Pub Date : 2021-01-01DOI: 10.1080/20905068.2021.1948157
O. Osuntokun, Mary Olabisi Aderoju, Ifeoluwa Esther Adebisi, T. Abayomi, Olorunfemi Samuel Tokunbo, G. Olayiwola
ABSTRACT Introduction The effects of chronic administration of phenytoin (PHT), levetiracetam (LEV), and PHT + LEV adjunctive treatments were examined on the cognitive functions of male rats. Methods Twenty-eight male Wistar rats (150–180 g) were randomized into 4 groups (N = 7). Groups I–IV received daily intraperitoneal administration of normal saline (0.2 ml), therapeutic doses of PHT (50 mg/kg), LEV (50 mg/kg) or sub-therapeutic dose of PHT (25 mg/kg) and LEV (25 mg/kg) combination, respectively, for 28 days. Thereafter, the animals were subjected to behavioral assessment and evaluation of the activities of acetylcholinesterase, lipid peroxidation, and lastly the morphological evaluation of the brain. Data were analyzed using descriptive and inferential statistics. The results were presented as mean ± SEM in graphs or tables, while the level of significance was taken at p < 0.05. Results Working & spatial memory, exploratory activities, and motor-coordination indices were significantly (p = 0.0099) impaired with a reduction in the frontal lobe and hippocampal weight following PHT and PHT + LEV adjunctive treatments. The frontal lobe and hippocampal activities of acetylcholinesterase increased significantly (p = 0.0437) following PHT and PHT + LEV adjunctive treatment. The concentrations of malondialdehyde increased significantly (p = 0.0473) in PHT, LEV, and PHT + LEV compared with the control. There was disorganization in the histoarchitectural profile with chromatolysis, hyalinization, and neural vacuolation in the pre-frontal cortex, hippocampus, and cerebellar tissue, especially in the PHT + LEV treated rats. Conclusion Impairment of cognitive functions following PHT and PHT + LEV adjunctive treatments may be attributable to the deregulation of cholinergic transmission and neurotoxicity.
{"title":"Phenytoin–levetiracetam adjunctive treatment-induced neurotoxicity and deregulation of cholinergic neurotransmission with evidence of neurocognitive impairment in male Wistar rats","authors":"O. Osuntokun, Mary Olabisi Aderoju, Ifeoluwa Esther Adebisi, T. Abayomi, Olorunfemi Samuel Tokunbo, G. Olayiwola","doi":"10.1080/20905068.2021.1948157","DOIUrl":"https://doi.org/10.1080/20905068.2021.1948157","url":null,"abstract":"ABSTRACT Introduction The effects of chronic administration of phenytoin (PHT), levetiracetam (LEV), and PHT + LEV adjunctive treatments were examined on the cognitive functions of male rats. Methods Twenty-eight male Wistar rats (150–180 g) were randomized into 4 groups (N = 7). Groups I–IV received daily intraperitoneal administration of normal saline (0.2 ml), therapeutic doses of PHT (50 mg/kg), LEV (50 mg/kg) or sub-therapeutic dose of PHT (25 mg/kg) and LEV (25 mg/kg) combination, respectively, for 28 days. Thereafter, the animals were subjected to behavioral assessment and evaluation of the activities of acetylcholinesterase, lipid peroxidation, and lastly the morphological evaluation of the brain. Data were analyzed using descriptive and inferential statistics. The results were presented as mean ± SEM in graphs or tables, while the level of significance was taken at p < 0.05. Results Working & spatial memory, exploratory activities, and motor-coordination indices were significantly (p = 0.0099) impaired with a reduction in the frontal lobe and hippocampal weight following PHT and PHT + LEV adjunctive treatments. The frontal lobe and hippocampal activities of acetylcholinesterase increased significantly (p = 0.0437) following PHT and PHT + LEV adjunctive treatment. The concentrations of malondialdehyde increased significantly (p = 0.0473) in PHT, LEV, and PHT + LEV compared with the control. There was disorganization in the histoarchitectural profile with chromatolysis, hyalinization, and neural vacuolation in the pre-frontal cortex, hippocampus, and cerebellar tissue, especially in the PHT + LEV treated rats. Conclusion Impairment of cognitive functions following PHT and PHT + LEV adjunctive treatments may be attributable to the deregulation of cholinergic transmission and neurotoxicity.","PeriodicalId":7611,"journal":{"name":"Alexandria Journal of Medicine","volume":"57 1","pages":"194 - 204"},"PeriodicalIF":0.9,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46886189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.1080/20905068.2020.1842086
R. Ammar, Emad A Areda, Ahmed Abd El Aziz El Abbady, Mina Wadieh Halim
ABSTRACT Background: Prevalence of diabetes in surgical patients is 10–40%. They have higher incidence of complications, and longer stay in hospital compared to non-diabetic. Radical cystectomy with urinary diversion is considered one of the high-risk surgeries associated with morbidity and mortality. Enhanced recovery after surgery (ERAS) is an evidence-based multimodal surgical care protocol that improves post-operative outcomes and length of stay (LOS) in patients without diabetes. This study evaluates the evidence on whether diabetic patientswould benefit from ERAS pathway. The aim of the study: was to evaluate the efficacy of ERAS protocol from anesthesia in diabetic patients undergoing radical cystectomy. Patients and methods: This study was carried out in Alexandria main University Hospital on fifty-four adult ASA physical status I, II and III participants of either sex. Participants were scheduled for radical cystectomy surgeries under the effect of general anesthesia, following ERAS protocol, divided into two group diabetic and non-diabetic27 participants each. The ICON device was used to measure the stroke volume variation (SVV) to apply goal-directed fluid therapy (GDFT) for all patients. Measurements: Demographic data, hemodynamic parameters (stoke volume, cardiac index), intra-operative fluid requirement, blood loss, postoperative pain intensity, time of first bowel movement, PH, Bicarbonate level, serum lactate level, heamatocrit and LOS were measured and recorded. Main results: No statistical significant difference was detected between both groups as regard age, sex, weight, vital signs, serum lactate, first bowel movement and VAS. There was statistical significant difference between both groups as regard fluid requirement, and the days of hospital stay. Conclusion: ERAS is a beneficial protocol to improve postoperative outcome in radical cystectomy surgeries, it can be used in diabetic patients to decrease postoperative morbidity and mortality.
