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Diagnostic value of molecular testing for evaluating thyroid nodules greater than 4 centimeters 分子检测对大于4厘米甲状腺结节的诊断价值
IF 2.7 3区 医学 Q1 SURGERY Pub Date : 2025-11-27 DOI: 10.1016/j.amjsurg.2025.116755
Niranjna Swaminathan , ZhiXing Song , Christopher Wu , Ramsha Akhund , Jessica Fazendin , Brenessa Lindeman , Herbert Chen , Andrea Gillis

Background

Molecular testing (MT) aids in reducing unnecessary thyroidectomy for indeterminate thyroid nodules, primarily due to its high negative predictive value (NPV). However, its reliability in large nodules (≥4 ​cm), which carry a higher malignancy risk, remains unclear.

Methods

We performed a retrospective study of patients with thyroid nodules ≥4 ​cm who underwent fine-needle aspiration (FNA) at a tertiary care center from 2015 to 2023. Cytology was categorized using the Bethesda system. Molecular results (Afirma GEC and GSC) were matched with surgical pathology. Noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) was classified as malignant.

Results

A total of 231 patients were included (mean age 52 ​± ​16 years; 69.7 ​% female). The median nodule size was 5.0 ​cm (IQR: 4.4–5.8). Malignancy was identified in 28.1 ​% of cases. Malignancy rates by Bethesda category were 4.3 ​% (Bethesda II), 33.8 ​% (III), and 50.0 ​% (IV), all Bethesda V and VI nodules were malignant. Among 96 patients with Bethesda III or IV cytology, 79 (82.3 ​%) underwent MT, 30 with GEC and 47 with GSC. GEC yielded 91.7 ​% sensitivity, 33.3 ​% specificity, and NPV of 85.7 ​%. GSC showed 88.9 ​% sensitivity, 58.6 ​% specificity, and NPV of 89.5 ​%. Malignancy occurred in 40.0 ​% (GEC) and 38.3 ​% (GSC) of tested nodules. False negatives included anaplastic carcinoma, oncocytic carcinoma, and NIFTP. Mutation testing revealed malignancy in 41.4 ​% of BRAF-negative and 44.8 ​% of RET/PTC-negative patients.

Conclusion

Molecular testing in nodules ≥4 ​cm may underestimate malignancy risk. Clinicians should interpret benign MT results in this subgroup with caution.
分子检测(MT)有助于减少不确定甲状腺结节的不必要的甲状腺切除术,主要是由于其高阴性预测值(NPV)。然而,对于恶性肿瘤风险较高的大结节(≥4cm),其可靠性尚不清楚。方法回顾性分析2015年至2023年在某三级医疗中心接受细针穿刺(FNA)治疗的甲状腺结节≥4 cm患者。细胞学分类采用Bethesda系统。分子结果(Afirma GEC和GSC)与手术病理相符。具有乳头状核特征的非侵袭性甲状腺滤泡性肿瘤(NIFTP)被归类为恶性肿瘤。结果共纳入231例患者,平均年龄52±16岁,女性占69.7%。中位结节大小为5.0 cm (IQR: 4.4-5.8)。恶性肿瘤占28.1%。Bethesda分型的恶性率分别为4.3% (Bethesda II型)、33.8% (Bethesda III型)和50.0% (Bethesda IV型),所有Bethesda V型和VI型结节均为恶性。在96例Bethesda III或IV细胞学检查患者中,79例(82.3%)接受了MT, 30例接受了GEC, 47例接受了GSC。GEC的敏感性为91.7%,特异性为33.3%,NPV为85.7%。GSC的敏感性为88.9%,特异性为58.6%,NPV为89.5%。恶性结节发生率为40.0% (GEC)和38.3% (GSC)。假阴性包括间变性癌、嗜瘤细胞癌和NIFTP。突变检测显示,41.4%的brf阴性患者和44.8%的RET/ ptc阴性患者为恶性肿瘤。结论≥4 cm结节的分子检测可能低估了肿瘤的恶性风险。临床医生应谨慎解释该亚组的良性MT结果。
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引用次数: 0
Diagnostic localization techniques in Primary hyperparathyroidism: Is PET Choline the new gold standard? 原发性甲状旁腺功能亢进的定位诊断技术:PET胆碱是新的金标准吗?
IF 2.7 3区 医学 Q1 SURGERY Pub Date : 2025-11-26 DOI: 10.1016/j.amjsurg.2025.116754
Niranjna Swaminathan, Sanya Nathani, Andrea Gillis, Sophie Dream, Brenessa Lindeman, Herbert Chen, Peter J Abraham
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引用次数: 0
Patients with primary hyperparathyroidism who required three or more parathyroidectomies: Could this be prevented? 原发性甲状旁腺功能亢进症患者需要三次或三次以上的甲状旁腺切除术:这种情况可以预防吗?
IF 2.7 3区 医学 Q1 SURGERY Pub Date : 2025-11-26 DOI: 10.1016/j.amjsurg.2025.116753
Alexandra Savage, Rachael Caretti, Hector Caceres, Madeleine Obuya, Zhixing Song, Sanajana Balachandra, Jessica Fazendin, Brenessa Lindeman, Andrea Gillis, Sophie Dream, Herbert Chen
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引用次数: 0
U.S. mortality in abdominal surgical emergencies: Comparative analysis of obesity-associated vs overall deaths (1999–2020) 美国腹部外科急诊死亡率:1999-2020年肥胖相关死亡与总体死亡的比较分析
IF 2.7 3区 医学 Q1 SURGERY Pub Date : 2025-11-25 DOI: 10.1016/j.amjsurg.2025.116735
Haneen Kamran , Muhammad Umar Bhatti , Sameen Tahira , Umm E. Aimen Minhas , Farah Khan , Muhammad Ahsan Asif , Azeem Khalid , Juaquito Jorge , Kashaf Sherafgan

