Pub Date : 2025-03-01Epub Date: 2024-05-10DOI: 10.1097/PHM.0000000000002546
Chantal Nguyen, Katherine Lumetta, Raymond Chou
{"title":"Subscapularis Recess Ganglion Cyst: An Uncommon Cause for Anterior Shoulder Pain in a Recreational Tennis Player.","authors":"Chantal Nguyen, Katherine Lumetta, Raymond Chou","doi":"10.1097/PHM.0000000000002546","DOIUrl":"10.1097/PHM.0000000000002546","url":null,"abstract":"","PeriodicalId":7850,"journal":{"name":"American Journal of Physical Medicine & Rehabilitation","volume":" ","pages":"e45-e46"},"PeriodicalIF":2.2,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140896666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-03-01Epub Date: 2024-09-04DOI: 10.1097/PHM.0000000000002640
Rachel L Bevins
Objective: The aim of this study was to compare overall performance and performance within the individual disciplines (e.g., swim) in elite paratriathlon between the ambulatory classes PTS2-5 in men and women.
Design: Data were acquired from the official results of 31 International paratriathlon competitions between 2018 and 2021. A total of 1094 results (men n = 774; women n = 320) were analyzed. One-way analysis of variance was used to compare overall performance time, absolute time spent in each discipline, and percentage of performance time spent in each discipline between sports classes. Pearson's correlation between segment times and overall times were explored.
Results: Overall time was significantly quicker in PTS5 than PTS4 and PTS3 ( P < 0.05), and between PTS4 and PTS3 ( P < 0.05), but no differences were found between PTS3 and PTS2. PTS5 was also quicker than PTS4 and PTS3 ( P < 0.05) across most of the individual discipline times. Cycling comprised the highest percentage of race time in all classes (47.1%-49.6%) and was strongly correlated to overall performance ( r = 0.72-0.91).
Conclusions: Hierarchy in performance times was demonstrated between the less impaired paratriathlon classes, but not between the most impaired PTS2 and PTS3 classes. It may be appropriate for PTS2 and PTS3 to compete together.
{"title":"Paratriathlon Race Performance in Elite Ambulatory Athletes With Physical Impairments.","authors":"Rachel L Bevins","doi":"10.1097/PHM.0000000000002640","DOIUrl":"10.1097/PHM.0000000000002640","url":null,"abstract":"<p><strong>Objective: </strong>The aim of this study was to compare overall performance and performance within the individual disciplines (e.g., swim) in elite paratriathlon between the ambulatory classes PTS2-5 in men and women.</p><p><strong>Design: </strong>Data were acquired from the official results of 31 International paratriathlon competitions between 2018 and 2021. A total of 1094 results (men n = 774; women n = 320) were analyzed. One-way analysis of variance was used to compare overall performance time, absolute time spent in each discipline, and percentage of performance time spent in each discipline between sports classes. Pearson's correlation between segment times and overall times were explored.</p><p><strong>Results: </strong>Overall time was significantly quicker in PTS5 than PTS4 and PTS3 ( P < 0.05), and between PTS4 and PTS3 ( P < 0.05), but no differences were found between PTS3 and PTS2. PTS5 was also quicker than PTS4 and PTS3 ( P < 0.05) across most of the individual discipline times. Cycling comprised the highest percentage of race time in all classes (47.1%-49.6%) and was strongly correlated to overall performance ( r = 0.72-0.91).</p><p><strong>Conclusions: </strong>Hierarchy in performance times was demonstrated between the less impaired paratriathlon classes, but not between the most impaired PTS2 and PTS3 classes. It may be appropriate for PTS2 and PTS3 to compete together.</p>","PeriodicalId":7850,"journal":{"name":"American Journal of Physical Medicine & Rehabilitation","volume":" ","pages":"280-285"},"PeriodicalIF":2.2,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142139052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-03-01Epub Date: 2024-06-24DOI: 10.1097/PHM.0000000000002567
Lizanne Andrag, Lovemore Kunorozva, Wayne Derman, Phoebe Runciman
Objective: Osteoarthritis is a major cause of impairment. Research has shown that individuals with unilateral lower limb amputation are 17 times more likely to develop osteoarthritis on their sound side limb. Therefore, this review aimed to describe similarities and differences in the biomechanical loading variables of individuals with osteoarthritis and those with unilateral lower limb amputation.
