{"title":"Biological properties of virus-induced interferons.","authors":"D C Burke","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":76584,"journal":{"name":"Texas reports on biology and medicine","volume":"41 ","pages":"13-8"},"PeriodicalIF":0.0,"publicationDate":"1981-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17248749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Purification and characterization of interferons.","authors":"E Sulkowski","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":76584,"journal":{"name":"Texas reports on biology and medicine","volume":"41 ","pages":"234-9"},"PeriodicalIF":0.0,"publicationDate":"1981-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17248762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S Pestka, M Evinger, S Maeda, E Rehberg, P C Familletti, B Kelder
{"title":"Biological properties of natural and recombinant interferons.","authors":"S Pestka, M Evinger, S Maeda, E Rehberg, P C Familletti, B Kelder","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":76584,"journal":{"name":"Texas reports on biology and medicine","volume":"41 ","pages":"31-6"},"PeriodicalIF":0.0,"publicationDate":"1981-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17250106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Potentiation of interferon action was described as a non-additive, synergistic enhancement of interferon activity by combined preparations of immune and virus-type interferons. The potentiated antiviral activity was demonstrated for a variety of virus types as well as for the human and mouse in vitro systems. Potentiation by combined immune and fibroblast interferons was also demonstrated for the antitumor and direct anticellular effects of interferon. Use of partially purified immune and fibroblast interferons demonstrated that potentiation appeared to be a property of the interferon molecules themselves.
{"title":"Potentiation of interferon action.","authors":"L A Schwarz, W R Fleischmann","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Potentiation of interferon action was described as a non-additive, synergistic enhancement of interferon activity by combined preparations of immune and virus-type interferons. The potentiated antiviral activity was demonstrated for a variety of virus types as well as for the human and mouse in vitro systems. Potentiation by combined immune and fibroblast interferons was also demonstrated for the antitumor and direct anticellular effects of interferon. Use of partially purified immune and fibroblast interferons demonstrated that potentiation appeared to be a property of the interferon molecules themselves.</p>","PeriodicalId":76584,"journal":{"name":"Texas reports on biology and medicine","volume":"41 ","pages":"298-306"},"PeriodicalIF":0.0,"publicationDate":"1981-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17250108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The hormonal nature of the interferon system.","authors":"E M Smith, J E Blalock","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":76584,"journal":{"name":"Texas reports on biology and medicine","volume":"41 ","pages":"350-8"},"PeriodicalIF":0.0,"publicationDate":"1981-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17250114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Comparison of interferon, lymphokines, and monokines.","authors":"G E Gifford","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":76584,"journal":{"name":"Texas reports on biology and medicine","volume":"41 ","pages":"59-63"},"PeriodicalIF":0.0,"publicationDate":"1981-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17250123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The interferon inducer moiety of viruses: a single molecule of dsRNA.","authors":"P I Marcus","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":76584,"journal":{"name":"Texas reports on biology and medicine","volume":"41 ","pages":"70-5"},"PeriodicalIF":0.0,"publicationDate":"1981-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17250124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The results of studies briefly summarized in this review indicate that: a/ ds-RNAs can induce IFN in man, however, their toxicities are still a serious obstacle for systemic use. b/ The IFN inducing capacity of the known inducers is determined more by physical than by chemical properties of the molecule and the toxicities exerted are neither specific nor unique for ds-RNAs. Several studies indicate that they may result from or be potentiated by the cooperative effect of the induced IFN. c/ The systemic use of ds-RNAs, so far, brought no conclusive evidence of their effectiveness in viral or cancer diseases of man. The rare beneficial effect observed in some cancer and, presumably, non-viral diseases requires reexamination. d/ Topical application remains the safest way of their effective exploitation in man. However, tests with standardized preparations are required before including ds-RNAs in the armament of physician.
{"title":"Therapeutic use of double-stranded RNAs in man.","authors":"L Borecký, V Lackovic, J Rovenský","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The results of studies briefly summarized in this review indicate that: a/ ds-RNAs can induce IFN in man, however, their toxicities are still a serious obstacle for systemic use. b/ The IFN inducing capacity of the known inducers is determined more by physical than by chemical properties of the molecule and the toxicities exerted are neither specific nor unique for ds-RNAs. Several studies indicate that they may result from or be potentiated by the cooperative effect of the induced IFN. c/ The systemic use of ds-RNAs, so far, brought no conclusive evidence of their effectiveness in viral or cancer diseases of man. The rare beneficial effect observed in some cancer and, presumably, non-viral diseases requires reexamination. d/ Topical application remains the safest way of their effective exploitation in man. However, tests with standardized preparations are required before including ds-RNAs in the armament of physician.</p>","PeriodicalId":76584,"journal":{"name":"Texas reports on biology and medicine","volume":"41 ","pages":"575-81"},"PeriodicalIF":0.0,"publicationDate":"1981-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17816179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Antitumor effects of interferon and its possible use as an antineoplastic agent.","authors":"H Strander","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":76584,"journal":{"name":"Texas reports on biology and medicine","volume":"41 ","pages":"621-5"},"PeriodicalIF":0.0,"publicationDate":"1981-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17816180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The interferon system: a review to 1982-Part I.","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":76584,"journal":{"name":"Texas reports on biology and medicine","volume":"41 ","pages":"1-410"},"PeriodicalIF":0.0,"publicationDate":"1981-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17248744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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