Pub Date : 2024-05-05DOI: 10.21608/adjalexu.2023.215437.1385
Hussein Zeidan, Nevein Mohamed, Dina Nader
BACKGROUND: One of the most common minor surgeries in dental practices is the surgical removal of impacted third molars; a procedure that requires optimum physical and radiological assessment to decrease the complications that may arise during the procedure. Certain surgical modalities have been proposed to decrease the invasiveness of the procedure, one is the diode laser therapeutic use. OBJECTIVES: To clinically compare the wound healing rate and the clinical outcome that occurs following the surgical removal of impacted third molar teeth by the conventional gold standard scalpel versus the diode laser incision in diabetic patients. MATERIALS AND METHODS: The study was a split-mouth randomized clinical trial. Twenty-three diabetic patients who needed bilateral surgical removal of impacted mandibular third molar were recruited and randomized. One side (study group) had the incision undergone by the diode laser, while the contralateral side (control group) had the conventional scalpel incision to expose the tooth. Pain was recorded by Visual analogue scale (VAS) after one and seven days, edema was measured by three facial lines after one and seven days, trismus was recorded by measuring the inter-incisal opening after seven days and one month and the wound healing was recorded by the Early wound healing scale (EHS) after seven days and one month postoperative. RESULTS: The clinical outcome showed statistically significant differences in pain, edema, and trismus in the study group, while the control group showed statistically significant differences in wound healing in the early postoperative period, however, a non-significant difference was noted between both groups after one-month follow-up. CONCLUSION: Diode laser incision was an efficient procedure in decreasing the post-operative pain, trismus and edema following removal of impacted third molars. The only disadvantage was delayed wound healing in the first week
{"title":"COMPARISON OF DIODE LASER VERSUS CONVENTIONAL SCALPEL INCISION IN REMOVAL OF IMPACTED LOWER THIRD MOLAR IN DIABETIC PATIENTS (A SPLIT MOUTH RANDOMIZED CONTROLLED CLINICAL TRIAL)","authors":"Hussein Zeidan, Nevein Mohamed, Dina Nader","doi":"10.21608/adjalexu.2023.215437.1385","DOIUrl":"https://doi.org/10.21608/adjalexu.2023.215437.1385","url":null,"abstract":"BACKGROUND: One of the most common minor surgeries in dental practices is the surgical removal of impacted third molars; a procedure that requires optimum physical and radiological assessment to decrease the complications that may arise during the procedure. Certain surgical modalities have been proposed to decrease the invasiveness of the procedure, one is the diode laser therapeutic use. OBJECTIVES: To clinically compare the wound healing rate and the clinical outcome that occurs following the surgical removal of impacted third molar teeth by the conventional gold standard scalpel versus the diode laser incision in diabetic patients. MATERIALS AND METHODS: The study was a split-mouth randomized clinical trial. Twenty-three diabetic patients who needed bilateral surgical removal of impacted mandibular third molar were recruited and randomized. One side (study group) had the incision undergone by the diode laser, while the contralateral side (control group) had the conventional scalpel incision to expose the tooth. Pain was recorded by Visual analogue scale (VAS) after one and seven days, edema was measured by three facial lines after one and seven days, trismus was recorded by measuring the inter-incisal opening after seven days and one month and the wound healing was recorded by the Early wound healing scale (EHS) after seven days and one month postoperative. RESULTS: The clinical outcome showed statistically significant differences in pain, edema, and trismus in the study group, while the control group showed statistically significant differences in wound healing in the early postoperative period, however, a non-significant difference was noted between both groups after one-month follow-up. CONCLUSION: Diode laser incision was an efficient procedure in decreasing the post-operative pain, trismus and edema following removal of impacted third molars. The only disadvantage was delayed wound healing in the first week","PeriodicalId":7723,"journal":{"name":"Alexandria Dental Journal","volume":"52 3S","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141011663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-05DOI: 10.21608/adjalexu.2024.241416.1419
Hend Abdulkader, Maha Abou Khadr, Ghada Bassiouny, Samia Soliman
BACKGROUND: Viability of the harvested bone during osteotomy preparation is affected by the generated heat, which in turn is related to drilling speed and time; this bone viability is considered an indicator of the quality of the harvested autograft. STUDY OBJECTIVE: The aim of this study was to assess the effect of two different drilling speeds on bone cell viability of bone harvested during osteotomy preparation. MATERIALS AND METHODS: A split mouth randomized controlled clinical trial was carried out on 8 patients, 16 mandibular premolar /molar edentulous ridge sites, using a trephine bur, 8 osteotomies were drilled using a speed of 1000 rpm (Control Group) and the other 8 using 400 rpm (Test Group), implants were placed, the harvested bone viability was evaluated histologically in both groups. RESULTS: The histological assessment revealed better viability features in samples harvested using 1000 rpm (Control Group). CONCLUSION: Drilling at 1000 rpm seems to yield stronger autologous bone viability than drilling at 400 rpm.