Design: Researchers systematically searched PubMed-Medline, EBSCOhost, and Web of Science for articles published between January 1990 and February 2022. Included studies investigated the biomechanical profiles (peak external knee adduction moment; peak external knee flexion moment; ground reaction force; external knee adduction moment loading rate; external knee adduction moment impulse) of both population groups.
Results: A total of 31 articles were included in this review. Only knee adduction moment and knee flexion moment presented similar profiles in both groups, while all other variables were dissimilar. The use of advanced prostheses reduced the loading on the sound side of individuals with unilateral lower limb amputation.
Conclusions: As both knee adduction moment and knee flexion moment are surrogate measures for knee contact forces, interventions need to target these variables to help manage and prevent the development of osteoarthritis. Interventions, particularly for addressing these variables in individuals with unilateral lower limb amputation, should be further investigated in future research.
{"title":"Knee Contact Forces of Individuals With Osteoarthritis and Those With Lower Limb Amputation: A Systematic Review.","authors":"Lizanne Andrag, Lovemore Kunorozva, Wayne Derman, Phoebe Runciman","doi":"10.1097/PHM.0000000000002567","DOIUrl":"10.1097/PHM.0000000000002567","url":null,"abstract":"<p><strong>Objective: </strong>Osteoarthritis is a major cause of impairment. Research has shown that individuals with unilateral lower limb amputation are 17 times more likely to develop osteoarthritis on their sound side limb. Therefore, this review aimed to describe similarities and differences in the biomechanical loading variables of individuals with osteoarthritis and those with unilateral lower limb amputation.</p><p><strong>Design: </strong>Researchers systematically searched PubMed-Medline, EBSCOhost, and Web of Science for articles published between January 1990 and February 2022. Included studies investigated the biomechanical profiles (peak external knee adduction moment; peak external knee flexion moment; ground reaction force; external knee adduction moment loading rate; external knee adduction moment impulse) of both population groups.</p><p><strong>Results: </strong>A total of 31 articles were included in this review. Only knee adduction moment and knee flexion moment presented similar profiles in both groups, while all other variables were dissimilar. The use of advanced prostheses reduced the loading on the sound side of individuals with unilateral lower limb amputation.</p><p><strong>Conclusions: </strong>As both knee adduction moment and knee flexion moment are surrogate measures for knee contact forces, interventions need to target these variables to help manage and prevent the development of osteoarthritis. Interventions, particularly for addressing these variables in individuals with unilateral lower limb amputation, should be further investigated in future research.</p>","PeriodicalId":7850,"journal":{"name":"American Journal of Physical Medicine & Rehabilitation","volume":" ","pages":"210-218"},"PeriodicalIF":2.2,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141449357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-03-01Epub Date: 2024-07-03DOI: 10.1097/PHM.0000000000002577
Jayme S Knutson, Kyle J Chepla, Richard D Wilson, Michael J Fu, Emily C Imka, Shane A Bender, John Chae, Kevin L Kilgore, Niloy Bhadra
Abstract: This feasibility study tested the capability of high-frequency stimulation to block muscle contractions elicited by electrical stimulation of the same nerve proximally. During a tendon lengthening surgery in the forearm, the anterior interosseous nerve was exposed. A specialized nerve cuff electrode was placed around the nerve, and a stimulating probe held on the nerve 1 cm proximal to the cuff electrode delivered pulses of current causing the pronator quadratus muscle to contract. Through the cuff electrode, 20-kHz high-frequency stimulation was delivered to the nerve for 10 secs during proximal stimulation. High-frequency stimulation amplitudes between 5 and 10 mA peak-to-peak were tested to determine which produced complete and partial block of the electrically induced contractions. The minimum high-frequency stimulation amplitude that produced complete block was 8 mA, with lower amplitudes producing partial block. In all trials, muscle contractions resumed immediately after high-frequency stimulation was turned off. This demonstration of high-frequency electrical nerve block is a milestone in the road to clinical implementation of high-frequency stimulation mediated motor block for spasticity.
