Background: Navayasa lauha (NL) is a herbometallic preparation (Rasaushadhi) widely used in Ayurveda as a hematinic agent. Nutritional deficiency is a main cause of anemia worldwide. Materials and Methods: NL was trialed on nutritional iron deficiency anemia induced by rice milk diet given for 2 months in albino rats. Iron-deficient rats were then treated with NL for 45 days, and assessment was done on the basis of peripheral blood picture, blood parameters, viz., hemoglobin%, Packed cell volume (PCV), Total red blood cell (TRBC) count, mean cell volume (MCV), mean cell hemoglobin (MCH), MCH concentration serum iron, and “decrease in total iron binding capacity (TIBC).” Results: A highly significant improvement (P < 0.001) in PCV, MCV, MCH, and TRBC and significant increase in Hb% (P < 0.05) and serum iron (P < 0.01), and significant decrease in TIBC (P < 0.01) were also observed. Conclusion: Results of the present study demonstrate that NL could be a promising and safe herbomineral medicine in the treatment of iron deficiency anemia without any gastrointestinal upset, which are generally encountered with modern iron supplements. Significant increase in serum iron and significant decrease in TIBC are indicative of direct effect of trial drug on body iron store in the treatment of anemia.
{"title":"Effect of Navayasa Lauha, an ayurvedic herbomineral formulation on experimentally-induced iron deficiency anemia","authors":"Namrata Joshi, M. Dash, L. Dwivedi, G. Khilnani","doi":"10.4103/asl.asl_5_19","DOIUrl":"https://doi.org/10.4103/asl.asl_5_19","url":null,"abstract":"Background: Navayasa lauha (NL) is a herbometallic preparation (Rasaushadhi) widely used in Ayurveda as a hematinic agent. Nutritional deficiency is a main cause of anemia worldwide. Materials and Methods: NL was trialed on nutritional iron deficiency anemia induced by rice milk diet given for 2 months in albino rats. Iron-deficient rats were then treated with NL for 45 days, and assessment was done on the basis of peripheral blood picture, blood parameters, viz., hemoglobin%, Packed cell volume (PCV), Total red blood cell (TRBC) count, mean cell volume (MCV), mean cell hemoglobin (MCH), MCH concentration serum iron, and “decrease in total iron binding capacity (TIBC).” Results: A highly significant improvement (P < 0.001) in PCV, MCV, MCH, and TRBC and significant increase in Hb% (P < 0.05) and serum iron (P < 0.01), and significant decrease in TIBC (P < 0.01) were also observed. Conclusion: Results of the present study demonstrate that NL could be a promising and safe herbomineral medicine in the treatment of iron deficiency anemia without any gastrointestinal upset, which are generally encountered with modern iron supplements. Significant increase in serum iron and significant decrease in TIBC are indicative of direct effect of trial drug on body iron store in the treatment of anemia.","PeriodicalId":7805,"journal":{"name":"Ancient Science of Life","volume":"37 1","pages":"180 - 187"},"PeriodicalIF":0.0,"publicationDate":"2018-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48722468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
P. Sreeranjini, Anjaly Muraleedharan, H. Krishnarajabhatt
Pregnancy parturition and puerperium are the most important events taking place in a woman's life. Even though as we all aware of the importance of postnatal care, it is the most ignored in present era due to busy life schedule. As mentioned in our classics the śūnya śarīratva (Empty bodied) of sūtikā (Puerperal women) due to labour pains, rakta parisravaṇa (Bleeding) and dhātu śithilatā (Unsteadiness of dhātus) causes vāta kopa which may lead to diseases that become incurable or curable with difficulty. Proper adherence to postnatal care explained by āyurveda classics will results in faster restoration of mother's health by attaining replenishment of dhāthus, steadiness of body, and proper reproductive cycle. Along with the dietetic regulations and external therapies practicing some of the yoga procedures based on physical strength with restricted time, duration, and in a proper manner will provide an additional support in strengthening the abdominal, pelvic fascia and muscles, reducing the abdominal and pelvic girth, preventing excessive weight gain by reducing the fat deposition, and also helps in maintaining emotional stability. The study was conducted in 12 patients, 6 were included in normal vaginal delivery group and 6 included in caesarean section group. Along with sūtikāparicaryā specific yoga exercises were also advised. Remarkable outcome was noticed in reducing the weight and abdominal girth.
