Pub Date : 2023-03-23DOI: 10.1080/20905068.2023.2187538
Mohamed Gamaleldin Elsakkar, Rana Abdullah Alabdulhadi, Ghader Mohammed Alkazzaz, Zuhur Jafar Al-Qteeb, Md. Ashraful Islam
{"title":"Assessment of the knowledge of basic first aid of acute poisoning among medical students at Imam Abdulrahman bin Faisal University, KSA","authors":"Mohamed Gamaleldin Elsakkar, Rana Abdullah Alabdulhadi, Ghader Mohammed Alkazzaz, Zuhur Jafar Al-Qteeb, Md. Ashraful Islam","doi":"10.1080/20905068.2023.2187538","DOIUrl":"https://doi.org/10.1080/20905068.2023.2187538","url":null,"abstract":"","PeriodicalId":7611,"journal":{"name":"Alexandria Journal of Medicine","volume":" ","pages":""},"PeriodicalIF":0.9,"publicationDate":"2023-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44286162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-15DOI: 10.1080/20905068.2023.2183455
Mohamed Zakareya, W. Elshazly, Ahmed Moaz, B. Hegazy
{"title":"Assessment of feasibility of abdominal mesh vaginorectopexy in the repair of multiple pelvic organ prolapse","authors":"Mohamed Zakareya, W. Elshazly, Ahmed Moaz, B. Hegazy","doi":"10.1080/20905068.2023.2183455","DOIUrl":"https://doi.org/10.1080/20905068.2023.2183455","url":null,"abstract":"","PeriodicalId":7611,"journal":{"name":"Alexandria Journal of Medicine","volume":" ","pages":""},"PeriodicalIF":0.9,"publicationDate":"2023-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44434039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-31DOI: 10.1080/20905068.2023.2212531
K. Awad, Y. El-Nahhal
{"title":"Ocular abnormalities among patients with Down syndrome","authors":"K. Awad, Y. El-Nahhal","doi":"10.1080/20905068.2023.2212531","DOIUrl":"https://doi.org/10.1080/20905068.2023.2212531","url":null,"abstract":"","PeriodicalId":7611,"journal":{"name":"Alexandria Journal of Medicine","volume":"1 1","pages":""},"PeriodicalIF":0.9,"publicationDate":"2022-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"60071438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-09DOI: 10.1080/20905068.2022.2140987
A. Abou-Raya, M. Rizk, E. Abdelghani, N. Abdelmegid
{"title":"Identification of serum micro-RNAs of early knee osteoarthritis in a cohort of Egyptian patients","authors":"A. Abou-Raya, M. Rizk, E. Abdelghani, N. Abdelmegid","doi":"10.1080/20905068.2022.2140987","DOIUrl":"https://doi.org/10.1080/20905068.2022.2140987","url":null,"abstract":"","PeriodicalId":7611,"journal":{"name":"Alexandria Journal of Medicine","volume":"1 1","pages":""},"PeriodicalIF":0.9,"publicationDate":"2022-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46687410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-10-25DOI: 10.1080/20905068.2022.2132603
Walaa Sheba, E. Morsy, Salah Altahan, Mona W. Ayaad, S. A. Lashen
ABSTRACT Background Left ventricular diastolic dysfunction (LVDD) is the first preclinical sign of diabetic cardiomyopathy. Nonalcoholic fatty liver disease (NAFLD) is linked to morbidity and mortality in Type 2 diabetes mellitus (T2DM) and increases the chance of developing cardiovascular disease, the primary cause of death. Aim This work aimed to identify the association of LVDD and NAFLD in T2DM. Methods We recruited 40 patients with T2DM (20 with NAFLD and 20 without NAFLD). Laboratory investigations and abdominal ultrasonography were carried out. The degree of hepatic steatosis was measured by the hepatorenal index (HRI). The LVDD was assessed by echocardiography and tissue doppler imaging. Results The Left atrial volume, left ventricular volume index, and left ventricle filling pressure index (E/é) were higher in the NAFLD group (P < 0.05). The E/é index was correlated with HRI and gamma-glutamyl transpeptidase (P < 0.05). Hepatic steatosis by HRI was the only independent variable associated with LVDD. Conclusion NAFLD is associated and correlated with an increased risk of left ventricular diastolic dysfunction in patients with T2DM regardless of ventricular systolic function.