{"title":"ASSESSMENT OF BONE CELL VIABILITY IN BONE HARVESTED UNDER TWO DIFFERENT DRILLING SPEEDS DURING IMPLANT BED PREPARATION IN THE MANDIBULAR POSTERIOR SITES (A RANDOMIZED CONTROLLED CLINICAL TRIAL)","authors":"Hend Abdulkader, Maha Abou Khadr, Ghada Bassiouny, Samia Soliman","doi":"10.21608/adjalexu.2024.241416.1419","DOIUrl":"https://doi.org/10.21608/adjalexu.2024.241416.1419","url":null,"abstract":"BACKGROUND: Viability of the harvested bone during osteotomy preparation is affected by the generated heat, which in turn is related to drilling speed and time; this bone viability is considered an indicator of the quality of the harvested autograft. STUDY OBJECTIVE: The aim of this study was to assess the effect of two different drilling speeds on bone cell viability of bone harvested during osteotomy preparation. MATERIALS AND METHODS: A split mouth randomized controlled clinical trial was carried out on 8 patients, 16 mandibular premolar /molar edentulous ridge sites, using a trephine bur, 8 osteotomies were drilled using a speed of 1000 rpm (Control Group) and the other 8 using 400 rpm (Test Group), implants were placed, the harvested bone viability was evaluated histologically in both groups. RESULTS: The histological assessment revealed better viability features in samples harvested using 1000 rpm (Control Group). CONCLUSION: Drilling at 1000 rpm seems to yield stronger autologous bone viability than drilling at 400 rpm.","PeriodicalId":7723,"journal":{"name":"Alexandria Dental Journal","volume":"283 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141012254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-05DOI: 10.21608/adjalexu.2023.207470.1371
Rawan Tammam, Samraa A. Elsheikh, Marwa G. Noureldin, Hayam Abdel-Ghani
INTRODUCTION: Mandibular fractures are considered a significant percentage of maxillofacial trauma. Multiple techniques, have been used to improve mandibular fracture healing over the years. Low Intensity Pulsed Ultrasound (LIPUS) has recently been used in orthopaedic surgery for improvement of bone union, but was rarely investigated for facial bones. OBJECTIVE: The aim is to compare the efficacy of the use of LIPUS in accelerating bone healing of jaw fractures after open reduction versus the use of conventional miniplates only, investigated both radiographically and clinically. MATERIALS AND METHODS: In an interventional study, 18 cases with jaw fractures were assigned to two groups at random: the study group and the control group, having 9 participants in each group. Both groups underwent open reduction and internal fixation using two conventional miniplates but only the study group received LIPUS stimulation (1.5MHz, 30W/cm2) for 20 minutes on postoperative days 4, 8, 14 and 20. The control group did not receive LIPUS. Clinical evaluation included wound healing, occlusion and pain intensity. Radiographic evaluation using immediate Cone Beam Computerized Tomography (CBCT) and postoperative CBCT after 12 weeks were used to determine the efficacy by measuring various variables, including bone density and radiographic fracture healing. Results After twelve weeks, both groups had normal occlusion and normal sensory function. The wound healing was measured using landry’s score index, there was a significant difference in both groups along the follow up period (p<0.001) and a statistically significant reduction in pain intensity (p<0.001). The average bone density improved statistically significantly in both groups A (p<0.001) and B (p<0.001) when comparing post-operative 12 week values to preoperative values. CONCLUSION: Based on the favourable clinical and acceptable radiographical outcomes of our study, it is concluded that the application of low intensity pulsed ultrasound in mandibular fractures could potentially speed up the healing process, decrease the pain and postoperative complications.
