Annales De Dermatologie Et De Venereologie最新文献

{"title":"Subungual metastasis of melanoma","authors":"F.K. Pham , G. Chidiac , J. Tantot , L. Thomas","doi":"10.1016/j.annder.2025.103455","DOIUrl":"10.1016/j.annder.2025.103455","url":null,"abstract":"","PeriodicalId":7900,"journal":{"name":"Annales De Dermatologie Et De Venereologie","volume":"153 1","pages":"Article 103455"},"PeriodicalIF":2.8,"publicationDate":"2025-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145786977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pregnancy following home-based intravaginal desensitization to human seminal plasma","authors":"O. Alemany , A. Belbézier , P. Pralong","doi":"10.1016/j.annder.2025.103456","DOIUrl":"10.1016/j.annder.2025.103456","url":null,"abstract":"","PeriodicalId":7900,"journal":{"name":"Annales De Dermatologie Et De Venereologie","volume":"153 1","pages":"Article 103456"},"PeriodicalIF":2.8,"publicationDate":"2025-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145802824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The first year of treatment with selumetinib for NF1-related plexiform neurofibroma is medically challenging in real-life settings","authors":"P. Boitez ,&nbsp;D. Farges ,&nbsp;M. Descamps ,&nbsp;V. Bournazel ,&nbsp;L. Martin","doi":"10.1016/j.annder.2025.103438","DOIUrl":"10.1016/j.annder.2025.103438","url":null,"abstract":"<div><h3>Background</h3><div>Plexiform neurofibromas (PNFs) occur in 20–50 % of NF1 patients and can alter skin appearance and/or invade adjacent structures. These tumors grow rapidly in childhood, leading to significant morbidity. Surgical treatment is recommended as first-line therapy, but complete resection is not always possible, and the risk of recurrence is high. Selumetinib is a selective inhibitor of MEK protein kinases that has been shown to reduce PNF tumor volume. It has been approved as monotherapy for the treatment of symptomatic inoperable PNF in children aged over 3 years. The aim of our study was to investigate the real-life efficacy and safety profile of selumetinib in a single-center cohort of NF1 patients with one or more symptomatic inoperable PNFs.</div></div><div><h3>Patients and methods</h3><div>Prior to treatment, patients underwent cardiac ultrasound, ophthalmological examination, biological tests, and baseline magnetic resonance imaging (MRI). Specific patient follow-up included a quarterly consultation (with comparative pictures) and a monthly teleconsultation for the first 4 months to discuss any adverse effects, give advice, and provide support to patients and their families. Monitoring included biological, ophthalmological, cardiological and radiological assessment.</div></div><div><h3>Results</h3><div>From a pediatric NF1 cohort of over one hundred children, we included 10 patients over the age of 18 months (median age 14 years − range 5 to 17 years). Morbidities engendered by PNFs were disfigurement (50 %), pain (30 %), visual impairment (20 %) (mainly amblyopia), hearing impairment (10 %), and balance disorders (10 %). Selumetinib was administered at a dose of 25 mg/m²/day. After a median follow-up period of 19.5 months (±6.6 months), tumor volume shrinkage was observed clinically in 6 cases, stability in 2 cases, and volume growth in 2 cases.</div><div>Adverse events were mainly cutaneous (70 %), with acneiform rashes (60 %), xerosis cutis (20 %), alopecia (20 %), paronychia (10 %) and eczematous rash (10 %). Four patients (40 %) presented gastrointestinal disorders at the start of treatment. All these effects corresponded to grade 1 toxicity. No ocular or cardiac toxicity was detected.</div></div><div><h3>Discussion</h3><div>Our efficacy results at 19.5 months for selumetinib show a genuine but modest reduction in PNF volume. The treatment has a good safety profile. While it is very common for adverse events to be reported at the start of treatment, they are of moderate severity and are managed by dose reduction or simple symptomatic treatment. Starting treatment early in life appears to lead to a more favorable outcome and should be considered.