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Role of computed tomography and MRI in children with sensorineural hearing loss 计算机断层扫描和MRI在儿童感音神经性听力损失中的作用
Pub Date : 2022-01-01 DOI: 10.4103/azmj.azmj_191_20
Ahmad Mohamed Alkady, Saad Rezk Al-Wahed El-Gebaly, T. Mansour, Mohamed Elmoursy Kasem
Background and aim Given the tremendous developments in visualization science, there are many congenital and acquired internal ear anomalies that have no radiological signs. However, visualization is an important instrument for the assessment of congenital and acquired sensory neural hearing loss (SNHL) triggers. The aim is to assess the value of multidetector computed tomography (MDCT) and MRI in internal ear abnormality detection in children with SNHL. Patients and methods This study included 100 children of 10 years or younger with SNHL. The cochlea, the vestibule, the three semicircular canals, the endolymphatic duct, and the internal acoustic canal. In addition, three-dimensional DRIVE MRI gives good demonstration of all four nerves within the internal acoustic canal. Results A total of 46 malformations were detected in only 25 patients with 42 malformations that were detected in MDCT examination presenting 91% of all abnormalities, while in MRI examination, 44 malformations are detected presenting 96% of all abnormalities. MDCT showed accuracy, sensitivity, and specificity 96.7, 91.3, and 100%, respectively, while for MRI, it showed accuracy, sensitivity, and specificity 98.3, 95.7, and 100%, respectively. Conclusion Imaging plays an important role in the workup of children with SNHL. Therefore, it is imperative to define the etiology of hearing loss. High-resolution CT and MRI modalities are the two principal radiological investigations to detect various pathologies in the inner ear. ‘Dual-modality imaging’ using both MRI and CT, made sense for many patients because the dual-scan approaches detect abnormalities related to hearing loss that would not otherwise be found using either modality alone.
背景与目的随着视觉科学的发展,有许多先天性和后天性的内耳异常没有影像学征象。然而,可视化是评估先天性和获得性感觉神经性听力损失(SNHL)触发因素的重要工具。目的是评估多探测器计算机断层扫描(MDCT)和MRI在SNHL患儿内耳异常检测中的价值。患者和方法本研究纳入100例10岁及以下SNHL患儿。耳蜗、前庭、三条半规管、内淋巴管和内声道。此外,三维驱动MRI可以很好地显示内声道内的所有四个神经。结果25例患者共检出46例畸形,其中MDCT检出42例畸形,占全部异常的91%,MRI检出44例畸形,占全部异常的96%。MDCT的准确率、灵敏度和特异性分别为96.7、91.3和100%,MRI的准确率、灵敏度和特异性分别为98.3、95.7和100%。结论影像学检查在儿童SNHL的诊治中起着重要作用。因此,明确听力损失的病因是十分必要的。高分辨率CT和MRI模式是检测内耳各种病理的两种主要放射学调查。使用MRI和CT的“双模成像”对许多患者来说是有意义的,因为双扫描方法可以检测到与听力损失相关的异常,否则单独使用任何一种方式都无法发现这些异常。
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引用次数: 0
Ketoconazole 2% cream versus a combination of ketoconazole 2% cream and adapalene 0.1% gel in the treatment of pityriasis versicolor 2%酮康唑乳膏与2%酮康唑软膏与0.1%阿达帕林凝胶联合治疗花斑癣
Pub Date : 2022-01-01 DOI: 10.4103/azmj.azmj_97_21
K. Tawfik, Waleed Mahmmoud, A. Ali
Background and aim Pityriasis versicolor is a common chronic superficial fungal infection that manifests during or after puberty in hot humid temperatures. Topical treatments, which are the first line of treatment, are divided into nonspecific and specific antifungal agents; however, the therapeutic approaches for pityriasis versicolor depend mainly on synthetic antifungal drugs, in particular ketoconazole. However, due to the frequent recurrence of this disease, and the widespread application of azole drugs, resistant strains have emerged leading to increasingly failed treatment rates. Retinoic acid creams are also effective against pityriasis versicolor. Especially adapalene gel that has less irritation compared with other topical retinoid products and also has rapid onset of action. Therefore, we aimed to evaluate the efficacy and safety of a combination treatment of ketoconazole cream 2% and adapalene gel 0.01% in the treatment of pityriasis versicolor. Patients and methods In all, 100 patients were divided equally into two groups: group 1 patients were treated with topical application ketoconazole 2% cream and adapalene 0.1% gel once daily for a total duration of 2 weeks. Group 2 patients were treated with a topical application ketoconazole 2% cream for a total duration of 2 weeks. Results There was significant improvement rates in the combined group than ketoconazole-only group with P value=0.023. Adepalene+ketoconacole group had more irritation as a side effect than the ketoconazole group with significant P value=0.001. Conclusion The combination of adapalene 0.1% gel and ketoconazole 2% cream is safe, rapid, and effective in the treatment of pityriasis versicolor.