{"title":"AN EVALUATION OF THE EFFECT OF LOW INTENSITY PULSED ULTRASOUND ON THE HEALING OF MANDIBULAR FRACTURES A RANDOMIZED CLINICAL TRIAL","authors":"Rawan Tammam, Samraa A. Elsheikh, Marwa G. Noureldin, Hayam Abdel-Ghani","doi":"10.21608/adjalexu.2023.207470.1371","DOIUrl":"https://doi.org/10.21608/adjalexu.2023.207470.1371","url":null,"abstract":"INTRODUCTION: Mandibular fractures are considered a significant percentage of maxillofacial trauma. Multiple techniques, have been used to improve mandibular fracture healing over the years. Low Intensity Pulsed Ultrasound (LIPUS) has recently been used in orthopaedic surgery for improvement of bone union, but was rarely investigated for facial bones. OBJECTIVE: The aim is to compare the efficacy of the use of LIPUS in accelerating bone healing of jaw fractures after open reduction versus the use of conventional miniplates only, investigated both radiographically and clinically. MATERIALS AND METHODS: In an interventional study, 18 cases with jaw fractures were assigned to two groups at random: the study group and the control group, having 9 participants in each group. Both groups underwent open reduction and internal fixation using two conventional miniplates but only the study group received LIPUS stimulation (1.5MHz, 30W/cm2) for 20 minutes on postoperative days 4, 8, 14 and 20. The control group did not receive LIPUS. Clinical evaluation included wound healing, occlusion and pain intensity. Radiographic evaluation using immediate Cone Beam Computerized Tomography (CBCT) and postoperative CBCT after 12 weeks were used to determine the efficacy by measuring various variables, including bone density and radiographic fracture healing. Results After twelve weeks, both groups had normal occlusion and normal sensory function. The wound healing was measured using landry’s score index, there was a significant difference in both groups along the follow up period (p<0.001) and a statistically significant reduction in pain intensity (p<0.001). The average bone density improved statistically significantly in both groups A (p<0.001) and B (p<0.001) when comparing post-operative 12 week values to preoperative values. CONCLUSION: Based on the favourable clinical and acceptable radiographical outcomes of our study, it is concluded that the application of low intensity pulsed ultrasound in mandibular fractures could potentially speed up the healing process, decrease the pain and postoperative complications.","PeriodicalId":7723,"journal":{"name":"Alexandria Dental Journal","volume":"296 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141012463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-05DOI: 10.21608/adjalexu.2023.206918.1370
Ahmed Ramadan, Yousria Shalaby, Naguib El fawal
INTRODUCTION: The accuracy of impressions has an important effect on the marginal adaptation of fixed restorations. Fit is the most significant factor influencing the restoration's durability, retention, and periodontal health. AIM OF STUDY: to compare the marginal fit of CAD/CAM zirconia crowns manufactured using two distinct digital impression techniques. MATERIALS AND METHODS: A typodont tooth in the upper premolar region was prepared to receive a full ceramic crown. A direct scan of the prepared tooth was used to create twenty 3D-printed resin dies. The master dies were divided into two groups at random (n = 10 per group). Group I: scanning the dies digitally. Group II: Digitization of the silicone, scannable impressions. Using cone beam CT, the vertical and horizontal marginal gap were evaluated. RESULTS: Group I had a vertical marginal gap of (119.5 ± 27.0) µm, which was substantially smaller than Group II's (144.8 ± 25.23) µm, and a horizontal marginal gap of (107.5 ± 36.36) µm, which was smaller than Group II's (154.3 ± 49.53) µm. CONCLUSION: Although direct digital scanning was superior to indirect digital scanning in terms of marginal fit, all tested techniques yielded clinically acceptable fit values.