</div></div>","PeriodicalId":7900,"journal":{"name":"Annales De Dermatologie Et De Venereologie","volume":"153 1","pages":"Article 103438"},"PeriodicalIF":2.8,"publicationDate":"2025-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145780158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Allergological work-up of severe cutaneous adverse reactions with suspicion of anxiolytics or sleeping pills. A multicenter retrospective study of 20 cases","authors":"S. Ingen-Housz-Oro ,&nbsp;F. Dezoteux ,&nbsp;C. Bernier ,&nbsp;E. Le Bidre ,&nbsp;D. Staumont-Sallé ,&nbsp;A. Welfringer-Morin ,&nbsp;V. Beaulieu ,&nbsp;M. Tauber ,&nbsp;K. Bel Hareth ,&nbsp;H. Assier","doi":"10.1016/j.annder.2025.103398","DOIUrl":"10.1016/j.annder.2025.103398","url":null,"abstract":"","PeriodicalId":7900,"journal":{"name":"Annales De Dermatologie Et De Venereologie","volume":"152 4","pages":"Article 103398"},"PeriodicalIF":2.8,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145601732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Skin ultra-sound: Its history and advances","authors":"J. Chauvel-Picard ,&nbsp;A.Gleizal ,&nbsp;H. Zahouani ,&nbsp;L. Tognetti ,&nbsp;E. Cinott ,&nbsp;E. Lange ,&nbsp;M. Suppa ,&nbsp;P. Rubegni ,&nbsp;V.Del Marmol ,&nbsp;C. Raffaelli ,&nbsp;P. Bahadoran ,&nbsp;J.-L. Perrot","doi":"10.1016/j.annder.2025.103437","DOIUrl":"10.1016/j.annder.2025.103437","url":null,"abstract":"<div><div>Skin ultrasound imaging has proven its complementarity with in vivo dermatoscopic and microscopic clinical dermatological examination in obtaining additional informations on the deep component of different skin pathologies. It is a reliable and non-invasive tool for evaluating the overall morphology of skin tumors or other pathologies such as Verneuil’s disease or other cystic pathologies.This article resumes the history of skin ultrasound imaging, its technical specificities and its practical uses. Optical imaging is not discussed, for which an article has already been devoted to it.</div></div>","PeriodicalId":7900,"journal":{"name":"Annales De Dermatologie Et De Venereologie","volume":"152 4","pages":"Article 103437"},"PeriodicalIF":2.8,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145601720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical photography in dermatology: An ethical challenge","authors":"E. Demoulins ,&nbsp;M. Moyal-Barracco ,&nbsp;D. Penso-Assathiany ,&nbsp;Groupe de Réflexion Éthique en Dermatologie GÉD of the French Society of Dermatology","doi":"10.1016/j.annder.2025.103435","DOIUrl":"10.1016/j.annder.2025.103435","url":null,"abstract":"","PeriodicalId":7900,"journal":{"name":"Annales De Dermatologie Et De Venereologie","volume":"152 4","pages":"Article 103435"},"PeriodicalIF":2.8,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145601745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Autoimmune bullous dermatosis in children: French guidelines","authors":"A. Welfringer-Morin ,&nbsp;B. Tedbirt ,&nbsp;H. Aubert ,&nbsp;E. Abi-Nader ,&nbsp;B. Pigneur ,&nbsp;A.-C. Bursztejn ,&nbsp;C. Droitcourt ,&nbsp;L. Gusdorf ,&nbsp;C. Le Roux-Villet ,&nbsp;S. Mallet ,&nbsp;S. Ingen-Housz-Oro ,&nbsp;C. Prost-Squarcioni ,&nbsp;C. Bodemer ,&nbsp;P. Joly","doi":"10.1016/j.annder.2025.103396","DOIUrl":"10.1016/j.annder.2025.103396","url":null,"abstract":"","PeriodicalId":7900,"journal":{"name":"Annales De Dermatologie Et De Venereologie","volume":"152 4","pages":"Article 103396"},"PeriodicalIF":2.8,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145601680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Penile necrosis after intravesical instillation of mitomycin C","authors":"L. Galissi ,&nbsp;V. Orlandini ,&nbsp;P. Cirotteau ,&nbsp;A. Pham-Ledard ,&nbsp;M. Beylot-Barry","doi":"10.1016/j.annder.2025.103450","DOIUrl":"10.1016/j.annder.2025.103450","url":null,"abstract":"","PeriodicalId":7900,"journal":{"name":"Annales De Dermatologie Et De Venereologie","volume":"153 1","pages":"Article 103450"},"PeriodicalIF":2.8,"publicationDate":"2025-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145622337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multicentric reticulohistiocytosis associated with metastatic melanoma: Therapeutic challenges","authors":"N. Syyli ,&nbsp;L. Tolkki ,&nbsp;K. Suontama-Uusitalo ,&nbsp;N. Kluger","doi":"10.1016/j.annder.2025.103448","DOIUrl":"10.1016/j.annder.2025.103448","url":null,"abstract":"","PeriodicalId":7900,"journal":{"name":"Annales De Dermatologie Et De Venereologie","volume":"153 1","pages":"Article 103448"},"PeriodicalIF":2.8,"publicationDate":"2025-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145622339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hydroxyurea-induced rosacea-like eruption in polycythemia vera","authors":"X.-K. Xu,&nbsp;C.-R. Xiao,&nbsp;Y-Y Lin,&nbsp;H. Kang,&nbsp;L.-J. Su","doi":"10.1016/j.annder.2025.103449","DOIUrl":"10.1016/j.annder.2025.103449","url":null,"abstract":"","PeriodicalId":7900,"journal":{"name":"Annales De Dermatologie Et De Venereologie","volume":"153 1","pages":"Article 103449"},"PeriodicalIF":2.8,"publicationDate":"2025-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145622340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}