{"title":"The efficacy of enhanced recovery protocol from anesthesia in diabetic patients undergoing radical cystectomy","authors":"R. Ammar, Emad A Areda, Ahmed Abd El Aziz El Abbady, Mina Wadieh Halim","doi":"10.1080/20905068.2020.1842086","DOIUrl":"https://doi.org/10.1080/20905068.2020.1842086","url":null,"abstract":"ABSTRACT Background: Prevalence of diabetes in surgical patients is 10–40%. They have higher incidence of complications, and longer stay in hospital compared to non-diabetic. Radical cystectomy with urinary diversion is considered one of the high-risk surgeries associated with morbidity and mortality. Enhanced recovery after surgery (ERAS) is an evidence-based multimodal surgical care protocol that improves post-operative outcomes and length of stay (LOS) in patients without diabetes. This study evaluates the evidence on whether diabetic patientswould benefit from ERAS pathway. The aim of the study: was to evaluate the efficacy of ERAS protocol from anesthesia in diabetic patients undergoing radical cystectomy. Patients and methods: This study was carried out in Alexandria main University Hospital on fifty-four adult ASA physical status I, II and III participants of either sex. Participants were scheduled for radical cystectomy surgeries under the effect of general anesthesia, following ERAS protocol, divided into two group diabetic and non-diabetic27 participants each. The ICON device was used to measure the stroke volume variation (SVV) to apply goal-directed fluid therapy (GDFT) for all patients. Measurements: Demographic data, hemodynamic parameters (stoke volume, cardiac index), intra-operative fluid requirement, blood loss, postoperative pain intensity, time of first bowel movement, PH, Bicarbonate level, serum lactate level, heamatocrit and LOS were measured and recorded. Main results: No statistical significant difference was detected between both groups as regard age, sex, weight, vital signs, serum lactate, first bowel movement and VAS. There was statistical significant difference between both groups as regard fluid requirement, and the days of hospital stay. Conclusion: ERAS is a beneficial protocol to improve postoperative outcome in radical cystectomy surgeries, it can be used in diabetic patients to decrease postoperative morbidity and mortality.","PeriodicalId":7611,"journal":{"name":"Alexandria Journal of Medicine","volume":"57 1","pages":"38 - 43"},"PeriodicalIF":0.9,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/20905068.2020.1842086","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45985425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.1080/20905068.2021.1876288
N. El-Kafrawy, Azza EL-Bastawisy M Atta, S. Abdelsattar, S. Zewain
ABSTRACT Background Obesity is a major health problem with increasing prevalence and directly contributes to the development of cardiovascular disease (CVD). Selenoprotein P (Se P) is a novel hepatokine that affects glucose metabolism, lipid metabolism, and correlating with insulin resistance, inflammation, and atherosclerosis. Plasma Se P level is one of the promising biomarkers for predictions or diagnoses/prognoses of the diseases. Objective Evaluating the serum level of Selenoprotein P in overweight, obese, and lean individuals and its relation to insulin resistance and cardiometabolic parameters. Subjects and Methods A cross-sectional study was conducted in the Outpatient Endocrinology Clinics, Internal Medicine Department, Menoufia University Hospitals on 90 individuals that were divided into two groups: (group I) 50 overweight and obese individuals (with body mass index (BMI) in the range 25.0–29.9 kg/m2 and ≥30.0 kg/m2, respectively) and (group II) 40 lean individuals with BMI in the range (18.5–24.9) kg/m2. All subjects were subjected to detailed history taking, clinical examination, and laboratory investigations including fasting and 2 hours postprandial blood sugar, lipid profile, fasting serum insulin level, Homeostatic Model Assessment of Insulin Resistance (HOMA-IR), and serum Se P. Results Se P concentrations were significantly increased in overweight and obese group than lean group (p < 0.001). Se P concentration was related to various cardio-metabolic parameters. In overweight and obese group there was a significant positive correlation between serum Selenoprotein p level and waist circumference (WC) (r −0.453, p <0.001), hip circumference (HC) (r = 0.464, p < 0.001), waist-hip ratio (WHR) (r −0.506, p < 0.001), visceral adiposity index (VAI) (r = 0.323, p = 0.022), fasting serum insulin (r = 0.585, p < 0.001), and HOMA-IR (r = 0.570, p < 0.001). Conclusion Circulating Se P concentrations is elevated in obesity and related to insulin resistance, visceral adiposity, and atherogenic index of plasma.