{"title":"Combined effect of yoga and sūtikāparicaryā in normal vaginal delivery and caesarean section: Case series","authors":"P. Sreeranjini, Anjaly Muraleedharan, H. Krishnarajabhatt","doi":"10.4103/asl.asl_15_18","DOIUrl":"https://doi.org/10.4103/asl.asl_15_18","url":null,"abstract":"Pregnancy parturition and puerperium are the most important events taking place in a woman's life. Even though as we all aware of the importance of postnatal care, it is the most ignored in present era due to busy life schedule. As mentioned in our classics the śūnya śarīratva (Empty bodied) of sūtikā (Puerperal women) due to labour pains, rakta parisravaṇa (Bleeding) and dhātu śithilatā (Unsteadiness of dhātus) causes vāta kopa which may lead to diseases that become incurable or curable with difficulty. Proper adherence to postnatal care explained by āyurveda classics will results in faster restoration of mother's health by attaining replenishment of dhāthus, steadiness of body, and proper reproductive cycle. Along with the dietetic regulations and external therapies practicing some of the yoga procedures based on physical strength with restricted time, duration, and in a proper manner will provide an additional support in strengthening the abdominal, pelvic fascia and muscles, reducing the abdominal and pelvic girth, preventing excessive weight gain by reducing the fat deposition, and also helps in maintaining emotional stability. The study was conducted in 12 patients, 6 were included in normal vaginal delivery group and 6 included in caesarean section group. Along with sūtikāparicaryā specific yoga exercises were also advised. Remarkable outcome was noticed in reducing the weight and abdominal girth.","PeriodicalId":7805,"journal":{"name":"Ancient Science of Life","volume":"37 1","pages":"217 - 221"},"PeriodicalIF":0.0,"publicationDate":"2018-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48082223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Dey, Satyajyoti Kanjilal, R. Biswas, A. Adhikari, Satyabrata Mohapatra, D. Gandhi, B. Bhatt, Shiladitya Choudhuri, P. Chakraborty, T. Sur, A. Narwaria, C. Katiyar
Background: Ayurvedic Ariṣṭa preparations hold an age-old heritage in the prevention and cure of metabolic disorders and associated complications. Aim: The aim of the study was to study the antidiabetic activity of a self-fermented Ariṣṭa preparation (DB-07) and its potential in preventing or curing diabetes-induced nephropathy in experimental models. Materials and Methods: Rats with Streptozotocin-induced diabetes were used for studying the various dose effects of DB-07 (2.5, 3, and 3.5 ml/kg/day) in preventive and therapeutic treatment schedules. Metformin (500 mg/kg) was used as a standard drug. Fasting blood glucose and biochemical parameters such as blood protein, urea, uric acid, and creatinine were accessed by various biochemical tests. In vitro α-amylase and α-glucosidase inhibition assay and 2-deoxy glucose uptake assay using rat L6 myotubes were studied for determining the antidiabetic mechanism of action. Results: A dose-dependent and statistically significant effect on lowering the fasting blood glucose level was observed in both preventive and therapeutic scheduled treatments. Treatment with DB-07 significantly reversed the altered biochemical parameters and the effects were comparable to metformin-treated rats. DB-07 exhibited concentration-dependent inhibition of both α-amylase and α-glucosidase enzymes with an IC50 values of 10.93 μg/ml and 8.73 μg/ml, respectively. DB-07 also showed glucose uptake potential (ca. 70% activity at 125 μg/ml) in differentiated L6 myotubes. Conclusions: These observations have revealed the antidiabetic and nephroprotective potential of DB-07. DB-07 can be a potential herbal alternative to maintain a healthy blood glucose level and will prove useful in diabetes-associated renal complications.