{"title":"Nonalcoholic fatty liver disease is associated with early left ventricular diastolic dysfunction in patients with type 2 diabeteS","authors":"Walaa Sheba, E. Morsy, Salah Altahan, Mona W. Ayaad, S. A. Lashen","doi":"10.1080/20905068.2022.2132603","DOIUrl":"https://doi.org/10.1080/20905068.2022.2132603","url":null,"abstract":"ABSTRACT Background Left ventricular diastolic dysfunction (LVDD) is the first preclinical sign of diabetic cardiomyopathy. Nonalcoholic fatty liver disease (NAFLD) is linked to morbidity and mortality in Type 2 diabetes mellitus (T2DM) and increases the chance of developing cardiovascular disease, the primary cause of death. Aim This work aimed to identify the association of LVDD and NAFLD in T2DM. Methods We recruited 40 patients with T2DM (20 with NAFLD and 20 without NAFLD). Laboratory investigations and abdominal ultrasonography were carried out. The degree of hepatic steatosis was measured by the hepatorenal index (HRI). The LVDD was assessed by echocardiography and tissue doppler imaging. Results The Left atrial volume, left ventricular volume index, and left ventricle filling pressure index (E/é) were higher in the NAFLD group (P < 0.05). The E/é index was correlated with HRI and gamma-glutamyl transpeptidase (P < 0.05). Hepatic steatosis by HRI was the only independent variable associated with LVDD. Conclusion NAFLD is associated and correlated with an increased risk of left ventricular diastolic dysfunction in patients with T2DM regardless of ventricular systolic function.","PeriodicalId":7611,"journal":{"name":"Alexandria Journal of Medicine","volume":"58 1","pages":"117 - 124"},"PeriodicalIF":0.9,"publicationDate":"2022-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42891864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-10-22DOI: 10.1080/20905068.2022.2132604
Mujinya Pastori, Kembambazi Stella, Wandera Allan, Robert Siida, Jackie Rachael Mpumbya, Adomi Mbina Solomon, D. Okumu, Dominic Terkimbi Swase, Kyobe Ronald Kimanje, K. Eliah, Ondari Erick Nyakundi, Niwamanya Boaz
ABSTRACT Background: Failure of endogenous antioxidant system to eliminate high levels of ROS results to oxidative stress, consequently leading to liver damage. Excessive alcohol consumption leads to liver damage due to ROS generation, thus regarded as the leading causes of death worldwide, suggesting great need for use of exogenous antioxidants like epigallocatechin-3-gallate (EGCG), to avert liver damage. However, underlying EGCG mechanisms remains elusive.Aim of the work: This study focused on mechanistic role of EGCG in regulation of antioxidant marker activities during ethanol induced liver damage.Materials and Methods: 20 male Swiss Albino mice were divided into four groups and treated with different dosage. ALT, AST and total proteins were determined as indicators of liver damage. MDA and protein carbonyls were measured as oxidative stress markers. Activities of SOD and CAT were determined. SOD-2 and CAT differential gene expression were also determined. Liver histology analysis by H&E staining. All the experiments were run in duplicates. ANOVA was used to analyzes data using Tukey’s multiple comparison tests and results considered statistically significant if p ≤ 0.05 at 95% confidence level. Results: Findings revealed that chronic consumption of ethanol leads to liver damage through increased levels of serum ALT and AST, MDA, protein carbonyls and remarkable diffuse lipid droplets and decreased enzyme activity of SOD and CAT. EGCG increased activity of SOD and CAT and SOD-2 expression and did not affect CAT expression. Conclusion: In summary, ethanol induces liver damage, and administration of EGCG increases antioxidant system expression, suggesting its role in regulating their activities, defensive of oxidative stress through various pathways.
