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Effect of corneal collagen cross-linking on higher-order aberrations in patients with early keratoconus 角膜胶原交联对早期圆锥角膜高阶像差的影响
Pub Date : 2022-01-01 DOI: 10.4103/azmj.azmj_96_21
Shimaa Sayed, H. Yousef, M. Salih
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引用次数: 0
Role of food allergy in otitis media with effusion 食物过敏在渗出性中耳炎中的作用
Pub Date : 2022-01-01 DOI: 10.4103/azmj.azmj_99_21
Wessam Fouad, Sayed Makhemaer, Hala Abd Mohamed, A. Awwad
Background and aim The role of food allergy (FA) in chronic otitis media with effusion (OME) is argumentative. New proof from cellular biology and immunology clarifies the essentials of allergic responses and permits exact diagnosis more than before for allergies and inflammatory disease. We aimed to detect the occurrence of FA in patients with chronic OME. Patients and methods This a prospective, cohort randomized controlled study that was conducted at Al Azhar University Hospital, Otorhinolaryngology Department, on 40 patients divided into two groups: patient group included 20 patients with OME, and control group included 20 patients without any medical problems about FA or OME. The prevalence of FA was detected by skin prick test and assessment of serum immunoglobulin E and eosinophil count. Results There were highly statistically significant correlations between increase in the total serum immunoglobulin E and eosinophil count and developing OME (P<0.00); however, there were no statistically significant correlations between age and developing OME (P<0.396). Conclusion The possibility of association and the contribution of FA should be kept in mind in OME cases.
背景与目的食物过敏(FA)在慢性渗出性中耳炎(OME)中的作用是有争议的。细胞生物学和免疫学的新证据阐明了过敏反应的本质,并比以前更准确地诊断过敏和炎症性疾病。我们旨在检测FA在慢性OME患者中的发生情况。患者和方法这是一项前瞻性、队列随机对照研究,在爱资哈尔大学医院耳鼻喉科对40名患者进行,分为两组:患者组包括20名OME患者,对照组包括20例没有任何FA或OME医疗问题的患者。通过皮肤点刺试验和血清免疫球蛋白E和嗜酸性粒细胞计数评估FA的患病率。结果血清总免疫球蛋白E和嗜酸性粒细胞计数的增加与OME的发生具有高度统计学意义(P<0.00);但年龄与OME的发生无统计学意义(P<0.396)。
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引用次数: 0
Role of dialysate sodium and serum sodium gradient in intradialytic hypertension of regular hemodialysis patients 透析液钠和血清钠梯度在常规血液透析患者分析性高血压中的作用
Pub Date : 2022-01-01 DOI: 10.4103/azmj.azmj_84_21
M. Fayed, E. Mohamed, Hindawy Zidan, A. Assem, Moahmed El-Sayed
Background and aim Sodium (Na+) balance largely depends on interdialytic dietary salt intake and intradialytic Na+ removal during hemodialysis (HD) for chronic renal failure cases. To preserve a normal Na+ equilibrium, interdialytic Na+ increase should be filtered during HD. Sodium gradient (Na+ G) is obtained by subtraction of the dialysate Na+ concentration and the patient’s own pre-HD plasma sodium concentration. The aim was to evaluate the role of dialysate and serum Na+ G in patients with intradialytic hypertension (IDH). Patients and methods A cross-sectional observational study was done to evaluate the role of Na+ G in IDH in a cohort of HD patients followed in the dialysis center of Damanhur Fever Hospital. Among 119 prevalent patients on MHD in our center during period from March 2021 to July 2021, we found 26 patients with IDH, so we selected a control group of 26 patients with intradialytic normotension (age and sex matched). So, the study included 52 patients (age and sex matched) who were divided into two groups: group A included 26 patients who were intradialytic normotensive, and group B included 26 patients with IDH. Results A total of 52 patients were included in our final analysis. The sample included patients who are diagnosed with ESRD and under regular HD schedule, with a mean±SD age of 54.4±12.3 years. Comparison of different sodium concentrations revealed that there was no significant difference between pre-dialytic, and postdialytic Na serum levels, along with no difference in sodium gradients, with P values greater than 0.05. Conclusion IDH was not significantly associated with sodium gradient, age, sex, hemoglobin level, and predialytic and postdialytic serum sodium concentrations.
