Background: Telosma pallida (L.) Kurz., is one of the traditional medicinal plants from Asclepiadaceae family. It is abundantly available in Gujarat, India during monsoon. It is a slender and deciduous climber used traditionally in the treatment of various diseases such as cough, cold, skin diseases etc., Aims: To study the leaves of Telosma pallida (L.) Kurz. for detailed Pharmacognostic characters and Analytical Profile. Materials and Methods: In this work pharmacognostic, preliminary phytochemical screening, fluorescence analysis, and HPTLC profile of leaves were determined following standard procedures. Results: The leaves are simple, entire, opposite, cordate in shape, the upper surface is dark green and lower surface is light green in colour. The Transverse section of a leaf through petiole shows the presence of uniseriate multicellular warty trichomes and laticifer cells at the adjacent side of the phloem. Surface study shows paracytic and anomocytic type of stomata. Preliminary physicochemical analysis shows water soluble extractive value as 28.44 ± 2.89% w/w and alcohol soluble extractive value as 14.60 ± 0.79% w/w. Preliminary phytochemical analysis of extracts shows the presence of glycosides, alkaloids, carbohydrates, proteins, amino acids and flavonoids. Conclusion: The information obtained from this research work may be useful to establish the botanical as well as analytical standards for the leaves of T. pallida.
{"title":"Detailed pharmacognostical and analytical profile of telosma pallida (l.) kurz. (leaf): A folklore medicinal plant of Gujarat State","authors":"R. Kanakhara, H. Rudrappa, V. Shukla, R. Acharya","doi":"10.4103/asl.ASL_97_17","DOIUrl":"https://doi.org/10.4103/asl.ASL_97_17","url":null,"abstract":"Background: Telosma pallida (L.) Kurz., is one of the traditional medicinal plants from Asclepiadaceae family. It is abundantly available in Gujarat, India during monsoon. It is a slender and deciduous climber used traditionally in the treatment of various diseases such as cough, cold, skin diseases etc., Aims: To study the leaves of Telosma pallida (L.) Kurz. for detailed Pharmacognostic characters and Analytical Profile. Materials and Methods: In this work pharmacognostic, preliminary phytochemical screening, fluorescence analysis, and HPTLC profile of leaves were determined following standard procedures. Results: The leaves are simple, entire, opposite, cordate in shape, the upper surface is dark green and lower surface is light green in colour. The Transverse section of a leaf through petiole shows the presence of uniseriate multicellular warty trichomes and laticifer cells at the adjacent side of the phloem. Surface study shows paracytic and anomocytic type of stomata. Preliminary physicochemical analysis shows water soluble extractive value as 28.44 ± 2.89% w/w and alcohol soluble extractive value as 14.60 ± 0.79% w/w. Preliminary phytochemical analysis of extracts shows the presence of glycosides, alkaloids, carbohydrates, proteins, amino acids and flavonoids. Conclusion: The information obtained from this research work may be useful to establish the botanical as well as analytical standards for the leaves of T. pallida.","PeriodicalId":7805,"journal":{"name":"Ancient Science of Life","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47173280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Preclinical and clinical studies have shown the importance of calorie restriction diet in cardiovascular risk factors such as weight. In this study, our objective is to compare the Naturopathic short-term fasting therapy with low-calorie diet on anthropometric and leptin measures among obese and overweight persons. Materials and Methods: Obese and overweight subjects (n = 84, 59.52% females) with Body Mass Index (BMI) ≥25 were randomized into fasting therapy intervention (n = 42) and a low-calorie diet intervention (n = 42). After a written informed consent, the fasting therapy and low-calorie diet intervention group underwent a very low-calorie diet (288-904 kcal) and a low-calorie diet (1234 kcal) respectively for 10 days. Subjects in both the groups were assessed with serum leptin levels and anthropometric parameters such as BMI, weight, waist circumference (WC), hip circumference (HC) and waist-hip ratio (WHR) at the baseline and after 10 days. Results: Within-group comparison showed both the groups did better in all the parameters. However, greater changes were observed in the fasting group as compared to the low-calorie diet group. Changes in BMI, weight, HC and WC were significantly different in the two groups (P < 0.05), except for serum leptin (P > 0.05). Conclusions: The findings support that, both short-term fasting therapy and a low–calorie diet are beneficial in reducing leptin and anthropometric parameters among obese or overweight subjects. However, long-term adherence of weight loss with these interventions need to be tested with future studies.
