Pub Date : 2019-05-19DOI: 10.1146/annurev-conmatphys-031218-013516
Ricard Alert, X. Trepat
Collective cell migration is a key driver of embryonic development, wound healing, and some types of cancer invasion. Here, we provide a physical perspective of the mechanisms underlying collective cell migration. We begin with a catalog of the cell–cell and cell–substrate interactions that govern cell migration, which we classify into positional and orientational interactions. We then review the physical models that have been developed to explain how these interactions give rise to collective cellular movement. These models span the subcellular to the supracellular scales, and they include lattice models, phase-field models, active network models, particle models, and continuum models. For each type of model, we discuss its formulation, its limitations, and the main emergent phenomena that it has successfully explained. These phenomena include flocking and fluid–solid transitions, as well as wetting, fingering, and mechanical waves in spreading epithelial monolayers. We close by outlining remaining challenges and future directions in the physics of collective cell migration.
{"title":"Physical Models of Collective Cell Migration","authors":"Ricard Alert, X. Trepat","doi":"10.1146/annurev-conmatphys-031218-013516","DOIUrl":"https://doi.org/10.1146/annurev-conmatphys-031218-013516","url":null,"abstract":"Collective cell migration is a key driver of embryonic development, wound healing, and some types of cancer invasion. Here, we provide a physical perspective of the mechanisms underlying collective cell migration. We begin with a catalog of the cell–cell and cell–substrate interactions that govern cell migration, which we classify into positional and orientational interactions. We then review the physical models that have been developed to explain how these interactions give rise to collective cellular movement. These models span the subcellular to the supracellular scales, and they include lattice models, phase-field models, active network models, particle models, and continuum models. For each type of model, we discuss its formulation, its limitations, and the main emergent phenomena that it has successfully explained. These phenomena include flocking and fluid–solid transitions, as well as wetting, fingering, and mechanical waves in spreading epithelial monolayers. We close by outlining remaining challenges and future directions in the physics of collective cell migration.","PeriodicalId":7925,"journal":{"name":"Annual Review of Condensed Matter Physics","volume":" ","pages":""},"PeriodicalIF":22.6,"publicationDate":"2019-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev-conmatphys-031218-013516","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47190982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-05-10DOI: 10.1146/annurev-conmatphys-031119-050651
G. Torlai, R. Melko
We review the development of generative modeling techniques in machine learning for the purpose of reconstructing real, noisy, many-qubit quantum states. Motivated by its interpretability and utility, we discuss in detail the theory of the restricted Boltzmann machine. We demonstrate its practical use for state reconstruction, starting from a classical thermal distribution of Ising spins, then moving systematically through increasingly complex pure and mixed quantum states. We review recent techniques in reconstruction of a cold atom wavefunction, intended for use on experimental noisy intermediate-scale quantum (NISQ) devices. Finally, we discuss the outlook for future experimental state reconstruction using machine learning in the NISQ era and beyond.
{"title":"Machine-Learning Quantum States in the NISQ Era","authors":"G. Torlai, R. Melko","doi":"10.1146/annurev-conmatphys-031119-050651","DOIUrl":"https://doi.org/10.1146/annurev-conmatphys-031119-050651","url":null,"abstract":"We review the development of generative modeling techniques in machine learning for the purpose of reconstructing real, noisy, many-qubit quantum states. Motivated by its interpretability and utility, we discuss in detail the theory of the restricted Boltzmann machine. We demonstrate its practical use for state reconstruction, starting from a classical thermal distribution of Ising spins, then moving systematically through increasingly complex pure and mixed quantum states. We review recent techniques in reconstruction of a cold atom wavefunction, intended for use on experimental noisy intermediate-scale quantum (NISQ) devices. Finally, we discuss the outlook for future experimental state reconstruction using machine learning in the NISQ era and beyond.","PeriodicalId":7925,"journal":{"name":"Annual Review of Condensed Matter Physics","volume":" ","pages":""},"PeriodicalIF":22.6,"publicationDate":"2019-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev-conmatphys-031119-050651","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43492408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-05-03DOI: 10.1146/annurev-conmatphys-031218-013721
Fenner Harper, R. Roy, M. Rudner, S. Sondhi
Floquet systems are governed by periodic, time-dependent Hamiltonians. Prima facie they should absorb energy from the external drives involved in modulating their couplings and heat up to infinite temperature. However, this unhappy state of affairs can be avoided in many ways. Instead, as has become clear from much recent work, Floquet systems can exhibit a variety of nontrivial behavior—some of which is impossible in undriven systems. In this review, we describe the main ideas and themes of this work: novel Floquet drives that exhibit nontrivial topology in single-particle systems, the existence and classification of exotic Floquet drives in interacting systems, and the attendant notion of many-body Floquet phases and arguments for their stability to heating.