背景和目的慢性肾衰竭患者血液透析(HD)期间,钠(Na+)平衡在很大程度上取决于透析间期膳食盐摄入量和透析内Na+清除。为了保持正常的Na+平衡,透析期间应过滤透析间期Na+的增加。钠梯度(Na+ G)由透析液钠+浓度和患者自身hd前血浆钠浓度相减得到。目的是评估透析液和血清Na+ G在分析性高血压(IDH)患者中的作用。患者与方法:采用横断面观察研究,评价Na+ G在达曼胡尔发热医院透析中心随访的一组HD患者IDH中的作用。在我中心2021年3月至2021年7月期间的119例MHD流行患者中,我们发现有26例IDH,因此我们选择了26例透析期血压正常(年龄和性别匹配)的患者作为对照组。因此,本研究纳入52例患者(年龄和性别相匹配),分为两组:A组26例透析内血压正常患者,B组26例IDH患者。结果52例患者纳入我们的最终分析。样本包括诊断为ESRD且HD计划正常的患者,平均±SD年龄为54.4±12.3岁。不同钠浓度比较,透析前、透析后血清钠水平差异无统计学意义,钠梯度差异无统计学意义,P值均大于0.05。结论IDH与钠梯度、年龄、性别、血红蛋白水平、透析前和透析后血清钠浓度无显著相关。
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引用次数: 0
Two nitazoxanide-based quadruple regimens for eradication of Helicobacter pylori infection: a single-center randomized controlled trial 两种以硝唑昔酮为基础的四联疗法根除幽门螺杆菌感染:单中心随机对照试验
Pub Date : 2022-01-01 DOI: 10.4103/azmj.azmj_74_21
Amro M. Hassan, K. Eid, K. Eliwa, M. Abdel-Gawad
Background and aim Eradication of Helicobacter pylori becomes an ongoing challenge worldwide because eradication rates of H. pylori are declining to less than 60% in some countries. As there is no acceptable definite long-standing used therapeutic regimen for H. pylori, clinicians are doing their best to find new regimens to improve eradication rates of H. pylori. Nitazoxanid and fluoroquinolones, including moxifloxacin and levofloxacin, have been used in treatment of H. pylori. The study aimed to assess and compare the efficacy of two nitazoxanide-based quadruple regimens in treatment of patients infected with H. pylori. Patients and methods This prospective randomized controlled trial was conducted on 100 patients diagnosed to be infected by H. pylori by stool antigen test (one-step H. pylori Antigen test Device). They were randomized into two groups: group 1: 50 patients were treated for 14 days with quadruple therapy, including nitazoxanide, moxifloxacin, omeprazole, and doxycycline; and group 2: 50 patients were treated for 14 days with quadruple therapy, including nitazoxanide, levofloxacin, omeprazole, and doxycycline. Eradication of H. pylori was assessed 4 weeks after the end of treatment by stool antigen test (one-step H. pylori Antigen test Device). Results Eradication rate of H. pylori infection was higher in patients treated with nitazoxanide–moxifloxacin-based quadruple therapy 37 (74%) than in patients treated with nitazoxanide–levofloxacin-based quadruple therapy 32 (64%), but there were no significant differences between the studied groups with P value (P<0.28). By subgroup analysis of eradication rate among anemic and nonanemic patients treated by nitazoxanide–moxifloxacin and nitazoxanide–levofloxacin-based quadruple therapy, we found that eradication rate was higher in anemic patients 88% and 80% than nonanemic patients 60% and 45%, with significant P values 0.02 and 0.01, respectively. Conclusions Use of moxifloxacin instead of levofloxacin in the nitazoxanide-based quadruple regimen improves eradication therapy of H. pylori.