{"title":"MARGINAL FIT ASSESSMENT OF CAD/CAM ZIRCONIA CROWNS FABRICATED BY DIGITAL SCANNING OF DIES AND SILICONE IMPRESSION (IN VITRO STUDY)","authors":"Ahmed Ramadan, Yousria Shalaby, Naguib El fawal","doi":"10.21608/adjalexu.2023.206918.1370","DOIUrl":"https://doi.org/10.21608/adjalexu.2023.206918.1370","url":null,"abstract":"INTRODUCTION: The accuracy of impressions has an important effect on the marginal adaptation of fixed restorations. Fit is the most significant factor influencing the restoration's durability, retention, and periodontal health. AIM OF STUDY: to compare the marginal fit of CAD/CAM zirconia crowns manufactured using two distinct digital impression techniques. MATERIALS AND METHODS: A typodont tooth in the upper premolar region was prepared to receive a full ceramic crown. A direct scan of the prepared tooth was used to create twenty 3D-printed resin dies. The master dies were divided into two groups at random (n = 10 per group). Group I: scanning the dies digitally. Group II: Digitization of the silicone, scannable impressions. Using cone beam CT, the vertical and horizontal marginal gap were evaluated. RESULTS: Group I had a vertical marginal gap of (119.5 ± 27.0) µm, which was substantially smaller than Group II's (144.8 ± 25.23) µm, and a horizontal marginal gap of (107.5 ± 36.36) µm, which was smaller than Group II's (154.3 ± 49.53) µm. CONCLUSION: Although direct digital scanning was superior to indirect digital scanning in terms of marginal fit, all tested techniques yielded clinically acceptable fit values.","PeriodicalId":7723,"journal":{"name":"Alexandria Dental Journal","volume":"7 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141011837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-05DOI: 10.21608/adjalexu.2023.225905.1406
Asmaa Ezzat, Riham M El Dibany, Mohamed Shokry, Yasser Helmy
BACKGROUND: One of the most frequent facial fractures is an orbital fracture, and multiple wall restoration is frequently required following high-energy trauma. Correct planning, thorough surgical dissection, and appropriate selection of the kind, size, and shape of the reconstruction material are all necessary for a successful outcome. The appropriate material to use to restore the orbital floor and walls is still up for debate. For that aim, numerous materials have been described from various sources. The ultimate goals involve treating the bony orbital deficiency while restoring anatomy, volume, function, and esthetics. While each type of material has benefits and drawbacks, the ability to fulfill those. AIM OF THE STUDY: This study evaluated the difference in the bone density after orbital floor fracture reconstruction with titanium mesh coated with natural nanohydroxyapatite by electrophoretic deposition versus conventional titanium mesh. PATIENTS & METHODS: This study was carried out clinically on 12 adult patients with fractures of the orbital floor that should be treated with internal fixation and open reduction. The patients were divided into 2 groups, (group A): patients where the reconstruction was done using coated titanium mesh with hydroxyapatite nanocrystals and (group B): the repair and reconstruction of the defect was using conventional titanium mesh. RESULTS: The radiographic differences in bone density between the study and control groups were statistically significant. CONCLUSION: The ongoing study displayed better bone density outcomes in reconstructed orbital floor defects with coated titanium mesh when compared to uncoated titanium mesh.