Background

Obesity increases mortality risk in emergency abdominal surgery patients, yet large-scale, population-level analyses remain scarce.

Methods

This study analyzed U.S. mortality trends (1999–2020) from the CDC WONDER database, assessing mortality both overall and in obese patients with acute abdominal surgical emergencies (ASE) using ICD-10 codes. Age-adjusted mortality rates (AAMRs) and annual percent changes (APCs) were calculated.

Results

Obesity-related ASE AAMR rose significantly from 2.05 to 5.5 per million, with a marked increase post-2018 (APC ​= ​23.42). Mortality was higher in women but increased faster in men in the obesity group in contrast to higher ASE related mortality in males overall. Significant racial disparities were noted, with obesity related ASE mortality highest among non-Hispanic American Indians. Regionally, the South exhibited the steepest mortality increase.

Conclusion

Rising trends in obesity-related mortality in abdominal surgical emergencies, showing racial and regional disparities, call for targeted interventions.
背景:肥胖会增加急诊腹部手术患者的死亡风险,但大规模的、人群水平的分析仍然很少。方法:本研究分析了来自CDC WONDER数据库的美国死亡率趋势(1999-2020),使用ICD-10代码评估急性腹部外科急诊(ASE)肥胖患者的总体死亡率和死亡率。计算年龄调整死亡率(AAMRs)和年变化百分比(APCs)。结果:肥胖相关ASE AAMR从2.05 /百万显著上升至5.5 /百万,2018年后显著上升(APC = 23.42)。在肥胖组中,女性死亡率较高,但男性的死亡率增加得更快,这与男性总体上较高的ASE相关死亡率形成了对比。显著的种族差异被注意到,非西班牙裔美国印第安人中肥胖相关的ASE死亡率最高。从区域来看,南方的死亡率增幅最大。结论:腹部外科急诊肥胖相关死亡率呈上升趋势,显示出种族和地区差异,需要有针对性的干预。
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引用次数: 0
Hashtags and healing: Leveraging reddit for holistic ostomy care 标签和治疗:利用reddit进行整体造口护理。
IF 2.7 3区 医学 Q1 SURGERY Pub Date : 2025-11-25 DOI: 10.1016/j.amjsurg.2025.116722
Ava Herzog , Mei Xing G. Zuo , Ritika Patel , Jonathan Canete , Edward Lee
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引用次数: 0
Confronting inequality: The Stark disparity of female representation in surgical oncology journals’ editorial boards 面对不平等:外科肿瘤学期刊编辑委员会中女性代表的明显差异
IF 2.7 3区 医学 Q1 SURGERY Pub Date : 2025-11-25 DOI: 10.1016/j.amjsurg.2025.116749
Brenda Feres , Sofia Wagemaker Viana , Gabriele Eckerdt Lech , Yasmin Biscola Da Cruz , Mecker G. Möller

Background

Inequitable representation on journal editorial boards (EB) may hinder females' career advancement in leadership positions.

Methods

We conducted a cross-sectional study analyzing gender representation in EB of surgical oncology journals. Members were classified as “editor-in-chief”, “senior editorial leadership”, “board and advisory members”, and “editorial management and support”, with first names used to predict female representation.

Results

We included 24 surgical oncology journals and analyzed 2097 names. Females held 33.1 ​% (694/2097) of EB positions (p ​< ​0.001). A chi-square analysis revealed a significant difference in gender representation across editorial roles (p ​< ​0.001). Females held fewer editor-in-chief roles (17.9 ​%, 5/28) compared to board and advisory members (30.1 ​%, 473/1574). Overall, 4/24 journals had a statement about diversity/equity on the EB, despite none showing equal proportion.