{"title":"First-in-Human Demonstration of High-Frequency Electrical Motor Nerve Block: Case Report.","authors":"Jayme S Knutson, Kyle J Chepla, Richard D Wilson, Michael J Fu, Emily C Imka, Shane A Bender, John Chae, Kevin L Kilgore, Niloy Bhadra","doi":"10.1097/PHM.0000000000002577","DOIUrl":"10.1097/PHM.0000000000002577","url":null,"abstract":"<p><strong>Abstract: </strong>This feasibility study tested the capability of high-frequency stimulation to block muscle contractions elicited by electrical stimulation of the same nerve proximally. During a tendon lengthening surgery in the forearm, the anterior interosseous nerve was exposed. A specialized nerve cuff electrode was placed around the nerve, and a stimulating probe held on the nerve 1 cm proximal to the cuff electrode delivered pulses of current causing the pronator quadratus muscle to contract. Through the cuff electrode, 20-kHz high-frequency stimulation was delivered to the nerve for 10 secs during proximal stimulation. High-frequency stimulation amplitudes between 5 and 10 mA peak-to-peak were tested to determine which produced complete and partial block of the electrically induced contractions. The minimum high-frequency stimulation amplitude that produced complete block was 8 mA, with lower amplitudes producing partial block. In all trials, muscle contractions resumed immediately after high-frequency stimulation was turned off. This demonstration of high-frequency electrical nerve block is a milestone in the road to clinical implementation of high-frequency stimulation mediated motor block for spasticity.</p>","PeriodicalId":7850,"journal":{"name":"American Journal of Physical Medicine & Rehabilitation","volume":" ","pages":"e37-e40"},"PeriodicalIF":2.2,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141490573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-03-01Epub Date: 2024-06-27DOI: 10.1097/PHM.0000000000002575
Antonio Déniz, Pedro Saavedra, Isabel Marrero, Jaime Hernández
Objective: The aim of the study is to assess the effects on spasticity reduction of the association between focal extracorporeal shock wave therapy and botulinum toxin type A, versus the toxin only in brain injury patients.
Design: Eighteen patients were included. The study had two phases: the first phase was observational, and botulinum toxin type A was used. The second was a prospective, deliberate intervention phase in which the toxin was injected and focal extracorporeal shock wave treatment was added (1 sessions/week, for 3 wks). The patients were followed up in the 1st, 4th, and 6th month, the Ashworth Scale criterion was applied, and for those with lower limb involvement and changes in walking, the 10-meter walk test was used.
Results: Patients treated with toxin only showed a statistically significant improvement in spasticity, with 1 point on the Ashworth Scale from week 5, which disappeared at week 17. However, the combined therapy reduced spasticity by 2 points from week 1 to week 25 ( P < 0.001), with a faster result in the 10-meter gait test ( P = 0.004).
Conclusions: Combined and simultaneous treatment with botulinum toxin and focal extracorporeal shock wave reduced spasticity in a more effective and prolonged way than treatment with botulinum toxin only.