{"title":"Mechanistic role of epigallocatechin-3-gallate in regulation of the antioxidant markers in ethanol induced liver damage in mice","authors":"Mujinya Pastori, Kembambazi Stella, Wandera Allan, Robert Siida, Jackie Rachael Mpumbya, Adomi Mbina Solomon, D. Okumu, Dominic Terkimbi Swase, Kyobe Ronald Kimanje, K. Eliah, Ondari Erick Nyakundi, Niwamanya Boaz","doi":"10.1080/20905068.2022.2132604","DOIUrl":"https://doi.org/10.1080/20905068.2022.2132604","url":null,"abstract":"ABSTRACT Background: Failure of endogenous antioxidant system to eliminate high levels of ROS results to oxidative stress, consequently leading to liver damage. Excessive alcohol consumption leads to liver damage due to ROS generation, thus regarded as the leading causes of death worldwide, suggesting great need for use of exogenous antioxidants like epigallocatechin-3-gallate (EGCG), to avert liver damage. However, underlying EGCG mechanisms remains elusive.Aim of the work: This study focused on mechanistic role of EGCG in regulation of antioxidant marker activities during ethanol induced liver damage.Materials and Methods: 20 male Swiss Albino mice were divided into four groups and treated with different dosage. ALT, AST and total proteins were determined as indicators of liver damage. MDA and protein carbonyls were measured as oxidative stress markers. Activities of SOD and CAT were determined. SOD-2 and CAT differential gene expression were also determined. Liver histology analysis by H&E staining. All the experiments were run in duplicates. ANOVA was used to analyzes data using Tukey’s multiple comparison tests and results considered statistically significant if p ≤ 0.05 at 95% confidence level. Results: Findings revealed that chronic consumption of ethanol leads to liver damage through increased levels of serum ALT and AST, MDA, protein carbonyls and remarkable diffuse lipid droplets and decreased enzyme activity of SOD and CAT. EGCG increased activity of SOD and CAT and SOD-2 expression and did not affect CAT expression. Conclusion: In summary, ethanol induces liver damage, and administration of EGCG increases antioxidant system expression, suggesting its role in regulating their activities, defensive of oxidative stress through various pathways.","PeriodicalId":7611,"journal":{"name":"Alexandria Journal of Medicine","volume":"58 1","pages":"108 - 116"},"PeriodicalIF":0.9,"publicationDate":"2022-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44608267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-08-11DOI: 10.1080/20905068.2022.2103884
R. Ben Othman, E. Talbi, R. Mizouri, N. Ben Amor, A. Gamoudi, Ines Lahmer, O. Berriche, F. Mahjoub, Henda Jamoussi
ABSTRACT Background Nutrition is the most important environmental factor in the development and progression of childhood obesity, which is very common in Arabic countries. Aim Study of associated factors and nutritional status of childhood obesity. Methods This was a comparative study of 50 obese children recruited from the outpatient department of the children’s hospital, as well as 35 controls. The two groups were matched for gender and age. Anthropometric measurements have been undertaken. A food history as well as a frequency of consumption of certain foods were performed. Results There were 32 girls in obese group. Breastfeeding was more common in the control group (p = 0.04) but gestational diabetes, pregnancy weight gain, and macrosomia were greater in obese people (p = 0.002; 0.0001 and 0.004) . Food diversification was early in the obese (p = 0.05). Mobile phone use was higher among obese people (p = 0.001) but time spent watching TV was not significant (p = 0.06). There was no significant difference between the two groups regarding: the number of hours of sleep, and the practice of sport. Sedentary lifestyle concerned 34% of obese versus 8.57% controls. Intense physical activity was practiced by 14.29% of the controls against any obese (p = 0.0001). The anthropometric parameters of the parents of the obese were more important than those of the controls. The average BMI of the obese was 25.63 Kg/m2.The frequency of consumption showed a more caloric and fat diet in obese group.The diet of the controls was richer in proteins and lipids but better distributed in MUFA and PUFA, but the energy intake of the obese was significantly higher (10,612 versus 4097 Kcal/d). The mineral and vitamin intakes of the obese were correct. Conclusions The fight against childhood obesity essentially involves prevention and promotion of a good lifestyle.