{"title":"Comparing the effects of short-term fasting therapy and low-calorie diet on anthropometric and leptin measures among obese or overweight persons: Randomized controlled trial","authors":"P. Shetty, S. Dinesh, N. Halappa, T. Rajany","doi":"10.4103/asl.ASL_1_18","DOIUrl":"https://doi.org/10.4103/asl.ASL_1_18","url":null,"abstract":"Background: Preclinical and clinical studies have shown the importance of calorie restriction diet in cardiovascular risk factors such as weight. In this study, our objective is to compare the Naturopathic short-term fasting therapy with low-calorie diet on anthropometric and leptin measures among obese and overweight persons. Materials and Methods: Obese and overweight subjects (n = 84, 59.52% females) with Body Mass Index (BMI) ≥25 were randomized into fasting therapy intervention (n = 42) and a low-calorie diet intervention (n = 42). After a written informed consent, the fasting therapy and low-calorie diet intervention group underwent a very low-calorie diet (288-904 kcal) and a low-calorie diet (1234 kcal) respectively for 10 days. Subjects in both the groups were assessed with serum leptin levels and anthropometric parameters such as BMI, weight, waist circumference (WC), hip circumference (HC) and waist-hip ratio (WHR) at the baseline and after 10 days. Results: Within-group comparison showed both the groups did better in all the parameters. However, greater changes were observed in the fasting group as compared to the low-calorie diet group. Changes in BMI, weight, HC and WC were significantly different in the two groups (P < 0.05), except for serum leptin (P > 0.05). Conclusions: The findings support that, both short-term fasting therapy and a low–calorie diet are beneficial in reducing leptin and anthropometric parameters among obese or overweight subjects. However, long-term adherence of weight loss with these interventions need to be tested with future studies.","PeriodicalId":7805,"journal":{"name":"Ancient Science of Life","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43719321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Ali, Hamiduddin, Mohammad Zaigham, M. Ikram, Mohd Shadab, G. Rather
Introduction: Zahar Mohra (Serpentine/Bezoar stone) is mentioned as efficacious and a useful drug indicated in heart diseases in Unani medicine. It is also used to remove effect of poison and is termed in Unani Medicine as Daf-e-Zahar or Fad-e-Zahar (antidote). It acts as preservative of quwa (faculty) and ruh (pneuma). Unani physicians commonly use Zahar Mohra (ZM) in Kushta (Calcined) form, because the Kushta gives quick and potent response. In this work owing to its beneficial and efficacious use, Kushta-e-Zahar Mohra (KZM) was prepared as per contemporary methods and was subjected to preliminary physicochemical analysis to develop a standard. Materials and Methods: KZM was prepared as per contemporary method (Muffle furnace) by simulation of the heat pattern as per classical texts/method and its physico-chemical and instrumental analysis including XRD, ICP-MS and AAS was performed. Statistical analysis used was Mean ± SEM. Results: Prepared Kushta passes the classical Unani specification tests, contemporary test data for various physicochemical parameters were also set in. XRD analysis indicated presence of Mg2Si O4 (Magnesium Silicate) and Ca (Cl O)2. 3H2O (Calcium Chlorite Hydrate) phase. Conclusions: The study indicates content and physicochemical standards of KZM prepared by contemporary method; it can be a better choice. KZM can be safe for use as acclaimed for heart diseases in Unani System of Medicine.
