Pub Date : 2021-01-22DOI: 10.11648/J.AJBLS.20210901.14
H. Mahmood, T. Shah, Sohail Rasool, Ammara Waqar, Zia-ul-Miraj, Z. Maken, Awais Gohar, A. Rauf
Introduction: Hyperemesis Gravidarum (HG) is a common early pregnancy syndrome that usually occurs around 6 weeks of pregnancy. The patient may cause dehydration, electrolyte metabolism disorders and abnormal fat metabolism, causing increased risk of pregnancy-induced. Objective: The effects of vitamin B and acupressure application combined with psychological adjuvant therapy on vomiting symptoms and mental health in pregnant women with severe vomiting. Methods: Study Type: Randomized Control Trial Duration of Study: Twelve Months from January 2019 to December 2019 Sampling Technique: The data has been collected from the subject index coming to the gynecology OPD of Gulab Devi Teaching Hospital, Lahore, Pakistan. Control group: aged 20 to 37 years, with an average of (26.12±2.44) years; 8 to 17 weeks of gestation, with an average of (9.18±1.77) weeks. Sample Selection Inclusion Criteria: All persons who have 1) meet the diagnostic criteria for HG; 2) 20 to 40 years of age; 3) both signed informed consent. Exclusion Criteria: vomiting caused by medical diseases such as hydatidiform mole, gastrointestinal disease, viral hepatitis, cholecystitis. This study was approved by the Medical Ethics Committee of Gulab Devi Teaching hospital. Pregnant women who were enrolled were divided into control group and experimental group according to the random number table method, with 48 cases in each group. Study Tools: Questionnaire and Interview Sample size (n)=96. Results: After 7 days of treatment the effective percentage rate in the experimental group was higher as compare to the control group in terms of clinical efficacy, SAS and SDS scores, antiemetic and hospitalization time and cost was much lower and within limits in the experimental group as compare to control group. Discussion: In addition to physiological treatment such as fluid replacement, psychological treatment should not be ignored. Conclusion: vitamin B6 and acupressure application combined with psychological adjunctive treatment of HG had a significant effect and could significantly relieve pregnant women Anxiety, depression and promote the recovery of pregnant women.
{"title":"Effect of Vitamin B6 and Acupressure on Vomiting Symptoms in Pregnant Women with Hyperemesis Gravidarum","authors":"H. Mahmood, T. Shah, Sohail Rasool, Ammara Waqar, Zia-ul-Miraj, Z. Maken, Awais Gohar, A. Rauf","doi":"10.11648/J.AJBLS.20210901.14","DOIUrl":"https://doi.org/10.11648/J.AJBLS.20210901.14","url":null,"abstract":"Introduction: Hyperemesis Gravidarum (HG) is a common early pregnancy syndrome that usually occurs around 6 weeks of pregnancy. The patient may cause dehydration, electrolyte metabolism disorders and abnormal fat metabolism, causing increased risk of pregnancy-induced. Objective: The effects of vitamin B and acupressure application combined with psychological adjuvant therapy on vomiting symptoms and mental health in pregnant women with severe vomiting. Methods: Study Type: Randomized Control Trial Duration of Study: Twelve Months from January 2019 to December 2019 Sampling Technique: The data has been collected from the subject index coming to the gynecology OPD of Gulab Devi Teaching Hospital, Lahore, Pakistan. Control group: aged 20 to 37 years, with an average of (26.12±2.44) years; 8 to 17 weeks of gestation, with an average of (9.18±1.77) weeks. Sample Selection Inclusion Criteria: All persons who have 1) meet the diagnostic criteria for HG; 2) 20 to 40 years of age; 3) both signed informed consent. Exclusion Criteria: vomiting caused by medical diseases such as hydatidiform mole, gastrointestinal disease, viral hepatitis, cholecystitis. This study was approved by the Medical Ethics Committee of Gulab Devi Teaching hospital. Pregnant women who were enrolled were divided into control group and experimental group according to the random number table method, with 48 cases in each group. Study Tools: Questionnaire and Interview Sample size (n)=96. Results: After 7 days of treatment the effective percentage rate in the experimental group was higher as compare to the control group in terms of clinical efficacy, SAS and SDS scores, antiemetic and hospitalization time and cost was much lower and within limits in the experimental group as compare to control group. Discussion: In addition to physiological treatment such as fluid replacement, psychological treatment should not be ignored. Conclusion: vitamin B6 and acupressure application combined with psychological adjunctive treatment of HG had a significant effect and could significantly relieve pregnant women Anxiety, depression and promote the recovery of pregnant women.","PeriodicalId":7857,"journal":{"name":"American Journal of Biomedical and Life Sciences","volume":"25 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74011244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-22DOI: 10.11648/J.AJBLS.20210901.13