{"title":"Evaluation of anthropometric profile in obese children: risk factors & eating disorder","authors":"R. Ben Othman, E. Talbi, R. Mizouri, N. Ben Amor, A. Gamoudi, Ines Lahmer, O. Berriche, F. Mahjoub, Henda Jamoussi","doi":"10.1080/20905068.2022.2103884","DOIUrl":"https://doi.org/10.1080/20905068.2022.2103884","url":null,"abstract":"ABSTRACT Background Nutrition is the most important environmental factor in the development and progression of childhood obesity, which is very common in Arabic countries. Aim Study of associated factors and nutritional status of childhood obesity. Methods This was a comparative study of 50 obese children recruited from the outpatient department of the children’s hospital, as well as 35 controls. The two groups were matched for gender and age. Anthropometric measurements have been undertaken. A food history as well as a frequency of consumption of certain foods were performed. Results There were 32 girls in obese group. Breastfeeding was more common in the control group (p = 0.04) but gestational diabetes, pregnancy weight gain, and macrosomia were greater in obese people (p = 0.002; 0.0001 and 0.004) . Food diversification was early in the obese (p = 0.05). Mobile phone use was higher among obese people (p = 0.001) but time spent watching TV was not significant (p = 0.06). There was no significant difference between the two groups regarding: the number of hours of sleep, and the practice of sport. Sedentary lifestyle concerned 34% of obese versus 8.57% controls. Intense physical activity was practiced by 14.29% of the controls against any obese (p = 0.0001). The anthropometric parameters of the parents of the obese were more important than those of the controls. The average BMI of the obese was 25.63 Kg/m2.The frequency of consumption showed a more caloric and fat diet in obese group.The diet of the controls was richer in proteins and lipids but better distributed in MUFA and PUFA, but the energy intake of the obese was significantly higher (10,612 versus 4097 Kcal/d). The mineral and vitamin intakes of the obese were correct. Conclusions The fight against childhood obesity essentially involves prevention and promotion of a good lifestyle.","PeriodicalId":7611,"journal":{"name":"Alexandria Journal of Medicine","volume":"58 1","pages":"102 - 107"},"PeriodicalIF":0.9,"publicationDate":"2022-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46560488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-08-02DOI: 10.1080/20905068.2022.2101083
R. Elsaka, S. Helal, A. Abdelhady, Nourhan. M. Kolaib, Manal. A. Soliman
ABSTRACT Background Identifying hig- risk non-small cell lung cancer (NSCLC) patients is the most contentious area in lung pathology for reducing cancer-related morbidity and mortality. Aim of the work Was to investigate the immunohistochemical expression of CD8, CTLA4, and PD-L1 among different NSCLC histopathological variants and it’s correlation with different clinicopathological variables. Material and Methods Expression of CD8, CTLA4, & PD-L1 was evaluated immunohistochemically in 45 NSCLC cases. Results Higher expression of CD8 tumor infiltrating lymphocytes (TILs) was significantly associated with better progression-free survival (PFS). The expression of CTLA4&PD-L1 on tumor cells was significantly associated with lower PFS. However, smoking status of the studied cases showed no statistically significant correlation with expression of any of the studied immunohistochemical markers. Conclusions Immunostaining for CD8, CTLA4, and PD-L1 could have a major role in the anticipation of PFS of NSCLC cases regardless of their smoking status.
{"title":"Immunohistochemical expression of CD8, CTLA4, and PD-L1 in NSCLC of smokers versus non smokers and its effect on prognosis","authors":"R. Elsaka, S. Helal, A. Abdelhady, Nourhan. M. Kolaib, Manal. A. Soliman","doi":"10.1080/20905068.2022.2101083","DOIUrl":"https://doi.org/10.1080/20905068.2022.2101083","url":null,"abstract":"ABSTRACT Background Identifying hig- risk non-small cell lung cancer (NSCLC) patients is the most contentious area in lung pathology for reducing cancer-related morbidity and mortality. Aim of the work Was to investigate the immunohistochemical expression of CD8, CTLA4, and PD-L1 among different NSCLC histopathological variants and it’s correlation with different clinicopathological variables. Material and Methods Expression of CD8, CTLA4, & PD-L1 was evaluated immunohistochemically in 45 NSCLC cases. Results Higher expression of CD8 tumor infiltrating lymphocytes (TILs) was significantly associated with better progression-free survival (PFS). The expression of CTLA4&PD-L1 on tumor cells was significantly associated with lower PFS. However, smoking status of the studied cases showed no statistically significant correlation with expression of any of the studied immunohistochemical markers. Conclusions Immunostaining for CD8, CTLA4, and PD-L1 could have a major role in the anticipation of PFS of NSCLC cases regardless of their smoking status.","PeriodicalId":7611,"journal":{"name":"Alexandria Journal of Medicine","volume":"58 1","pages":"92 - 101"},"PeriodicalIF":0.9,"publicationDate":"2022-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46645169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-07-15DOI: 10.1080/20905068.2022.2094882