背景和目的花斑癣是一种常见的慢性浅表真菌感染,表现在青春期或青春期后湿热的温度下。局部治疗是第一线治疗,分为非特异性和特异性抗真菌药物;然而,花斑癣的治疗方法主要依赖于合成抗真菌药物,尤其是酮康唑。然而,由于这种疾病的频繁复发,以及唑类药物的广泛应用,出现了耐药性菌株,导致治疗失败率越来越高。维甲酸乳膏对花斑癣也很有效。特别是阿达帕林凝胶,与其他局部类视黄醇产品相比,它的刺激性较小,而且起效快。因此,我们旨在评估2%酮康唑乳膏和0.01%阿达帕林凝胶联合治疗花斑癣的疗效和安全性。患者和方法将100例患者平均分为两组:第一组患者外用2%酮康唑乳膏和0.1%阿达帕林凝胶,每日1次,疗程2周。第2组患者局部应用2%酮康唑乳膏治疗,总持续时间为2周。结果联合用药组疗效明显优于单纯酮康唑组,P值为0.023。阿德帕林+酮康唑组的副作用刺激性大于酮康唑组,显著P值=0.001。结论0.1%阿达帕林凝胶与2%酮康唑乳膏联合治疗花斑癣安全、快速、有效。
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引用次数: 0
Comparison of corneal changes after phacoemulsification in diabetic and nondiabetic eyes 糖尿病与非糖尿病眼超声乳化术后角膜变化的比较
Pub Date : 2022-01-01 DOI: 10.4103/azmj.azmj_130_21
Asmaa Elminshawy, H. Hegazy, M. Aly
Background and aim Endothelium of the cornea is susceptible to surgical trauma during phacoemulsification from ultrasound energy. Several studies have reported various results of corneal changes after phacoemulsification in diabetic and healthy patients. The aim was to evaluate and compare changes in precorneal tear film, anterior and posterior corneal surfaces, endothelial cell changes, and central corneal thickness (CCT) between diabetic and healthy patients before and after uneventful phacoemulsification. Patients and methods A total of 40 eyes of 40 patients who were scheduled for cataract surgery were divided into group 1 (20 eyes in nondiabetic patients) and group 2 (20 eyes in diabetic patients). Ophthalmological examinations, including uncorrected and best-corrected visual acuity (BCVA), slit lamp to examine anterior and posterior corneal surfaces, tear film breakup time test (TBUT), anterior chamber depth by IOL Master (Topcon ALADDIN HW2.0), and specular microscopy (Topcon SP-1P, made In Japan), were done preoperatively and at 1 week, 1 month, and 3 months postoperatively. Results Significant differences were found between preoperative and postoperative periods in both groups regarding BCVA, TBUT, CCT, endothelial cell density (ECD), coefficient of variation, and hexagonal cells, except that changes became insignificant with respect to CCT at 3 months in nondiabetic and at 1 week and 3 months in diabetic and in CD at 1 month in healthy patients. Conclusion There were significant changes in BCVA, TBUT, CCT, and ECD after phacoemulsification in the diabetic and healthy groups. There was a significant delay in the recovery of CCT 1 month after phacoemulsification in the diabetic compared with healthy individuals.