Jesus’ Christus, M. Madson
COVID-19 is pandemic. Neuraminidase ịs central to both infection from the virus and is involved in the cell's endothelial cell rolling, as an example. Inhibition of glycosidases are known to include anhydro ald(ket)itols. An L-1,5-anhydro fucitol substituted by a derivatized (diħydrido) sulfo hydrate has been synthesized from bovine thyroglobulin N-linked oligosaccharide dipeptide. Also, 2,5-anhydro 1,6 di-(hydrido) di-phospho diħydrate mannitol (glucitol) has been prepared. Both include a treatment with NaBH4 in NH4OH. Here evidence is presented on 2,6-anhydro N-acetamido neuraminitol under similar reaction conditions using Kappa casein and bovine submaxilary mucin (bsm). It is hoped to use these reaction conditions and apply it to bovine milk. It may be possible to synthesize 2,6-anhydro N-acetamido neuraminitol in two steps from bovine milk. Then treatment costs can be afforded by those who are financially compromised. Conditions used are 8 hours at ambient temperature in a capped or un-capped reaction vial. These glycoproteins were treated with PNGase-F which could contain peptidase activity that acts in appreciable quantities in the large excesses of PNGase-F used here. Then the effluent from an NH4+ form cation exchange cartridge to which it was bound, after H2O wash, were eluted with NH4OH and partially evaporated to remove excess base. The reaction products were stored frozen prior to analysis by a single quadrupole mass spectrometer, AQA, or a triple quadrupole mass spectrometer, API 2000. Fetuin was treated in the same manner but was used only as a standard and not included as sc a starting material. Hope is in the transfer of these protocols to the preparation pf 2,6-anhydro N-acetamido neuraminitol. It may act as a two-pronged attack on COVID-19 infection. Previous work suggests that the purification of 2,6-anhydro N-acetamido neuraminitol is not trivial.
{"title":"Sialylated Carbohydrates as Inhinitors of Coronavirus Infection","authors":"Jesus’ Christus, M. Madson","doi":"10.11648/J.AJBLS.20210901.13","DOIUrl":"https://doi.org/10.11648/J.AJBLS.20210901.13","url":null,"abstract":"COVID-19 is pandemic. Neuraminidase ịs central to both infection from the virus and is involved in the cell's endothelial cell rolling, as an example. Inhibition of glycosidases are known to include anhydro ald(ket)itols. An L-1,5-anhydro fucitol substituted by a derivatized (diħydrido) sulfo hydrate has been synthesized from bovine thyroglobulin N-linked oligosaccharide dipeptide. Also, 2,5-anhydro 1,6 di-(hydrido) di-phospho diħydrate mannitol (glucitol) has been prepared. Both include a treatment with NaBH4 in NH4OH. Here evidence is presented on 2,6-anhydro N-acetamido neuraminitol under similar reaction conditions using Kappa casein and bovine submaxilary mucin (bsm). It is hoped to use these reaction conditions and apply it to bovine milk. It may be possible to synthesize 2,6-anhydro N-acetamido neuraminitol in two steps from bovine milk. Then treatment costs can be afforded by those who are financially compromised. Conditions used are 8 hours at ambient temperature in a capped or un-capped reaction vial. These glycoproteins were treated with PNGase-F which could contain peptidase activity that acts in appreciable quantities in the large excesses of PNGase-F used here. Then the effluent from an NH4+ form cation exchange cartridge to which it was bound, after H2O wash, were eluted with NH4OH and partially evaporated to remove excess base. The reaction products were stored frozen prior to analysis by a single quadrupole mass spectrometer, AQA, or a triple quadrupole mass spectrometer, API 2000. Fetuin was treated in the same manner but was used only as a standard and not included as sc a starting material. Hope is in the transfer of these protocols to the preparation pf 2,6-anhydro N-acetamido neuraminitol. It may act as a two-pronged attack on COVID-19 infection. Previous work suggests that the purification of 2,6-anhydro N-acetamido neuraminitol is not trivial.","PeriodicalId":7857,"journal":{"name":"American Journal of Biomedical and Life Sciences","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89005623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-22DOI: 10.11648/J.AJBLS.20210901.15
H. Mahmood, T. Shah, Sohail Rasool, Ammara Waqar, M. Zia-ul-Miraj, Awais Gohar, A. Rauf