{"title":"Topology and Broken Symmetry in Floquet Systems","authors":"Fenner Harper, R. Roy, M. Rudner, S. Sondhi","doi":"10.1146/annurev-conmatphys-031218-013721","DOIUrl":"https://doi.org/10.1146/annurev-conmatphys-031218-013721","url":null,"abstract":"Floquet systems are governed by periodic, time-dependent Hamiltonians. Prima facie they should absorb energy from the external drives involved in modulating their couplings and heat up to infinite temperature. However, this unhappy state of affairs can be avoided in many ways. Instead, as has become clear from much recent work, Floquet systems can exhibit a variety of nontrivial behavior—some of which is impossible in undriven systems. In this review, we describe the main ideas and themes of this work: novel Floquet drives that exhibit nontrivial topology in single-particle systems, the existence and classification of exotic Floquet drives in interacting systems, and the attendant notion of many-body Floquet phases and arguments for their stability to heating.","PeriodicalId":7925,"journal":{"name":"Annual Review of Condensed Matter Physics","volume":" ","pages":""},"PeriodicalIF":22.6,"publicationDate":"2019-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev-conmatphys-031218-013721","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44215487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-04-22DOI: 10.1146/annurev-conmatphys-031119-050711
D. Agterberg, J. C. Davis, S. Edkins, E. Fradkin, D. Harlingen, S. Kivelson, P. Lee, L. Radzihovsky, J. Tranquada, Yuxuan Wang
We review the physics of pair-density wave (PDW) superconductors. We begin with a macroscopic description that emphasizes order induced by PDW states, such as charge-density wave, and discuss related vestigial states that emerge as a consequence of partial melting of the PDW order. We review and critically discuss the mounting experimental evidence for such PDW order in the cuprate superconductors, the status of the theoretical microscopic description of such order, and the current debate on whether the PDW is a mother order or another competing order in the cuprates. In addition, we give an overview of the weak coupling version of PDW order, Fulde–Ferrell–Larkin–Ovchinnikov states, in the context of cold atom systems, unconventional superconductors, and noncentrosymmetric and Weyl materials.
{"title":"The Physics of Pair-Density Waves: Cuprate Superconductors and Beyond","authors":"D. Agterberg, J. C. Davis, S. Edkins, E. Fradkin, D. Harlingen, S. Kivelson, P. Lee, L. Radzihovsky, J. Tranquada, Yuxuan Wang","doi":"10.1146/annurev-conmatphys-031119-050711","DOIUrl":"https://doi.org/10.1146/annurev-conmatphys-031119-050711","url":null,"abstract":"We review the physics of pair-density wave (PDW) superconductors. We begin with a macroscopic description that emphasizes order induced by PDW states, such as charge-density wave, and discuss related vestigial states that emerge as a consequence of partial melting of the PDW order. We review and critically discuss the mounting experimental evidence for such PDW order in the cuprate superconductors, the status of the theoretical microscopic description of such order, and the current debate on whether the PDW is a mother order or another competing order in the cuprates. In addition, we give an overview of the weak coupling version of PDW order, Fulde–Ferrell–Larkin–Ovchinnikov states, in the context of cold atom systems, unconventional superconductors, and noncentrosymmetric and Weyl materials.","PeriodicalId":7925,"journal":{"name":"Annual Review of Condensed Matter Physics","volume":" ","pages":""},"PeriodicalIF":22.6,"publicationDate":"2019-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev-conmatphys-031119-050711","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44987201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-04-19DOI: 10.1146/annurev-conmatphys-031119-050630
C. Rylands, N. Andrei
Driven by breakthroughs in experimental and theoretical techniques, the study of nonequilibrium quantum physics is a rapidly expanding field with many exciting new developments. Among the manifold ways the topic can be investigated, one-dimensional systems provide a particularly fine platform. The trifecta of strongly correlated physics, powerful theoretical techniques, and experimental viability have resulted in a flurry of research activity over the past decade or so. In this review, we explore the nonequilibrium aspects of one-dimensional systems that are integrable. Through a number of illustrative examples, we discuss nonequilibrium phenomena that arise in such models, the role played by integrability, and the consequences these have for more generic systems.