背景肥胖是一个主要的健康问题，其患病率越来越高，并直接导致心血管疾病(CVD)的发展。硒蛋白P(硒蛋白P)是一种影响糖代谢、脂质代谢的新型肝因子，与胰岛素抵抗、炎症和动脉粥样硬化相关。血浆硒磷水平是预测或诊断/预后的有前途的生物标志物之一。目的探讨超重、肥胖和瘦弱人群血清硒蛋白P水平及其与胰岛素抵抗和心脏代谢参数的关系。研究对象与方法:在梅努菲亚大学附属医院内科内分泌门诊对90例患者进行横断面研究，将90例患者分为两组:(1)体重指数(BMI)分别为25.0 ~ 29.9 kg/m2和≥30.0 kg/m2的超重和肥胖患者50例;(2)体重指数(BMI)为(18.5 ~ 24.9)kg/m2的消瘦患者40例。所有受试者均接受详细的病史记录、临床检查和实验室调查，包括空腹和餐后2小时血糖、血脂、空腹血清胰岛素水平、胰岛素抵抗稳态模型评估(HOMA-IR)和血清硒磷。结果超重和肥胖组硒磷浓度显著高于瘦组(P < 0.001)。硒磷浓度与各种心脏代谢参数有关。超重和肥胖组血清硒蛋白p水平与腰围(WC) (r−0.453,p <0.001)、臀围(r = 0.464, p <0.001)、腰臀比(WHR) (r−0.506,p <0.001)、内脏脂肪指数(VAI) (r = 0.323, p = 0.022)、空腹血清胰岛素(r = 0.585, p <0.001)、HOMA-IR (r = 0.570, p <0.001)呈显著正相关。结论肥胖患者血硒磷浓度升高，与胰岛素抵抗、内脏肥胖和血浆动脉粥样硬化指数有关。
{"title":"Serum selenoprotein P in lean and obese Egyptian individuals and its relation to insulin resistance","authors":"N. El-Kafrawy, Azza EL-Bastawisy M Atta, S. Abdelsattar, S. Zewain","doi":"10.1080/20905068.2021.1876288","DOIUrl":"https://doi.org/10.1080/20905068.2021.1876288","url":null,"abstract":"ABSTRACT Background Obesity is a major health problem with increasing prevalence and directly contributes to the development of cardiovascular disease (CVD). Selenoprotein P (Se P) is a novel hepatokine that affects glucose metabolism, lipid metabolism, and correlating with insulin resistance, inflammation, and atherosclerosis. Plasma Se P level is one of the promising biomarkers for predictions or diagnoses/prognoses of the diseases. Objective Evaluating the serum level of Selenoprotein P in overweight, obese, and lean individuals and its relation to insulin resistance and cardiometabolic parameters. Subjects and Methods A cross-sectional study was conducted in the Outpatient Endocrinology Clinics, Internal Medicine Department, Menoufia University Hospitals on 90 individuals that were divided into two groups: (group I) 50 overweight and obese individuals (with body mass index (BMI) in the range 25.0–29.9 kg/m2 and ≥30.0 kg/m2, respectively) and (group II) 40 lean individuals with BMI in the range (18.5–24.9) kg/m2. All subjects were subjected to detailed history taking, clinical examination, and laboratory investigations including fasting and 2 hours postprandial blood sugar, lipid profile, fasting serum insulin level, Homeostatic Model Assessment of Insulin Resistance (HOMA-IR), and serum Se P. Results Se P concentrations were significantly increased in overweight and obese group than lean group (p < 0.001). Se P concentration was related to various cardio-metabolic parameters. In overweight and obese group there was a significant positive correlation between serum Selenoprotein p level and waist circumference (WC) (r −0.453, p <0.001), hip circumference (HC) (r = 0.464, p < 0.001), waist-hip ratio (WHR) (r −0.506, p < 0.001), visceral adiposity index (VAI) (r = 0.323, p = 0.022), fasting serum insulin (r = 0.585, p < 0.001), and HOMA-IR (r = 0.570, p < 0.001). Conclusion Circulating Se P concentrations is elevated in obesity and related to insulin resistance, visceral adiposity, and atherogenic index of plasma.","PeriodicalId":7611,"journal":{"name":"Alexandria Journal of Medicine","volume":"57 1","pages":"61 - 69"},"PeriodicalIF":0.9,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/20905068.2021.1876288","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44598606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.1080/20905068.2020.1871179
H. Mohamed, M. Shenouda
ABSTRACT Background: Aminoglycosides, particularly gentamicin, endure crucial antibiotics in the armamentarium for severe Gram-negative bacterial infections through their significant risk for nephrotoxicity. Co-administration of several applicant nephroprotective agents has been investigated at the preclinical level. Garlic was proved to be an oxidative stress combatant with unique antioxidant potential. Aim of the work: To assess renal cortex structural changes due to gentamicin treatment and the role of the aqueous garlic extract (AGE) in ameliorating these changes. Material and methods: Thirty-two male albino rats were assigned into four equal groups. Group I (Control group) received 0.9% NaCl solution through oral gavage in the same volume as in AGE-treated group. Group II (AGE treated group) received AGE by oral gavage at 250 mg/kg/day. Group III (Gentamicin treated group) received Gentamicin at 80 mg/kg/day intraperitoneally. Group IV (Gentamicin and AGE cotreated group) received both gentamicin and AGE. The duration of the treatment was 21 days. Specimens of renal cortex of all groups were processed for light microscopic examination. Specimens were additionally prepared for electron microscopic examination. Morphometric study and statistical analysis were performed. Results: Examination of the renal cortex in the gentamicin treated rats showed both proximal and distal tubular necrosis, vacuolation, desquamation and interstitial mononuclear cell infiltration. Masson’s trichrome staining revealed intense deposition of collagen fibers. Strong positive immunoreaction for caspase-3 was observed. Ultrastructurally, the glomerulus showed thickened basement membrane, destructed endothelium. Proximal and distal convoluted tubular cells exhibited vacuolations, distorted mitochondria and nuclear chromatin condensation with loss of microvilli. AGE ameliorated these changes. Conclusion: Aqueous garlic extract ameliorates the histological changes caused by gentamicin in the rat renal cortex.