Introduction: In Pakistan, a wave of coronavirus has started in February which was first reported in Wahun City China. Abnormal calcium blood level is considered one of the important and common electrolyte disturbances in patients with severe infection. The effect of blood calcium level on the severity of COVID-19 and the possible immune regulation mechanism is considered to be an important factor related to severity of disease. Aim of the Study: To find out the correlation of blood calcium levels and related risk factors of patients suffering from COVID-19 and provide a basis for early intervention in patients with relevant clinical characteristics and further reduce the incidence of critical illness and mortality in COVID-19 patients. Method: 180 COVID-19 patients were admitted to Gulab Devi Teaching Hospital, Lahore between February to July 2020. Subject index were tested on real-time fluorescent RT-PCR test. On the basis of the result of RT-PCR, they were divided into two groups according to clinical symptoms as mild (control/placebo group) and critical (experimental group). The patient with the mild symptom were included in the placebo group, whereas patient with the severe symptoms were included in the experimental group. Exclusion criteria: The patients who do not show the detection level of viral infection with the RT-PCR are excluded from the study. Results: The comparison has been carried out between the placebo group and the experimental group on the basis of various parameters. The patients serum calcium level was tested and the value for hypocalcemia was declared as per universal recommendation which is < 2.13mmol/L. According to the corrected serum total calcium level, COVID-19 patients can be divided into hypocalcemia group and normal blood calcium group. The result showed that hypocalcemia and immune dysfunction was found high in experimental group as compare to control group which shows a strong correlation between hypocalcemia and COVID-19 disease. Conclusion: It has been concluded from the study that patients with COVID-19 have obvious hypocalcemia and immune dysfunction, especially in experimental group patients. In this study, it is easy to be combined with multiple infections caused by pathogenic bacteria under certain conditions. Close monitoring of blood calcium levels can predict the severity of the disease more effectively.
{"title":"Relationship of Hypocalciamia and Severity of Disease in COVID-19 Patients in Lahore Pakistan","authors":"H. Mahmood, T. Shah, Sohail Rasool, Ammara Waqar, M. Zia-ul-Miraj, Awais Gohar, A. Rauf","doi":"10.11648/J.AJBLS.20210901.15","DOIUrl":"https://doi.org/10.11648/J.AJBLS.20210901.15","url":null,"abstract":"Introduction: In Pakistan, a wave of coronavirus has started in February which was first reported in Wahun City China. Abnormal calcium blood level is considered one of the important and common electrolyte disturbances in patients with severe infection. The effect of blood calcium level on the severity of COVID-19 and the possible immune regulation mechanism is considered to be an important factor related to severity of disease. Aim of the Study: To find out the correlation of blood calcium levels and related risk factors of patients suffering from COVID-19 and provide a basis for early intervention in patients with relevant clinical characteristics and further reduce the incidence of critical illness and mortality in COVID-19 patients. Method: 180 COVID-19 patients were admitted to Gulab Devi Teaching Hospital, Lahore between February to July 2020. Subject index were tested on real-time fluorescent RT-PCR test. On the basis of the result of RT-PCR, they were divided into two groups according to clinical symptoms as mild (control/placebo group) and critical (experimental group). The patient with the mild symptom were included in the placebo group, whereas patient with the severe symptoms were included in the experimental group. Exclusion criteria: The patients who do not show the detection level of viral infection with the RT-PCR are excluded from the study. Results: The comparison has been carried out between the placebo group and the experimental group on the basis of various parameters. The patients serum calcium level was tested and the value for hypocalcemia was declared as per universal recommendation which is < 2.13mmol/L. According to the corrected serum total calcium level, COVID-19 patients can be divided into hypocalcemia group and normal blood calcium group. The result showed that hypocalcemia and immune dysfunction was found high in experimental group as compare to control group which shows a strong correlation between hypocalcemia and COVID-19 disease. Conclusion: It has been concluded from the study that patients with COVID-19 have obvious hypocalcemia and immune dysfunction, especially in experimental group patients. In this study, it is easy to be combined with multiple infections caused by pathogenic bacteria under certain conditions. Close monitoring of blood calcium levels can predict the severity of the disease more effectively.","PeriodicalId":7857,"journal":{"name":"American Journal of Biomedical and Life Sciences","volume":"1 1","pages":"36"},"PeriodicalIF":0.0,"publicationDate":"2021-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83188147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-18DOI: 10.11648/J.AJBLS.20210901.12