{"title":"Nonequilibrium Aspects of Integrable Models","authors":"C. Rylands, N. Andrei","doi":"10.1146/annurev-conmatphys-031119-050630","DOIUrl":"https://doi.org/10.1146/annurev-conmatphys-031119-050630","url":null,"abstract":"Driven by breakthroughs in experimental and theoretical techniques, the study of nonequilibrium quantum physics is a rapidly expanding field with many exciting new developments. Among the manifold ways the topic can be investigated, one-dimensional systems provide a particularly fine platform. The trifecta of strongly correlated physics, powerful theoretical techniques, and experimental viability have resulted in a flurry of research activity over the past decade or so. In this review, we explore the nonequilibrium aspects of one-dimensional systems that are integrable. Through a number of illustrative examples, we discuss nonequilibrium phenomena that arise in such models, the role played by integrability, and the consequences these have for more generic systems.","PeriodicalId":7925,"journal":{"name":"Annual Review of Condensed Matter Physics","volume":" ","pages":""},"PeriodicalIF":22.6,"publicationDate":"2019-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev-conmatphys-031119-050630","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47577958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-04-01DOI: 10.1146/annurev-conmatphys-031119-050644
Haruki Watanabe
When global continuous symmetries are spontaneously broken, there appear gapless collective excitations called Nambu–Goldstone modes (NGMs) that govern the low-energy property of the system. The application of this famous theorem ranges from high-energy particle physics to condensed matter and atomic physics. When a symmetry breaking occurs in systems that lack the Lorentz invariance to start with, as is usually the case in condensed matter systems, the number of resulting NGMs can be lower than that of broken symmetry generators, and the dispersion of NGMs is not necessarily linear. In this article, we review recently established formulae for NGMs associated with broken internal symmetries that work equally for relativistic and nonrelativistic systems. We also discuss complexities of NGMs originating from space-time symmetry breaking. Along the way we cover many illuminating examples from various context. We also present a complementary point of view from the Lieb–Schultz–Mattis theorem.
{"title":"Counting Rules of Nambu–Goldstone Modes","authors":"Haruki Watanabe","doi":"10.1146/annurev-conmatphys-031119-050644","DOIUrl":"https://doi.org/10.1146/annurev-conmatphys-031119-050644","url":null,"abstract":"When global continuous symmetries are spontaneously broken, there appear gapless collective excitations called Nambu–Goldstone modes (NGMs) that govern the low-energy property of the system. The application of this famous theorem ranges from high-energy particle physics to condensed matter and atomic physics. When a symmetry breaking occurs in systems that lack the Lorentz invariance to start with, as is usually the case in condensed matter systems, the number of resulting NGMs can be lower than that of broken symmetry generators, and the dispersion of NGMs is not necessarily linear. In this article, we review recently established formulae for NGMs associated with broken internal symmetries that work equally for relativistic and nonrelativistic systems. We also discuss complexities of NGMs originating from space-time symmetry breaking. Along the way we cover many illuminating examples from various context. We also present a complementary point of view from the Lieb–Schultz–Mattis theorem.","PeriodicalId":7925,"journal":{"name":"Annual Review of Condensed Matter Physics","volume":" ","pages":""},"PeriodicalIF":22.6,"publicationDate":"2019-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev-conmatphys-031119-050644","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46879965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-03-28DOI: 10.1146/annurev-conmatphys-031119-050821
L. Madeira, M. Caracanhas, F. E. A. Santos, V. Bagnato
Turbulence is characterized by a large number of degrees of freedom, distributed over several length scales, that result in a disordered state of a fluid. The field of quantum turbulence deals with the manifestation of turbulence in quantum fluids, such as liquid helium and ultracold gases. We review, from both experimental and theoretical points of view, advances in quantum turbulence focusing on atomic Bose–Einstein condensates. We also explore the similarities and differences between quantum and classical turbulence. Last, we present challenges and possible directions for the field. We summarize questions that are being asked in recent works, which need to be answered in order to understand fundamental properties of quantum turbulence, and we provide some possible ways of investigating them.