{"title":"Antidiabetic and nephroprotective potential of polyherbal self-fermented Ariṣṭa formulation: Evidence-based research","authors":"A. Dey, Satyajyoti Kanjilal, R. Biswas, A. Adhikari, Satyabrata Mohapatra, D. Gandhi, B. Bhatt, Shiladitya Choudhuri, P. Chakraborty, T. Sur, A. Narwaria, C. Katiyar","doi":"10.4103/asl.ASL_61_19","DOIUrl":"https://doi.org/10.4103/asl.ASL_61_19","url":null,"abstract":"Background: Ayurvedic Ariṣṭa preparations hold an age-old heritage in the prevention and cure of metabolic disorders and associated complications. Aim: The aim of the study was to study the antidiabetic activity of a self-fermented Ariṣṭa preparation (DB-07) and its potential in preventing or curing diabetes-induced nephropathy in experimental models. Materials and Methods: Rats with Streptozotocin-induced diabetes were used for studying the various dose effects of DB-07 (2.5, 3, and 3.5 ml/kg/day) in preventive and therapeutic treatment schedules. Metformin (500 mg/kg) was used as a standard drug. Fasting blood glucose and biochemical parameters such as blood protein, urea, uric acid, and creatinine were accessed by various biochemical tests. In vitro α-amylase and α-glucosidase inhibition assay and 2-deoxy glucose uptake assay using rat L6 myotubes were studied for determining the antidiabetic mechanism of action. Results: A dose-dependent and statistically significant effect on lowering the fasting blood glucose level was observed in both preventive and therapeutic scheduled treatments. Treatment with DB-07 significantly reversed the altered biochemical parameters and the effects were comparable to metformin-treated rats. DB-07 exhibited concentration-dependent inhibition of both α-amylase and α-glucosidase enzymes with an IC50 values of 10.93 μg/ml and 8.73 μg/ml, respectively. DB-07 also showed glucose uptake potential (ca. 70% activity at 125 μg/ml) in differentiated L6 myotubes. Conclusions: These observations have revealed the antidiabetic and nephroprotective potential of DB-07. DB-07 can be a potential herbal alternative to maintain a healthy blood glucose level and will prove useful in diabetes-associated renal complications.","PeriodicalId":7805,"journal":{"name":"Ancient Science of Life","volume":"37 1","pages":"188 - 199"},"PeriodicalIF":0.0,"publicationDate":"2018-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42417099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Divya Korampatta, Prakash Mangalasseri, Anitha K Viswambharan
Background: Polycystic ovary syndrome (PCOS) is a multisystem disorder having a great impact on psychological and social functioning resulting in reduced Quality of life (QOL). Methodology: Women diagnosed with PCOS as per the Rotterdam criteria, in the age group of 18-40 without any history of psychiatric illness and recent stressful life events or trauma attending the OPD of Prasuti tantra evam Striroga of a tertiary care Ayurveda hospital were recruited for the study. A cross sectional study in 50 eligible women was carried out with World Health Organization Quality of Life questionnaire (WHOQOL-BREF), Symptom Checklist 90 R (SCL-90 R) to assess QOL and psychiatric morbidity respectively. As an important measure of QOL, sexual satisfaction was also measured with Visual Analogue Scale (VAS). Results: QOL was less than the mean value in 74% in the psychological domain and 68% in social domain and 62% each in physical and environmental domain indicating poorer QOL. On detailed psychological screening, mean scores of depression, obsessive- compulsive and anxiety domains were higher. Sexual satisfaction was moderate to high in married participants. Conclusion: Psychiatric morbidities are highly prevalent in PCOS women and they have reduced QOL. These psychiatric morbidities should be addressed for better outcome in PCOS management.