L. Hongyan, Ma Jinqun, Wang Cuicui, Liu Jianfeng, Chen Yunxia, L. Chunyan, Hou Zhenjiang
Objective: In order to discuss the correlation between thyroid function stratification and autoantibody titer in HT patients under different iodine nutritional status. Methods: The serum TH, antibody and urinary iodine levels were measured by the electrochemical immune-luminescent apparatus and iodine-catalyzed arsenic-cerium method in 100 HT patients (HT-A, HT-B, HT-C) with different thyroid functions and 60 healthy subjects. Results: The urinary iodine level of HT patients from HT-A increased in turn along with the progression of the disease, while the levels of FT3, FT4, TT3, TT4 decreased gradually and the levels of TSH and thyroid autoantibodies increased gradually. The urinary iodine level of HT-C group was negatively correlated with the serum FT3, FT4, TT3 and TT4 (P<0.05), while the urinary iodine level of HT-B group was negatively correlated with the serum FT3 and TT4 (P<0.05), and positively correlated with TSH (P<0.05). Along with the progression of HT disease, the levels of serum TPOAb and TGAb increased successively, and there were significant differences among each group (P<0.01). The serum TSH level of high TPOAb group and high TgAb group were respectively higher than those of low TPOAb group, low TgAb group and the control group, the levels of FT3 and FT4 were respectively lower than the low TPOAb group and low TGAb group, but there were no statistically significant on the differences between the FT3 of low TgAb and the levels of T3 and T4 of the control group, high TPOAb group, high TGAb group, low TPOAb group and low TGAb group. Conclusions: Under different iodine nutritional status, if the TH and autoantibody levels of HT patients with different thyroid functions changed correspondingly, it could indicate that the iodine nutritional status is involved in the occurrence and development process of HT of different thyroid functions and antibody levels, and plays an important role in it.
{"title":"Correlation Analysis Between Thyroid Function and Autoantibodies in Hashimoto Thyroiditis Patients with Different Iodine Nutritional Status","authors":"L. Hongyan, Ma Jinqun, Wang Cuicui, Liu Jianfeng, Chen Yunxia, L. Chunyan, Hou Zhenjiang","doi":"10.11648/J.AJBLS.20210901.12","DOIUrl":"https://doi.org/10.11648/J.AJBLS.20210901.12","url":null,"abstract":"Objective: In order to discuss the correlation between thyroid function stratification and autoantibody titer in HT patients under different iodine nutritional status. Methods: The serum TH, antibody and urinary iodine levels were measured by the electrochemical immune-luminescent apparatus and iodine-catalyzed arsenic-cerium method in 100 HT patients (HT-A, HT-B, HT-C) with different thyroid functions and 60 healthy subjects. Results: The urinary iodine level of HT patients from HT-A increased in turn along with the progression of the disease, while the levels of FT3, FT4, TT3, TT4 decreased gradually and the levels of TSH and thyroid autoantibodies increased gradually. The urinary iodine level of HT-C group was negatively correlated with the serum FT3, FT4, TT3 and TT4 (P<0.05), while the urinary iodine level of HT-B group was negatively correlated with the serum FT3 and TT4 (P<0.05), and positively correlated with TSH (P<0.05). Along with the progression of HT disease, the levels of serum TPOAb and TGAb increased successively, and there were significant differences among each group (P<0.01). The serum TSH level of high TPOAb group and high TgAb group were respectively higher than those of low TPOAb group, low TgAb group and the control group, the levels of FT3 and FT4 were respectively lower than the low TPOAb group and low TGAb group, but there were no statistically significant on the differences between the FT3 of low TgAb and the levels of T3 and T4 of the control group, high TPOAb group, high TGAb group, low TPOAb group and low TGAb group. Conclusions: Under different iodine nutritional status, if the TH and autoantibody levels of HT patients with different thyroid functions changed correspondingly, it could indicate that the iodine nutritional status is involved in the occurrence and development process of HT of different thyroid functions and antibody levels, and plays an important role in it.","PeriodicalId":7857,"journal":{"name":"American Journal of Biomedical and Life Sciences","volume":"99 2 1","pages":"10"},"PeriodicalIF":0.0,"publicationDate":"2021-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73418932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-18DOI: 10.11648/J.AJBLS.20210901.11
