Pub Date : 2023-09-01DOI: 10.1016/j.annder.2023.03.005
E. Elzaouk, F. Bourlond, Y. Scrivener, B. Cribier
Background
Necrobiosis lipoidica (NL) is a chronic granulomatous dermatosis usually affecting the lower limbs, although less common sites have been described. Herein we report a series of cases of NL located on the elbow, with an unusual presentation and occurring after trauma or surgery.
Observations
Our series includes three men and one woman, with a mean age of 64 years. Three had undergone surgery for elbow bursitis and one had had trauma after a fall from a horse, with exposure of subcutaneous tissue prior to healing. Within 5 years, they had all developed an atrophic erythematous annular plaque with papular and telangiectatic edges, with recurrent episodes of ulceration and scarring. Repeated tests for infectious agents were negative. Histological examinations showed granulomas and necrobiosis with palisading or early-stage palisading. Partial healing was achieved in two patients after 6 months of doxycycline. Treatment with adalimumab resulted in disappearance of the ulcers at 6 months in one patient.
Discussion
Unusual sites of NL impose consideration of other types of palisading granuloma or mycobacterial infections, which we were able to rule out. Two other cases of NL of the elbow similar to ours are reported in the literature. These cases, involving multiple ulcerations over a very long period of time, probably constitute a distinct entity because of the very distinct character of these 6 cases. Tetracyclines are partially active and tumour necrosis factor alpha (TNF)-alpha inhibitors may offer an option.
{"title":"Post-traumatic ulcerated and chronic necrobiosis lipoidica of the elbow: A new entity?","authors":"E. Elzaouk, F. Bourlond, Y. Scrivener, B. Cribier","doi":"10.1016/j.annder.2023.03.005","DOIUrl":"10.1016/j.annder.2023.03.005","url":null,"abstract":"<div><h3>Background</h3><p><span><span>Necrobiosis lipoidica (NL) is a chronic </span>granulomatous </span>dermatosis usually affecting the lower limbs, although less common sites have been described. Herein we report a series of cases of NL located on the elbow, with an unusual presentation and occurring after trauma or surgery.</p></div><div><h3>Observations</h3><p><span><span>Our series includes three men and one woman, with a mean age of 64 years. Three had undergone surgery for elbow bursitis and one had had trauma after a fall from a horse, with exposure of </span>subcutaneous tissue prior to healing. Within 5 years, they had all developed an atrophic erythematous annular plaque with papular and telangiectatic edges, with recurrent episodes of </span>ulceration<span><span><span> and scarring. Repeated tests for infectious agents were negative. Histological examinations showed granulomas and necrobiosis with palisading or early-stage palisading. Partial healing was achieved in two patients after 6 months of </span>doxycycline<span>. Treatment with </span></span>adalimumab resulted in disappearance of the ulcers at 6 months in one patient.</span></p></div><div><h3>Discussion</h3><p>Unusual sites of NL impose consideration of other types of palisading granuloma or mycobacterial infections<span><span>, which we were able to rule out. Two other cases of NL of the elbow similar to ours are reported in the literature. These cases, involving multiple ulcerations over a very long period of time, probably constitute a distinct entity because of the very distinct character of these 6 cases. Tetracyclines are partially active and </span>tumour necrosis factor alpha (TNF)-alpha inhibitors may offer an option.</span></p></div>","PeriodicalId":7900,"journal":{"name":"Annales De Dermatologie Et De Venereologie","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9489984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-01DOI: 10.1016/j.annder.2023.03.006
Nicolas Kluger
{"title":"Failure of dupilumab in a severe case of hidradenitis suppurativa","authors":"Nicolas Kluger","doi":"10.1016/j.annder.2023.03.006","DOIUrl":"10.1016/j.annder.2023.03.006","url":null,"abstract":"","PeriodicalId":7900,"journal":{"name":"Annales De Dermatologie Et De Venereologie","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9522526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-01DOI: 10.1016/j.annder.2022.12.001
P. Watson, M. Lamiaux, D. Lebas, P. Modiano
{"title":"Stevens-Johnson syndrome induced by lacosamide: A rare adverse reaction","authors":"P. Watson, M. Lamiaux, D. Lebas, P. Modiano","doi":"10.1016/j.annder.2022.12.001","DOIUrl":"10.1016/j.annder.2022.12.001","url":null,"abstract":"","PeriodicalId":7900,"journal":{"name":"Annales De Dermatologie Et De Venereologie","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9615265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-01DOI: 10.1016/j.annder.2023.06.001
L. Gosse , B. Sterling , V. Liabeuf , M.-P. Lehucher-Michel , C. Gaudy , M.-A. Richard
{"title":"Allergy activity in the dermatology department of a French university hospital over a 2-year period: A retrospective study of 1813 patients","authors":"L. Gosse , B. Sterling , V. Liabeuf , M.-P. Lehucher-Michel , C. Gaudy , M.-A. Richard","doi":"10.1016/j.annder.2023.06.001","DOIUrl":"10.1016/j.annder.2023.06.001","url":null,"abstract":"","PeriodicalId":7900,"journal":{"name":"Annales De Dermatologie Et De Venereologie","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10014569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-01DOI: 10.1016/j.annder.2023.01.002