{"title":"A cross sectional survey on quality of life and psychiatric morbidity in women with polycystic ovary syndrome","authors":"Divya Korampatta, Prakash Mangalasseri, Anitha K Viswambharan","doi":"10.4103/asl.asl_6_18","DOIUrl":"https://doi.org/10.4103/asl.asl_6_18","url":null,"abstract":"Background: Polycystic ovary syndrome (PCOS) is a multisystem disorder having a great impact on psychological and social functioning resulting in reduced Quality of life (QOL). Methodology: Women diagnosed with PCOS as per the Rotterdam criteria, in the age group of 18-40 without any history of psychiatric illness and recent stressful life events or trauma attending the OPD of Prasuti tantra evam Striroga of a tertiary care Ayurveda hospital were recruited for the study. A cross sectional study in 50 eligible women was carried out with World Health Organization Quality of Life questionnaire (WHOQOL-BREF), Symptom Checklist 90 R (SCL-90 R) to assess QOL and psychiatric morbidity respectively. As an important measure of QOL, sexual satisfaction was also measured with Visual Analogue Scale (VAS). Results: QOL was less than the mean value in 74% in the psychological domain and 68% in social domain and 62% each in physical and environmental domain indicating poorer QOL. On detailed psychological screening, mean scores of depression, obsessive- compulsive and anxiety domains were higher. Sexual satisfaction was moderate to high in married participants. Conclusion: Psychiatric morbidities are highly prevalent in PCOS women and they have reduced QOL. These psychiatric morbidities should be addressed for better outcome in PCOS management.","PeriodicalId":7805,"journal":{"name":"Ancient Science of Life","volume":"37 1","pages":"208 - 213"},"PeriodicalIF":0.0,"publicationDate":"2018-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48532753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Shailaja Rajathurai, Parthasarathy Kannabiran, S. Parameswaran
Two cases of ocular injury due to accidental exposure to latex and vapors of Euphorbia umbellata are described in this report. With the direct exposure of eyes to split drops of latex and inhalation exposure to vapors resulted in severe conjunctival congestion with bilateral peri-orbital edema without pain and inflammatory features with intense burning sensation of both the eyes, photophobia, blurred vision, severe redness with blepharospasm, intense thirst, nausea, and projectile vomiting. The symptoms reduced markedly after vomiting induced by the consumption of Nilavembu Kudineer, a Siddha poly herbal decoction. Redness of eyes relieved immediately with the instillation of mother's milk. It is construed that the presence of phorbol esters, a type of diterpenes in the latex of Euphorbia umbellata could have produced inflammatory responses by virtue of histamine, cytokine, and protease release which induced vomiting, pain, heat, and redness. This case report emphasizes the importance of using personal protective equipment such as goggles, gloves, and face mask while collecting and preparing medicines using the aerial parts of Euphorbia umbellata.