{"title":"Focal Shock Waves Increase Efficacy and Prolong the Effect of Botulinum Toxin on Spasticity in Patients With Brain Injury From Stroke and Multiple Sclerosis.","authors":"Antonio Déniz, Pedro Saavedra, Isabel Marrero, Jaime Hernández","doi":"10.1097/PHM.0000000000002575","DOIUrl":"10.1097/PHM.0000000000002575","url":null,"abstract":"<p><strong>Objective: </strong>The aim of the study is to assess the effects on spasticity reduction of the association between focal extracorporeal shock wave therapy and botulinum toxin type A, versus the toxin only in brain injury patients.</p><p><strong>Design: </strong>Eighteen patients were included. The study had two phases: the first phase was observational, and botulinum toxin type A was used. The second was a prospective, deliberate intervention phase in which the toxin was injected and focal extracorporeal shock wave treatment was added (1 sessions/week, for 3 wks). The patients were followed up in the 1st, 4th, and 6th month, the Ashworth Scale criterion was applied, and for those with lower limb involvement and changes in walking, the 10-meter walk test was used.</p><p><strong>Results: </strong>Patients treated with toxin only showed a statistically significant improvement in spasticity, with 1 point on the Ashworth Scale from week 5, which disappeared at week 17. However, the combined therapy reduced spasticity by 2 points from week 1 to week 25 ( P < 0.001), with a faster result in the 10-meter gait test ( P = 0.004).</p><p><strong>Conclusions: </strong>Combined and simultaneous treatment with botulinum toxin and focal extracorporeal shock wave reduced spasticity in a more effective and prolonged way than treatment with botulinum toxin only.</p>","PeriodicalId":7850,"journal":{"name":"American Journal of Physical Medicine & Rehabilitation","volume":" ","pages":"226-230"},"PeriodicalIF":2.2,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141454694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-03-01Epub Date: 2024-07-03DOI: 10.1097/PHM.0000000000002552
Elisabetta Zampogna, Federico Mattia Oliva, Matteo Johann Del Furia, Claudio Cordani, Stefano Giuseppe Lazzarini, Chiara Arienti
Objective: The aim of the study is to evaluate the effectiveness of pulmonary rehabilitation programs and other rehabilitation interventions in adults with asthma.
Design: This is a systematic review and meta-analysis.
Results: MEDLINE (PubMed), Embase, Cumulative Index to Nursing & Allied Health Literature, and CENTRAL were searched from inception to 31 May 2023. PROSPERO registration number: CRD42022331440. Thirty-six randomized controlled trials were analyzed, and only 26 were pooled in the meta-analysis because of the heterogeneity of comparisons and outcomes across the studies. Pulmonary rehabilitation, compared with education associated with breathing exercises, may result in little to no difference in the Asthma Quality of Life Questionnaire (mean difference 0.01 score, 95% confidence interval = -0.48 to 0.50, 163 participants, three studies, low certainty).
Conclusions: Our findings show that pulmonary rehabilitation, compared with education associated with breathing exercises, may result in little to no difference in the impact of asthma on health-related quality of life. Overall, the certainty of evidence was low or very low preventing any firm conclusion on the effects of single or combined rehabilitation interventions.
目的评估肺康复(PR)项目和其他康复干预措施对成人哮喘患者的有效性:设计:系统回顾和荟萃分析:检索了从开始到 2023 年 5 月 31 日的 MEDLINE (PubMed)、EMBASE、Cumulative Index to Nursing & Allied Health Literature 和 CENTRAL。PROSPERO 注册号:CRD42022331440。共分析了 36 项随机对照试验 (RCT),由于各项研究的比较和结果存在异质性,因此在荟萃分析中仅对 26 项试验进行了汇总。肺康复与与呼吸练习相关的教育相比,在哮喘生活质量问卷(AQLQ)上可能几乎没有差异(平均差异为0.01分,95%置信区间为-0.48至0.50,163名参与者,三项研究,低确定性):我们的研究结果表明,肺康复与与呼吸练习相关的教育相比,在哮喘对健康相关生活质量的影响方面可能几乎没有差别。总体而言,由于证据的确定性较低或非常低,因此无法就单一或综合康复干预措施的效果得出任何确定的结论。
{"title":"Effectiveness of Rehabilitation Interventions in Adults With Asthma: A Systematic Review and Meta-analysis.","authors":"Elisabetta Zampogna, Federico Mattia Oliva, Matteo Johann Del Furia, Claudio Cordani, Stefano Giuseppe Lazzarini, Chiara Arienti","doi":"10.1097/PHM.0000000000002552","DOIUrl":"10.1097/PHM.0000000000002552","url":null,"abstract":"<p><strong>Objective: </strong>The aim of the study is to evaluate the effectiveness of pulmonary rehabilitation programs and other rehabilitation interventions in adults with asthma.</p><p><strong>Design: </strong>This is a systematic review and meta-analysis.