Zeitschrift fur experimentelle Chirurgie最新文献

The biostimulatic effect of laser radiation was proved in animal investigations and also observed in 259 patients with disturbed wound healing. Laser rays can be applied without any risk in patients. The therapy was successful in over 90% of the patients. The duration of the therapy amounted to 10 to 12 weeks on an average.

An experimental shock model with rabbits and dogs was used (bleeding to an constant systemic pressure of 5.3-6.6 kPa) to investigate quality and time dependency of intra-extracellular gradients of Na+, K+ and Ca++ in skeletal and heart muscle. We found the ion gradient changes to be earlier and more pronounces in skeletal than in heart muscle, where strongest changes appear within the heart ears and significant smaller ones within ventricular and papillar muscles. Unexpectedly there was in heart and skeletal muscle the same two phasic ionic course, and a close correlation between ion gradient changes and shock duration in skeletal muscle. There is a good agreement between our results and the common clinical observations of ventricular arrhythmia caused by acute hypotonic circulatory situation and therefore the early restoration of the disturbed transcapillary exchange in the peripheral circulation is demanded.

The sonographic differentation of solidly growing and displacing processes is discussed so far only with a high factor of insecurity. The ultrasonic spectroscopy makes it possible for an approximate differentation of the tissue in the experimental investigations in vitro by the reception of bioacoustic parameters. Certainly some questions are open in case of the different forms of neoplasia of the testes. The spreading of the impulse sound field in the tissue cannot be described exactly up to today, because of the indistinct acoustic qualities of the structure in the macroscopic and microscopic region. The clearing of the biophysical reciprocity between sound field and tissue stands in the foreground of the future investigations. The ultrasonic spectroscopy performs despite of the open problems a constructive share to the findings in pathological processes of the testes.

Experimental orthotopic renal allotransplantation performed in pigs allowed us to verify some techniques of ureterocystoneostomies from the urological point of view. For the reconstruction of the urinary pathways we employed anastomosis in 7 cases, and implantation of the ureter into the bladder in 3 cases, using the antireflux technique in 9 animals and the now common ureteral implantation with the terminal segment of the ureter placed in tunnel serosa in 24 animals. The results of our modification confirm the importance of peritoneal plasty of the terminal ureteral segment for the prevention of urinary fistulas. This technique seems to be applicable to reconstruction of urinary pathways in humans.

Pluronic F 108 added to serum in a concentration of 1 g/dl proved as the optimal means to increase the fat emulgatory capacity. Similar concentrations were achieved in living rabbits by infusing 4.5 g per kg body weight. In spite of this higher dosage we failed to mobilize 131 J labelled fat, embolized into the lungs of the animals. It is concluded that also in humans there exists no possibility to mobilize fat emboli from the lungs by the application of tensides (non-ionic detergents, lecithin-preparations, bile salts) or of organic solvents (alcohol, ether). All these agents are capable to emulsify fat in vitro, however, only under vigorous shaking.--Because of the side effects of those agents their application on patients, suffering from posttraumatic fat embolism seems not to be justified.

The function of the ileo-ureter and the operated kidney was investigated by means of the camera functional scintigraphy in 23 dogs operated under different techniques. This non-invasive examination was carried out with two different radio-remedies (131I-Hippuran and 99mTc-DTPA) by a gamma camera microprocessor. The direct single-layered ileo-ureteric anastomosis showed the best urine transportation. This method has a great practical importance in the opinions of the authors.

A critical consideration of the modern situation of the diagnostics and therapy of the bronchial carcinoma shows compared with the expense a proportionately small healing quotient of nearly 7% of all diagnosed bronchial cancers. The analysis of the possibilities of the present ways for the therapy shows that an additional improvement of the operative and immediate postoperative results could not lead to a substantial modification of the healing quotient altogether. An improvement is possible only through an increase of the number of operable patients at the moment of the diagnosis. This requires a radical modification of the methods for the early diagnosis. Possible ways for them are shown. A smaller improvement of the healing quotient could be achieved by the intensification and the correction of the after treatment in the later time, inclusively the well-timed and effective treatment of relapse and metastases. The healing quotient after five years may probably be doubled with the right use of the above mentioned measures.

The eventual causes of the lesion of the vascular wall through electric direct current (D. C.) in experimental artificial thrombosis are discussed by means of microscopic investigations by electron microscope and light microscope in altogether 73 mongrel dogs and 14 mini pigs. No thermic lesions of the vascular wall were observed in the coronary thrombosis pattern on the closed thorax by means of 1 mA amperage and an induction time of 60 minutes. Secondary processes for cell lesions are to be made responsible in which the electrolysis on the cell membrane and the influence of functional ranges in the artery wall play an important part.

Only the test by Burge shows an effective evidence among the intraoperative control methods for testing the completeness of section during selective proximal vagotomy. The postoperative results are discussed in this study. 78 patients of 91 could be controlled endoscopically 3 to 60 months postoperatively. The result of the group with the Burge test (n = 38) does not differ essentially from the group without the Burge test (n = 40). However, the Burge test has a didactic importance certainly for surgeons in the training.