S. Lokpo, Wisdom Amenyega, Prosper Doe, J. Osei-Yeboah, W. Owiredu, C. Obirikorang, E. A. Adu, P. Agordoh, Emmanuel Ativi, N. K. Kortei, Samuel Ametepe, V. Orish
ABSTRACT Background Visceral obesity is associated with increased risk of metabolic disorders and cardiovascular disease, hence, diagnosing visceral fat is indispensable in clinical practice. However, the diagnostic capacity of waist–hip ratio (WHR), conicity index (CI), and abdominal volume index (AVI) to predict visceral obesity in patients with type 2 diabetes remains unclear. This study was designed to evaluate the performance of WHR, CI, and AVI in predicting visceral fat among patients with type 2 diabetes in Ho municipality. Methods A hospital-based cross-sectional survey involved 221 patients with type 2 diabetes. A questionnaire was designed to collect data on demography and other relevant variables. Anthropometric measurements were obtained using standard methods. Visceral fat was measured using bioelectrical impedance analysis (BIA). The diagnostic performance of WHR, CI, and AVI in predicting visceral fat was evaluated based on receiver operating characteristics (ROC) curve analyses. Pearson correlation analysis was used to determine the relationship between adiposity indices and visceral fat. Results Among men, the optimal threshold for AVI, >15.56, demonstrated the highest sensitivity, 87.5% and specificity, 80.71% compared to CI and WHR while among women, the optimal cutoff value for AVI, >18.49, produced the highest sensitivity, 77.05% and specificity, 85.29%. Likewise, AVI showed a better discriminatory ability in the diagnosis of visceral fat (AUC: 0.89; p < 0.001) compared to CI (AUC: 0.68; p < 0.003), and WHR (AUC: 0.73; p < 0.001) in men and AUC: 0.89; p < 0.001 compared to CI (AUC: 0.62; p < 0.023), and WHR (AUC: 0.59; p < 0.066) in women. Similarly, the strongest positive correlation was observed between visceral fat and AVI after adjustment for age (male r = 0.787, p < 0.01; female r = 0.770, p < 0.01). Conclusion AVI appeared to have outperformed CI and WHR in the diagnosis of visceral fat. Therefore, it could be a better predictive tool for visceral obesity among patients with type 2 diabetes in low-resource settings.
{"title":"Abdominal volume index is a better predictor of visceral fat in patients with type 2 diabetes: a cross-sectional study in Ho municipality, Ghana","authors":"S. Lokpo, Wisdom Amenyega, Prosper Doe, J. Osei-Yeboah, W. Owiredu, C. Obirikorang, E. A. Adu, P. Agordoh, Emmanuel Ativi, N. K. Kortei, Samuel Ametepe, V. Orish","doi":"10.1080/20905068.2022.2094882","DOIUrl":"https://doi.org/10.1080/20905068.2022.2094882","url":null,"abstract":"ABSTRACT Background Visceral obesity is associated with increased risk of metabolic disorders and cardiovascular disease, hence, diagnosing visceral fat is indispensable in clinical practice. However, the diagnostic capacity of waist–hip ratio (WHR), conicity index (CI), and abdominal volume index (AVI) to predict visceral obesity in patients with type 2 diabetes remains unclear. This study was designed to evaluate the performance of WHR, CI, and AVI in predicting visceral fat among patients with type 2 diabetes in Ho municipality. Methods A hospital-based cross-sectional survey involved 221 patients with type 2 diabetes. A questionnaire was designed to collect data on demography and other relevant variables. Anthropometric measurements were obtained using standard methods. Visceral fat was measured using bioelectrical impedance analysis (BIA). The diagnostic performance of WHR, CI, and AVI in predicting visceral fat was evaluated based on receiver operating characteristics (ROC) curve analyses. Pearson correlation analysis was used to determine the relationship between adiposity indices and visceral fat. Results Among men, the optimal threshold for AVI, >15.56, demonstrated the highest sensitivity, 87.5% and specificity, 80.71% compared to CI and WHR while among women, the optimal cutoff value for AVI, >18.49, produced the highest sensitivity, 77.05% and specificity, 85.29%. Likewise, AVI showed a better discriminatory ability in the diagnosis of visceral fat (AUC: 0.89; p < 0.001) compared to CI (AUC: 0.68; p < 0.003), and WHR (AUC: 0.73; p < 0.001) in men and AUC: 0.89; p < 0.001 compared to CI (AUC: 0.62; p < 0.023), and WHR (AUC: 0.59; p < 0.066) in women. Similarly, the strongest positive correlation was observed between visceral fat and AVI after adjustment for age (male r = 0.787, p < 0.01; female r = 0.770, p < 0.01). Conclusion AVI appeared to have outperformed CI and WHR in the diagnosis of visceral fat. Therefore, it could be a better predictive tool for visceral obesity among patients with type 2 diabetes in low-resource settings.","PeriodicalId":7611,"journal":{"name":"Alexandria Journal of Medicine","volume":"58 1","pages":"85 - 91"},"PeriodicalIF":0.9,"publicationDate":"2022-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45982070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-06-27DOI: 10.1080/20905068.2022.2084868