{"title":"Ocular toxicity in human subjects through accidental exposure to latex of Euphorbia umbellata (Pax) bruyns","authors":"Shailaja Rajathurai, Parthasarathy Kannabiran, S. Parameswaran","doi":"10.4103/asl.asl_77_19","DOIUrl":"https://doi.org/10.4103/asl.asl_77_19","url":null,"abstract":"Two cases of ocular injury due to accidental exposure to latex and vapors of Euphorbia umbellata are described in this report. With the direct exposure of eyes to split drops of latex and inhalation exposure to vapors resulted in severe conjunctival congestion with bilateral peri-orbital edema without pain and inflammatory features with intense burning sensation of both the eyes, photophobia, blurred vision, severe redness with blepharospasm, intense thirst, nausea, and projectile vomiting. The symptoms reduced markedly after vomiting induced by the consumption of Nilavembu Kudineer, a Siddha poly herbal decoction. Redness of eyes relieved immediately with the instillation of mother's milk. It is construed that the presence of phorbol esters, a type of diterpenes in the latex of Euphorbia umbellata could have produced inflammatory responses by virtue of histamine, cytokine, and protease release which induced vomiting, pain, heat, and redness. This case report emphasizes the importance of using personal protective equipment such as goggles, gloves, and face mask while collecting and preparing medicines using the aerial parts of Euphorbia umbellata.","PeriodicalId":7805,"journal":{"name":"Ancient Science of Life","volume":"37 1","pages":"222 - 225"},"PeriodicalIF":0.0,"publicationDate":"2018-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46155693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Chronic wounds affect around 2.4 – 4.5 million patients in the United States. The burden of wound management is growing rapidly. Objective: Management of chronic wounds with integrated conventional medicine and Ayurveda treatment. Clinical Features: A 52-year-old female patient, presented with non-healing chronic wound on the right leg with pain persisting for 5 years. Initial measurement of the wound was 48 cm length × 13 cm width × 0.4 cm depth. Intervention and Outcomes: Wound depth was measured during different stages of healing along with photographic images. Patient was given Ciprofloxacin 500mg twice daily for 10 days, compression leg wraps and diuretics along with washing of the wound with Triphala decoction daily and application of wound dressing with Turmeric powder, neem bark powder and Medihoney daily were done. Marma therapy was performed once a week. Patient was also suggested kapha pacifying diet and lifestyle. Results: The wound was completely healed with normal skin coloration by the sixth week. Conclusions: This case study discusses the use of integration of ayurvedic herbs with conventional medicine for the management of wound healing. Interventional studies should be conducted to better understand the effectiveness of this integrative approach for the treatment of chronic wounds.
{"title":"Integration of ayurveda and conventional medicine for chronic wound healing","authors":"Anupama Kizhakkeveettil, Christie Smirl, Jayagopal Parla","doi":"10.4103/asl.ASL_108_18","DOIUrl":"https://doi.org/10.4103/asl.ASL_108_18","url":null,"abstract":"Background: Chronic wounds affect around 2.4 – 4.5 million patients in the United States. The burden of wound management is growing rapidly. Objective: Management of chronic wounds with integrated conventional medicine and Ayurveda treatment. Clinical Features: A 52-year-old female patient, presented with non-healing chronic wound on the right leg with pain persisting for 5 years. Initial measurement of the wound was 48 cm length × 13 cm width × 0.4 cm depth. Intervention and Outcomes: Wound depth was measured during different stages of healing along with photographic images. Patient was given Ciprofloxacin 500mg twice daily for 10 days, compression leg wraps and diuretics along with washing of the wound with Triphala decoction daily and application of wound dressing with Turmeric powder, neem bark powder and Medihoney daily were done. Marma therapy was performed once a week. Patient was also suggested kapha pacifying diet and lifestyle. Results: The wound was completely healed with normal skin coloration by the sixth week. Conclusions: This case study discusses the use of integration of ayurvedic herbs with conventional medicine for the management of wound healing. Interventional studies should be conducted to better understand the effectiveness of this integrative approach for the treatment of chronic wounds.","PeriodicalId":7805,"journal":{"name":"Ancient Science of Life","volume":"37 1","pages":"168 - 172"},"PeriodicalIF":0.0,"publicationDate":"2018-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48165291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Context: With a rising need for development of drugs that are effective with multifaceted therapeutics for the treatment of depression and the associated behavioral changes, brāhmī ghr̥ta offers a choice of treatment. The challenge of palatability of ghr̥ta in therapeutic dose of 20 to 40 g per day can be overcome by potentiation and the same was tested in the present study. Aims: To evaluate and compare the efficacy of 1x Brāhmī Ghr̥ta (BG) and 10x BG in Chronic unpredictable mild stress (CUMS) induced behavioral alterations. Settings and Design: Randomized Controlled preclinical trial. Materials and Methods: Self prepared and standardized 1x Brāhmī ghr̥ta (3.6 g/kg) and 10x BG (3.6, 1.8 and 0.9 g/kg) were evaluated in CUMS induced behavioral changes in rats by using sucrose preference (SPT), forced swim (FST), and memory assessment with elevated plus maze (EPM) tests. Statistical Analysis Used: One-way ANOVA followed by Post hoc analysis. Results: 28 days CUMS procedure induced depression in rats which was confirmed. Upon comparison with CUMS control group, 1x BG and 10x BG, at all three dose levels, increased the sucrose preference (P < 0.05); in forced swim test increased the number of rotations (P < 0.001) and in elevated plus maze test significantly lowered the transfer latency time in retention transfer latency [1X BG (P < 0.05) and10X BG (P < 0.001)]. Further, 10x BG at all 3 dose levels showed significantly better results in comparison to 1x BG in FST (P < 0.01) and EPM (P < 0.05). Conclusions: Both the samples of brāhmī ghr̥ta āēapākī (1x) and daśapākī (10x), showed antidepressant effect and reversal of memory impairment induced by CUMS model. This is the first study to report that drug potentiation increases the efficacy and achieves dose reduction.
