Gall bladder (GB) is an important organ under the biliary system. Cholelithiasis (gall stones) is one of the most common among all conditions affecting GB. Surgery (cholecystectomy) is the most common form of treatment for cholelithiasis. Surgically removing of cholelithiasis requires the removal of an entire organ. After the removal of GB, the patient becomes away from the normal physiological life and feels abdominal discomfort with indigestion. This has led to a growing interest in nonsurgical treatments for cholelithiasis. In the present case, the patient was suffering with abdominal pain, nausea, loos stool after every meal. The patient was given systemic virecana and after that medicine was given for 3 months and all symptoms with GB stone were disappeared. In Ayurveda, taking an idea from aśmari (Calculi), one can frame its pathology like in cholelithiasis excessive kapha reaches at pittāśaya (GB) and solidifies there with rūkṣa guṇa (dry property) of vāta to turns into stone form. virecana (therapeutic purgation) is the best treatment for this, as the site is pittāśaya. virecana is indicated for all doṣa. Efficacy of virecana karma in reference to the management of GB stone has not been well documented till date. Hence, an attempt has been made to see the efficacy of virecana karma in cholelithiasis.
{"title":"Management of cholelithiasis (Gall Bladder Stone) through virecana (Therapeutic Purgation): A case study","authors":"Shital Bhagiya, T. Kumar, N. Bhatt, B. Thakar","doi":"10.4103/asl.ASL_113_17","DOIUrl":"https://doi.org/10.4103/asl.ASL_113_17","url":null,"abstract":"Gall bladder (GB) is an important organ under the biliary system. Cholelithiasis (gall stones) is one of the most common among all conditions affecting GB. Surgery (cholecystectomy) is the most common form of treatment for cholelithiasis. Surgically removing of cholelithiasis requires the removal of an entire organ. After the removal of GB, the patient becomes away from the normal physiological life and feels abdominal discomfort with indigestion. This has led to a growing interest in nonsurgical treatments for cholelithiasis. In the present case, the patient was suffering with abdominal pain, nausea, loos stool after every meal. The patient was given systemic virecana and after that medicine was given for 3 months and all symptoms with GB stone were disappeared. In Ayurveda, taking an idea from aśmari (Calculi), one can frame its pathology like in cholelithiasis excessive kapha reaches at pittāśaya (GB) and solidifies there with rūkṣa guṇa (dry property) of vāta to turns into stone form. virecana (therapeutic purgation) is the best treatment for this, as the site is pittāśaya. virecana is indicated for all doṣa. Efficacy of virecana karma in reference to the management of GB stone has not been well documented till date. Hence, an attempt has been made to see the efficacy of virecana karma in cholelithiasis.","PeriodicalId":7805,"journal":{"name":"Ancient Science of Life","volume":"38 1","pages":"73 - 76"},"PeriodicalIF":0.0,"publicationDate":"2018-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43193327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Necrosis of tissue has become the challenging case, considering the difficulties of its management to bring back the normalcy of dead tissue. Treatment choice in surgery ends up with amputation of the affected part which leads to depression to a patient. In Ayurveda, posttraumatic necrosis can be correlated with picchita vraṇa (crushed injury) which is included under āgantuja vraṇa (traumatic injury). In this case report, an interesting case of posttraumatic necrotic changes of the right index finger was presented to us at the Outpatient Department of Ayurved Research Hospital. There was symptom of aggravated pain along with gradual discoloration of the tip of the index finger to a necrotic condition. Naturally, such cases have a very poor prognosis. Considering the pathological changes in this case, jalaukāvacaraṇa (Hirudo therapy) procedure has been taken up for the management. In the 1st week, three leeches were applied after every 3 days, and later on, after every 7 days, further three sittings of leech application were done. Leech absorbed impure blood which results in neovascularization and reconstruction of the necrotic tissue. Antiplatelet and antithrombin action of hirudin present in saliva of leech recanalizes the thrombus or clot at the injured part. The patient was cured completely and survived the finger from amputation with jalaukāvacaraṇa (Hirudo therapy).