M. Uddin, Safiullah
Now-a-days, patients’ voice regarding the delivery of health care services is a burning question in the developing countries. It is thought that patients’ perceptions towards health services are mostly ignored in these countries by the health service providers. This study, therefore, seeks the service quality factors which are essential to the patients. A field survey was made in this purpose on the heart disease patients in Dhaka city as this disease is very common in Bangladesh. SERVQUAL modeling approach and principal component analysis were considered to make evaluation over hospital facilities and found, overall, dissatisfaction of the patients. The SERVQUAL model is used to assess patients’ expectations and perceptions regarding service quality in hospitals. Both expectations and perceptions are measured using a 5-point scale to rate their level of agreement or disagreement (1: strongly disagree and 5: strongly agree), on which the higher numbers indicate higher level of expectation or perceptions. Perceptions are based on the actual service they receive in hospitals are based on experiences and information received about hospital stuffs, doctors or overall hospital maintenance system. Service quality scores are obtained from the difference between the expectation and perception scores which range from -4 to +4 (-4: very dissatisfied, +4: very satisfied). The quality score measures the service gap, that is, the degree to which the expectations excels perceptions. Binary logistic regression analysis was used to find out significant covariates for occurring heart disease. Also, a Poisson regression model was performed for detecting potential covariates that affect number of hospital visit (s) per year of the heart disease patients. The study found ultimate dissatisfaction of the patients which brings the thought that a powerful managerial orientation might be launched in the hospitals to ensure quality services.
{"title":"Satisfaction on Hospital Services in Dhaka Among Heart Disease Patients: A SERVQUAL Modeling Approach","authors":"M. Uddin, Safiullah","doi":"10.11648/J.AJBLS.20210901.11","DOIUrl":"https://doi.org/10.11648/J.AJBLS.20210901.11","url":null,"abstract":"Now-a-days, patients’ voice regarding the delivery of health care services is a burning question in the developing countries. It is thought that patients’ perceptions towards health services are mostly ignored in these countries by the health service providers. This study, therefore, seeks the service quality factors which are essential to the patients. A field survey was made in this purpose on the heart disease patients in Dhaka city as this disease is very common in Bangladesh. SERVQUAL modeling approach and principal component analysis were considered to make evaluation over hospital facilities and found, overall, dissatisfaction of the patients. The SERVQUAL model is used to assess patients’ expectations and perceptions regarding service quality in hospitals. Both expectations and perceptions are measured using a 5-point scale to rate their level of agreement or disagreement (1: strongly disagree and 5: strongly agree), on which the higher numbers indicate higher level of expectation or perceptions. Perceptions are based on the actual service they receive in hospitals are based on experiences and information received about hospital stuffs, doctors or overall hospital maintenance system. Service quality scores are obtained from the difference between the expectation and perception scores which range from -4 to +4 (-4: very dissatisfied, +4: very satisfied). The quality score measures the service gap, that is, the degree to which the expectations excels perceptions. Binary logistic regression analysis was used to find out significant covariates for occurring heart disease. Also, a Poisson regression model was performed for detecting potential covariates that affect number of hospital visit (s) per year of the heart disease patients. The study found ultimate dissatisfaction of the patients which brings the thought that a powerful managerial orientation might be launched in the hospitals to ensure quality services.","PeriodicalId":7857,"journal":{"name":"American Journal of Biomedical and Life Sciences","volume":"6 1","pages":"1"},"PeriodicalIF":0.0,"publicationDate":"2021-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74009979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.11648/j.ajbls.20210905.20
Fu Xianzhao, Jiang Xiaofeng, Chen Jiajun, Cen Qianli, Li Yuegui, Qiu Haixian