{"title":"Quantum Turbulence in Quantum Gases","authors":"L. Madeira, M. Caracanhas, F. E. A. Santos, V. Bagnato","doi":"10.1146/annurev-conmatphys-031119-050821","DOIUrl":"https://doi.org/10.1146/annurev-conmatphys-031119-050821","url":null,"abstract":"Turbulence is characterized by a large number of degrees of freedom, distributed over several length scales, that result in a disordered state of a fluid. The field of quantum turbulence deals with the manifestation of turbulence in quantum fluids, such as liquid helium and ultracold gases. We review, from both experimental and theoretical points of view, advances in quantum turbulence focusing on atomic Bose–Einstein condensates. We also explore the similarities and differences between quantum and classical turbulence. Last, we present challenges and possible directions for the field. We summarize questions that are being asked in recent works, which need to be answered in order to understand fundamental properties of quantum turbulence, and we provide some possible ways of investigating them.","PeriodicalId":7925,"journal":{"name":"Annual Review of Condensed Matter Physics","volume":"1 1","pages":""},"PeriodicalIF":22.6,"publicationDate":"2019-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev-conmatphys-031119-050821","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41940970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-03-11DOI: 10.1146/ANNUREV-CONMATPHYS-031218-013757
H. Turlier, T. Betz
Soft-condensed matter physics has provided, in the past decades, many of the relevant concepts and methods allowing successful description of living cells and biological tissues. This recent quantitative physical description of biological systems has profoundly advanced our understanding of life, which is shifting from a descriptive to a predictive level. Like other active materials investigated in condensed matter physics, biological materials still pose great challenges to modern physics as they form a specific class of nonequilibrium systems. Actively driven membranes have been studied for more than two decades, taking advantage of rapid progress in membrane physics and in the experimental development of reconstituted active membranes. The physical description of activity within living biological membranes remains, however, a key challenge that animates a dynamic research community, bringing together physicists and biologists. Here, we first review the past two decades of experimental and theoretical advances that enabled the characterization of mechanical properties and nonequilibrium fluctuations in active membranes. We distinguish active processes originating from membrane proteins or from external interactions, such as cytoskeletal forces. Then, we focus on the emblematic case of red blood cell flickering, the active origin of which has been debated for decades until recently. We finally close this review by discussing future challenges in this ever more interdisciplinary field.
{"title":"Unveiling the Active Nature of Living-Membrane Fluctuations and Mechanics","authors":"H. Turlier, T. Betz","doi":"10.1146/ANNUREV-CONMATPHYS-031218-013757","DOIUrl":"https://doi.org/10.1146/ANNUREV-CONMATPHYS-031218-013757","url":null,"abstract":"Soft-condensed matter physics has provided, in the past decades, many of the relevant concepts and methods allowing successful description of living cells and biological tissues. This recent quantitative physical description of biological systems has profoundly advanced our understanding of life, which is shifting from a descriptive to a predictive level. Like other active materials investigated in condensed matter physics, biological materials still pose great challenges to modern physics as they form a specific class of nonequilibrium systems. Actively driven membranes have been studied for more than two decades, taking advantage of rapid progress in membrane physics and in the experimental development of reconstituted active membranes. The physical description of activity within living biological membranes remains, however, a key challenge that animates a dynamic research community, bringing together physicists and biologists. Here, we first review the past two decades of experimental and theoretical advances that enabled the characterization of mechanical properties and nonequilibrium fluctuations in active membranes. We distinguish active processes originating from membrane proteins or from external interactions, such as cytoskeletal forces. Then, we focus on the emblematic case of red blood cell flickering, the active origin of which has been debated for decades until recently. We finally close this review by discussing future challenges in this ever more interdisciplinary field.","PeriodicalId":7925,"journal":{"name":"Annual Review of Condensed Matter Physics","volume":" ","pages":""},"PeriodicalIF":22.6,"publicationDate":"2019-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/ANNUREV-CONMATPHYS-031218-013757","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47373872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-03-11DOI: 10.1146/ANNUREV-CONMATPHYS-031218-013318
A. Libchaber
This article focuses on the history of theoretical ideas but also on the developments of experimental tools. The experiments in our laboratory are used to illustrate the various developments associated with Brownian movement. In the first part of this review, we give an overview of the theory. We insist on the pre-Einstein approach to the problem by Lord Rayleigh, Bachelier, and Smoluchowski. In the second part, we detail the achievements of Perrin, measuring Avogadro's number, quantifying the experimental observations of Brownian movement, and introducing the problem of continuous curves without tangent, a precursor to fractal theory. The third part deals with modern application of Brownian movement, escape from a fixed optical trap, particle dynamics on a moving trap, and finally development of Brownian thermal ratchets. Finally, we give a short overview of bacteria motion, presented like an active Brownian movement with very high effective temperature.