{"title":"Jalaukāvacaraṇa (Hirudo therapy) in the management of necrosed index finger due to crush injury","authors":"D. Sambhaji, Komang Sudarmi","doi":"10.4103/asl.ASL_163_16","DOIUrl":"https://doi.org/10.4103/asl.ASL_163_16","url":null,"abstract":"Necrosis of tissue has become the challenging case, considering the difficulties of its management to bring back the normalcy of dead tissue. Treatment choice in surgery ends up with amputation of the affected part which leads to depression to a patient. In Ayurveda, posttraumatic necrosis can be correlated with picchita vraṇa (crushed injury) which is included under āgantuja vraṇa (traumatic injury). In this case report, an interesting case of posttraumatic necrotic changes of the right index finger was presented to us at the Outpatient Department of Ayurved Research Hospital. There was symptom of aggravated pain along with gradual discoloration of the tip of the index finger to a necrotic condition. Naturally, such cases have a very poor prognosis. Considering the pathological changes in this case, jalaukāvacaraṇa (Hirudo therapy) procedure has been taken up for the management. In the 1st week, three leeches were applied after every 3 days, and later on, after every 7 days, further three sittings of leech application were done. Leech absorbed impure blood which results in neovascularization and reconstruction of the necrotic tissue. Antiplatelet and antithrombin action of hirudin present in saliva of leech recanalizes the thrombus or clot at the injured part. The patient was cured completely and survived the finger from amputation with jalaukāvacaraṇa (Hirudo therapy).","PeriodicalId":7805,"journal":{"name":"Ancient Science of Life","volume":"38 1","pages":"68 - 72"},"PeriodicalIF":0.0,"publicationDate":"2018-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47347697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Haqeeq Ahmad, A. Wadud, G. Sofi, N. Jahan, Hamiduddin
Objective: Kushta (calx) is a well-known dosage form of Unani medicine but has always been condemned by scientific fraternity and even some traditionalists because of certain issues associated with Kushta such as safety, lack of scientific data, adverse effects, and complicated method of preparation. Very few studies are carried out on Kushta in Unani medicine and no study has explored its mechanism of action on scientific basis that may be acceptable widely. Methodology: In this study, the review was done regarding the concept of Kushta in Unani medicine, and studies carried out so far along with a possible explanation of the effectiveness, classical method of preparation, superiority of Kushta over other dosage forms, challenges with use of Kushta, idea of use of herbs in making Kushta, and other issues. Literature on Kushta was collected from classical Unani books and papers published in various journals and analyzed. We found that very few scientific studies have been carried out on Kushta in Unani medicine and that too on certain set topics. Most studies are on physicochemical standardization of Kushta. Conclusion: Study revealed that the research carried out so far is not satisfactory. They are also of preliminary nature. Advance toxicological and pharmacological studies are required to generate strong evidences for wide acceptability, safety, and efficacy of Kushta.