: Objective to investigate the effect of Huoxue Jiedu Jiangtang Recipe (HJJR) on cardiac remodeling and function prognosis in diabetic patients complicated with coronary heart disease (CHD) after percutaneous coronary intervention (PCI), and to explore its possible mechanism. Methods 92 diabetic patients with CHD who had received PCI therapy, were equally randomized into the treatment group (46) and the control group (46) from January 2016 to August 2016. The control group were given standardized western medicine, while treatment group received HJJR besides standardized treatment. The treating course were 2 months. Before and after treatment, the left ventricular morphology index [left ventricular end diastolic diameter (LVEDD), left ventricular end systolic diameter (LVESD), left ventricular posterior wall thickness (LVPWT), left ventricular end-diastolic ventricular septal thickness (LVEST)] and the cardiac function data [stroke volume (SV), left ventricular fractional shortening (FS), the cardiac index (CI), cardiac output (CO), maximum blood flow velocity of early diastolic/ atrium late diastolic (E/A), left ventricle ejection fraction (EF)] were detected with echocardiography. The serum levels of C-reactive protein (CRP), tumor necrosis factor-a (TNF-α), interleukin-6 (IL-6) and Angiotensin II (Ang II) were tested with enzyme linked immunosorbent assay (ELISA), and the clinical efficacy and 5-year survival rate were evaluated. Results The total clinical effective rate and 5-year survival ratio in treatment group were higher than those in control group (P<0.05). Serum inflammatory mediators (CRP, IL-6, TNF-α) and Ang II decreased more than that in the control group (all P<0.05); And in treatment group, the left ventricular morphology index (LVESD, LVEDD) decreased more than that in the control group, while the cardiac function indexes (∆ FS, CO, CI, SV, LVEF, E/A) were increased more in treatment group. Conclusion HJJR can hold back the deterioration of heart restructure, improve heart function, ameliorate prognosis and prolong living in diabetic CHD after PCI, and its partial therapeutic effects might come from its reducing the level of Ang II and anti-inflammatory function.
{"title":"Double Regulation of Tonifying-Detoxifing on Elderly Diabetic Coronary Heart Disease After PCI","authors":"Fu Xianzhao, Jiang Xiaofeng, Chen Jiajun, Cen Qianli, Li Yuegui, Qiu Haixian","doi":"10.11648/j.ajbls.20210905.20","DOIUrl":"https://doi.org/10.11648/j.ajbls.20210905.20","url":null,"abstract":": Objective to investigate the effect of Huoxue Jiedu Jiangtang Recipe (HJJR) on cardiac remodeling and function prognosis in diabetic patients complicated with coronary heart disease (CHD) after percutaneous coronary intervention (PCI), and to explore its possible mechanism. Methods 92 diabetic patients with CHD who had received PCI therapy, were equally randomized into the treatment group (46) and the control group (46) from January 2016 to August 2016. The control group were given standardized western medicine, while treatment group received HJJR besides standardized treatment. The treating course were 2 months. Before and after treatment, the left ventricular morphology index [left ventricular end diastolic diameter (LVEDD), left ventricular end systolic diameter (LVESD), left ventricular posterior wall thickness (LVPWT), left ventricular end-diastolic ventricular septal thickness (LVEST)] and the cardiac function data [stroke volume (SV), left ventricular fractional shortening (FS), the cardiac index (CI), cardiac output (CO), maximum blood flow velocity of early diastolic/ atrium late diastolic (E/A), left ventricle ejection fraction (EF)] were detected with echocardiography. The serum levels of C-reactive protein (CRP), tumor necrosis factor-a (TNF-α), interleukin-6 (IL-6) and Angiotensin II (Ang II) were tested with enzyme linked immunosorbent assay (ELISA), and the clinical efficacy and 5-year survival rate were evaluated. Results The total clinical effective rate and 5-year survival ratio in treatment group were higher than those in control group (P<0.05). Serum inflammatory mediators (CRP, IL-6, TNF-α) and Ang II decreased more than that in the control group (all P<0.05); And in treatment group, the left ventricular morphology index (LVESD, LVEDD) decreased more than that in the control group, while the cardiac function indexes (∆ FS, CO, CI, SV, LVEF, E/A) were increased more in treatment group. Conclusion HJJR can hold back the deterioration of heart restructure, improve heart function, ameliorate prognosis and prolong living in diabetic CHD after PCI, and its partial therapeutic effects might come from its reducing the level of Ang II and anti-inflammatory function.","PeriodicalId":7857,"journal":{"name":"American Journal of Biomedical and Life Sciences","volume":"70 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73334687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.11648/j.ajbls.20210906.18
