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An atypical association of lichen planus pigmentosus and bullous lichen planus 色素性扁平苔藓与大疱性扁平苔藓的非典型关联
IF 0.9 4区 医学 Q3 Medicine Pub Date : 2024-03-19 DOI: 10.1016/j.annder.2024.103262
M. Bouquerel , E. Baubion , L. Dufrenot Petitjean Roget , E. Amazan , N. Olivier
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引用次数: 0
Steven Johnson Syndrome in a child caused by typhoid fever 伤寒导致的儿童史蒂芬-约翰逊综合征
IF 0.9 4区 医学 Q3 Medicine Pub Date : 2024-03-19 DOI: 10.1016/j.annder.2024.103261
A.M. Putera, A. Endaryanto
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引用次数: 0
Acknowledgements to the reviewers 向审稿人致谢
IF 0.9 4区 医学 Q3 Medicine Pub Date : 2024-03-01 DOI: 10.1016/j.annder.2024.103278
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引用次数: 0
Adenopathy and Extensive Skin patch Overlaying a Plasmacytoma and other proliferation (AESOP) syndrome associated with Hodgkin lymphoma 与霍奇金淋巴瘤相关的腺病和大面积皮肤斑块叠加浆细胞瘤及其他增生(AESOP)综合征
IF 0.9 4区 医学 Q3 Medicine Pub Date : 2024-03-01 DOI: 10.1016/j.annder.2024.103256
J. Saucereau, C. Legeas, P. Schoenlaub
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引用次数: 0
Impact of direct use of artificial intelligence algorithms on patient autonomy in dermatology 直接使用人工智能算法对皮肤科患者自主权的影响
IF 0.9 4区 医学 Q3 Medicine Pub Date : 2024-03-01 DOI: 10.1016/j.annder.2024.103245
S. Karaa
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引用次数: 0
Clinicopathological, dermoscopic features and circumstances of diagnosis of amelanotic or hypomelanotic melanoma: A prospective multicentric study in the French private medical sector 黑色素瘤或黑素细胞减少症的临床病理学、皮肤镜特征和诊断情况:法国私立医疗机构的一项前瞻性多中心研究
IF 0.9 4区 医学 Q3 Medicine Pub Date : 2024-03-01 DOI: 10.1016/j.annder.2024.103249
E. Lorier Roy , J.-Y. Gourhant , C. Derancourt , N. Jouan , A. Dupuy , J.-F. Séi , on behalf of the Fédération Française de Formation Continue en Dermato-Vénéréologie

Background

Amelanotic or hypomelanotic melanomas (AHM) are difficult to diagnose, and are often diagnosed late, with a high Breslow index and a poor prognosis.

Patients and methods

A total of 226 volunteer dermatologists consulting in private practice in France completed an online form for each new histologically proven case of melanoma diagnosed at their clinic in 2020. This anonymised survey collected data on the clinical, dermoscopic, and histological features of melanoma, as well as the circumstances of diagnosis and initial management. A group of 145 AHM was single out and compared to the 1503 pigmented melanomas (PM) from the same cohort.

Results

1503 pigmented melanomas (PM) and 145 AHM (8.8% of these melanomas) were identified and included. In the AHM group, the mean age at diagnosis was 65 ± 16 years, with no significant difference from the PM control group. AHM were not predominantly on the face and neck area, and there were no differences based on gender. Warning signs (local progression and bleeding) were significantly more frequent in the AHM group than in the PM group. AHM were more frequently ulcerated and nodular, with a higher median Breslow thickness than in the PM group (1.56 vs. 0.5 mm), and mitoses were more frequent. Dermoscopy was widely used and proved useful for distinguishing benign lesions, and for highlighting the vascular polymorphous pattern of malignant lesions. Patients noticed the suspicious lesion themselves in most cases of AHM (73.2%), as opposed to their general practitioner (17.2%) or entourage (9.5%). A total body skin examination enabled detection of 19.3% of AHM and 21.3% of PM where the patient consulted for another lesion, or for an unrelated reason.

Conclusion

AHM are difficult to diagnose for the clinician because of the paucity or absence of pigmentary criteria. Knowledge of dermoscopic vascular patterns is critical and could help reduce the median Breslow index of AHM at the time of detection. Self-examination of the skin should be encouraged, and simple algorithms for earlier detection of skin cancers should be promoted among health professionals and the general population.