{"title":"Concept of Kushta (calx) and studies carried out on Kushta in unani medicine","authors":"Haqeeq Ahmad, A. Wadud, G. Sofi, N. Jahan, Hamiduddin","doi":"10.4103/asl.ASL_93_19","DOIUrl":"https://doi.org/10.4103/asl.ASL_93_19","url":null,"abstract":"Objective: Kushta (calx) is a well-known dosage form of Unani medicine but has always been condemned by scientific fraternity and even some traditionalists because of certain issues associated with Kushta such as safety, lack of scientific data, adverse effects, and complicated method of preparation. Very few studies are carried out on Kushta in Unani medicine and no study has explored its mechanism of action on scientific basis that may be acceptable widely. Methodology: In this study, the review was done regarding the concept of Kushta in Unani medicine, and studies carried out so far along with a possible explanation of the effectiveness, classical method of preparation, superiority of Kushta over other dosage forms, challenges with use of Kushta, idea of use of herbs in making Kushta, and other issues. Literature on Kushta was collected from classical Unani books and papers published in various journals and analyzed. We found that very few scientific studies have been carried out on Kushta in Unani medicine and that too on certain set topics. Most studies are on physicochemical standardization of Kushta. Conclusion: Study revealed that the research carried out so far is not satisfactory. They are also of preliminary nature. Advance toxicological and pharmacological studies are required to generate strong evidences for wide acceptability, safety, and efficacy of Kushta.","PeriodicalId":7805,"journal":{"name":"Ancient Science of Life","volume":"38 1","pages":"37 - 44"},"PeriodicalIF":0.0,"publicationDate":"2018-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46805427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Jasminum humile L. is one of the traditional medicinal plants from Oleaceae family. It is abundantly available in Afghanistan, Pakistan, Nepal, Burma, the Himalayas, and southwest China. The tea of leaves and barks are used conventionally in the treatment of various diseases such as central nervous system disorder, anti-inflammatory, and antiseptic. Aim: The present study was undertaken to investigate the anxiolytic effect of methanolic extract of J. humile L. leaves (MEJHL). Materials and Methods: Anxiolytic activity of J. humile L. leaves extracts were evaluated using Elevated Plus-Maze (EPM) and light/dark exploration models. The motor coordination and sedative effect were also observed using Rota Rod apparatus, actophotometer, and ketamine-induced sleeping time, respectively. Brain neurotransmitters like GABA level were estimated by validated methods. Results: From the acute toxicity studies, extracts of J. humile L. leaves were found to be nontoxic. Among all extracts, the only methanolic extract showed significant (P < 0.05) anxiolytic activity. Preliminary phytochemical screening revealed the presence of carbohydrates, flavonoids, and alkaloids in the MEJHL. The results of anxiolytic models clearly depicted that MEJHL at the dose of 200 mg/kg significantly (P < 0.05) increased the number of entries and the average time spent in the open arms and light compartment of the EPM and light/dark models, respectively. In the case of motor coordination activity, the MEJHL does not cause any significant effect (at any dose) on the latency to fall off from the Rota Rod bar compared to the control group. Moreover, no remarkable effects in actophotometer and on ketamine-induced sleep latency and total sleeping time induced by ketamine was observed. Results of neurotransmitter estimation in the whole brain and the cerebellum revealed the increased concentration of GABA was similar to standard drug diazepam. Conclusions: The presence of alkaloids in the methanolic extract of this plant can serve as a potential resource for natural psychotherapeutic agents against anxiety with less sedation.