Conclusion

Female surgeons remain underrepresented in leadership positions, underscoring the need to improve equity and females’ advancement.
期刊编辑委员会的公平代表权可能会阻碍女性在领导职位上的职业发展。方法采用横断面研究方法,分析外科肿瘤学期刊EB的性别代表性。成员被分为“主编”、“高级编辑领导”、“董事会和顾问成员”以及“编辑管理和支持”,并使用名字来预测女性代表。结果纳入24种外科肿瘤学期刊,分析2097个名称。女性占33.1%(694/2097)的EB职位(p < 0.001)。卡方分析揭示了编辑角色中性别代表性的显著差异(p < 0.001)。与董事会和顾问成员(30.1%,473/1574)相比,女性担任主编的比例(17.9%,5/28)更少。总体而言,4/24的期刊在EB上有关于多样性/公平性的声明,尽管没有一个显示出相同的比例。结论女性外科医生在领导岗位上的比例仍然不足,需要提高性别平等和女性地位。
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引用次数: 0
Healthcare facility volume and evidence-based practice implementation in surgical care of patients with common cancers 医疗机构的数量和循证实践的实施在外科护理的常见癌症患者
IF 2.7 3区 医学 Q1 SURGERY Pub Date : 2025-11-23 DOI: 10.1016/j.amjsurg.2025.116733
Kelsey B. Montgomery , Nicole Rademacher , Joshua S. Richman , Smita Bhatia , Kristy K. Broman

Background

Implementation of evidence-based practices (EBPs) can serve as an indicator of quality for common cancers. This study evaluated the impact of hospital volume on EBP implementation for common cancers.

Methods

This retrospective cohort study of adults who underwent curative-intent treatment for breast, colon, melanoma, and thyroid cancer from 2010 to 2020 used data from the National Cancer Database. Eight EBP measures, two per disease site, were evaluated across facility volume quartiles using mixed-effects logistic regression models adjusted for patient and facility characteristics.

Results

There were 2,893,655 patients (breast n ​= ​1,731,433, colon n ​= ​481,858, melanoma.
n ​= ​418,841, thyroid n ​= ​261,523) (median age 63). EBP implementation was higher at the highest-volume sites compared to lowest (range by measure: 71 ​%–95 ​% and 60 ​%–90 ​% respectively). The adjusted odds of receiving EBP was greater at higher-volume facilities for six of eight measures.

Conclusion

Volume-associations in EBP implementation may influence system-level decision making around care allocation for common cancers.
背景:循证实践(ebp)的实施可以作为普通癌症质量的一个指标。本研究评估了医院容积对常见癌症实施EBP的影响。方法:本回顾性队列研究纳入了2010年至2020年间接受乳腺癌、结肠癌、黑色素瘤和甲状腺癌治疗的成年人,数据来自美国国家癌症数据库。采用混合效应logistic回归模型对患者和设施特征进行调整,评估了八个EBP测量值,每个疾病点两个。结果2893655例(乳腺1731433例,结肠481858例,黑色素瘤);N = 418,841,甲状腺N = 261,523)(中位年龄63)。EBP的实施在容量最大的地方比在容量最小的地方要高(测量范围:分别为71% - 95%和60% - 90%)。在8项措施中的6项中,在容量较大的设施中接受EBP的调整几率更高。结论:EBP实施中的体积关联可能影响系统层面的决策,围绕常见癌症的护理分配。
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引用次数: 0
Mapping pathways to professional support: The role of mentorship, coaching, and sponsorship in surgical careers. 绘制通往专业支持的路径:指导、指导和赞助在外科职业生涯中的作用。
IF 2.7 3区 医学 Q1 SURGERY Pub Date : 2025-11-22 DOI: 10.1016/j.amjsurg.2025.116711
Isabella Faria, Camila R Guetter, Morgan Hopp, Rachna Sridhar, Chantal Reyna, Charlotte Kvasnovsky, Yangyang Ru Yu, Asanthi Ratnasekera, Catherine H Davis

Background: Mentorship, coaching, and sponsorship are critical for professional advancement in surgical careers. This study examines these different forms of support among surgeons and trainees.

Methods: An electronic survey was developed and disseminated on social media and was hosted by the Association of Women Surgeons (AWS). Members and non-members of the AWS from diverse backgrounds, including trainees and students and those in academic and community practices were queried on various demographic and professional characteristics. The primary outcome of interest was access to mentorship, sponsorship and coaching. Chi-square, Fisher's exact tests, and logistic regression models were applied to analyze survey responses.