Ahmed A. Eldesouqi, R. Ragab, Abdel Ghoneim, Bassma Mohamed Sabaa, A. Rafalla
ABSTRACT Background Giant cell tumor (GCT) of bone is a benign locally aggressive tumor that constitutes 20% of the body's benign bone tumors. Most of the GCTs exhibit a typical epiphyseal location that shows a tendency for significant bone destruction and local recurrence. We aimed to assess the functional and oncological outcomes of GCT patients treated with bone grafting and cementation with or without gel foam. Materials and methods This prospective study included 40 patients presented at El Hadara University Hospital with GCT of bone around the knee from January 2017 to January 2022 treated by bone graft and cementation. Twenty cases were treated with gel foam (Group I) and 20 cases were treated without gel foam (Group II) through random allocation without selection. Recurrence was assessed as progressive lysis of 5 mm at the bone cement interface. Functional outcomes were assessed using the musculoskeletal tumor society score (MSTS) after a period of minimum 30 months. Results In Group I, 18 patients (90%) had excellent results (range 24 and 30) according to MSTS and two patients (10%) had good results (range 18 and 23), while in Group II, 16 patients (80%) had excellent results and four patients (20%) had good results. No patients were graded as having fair or poor results. Twenty patients (100%) had satisfactory results, and no patients (0%) had unsatisfactory results. The overall recurrence rate was about 15%. Conclusion Reconstruction of GCT of bone with sandwich technique offers good option as joint preserving surgery. Most of the patients get benefit in terms of better quality of life and good function regardless of age and gender. Subchondral bone grafting reduces the effect of heat on articular cartilage, but longer follow-up is required. There is no benefit of gel foam addition in terms of function or oncological outcome.
{"title":"Treatment of giant cell tumor of bone using bone grafting and cementation with versus without gel foam","authors":"Ahmed A. Eldesouqi, R. Ragab, Abdel Ghoneim, Bassma Mohamed Sabaa, A. Rafalla","doi":"10.1080/20905068.2022.2084868","DOIUrl":"https://doi.org/10.1080/20905068.2022.2084868","url":null,"abstract":"ABSTRACT Background Giant cell tumor (GCT) of bone is a benign locally aggressive tumor that constitutes 20% of the body's benign bone tumors. Most of the GCTs exhibit a typical epiphyseal location that shows a tendency for significant bone destruction and local recurrence. We aimed to assess the functional and oncological outcomes of GCT patients treated with bone grafting and cementation with or without gel foam. Materials and methods This prospective study included 40 patients presented at El Hadara University Hospital with GCT of bone around the knee from January 2017 to January 2022 treated by bone graft and cementation. Twenty cases were treated with gel foam (Group I) and 20 cases were treated without gel foam (Group II) through random allocation without selection. Recurrence was assessed as progressive lysis of 5 mm at the bone cement interface. Functional outcomes were assessed using the musculoskeletal tumor society score (MSTS) after a period of minimum 30 months. Results In Group I, 18 patients (90%) had excellent results (range 24 and 30) according to MSTS and two patients (10%) had good results (range 18 and 23), while in Group II, 16 patients (80%) had excellent results and four patients (20%) had good results. No patients were graded as having fair or poor results. Twenty patients (100%) had satisfactory results, and no patients (0%) had unsatisfactory results. The overall recurrence rate was about 15%. Conclusion Reconstruction of GCT of bone with sandwich technique offers good option as joint preserving surgery. Most of the patients get benefit in terms of better quality of life and good function regardless of age and gender. Subchondral bone grafting reduces the effect of heat on articular cartilage, but longer follow-up is required. There is no benefit of gel foam addition in terms of function or oncological outcome.","PeriodicalId":7611,"journal":{"name":"Alexandria Journal of Medicine","volume":"58 1","pages":"78 - 84"},"PeriodicalIF":0.9,"publicationDate":"2022-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49090540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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