背景：胡茉莉是木犀科传统药用植物之一。它在阿富汗、巴基斯坦、尼泊尔、缅甸、喜马拉雅山和中国西南部随处可见。茶叶和树皮通常用于治疗各种疾病，如中枢神经系统疾病、抗炎症和防腐剂。目的：研究胡麻叶甲醇提取物（MEJHL）的抗焦虑作用。材料和方法：采用Elevated Plus Maze（EPM）和光/暗探索模型评价胡麻叶提取物的解焦虑活性。使用Rota-Rod装置、动力计和氯胺酮诱导的睡眠时间分别观察运动协调和镇静效果。大脑神经递质如GABA水平通过验证的方法估计。结果：从急性毒性研究中发现，胡麻叶提取物是无毒的。在所有提取物中，只有甲醇提取物表现出显著的抗焦虑活性（P<0.05）。初步的植物化学筛选揭示了MEJHL中存在碳水化合物、黄酮类化合物和生物碱。抗焦虑模型的结果清楚地表明，200mg/kg剂量的MEJHL分别显著增加了进入EPM和亮/暗模型的开放臂和亮区的次数和平均时间（P<0.05）。在运动协调活动的情况下，与对照组相比，MEJHL对Rota棒脱落的潜伏期没有任何显著影响（在任何剂量下）。此外，在动作光度计和氯胺酮诱导的睡眠潜伏期和总睡眠时间方面没有观察到显著的影响。整个大脑和小脑的神经递质估计结果显示，GABA浓度的增加与标准药物地西泮相似。结论：该植物甲醇提取物中存在生物碱，可作为一种潜在的天然抗焦虑药物来源，镇静效果较差。
{"title":"Methanolic extract of Jasminum humile L. leaves possess anxiolytic activity mediated via the gabaergic system in the central nervous system of mice","authors":"Parminder Nain, M. Bhatia, Jaspreet Kaur","doi":"10.4103/asl.ASL_37_20","DOIUrl":"https://doi.org/10.4103/asl.ASL_37_20","url":null,"abstract":"Background: Jasminum humile L. is one of the traditional medicinal plants from Oleaceae family. It is abundantly available in Afghanistan, Pakistan, Nepal, Burma, the Himalayas, and southwest China. The tea of leaves and barks are used conventionally in the treatment of various diseases such as central nervous system disorder, anti-inflammatory, and antiseptic. Aim: The present study was undertaken to investigate the anxiolytic effect of methanolic extract of J. humile L. leaves (MEJHL). Materials and Methods: Anxiolytic activity of J. humile L. leaves extracts were evaluated using Elevated Plus-Maze (EPM) and light/dark exploration models. The motor coordination and sedative effect were also observed using Rota Rod apparatus, actophotometer, and ketamine-induced sleeping time, respectively. Brain neurotransmitters like GABA level were estimated by validated methods. Results: From the acute toxicity studies, extracts of J. humile L. leaves were found to be nontoxic. Among all extracts, the only methanolic extract showed significant (P < 0.05) anxiolytic activity. Preliminary phytochemical screening revealed the presence of carbohydrates, flavonoids, and alkaloids in the MEJHL. The results of anxiolytic models clearly depicted that MEJHL at the dose of 200 mg/kg significantly (P < 0.05) increased the number of entries and the average time spent in the open arms and light compartment of the EPM and light/dark models, respectively. In the case of motor coordination activity, the MEJHL does not cause any significant effect (at any dose) on the latency to fall off from the Rota Rod bar compared to the control group. Moreover, no remarkable effects in actophotometer and on ketamine-induced sleep latency and total sleeping time induced by ketamine was observed. Results of neurotransmitter estimation in the whole brain and the cerebellum revealed the increased concentration of GABA was similar to standard drug diazepam. Conclusions: The presence of alkaloids in the methanolic extract of this plant can serve as a potential resource for natural psychotherapeutic agents against anxiety with less sedation.","PeriodicalId":7805,"journal":{"name":"Ancient Science of Life","volume":"38 1","pages":"45 - 52"},"PeriodicalIF":0.0,"publicationDate":"2018-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44884482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Santosh Mudakappagol, A. Wali, H. Salma, Ramesh S. Killedar
Buerger's disease is associated with ulcers in the extremities with the possibility of amputation. The prevalence of the disease among all patients with peripheral arterial disease ranged 5%–10%. Heavy cigarette smoking has been implicated the main etiology and only treatment that has been shown to be effective is complete abstention from smoking. In spite of this, the disease progresses in up to 30% of cases and finally results in limb amputation. Here, it is a case report of a 45-year-old male patient who came with complaints of severe pain and nonhealing arterial ulcer over the right great toe for 3 months with a diagnosis of Buerger's disease. The present case scenario is clinically correlated to gambhīra vātarakta, owing to the mārgāvaraṇa (obstruction) pathology and managed effectively with mañjiṣṭhādi kṣārabasti (Medicated enema), raktamokṣaṇa (bloodletting), and śamana auṣadhi (oral medications) which hoarded him from amputation.