</p><p><strong>Results: </strong>MEDLINE (PubMed), Embase, Cumulative Index to Nursing & Allied Health Literature, and CENTRAL were searched from inception to 31 May 2023. PROSPERO registration number: CRD42022331440. Thirty-six randomized controlled trials were analyzed, and only 26 were pooled in the meta-analysis because of the heterogeneity of comparisons and outcomes across the studies. Pulmonary rehabilitation, compared with education associated with breathing exercises, may result in little to no difference in the Asthma Quality of Life Questionnaire (mean difference 0.01 score, 95% confidence interval = -0.48 to 0.50, 163 participants, three studies, low certainty).</p><p><strong>Conclusions: </strong>Our findings show that pulmonary rehabilitation, compared with education associated with breathing exercises, may result in little to no difference in the impact of asthma on health-related quality of life. Overall, the certainty of evidence was low or very low preventing any firm conclusion on the effects of single or combined rehabilitation interventions.</p>","PeriodicalId":7850,"journal":{"name":"American Journal of Physical Medicine & Rehabilitation","volume":" ","pages":"e28-e36"},"PeriodicalIF":2.2,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141490570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-03-01Epub Date: 2024-12-12DOI: 10.1097/PHM.0000000000002689
Cumhur Deniz Davulcu
{"title":"Letter to the Editor: Relationship of Body Mass Index on Patient-Reported Outcomes After Platelet-Rich Plasma Versus Microfragmented Adipose Tissue for Knee Osteoarthritis A Secondary Analysis of a Randomized Controlled Trial.","authors":"Cumhur Deniz Davulcu","doi":"10.1097/PHM.0000000000002689","DOIUrl":"10.1097/PHM.0000000000002689","url":null,"abstract":"","PeriodicalId":7850,"journal":{"name":"American Journal of Physical Medicine & Rehabilitation","volume":" ","pages":"e47"},"PeriodicalIF":2.2,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142942833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-03-01Epub Date: 2024-08-16DOI: 10.1097/PHM.0000000000002609
Kristina Barber, Andrea Nikolis, Megan Machek, Venu Akuthota, Nathan Odom
Abstract: With increasing use of golf carts and low speed vehicles for recreational, work-related, and commuting purposes, the number of related injuries is also on the rise. The body of literature describing these injuries is informative but limited. From this scoping review, we found that low speed vehicle-related injuries preferentially affect children, older adults, and males. Common mechanisms of injury include ejection and collision. Associated alcohol consumption is common and typically related to increasing severity of injury. Various injuries may result from low speed vehicles as described in the review, including soft tissue injuries, orthopedic injuries, and traumatic brain injury. Description of trends and classifications of injury will hopefully improve reporting and ability to make recommendations on safe use and regulation.
{"title":"Traumatic Injuries From Low Speed Vehicles and Golf Carts: A Scoping Review.","authors":"Kristina Barber, Andrea Nikolis, Megan Machek, Venu Akuthota, Nathan Odom","doi":"10.1097/PHM.0000000000002609","DOIUrl":"10.1097/PHM.0000000000002609","url":null,"abstract":"<p><strong>Abstract: </strong>With increasing use of golf carts and low speed vehicles for recreational, work-related, and commuting purposes, the number of related injuries is also on the rise. The body of literature describing these injuries is informative but limited. From this scoping review, we found that low speed vehicle-related injuries preferentially affect children, older adults, and males. Common mechanisms of injury include ejection and collision. Associated alcohol consumption is common and typically related to increasing severity of injury. Various injuries may result from low speed vehicles as described in the review, including soft tissue injuries, orthopedic injuries, and traumatic brain injury. Description of trends and classifications of injury will hopefully improve reporting and ability to make recommendations on safe use and regulation.</p>","PeriodicalId":7850,"journal":{"name":"American Journal of Physical Medicine & Rehabilitation","volume":" ","pages":"286-290"},"PeriodicalIF":2.2,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142008105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: Chronic low back pain affects nociceptive responses in the cerebellum, which leads to increased pain perception and sensorimotor control dysfunction. This study aimed to investigate altered functional connectivity in the anterior and posterior lobes of the cerebellum during chronic low back pain.