背景与目的超声乳化术中角膜内皮易受手术损伤。一些研究报道了糖尿病和健康患者超声乳化术后角膜变化的不同结果。目的是评估和比较糖尿病患者和健康患者在正常超声乳化术前后角膜前泪膜、角膜前后表面、内皮细胞变化和角膜中央厚度(CCT)的变化。选取40例拟行白内障手术的患者40只眼,分为1组(非糖尿病患者20只眼)和2组(糖尿病患者20只眼)。术前、术后1周、1个月、3个月进行眼科检查,包括未矫正和最佳矫正视力(BCVA)、裂隙灯检查角膜前后表面、泪膜破裂时间测试(TBUT)、IOL Master (Topcon ALADDIN HW2.0)前房深度、镜面显微镜(Topcon SP-1P,日本制造)。结果两组患者术前和术后BCVA、TBUT、CCT、内皮细胞密度(ECD)、变异系数、六角形细胞差异均有统计学意义,但非糖尿病患者3个月、糖尿病患者1周和3个月、健康患者1个月的CCT变化不显著。结论糖尿病组与健康组超声乳化术后BCVA、TBUT、CCT、ECD均有显著变化。超声乳化术后1个月,糖尿病患者的CCT恢复明显延迟。
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引用次数: 0
Prevalence of pathological myopia in Upper Egypt 上埃及地区病理性近视的患病率
Pub Date : 2022-01-01 DOI: 10.4103/azmj.azmj_143_21
Mai Ahmed
Background and aim Pathological myopia (PM) is one of the main causes of blindness globally, and its prevalence continues to increase rapidly over time. The aim of this study was to investigate the prevalence of PM in the clinical population in Assiut City, Upper Egypt, during a period of 1 year. Patients and methods This cross-sectional study was carried out on a clinical population attending a large ophthalmology center in Assiut City, Upper Egypt, during the period from January to December 2018. All patients were subjected to full ophthalmologic examination. The noncycloplegic refraction was measured using an autorefractometer. The examined eyes were diagnosed as PM if they had refraction of more than or equal to −6 D spherical equivalent or an axial length of more than or equal to 25.5 mm. Results The study included 1548 eyes of 812 patients. Pathologically myopic eyes represented 152 eyes, with a prevalence of 9.82%. Of the total included patients, 102 (12.6%) patients had at least one pathologically myopic eye. Patients with bilateral PM represented 73 (71.6%) cases. Their refractive error ranged from −6.0 to −26.0 D, with a mean of −13.24±4.13 D, and their mean axial length was 28.2±2.14 mm and ranged from 26.1 to 35.2 mm. Conclusion The prevalence of PM in the studied sample was 9.82%, which was obviously higher compared with studies on other populations. Further large community-based studies are warranted to determine its prevalence as a step to overcome this true burden.
背景与目的病理性近视(PM)是全球致盲的主要原因之一,其发病率随着时间的推移而迅速上升。本研究的目的是调查上埃及阿西尤特市临床人群在一年内PM的患病率。患者和方法这项横断面研究是在2018年1月至12月期间对上埃及阿西尤特市一家大型眼科中心的临床人群进行的。所有患者均接受了全面的眼科检查。使用自动折射仪测量非环肌麻痹性屈光。如果被检查的眼睛的折射率大于或等于−6 D球面当量或轴向长度大于或等于25.5,则被诊断为PM 结果本研究包括812例患者中的1548眼。病理性近视152眼,患病率9.82%。在纳入的患者中,102名(12.6%)患者至少有一只病理性近视眼。双侧PM患者73例(71.6%)。它们的折射误差范围为−6.0至−26.0 D,平均值为−13.24±4.13 D,平均轴长为28.2±2.14 毫米,范围从26.1到35.2 结论研究样本中PM的患病率为9.82%,与其他人群相比明显升高。有必要进行进一步的大型社区研究,以确定其流行率,作为克服这一真正负担的一步。
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引用次数: 0
The role of glypican 3, arginase 1, and CD34 in differentiation between benign and malignant primary hepatic lesions glypican 3、精氨酸酶1和CD34在原发性肝病变良恶性鉴别中的作用
Pub Date : 2022-01-01 DOI: 10.4103/azmj.azmj_105_21
Said Mohamed, Yasser Eldowik
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引用次数: 1
Treatment of corneal astigmatism by limbal relaxing incisions during phacoemulsification surgery 超声乳化术中角膜缘松弛切口治疗角膜散光
Pub Date : 2022-01-01 DOI: 10.4103/azmj.azmj_22_21
M. Naguib, Hussam-Eldin O Elrashidy, G. Samir