{"title":"Amelioration of renal cortex histological alterations by aqueous garlic extract in gentamicin induced renal toxicity in albino rats: a histological and immunohistochemical study","authors":"H. Mohamed, M. Shenouda","doi":"10.1080/20905068.2020.1871179","DOIUrl":"https://doi.org/10.1080/20905068.2020.1871179","url":null,"abstract":"ABSTRACT Background: Aminoglycosides, particularly gentamicin, endure crucial antibiotics in the armamentarium for severe Gram-negative bacterial infections through their significant risk for nephrotoxicity. Co-administration of several applicant nephroprotective agents has been investigated at the preclinical level. Garlic was proved to be an oxidative stress combatant with unique antioxidant potential. Aim of the work: To assess renal cortex structural changes due to gentamicin treatment and the role of the aqueous garlic extract (AGE) in ameliorating these changes. Material and methods: Thirty-two male albino rats were assigned into four equal groups. Group I (Control group) received 0.9% NaCl solution through oral gavage in the same volume as in AGE-treated group. Group II (AGE treated group) received AGE by oral gavage at 250 mg/kg/day. Group III (Gentamicin treated group) received Gentamicin at 80 mg/kg/day intraperitoneally. Group IV (Gentamicin and AGE cotreated group) received both gentamicin and AGE. The duration of the treatment was 21 days. Specimens of renal cortex of all groups were processed for light microscopic examination. Specimens were additionally prepared for electron microscopic examination. Morphometric study and statistical analysis were performed. Results: Examination of the renal cortex in the gentamicin treated rats showed both proximal and distal tubular necrosis, vacuolation, desquamation and interstitial mononuclear cell infiltration. Masson’s trichrome staining revealed intense deposition of collagen fibers. Strong positive immunoreaction for caspase-3 was observed. Ultrastructurally, the glomerulus showed thickened basement membrane, destructed endothelium. Proximal and distal convoluted tubular cells exhibited vacuolations, distorted mitochondria and nuclear chromatin condensation with loss of microvilli. AGE ameliorated these changes. Conclusion: Aqueous garlic extract ameliorates the histological changes caused by gentamicin in the rat renal cortex.","PeriodicalId":7611,"journal":{"name":"Alexandria Journal of Medicine","volume":"57 1","pages":"28 - 37"},"PeriodicalIF":0.9,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/20905068.2020.1871179","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47383165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.1080/20905068.2021.1913890
Kolawole Oluseyi Akande, T. Oke, O. Afuwape, T. Adigun, A. Akere, Ajibola Aje, S. Ola, J. Otegbayo
ABSTRACT Introduction: Dyspepsia is a symptom complex with varied underlying etiologies. The underlying etiology determines the precise treatment and prognosis though Helicobacter pylori infection plays a central role. The aim of this study was to describe the spectrum and pattern of distribution of findings in patients with dyspepsia undergoing oesophago-gastro-duodenoscopy at the University College Hospital, Ibadan. Methods: A retrospective analysis of computerized database patients with dyspepsia who underwent oesophago-gastro–duodenoscopy from 2015 to 2019. Results: A total of 1,373 procedures were done and dyspepsia was the indication in 736 (53.2%) comprising 317 (43.1%) male and 405 (55%) female (P< .001). The age ranged from 18 to 100 with a mean of 50 ± 15 years. The age group 40–59 years had the highest representation (P = .00). The esophageal mucosa was normal in 592 (80.4%) while 45 (6.1%) and 36 (4.9%) patients had esophagitis and esophageal candidiasis, respectively. In the stomach, 230 (31%) patients had normal mucosa while 433 (57.5%) and 40 (5.4%) patients had gastritis and gastric ulcers, respectively. Antrum was the most commonly involved site by the gastritis and ulcers in 236 (55.8%) and 24 (60%) patients, respectively. The mean age of those with non-ulcer dyspepsia was 49.8 ± 15 while that of those with organic dyspepsia was 55.7 ± 13.7 years (P= .01). Furthermore, there was a significant correlation between the age group and organic dyspepsia (P = .00). The first part of the duodenum was normal in 594 (80.7%) while bulbar duodenitis was seen in 106 (14.4%). Conclusion: In our practice, OGD in patients with dyspepsia is either normal or yielded few abnormalities. The most common abnormalities were gastritis, duodenitis, esophagitis and gastric ulcers. Gastritis and ulcers were antral predominant and gastric ulcers were more common than duodenal ulcers. There was a significant relationship between increasing age and organic dyspepsia.
