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Towards the safer use of warfarin II: Results of a workshop 迈向华法林的安全使用II:研讨会的结果
Pub Date : 2002-02-28 DOI: 10.1046/j.1440-1762.1999.00298.x
PJ Halstead BPharm, MPS, EE Roughead BPharm, MAppSc, K Rigby RN, BEc, MSc(Med), MSc(Hlth Econ), RB Clark BSc, MPH, AS Gallus MB BS, FRCPA, FRACP, FRCP(C)

Abstract The use of oral anticoagulation therapy (ACT) is expanding. Due to the combination of the narrow therapeutic range and relatively unpredictable pharmacokinetics and pharmacodynamics, there are relatively high risks involved in using this treatment. The purpose of this paper is to present the results of a focus group’s canvassing of ways to improve the management of the use of oral anticoagulants. Recommendations proposed include: (i) better patient selection; (ii) more patient involvement and research into the appropriateness of the current use of ACT in Australia; (iii) increased production, dissemination and implementation of ACT guidelines; (iv) assessment of home and practice ACT monitoring; and (v) research into the effectiveness of academic detailing and the use of management plans by dedicated ACT educators.

口服抗凝治疗(ACT)的应用正在扩大。由于治疗范围窄,药代动力学和药效学相对不可预测,因此使用该治疗具有较高的风险。本文的目的是介绍焦点小组对改善口服抗凝剂使用管理的方法的调查结果。建议包括:(i)更好地选择患者;(ii)对澳大利亚目前使用ACT的适当性进行更多的患者参与和研究;(iii)加强对acts准则的编制、传播和实施;(iv)评估家庭和实践ACT监测;(v)由专门的ACT教育工作者对学术细节和管理计划使用的有效性进行研究。
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引用次数: 9
Towards safer drug use in general practice 在一般实践中更安全地使用药物
Pub Date : 2002-02-28 DOI: 10.1046/j.1440-1762.1999.00302.x
ID Steven MD, MPH, FRACGP, A Malpass BHSc(Hons), J Moller BA, BSocAdmin, MPolAdmin, WB Runciman MBBCh, FANZCA, FFICANZCA, FRCA, FHKCA, PhD, SC Helps MSc, PhD

Abstract A voluntary, anonymous incident-monitoring study was set up to identify and characterize events or circumstances which could have or did harm a patient in general practice. The study included 673 practitioners who made 2582 reports, of which half (n = 1294) involved medication problems. Amongst these reports, 1556 adverse drug events (ADE) were identified. More common in general practice than in hospitals were problems with therapeutic use (26% vs. 8%), and prescribing of contraindicated medications (15% vs. 5%). In the latter group, 64 reports (4%) involved the prescription of a medication to which the patient was known to be allergic, 66 (4%) involved medication for which there was a recognized potential for a drug interaction, and 68 (4%) involved contraindicated medications due to pathophysiological factors. It was estimated that computer-based prescribing with decision support could eliminate at least a third of these problems in general practice. Further studies are needed to develop this and other preventive strategies.

摘要:一项自愿的、匿名的事件监测研究旨在识别和描述在一般实践中可能伤害或确实伤害患者的事件或情况。该研究包括673名从业人员,他们提交了2582份报告,其中一半(n = 1294)涉及药物问题。在这些报告中,确定了1556例药物不良事件(ADE)。在全科诊所比在医院更常见的是治疗使用问题(26%对8%)和处方禁忌症药物(15%对5%)。在后一组中,64例(4%)报告涉及患者已知过敏的药物处方,66例(4%)涉及已知可能发生药物相互作用的药物,68例(4%)涉及由于病理生理因素而禁忌的药物。据估计,有决策支持的计算机处方可以在一般实践中消除至少三分之一的这些问题。需要进一步的研究来制定这一战略和其他预防战略。
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引用次数: 31
Towards the safer use of non-steroidal anti-inflammatory drugs 更安全的使用非甾体抗炎药
Pub Date : 2002-02-28 DOI: 10.1046/j.1440-1762.1999.00287.x
RO Day MD, FRACP, D Rowett BPharm, EE Roughead BPharm, MAppSc

Abstract Musculoskeletal conditions afflict most of us at some time in our lives, and we all have relatives and friends who suffer the pain and disability sometimes associated with conditions such as back or neck pain, fibrositis and osteoarthritis. The goal of those of us who try to help individuals with these conditions is to achieve effective, but also safe, management of their musculoskeletal disorders, the commonest symptom of which is pain. This goal can be achieved by better diagnosis and problem formulation (allowing better selection of treatment options); informed selection of non-drug and drug therapeutic options, based on relative cost-benefit considerations; and the judicious, appropriate and safe use of drugs, particularly non-steroidal anti-inflammatory drugs (NSAID). Setting realistic goals and maintaining regular surveillance of patients are also important considerations. Finally, the active involvement of the patient in their own management is associated with better and safer outcomes.