{"title":"Preliminary physicochemical evaluation of Kushta-e-Aahar Mohra: A unique formulation of Unani medicine","authors":"M. Ali, Hamiduddin, Mohammad Zaigham, M. Ikram, Mohd Shadab, G. Rather","doi":"10.4103/asl.ASL_145_17","DOIUrl":"https://doi.org/10.4103/asl.ASL_145_17","url":null,"abstract":"Introduction: Zahar Mohra (Serpentine/Bezoar stone) is mentioned as efficacious and a useful drug indicated in heart diseases in Unani medicine. It is also used to remove effect of poison and is termed in Unani Medicine as Daf-e-Zahar or Fad-e-Zahar (antidote). It acts as preservative of quwa (faculty) and ruh (pneuma). Unani physicians commonly use Zahar Mohra (ZM) in Kushta (Calcined) form, because the Kushta gives quick and potent response. In this work owing to its beneficial and efficacious use, Kushta-e-Zahar Mohra (KZM) was prepared as per contemporary methods and was subjected to preliminary physicochemical analysis to develop a standard. Materials and Methods: KZM was prepared as per contemporary method (Muffle furnace) by simulation of the heat pattern as per classical texts/method and its physico-chemical and instrumental analysis including XRD, ICP-MS and AAS was performed. Statistical analysis used was Mean ± SEM. Results: Prepared Kushta passes the classical Unani specification tests, contemporary test data for various physicochemical parameters were also set in. XRD analysis indicated presence of Mg2Si O4 (Magnesium Silicate) and Ca (Cl O)2. 3H2O (Calcium Chlorite Hydrate) phase. Conclusions: The study indicates content and physicochemical standards of KZM prepared by contemporary method; it can be a better choice. KZM can be safe for use as acclaimed for heart diseases in Unani System of Medicine.","PeriodicalId":7805,"journal":{"name":"Ancient Science of Life","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45202628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Amit Nakanekar, Pallavi Thote, Niharika Palan, Prashant Deshmukh, J. Gulhane, Amrut S. Salunke
Background: Acute renal calculus is a common recurrent and emergency condition with an annual incidence of one to two cases per 1000. Lifetime risk of its recurrence is 10–20% in men and 3–5% in women. It is an important cause of acute renal failure. About 12% of the population of India is reported to have urinary stones. Acute attacks are managed by analgesics, antispasmodics and use of Non-steroidal anti-inflammatory drugs (NSAIDs). In this case report we report an acute renal colic case managed by Ayurveda treatment without using any modern analgesics. Case Summary: A 34 year old male patient presented with severe pain in abdomen radiating from lower back to pubic symphysis, vomiting and nausea. Diagnosis of ureteric stone was confirmed by Ultrasonography (USG) of abdomen. We gave him local snehana (~local massage with sesame oil), nāḍi svedana (~fomentation), basti (~medicated enema) and oral Ayurveda medicines. Reduction in acute pain was achieved in three hours. Painless removal of stone was also achieved in seven days. Conclusion: This case study provides an example of successful management of acute renal colic with Ayurveda treatment alone and without using any modern analgesics. This case study also gives leads for the experiments on role of gut in the management of pain. Clinical trials on Ayurveda management of acute renal colic are warranted.
{"title":"A case report on ayurvedic management of acute renal colic","authors":"Amit Nakanekar, Pallavi Thote, Niharika Palan, Prashant Deshmukh, J. Gulhane, Amrut S. Salunke","doi":"10.4103/asl.ASL_7_18","DOIUrl":"https://doi.org/10.4103/asl.ASL_7_18","url":null,"abstract":"Background: Acute renal calculus is a common recurrent and emergency condition with an annual incidence of one to two cases per 1000. Lifetime risk of its recurrence is 10–20% in men and 3–5% in women. It is an important cause of acute renal failure. About 12% of the population of India is reported to have urinary stones. Acute attacks are managed by analgesics, antispasmodics and use of Non-steroidal anti-inflammatory drugs (NSAIDs). In this case report we report an acute renal colic case managed by Ayurveda treatment without using any modern analgesics. Case Summary: A 34 year old male patient presented with severe pain in abdomen radiating from lower back to pubic symphysis, vomiting and nausea. Diagnosis of ureteric stone was confirmed by Ultrasonography (USG) of abdomen. We gave him local snehana (~local massage with sesame oil), nāḍi svedana (~fomentation), basti (~medicated enema) and oral Ayurveda medicines. Reduction in acute pain was achieved in three hours. Painless removal of stone was also achieved in seven days. Conclusion: This case study provides an example of successful management of acute renal colic with Ayurveda treatment alone and without using any modern analgesics. This case study also gives leads for the experiments on role of gut in the management of pain. Clinical trials on Ayurveda management of acute renal colic are warranted.","PeriodicalId":7805,"journal":{"name":"Ancient Science of Life","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49346924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Cervical cancer is one of the most common cancers in women worldwide with 122,844 women are diagnosed every year in India. 