Results: Of 93 respondents, 48 ​% reported knowing the difference between mentors, coaches, and sponsors. 65 ​% of participants reported having a mentor, 28 ​% a sponsor, and 17 ​% a coach. Community-based surgeons were less likely to have mentors compared to academic surgeons (OR 0.09, 95 ​% CI 0.01-0.69, p ​= ​0.02). Administrative leaders were more likely to have sponsors (admin leaders 44.8 ​% vs. non admin 21.3 ​%, p ​= ​0.02) and coaches (admin leaders 31 ​% vs. non admin 11.5 ​%, p ​= ​0.02). Identifying people within one's organization and time constraints were the most common barriers to having that support.

Conclusions: Efforts by institutions and surgical societies are needed to increase the availability of mentors, sponsors and coaches, particularly for community-based and early-career surgeons.

背景:指导、指导和赞助是外科职业发展的关键。本研究考察了外科医生和实习生之间这些不同形式的支持。方法:由女性外科医生协会(AWS)主办的电子调查在社交媒体上进行了开发和传播。来自不同背景的AWS会员和非会员,包括学员和学生以及从事学术和社区实践的人员,被问及各种人口和专业特征。兴趣的主要结果是获得指导、赞助和指导。采用卡方检验、Fisher精确检验和逻辑回归模型对调查结果进行分析。结果:在93名受访者中,48%的人表示知道导师、教练和赞助商之间的区别。65%的参与者报告有导师,28%的人有赞助商,17%的人有教练。社区外科医生比学术外科医生更不可能有导师(OR 0.09, 95% CI 0.01-0.69, p = 0.02)。行政领导更有可能有赞助者(行政领导44.8%,非行政领导21.3%,p = 0.02)和教练(行政领导31%,非行政领导11.5%,p = 0.02)。确定组织内的人员和时间限制是获得这种支持的最常见障碍。结论:机构和外科学会需要努力增加导师、赞助者和教练的可用性,特别是对社区和早期职业外科医生。
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引用次数: 0
The hidden reason many women are leaving surgery: They're being pushed out. 许多女性放弃手术的隐藏原因是:她们被排挤了。
IF 2.7 3区 医学 Q1 SURGERY Pub Date : 2025-11-22 DOI: 10.1016/j.amjsurg.2025.116739
Cornelia L Griggs, Andrea L Merrill
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引用次数: 0
Assessing the performance of the updated 2021 Field Triage Guidelines with the Need For Trauma Intervention (NFTI) metric 评估更新的2021年现场分诊指南与创伤干预需求(NFTI)指标的绩效。
IF 2.7 3区 医学 Q1 SURGERY Pub Date : 2025-11-21 DOI: 10.1016/j.amjsurg.2025.116729
Tyler J. Johnston , Dina M. Filiberto , Peter B. DePhillips , Chandler E. Morel , Peter E. Fischer , Andy J. Kerwin , Emily K. Lenart , Saskya E. Byerly

Background

Pre-hospital triage is critical for resource-allocation and patient-outcomes. This study aimed to assess the sensitivity (SN) of updated 2021 Field Triage Guidelines (FTGs) and trauma center activation criteria (TAC) related to Need for Trauma Intervention (NFTI).

Methods

Data were collected to identify FTGs Red Criteria (RC) and Yellow Criteria (YC) and NFTI: pRBC within 4 ​h, operating room within 90 ​min, interventional radiology, ICU length-of-stay ≥3 days, mechanical ventilation within 3 days, or death within 60 ​h. SN was analyzed for RC and TAC. Lastly, logistic regressions assessed covariates associated with under-triage (UT).

Results

319 patients were included. SN of RC and TAC were 79 ​% and 77 ​%, respectively. Regression analysis showed UT by RC and TAC was associated with blunt mechanism.

Conclusions

FTGs did not meet ACS goals of ≤5 ​% UT and ≤35 ​% OT with blunt mechanism being associated with UT.
院前分诊对资源分配和患者预后至关重要。本研究旨在评估更新的2021年现场分诊指南(FTGs)和与创伤干预需求(NFTI)相关的创伤中心激活标准(TAC)的敏感性(SN)。方法:收集资料,确定FTGs红色标准(RC)和黄色标准(YC), NFTI: 4 h内pRBC, 90 min内手术室,介入放射学,ICU住院时间≥3天,3天内机械通气,或60 h内死亡。对RC和TAC进行SN分析。最后,逻辑回归评估了与分类不足(UT)相关的协变量。结果:共纳入319例患者。RC和TAC的SN分别为79%和77%。回归分析显示,经RC和TAC处理的UT与钝性机制相关。结论:FTGs未达到ACS的目标,UT≤5%和OT≤35%,钝性机制与UT相关。
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引用次数: 0
期刊
American journal of surgery
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