{"title":"Spectrum and pattern of distribution of findings in patients with dyspepsia undergoing oesophago-gastro-duodenoscopy at a Tertiary Hospital in Ibadan, south west, Nigeria","authors":"Kolawole Oluseyi Akande, T. Oke, O. Afuwape, T. Adigun, A. Akere, Ajibola Aje, S. Ola, J. Otegbayo","doi":"10.1080/20905068.2021.1913890","DOIUrl":"https://doi.org/10.1080/20905068.2021.1913890","url":null,"abstract":"ABSTRACT Introduction: Dyspepsia is a symptom complex with varied underlying etiologies. The underlying etiology determines the precise treatment and prognosis though Helicobacter pylori infection plays a central role. The aim of this study was to describe the spectrum and pattern of distribution of findings in patients with dyspepsia undergoing oesophago-gastro-duodenoscopy at the University College Hospital, Ibadan. Methods: A retrospective analysis of computerized database patients with dyspepsia who underwent oesophago-gastro–duodenoscopy from 2015 to 2019. Results: A total of 1,373 procedures were done and dyspepsia was the indication in 736 (53.2%) comprising 317 (43.1%) male and 405 (55%) female (P< .001). The age ranged from 18 to 100 with a mean of 50 ± 15 years. The age group 40–59 years had the highest representation (P = .00). The esophageal mucosa was normal in 592 (80.4%) while 45 (6.1%) and 36 (4.9%) patients had esophagitis and esophageal candidiasis, respectively. In the stomach, 230 (31%) patients had normal mucosa while 433 (57.5%) and 40 (5.4%) patients had gastritis and gastric ulcers, respectively. Antrum was the most commonly involved site by the gastritis and ulcers in 236 (55.8%) and 24 (60%) patients, respectively. The mean age of those with non-ulcer dyspepsia was 49.8 ± 15 while that of those with organic dyspepsia was 55.7 ± 13.7 years (P= .01). Furthermore, there was a significant correlation between the age group and organic dyspepsia (P = .00). The first part of the duodenum was normal in 594 (80.7%) while bulbar duodenitis was seen in 106 (14.4%). Conclusion: In our practice, OGD in patients with dyspepsia is either normal or yielded few abnormalities. The most common abnormalities were gastritis, duodenitis, esophagitis and gastric ulcers. Gastritis and ulcers were antral predominant and gastric ulcers were more common than duodenal ulcers. There was a significant relationship between increasing age and organic dyspepsia.","PeriodicalId":7611,"journal":{"name":"Alexandria Journal of Medicine","volume":"57 1","pages":"151 - 156"},"PeriodicalIF":0.9,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/20905068.2021.1913890","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46085732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.1080/20905068.2021.1907961
Ayman M. Elbadawy, Rasha O. Abd Elmoniem, A. Elsayed
ABSTRACT Introduction: Alpha lipoic acid (ALA) is an antioxidant used in the treatment of neuro-inflammation, diabetes and diabetic nephropathy. The current study aiming to gauge the effect of oral ALA on diabetic peripheral neuropathy, glycemic control, LDL-C, and HDL-C. Methods: This is a prospective, interventional study carried out on patients with type 2 diabetes mellitus (DM) who were following at the outpatient internal medicine & diabetes clinics at Benha University Hospital. Treatment with ALA for 3 months was given to patient with diabetic peripheral neuropathy. Data in the form of age, sex, body mass index (BMI), duration & treatment of DM, manifestations of peripheral neuropathy were collected. LDL-C, HDL-C, HbA1c, TSH, ALT, AST were measured before and after intervention. Peripheral neuropathy symptoms, nerve conduction velocities, cardiovascular (CV) tests of autonomic neuropathy, and cross-section area of the posterior tibial nerve were performed before and after treatment intervention. Results: 90 adult diabetic patients were recruited in the study, 42.2% were females and 57.8% were males with a median age of 50–60.3 years (IQR = 52). A statistically significant improvements of neuropathic symptoms, nerve conduction velocity, and cardiovascular autonomic neuropathy were noted after 3 months of administration of ALA (p ˂0.001). However, the cross-section area of the posterior tibial nerve at baseline and after treatment did not change significantly (p value of 0.84). There was a significant improvement in the BMI, HDL-C, LDL-C, HbA1c (p ˂ 0.001). Conclusion: Oral treatment with ALA might cause ameliorations of peripheral neuropathy, HbA1c, and LDL-C & HDL-C levels in diabetic patients. Our result failed to proof effect of ALA on nerve cross-section area. The global data encourage further studies with this medication as an ancillary treatment of DM2. Clinical trial registration: It was registered in clinical trial website; ClinicalTrials.gov Identifier (NCT number): NCT04322240.
{"title":"Alpha lipoic acid and diabetes mellitus: potential effects on peripheral neuropathy and different metabolic parameters","authors":"Ayman M. Elbadawy, Rasha O. Abd Elmoniem, A. Elsayed","doi":"10.1080/20905068.2021.1907961","DOIUrl":"https://doi.org/10.1080/20905068.2021.1907961","url":null,"abstract":"ABSTRACT Introduction: Alpha lipoic acid (ALA) is an antioxidant used in the treatment of neuro-inflammation, diabetes and diabetic nephropathy. The current study aiming to gauge the effect of oral ALA on diabetic peripheral neuropathy, glycemic control, LDL-C, and HDL-C. Methods: This is a prospective, interventional study carried out on patients with type 2 diabetes mellitus (DM) who were following at the outpatient internal medicine & diabetes clinics at Benha University Hospital. Treatment with ALA for 3 months was given to patient with diabetic peripheral neuropathy. Data in the form of age, sex, body mass index (BMI), duration & treatment of DM, manifestations of peripheral neuropathy were collected. LDL-C, HDL-C, HbA1c, TSH, ALT, AST were measured before and after intervention. Peripheral neuropathy symptoms, nerve conduction velocities, cardiovascular (CV) tests of autonomic neuropathy, and cross-section area of the posterior tibial nerve were performed before and after treatment intervention. Results: 90 adult diabetic patients were recruited in the study, 42.2% were females and 57.8% were males with a median age of 50–60.3 years (IQR = 52). A statistically significant improvements of neuropathic symptoms, nerve conduction velocity, and cardiovascular autonomic neuropathy were noted after 3 months of administration of ALA (p ˂0.001). However, the cross-section area of the posterior tibial nerve at baseline and after treatment did not change significantly (p value of 0.84). There was a significant improvement in the BMI, HDL-C, LDL-C, HbA1c (p ˂ 0.001). Conclusion: Oral treatment with ALA might cause ameliorations of peripheral neuropathy, HbA1c, and LDL-C & HDL-C levels in diabetic patients. Our result failed to proof effect of ALA on nerve cross-section area. The global data encourage further studies with this medication as an ancillary treatment of DM2. Clinical trial registration: It was registered in clinical trial website; ClinicalTrials.gov Identifier (NCT number): NCT04322240.","PeriodicalId":7611,"journal":{"name":"Alexandria Journal of Medicine","volume":"57 1","pages":"113 - 120"},"PeriodicalIF":0.9,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/20905068.2021.1907961","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47250023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.1080/20905068.2021.1987795