N. Kluger, M. Marcaillou, V. Sibaud
{"title":"Nivolumab-induced poliosis restricted to a tattoo: A coincidental association?","authors":"N. Kluger, M. Marcaillou, V. Sibaud","doi":"10.1016/j.annder.2023.01.002","DOIUrl":"10.1016/j.annder.2023.01.002","url":null,"abstract":"","PeriodicalId":7900,"journal":{"name":"Annales De Dermatologie Et De Venereologie","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9573752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-01DOI: 10.1016/j.annder.2023.03.002
C. Breton, L. Gusdorf, A. Durlach, M. Viguier
{"title":"Occurrence of O’Brien-type annular elastolytic giant cell granuloma during pravastatin treatment illustrating statin-induced photosensitivity","authors":"C. Breton, L. Gusdorf, A. Durlach, M. Viguier","doi":"10.1016/j.annder.2023.03.002","DOIUrl":"10.1016/j.annder.2023.03.002","url":null,"abstract":"","PeriodicalId":7900,"journal":{"name":"Annales De Dermatologie Et De Venereologie","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9409041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-01DOI: 10.1016/j.annder.2023.03.007
C. Mauguen , A. Maruani , S. Barbarot , C. Abasq , L. Martin , J. Herbert , T. Goronflot , P.-A. Gourraud , A. Happe , A. Descatha , J.-M. Chrétien , A. Beuchée , H. Adamski , A. Dupuy , G. Bouzillé , E. Oger , C. Droitcourt
Background
The factors associated with early relapse of infantile haemangioma (IH) after a first course of treatment with oral propranolol for at least six months (initiated after the marketing authorization had been granted) have not previously been investigated.
Objectives
To identify factors associated with the risk of early relapse in children with IH treated with oral propranolol according to the current prescribing guidelines.
Methods
We performed a multicentre, retrospective, case-control study, using the Ouest Data Hub database. All children treated for at least 6 months with oral propranolol for IH between 31 June 2014 and 31 December 2021, and with a follow-up visit at least three months after treatment discontinuation were included. A case was defined as relapse of IH within three months of treatment discontinuation; each case was matched for age at treatment initiation and for centre, with four (relapse-free) controls. The association between relapse and treatment or IH characteristics was expressed as an odds ratio (OR) from univariate and multivariate conditional logistic regressions.
Results
A total of 225 children were included. Of these, 36 (16%) relapsed early. In a multivariate analysis, a deep IH component was a risk factor for early relapse [OR = 8.93; 95%CI: 1.0–78.9, p = 0.05]. A propranolol dosage level of less than 3 mg/kg/day protected against early relapse [OR = 0.11; 95%CI: 0.02–0.7, p = 0.02]. Tapering before propranolol discontinuation was not associated with a lower risk of early relapse.
Conclusion
The risk factors for late and early relapse are probably different. Investigation of the risk factors for early vs. late IH relapse is now warranted.
{"title":"Factors associated with early relapse of infantile haemangioma in children treated for at least six months with oral propranolol: A case-control study using the 2014–2021 French Ouest DataHub","authors":"C. Mauguen , A. Maruani , S. Barbarot , C. Abasq , L. Martin , J. Herbert , T. Goronflot , P.-A. Gourraud , A. Happe , A. Descatha , J.-M. Chrétien , A. Beuchée , H. Adamski , A. Dupuy , G. Bouzillé , E. Oger , C. Droitcourt","doi":"10.1016/j.annder.2023.03.007","DOIUrl":"10.1016/j.annder.2023.03.007","url":null,"abstract":"<div><h3>Background</h3><p><span><span>The factors associated with early relapse of infantile haemangioma (IH) after a first course of </span>treatment with oral </span>propranolol for at least six months (initiated after the marketing authorization had been granted) have not previously been investigated.</p></div><div><h3>Objectives</h3><p>To identify factors associated with the risk of early relapse in children with IH treated with oral propranolol according to the current prescribing guidelines.</p></div><div><h3>Methods</h3><p>We performed a multicentre, retrospective, case-control study, using the Ouest Data Hub database. All children treated for at least 6 months with oral propranolol for IH between 31 June 2014 and 31 December 2021, and with a follow-up visit at least three months after treatment discontinuation were included. A case was defined as relapse of IH within three months of treatment discontinuation; each case was matched for age at treatment initiation and for centre, with four (relapse-free) controls. The association between relapse and treatment or IH characteristics was expressed as an odds ratio (OR) from univariate and multivariate conditional logistic regressions.</p></div><div><h3>Results</h3><p>A total of 225 children were included. Of these, 36 (16%) relapsed early. In a multivariate analysis, a deep IH component was a risk factor for early relapse [OR = 8.93; 95%CI: 1.0–78.9, p = 0.05]. A propranolol dosage level of less than 3 mg/kg/day protected against early relapse [OR = 0.11; 95%CI: 0.02–0.7, p = 0.02]. Tapering before propranolol discontinuation was not associated with a lower risk of early relapse.</p></div><div><h3>Conclusion</h3><p>The risk factors for late and early relapse are probably different. Investigation of the risk factors for early vs. late IH relapse is now warranted.</p></div>","PeriodicalId":7900,"journal":{"name":"Annales De Dermatologie Et De Venereologie","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9516760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-01DOI: 10.1016/j.annder.2023.03.008