{"title":"From Biology to Physics and Back: The Problem of Brownian Movement","authors":"A. Libchaber","doi":"10.1146/ANNUREV-CONMATPHYS-031218-013318","DOIUrl":"https://doi.org/10.1146/ANNUREV-CONMATPHYS-031218-013318","url":null,"abstract":"This article focuses on the history of theoretical ideas but also on the developments of experimental tools. The experiments in our laboratory are used to illustrate the various developments associated with Brownian movement. In the first part of this review, we give an overview of the theory. We insist on the pre-Einstein approach to the problem by Lord Rayleigh, Bachelier, and Smoluchowski. In the second part, we detail the achievements of Perrin, measuring Avogadro's number, quantifying the experimental observations of Brownian movement, and introducing the problem of continuous curves without tangent, a precursor to fractal theory. The third part deals with modern application of Brownian movement, escape from a fixed optical trap, particle dynamics on a moving trap, and finally development of Brownian thermal ratchets. Finally, we give a short overview of bacteria motion, presented like an active Brownian movement with very high effective temperature.","PeriodicalId":7925,"journal":{"name":"Annual Review of Condensed Matter Physics","volume":" ","pages":""},"PeriodicalIF":22.6,"publicationDate":"2019-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/ANNUREV-CONMATPHYS-031218-013318","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46607039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-03-11DOI: 10.1146/ANNUREV-CONMATPHYS-031218-013554
U. Seifert
For a large class of nonequilibrium systems, thermodynamic notions like work, heat, and, in particular, entropy production can be identified on the level of fluctuating dynamical trajectories. Within stochastic thermodynamics various fluctuation theorems relating these quantities have been proven. Their application to experimental systems requires that all relevant mesostates are accessible. Recent advances address the typical situation that only partial, or coarse-grained, information about a system is available. Thermodynamic inference as a general strategy uses consistency constraints derived from stochastic thermodynamics to infer otherwise hidden properties of nonequilibrium systems. An important class in this respect are active particles, for which we resolve the conflicting strategies that have been proposed to identify entropy production. As a paradigm for thermodynamic inference, the thermodynamic uncertainty relation provides a lower bound on the entropy production through measurements of the dispersion of any current in the system. Likewise, it quantifies the cost of precision for biomolecular processes. Generalizations and ramifications allow the inference of, inter alia, model-free upper bounds on the efficiency of molecular motors and of the minimal number of intermediate states in enzymatic networks.
{"title":"From Stochastic Thermodynamics to Thermodynamic Inference","authors":"U. Seifert","doi":"10.1146/ANNUREV-CONMATPHYS-031218-013554","DOIUrl":"https://doi.org/10.1146/ANNUREV-CONMATPHYS-031218-013554","url":null,"abstract":"For a large class of nonequilibrium systems, thermodynamic notions like work, heat, and, in particular, entropy production can be identified on the level of fluctuating dynamical trajectories. Within stochastic thermodynamics various fluctuation theorems relating these quantities have been proven. Their application to experimental systems requires that all relevant mesostates are accessible. Recent advances address the typical situation that only partial, or coarse-grained, information about a system is available. Thermodynamic inference as a general strategy uses consistency constraints derived from stochastic thermodynamics to infer otherwise hidden properties of nonequilibrium systems. An important class in this respect are active particles, for which we resolve the conflicting strategies that have been proposed to identify entropy production. As a paradigm for thermodynamic inference, the thermodynamic uncertainty relation provides a lower bound on the entropy production through measurements of the dispersion of any current in the system. Likewise, it quantifies the cost of precision for biomolecular processes. Generalizations and ramifications allow the inference of, inter alia, model-free upper bounds on the efficiency of molecular motors and of the minimal number of intermediate states in enzymatic networks.","PeriodicalId":7925,"journal":{"name":"Annual Review of Condensed Matter Physics","volume":" ","pages":""},"PeriodicalIF":22.6,"publicationDate":"2019-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/ANNUREV-CONMATPHYS-031218-013554","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44375600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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