67,477 die from the disease. High-quality screening with cytology (Pap smear) has markedly reduced mortality from squamous cell cervical cancer. Objective: Efficacy of Kasīsādi Kṣāra Karma followed by Dārvyādi Yonivarti (Vaginal suppository) in cervical cell pathology was evaluated. Materials and Methods: Total 44 patients with cervical erosion diagnosed by Pap smear test were selected from the outpatient department of Prasutitantra and Streeroga, out of which three patients discontinued. The treatment protocol comprised of Kṣāra Karma by Kasīsādi Kṣāra in one sitting followed by Dārvyādi Yoni Varti of 3 gm once at bed time from next day for 21 days. The assessment was done with subjective criteria and Pap-smear after 45 days. Results: The results were observed to be highly significant in clinical features of disease such as yonitaḥ -srāva (77.67%), yoni-kaṇḍu (84.09%), yoni-dāha (87.5%), kaṭi -śūla (73.41%), udara -śūla ( 79.48%), mūtra- dāha (84%), daurbalya ( 72.34%) and area of erosion (85.96%), appearance of erosion (69.32%). Conclusion:Kasīsādi Kṣāra followed by Dārvyādi Yoni Varti was effective in the management of primitive cervical cell pathology.
{"title":"Efficacy of an ayurvedic formulation in the management of primitive cervical cell pathology: An open label clinical trial","authors":"Amit V. Rupapara, S. Donga, Dei Laxmipriya","doi":"10.4103/asl.ASL_89_17","DOIUrl":"https://doi.org/10.4103/asl.ASL_89_17","url":null,"abstract":"Background: Cervical cancer is one of the most common cancers in women worldwide with 122,844 women are diagnosed every year in India. 67,477 die from the disease. High-quality screening with cytology (Pap smear) has markedly reduced mortality from squamous cell cervical cancer. Objective: Efficacy of Kasīsādi Kṣāra Karma followed by Dārvyādi Yonivarti (Vaginal suppository) in cervical cell pathology was evaluated. Materials and Methods: Total 44 patients with cervical erosion diagnosed by Pap smear test were selected from the outpatient department of Prasutitantra and Streeroga, out of which three patients discontinued. The treatment protocol comprised of Kṣāra Karma by Kasīsādi Kṣāra in one sitting followed by Dārvyādi Yoni Varti of 3 gm once at bed time from next day for 21 days. The assessment was done with subjective criteria and Pap-smear after 45 days. Results: The results were observed to be highly significant in clinical features of disease such as yonitaḥ -srāva (77.67%), yoni-kaṇḍu (84.09%), yoni-dāha (87.5%), kaṭi -śūla (73.41%), udara -śūla ( 79.48%), mūtra- dāha (84%), daurbalya ( 72.34%) and area of erosion (85.96%), appearance of erosion (69.32%). Conclusion:Kasīsādi Kṣāra followed by Dārvyādi Yoni Varti was effective in the management of primitive cervical cell pathology.","PeriodicalId":7805,"journal":{"name":"Ancient Science of Life","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44740258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: The vaiśvānaracūrṇa is an Ayurvedic formulation which finds its mention in the Ayurvedic Formulary of India. There are five natural ingredients in this preparation. Rheumatoid arthritis and other medical complications are treated with it. The cūrṇa formulations are challenging to dose precisely, and patient compliance is generally low. Aim: The study was designed to formulate and standardize of vaiśvānaracūrṇa tablet to improve patient compliance. Materials and Methods: The present study was carried out to characterize the coated tablet preparation of vaiśvānaracūrṇa, a multiherbal formulation on the basis of pharmacognostic, physichochemical, microbiological, pharmaceutical, spectroscopic, and chromatographic parameters to identify the quality and purity of the tablets. Results: The selected tablet formulation (F5) was found within the limits of all pharmacopoeial parameters. Conclusion: The methods presented in this study can be used for production of this formulation at large scale to get better results in terms of quality, safety, and better therapeutic efficacy.