{"title":"TITANIUM MESH COATED WITH NATURAL HYDROXYAPATITE NANOCRYSTALS IN ORBITAL RECONSTRUCTION (RANDOMIZED CONTROLLED CLINICAL TRIAL)","authors":"Asmaa Ezzat, Riham M El Dibany, Mohamed Shokry, Yasser Helmy","doi":"10.21608/adjalexu.2023.225905.1406","DOIUrl":"https://doi.org/10.21608/adjalexu.2023.225905.1406","url":null,"abstract":"BACKGROUND: One of the most frequent facial fractures is an orbital fracture, and multiple wall restoration is frequently required following high-energy trauma. Correct planning, thorough surgical dissection, and appropriate selection of the kind, size, and shape of the reconstruction material are all necessary for a successful outcome. The appropriate material to use to restore the orbital floor and walls is still up for debate. For that aim, numerous materials have been described from various sources. The ultimate goals involve treating the bony orbital deficiency while restoring anatomy, volume, function, and esthetics. While each type of material has benefits and drawbacks, the ability to fulfill those. AIM OF THE STUDY: This study evaluated the difference in the bone density after orbital floor fracture reconstruction with titanium mesh coated with natural nanohydroxyapatite by electrophoretic deposition versus conventional titanium mesh. PATIENTS & METHODS: This study was carried out clinically on 12 adult patients with fractures of the orbital floor that should be treated with internal fixation and open reduction. The patients were divided into 2 groups, (group A): patients where the reconstruction was done using coated titanium mesh with hydroxyapatite nanocrystals and (group B): the repair and reconstruction of the defect was using conventional titanium mesh. RESULTS: The radiographic differences in bone density between the study and control groups were statistically significant. CONCLUSION: The ongoing study displayed better bone density outcomes in reconstructed orbital floor defects with coated titanium mesh when compared to uncoated titanium mesh.","PeriodicalId":7723,"journal":{"name":"Alexandria Dental Journal","volume":"299 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141012443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-05DOI: 10.21608/adjalexu.2023.226031.1408
Mohammad Zeid, Saeeda Osman, Dina Metawie
BACKGROUND: Narrow ridges can cause difficulties in restoring function by dental implants; many techniques can be used to overcome this problem such as bone grafting and ridge expansion techniques, with ridge expansion being the better, more reliable option. A recent technique that can achieve ridge expansion is osseodensification. Osseodensification using Densah burs is a technique that condenses bone using specially designed burs rotating in an anticlockwise direction, which will help in increasing the ridge width as well as insertion torque of the implant AIM OF THIS STUDY: Clinical and Radiographic evaluation of ridge expansion in posterior atrophic mandible using osseodensification with simultaneous implant placement. MATERIALS AND METHODS: 12 patients with narrow posterior mandibular ridge with width ≤ 6 mm received implants using osseodensification technique. The amount of ridge expansion, primary and secondary stability at 4 months and marginal bone loss were evaluated at 4 and 8 months. RESULTS: 4 months post-operative bone width was increased by 43.61% and after 8 months bone width was increased by 39.29% in the cervical region and increased by 11.48% at 4 months and 9.89% at 8 months in the middle region and increased by 12.64% at 4 months and 10.57% at 8 months in the apical region. There was also a significant increase in bone density around the implants (p ≤ 0.05) CONCLUSION: Based on the results of this study we concluded that osseodensification is a safe and effective way for expanding narrow posterior alveolar ridges, while increasing bone density around the implant which positively affects the primary and secondary stability; without complications such as dehiscences and fractures of the buccal plate of bone.