背景黑色素瘤(AHM)很难诊断,而且往往诊断较晚,布瑞斯勒指数较高,预后较差。患者和方法共有226名法国私人诊所的皮肤科医生志愿者填写了一份在线表格,内容涉及2020年在其诊所诊断的每一例经组织学证实的黑色素瘤新病例。这项匿名调查收集了有关黑色素瘤的临床、皮肤镜检查和组织学特征以及诊断和初步治疗情况的数据。结果 1503 例色素性黑色素瘤(PM)和 145 例 AHM(占黑色素瘤的 8.8%)被确定并纳入调查。在AHM组中,确诊时的平均年龄为65 ± 16岁,与PM对照组无明显差异。AHM并非主要发生在面部和颈部,也没有性别差异。AHM组的预警信号(局部恶化和出血)明显多于PM组。AHM更常见于溃疡和结节,布瑞斯洛厚度中位数高于PM组(1.56毫米对0.5毫米),有丝分裂也更常见。皮肤镜被广泛使用,并被证明有助于区分良性病变,以及突出显示恶性病变的血管多形性模式。大多数 AHM 病例(73.2%)的可疑病变是患者自己发现的,而不是由普通医生(17.2%)或随行人员(9.5%)发现的。通过全身皮肤检查,19.3%的AHM和21.3%的PM被检出,而患者是因其他病变或与此无关的原因就诊的。了解皮肤镜下的血管形态至关重要,有助于降低发现 AHM 时的中位布雷斯罗指数。应鼓励进行皮肤自我检查,并向医疗专业人员和普通民众推广早期发现皮肤癌的简单算法。
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引用次数: 0
Correlation of serum level of squamous cell carcinoma antigen with severity of cutaneous psoriasis, assessed using the simplified psoriasis index 使用简化银屑病指数评估血清鳞状细胞癌抗原水平与皮肤银屑病严重程度的相关性
IF 0.9 4区 医学 Q3 Medicine Pub Date : 2024-03-01 DOI: 10.1016/j.annder.2024.103246
D. Henry , A. Alkhars , M. Samimi , D. Dufour , L. Machet

Background

Squamous cell carcinoma antigen (SCCA) is a biomarker of disease progression in squamous cell carcinoma but also contributes to the pathogenesis of psoriasis. Eight previous studies have shown a correlation between psoriasis severity, assessed using the Psoriasis Assessment Severity Index or body surface area, and serum level of SCCA, mainly SCCA2, assessed by means of non-commercial tests. We examined the correlation between serum SCCA level, measured with a commercial kit, and psoriasis severity assessed using the Simplified Psoriasis Index (SPI).

Methods

We conducted a prospective, non-interventional, single-centre study at the University Hospital of Tours over 18 months. The primary endpoint was same-day measurement of serum SCCA level and the psoriasis severity score on the professional version of the SPI (proSPI-s) at both baseline and follow-up. Secondary endpoints were same-day measurement of serum SCCA level and the proSPI psychosocial score (proSPI-p), proSPI treatment score, Dermatology Life Quality Index (DLQI), and inflammation parameters (C-reactive protein level, neutrophil-to-lymphocyte ratio).

Results

We included 50 psoriasis patients. Serum SCCA level was correlated with the proSPI-s at baseline and follow-up (Spearman r = 0.686 and r = 0.674, p < 0.0001) for both. It was correlated with the proSPI-p and DLQI. Serum SCCA level was not correlated with either neutrophil-to-lymphocyte ratio (r = 0.083) or C-reactive protein level (r = 0.192).

Conclusion

This study is the first to correlate serum SCCA level with proSPI-s. Moreover, SCCA was measured using a widely available kit. SCCA may be used to assess the severity of psoriasis.