肌肉骨骼疾病在我们生活中的某些时候折磨着我们大多数人,我们都有亲戚和朋友遭受疼痛和残疾,有时与背部或颈部疼痛、纤维性炎和骨关节炎有关。我们这些试图帮助患有这些疾病的人的目标是实现有效而又安全的管理他们的肌肉骨骼疾病,最常见的症状是疼痛。这一目标可以通过更好的诊断和问题制定(允许更好地选择治疗方案)来实现;根据相对成本效益考虑,在知情的情况下选择非药物和药物治疗方案;以及明智、适当和安全使用药物,特别是非甾体抗炎药(NSAID)。制定切合实际的目标和保持对患者的定期监测也是重要的考虑因素。最后,患者积极参与自己的管理与更好和更安全的结果相关。
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引用次数: 6
Patient perceived quality-of-care in hospital in the context of clinical pathways: Development of an approach 临床路径背景下患者感知的医院护理质量:一种方法的发展
Pub Date : 2002-02-28 DOI: 10.1046/j.1440-1762.1999.00307.x
S-C Chou DipNursing, BSocWk, BN, MN, RN, PhD candidate, D Boldy CertEd, BSc(Hons), MSc, PhD, FCHSE

Abstract Clinical pathways have been introduced in many hospitals with the aims of improving efficiency, reducing costs, and improving the quality and outcomes of care. However, there is a shortage of research evidence regarding the extent to which they do in fact achieve such aims. This paper describes the development and testing of a patient-perceived quality-of-care questionnaire for use in relation to the assessment of clinical pathways. Issues of validity and reliability are addressed and illustrative examples of results for two pilot hospitals are presented.

临床路径已经在许多医院引入,目的是提高效率,降低成本,提高护理质量和结果。然而,关于它们实际上在多大程度上实现了这些目标,缺乏研究证据。这篇论文描述了开发和测试的病人感知的质量的护理问卷用于相关的评估临床途径。讨论了有效性和可靠性问题,并给出了两家试点医院的结果示例。
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引用次数: 14
Beyond evidence-based guidelines to implementation: A model for integrating care for people with diabetes 从循证指南到实施:糖尿病患者综合护理模式
Pub Date : 2002-02-28 DOI: 10.1046/j.1440-1762.1999.00292.x
Sc Boyages FRACP, FAFPHM, J Sheridan RN, MMge, G Close MB, BS, MPH

Abstract There is a growing realization in the health system that integration of effort may be the best way of ensuring optimal outcomes of management both for clinicians and for people using the health system. It is also hypothesized that the impact of diabetes (chronic disease) and its sequelae could be reduced by the provision of well-organized care, based on agreed evidence-based guidelines for best practice, incorporating patient education and early detection of complication. This paper defines the characteristics of an integrated model of providing care to people with diabetes.

在卫生系统中,越来越多的人认识到,整合努力可能是确保临床医生和使用卫生系统的人获得最佳管理结果的最佳方式。还有一种假设是,根据商定的循证最佳做法指南,结合患者教育和早期发现并发症,提供组织良好的护理,可以减少糖尿病(慢性疾病)及其后遗症的影响。本文定义了为糖尿病患者提供护理的综合模式的特点。
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引用次数: 4
The characteristics of asthma education programs within New South Wales 新南威尔士州哮喘教育项目的特点
Pub Date : 2002-02-28 DOI: 10.1046/j.1440-1762.1999.00310.x
V Mcdonald RN, Dip Health Science (Nursing), R Toneguzzi RN, P Pratt, C Kessell RN, RM,BA, Health Sci (Nursing), J Hazell BA, Dip Ed, RN, P Gibson MBBS, FRACP