A. Kamel, Eman Adel Hassanin Sherif, Waleed Khaled. El Zawawy, Nashwa Ahmed El-shinawy
ABSTRACT Back ground: Pulmonary fibrosis is an irreversible disease with excessive scarring and fibrosis of lung tissue. Glucocorticoid therapy of dexamethasone attenuates lung inflammation with severe adverse effects. Subsequently, synthesizing Nano chitosan from chitosan macromolecule and loading dexamethasone onto Nano chitosan particles have shown improved pharmacokinetics of dexamethasone. Purpose: The aim of this study was to prepare and characterize dexamethasone Nano chitosan particles chemically and then to evaluate the effectiveness of loading dexamethasone onto Nano chitosan as a treatment of pulmonary injury induced by bleomycin-induced in C57BL/6 mice. Results: This study elucidated significant elevations of serum malondialdehyde and lactate dehydrogenase with an increased lung tissue inflammatory mediators, collagen profile, Caspase-3, and MUC5AC gene expressions. This was accompanied by a significant elevation in total and differential leukocyte counts in bronchoalveolar lavage fluid. Besides, there were recognized histological and histopathological alterations in lung tissue sections following both 14 and 28 days of bleomycin instillation. Consequently, treatment of lung injury by dexamethasone alone or dexamethasone loaded onto Nano chitosan particles revealed a significant reduction of MDA and LDH, a decline in lung tissue inflammatory mediators, collagen profile, Caspase-3, and MUC5AC gene expressions. This was accompanied by a significant reduction in total and differential leukocyte counts in bronchoalveolar lavage fluid. However, loading dexamethasone onto Nano chitosan provided novel insights in pulmonary injury treatment
{"title":"Therapeutic potential of dexamethasone Nano chitosan synthesized from chitosan as a novel treatment of pulmonary fibrosis in C57BL/6 mice","authors":"A. Kamel, Eman Adel Hassanin Sherif, Waleed Khaled. El Zawawy, Nashwa Ahmed El-shinawy","doi":"10.1080/20905068.2021.1987795","DOIUrl":"https://doi.org/10.1080/20905068.2021.1987795","url":null,"abstract":"ABSTRACT Back ground: Pulmonary fibrosis is an irreversible disease with excessive scarring and fibrosis of lung tissue. Glucocorticoid therapy of dexamethasone attenuates lung inflammation with severe adverse effects. Subsequently, synthesizing Nano chitosan from chitosan macromolecule and loading dexamethasone onto Nano chitosan particles have shown improved pharmacokinetics of dexamethasone. Purpose: The aim of this study was to prepare and characterize dexamethasone Nano chitosan particles chemically and then to evaluate the effectiveness of loading dexamethasone onto Nano chitosan as a treatment of pulmonary injury induced by bleomycin-induced in C57BL/6 mice. Results: This study elucidated significant elevations of serum malondialdehyde and lactate dehydrogenase with an increased lung tissue inflammatory mediators, collagen profile, Caspase-3, and MUC5AC gene expressions. This was accompanied by a significant elevation in total and differential leukocyte counts in bronchoalveolar lavage fluid. Besides, there were recognized histological and histopathological alterations in lung tissue sections following both 14 and 28 days of bleomycin instillation. Consequently, treatment of lung injury by dexamethasone alone or dexamethasone loaded onto Nano chitosan particles revealed a significant reduction of MDA and LDH, a decline in lung tissue inflammatory mediators, collagen profile, Caspase-3, and MUC5AC gene expressions. This was accompanied by a significant reduction in total and differential leukocyte counts in bronchoalveolar lavage fluid. However, loading dexamethasone onto Nano chitosan provided novel insights in pulmonary injury treatment","PeriodicalId":7611,"journal":{"name":"Alexandria Journal of Medicine","volume":"57 1","pages":"247 - 259"},"PeriodicalIF":0.9,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48049585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.1080/20905068.2021.1954413
Fatma Alzahraa Abdelsalam Elkhamisy, R. Wassef
ABSTRACT Introduction: Pathology learning for medical undergraduate students is a challenging task. Kahoot! is a mobile game-based online digital formative assessment tool that can engage students in its learning. This study is the first to assess the effect of Kahoot! use on Pathology learning outside classroom using a comparative group with assessment done at the end of the course. Methods: The study was carried out on the first-year Pathology students at Helwan University, Faculty of Medicine, after ending a basic Pathology course. The study is a retrospective quasi-experimental quantitative study. Academic performance of students in Pathology was compared between Kahoot! and non-Kahoot! users (55 students each). In addition, an online survey was introduced to the 55 Kahoot! user students to investigate their perceptions on it. Survey and test score data were analyzed by appropriate tests using IBM-SPSS (Statistical Package for Social Sciences). The level of significance was P < 0.05. Results: Kahoot! enhanced Pathology understanding (83.6%), retaining knowledge (87.3%), made learning fun and motivating (89.1%). Other mentioned advantages of Kahoot! were practicing for exam (40%), simple and easy to use (36.4%), competitive (18.2%), self confidence booster (10.9%), forming a comprehensive image of the lecture (9%), quick (9%), and imagining skills booster (5.5%). Mentioned disadvantages included no explanation for the answers to questions (20%). A quarter of the students stated that the time limit for the questions was short (27.3%). Kahoot! use was significantly associated with better Pathology academic performance (P = 0.001), and it was not related to the general academic performance of the students (P = 0.06). Most users (85.4%) recommended its continuous future use. Conclusions: The study offers an endorsement to the use of Kahoot! for gamifying formative assessment of Pathology and can provide a basis for the design of an online Kahoot! -based continuous formative assessment plans implemented outside-classroom in the Pathology curricula.