Background and aim The aim was to assess the effectiveness of limbal relaxing incisions (LRIs) in treatment of astigmatism in patients undergoing phacoemulsification surgeries. Patients and methods Forty-eight eyes of 48 patients suffering from senile cataracts of mean age 64.7±7.9 (range: 50–77) years, and mean corneal astigmatism 1.8±0.73 diopters (D) (range: 1.5–3.5 D) were included in this study. All LRIs were performed at the end of phacoemulsification. Corneal topography results were compared before surgeries and 2 and 6 months after surgeries. Results A statistically significant reduction in the mean corneal astigmatism was seen from 1.8±0.73 D (range: 1.50–3.50) preoperatively to 1.1±0.24 D (range: 0.5–1.7) and 1.4±0.52 D (range: 0.60–1.9) in the second and sixth postoperative months, respectively (P<0.001). Surgical-induced astigmatism (the amount and axis of astigmatism change induced by surgery) was 0.90±0.48 at 2 months and 0.96±0.59 at 6 months. Correction index (calculated by determining the ratio of surgical-induced astigmatism/target-induced astigmatism) was 0.56±0.42 and 0.57±0.33 at 2 and 6 months, respectively. Index of success (ratio of topographic residual astigmatism and target-induced astigmatism) was measured to be 0.45±0.42 and 0.48±0.33 at months 2 and 6 correspondingly. Conclusion Combined LRI and phacoemulsification appears to be safe and fairly effective to correct mild-to-moderate corneal astigmatism. However, undercorrection is a common limitation that may be further managed by modified nomograms in future studies.
背景与目的评价角膜缘松弛切口(LRIs)治疗超声乳化术患者散光的效果。患者与方法48例老年性白内障患者48只眼,平均年龄64.7±7.9岁(范围:50 ~ 77岁),平均角膜散光1.8±0.73屈光度(D)(范围:1.5 ~ 3.5 D)。所有LRIs均在超声乳化术结束时进行。比较术前与术后2、6个月角膜地形图结果。结果术后2、6个月平均角膜散光由术前的1.8±0.73 D(范围:1.50 ~ 3.50)降至1.1±0.24 D(范围:0.5 ~ 1.7)、1.4±0.52 D(范围:0.60 ~ 1.9),差异有统计学意义(P<0.001)。手术引起的散光(手术引起的散光量和散光轴变化)2个月时为0.90±0.48,6个月时为0.96±0.59。2个月和6个月校正指数(通过测定手术性散光/靶性散光的比值计算)分别为0.56±0.42和0.57±0.33。第2个月和第6个月的成功指数(地形残余散光与靶致散光的比值)分别为0.45±0.42和0.48±0.33。结论LRI联合超声乳化术治疗轻、中度角膜散光安全有效。然而,校正不足是一个常见的限制,在未来的研究中可以通过修改的图来进一步管理。
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引用次数: 0
Comparing the effect of gonadotropin versus letrozole for induction of ovulation in patients with polycystic ovary syndrome with clomiphene citrate failure 促性腺激素与来曲唑对多囊卵巢综合征合并克罗米芬-柠檬酸盐失败患者促排卵作用的比较
Pub Date : 2022-01-01 DOI: 10.4103/azmj.azmj_78_21
Ahmed M Ali, A. E. Ahmed, A. Elboghdady
Background and aim Polycystic ovary syndrome (PCOS) is an endocrinopathy affecting women during the childbearing period, with incidences of between 8 and 13%. PCOS is the main cause of anovulatory infertility with a prevalence of 20% in infertile women. We aimed to compare the ovulation induction effect of letrozole versus gonadotropins in patients with PCOS after clomiphene citrate (CC) failure. Patients and methods This is a prospective comparative study held in the El Hussien University Hospital, Al-Azhar University; throughout the duration of 12 months from January 2020 to January 2021. In all, 100 women were enrolled in the study diagnosed with PCOS with an ovulatory infertility and after CC failure, patients were allocated into two groups in a ratio of 1 : 1. The first group included 50 patients and received (letrozole 2.5 mg tablet) twice daily. Results There was higher incidence of confirmed ovulation in the gonadotropin group (62%) compared with the letrozole group (58%) with no significance. It also showed a higher incidence of confirmed pregnancy in the gonadotropin group (34%) compared with the letrozole group (30%), but that difference was statistically nonsignificant. The results showed a shorter duration till the day of trigger in the letrozole group (13.48) compared with the gonadotropin group (14.55), the difference was significant. Endometrial thickness on day of trigger was higher in the gonadotropin group (11.3) compared with the letrozole group (10.9) with no significance. Conclusion In patients who failed to conceive with CC, gonadotropins have higher pregnancy rates for ovulation induction than letrozole with an insignificant statistical difference.
