clinical advances.","authors":"Yuxuan Wu, Xiaona Sun, Boyang Zhang, Siqi Zhang, Xingkai Wang, Zhicheng Sun, Ruping Liu, Mingrong Zhang, Kuan Hu","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Radiotracers and medical imaging equipment are the two main keys to molecular imaging. While radiotracers are of great interest to research and industry, medical imaging equipment technology is blossoming everywhere. Total-body PET/CT (TB-PET/CT) has emerged in response to this trend and is rapidly gaining traction in the fields of clinical oncology, cardiovascular medicine, inflammatory/infectious diseases, and pediatric diseases. In addition, the use of a growing number of radiopharmaceuticals in TB-PET/CT systems has shown promising results. Notably, the distinctive features of TB-PET/CT, such as its ultra-long axial field of view (194 cm), ultra-high sensitivity, and capability for low-dose tracer imaging, have enabled enhanced imaging quality while reducing the radiation dose. The envisioned whole-body dynamic imaging, delayed imaging, personalized disease management, and ultrafast acquisition for motion correction, among others, are achieved. This review highlights two key factors affecting molecular imaging, describing the rapid imaging effects of radiotracers allowed at low doses on TB-PET/CT and the improvements offered compared to conventional PET/CT.</p>","PeriodicalId":7572,"journal":{"name":"American journal of nuclear medicine and molecular imaging","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2023-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10656629/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138457236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Visualization of ferroptosis in brain diseases and ferroptosis-inducing nanomedicine for glioma. 脑疾病中铁下垂的可视化及诱导铁下垂的纳米药物治疗胶质瘤。
IF 2.5 Pub Date : 2023-10-20 eCollection Date: 2023-01-01
Chenyang Wang, Li Wen, Kun Wang, Ruolin Wu, Mengting Li, Yajing Zhang, Zairong Gao

A remarkable body of new data establishes that many degenerative brain diseases and some acute injury situations in the brain may be associated with ferroptosis. In recent years, ferroptosis has also attracted great interest in the cancer research community, partly because it is a unique mode of cell death distinct from other forms and thus has great therapeutic potential for brain cancer. Glioblastoma is a highly aggressive and fatal human cancer, accounting for 60% of all primary brain tumors. Despite the development of various pharmacological and surgical modalities, the survival rates of high-grade gliomas have remained poor over the past few decades. Recent evidence has revealed that ferroptosis is involved in tumor initiation, progression, and metastasis, and manipulating ferroptosis could offer a novel strategy for glioma management. Nanoparticles have been exploited as multifunctional platforms that can cross the blood-brain barrier and deliver therapeutic agents to the brain to address the pressing need for accurate visualization of ferroptosis and glioma treatment. To create efficient and durable ferroptosis inducers, many researchers have engineered nanocomposites to induce a more effective ferroptosis for therapy. In this review, we present the mechanism of ferroptosis and outline the current strategies of imaging and nanotherapy of ferroptosis in brain diseases, especially glioma. We aim to provide up-to-date information on ferroptosis and emphasize the potential clinical implications of ferroptosis for glioma diagnosis and treatment. However, regulation of ferroptosis in vivo remains challenging due to a lack of compounds.

大量的新数据表明,许多退行性脑疾病和一些急性脑损伤情况可能与铁下垂有关。近年来,铁下垂也引起了癌症研究界的极大兴趣,部分原因是它是一种不同于其他形式的独特细胞死亡模式,因此对脑癌具有很大的治疗潜力。胶质母细胞瘤是一种高度侵袭性和致命性的人类癌症,占所有原发性脑肿瘤的60%。尽管各种药物和手术方式的发展,在过去的几十年里,高级别胶质瘤的存活率仍然很低。最近的证据表明,铁下垂参与肿瘤的发生、发展和转移,操纵铁下垂可能为胶质瘤的治疗提供一种新的策略。纳米粒子已被开发为多功能平台,可以跨越血脑屏障,将治疗药物输送到大脑,以解决铁上吊和胶质瘤治疗的精确可视化的迫切需要。为了创造高效和持久的铁下垂诱导剂,许多研究人员设计了纳米复合材料来诱导更有效的铁下垂治疗。在这篇综述中,我们介绍了铁下垂的机制,并概述了目前脑疾病,特别是胶质瘤中铁下垂的成像和纳米治疗策略。我们的目的是提供有关铁下垂的最新信息,并强调铁下垂对胶质瘤诊断和治疗的潜在临床意义。然而,由于缺乏化合物,体内铁下垂的调节仍然具有挑战性。
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American journal of nuclear medicine and molecular imaging
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