{"title":"Comparative Efficacy of Ekapākī (1x) and Daśapākī (10x) Brāhmī Ghr̥ta in Chronic Unpredictable Mild Stress Induced Behavioral Alterations in Rats","authors":"S. Gadgil, A. Wele, Vidushi Sharma, M. Pawar","doi":"10.4103/asl.ASL_141_18","DOIUrl":"https://doi.org/10.4103/asl.ASL_141_18","url":null,"abstract":"Context: With a rising need for development of drugs that are effective with multifaceted therapeutics for the treatment of depression and the associated behavioral changes, brāhmī ghr̥ta offers a choice of treatment. The challenge of palatability of ghr̥ta in therapeutic dose of 20 to 40 g per day can be overcome by potentiation and the same was tested in the present study. Aims: To evaluate and compare the efficacy of 1x Brāhmī Ghr̥ta (BG) and 10x BG in Chronic unpredictable mild stress (CUMS) induced behavioral alterations. Settings and Design: Randomized Controlled preclinical trial. Materials and Methods: Self prepared and standardized 1x Brāhmī ghr̥ta (3.6 g/kg) and 10x BG (3.6, 1.8 and 0.9 g/kg) were evaluated in CUMS induced behavioral changes in rats by using sucrose preference (SPT), forced swim (FST), and memory assessment with elevated plus maze (EPM) tests. Statistical Analysis Used: One-way ANOVA followed by Post hoc analysis. Results: 28 days CUMS procedure induced depression in rats which was confirmed. Upon comparison with CUMS control group, 1x BG and 10x BG, at all three dose levels, increased the sucrose preference (P < 0.05); in forced swim test increased the number of rotations (P < 0.001) and in elevated plus maze test significantly lowered the transfer latency time in retention transfer latency [1X BG (P < 0.05) and10X BG (P < 0.001)]. Further, 10x BG at all 3 dose levels showed significantly better results in comparison to 1x BG in FST (P < 0.01) and EPM (P < 0.05). Conclusions: Both the samples of brāhmī ghr̥ta āēapākī (1x) and daśapākī (10x), showed antidepressant effect and reversal of memory impairment induced by CUMS model. This is the first study to report that drug potentiation increases the efficacy and achieves dose reduction.","PeriodicalId":7805,"journal":{"name":"Ancient Science of Life","volume":"37 1","pages":"141 - 147"},"PeriodicalIF":0.0,"publicationDate":"2018-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45092606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Meenakshi Gusain, A. Srivastava, G. Shukla, Kshiteeja Choudhary
Overweight and obesity have become major health problems that can lead to or aggravate other medical problems such as Hypertension and Diabetes Mellitus. Hypothyroidism is defined as failure of the thyroid gland to produce sufficient thyroid hormone to meet the metabolic demands of the body. A female patient aged 36 years and was a housewife reported to the Panchakarma O.P.D. of Rishikul campus, Haridwar with complaints of increase in weight, heaviness in the body, pain and stiffness in joints and sore throat with known case of hypothyroidism and was on medication of thyroxine 25μg OD for 2 months. She had earlier taken hormonal therapy (progesterone) for infertility. The patient had undergone Virecana Karma (medicated purgative therapy), in which dīpana–pācana (increasing digestive fire for digesting undigested material) with Pañcakola Phāṇṭa, snehapāna (internal oleation) with goghṛta (cow's butter fat), virecana (medicated purgative therapy) with Trivṛt Leham, Kuṭakī, Āragvadha, jaggery and Icchābhedī Rasa followed by anupāna ( drink taken with or after medicine) of Drākṣā was given. After saṃsarjana krama ( a diet regimen after Pañcakarma for improving digestion and regaining strength of patient), Ārogyavardhinī Vaṭi was introduced for 7 weeks in a dose of 2 tablets twice in a day (Each tab 250 mg) with lukewarm water. There was marked relief in the symptoms of heaviness, pain, stiffness, weight reduction from 76 kg to 72 kg with significant improvement in TSH level from 7.98 μg/dl to 2.07 μg/dl after completion of saṃsarjana krama (a diet regimen after Pañcakarma for improving digestion and regaining strength of patient). 