Pub Date : 2000-02-01DOI: 10.1016/S1461-5347(99)00238-2
Vinod D Vilivalam, Lisbeth Illum, Khurshid Iqbal
Manufactured by the process of injection moulding, starch capsules have been shown to be a very useful alternative delivery system for orally administered compounds. This review describes the starch capsule manufacturing and filling processes and provides an overview of the capsules’ physical characteristics. In addition, investigations supporting the development of novel delivery technologies based on the starch capsules are described. Particular emphasis is given to a technology that facilitates drug delivery to specific sites in the human gastrointestinal tract.
{"title":"Starch capsules: an alternative system for oral drug delivery","authors":"Vinod D Vilivalam, Lisbeth Illum, Khurshid Iqbal","doi":"10.1016/S1461-5347(99)00238-2","DOIUrl":"10.1016/S1461-5347(99)00238-2","url":null,"abstract":"<div><p>Manufactured by the process of injection moulding, starch capsules have been shown to be a very useful alternative delivery system for orally administered compounds. This review describes the starch capsule manufacturing and filling processes and provides an overview of the capsules’ physical characteristics. In addition, investigations supporting the development of novel delivery technologies based on the starch capsules are described. Particular emphasis is given to a technology that facilitates drug delivery to specific sites in the human gastrointestinal tract.</p></div>","PeriodicalId":80125,"journal":{"name":"Pharmaceutical science & technology today","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2000-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1461-5347(99)00238-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21518893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Part one of this two-part review described the advantages and limitations of quantitative structure–property relationships (QSPR), and offered an overview of the components involved in the development of correlations1. Part two provides a discussion of a few notable examples of relationships with organoleptic, physicochemical and pharmaceutical properties.
{"title":"Quantitative structure–property relationships in pharmaceutical research – Part 2","authors":"Manish Grover , Bhupinder Singh , Monika Bakshi , Saranjit Singh","doi":"10.1016/S1461-5347(99)00215-1","DOIUrl":"10.1016/S1461-5347(99)00215-1","url":null,"abstract":"<div><p>Part one of this two-part review described the advantages and limitations of quantitative structure–property relationships (QSPR), and offered an overview of the components involved in the development of correlations<span><sup>1</sup></span>. Part two provides a discussion of a few notable examples of relationships with organoleptic, physicochemical and pharmaceutical properties.</p></div>","PeriodicalId":80125,"journal":{"name":"Pharmaceutical science & technology today","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2000-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1461-5347(99)00215-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21518891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2000-02-01DOI: 10.1016/S1461-5347(99)00239-4
Andrew W Lloyd (Monitor Editor), A.Christy Hunter (Monitor Editor)
Monitor provides an insight into the latest developments in pharmaceutical science and technology through brief synopses of recent presentations, publications and patents, and expert commentaries on the latest technologies. There are two sections: Progress summarizes the latest developments in pharmaceutical process technology, formulation, analytical technology, sterilization, controlled drug delivery systems and regulatory issues; Profiles offers expert commentary on emerging technologies, novel processes and strategic, organizational and logistic issues underlying pharmaceutical R&D.
{"title":"Monitor: progress and profiles","authors":"Andrew W Lloyd (Monitor Editor), A.Christy Hunter (Monitor Editor)","doi":"10.1016/S1461-5347(99)00239-4","DOIUrl":"10.1016/S1461-5347(99)00239-4","url":null,"abstract":"<div><p><em>Monitor</em> provides an insight into the latest developments in pharmaceutical science and technology through brief synopses of recent presentations, publications and patents, and expert commentaries on the latest technologies. There are two sections: <em>Progress</em> summarizes the latest developments in pharmaceutical process technology, formulation, analytical technology, sterilization, controlled drug delivery systems and regulatory issues; <em>Profiles</em> offers expert commentary on emerging technologies, novel processes and strategic, organizational and logistic issues underlying pharmaceutical R&D.</p></div>","PeriodicalId":80125,"journal":{"name":"Pharmaceutical science & technology today","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2000-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1461-5347(99)00239-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21518894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2000-02-01DOI: 10.1016/S1461-5347(99)00237-0
Mira Jivraj , Luigi G. Martini , Carol M. Thomson
The humble tablet dosage form still accounts for more than 80% of all dosage forms administered to man. This review will outline the various excipients that have been used as fillers in direct compression formulations, with particular emphasis on what is expected from such excipients in terms of their functionality. It is intended that this overview (which is by no means exhaustive) will serve as an ‘aide-memoire’ to the formulation scientist.
{"title":"An overview of the different excipients useful for the direct compression of tablets","authors":"Mira Jivraj , Luigi G. Martini , Carol M. Thomson","doi":"10.1016/S1461-5347(99)00237-0","DOIUrl":"10.1016/S1461-5347(99)00237-0","url":null,"abstract":"<div><p>The humble tablet dosage form still accounts for more than 80% of all dosage forms administered to man. This review will outline the various excipients that have been used as fillers in direct compression formulations, with particular emphasis on what is expected from such excipients in terms of their functionality. It is intended that this overview (which is by no means exhaustive) will serve as an ‘aide-memoire’ to the formulation scientist.</p></div>","PeriodicalId":80125,"journal":{"name":"Pharmaceutical science & technology today","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2000-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1461-5347(99)00237-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21518892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2000-01-01DOI: 10.1016/S1461-5347(99)00232-1
Stephen A Arlington (Head of Pharmaceutical Research and Development Consulting)
{"title":"How to survive in tomorrow’s healthcare market","authors":"Stephen A Arlington (Head of Pharmaceutical Research and Development Consulting)","doi":"10.1016/S1461-5347(99)00232-1","DOIUrl":"10.1016/S1461-5347(99)00232-1","url":null,"abstract":"","PeriodicalId":80125,"journal":{"name":"Pharmaceutical science & technology today","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2000-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1461-5347(99)00232-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21493122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2000-01-01DOI: 10.1016/S1461-5347(99)00227-8
Mark A. Phipps , Lesley A. Mackin
Microcalorimetry is an analytical technique that has found numerous applications within the pharmaceutical environment. In the realm of pharmaceutics, especially solid state pharmaceutics, the technique has proved to be an invaluable tool. This review addresses the solid state applications of microcalorimetry within the pharmaceutical industry, with a specific focus on stability, compatibility and amorphicity determinations.
{"title":"Application of isothermal microcalorimetry in solid state drug development","authors":"Mark A. Phipps , Lesley A. Mackin","doi":"10.1016/S1461-5347(99)00227-8","DOIUrl":"10.1016/S1461-5347(99)00227-8","url":null,"abstract":"<div><p>Microcalorimetry is an analytical technique that has found numerous applications within the pharmaceutical environment. In the realm of pharmaceutics, especially solid state pharmaceutics, the technique has proved to be an invaluable tool. This review addresses the solid state applications of microcalorimetry within the pharmaceutical industry, with a specific focus on stability, compatibility and amorphicity determinations.</p></div>","PeriodicalId":80125,"journal":{"name":"Pharmaceutical science & technology today","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2000-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1461-5347(99)00227-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21493126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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