Abstract The aim of the study was to examine the characteristics of asthma education programs within NSW. A cross-sectional questionnaire survey concerning the aims and characteristics of 42 asthma education programs was administered to members of the Asthma Educators Association (AEA) of NSW. While most programs sought to improve asthma knowledge (78%), only a small number sought to improve asthma management skills (38%), asthma control (33%) and attitudes (10%). Most programs performed one-to-one (69%) education. Medical intervention was under-utilized by most programs and only 4% gave feedback to the referring doctor. Program evaluation was incompletely linked to program aims. There was incomplete evaluation of knowledge gain as an outcome. The study reviewed the characteristics of education programs within NSW. Existing programs appropriately employ a variety of educational methods and target a broad range of people with asthma. There remains a need to use a combined approach utilizing education and medical management, and to employ methods to evaluate programs.

摘要本研究的目的是研究新南威尔士州哮喘教育项目的特点。对新南威尔士州哮喘教育者协会(AEA)的成员进行了一项关于42个哮喘教育项目的目标和特点的横断面问卷调查。虽然大多数项目旨在提高哮喘知识(78%),但只有少数项目旨在提高哮喘管理技能(38%)、哮喘控制(33%)和态度(10%)。大多数项目实行一对一(69%)教育。大多数项目没有充分利用医疗干预,只有4%的项目向转诊医生提供了反馈。项目评估与项目目标没有完全联系起来。对知识获得作为结果的评估不完整。该研究回顾了新南威尔士州教育项目的特点。现有的项目适当地采用各种教育方法,并针对广泛的哮喘患者。仍然需要采用综合的方法,利用教育和医疗管理,并采用方法来评估方案。
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引用次数: 6
Incident monitoring in psychiatry 精神病学事件监测
Pub Date : 2002-02-28 DOI: 10.1046/j.1440-1762.1998.00278.x
M WRIGHT MB, BS, FRANZCP, G PARKER MB, BS, MD, PhD, FRANZCP

Critical Incident Monitoring (CIM) as an instrument of quality assurance (QA) has received increasing attention in recent years. The present study was developed to explore a potential role for CIM in QA for clinical psychiatry. A questionnaire was sent to psychiatrists and requested retrospective reporting of clinical incidents, and a pilot study of an inpatient-based incident reporting system was performed. All Fellows of the Royal Australian and New Zealand College of Psychiatry (RANZCP) were sent a questionnaire. Eight psychiatric inpatient services were invited to participate in the pilot study. The returns of the questionnaires were aggregated and analysed to reveal a relatively small number of separate incident types, with little difference between the ‘adverse outcome’ and ‘near-miss’ categories. Similar results were found with the pilot study. It was concluded that the development of a unified incident reporting system for use by psychiatric clinicians and psychiatric services may add usefully to existing quality improvement processes.

关键事件监测(CIM)作为质量保证(QA)的一种手段,近年来受到越来越多的关注。本研究旨在探讨CIM在临床精神病学QA中的潜在作用。向精神科医生发送了一份调查问卷,要求对临床事件进行回顾性报告,并对基于住院患者的事件报告系统进行了试点研究。澳大利亚和新西兰皇家精神病学学院(RANZCP)的所有研究员都收到了一份调查问卷。八家精神科住院服务机构被邀请参与这项试点研究。对问卷的反馈进行汇总和分析,以揭示相对较少的独立事件类型,“不良结果”和“险些”类别之间的差异不大。初步研究也发现了类似的结果。结论是,发展一个统一的事件报告系统,供精神科医生和精神科服务使用,可以有效地增加现有的质量改进过程。
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引用次数: 15
The impact of new technology on cholecystectomy rates in New South Wales 新技术对新南威尔士州胆囊切除术率的影响
Pub Date : 2002-02-28 DOI: 10.1046/j.1440-1762.1998.00282.x
MI ROB BSc, MA, CSTAT, P CORBEN MAppSc(OR), RL RUSHWORTH MB, BS(Hons), PhD, FAFPHM