Design: Twenty patients with chronic low back pain and 18 healthy participants underwent 3.0 T resting-state functional magnetic resonance imaging. The bilateral lobule V of the anterior cerebellum and Crus I of the posterior cerebellum were selected as the region of interest for identifying the corresponding networks.
Results: The left lobule V had a greater intrinsic connectivity with the left insular cortex, left orbitofrontal cortex, and bilateral medial prefrontal cortex in patients with chronic low back pain. In contrast, the right lobule V and bilateral Crus I had a significantly decreased connectivity with the contralateral multimodal cerebral networks, including the default mode network, salience network, and emotional network.
Conclusions: The cerebellum had mechanistic implications in pain-related changes, which are involved in motor control, cognition, and emotion processing. These findings provide a novel perspective on the role of functional subregions in chronic low back pain, which add to the growing body of evidence that the cerebellum can be a potential target for noninvasive brain stimulation for chronic pain treatment.
目的慢性腰背痛(cLBP)会影响小脑的痛觉反应,从而导致痛觉增强和感觉运动控制功能障碍。本研究旨在调查慢性腰背痛时小脑前叶和后叶功能连接的改变:20名cLBP患者和18名健康参与者接受了3.0 T静息态功能磁共振成像。选择双侧小脑前叶 V 和小脑后叶 Crus I 作为研究区域,以确定相应的网络:结果:在cLBP患者中,左侧小脑小叶V与左侧岛叶皮层、左侧眶额皮层和双侧内侧前额叶皮层有更多的内在联系。相比之下,右侧小叶V和双侧Crus I与对侧多模大脑网络(包括默认模式网络、显著性网络和情绪网络)的连接性明显降低:结论:小脑在与疼痛相关的变化中具有机理意义,这些变化涉及运动控制、认知和情绪处理。这些发现为功能亚区在 cLBP 中的作用提供了一个新的视角,使越来越多的证据表明小脑可以成为无创脑部刺激治疗慢性疼痛的潜在靶点。
{"title":"Resting-State Functional Connectivity of the Cerebellum in Patients With Chronic Low Back Pain.","authors":"Shanshan Zhang, Guifang Zhang, Shanshan Bao, Jiaqi Tan, Rongxing He, Hongjiang Wang, Shenglan Yan, Chuhuai Wang","doi":"10.1097/PHM.0000000000002583","DOIUrl":"10.1097/PHM.0000000000002583","url":null,"abstract":"<p><strong>Objective: </strong>Chronic low back pain affects nociceptive responses in the cerebellum, which leads to increased pain perception and sensorimotor control dysfunction. This study aimed to investigate altered functional connectivity in the anterior and posterior lobes of the cerebellum during chronic low back pain.</p><p><strong>Design: </strong>Twenty patients with chronic low back pain and 18 healthy participants underwent 3.0 T resting-state functional magnetic resonance imaging. The bilateral lobule V of the anterior cerebellum and Crus I of the posterior cerebellum were selected as the region of interest for identifying the corresponding networks.</p><p><strong>Results: </strong>The left lobule V had a greater intrinsic connectivity with the left insular cortex, left orbitofrontal cortex, and bilateral medial prefrontal cortex in patients with chronic low back pain. In contrast, the right lobule V and bilateral Crus I had a significantly decreased connectivity with the contralateral multimodal cerebral networks, including the default mode network, salience network, and emotional network.</p><p><strong>Conclusions: </strong>The cerebellum had mechanistic implications in pain-related changes, which are involved in motor control, cognition, and emotion processing. These findings provide a novel perspective on the role of functional subregions in chronic low back pain, which add to the growing body of evidence that the cerebellum can be a potential target for noninvasive brain stimulation for chronic pain treatment.</p>","PeriodicalId":7850,"journal":{"name":"American Journal of Physical Medicine & Rehabilitation","volume":" ","pages":"257-263"},"PeriodicalIF":2.2,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141787083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}