背景和目的根除幽门螺杆菌在世界范围内成为一项持续的挑战,因为在一些国家,幽门螺杆菌的根除率正在下降到60%以下。由于没有可接受的明确的长期使用的幽门螺杆菌治疗方案,临床医生正在尽最大努力寻找新的方案来提高幽门螺杆菌的根除率。硝唑烷和氟喹诺酮类药物,包括莫西沙星和左氧氟沙星,已被用于治疗幽门螺杆菌。该研究旨在评估和比较两种基于硝唑嗪的四重方案治疗幽门螺杆菌感染患者的疗效。患者和方法本前瞻性随机对照试验采用粪便抗原试验(一步法幽门螺杆菌抗原试验装置)对100例诊断为幽门螺杆菌感染的患者进行研究。他们被随机分为两组:第1组:50名患者接受为期14天的四重治疗,包括硝唑嗪、莫西沙星、奥美拉唑和多西环素;第2组:50例患者采用硝唑嗪、左氧氟沙星、奥美拉唑和多西环素三联疗法治疗14天。在治疗结束后4周,通过粪便抗原测试(一步幽门螺杆菌抗原测试装置)评估幽门螺杆菌的根除情况。结果以硝唑嗪-莫西沙星为基础的三联疗法37例(74%)的幽门螺杆菌根除率高于以硝唑烷-左氧氟沙星为基础的四联疗法32例(64%),但两组间P值无显著性差异(P<0.28)。通过对以硝唑嗪-莫西沙星和硝唑嗪/左氧氟沙星为基础的三联疗法治疗贫血和非贫血患者的根除率进行亚组分析,发现贫血患者88%和80%的根除率高于非贫血患者60%和45%,P值分别为0.02和0.01。结论在以硝唑嗪为基础的四重方案中使用莫西沙星代替左氧氟沙星可以改善幽门螺杆菌的根除治疗。
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引用次数: 0
Need for a digital framework to manage infodemic for better mental health among elderly 需要一个数字框架来管理信息,以改善老年人的心理健康
Pub Date : 2022-01-01 DOI: 10.4103/azmj.azmj_120_21
Nilofur Banu
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引用次数: 0
Postoperative pulmonary embolism, risk factors, and medical thromboprophylaxis: a 2-year retrospective study 术后肺栓塞、危险因素和药物血栓预防:一项2年回顾性研究
Pub Date : 2022-01-01 DOI: 10.4103/azmj.azmj_67_21
Eman Sobh, Maisa A Abdel Wahab, Zeinab R. Adawy, Heba Abdelgalil, Ola I. Saleh, D. Zakaria, Randa S. Elshahat
Background and aim The major surgical procedures have a significant risk of venous thromboembolism (VTE), especially pulmonary embolism (PE), leading to poor prognosis and life-threatening conditions. The major surgical procedure has 20-fold risk increase in VTE and the risk is increased by 30% in the absence of optimal prophylaxis. This study aimed to estimate the incidence of PE among surgical patients undergoing preoperative thromboprophylaxis according to Caprini score, these considerations can improve the clinical outcome and allow optimal use of thromboprophylactic strategies against VTE. Patients and methods We performed retrospective analysis of records of patients admitted to surgical wards at our hospital and identified those who developed postoperative PE. We calculated Caprini score to assess the risk for VTE. Results Among patients admitted to surgical wards, we identified 107 cases of postoperative PE. Most of them had major surgeries, most of them were females, and a considerable proportion of those who developed PE did not receive thromboprophylaxis although being at moderate or high risk for VTE according to Caprini score. Few patients had poor outcome. Conclusion Perioperative thromboprophylaxis is crucial to avoid complication with VTE. Caprini score may be a good clinical score to decide which patients to receive perioperative thromboprophylaxis.
背景和目的主要外科手术有发生静脉血栓栓塞(VTE),特别是肺栓塞(PE)的显著风险,导致预后不良和危及生命。主要的外科手术使VTE的风险增加了20倍,在没有最佳预防措施的情况下,风险增加了30%。本研究旨在根据Caprini评分来评估接受术前血栓预防的外科患者中PE的发生率,这些考虑因素可以改善临床结果,并允许针对VTE最佳使用血栓预防策略。患者和方法我们对我院外科病房的患者记录进行了回顾性分析,并确定了术后发生PE的患者。我们计算了Caprini评分来评估VTE的风险。结果在外科病房收治的患者中,我们发现了107例术后PE。他们中的大多数都进行了大手术,其中大多数是女性。根据Caprini评分,尽管VTE的中高风险,但有相当一部分PE患者没有接受血栓预防。很少有患者出现不良结果。结论围手术期血栓预防是避免VTE并发症的关键。Caprini评分可能是一个很好的临床评分,可以决定哪些患者接受围手术期血栓预防。