{"title":"Formulation, standardization, and evaluation of vaiśvānaracūrṇa Tablet","authors":"Rishi Kumar, S. Samajdar, R. Mazumder, A. Chandra","doi":"10.4103/asl.asl_97_22","DOIUrl":"https://doi.org/10.4103/asl.asl_97_22","url":null,"abstract":"Background: The vaiśvānaracūrṇa is an Ayurvedic formulation which finds its mention in the Ayurvedic Formulary of India. There are five natural ingredients in this preparation. Rheumatoid arthritis and other medical complications are treated with it. The cūrṇa formulations are challenging to dose precisely, and patient compliance is generally low. Aim: The study was designed to formulate and standardize of vaiśvānaracūrṇa tablet to improve patient compliance. Materials and Methods: The present study was carried out to characterize the coated tablet preparation of vaiśvānaracūrṇa, a multiherbal formulation on the basis of pharmacognostic, physichochemical, microbiological, pharmaceutical, spectroscopic, and chromatographic parameters to identify the quality and purity of the tablets. Results: The selected tablet formulation (F5) was found within the limits of all pharmacopoeial parameters. Conclusion: The methods presented in this study can be used for production of this formulation at large scale to get better results in terms of quality, safety, and better therapeutic efficacy.","PeriodicalId":7805,"journal":{"name":"Ancient Science of Life","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45633331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Ayuphenomics: Is it already a part of ayurveda epistemology?","authors":"S. Eranezhath","doi":"10.4103/asl.asl_36_23","DOIUrl":"https://doi.org/10.4103/asl.asl_36_23","url":null,"abstract":"","PeriodicalId":7805,"journal":{"name":"Ancient Science of Life","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46925939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction: Ayurveda has mentioned different classical formulations in various disorders among Kashaya one having its own importance in internal as well as external use in the management of diseases. The procedure needs more time and patience. Because of this hectic life, many times are not following the procedure correctly, which leads to less results of the formulation. Due to modified life, everyone wants to easy and quick preparations. Objective: The objective of this study was to prepare Kashaya by the classical method and cooker method and analysis of Kashaya. Methodology: In this study, Kashaya was prepared using the classical and pressure cooker method and was analyzed for physicochemical, phytochemical, and pharmacognestically to assess the changes. Results: Physicochemical, phytochemical, and pharmacognostic results of Kashaya were similar. Conclusion: The pressure cooker method is a user-friendly procedure with less time consuming and fuel. Physicochemical parameters are similar to the classical method. The classical method can be replaced with the pressure cooker method.
{"title":"Comparative pharmaceutical study of erandamoola kashaya by classical and pressure cooker method and its analytico: Pharmacognostic study","authors":"Veena B. Kupati, Shrinivas Buduru","doi":"10.4103/asl.asl_76_21","DOIUrl":"https://doi.org/10.4103/asl.asl_76_21","url":null,"abstract":"Introduction: Ayurveda has mentioned different classical formulations in various disorders among Kashaya one having its own importance in internal as well as external use in the management of diseases. The procedure needs more time and patience. Because of this hectic life, many times are not following the procedure correctly, which leads to less results of the formulation. Due to modified life, everyone wants to easy and quick preparations. Objective: The objective of this study was to prepare Kashaya by the classical method and cooker method and analysis of Kashaya. Methodology: In this study, Kashaya was prepared using the classical and pressure cooker method and was analyzed for physicochemical, phytochemical, and pharmacognestically to assess the changes. Results: Physicochemical, phytochemical, and pharmacognostic results of Kashaya were similar. Conclusion: The pressure cooker method is a user-friendly procedure with less time consuming and fuel. Physicochemical parameters are similar to the classical method. The classical method can be replaced with the pressure cooker method.","PeriodicalId":7805,"journal":{"name":"Ancient Science of Life","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46214228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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