伯格氏病与可能截肢的四肢溃疡有关。该疾病在所有外周动脉疾病患者中的患病率在5%-10%之间。重度吸烟被认为是主要病因，唯一被证明有效的治疗方法是完全戒烟。尽管如此，这种疾病在高达30%的病例中发展，最终导致截肢。这是一例45岁男性患者的病例报告，他主诉右大脚趾剧烈疼痛和动脉溃疡持续3个月，诊断为Buerger病。由于mārgāvaraṇa（梗阻）病理学，目前的病例场景在临床上与gambhīra vātarakta相关，并通过mañjiṣṣārabasti（药物灌肠），raktamokṣ一ṇa（放血）和śamana aus adhi（口服药物）使他免于截肢。
{"title":"An ayurvedic management of chronic nonhealing ulcer in buerger's disease w.s.r. to gambhīra vātarakta: A case study","authors":"Santosh Mudakappagol, A. Wali, H. Salma, Ramesh S. Killedar","doi":"10.4103/asl.ASL_134_17","DOIUrl":"https://doi.org/10.4103/asl.ASL_134_17","url":null,"abstract":"Buerger's disease is associated with ulcers in the extremities with the possibility of amputation. The prevalence of the disease among all patients with peripheral arterial disease ranged 5%–10%. Heavy cigarette smoking has been implicated the main etiology and only treatment that has been shown to be effective is complete abstention from smoking. In spite of this, the disease progresses in up to 30% of cases and finally results in limb amputation. Here, it is a case report of a 45-year-old male patient who came with complaints of severe pain and nonhealing arterial ulcer over the right great toe for 3 months with a diagnosis of Buerger's disease. The present case scenario is clinically correlated to gambhīra vātarakta, owing to the mārgāvaraṇa (obstruction) pathology and managed effectively with mañjiṣṭhādi kṣārabasti (Medicated enema), raktamokṣaṇa (bloodletting), and śamana auṣadhi (oral medications) which hoarded him from amputation.","PeriodicalId":7805,"journal":{"name":"Ancient Science of Life","volume":"38 1","pages":"77 - 81"},"PeriodicalIF":0.0,"publicationDate":"2018-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48551389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"SAMANVAYA 2018: Conference on integrative diabetology – Present trends in diabetes care","authors":"D. Patil, N. Patil, L. Sunitha","doi":"10.4103/asl.asl_11_19","DOIUrl":"https://doi.org/10.4103/asl.asl_11_19","url":null,"abstract":"","PeriodicalId":7805,"journal":{"name":"Ancient Science of Life","volume":"38 1","pages":"32 - 33"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42098523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lumbar disc disease (LDD) is a common cause of chronic or recurrent low back and leg pain most likely to occur at the L4-L5 and L5-S1 levels. The pain may be located in the lower back only or may refer to the leg, buttocks, or hip. There is less improvement with modern medicines and recurrence due to surgical decompression. Various Ayurvedic drugs along with required pañcakarma procedures have been proved useful for these manifestations. We present a case of LDD (kaṭi asthi sandhi gata vᾱta) having acute severe lower back pain above left hip joint radiating towards the left thigh and calf muscle since 14 days. His visual analog scale (VAS) score was 10 when he arrived at the hospital. The case was treated for 3 months with a combination of ᾱyurvedic drugs and pañcakarma procedures. Ayurvedic treatments, in this case, were directed toward alleviating pain and to reduce disability to walk. The patient was considered suffering from kaṭi asthi sandhi gata vᾱta (vᾱtaj disorder involving lumbar region) and was given harītakī cῡrṇa 5 g with lukewarm water on the first night for vᾱtᾱnulomana. ekāṅgavīra rasa, punarnavādi maṇḍūra, rᾱsnᾱsaptaka kvᾱtha, balāriṣṭa, ajamodādi cūrṇa, orally have been given with saindhavādi taila for local application for 3 months. For śodhana cikitsā sarvāṅga abhyaṅga and sarvāṅga patra piṇḍa svedana (PPS), kaṭi basti with pañcaguṇa taila and kᾱla basti (nirῡha with rᾱsnᾱ eraṇḍādi kvᾱtha and anuvᾱsana with dhānvantaraṃ taila) for 16 days is given. Patient's condition was assessed for symptoms of kaṭi asthi sandhi gata vᾱta and VAS scale for pain, Fukushima lumbar spinal stenosis scale-25, and 6 min walking test before and after the treatment which showed substantial improvement. This study shows that the cases of lumbar disc disease which may be successfully managed with ayurvedic treatment.