背景鳞状细胞癌抗原(SCCA)是鳞状细胞癌疾病进展的生物标志物,同时也是银屑病的发病机制之一。之前的八项研究显示,使用银屑病评估严重程度指数或体表面积评估的银屑病严重程度与通过非商业测试评估的血清 SCCA(主要是 SCCA2)水平之间存在相关性。我们研究了使用商业试剂盒测量的血清 SCCA 水平与使用银屑病简化指数 (SPI) 评估的银屑病严重程度之间的相关性。研究的主要终点是当天测量的血清 SCCA 水平,以及基线和随访期间专业版 SPI(proSPI-s)的银屑病严重程度评分。次要终点是当天测量的血清SCCA水平和proSPI社会心理评分(proSPI-p)、proSPI治疗评分、皮肤科生活质量指数(DLQI)以及炎症参数(C反应蛋白水平、中性粒细胞与淋巴细胞比率)。血清 SCCA 水平与基线和随访时的 proSPI-s 相关(Spearman r = 0.686 和 r = 0.674,p < 0.0001)。它与proSPI-p和DLQI相关。血清 SCCA 水平与中性粒细胞与淋巴细胞比率(r = 0.083)或 C 反应蛋白水平(r = 0.192)均无相关性。此外,SCCA 是通过一种广泛使用的试剂盒测定的。SCCA 可用于评估银屑病的严重程度。
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引用次数: 0
Dermoscopy for lipidized dermatofibroma: A useful diagnostic tool 皮肤镜检查脂质化皮肤纤维瘤:一种有用的诊断工具
IF 0.9 4区 医学 Q3 Medicine Pub Date : 2024-03-01 DOI: 10.1016/j.annder.2024.103250
C.H. Na, J.H. Seo, M.S. Kim, B.S. Shin, H. Choi
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引用次数: 0
Alternative or complementary Medicines: Whether to work alongside them or reject them outright - an ethical dilemma 替代或补充药物:是与之并肩作战还是断然拒绝--道德难题
IF 0.9 4区 医学 Q3 Medicine Pub Date : 2024-03-01 DOI: 10.1016/j.annder.2024.103258
A. Petit, D. Penso-Assathiany, L. Hefez, the Ethics Group of the French Dermatology Society GéD
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引用次数: 0
Characteristics of atopic dermatitis patients using complementary and alternative medicine: A literature review 使用补充和替代医学的特应性皮炎患者的特征:文献综述
IF 0.9 4区 医学 Q3 Medicine Pub Date : 2024-03-01 DOI: 10.1016/j.annder.2024.103257
C. Delhomme , T. Adam , H. Seiller , A.-C. Bursztejn

Background

Atopic dermatitis (AD) is a chronic inflammatory skin disease. Due to the burden of the disease, some patients try complementary and alternative medicine (CAM).

Objective

To identify characteristics associated with CAM use in children and adults with AD.

Methods

We conducted a literature review in accordance with the PRISMA international guidelines for literature reviews and meta-analyses. A systematic search was performed in the PubMed database. Qualitative and quantitative analyses using a χ2 test were performed to compare characteristics between CAM users and non-users. A p-value of <0.05 was considered statistically significant.

Results

Out of 514 articles retrieved, 12 studies were included, giving a total of 2240 patients. Our statistical analysis identified an association between CAM use and rhino-conjunctivitis (p = 0.015 in children, p = 0.041 in adults), topical corticosteroid use (p = 0.042 in children, p = 0.008 in adults), and daily application of moisturizing cream (p = 0.002 in children, p < 0.001 in adults). Gender did not affect the decision to use CAM (p > 0.05). In studies, a higher number of affected eczema sites (p < 0.001), prior use of more than two conventional treatments (p = 0.047), and food avoidance diets (p = 0.016) were predictive of CAM use in children. In adults, a younger age (p < 0.05), higher education level (p = 0.043), and lower age at AD onset (p = 0.004) were related to CAM use.

Discussion

To our knowledge, this is the first literature review focusing on socio-demographic and disease determinants related to CAM use among AD patients. The lack of homogeneity in measuring tools makes it difficult to compare and synthesize the studies.

背景特应性皮炎(AD)是一种慢性炎症性皮肤病。方法我们根据 PRISMA 国际文献综述和荟萃分析指南进行了文献综述。在 PubMed 数据库中进行了系统检索。使用χ2检验进行定性和定量分析,比较CAM使用者和非使用者的特征。结果在检索到的 514 篇文章中,有 12 项研究被纳入,共计 2240 名患者。我们的统计分析表明,CAM 的使用与犀牛结膜炎(儿童 p = 0.015,成人 p = 0.041)、局部皮质类固醇的使用(儿童 p = 0.042,成人 p = 0.008)以及每天使用保湿霜(儿童 p = 0.002,成人 p <0.001)之间存在关联。性别并不影响使用 CAM 的决定(p > 0.05)。在研究中,受影响的湿疹部位越多(p <0.001)、之前使用过两种以上的常规治疗方法(p = 0.047)和忌食(p = 0.016)对儿童使用 CAM 有预测作用。据我们所知,这是第一篇关注与 AD 患者使用 CAM 相关的社会人口学和疾病决定因素的文献综述。由于测量工具缺乏一致性,因此很难对这些研究进行比较和综合。
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Annales De Dermatologie Et De Venereologie
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