This study examined the impact of the introduction of laparoscopic cholecystectomy (LC) on the rate and pattern of cholecystectomy in New South Wales, Australia. An analysis of the hospital data for the period 1981–94/95 was performed, which encompassed patients of both public and private hospitals. Cholecystectomy rates in the years after the introduction of LC in mid-1990 were 24% higher on average than rates in the prior years and rose from an average 1.68–2.09 per 1000. In the 5-year period of the study after the introduction of LC, the average age of private hospital patients increased from 50.6 to 53.4·years, while that of public hospital patients declined slightly from 53.5 to 52.4·years. Laparoscopic cholecystectomy was introduced more rapidly in private than public hospitals. By June 1995, 96% of private compared with 71% of public hospitals had introduced LC, and cholecystectomy patients in private hospitals were more likely to have laparoscopic surgery than patients in public hospitals (92% compared with 80%). The introduction of LC has been accompanied by a marked and sustained increase in the cholecystectomy rate. While the unit cost for the laparoscopic procedure is lower because of a shorter length of stay, the increase in the number of procedures means that there have been no net savings for the health system from the increased efficiency. While the new procedure offers superior advantages to patients with symptomatic gallbladder disease, the effect of the apparent lower threshold for surgery needs investigation.

本研究探讨了在澳大利亚新南威尔士州引入腹腔镜胆囊切除术(LC)对胆囊切除术的发生率和模式的影响。对1981-94/95年期间的医院数据进行了分析,其中包括公立和私立医院的病人。在1990年年中引入胆囊切除术后,胆囊切除术的发生率比前几年平均高24%,由平均每千人1.68-2.09例上升。在LC引入后的5年研究期间,私立医院患者的平均年龄从50.6岁上升到53.4·岁,而公立医院患者的平均年龄从53.5岁略微下降到52.4·岁。腹腔镜胆囊切除术在私立医院的推广速度要快于公立医院。到1995年6月,96%的私立医院和71%的公立医院引进了腹腔镜手术,私立医院的胆囊切除术患者比公立医院的患者更有可能进行腹腔镜手术(92%和80%)。LC的引入伴随着胆囊切除术率的显著和持续的增加。虽然由于住院时间较短,腹腔镜手术的单位成本较低,但手术数量的增加意味着卫生系统并没有从效率的提高中获得净节省。虽然新手术为有症状的胆囊疾病患者提供了优越的优势,但明显降低手术阈值的影响还需要研究。
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引用次数: 9
Functional status and health service planning 功能状态和健康服务规划
Pub Date : 2002-02-28 DOI: 10.1046/j.1440-1762.1999.00309.x
L Snow MSc, BSc(Hons), M Walker MBBS(Syd), FRACGP, Dip RACOG, Dip Paed (UNSW), M Ahern MHP, BA, RN, E O’Brien MHP, BN, Dc Saltman MD, BS, FRACGP, FAFPHM

Abstract Functional status indicators have been proposed as instruments to aid health service planning for patients. This study examines functional status at three points surrounding an acute health episode: admission, discharge and 3 months post discharge from a community hospital. The aim of the study is to determine the most appropriate time to measure functional status to assist health service planning. A longitudinal cohort study was conducted at Manly Hospital, Australia. Four hundred patients aged 65 years and over representing a 10% random sample of all hospital admissions in a 10-month period were interviewed on admission, discharge and 3 months post discharge. Repeated measure multiple analysis of variance identified a decline in functional status between admission and discharge. At 3 months post discharge functional status had improved to levels higher than admission. Functional status assessment at discharge can assist consumers, clinicians, health planners and health insurers to make effective decisions to maximize health outcomes.

功能状态指标已被提出作为辅助医疗服务计划的工具。本研究考察了急性健康事件的三个时点的功能状态:入院、出院和出院后3个月。该研究的目的是确定最合适的时间来测量功能状态,以协助卫生服务计划。在澳大利亚曼利医院进行了一项纵向队列研究。在入院、出院和出院后3个月对400名65岁及以上的患者进行了访谈,这些患者代表了10个月内所有住院患者的10%随机样本。重复测量多重方差分析确定了入院和出院期间功能状态的下降。出院后3个月,功能状况改善至高于入院水平。出院时的功能状态评估可以帮助消费者、临床医生、健康规划师和健康保险公司做出有效的决策,以最大限度地提高健康结果。
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引用次数: 2
Suspected infection in children with cancer 癌症患儿疑似感染
Pub Date : 2002-02-28 DOI: 10.1046/j.1440-1762.1998.00284.x
PD JONES MB, BS, DCH, FRACP, RL HENRY HENRY MD, FRACP, J STUART STUART MB, BS, FRACP, MMED Sci, L FRANCIS FRANCIS BA, MMED STAT