18 days after it, TSH level become 3.83 μg/dl and weight reduced to 70 kg. Again after seven weeks TSH was 2.99 μg/dl and weight was 67 kg. Six weeks after discontinuation of Ārogyavardhinī Vaṭi TSH was 2.32 μg/dl and weight was 67 kg. Virecana (medicated purgative therapy) is effective in management of obesity and Thyroid level.
{"title":"Efficacy of virechana karma in the management of obesity and hypothyroidism: A case study","authors":"Meenakshi Gusain, A. Srivastava, G. Shukla, Kshiteeja Choudhary","doi":"10.4103/asl.ASL_127_17","DOIUrl":"https://doi.org/10.4103/asl.ASL_127_17","url":null,"abstract":"Overweight and obesity have become major health problems that can lead to or aggravate other medical problems such as Hypertension and Diabetes Mellitus. Hypothyroidism is defined as failure of the thyroid gland to produce sufficient thyroid hormone to meet the metabolic demands of the body. A female patient aged 36 years and was a housewife reported to the Panchakarma O.P.D. of Rishikul campus, Haridwar with complaints of increase in weight, heaviness in the body, pain and stiffness in joints and sore throat with known case of hypothyroidism and was on medication of thyroxine 25μg OD for 2 months. She had earlier taken hormonal therapy (progesterone) for infertility. The patient had undergone Virecana Karma (medicated purgative therapy), in which dīpana–pācana (increasing digestive fire for digesting undigested material) with Pañcakola Phāṇṭa, snehapāna (internal oleation) with goghṛta (cow's butter fat), virecana (medicated purgative therapy) with Trivṛt Leham, Kuṭakī, Āragvadha, jaggery and Icchābhedī Rasa followed by anupāna ( drink taken with or after medicine) of Drākṣā was given. After saṃsarjana krama ( a diet regimen after Pañcakarma for improving digestion and regaining strength of patient), Ārogyavardhinī Vaṭi was introduced for 7 weeks in a dose of 2 tablets twice in a day (Each tab 250 mg) with lukewarm water. There was marked relief in the symptoms of heaviness, pain, stiffness, weight reduction from 76 kg to 72 kg with significant improvement in TSH level from 7.98 μg/dl to 2.07 μg/dl after completion of saṃsarjana krama (a diet regimen after Pañcakarma for improving digestion and regaining strength of patient). 18 days after it, TSH level become 3.83 μg/dl and weight reduced to 70 kg. Again after seven weeks TSH was 2.99 μg/dl and weight was 67 kg. Six weeks after discontinuation of Ārogyavardhinī Vaṭi TSH was 2.32 μg/dl and weight was 67 kg. Virecana (medicated purgative therapy) is effective in management of obesity and Thyroid level.","PeriodicalId":7805,"journal":{"name":"Ancient Science of Life","volume":"37 1","pages":"158 - 161"},"PeriodicalIF":0.0,"publicationDate":"2018-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43172255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Backround: Haemorrhoids are the most common problems of the anal canal due to hereditary, anatomical deformities, exciting causes, diet etc. In Ayurveda, disease arśas which is explained by all the classics can be correlated to haemorrhoids. In modern surgery, different surgical methods are advocated to overcome the haemorrhoids. However, modern management has its own limitations and in that it causes various side effects, recurrence, severe pain etc., Ācārya Suśruta