{"title":"HORIZONTAL ALVEOLAR RIDGE EXPANSION IN POSTERIOR ATROPHIC MANDIBLE USING OSSEODENSIFICATION TECHNIQUE (A CLINICAL TRIAL)","authors":"Mohammad Zeid, Saeeda Osman, Dina Metawie","doi":"10.21608/adjalexu.2023.226031.1408","DOIUrl":"https://doi.org/10.21608/adjalexu.2023.226031.1408","url":null,"abstract":"BACKGROUND: Narrow ridges can cause difficulties in restoring function by dental implants; many techniques can be used to overcome this problem such as bone grafting and ridge expansion techniques, with ridge expansion being the better, more reliable option. A recent technique that can achieve ridge expansion is osseodensification. Osseodensification using Densah burs is a technique that condenses bone using specially designed burs rotating in an anticlockwise direction, which will help in increasing the ridge width as well as insertion torque of the implant AIM OF THIS STUDY: Clinical and Radiographic evaluation of ridge expansion in posterior atrophic mandible using osseodensification with simultaneous implant placement. MATERIALS AND METHODS: 12 patients with narrow posterior mandibular ridge with width ≤ 6 mm received implants using osseodensification technique. The amount of ridge expansion, primary and secondary stability at 4 months and marginal bone loss were evaluated at 4 and 8 months. RESULTS: 4 months post-operative bone width was increased by 43.61% and after 8 months bone width was increased by 39.29% in the cervical region and increased by 11.48% at 4 months and 9.89% at 8 months in the middle region and increased by 12.64% at 4 months and 10.57% at 8 months in the apical region. There was also a significant increase in bone density around the implants (p ≤ 0.05) CONCLUSION: Based on the results of this study we concluded that osseodensification is a safe and effective way for expanding narrow posterior alveolar ridges, while increasing bone density around the implant which positively affects the primary and secondary stability; without complications such as dehiscences and fractures of the buccal plate of bone.","PeriodicalId":7723,"journal":{"name":"Alexandria Dental Journal","volume":"234 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141012992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-05DOI: 10.21608/adjalexu.2024.237539.1415
Esraa Farahat, Shahira El Domiaty, S. Mahmoud, S. Anwar
BACK GROUND: Oral Lichen planus (OLP) is an autoimmune disorder with a chronic nature where CD8+ cytotoxic T-cells release inflammatory cytokines. Inflammations in OLP persist due to matrix metalloproteinases (MMPs) that have a role in collagen cleavage. Zinc prevents basement membrane disruption through inhibition of MMP-9 activation. AIM OF THE STUDY: Evaluating and comparing clinically the effectiveness of adding systemic oral zinc supplementation to topical corticosteroids and topical corticosteroids alone for erosive OLP (EOLP) treatment, and to measure biochemically salivary MMP-9 levels before and after both treatment modalities. METHODOLOGY: This study was performed on 22 patients have EOLP and divided equally into: Test group; 11 patients received oral zinc picolinate 50 mg as a single morning dose with 0.1% triamcinolone acetonide (TA) oral paste twice daily for 6 weeks. Control group; 11 patients received 0.1% TA orabase twice daily for 6 weeks. Patients were recruited and assessed clinically at baseline, after six and twelve weeks using numerical rating scale (NRS) for pain assessment and Thongprasom et al score for objective assessment of oral lesions. Salivary MMP-9 was evaluated at baseline and after 12 weeks. RESULTS: Test group showed a significant lowering in Thongprasom et al score after 6 weeks, a significant reduction in NRS after 6 and 12 weeks, and a significant reduction in MMP-9 levels from baseline to weeks 12 as compared to control group. CONCLUSIONS: Oral zinc supplementation with topical corticosteroids has promising effects for EOLP.
{"title":"EFFICACY OF ORAL ZINC SUPPLEMENT AS AN ADJUNCTIVE THERAPY FOR EROSIVE ORAL LICHEN PLANUS (A RANDOMIZED, CONTROLLED CLINICAL TRIAL)","authors":"Esraa Farahat, Shahira El Domiaty, S. Mahmoud, S. Anwar","doi":"10.21608/adjalexu.2024.237539.1415","DOIUrl":"https://doi.org/10.21608/adjalexu.2024.237539.1415","url":null,"abstract":"BACK GROUND: Oral Lichen planus (OLP) is an autoimmune disorder with a chronic nature where CD8+ cytotoxic T-cells release inflammatory cytokines. Inflammations in OLP persist due to matrix metalloproteinases (MMPs) that have a role in collagen cleavage. Zinc prevents basement membrane disruption through inhibition of MMP-9 activation. AIM OF THE STUDY: Evaluating and comparing clinically the effectiveness of adding systemic oral zinc supplementation to topical corticosteroids and topical corticosteroids alone for erosive OLP (EOLP) treatment, and to measure biochemically salivary MMP-9 levels before and after both treatment modalities. METHODOLOGY: This study was performed on 22 patients have EOLP and divided equally into: Test group; 11 patients received oral zinc picolinate 50 mg as a single morning dose with 0.1% triamcinolone acetonide (TA) oral paste twice daily for 6 weeks. Control group; 11 patients received 0.1% TA orabase twice daily for 6 weeks. Patients were recruited