腰椎间盘疾病(LDD)是慢性或复发性腰背部和腿部疼痛的常见原因，最可能发生在L4-L5和L5-S1水平。疼痛可仅发生在下背部，也可累及腿部、臀部或臀部。现代药物治疗改善较少，手术减压后复发。各种阿育吠陀药物以及所需的pañcakarma程序已被证明对这些表现有用。我们报告一例LDD (kaṭi哮喘sandhi gata v□ta)，左髋关节以上急性严重腰痛，向左大腿和小腿肌肉放射14天。当他到达医院时，他的视觉模拟评分(VAS)为10分。该病例接受了3个月的联合治疗，使用了育吠陀药物和pañcakarma程序。在这种情况下，阿育吠陀疗法的目的是减轻疼痛，减少行走障碍。患者考虑为kaṭi哮喘sandhi gata v□ta(累及腰部的v□taj紊乱)，于首晚给予har taki ā c ā rṇa 5 g加温水治疗v□t□nulomana。Ekāṅgavīra rasa, punarnavādi maṇḍūra, r□sn□saptaka kv□tha, balāriṣṭa, ajamodādi cūrṇa，口服，配合saindhavādi taila局部应用3个月。对于śodhana cikitsza sarvāṅga abhyaṅga和sarvāṅga patra piṇḍa svedana (PPS)，给予kaṭi basti with pañcaguṇa taila和k æ la basti (nir ha with r sn eraṇḍādi kv tha和anuv sana with dhānvantaraṃ taila) 16天。治疗前后对患者进行kaṭi哮喘病症状评估、疼痛VAS评分、福岛腰椎管狭窄量表-25分、6 min步行测试，均有明显改善。本研究表明，病例腰椎间盘疾病，这可能是成功的管理与阿育吠陀治疗。
{"title":"Ayurvedic management of lumbar disc disease - A case report","authors":"Vaidya Pandey, N. Kaushik","doi":"10.4103/asl.asl_197_17","DOIUrl":"https://doi.org/10.4103/asl.asl_197_17","url":null,"abstract":"Lumbar disc disease (LDD) is a common cause of chronic or recurrent low back and leg pain most likely to occur at the L4-L5 and L5-S1 levels. The pain may be located in the lower back only or may refer to the leg, buttocks, or hip. There is less improvement with modern medicines and recurrence due to surgical decompression. Various Ayurvedic drugs along with required pañcakarma procedures have been proved useful for these manifestations. We present a case of LDD (kaṭi asthi sandhi gata vᾱta) having acute severe lower back pain above left hip joint radiating towards the left thigh and calf muscle since 14 days. His visual analog scale (VAS) score was 10 when he arrived at the hospital. The case was treated for 3 months with a combination of ᾱyurvedic drugs and pañcakarma procedures. Ayurvedic treatments, in this case, were directed toward alleviating pain and to reduce disability to walk. The patient was considered suffering from kaṭi asthi sandhi gata vᾱta (vᾱtaj disorder involving lumbar region) and was given harītakī cῡrṇa 5 g with lukewarm water on the first night for vᾱtᾱnulomana. ekāṅgavīra rasa, punarnavādi maṇḍūra, rᾱsnᾱsaptaka kvᾱtha, balāriṣṭa, ajamodādi cūrṇa, orally have been given with saindhavādi taila for local application for 3 months. For śodhana cikitsā sarvāṅga abhyaṅga and sarvāṅga patra piṇḍa svedana (PPS), kaṭi basti with pañcaguṇa taila and kᾱla basti (nirῡha with rᾱsnᾱ eraṇḍādi kvᾱtha and anuvᾱsana with dhānvantaraṃ taila) for 16 days is given. Patient's condition was assessed for symptoms of kaṭi asthi sandhi gata vᾱta and VAS scale for pain, Fukushima lumbar spinal stenosis scale-25, and 6 min walking test before and after the treatment which showed substantial improvement. This study shows that the cases of lumbar disc disease which may be successfully managed with ayurvedic treatment.","PeriodicalId":7805,"journal":{"name":"Ancient Science of Life","volume":"38 1","pages":"26 - 31"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43818288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Herbo-mineral preparations used in Ayurveda are seen as a matter of concern nowadays; especially for containing metals such as mercury, lead, and copper. One of such formulations is hṛdayārṇava rasa (HR) which contains black sulfide of mercury and tāmra bhasma. Till date, no safety profile of this formulation is available. In the present study, acute oral toxicity of HR prepared from tāmra bhasma in aśodhita and śodhita form was evaluated to provide the safety profile on acute administration. Materials and Methods: HR prepared from śodhita tāmra bhasma (STBHR) and HR