背景和目的多囊卵巢综合征(PCOS)是一种影响育龄妇女的内分泌疾病,发病率在8%至13%之间。多囊卵巢综合征是无排卵性不孕的主要原因,不孕妇女的发病率为20%。我们的目的是比较来曲唑和促性腺激素对克罗米芬-柠檬酸盐(CC)失败后多囊卵巢综合征患者的促排卵作用。患者和方法这是一项在爱资哈尔大学侯赛因大学医院进行的前瞻性比较研究;在2020年1月至2021年1月的12个月期间。总共有100名女性被纳入研究,被诊断为多囊卵巢综合征伴排卵性不孕,CC失败后,患者按1:1的比例分为两组。第一组包括50名患者,接受(来曲唑2.5 mg片剂),每天两次。结果促性腺激素组确认排卵的发生率(62%)高于来曲唑组(58%),但无统计学意义。与来曲唑组(30%)相比,促性腺激素组(34%)的确诊妊娠发生率更高,但这一差异在统计学上无统计学意义。结果显示,来曲唑组(13.48)与促性腺激素组(14.55)相比,到触发日的持续时间更短,差异有显著性。促性腺激素组(11.3)在触发当天的子宫内膜厚度高于来曲唑组(10.9),无统计学意义。结论在CC妊娠失败的患者中,促性腺激素诱导排卵的妊娠率高于来曲唑,差异无统计学意义。
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引用次数: 0
Fetal hemoglobin as a predictor in cases of pre-eclampsia 胎儿血红蛋白作为先兆子痫的预测因子
Pub Date : 2022-01-01 DOI: 10.4103/azmj.azmj_113_20
Ahmed A Elrefaei, A. Zakarya, A. Abdel Motaal, A. Assem
{"title":"Fetal hemoglobin as a predictor in cases of pre-eclampsia","authors":"Ahmed A Elrefaei, A. Zakarya, A. Abdel Motaal, A. Assem","doi":"10.4103/azmj.azmj_113_20","DOIUrl":"https://doi.org/10.4103/azmj.azmj_113_20","url":null,"abstract":"","PeriodicalId":7711,"journal":{"name":"Al-Azhar Assiut Medical Journal","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70687774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Laparoscopic versus open appendectomy in patients with acute appendicitis 急性阑尾炎患者的腹腔镜阑尾切除术与开放式阑尾切除术比较
Pub Date : 2022-01-01 DOI: 10.4103/azmj.azmj_11_22
M. Kamel, M. Abdelfattah, Gamal Shimy
{"title":"Laparoscopic versus open appendectomy in patients with acute appendicitis","authors":"M. Kamel, M. Abdelfattah, Gamal Shimy","doi":"10.4103/azmj.azmj_11_22","DOIUrl":"https://doi.org/10.4103/azmj.azmj_11_22","url":null,"abstract":"","PeriodicalId":7711,"journal":{"name":"Al-Azhar Assiut Medical Journal","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70688023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Detection of Helicobacter pylori in paranasal sinus specimens from chronic rhinosinusitis patients 慢性鼻窦炎患者鼻窦标本幽门螺杆菌的检测
Pub Date : 2022-01-01 DOI: 10.4103/azmj.azmj_2_22
Mohamed Al Awady, MohamedM Hamed Alahmer, M. El-Morsy, O. Mostafa
{"title":"Detection of Helicobacter pylori in paranasal sinus specimens from chronic rhinosinusitis patients","authors":"Mohamed Al Awady, MohamedM Hamed Alahmer, M. El-Morsy, O. Mostafa","doi":"10.4103/azmj.azmj_2_22","DOIUrl":"https://doi.org/10.4103/azmj.azmj_2_22","url":null,"abstract":"","PeriodicalId":7711,"journal":{"name":"Al-Azhar Assiut Medical Journal","volume":"146 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70689063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
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Al-Azhar Assiut Medical Journal
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