摘要导读:医学本科学生的病理学学习是一项具有挑战性的任务。Kahoot !是一个基于移动游戏的在线数字形成性评估工具，可以让学生参与学习。这项研究首次评估了Kahoot!在病理学课堂外的学习中使用比较组，并在课程结束时进行评估。方法:以河南大学医学院病理学专业一年级学生为研究对象，在病理学基础课程结束后进行研究。本研究为回顾性准实验定量研究。比较了Kahoot!和non-Kahoot !用户(每人55名学生)。此外，一项在线调查被引入到55 Kahoot!用户学生调查他们对它的看法。采用IBM-SPSS (Statistical Package for Social Sciences)软件对调查和考试成绩数据进行分析。显著性水平P < 0.05。结果:Kahoot !提高病理理解(83.6%)，保留知识(87.3%)，使学习变得有趣和激励(89.1%)。其他提到的优点。分别为考试练习(40%)、简单易用(36.4%)、好胜(18.2%)、自信提升(10.9%)、形成讲座综合形象(9%)、快速(9%)、想象技能提升(5.5%)。提到的缺点包括对问题的答案没有解释(20%)。四分之一的学生(27.3%)表示问题的时间限制很短。Kahoot !使用与病理学学习成绩显著相关(P = 0.001)，与学生的一般学习成绩无关(P = 0.06)。大多数用户(85.4%)建议今后继续使用。结论:本研究为使用Kahoot!游戏化病理学的形成性评估，并可以为在线Kahoot的设计提供基础!在病理学课程的课堂外实施基于基础的持续形成性评估计划。
{"title":"Innovating pathology learning via Kahoot! game-based tool: a quantitative study of students` perceptions and academic performance","authors":"Fatma Alzahraa Abdelsalam Elkhamisy, R. Wassef","doi":"10.1080/20905068.2021.1954413","DOIUrl":"https://doi.org/10.1080/20905068.2021.1954413","url":null,"abstract":"ABSTRACT Introduction: Pathology learning for medical undergraduate students is a challenging task. Kahoot! is a mobile game-based online digital formative assessment tool that can engage students in its learning. This study is the first to assess the effect of Kahoot! use on Pathology learning outside classroom using a comparative group with assessment done at the end of the course. Methods: The study was carried out on the first-year Pathology students at Helwan University, Faculty of Medicine, after ending a basic Pathology course. The study is a retrospective quasi-experimental quantitative study. Academic performance of students in Pathology was compared between Kahoot! and non-Kahoot! users (55 students each). In addition, an online survey was introduced to the 55 Kahoot! user students to investigate their perceptions on it. Survey and test score data were analyzed by appropriate tests using IBM-SPSS (Statistical Package for Social Sciences). The level of significance was P < 0.05. Results: Kahoot! enhanced Pathology understanding (83.6%), retaining knowledge (87.3%), made learning fun and motivating (89.1%). Other mentioned advantages of Kahoot! were practicing for exam (40%), simple and easy to use (36.4%), competitive (18.2%), self confidence booster (10.9%), forming a comprehensive image of the lecture (9%), quick (9%), and imagining skills booster (5.5%). Mentioned disadvantages included no explanation for the answers to questions (20%). A quarter of the students stated that the time limit for the questions was short (27.3%). Kahoot! use was significantly associated with better Pathology academic performance (P = 0.001), and it was not related to the general academic performance of the students (P = 0.06). Most users (85.4%) recommended its continuous future use. Conclusions: The study offers an endorsement to the use of Kahoot! for gamifying formative assessment of Pathology and can provide a basis for the design of an online Kahoot! -based continuous formative assessment plans implemented outside-classroom in the Pathology curricula.","PeriodicalId":7611,"journal":{"name":"Alexandria Journal of Medicine","volume":"57 1","pages":"215 - 223"},"PeriodicalIF":0.9,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/20905068.2021.1954413","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42012718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.1080/20905068.2021.1874626
C. E. Chukwu, O. Ebuehi, J. Ajuluchukwu, Adedeji H. S. Olashore
ABSTRACT Background Hypertension is a major modifiable risk factor for cardiovascular diseases and all-cause death globally and in Africa. The prevalence of hypertension in Nigeria is 28.9%. In Nigeria, analytical studies to determine risk factors and potential biomarkers of hypertension are lacking. This study was conducted to determine lifestyle, anthropometric, socio-demographic, and biochemical risk factors associated with hypertension in Lagos, Nigeria. Method This case–control study was conducted among 410 participants, aged 18–65 years. A well-structured questionnaire was used to collect data from cases and controls. Anthropometric and blood pressure measurements were taken. Blood samples were also collected for biochemical analysis. Logistic regression analysis was used to determine risk factors associated with hypertension. Data obtained were analyzed using SPSS version 25.0. P-value less than 0.05 was considered statistically significant. Result In total, 205 hypertensive cases and 205 normotensive controls were recruited. The mean ± SD age of the participants was 39.25 ± 11.49 years. Overall, 180 (44%) of participants were female. Logistic regression analysis indicated that obesity (OR = 3.324, 95% CI = 1.693–6.527, P= 0.000), family history (OR = 2.861, 95% CI = 1.731–4.729, P= 0.000), hypercholesterolemia (OR = 2.940, 95% CI = 1.577–5.480, P= 0.001), insufficient fruits and vegetables intake (OR = 0.152, 95% CI = 0.085–0.273, P= 0.000), frequent intake of dietary salt (OR = 0.400, 95% CI = 0.198–0.810, P= 0.011), and smoking status (OR = 3.709, 95% CI = 1.061–12.964, P= 0.040) were significantly associated with hypertension. Conclusion Population-based approaches to reduce exposure to hypertension risk factors are required for effective prevention and control of hypertension and cardiovascular diseases in Lagos, Nigeria.