prepared from aśodhita tāmra bhasma (ATBHR) was prepared as per the classical reference. Acute toxicity test was evaluated as per OECD 425 guidelines with 2000 mg/kg as a limit test. Fifteen Wistar strain albino female rats (Rattus norvegicus) were randomly divided into three groups of five animals each. One group served as control, and other two served as experimental groups. Test formulation was administered orally to overnight fasted female rats, and detailed behavioral changes and mortality were recorded for 14 days. Parameters such as body weight, hematological and biochemical parameters, and histopathological study of some important organs were assessed. Results: No significant changes in behavior, mortality, body weight, and hematological parameters were observed in all the animals. Some biochemical parameters such as blood urea, alkaline phosphatase, serum glutamic oxaloacetic transaminase, and serum glutamic pyruvic transaminase were affected in both the test drugs. In histopathological study, sections of liver and kidney showed some degenerative changes; comparatively more in ATBHR. Conclusion: The results of the study demonstrate that LD50 of both the test drugs are higher than 2000 mg/kg. It was concluded that both the test drugs at higher dose levels can cause hepatorenal toxicity. However, further chronic toxicity evaluation is necessary to establish the safety profile on chronic administration.
{"title":"Acute oral toxicity evaluation of Hridayarnava Rasa (A Herbo-Mineral Ayurvedic Formulation) prepared from aśodhita and śodhita tāmra bhasma","authors":"C. Jagtap, M. Nariya, V. Shukla, P. Prajapati","doi":"10.4103/asl.asl_14_18","DOIUrl":"https://doi.org/10.4103/asl.asl_14_18","url":null,"abstract":"Background: Herbo-mineral preparations used in Ayurveda are seen as a matter of concern nowadays; especially for containing metals such as mercury, lead, and copper. One of such formulations is hṛdayārṇava rasa (HR) which contains black sulfide of mercury and tāmra bhasma. Till date, no safety profile of this formulation is available. In the present study, acute oral toxicity of HR prepared from tāmra bhasma in aśodhita and śodhita form was evaluated to provide the safety profile on acute administration. Materials and Methods: HR prepared from śodhita tāmra bhasma (STBHR) and HR prepared from aśodhita tāmra bhasma (ATBHR) was prepared as per the classical reference. Acute toxicity test was evaluated as per OECD 425 guidelines with 2000 mg/kg as a limit test. Fifteen Wistar strain albino female rats (Rattus norvegicus) were randomly divided into three groups of five animals each. One group served as control, and other two served as experimental groups. Test formulation was administered orally to overnight fasted female rats, and detailed behavioral changes and mortality were recorded for 14 days. Parameters such as body weight, hematological and biochemical parameters, and histopathological study of some important organs were assessed. Results: No significant changes in behavior, mortality, body weight, and hematological parameters were observed in all the animals. Some biochemical parameters such as blood urea, alkaline phosphatase, serum glutamic oxaloacetic transaminase, and serum glutamic pyruvic transaminase were affected in both the test drugs. In histopathological study, sections of liver and kidney showed some degenerative changes; comparatively more in ATBHR. Conclusion: The results of the study demonstrate that LD50 of both the test drugs are higher than 2000 mg/kg. It was concluded that both the test drugs at higher dose levels can cause hepatorenal toxicity. However, further chronic toxicity evaluation is necessary to establish the safety profile on chronic administration.","PeriodicalId":7805,"journal":{"name":"Ancient Science of Life","volume":"38 1","pages":"3 - 11"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45196290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