and assessed clinically at baseline, after six and twelve weeks using numerical rating scale (NRS) for pain assessment and Thongprasom et al score for objective assessment of oral lesions. Salivary MMP-9 was evaluated at baseline and after 12 weeks. RESULTS: Test group showed a significant lowering in Thongprasom et al score after 6 weeks, a significant reduction in NRS after 6 and 12 weeks, and a significant reduction in MMP-9 levels from baseline to weeks 12 as compared to control group. CONCLUSIONS: Oral zinc supplementation with topical corticosteroids has promising effects for EOLP.","PeriodicalId":7723,"journal":{"name":"Alexandria Dental Journal","volume":"23 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141012035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-05DOI: 10.21608/adjalexu.2023.201324.1360
Emad Ayad, Maha Abou Khadr, Mona Ayad, Gillan I El-Kimary
BACKGROUND: Clinical parameters are used to diagnose periodontal disease. However, new technical advances in diagnostics for assessing periodontal status are utilizing objective biomarkers. Recently, a number of biomarkers have been identified to predict periodontitis status. Endocan is a novel pro-inflammatory biomarker that is thought to give an insight on periodontal disease status. Objective: Evaluation of Endocan level in gingival crevicular fluid (GCF) of stage 1 and 2 periodontitis patients with or without type 2 diabetes mellitus. MATERIALS AND METHODS: 42 patients with stage 1 and 2 periodontitis were divided into two groups: 23 patients with controlled type 2 diabetes mellitus (CT2DM-P) and 19 systemically healthy periodontitis patients (H-P). Endocan level in GCF, periodontal parameters, and Hemoglobin A1c (HbA1c) value were measured. Biochemical analysis of Endocan level was performed by enzyme-linked immunosorbent assay (ELISA). RESULTS: GCF Endocan level was significantly higher in the CT2DM-P group than in the H-P group. Mean pocket probing depth (PPD), clinical attachment loss (CAL), and bleeding on probing percentage (BOP%) were higher in the CT2DM-P group. Endocan was positively correlated to CAL, BOP%, and HbA1c in both groups, with Endocan and BOP% having a moderate correlation in the CT2DM-P group and Endocan and HbA1c having a strong correlation in the H-P group. CONCLUSION: Endocan levels, PPD, CAL, and BOP% in CT2DM-P group were higher than H-P group. Positive correlations between BOP%, Glycated hemoglobin and Endocan were also observed.
{"title":"ENDOCAN: A NOVEL BIOMARKER IN GINGIVAL CREVICULAR FLUID IN PERIODONTITIS PATIENTS WITH OR WITHOUT TYPE 2 DIABETES MELLITUS [A CROSS-SECTIONAL STUDY]","authors":"Emad Ayad, Maha Abou Khadr, Mona Ayad, Gillan I El-Kimary","doi":"10.21608/adjalexu.2023.201324.1360","DOIUrl":"https://doi.org/10.21608/adjalexu.2023.201324.1360","url":null,"abstract":"BACKGROUND: Clinical parameters are used to diagnose periodontal disease. However, new technical advances in diagnostics for assessing periodontal status are utilizing objective biomarkers. Recently, a number of biomarkers have been identified to predict periodontitis status. Endocan is a novel pro-inflammatory biomarker that is thought to give an insight on periodontal disease status. Objective: Evaluation of Endocan level in gingival crevicular fluid (GCF) of stage 1 and 2 periodontitis patients with or without type 2 diabetes mellitus. MATERIALS AND METHODS: 42 patients with stage 1 and 2 periodontitis were divided into two groups: 23 patients with controlled type 2 diabetes mellitus (CT2DM-P) and 19 systemically healthy periodontitis patients (H-P). Endocan level in GCF, periodontal parameters, and Hemoglobin A1c (HbA1c) value were measured. Biochemical analysis of Endocan level was performed by enzyme-linked immunosorbent assay (ELISA). RESULTS: GCF Endocan level was significantly higher in the CT2DM-P group than in the H-P group. Mean pocket probing depth (PPD), clinical attachment loss (CAL), and bleeding on probing percentage (BOP%) were higher in the CT2DM-P group. Endocan was positively correlated to CAL, BOP%, and HbA1c in both groups, with Endocan and BOP% having a moderate correlation in the CT2DM-P group and Endocan and HbA1c having a strong correlation in the H-P group. CONCLUSION: Endocan levels, PPD, CAL, and BOP% in CT2DM-P group were higher than H-P group. Positive correlations between BOP%, Glycated hemoglobin and Endocan were also observed.","PeriodicalId":7723,"journal":{"name":"Alexandria Dental Journal","volume":"38 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141011553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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