Salifou I. Traore, Ousmane Dembélé, Soumaila A. Traore, Aly B. Diallo, Malla Sylla, A. Maiga, M. Kante, L. Touré, B. Traoré, M. Diassana, T. Traoré, A. Dolo, S. Ouattara
{"title":"Epidemiological, Therapeutics Aspects and Socioeconomics Consequences of Urogenital Fistula","authors":"Salifou I. Traore, Ousmane Dembélé, Soumaila A. Traore, Aly B. Diallo, Malla Sylla, A. Maiga, M. Kante, L. Touré, B. Traoré, M. Diassana, T. Traoré, A. Dolo, S. Ouattara","doi":"10.11648/j.ajbls.20210906.18","DOIUrl":"https://doi.org/10.11648/j.ajbls.20210906.18","url":null,"abstract":"","PeriodicalId":7857,"journal":{"name":"American Journal of Biomedical and Life Sciences","volume":"92 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80496474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.11648/J.AJBLS.20210902.12
Y. Gurmu, Gada Edea, Eniyewu Molla, Dirriba Tari, Elifitu Lamesa, Elsa Belay
Background: Ethiopian was able to expand the immunization service by introducing new vaccines into the country routine immunization program that increased the number of antigens from 10 to 12. Expanded Program on Immunization (EPI) is one of the key programs in World Health Organization (WHO) Ethiopia under the Maternal, Child Health and Nutrition (MCHN). Compliance to vaccination may be influenced by understanding of the community towards the service. Objective: To assess the knowledge, Attitude and practice of mothers towards vaccination of their infants in Shashemene referral Hospital west Arsi, Zone Oromia Regional state, South-Ethiopia, 2018. Method: Institutional based cross-sectional study design was conducted in shashemene Referral Hospital from February to April 10, 2018. Face to face structured Interview questionnaire was used by systematic sampling techniques. Data collection was start from March 01 to 30, 2018 G. C and after reviewing, data was analyzing with SPSS software version 20. Result: A total of 228 mothers were participated on this study, giving the response rate of 98.1%. From the total respondents (52.3%) of mothers have good knowledge and (42.3%) of them had good practices of services utilization of vaccination for their infants. Conclusion: This study showed that 52.3%, 67.7%, 42.3% of study participant had good knowledge, attitude, and practice towards immunization of infants respectively. Educational interventions are required to improve parents’ knowledge, attitude, and practice.
{"title":"Knowledge, Attitude and Practice of Mothers Toward Immunization of Their Infants in Shashemene Referral Hospital, West Arsi Zone, Oromia Regional State, Ethiopia","authors":"Y. Gurmu, Gada Edea, Eniyewu Molla, Dirriba Tari, Elifitu Lamesa, Elsa Belay","doi":"10.11648/J.AJBLS.20210902.12","DOIUrl":"https://doi.org/10.11648/J.AJBLS.20210902.12","url":null,"abstract":"Background: Ethiopian was able to expand the immunization service by introducing new vaccines into the country routine immunization program that increased the number of antigens from 10 to 12. Expanded Program on Immunization (EPI) is one of the key programs in World Health Organization (WHO) Ethiopia under the Maternal, Child Health and Nutrition (MCHN). Compliance to vaccination may be influenced by understanding of the community towards the service. Objective: To assess the knowledge, Attitude and practice of mothers towards vaccination of their infants in Shashemene referral Hospital west Arsi, Zone Oromia Regional state, South-Ethiopia, 2018. Method: Institutional based cross-sectional study design was conducted in shashemene Referral Hospital from February to April 10, 2018. Face to face structured Interview questionnaire was used by systematic sampling techniques. Data collection was start from March 01 to 30, 2018 G. C and after reviewing, data was analyzing with SPSS software version 20. Result: A total of 228 mothers were participated on this study, giving the response rate of 98.1%. From the total respondents (52.3%) of mothers have good knowledge and (42.3%) of them had good practices of services utilization of vaccination for their infants. Conclusion: This study showed that 52.3%, 67.7%, 42.3% of study participant had good knowledge, attitude, and practice towards immunization of infants respectively. Educational interventions are required to improve parents’ knowledge, attitude, and practice.","PeriodicalId":7857,"journal":{"name":"American Journal of Biomedical and Life Sciences","volume":"52 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81772868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.11648/j.ajbls.20210906.15