gṛdhrasī is a common disorder explained in the context of vāta vyādhi in Ayurveda which greatly interferes with the quality of life. The symptoms of Gṛdhrasī simulate with sciatica. Sciatica is one of the most common causes of pain and disability. The treatment available in modern medicine for sciatica is either conservative such as rest, immobilization, analgesics, anti-inflammatory, or surgical which is not much satisfactory. Here, a case of 58-year-old female complaining of low backache radiating to the left lower limb along with numbness in the distal portion of the left leg and inability to walk without support, is reported. basti cikitsā (medicated enema) is the prime treatment modality among the pañcakarma (five main purifcation procedures) for vāta doṣa and śodhana therapy has already been established being better than śamana, a specific śodhana (purificatory), śamana (palliative) and bṛṃhaṇa (nourishing the tissues and producing anabolic effects) basti was planned in this particular case. The case under the study showed remarkable improvement in almost all the subjective and objective parameters within a span of 8 days of basti and after the follow-up of 1 month. śodhana, śamana, and bṛṃhaṇa Basti were satisfactory on subjective, objective as well as radiographic parameters and can be applied on cases of sciatica after consideration of the doṣas involved.
{"title":"Role of śodhana śamana and bṛṃhaṇa basti in the Management of gṛdhrasī","authors":"Adil Rais, S. Tanwar, A. Thakar","doi":"10.4103/asl.asl_213_16","DOIUrl":"https://doi.org/10.4103/asl.asl_213_16","url":null,"abstract":"gṛdhrasī is a common disorder explained in the context of vāta vyādhi in Ayurveda which greatly interferes with the quality of life. The symptoms of Gṛdhrasī simulate with sciatica. Sciatica is one of the most common causes of pain and disability. The treatment available in modern medicine for sciatica is either conservative such as rest, immobilization, analgesics, anti-inflammatory, or surgical which is not much satisfactory. Here, a case of 58-year-old female complaining of low backache radiating to the left lower limb along with numbness in the distal portion of the left leg and inability to walk without support, is reported. basti cikitsā (medicated enema) is the prime treatment modality among the pañcakarma (five main purifcation procedures) for vāta doṣa and śodhana therapy has already been established being better than śamana, a specific śodhana (purificatory), śamana (palliative) and bṛṃhaṇa (nourishing the tissues and producing anabolic effects) basti was planned in this particular case. The case under the study showed remarkable improvement in almost all the subjective and objective parameters within a span of 8 days of basti and after the follow-up of 1 month. śodhana, śamana, and bṛṃhaṇa Basti were satisfactory on subjective, objective as well as radiographic parameters and can be applied on cases of sciatica after consideration of the doṣas involved.","PeriodicalId":7805,"journal":{"name":"Ancient Science of Life","volume":"38 1","pages":"12 - 19"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41438284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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