S. Karaa, C. Cassius, M. Jachiet, T. Mahevas, E. Charvet, O. Benveniste, J.-D. Bouaziz
{"title":"Efficacy of Janus kinase 1 and 2 inhibitor baricitinib in multirefractory cutaneous dermatomyositis","authors":"S. Karaa, C. Cassius, M. Jachiet, T. Mahevas, E. Charvet, O. Benveniste, J.-D. Bouaziz","doi":"10.1016/j.annder.2023.03.008","DOIUrl":"10.1016/j.annder.2023.03.008","url":null,"abstract":"","PeriodicalId":7900,"journal":{"name":"Annales De Dermatologie Et De Venereologie","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9526719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-01DOI: 10.1016/j.annder.2022.11.010
I. Matcaşu , N. Haddad , B. Barrou , F. Conti , S. Barete
{"title":"Biotherapies for chronic inflammatory dermatosis in organ transplant recipients: 3 case reports and a literature review","authors":"I. Matcaşu , N. Haddad , B. Barrou , F. Conti , S. Barete","doi":"10.1016/j.annder.2022.11.010","DOIUrl":"10.1016/j.annder.2022.11.010","url":null,"abstract":"","PeriodicalId":7900,"journal":{"name":"Annales De Dermatologie Et De Venereologie","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10702257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-01DOI: 10.1016/j.annder.2023.02.005
V. Da Silva Dias, O. Lafargue, A. Dompmartin
Aims
The primary objective was to study long-term outcomes in children with idiopathic facial aseptic granuloma (IFAG). The secondary objectives were to describe the clinical polymorphism of this entity, the different therapeutic options, and the occurrence of rosacea in this population.
Methods
We selected patients with a clinical diagnosis of IFAG seen in two different hospitals in Normandy between March 2016 and February 2021, and we collected clinical and therapeutic data from computerized medical records. A remote consultation based on recent photographs was performed to collect new data, and the children’s parents were asked to complete a questionnaire between February and August 2021.
Results
Ten children were included in this study. Nine patients presented with a single red to purplish nodule. One patient presented multiple papulopustular plaques. IFAG healed spontaneously without major sequelae, and this outcome was not influenced by any treatments. During follow-up, two patients developed childhood rosacea.
Conclusion
Although some clinical heterogeneity exists, early diagnosis and follow-up of IFAG is necessary to avoid unnecessary topical or systemic antibiotic treatments that do not shorten the disease course. IFAG appears to be a possible mode of entry for infantile rosacea.
{"title":"Idiopathic facial aseptic granuloma in children: Management and long-term follow-up","authors":"V. Da Silva Dias, O. Lafargue, A. Dompmartin","doi":"10.1016/j.annder.2023.02.005","DOIUrl":"10.1016/j.annder.2023.02.005","url":null,"abstract":"<div><h3>Aims</h3><p>The primary objective was to study long-term outcomes in children with idiopathic facial aseptic granuloma (IFAG). The secondary objectives were to describe the clinical polymorphism of this entity, the different therapeutic options, and the occurrence of rosacea in this population.</p></div><div><h3>Methods</h3><p>We selected patients with a clinical diagnosis of IFAG seen in two different hospitals in Normandy between March 2016 and February 2021, and we collected clinical and therapeutic data from computerized medical records<span>. A remote consultation based on recent photographs was performed to collect new data, and the children’s parents were asked to complete a questionnaire between February and August 2021.</span></p></div><div><h3>Results</h3><p>Ten children were included in this study. Nine patients presented with a single red to purplish nodule. One patient presented multiple papulopustular<span> plaques. IFAG healed spontaneously without major sequelae<span>, and this outcome was not influenced by any treatments. During follow-up, two patients developed childhood rosacea.</span></span></p></div><div><h3>Conclusion</h3><p>Although some clinical heterogeneity exists, early diagnosis and follow-up of IFAG is necessary to avoid unnecessary topical or systemic antibiotic treatments that do not shorten the disease course. IFAG appears to be a possible mode of entry for infantile rosacea.</p></div>","PeriodicalId":7900,"journal":{"name":"Annales De Dermatologie Et De Venereologie","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9615269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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