Zeitschrift fur experimentelle Chirurgie最新文献

The substitutes could be decontaminated by means of six to eight times soaking into sterile sodium chloride solution (154 mmol/l = 9 g/l) in each case half an hour if a short preparation time for the implantation of protein cross-linked and methanal storaged bioprotheses is existent. This procedure must be carried out under strict aseptic conditions. A microbial recontamination of the preparations threats moreover.

Introduction and discussion of an experimental animal model to the representation of an isolated lung contusion in rats. The damage is realized by means of pressure waves. There can be observed distinct lung contusions - even unilateral - without chest wall lesions or extrathoracal injuries. One can also recognize temporal lapses of different intensity of the trauma. The model appears suitable to the presentation of a possible independent pathogenesis of the lung contusion.

The influence of the duodenogastric reflux of the carcinogenesis in the operated stomach was tested in an animal experiment in 47 Wistar rats. Cancers were observable differently frequently under various intensity of the reflux dependent on the operation method. The carcinogenesis in the operated stomach (gastric stump carcinoma) will be influenced decisively by the duodenogastric reflux in the opinion of the authors. Conclusions for the practice were pointed out.

An animal experimental study was carried out in order to compare the therapeutical value of two different surgical methods for excising the subcutaneous implanted Lewis lung carcinoma - tumor excision with scalpel or with carbon dioxide laser. The radicalism of operation methods, the survival time, and the tumor local recurrences were performed. The therapeutic effectivity of tumor excision with the carbon dioxide laser is more favourable than the scalpel method.

The importance of kidneys from newborn donors in transplantation has not been clearly defined. The purpose of this study was to investigate the degree of morphological and functional adaptation of the newborn kidney in an adult recipient. 7 MLS-matched kidneys from Lewe minipig puppies (age: 3-4 weeks) had been transplanted en bloc to their mothers with immediately bilateral nephrectomy. Preliminary results suggested that arterial vasculature and blood supply are the limiting factors in adaptation of newborn donor kidneys in adult recipients.

An animal experimental model for the additional vascularisation of the kidney is represented by means of an excluded demucosed small intestine segment. The immediate clinical signification is to be seen in lowering the hypertension in case of pyelonephritic renal shrinkage. Histologic investigations do not show any vascular communication between intestine and kidney and not any ingrowing of intestinal vessels in the kidney. If the improvement of reno-intestinal shunts could be particularly stimulated in case of a primary restricted blood offer must remain unsolved.

55 of 113 receivers of cadaver donor kidney transplants could be control-examined and analysed postoperatively immunologically with the electrophoresis mobility test (EM test). A high coincidence appears in the group with clinical rejection symptoms and a rejections hint in the EM test (28 of 29) and also in the group with the rejection clinically not conceivable and with a negative test result (20 of 26). The EM test appears suitable for an additional support of the diagnosis "acute rejection". More cases should confirm this assertion.

In comparative studies in 36 mongrel dogs it was tried to find out how far intraaortic balloon pumping (IABP) applied solely and in combination with glucose-insulin-potassium (GIK) might influence the degree of acute myocardial ischemia. The ischemia lasted 3 hours. After 60 min myocardial ischemia IABP, the isolated GIK infusion, or the combination of IABP plus GIK were used. The directed GIK application into the aortic root was carried out by electronic triggering during the diastolic augmentation via a precoronary catheter. In the ischemic and in the non-ischemic myocardium of the left ventricle, ATP, creatine phosphate, and lactate were determined. Electronmicroscopical studies were carried out qualitatively as well as quantitatively. The isolated use of IABP suggested no protection of the energy-rich phosphates. The most significant morphological changes were found when exclusively the coronary ligature was applied and when only IABP was used, respectively. The best protective effect was achieved by our technique of the triggered GIK infusion via the precoronary catheter in combination with IABP. The ATP value (n mol/mg w.w.) in the ischemic area was 3.06 and in the non-ischemic one 4.96 in comparison to 1.96 and 3.99, respectively, in the control group. The creatine phosphate (n mol/mg w.w.) was 4.18 in the ischemic and 9.38 in the non-ischemic area in contrast to 2.36 and 6.99, respectively, in the control group. The technique of the triggered drug supply in combination with IABP offers the following advantages: --additive summation of IABP and substrate supply directed to the myocardium --high drug concentration in the myocardium --smaller drug load of the whole organism --clinical use of instable substances.

Blood flow measurements in the pancreas were performed in 12 pigs in situ, after the splenectomy, and then after the occlusion of the pancreatic duct by means of prolamin as well during a relaparotomy after 6 weeks. No change was pointed out immediately after the occlusion in face of the state following the splenectomy. The flow in the splenic artery was reduced significantly (p less than or equal to 0.0001) by 62% after 6 weeks.