advocates different treatment modalities such as auṣadha (medical), śastra (surgical), kṣāra (alkali cauterization) and agni karma (heat cauterization) in the management of arśas. Aims and Objectives: Considering this, the present study has been undertaken to evaluate the comparative efficacy of Apāmārga Kṣāra Sūtra and Apāmārga Kṣāra Taila in the management of arśas. Materials and Methods: A total of 60 patients enrolled for the study, out of which 30 patients were randomly assigned into first group (control group) and were subjected to Apāmārga Kṣāra Sūtra (AKS). 30 patients were randomly assigned into the second group. In second group, i. e trial group, to obtain efficacious and safe results an innovative method was planned by using Apāmārga Kṣāra Taila basti (AKT). AKT involved administration of oil through anal route. Results: After intervention, it was observed that both AKS and AKT group are found to be equally effective to treat the arśas with reduction in clinical parameters such as bleeding per rectum, pain in ano, protrusion of mass and in constipation. In both the groups, results obtained with the above parameters showed statistically highly significant result with P value < 0.001. Conclusion: Hence, Apāmārga Kṣāra Sūtra and Apāmārga Kṣāra Taila are found to be affective in the management of arśas.
{"title":"Āyurvedic management of Arśas with Apāmārga Kṣāra Taila: A randomized controlled clinical study","authors":"S. Laxmikant, S. Kumari, M. Rajagopal","doi":"10.4103/asl.ASL_102_17","DOIUrl":"https://doi.org/10.4103/asl.ASL_102_17","url":null,"abstract":"Backround: Haemorrhoids are the most common problems of the anal canal due to hereditary, anatomical deformities, exciting causes, diet etc. In Ayurveda, disease arśas which is explained by all the classics can be correlated to haemorrhoids. In modern surgery, different surgical methods are advocated to overcome the haemorrhoids. However, modern management has its own limitations and in that it causes various side effects, recurrence, severe pain etc., Ācārya Suśruta advocates different treatment modalities such as auṣadha (medical), śastra (surgical), kṣāra (alkali cauterization) and agni karma (heat cauterization) in the management of arśas. Aims and Objectives: Considering this, the present study has been undertaken to evaluate the comparative efficacy of Apāmārga Kṣāra Sūtra and Apāmārga Kṣāra Taila in the management of arśas. Materials and Methods: A total of 60 patients enrolled for the study, out of which 30 patients were randomly assigned into first group (control group) and were subjected to Apāmārga Kṣāra Sūtra (AKS). 30 patients were randomly assigned into the second group. In second group, i. e trial group, to obtain efficacious and safe results an innovative method was planned by using Apāmārga Kṣāra Taila basti (AKT). AKT involved administration of oil through anal route. Results: After intervention, it was observed that both AKS and AKT group are found to be equally effective to treat the arśas with reduction in clinical parameters such as bleeding per rectum, pain in ano, protrusion of mass and in constipation. In both the groups, results obtained with the above parameters showed statistically highly significant result with P value < 0.001. Conclusion: Hence, Apāmārga Kṣāra Sūtra and Apāmārga Kṣāra Taila are found to be affective in the management of arśas.","PeriodicalId":7805,"journal":{"name":"Ancient Science of Life","volume":"37 1","pages":"153 - 157"},"PeriodicalIF":0.0,"publicationDate":"2018-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48603645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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