{"title":"Anthropometric, socio-demographic and biochemical risk factors of hypertension in Lagos, Nigeria","authors":"C. E. Chukwu, O. Ebuehi, J. Ajuluchukwu, Adedeji H. S. Olashore","doi":"10.1080/20905068.2021.1874626","DOIUrl":"https://doi.org/10.1080/20905068.2021.1874626","url":null,"abstract":"ABSTRACT Background Hypertension is a major modifiable risk factor for cardiovascular diseases and all-cause death globally and in Africa. The prevalence of hypertension in Nigeria is 28.9%. In Nigeria, analytical studies to determine risk factors and potential biomarkers of hypertension are lacking. This study was conducted to determine lifestyle, anthropometric, socio-demographic, and biochemical risk factors associated with hypertension in Lagos, Nigeria. Method This case–control study was conducted among 410 participants, aged 18–65 years. A well-structured questionnaire was used to collect data from cases and controls. Anthropometric and blood pressure measurements were taken. Blood samples were also collected for biochemical analysis. Logistic regression analysis was used to determine risk factors associated with hypertension. Data obtained were analyzed using SPSS version 25.0. P-value less than 0.05 was considered statistically significant. Result In total, 205 hypertensive cases and 205 normotensive controls were recruited. The mean ± SD age of the participants was 39.25 ± 11.49 years. Overall, 180 (44%) of participants were female. Logistic regression analysis indicated that obesity (OR = 3.324, 95% CI = 1.693–6.527, P= 0.000), family history (OR = 2.861, 95% CI = 1.731–4.729, P= 0.000), hypercholesterolemia (OR = 2.940, 95% CI = 1.577–5.480, P= 0.001), insufficient fruits and vegetables intake (OR = 0.152, 95% CI = 0.085–0.273, P= 0.000), frequent intake of dietary salt (OR = 0.400, 95% CI = 0.198–0.810, P= 0.011), and smoking status (OR = 3.709, 95% CI = 1.061–12.964, P= 0.040) were significantly associated with hypertension. Conclusion Population-based approaches to reduce exposure to hypertension risk factors are required for effective prevention and control of hypertension and cardiovascular diseases in Lagos, Nigeria.","PeriodicalId":7611,"journal":{"name":"Alexandria Journal of Medicine","volume":"57 1","pages":"44 - 51"},"PeriodicalIF":0.9,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/20905068.2021.1874626","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46014812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.1080/20905068.2021.1884333
N. Mahmoud, R. Gomaa, A. Salem
ABSTRACT Introduction: Cell phones are essential for modern life and their usage becomes prevalent. Worries have increased concerning the harmful effects of their radio-frequency electromagnetic radiation. Liver X receptors (LXRs) are ligand-dependent transcription factors that have important roles in lipid metabolism and inflammation, plus several recently emerging roles. Whether it is useful to overcome the hazardous effects of cell phone radiation needs to be clarified. So, this study aimed to investigate the effect of LXRs activation on testicular changes in rats exposed to electromagnetic radiation. Methods: Thirty adult male Wistar rats were subdivided into control group, experimental group: exposed to cell phone electromagnetic radiation, and treated group: as experimental group and received LXRs agonist T0901317. Serum testosterone (T), Follicle-Stimulating Hormone (FSH), and Luteinizing Hormone (LH), testicular tissue malondialdehyde (MDA) and superoxide dismutase (SOD), and gene expressions of inflammatory and apoptotic markers were assessed. Seminal analysis and testicular histological examination were performed. Results: LXRs activation in rats exposed to cell phone radiation improved the decreased testicular and gonadotrophic hormones, semen quality parameters, tissue SOD, and anti-apoptotic gene expression as well as the elevated tissue MDA, apoptotic and inflammatory gene expressions, and the testicular histological changes induced by exposure to electromagnetic radiation. Conclusion: Exposure to cell phone radiation leads to harmful effects on spermatogenesis and LXRs activation could improve these effects via antioxidant, anti-inflammatory properties in addition to its endocrinal action.
{"title":"Activation of liver X receptors ameliorates alterations in testicular function in rats exposed to electromagnetic radiation","authors":"N. Mahmoud, R. Gomaa, A. Salem","doi":"10.1080/20905068.2021.1884333","DOIUrl":"https://doi.org/10.1080/20905068.2021.1884333","url":null,"abstract":"ABSTRACT Introduction: Cell phones are essential for modern life and their usage becomes prevalent. Worries have increased concerning the harmful effects of their radio-frequency electromagnetic radiation. Liver X receptors (LXRs) are ligand-dependent transcription factors that have important roles in lipid metabolism and inflammation, plus several recently emerging roles. Whether it is useful to overcome the hazardous effects of cell phone radiation needs to be clarified. So, this study aimed to investigate the effect of LXRs activation on testicular changes in rats exposed to electromagnetic radiation. Methods: Thirty adult male Wistar rats were subdivided into control group, experimental group: exposed to cell phone electromagnetic radiation, and treated group: as experimental group and received LXRs agonist T0901317. Serum testosterone (T), Follicle-Stimulating Hormone (FSH), and Luteinizing Hormone (LH), testicular tissue malondialdehyde (MDA) and superoxide dismutase (SOD), and gene expressions of inflammatory and apoptotic markers were assessed. Seminal analysis and testicular histological examination were performed. Results: LXRs activation in rats exposed to cell phone radiation improved the decreased testicular and gonadotrophic hormones, semen quality parameters, tissue SOD, and anti-apoptotic gene expression as well as the elevated tissue MDA, apoptotic and inflammatory gene expressions, and the testicular histological changes induced by exposure to electromagnetic radiation. Conclusion: Exposure to cell phone radiation leads to harmful effects on spermatogenesis and LXRs activation could improve these effects via antioxidant, anti-inflammatory properties in addition to its endocrinal action.","PeriodicalId":7611,"journal":{"name":"Alexandria Journal of Medicine","volume":"57 1","pages":"82 - 91"},"PeriodicalIF":0.9,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/20905068.2021.1884333","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49281075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：