G. Madonia, U. Madonia
{"title":"Beware of Dog: Practical Consideration in Asthmatic Patients with Poor Perception of Respiratory Symptoms","authors":"G. Madonia, U. Madonia","doi":"10.11648/j.ajbls.20210906.15","DOIUrl":"https://doi.org/10.11648/j.ajbls.20210906.15","url":null,"abstract":"","PeriodicalId":7857,"journal":{"name":"American Journal of Biomedical and Life Sciences","volume":"33 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91109337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.11648/j.ajbls.20210904.15
Maurício Aurelio Gomes Heleno, Edda E Newball-Noriega, S. Huancahuire-Vega, R. S. F. Júnior, B. Barraviera
: Snake venoms are important sources of complex substances with a variety of pharmacological activities. Among them serine proteinases (SVSPs) have important effects on the hemostatic system influencing the hemodynamic of human or animal blood. Bothrops genus-snake venoms are rich in the thrombin-like enzyme, a type of SVSPs, with great interest to produce medicine. Therefore, the aim of this work was to describe a rapid, only two-step chromatographic-procedure developed to perform a faster purification of SVSPs from Bothrops alternatus and Bothrops moojeni venoms. As a result, two groups of serine proteinases respectively BaIII-4 - 8 and BmIII-2 - 5, were isolated and their molecular masses estimated by mass spectrometry and SDS-PAGE under denaturing conditions. The SVTLEs isolated from B. alternatus (BaIII-3 - 8) and B. moojeni (BmIII-2 - 5) fractions displayed apparent molecular mass around 30-40 kDa which closely relates to SVTLEs from other Bothrops species, as well their amino acid partial sequence triptych ions. Analysis of the alignment of the amino acid residue sequences of the N-terminal of the isolated proteins revealed a high level of identity with other SVTLEs. These enzymes coagulated plasma and showed fibrinogenolytic activity in blood. These SVTLEs isolated can be considered α-fibrinogenase mainly due to the fact that they hydrolyze the Aα chain fibrinogen. B. moojeni SVTLE showed greater activity than those from B. alternatus isolated. This new purification alternative approach developed was faster and more economical than the traditional process currently used. Faster purification and improved extraction yield can provide new insights into these enzymes including the use as a candidate molecule in the production of new drugs.
{"title":"A Novel Fast and Efficient Approach to Purify the Thrombin-like Enzyme from Two Bothrops-genus Snake Venoms","authors":"Maurício Aurelio Gomes Heleno, Edda E Newball-Noriega, S. Huancahuire-Vega, R. S. F. Júnior, B. Barraviera","doi":"10.11648/j.ajbls.20210904.15","DOIUrl":"https://doi.org/10.11648/j.ajbls.20210904.15","url":null,"abstract":": Snake venoms are important sources of complex substances with a variety of pharmacological activities. Among them serine proteinases (SVSPs) have important effects on the hemostatic system influencing the hemodynamic of human or animal blood. Bothrops genus-snake venoms are rich in the thrombin-like enzyme, a type of SVSPs, with great interest to produce medicine. Therefore, the aim of this work was to describe a rapid, only two-step chromatographic-procedure developed to perform a faster purification of SVSPs from Bothrops alternatus and Bothrops moojeni venoms. As a result, two groups of serine proteinases respectively BaIII-4 - 8 and BmIII-2 - 5, were isolated and their molecular masses estimated by mass spectrometry and SDS-PAGE under denaturing conditions. The SVTLEs isolated from B. alternatus (BaIII-3 - 8) and B. moojeni (BmIII-2 - 5) fractions displayed apparent molecular mass around 30-40 kDa which closely relates to SVTLEs from other Bothrops species, as well their amino acid partial sequence triptych ions. Analysis of the alignment of the amino acid residue sequences of the N-terminal of the isolated proteins revealed a high level of identity with other SVTLEs. These enzymes coagulated plasma and showed fibrinogenolytic activity in blood. These SVTLEs isolated can be considered α-fibrinogenase mainly due to the fact that they hydrolyze the Aα chain fibrinogen. B. moojeni SVTLE showed greater activity than those from B. alternatus isolated. This new purification alternative approach developed was faster and more economical than the traditional process currently used. Faster purification and improved extraction yield can provide new insights into these enzymes including the use as a candidate molecule in the production of new drugs.","PeriodicalId":7857,"journal":{"name":"American Journal of Biomedical and Life Sciences","volume":"20 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84466570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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