The microbiology and severity of suspected infections in children with cancer admitted to the John Hunter Children’s Hospital was determined in order to assess whether any alteration to the infection treatment protocol was required. All children with cancer aged 1–17 years who had an episode of suspected or proven infection that required parenteral treatment at John Hunter Children’s Hospital (JHCH) during 1994/95 were reviewed. Thirty-seven children were treated for cancer at JHCH; 62 admissions for suspected infection which involved 26 children were reviewed. Sixteen of these children had a permanent central line. Children with a central line had an increase in the number of days of inpatient treatment required for the treatment of suspected infection, and they had more episodes of infection. A pathogen was isolated more frequently with blood cultures being positive more often and Gram- positive species were methicillin resistant more often. These differences were not statistically significant. A pathogen was isolated in 52% of admissions. Sixteen pathogens were Gram positive; 12 were Gram negative, two were fungal and two were viral. Blood cultures were positive in 21 of 62 admissions, skin swabs in four admissions, urine cultures in three admissions, stool in two admissions and one species was isolated from an epidural catheter tip and from the sputum. In 16% of admissions, the identified organism was resistant to the initial empirical therapy of tobramycin and piperacillin. In a further 13%, flucloxacillin was added to the empirical regimen when a sensitive Staphylococcus was identified. No significant differences between the culture-negative and culture-positive groups were observed in admission pulse, fever or admission neutrophil count. However, those patients with a central line had a higher incidence of having a pathogen isolated if their temperature was > 39.5°C. The median length of stay was longer for patients with a pathogen isolated on blood culture. Admission blood cultures were positive in 53% of admissions with an initial neutrophil count > 1000 × 109/mL. Each of these children had a central line. Only one child died of infection during the 2-year study period. This review supports the observations that Gram-positive infection is now more common than Gram-negative infection in children with cancer. Despite the management advantages a permanent central line affords it is clear those children with a central line have an increased rate of infection and there needs to be caution in their use. The most important is the observation that any fever > 39.5°C in a child with a central line is likely to be associated with a documented infection irrespective of the neutrophil count. The clinical outcomes observed in the present study indicate that tobramycin and piperacillin are effective empirical treatments for suspected infection in children with cancer.

对约翰·亨特儿童医院收治的癌症患儿的微生物学和疑似感染的严重程度进行了测定,以评估是否需要对感染治疗方案进行任何修改。对1994/95年期间在约翰·亨特儿童医院(JHCH)发生过疑似或证实感染并需要肠外治疗的所有1-17岁癌症儿童进行了审查。37名儿童在JHCH接受癌症治疗;对62例疑似感染住院病例进行了审查,涉及26名儿童。其中16个孩子有永久性中央静脉导管。有中心静脉管的儿童因疑似感染而需要住院治疗的天数增加,并且他们有更多的感染发作。病原菌被分离的频率更高,血培养阳性的频率更高,革兰氏阳性的菌种对甲氧西林耐药的频率更高。这些差异没有统计学意义。在52%的入院患者中分离出病原体。革兰氏阳性16例;革兰氏阴性12例,真菌2例,病毒2例。62例患者中有21例血培养阳性,4例皮肤拭子阳性,3例尿培养阳性,2例粪便培养阳性,从硬膜外导管尖端和痰中分离出1种。在16%的入院患者中,鉴定出的微生物对妥布霉素和哌拉西林的初始经验性治疗具有耐药性。在另外13%的病例中,当发现敏感葡萄球菌时,在经验方案中加入氟氯西林。培养阴性组与培养阳性组入院脉搏、发热、入院中性粒细胞计数均无显著差异。然而,那些有中央静脉管的病人,如果他们的体温是>39.5°C。血培养分离出病原体的患者中位住院时间更长。入院时血液培养阳性的患者占入院时中性粒细胞计数的53%;1000 × 109/mL。每个孩子都有中心静脉导管。在两年的研究期间,只有一名儿童死于感染。本综述支持革兰氏阳性感染现在比革兰氏阴性感染在癌症儿童中更常见的观察结果。尽管永久性中心静脉管提供了管理优势,但很明显,使用中心静脉管的儿童感染率增加,使用时需要谨慎。最重要的是要注意任何发烧。无论中性粒细胞计数如何,有中心静脉管的儿童的39.5°C可能与记录的感染有关。本研究观察到的临床结果表明妥布霉素和哌拉西林是治疗癌症患儿疑似感染的有效经验疗法。
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引用次数: 10
期刊
Journal of quality in clinical practice
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