{"title":"Postoperative pulmonary embolism, risk factors, and medical thromboprophylaxis: a 2-year retrospective study","authors":"Eman Sobh, Maisa A Abdel Wahab, Zeinab R. Adawy, Heba Abdelgalil, Ola I. Saleh, D. Zakaria, Randa S. Elshahat","doi":"10.4103/azmj.azmj_67_21","DOIUrl":"https://doi.org/10.4103/azmj.azmj_67_21","url":null,"abstract":"Background and aim The major surgical procedures have a significant risk of venous thromboembolism (VTE), especially pulmonary embolism (PE), leading to poor prognosis and life-threatening conditions. The major surgical procedure has 20-fold risk increase in VTE and the risk is increased by 30% in the absence of optimal prophylaxis. This study aimed to estimate the incidence of PE among surgical patients undergoing preoperative thromboprophylaxis according to Caprini score, these considerations can improve the clinical outcome and allow optimal use of thromboprophylactic strategies against VTE. Patients and methods We performed retrospective analysis of records of patients admitted to surgical wards at our hospital and identified those who developed postoperative PE. We calculated Caprini score to assess the risk for VTE. Results Among patients admitted to surgical wards, we identified 107 cases of postoperative PE. Most of them had major surgeries, most of them were females, and a considerable proportion of those who developed PE did not receive thromboprophylaxis although being at moderate or high risk for VTE according to Caprini score. Few patients had poor outcome. Conclusion Perioperative thromboprophylaxis is crucial to avoid complication with VTE. Caprini score may be a good clinical score to decide which patients to receive perioperative thromboprophylaxis.","PeriodicalId":7711,"journal":{"name":"Al-Azhar Assiut Medical Journal","volume":"20 1","pages":"60 - 66"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43739364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A comparative study between magnesium sulfate and dexmedetomidine as adjuvants to bupivacaine using ultrasound-guided lumbar-plexus block in lower abdominal surgeries 超声引导腰丛阻滞下腹部手术中辅助布比卡因的硫酸镁与右美托咪定的比较研究
Pub Date : 2022-01-01 DOI: 10.4103/azmj.azmj_100_21
Mahmoud AbdAlsalam, Nayera Mohamed
Background and aim Pain international association of described pain as an unpleasant sensory and emotional practice accompanied with actual or potential tissue injuries. Opioid administrations remain the cornerstone of postoperative pain relief, but it may cause significant side effects, including sedations, nausea, vomiting, and urinary retention. We aimed to compare the efficacy of ultrasound-guided lumbar-plexus block through adding magnesium sulfate and dexmedetomidine (DEX) to bupivacaine on postoperative analgesia and thereafter surgical operation. Patients and methods This prospective, randomized, double-blinded, controlled research was performed on Al-Azhar University Hospitals. A total of 75 cases of both sexes, age between 21 and 65 years, American Society of Anesthesiologists class I– II, were listed for elective lower-abdomen surgical operation underneath general anesthesia. Results Pain scores were decreased significantly in the study groups for 12 and 18 h in BM and BD, respectively, also, there was a significant decrease at 2, 4, 6, 8, and 12 h in the BD group lesser than the BM group postoperatively. The time to the initial analgesic appeal was significantly extended in the BD group (11.9±1 h) than the BM group (10.6±0.7 h). Conclusion Posterior lumbar-plexus block utilizing 22 ml of bupivacaine 0.5% with DEX 1 μg/kg decreases pain score, opioid consumption, prolongs duration of analgesia, better hemodynamics stability, and perfect outcome of cases’ satisfaction postoperatively compared with posterior lumbar-plexus block using 22 ml of bupivacaine 0.5% with magnesium sulfate 150 mg. DEX provides faster onset time and longer periods of MB and extended period of analgesia with smaller consumptions of postoperative rescue analgesia.
背景和目的国际疼痛协会将疼痛描述为伴随实际或潜在的组织损伤的一种不愉快的感觉和情感实践。阿片类药物仍然是术后疼痛缓解的基石,但它可能引起严重的副作用,包括镇静、恶心、呕吐和尿潴留。我们的目的是通过在布比卡因中加入硫酸镁和右美托咪定(DEX),比较超声引导下腰丛阻滞对术后镇痛和术后手术的效果。患者和方法本前瞻性、随机、双盲、对照研究在爱资哈尔大学附属医院进行。选择全麻下腹部择期外科手术75例,男女皆可,年龄21 ~ 65岁,美国麻醉师学会I ~ II级。结果BM组和BD组分别在术后12、18 h疼痛评分明显下降,且BD组术后2、4、6、8、12 h疼痛评分明显低于BM组。BD组达到初始镇痛效果的时间(11.9±1 h)明显长于BM组(10.6±0.7 h)。结论与0.5%布比卡因22 ml加硫酸镁150 mg后路腰丛阻滞相比,0.5%布比卡因22 ml加DEX 1 μg/kg后路腰丛阻滞可降低疼痛评分,减少阿片类药物消耗,延长镇痛时间,血流动力学稳定性更好,术后患者满意度更好。DEX起效时间快,MB时间长,镇痛时间延长,术后抢救镇痛用量小。
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引用次数: 2
Evaluation of serum sodium levels and mean platelet volume in children with community-acquired pneumonia 社区获得性肺炎患儿血清钠水平和血小板平均体积的评价
Pub Date : 2022-01-01 DOI: 10.4103/AZMJ.AZMJ_40_19
A. Hamed, Mohamed Ibrahim, Hamada Fayed, Mona Mohamed Abd EL-Meguid, S. Hassen
Background and aim Community-acquired pneumonia (CAP) is one of the frequent causes of hospital admission, whereas hyponatremia (HN) is a common electrolyte abnormality in hospitalized patients and is associated with considerable morbidity and mortality. Mean platelet volume (MPV) may be a useful predictor for the diagnosis of CAP but not in disease severity. The purpose of this study was to evaluate serum levels of sodium and MPV in a child with CAP. Patients and methods This is a case–control study that has been carried out in a Malawi General Hospital. The total (100) participants included in the study were classified into two groups as follows: group I which is the case group included 50 children with clinical and laboratory evidence of pneumonia ranging from 1 month to 3 years. Group II which is the control group included 50 children (apparently healthy control) who attended for nonchest problem or serious medical condition. Serum sodium levels, hemoglobin levels, MPV, platelet count, total leukocyte count, and C-reactive protein were done to all children. Results HN was present in 82% of patients with CAP (41 out of 50). Patients with CAP had lower MPV than their healthy counterparts (7.11±0.42 vs. 9.14±1.04 fl; P<0.001). There was a statistically significant negative correlation between the grade of respiratory distress and the level of serum sodium and a positive correlation between the grade of respiratory distress and MPV (P<0.001). Conclusion HN is common among hospitalized children with CAP and MPV may be a useful predictor for the diagnosis of CAP.
背景和目的社区获得性肺炎(CAP)是住院的常见原因之一,而低钠血症(HN)是住院患者常见的电解质异常,与相当大的发病率和死亡率有关。平均血小板体积(MPV)可能是诊断CAP的有用预测指标,但不是疾病严重程度的预测指标。本研究的目的是评估CAP患儿的血清钠和MPV水平。患者和方法这是一项在马拉维综合医院进行的病例对照研究。纳入研究的总共(100)名参与者分为两组,如下:第一组为病例组,包括50名有1个月至3岁肺炎临床和实验室证据的儿童。第二组为对照组,包括50名因非严重问题或严重疾病就诊的儿童(明显为健康对照组)。对所有儿童进行血清钠水平、血红蛋白水平、MPV、血小板计数、白细胞总数和C反应蛋白检测。结果82%的CAP患者(41例)存在HN。CAP患者的MPV低于健康对照组(7.11±0.42 vs.9.14±1.04 fl;P<0.001)。呼吸窘迫程度与血清钠水平呈显著负相关,呼吸窘迫程度和MPV呈正相关(P<0.01)是诊断CAP的有用预测因子。
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引用次数: 0
Psychological burden of coronavirus disease 2019 pandemic among Egyptian pregnant women 2019冠状病毒病大流行对埃及孕妇的心理负担
Pub Date : 2022-01-01 DOI: 10.4103/azmj.azmj_133_21
Hala Halim, Shimaa Abd Elaziz, Doaa Fathy
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引用次数: 0
Worsening of the hypertension crisis during coronavirus disease 2019 pandemic − are we ready? 2019冠状病毒病大流行期间高血压危机恶化——我们准备好了吗?
Pub Date : 2022-01-01 DOI: 10.4103/azmj.azmj_7_22
S. Bakshi, V. Kalidoss
{"title":"Worsening of the hypertension crisis during coronavirus disease 2019 pandemic − are we ready?","authors":"S. Bakshi, V. Kalidoss","doi":"10.4103/azmj.azmj_7_22","DOIUrl":"https://doi.org/10.4103/azmj.azmj_7_22","url":null,"abstract":"","PeriodicalId":7711,"journal":{"name":"Al-Azhar Assiut Medical Journal","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70690812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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Al-Azhar Assiut Medical Journal
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