首页 > 最新文献

APIK Journal of Internal Medicine最新文献

英文 中文
Study of Correlation between Right Ventricular Ejection Fraction with Left Ventricular Ejection Fraction in Patients of Chronic Heart Failure with Diabetes, using Two-dimensional Echocardiography 二维超声心动图研究糖尿病慢性心力衰竭患者右室射血分数与左室射血分的相关性
Pub Date : 2023-08-22 DOI: 10.4103/ajim.ajim_5_23
Vandan Shah, S. Mane, R. Khyalappa
Diabetes is one of the most significant health issues. Patients with type 2 diabetes mellitus (DM) are more susceptible to an elevated cardiovascular risk, including heart failure. Echocardiography should help in the early identification of these myocardial abnormalities that would help properly treat these individuals. The study was conducted over 18 months and focused on patients with diabetes and chronic heart failure who met inclusion and exclusion criteria. Ethical approval was obtained, and all patients provided their consent to participate in the study. The participants underwent a two-dimensional echocardiogram to assess their heart function, and relevant laboratory tests, imaging results, and information about medications received during their hospitalization were recorded. As per The New British Society of Echocardiography criteria, 64 patients had impaired left ventricular ejection fraction (LVEF), and 31 had severely impaired LVEF. The majority of the patients with impaired LVEF, 53%, also had impaired right ventricular ejection fraction (RVEF). Of 31 patients with severely impaired LVEF, 58% also had severely impaired RVEF. The association between LVEF and RVEF is statistically significant (P < 0.05). There is a positive correlation between LVEF (%) and RVEF (%), which was statistically significant (P < 0.05). Severe dysfunction in LVEF is also present in patients with severe dysfunction of RVEF. The majority of patients who had reduced LVEF also had reduced RVEF, and this association was significant. While there was a correlation between glycosylated hemoglobin levels and both LVEF and RVEF, it was not statistically significant. Hence, patients who are identified to have lower LVEF should also be evaluated for RVEF.
糖尿病是最重要的健康问题之一。2型糖尿病(DM)患者更容易患心血管疾病,包括心力衰竭。超声心动图应该有助于早期识别这些心肌异常,这将有助于正确治疗这些个体。该研究进行了18个月,重点关注符合纳入和排除标准的糖尿病和慢性心力衰竭患者。获得了伦理批准,所有患者都同意参与研究。参与者接受了二维超声心动图来评估他们的心脏功能,并记录了相关的实验室检查、成像结果和住院期间接受的药物信息。根据新英国超声心动图学会标准,64例患者左室射血分数(LVEF)受损,31例患者左室射血分数严重受损。大多数LVEF受损的患者(53%)也有右心室射血分数(RVEF)受损。在31例LVEF严重受损的患者中,58%的患者RVEF也严重受损。LVEF与RVEF的相关性有统计学意义(P < 0.05)。LVEF(%)与RVEF(%)呈正相关,差异有统计学意义(P < 0.05)。严重的左心室功能障碍也存在于严重的右心室功能障碍患者中。大多数LVEF降低的患者也有RVEF降低,这种关联是显著的。虽然糖化血红蛋白水平与LVEF和RVEF之间存在相关性,但无统计学意义。因此,对于LVEF较低的患者也应进行RVEF评估。
{"title":"Study of Correlation between Right Ventricular Ejection Fraction with Left Ventricular Ejection Fraction in Patients of Chronic Heart Failure with Diabetes, using Two-dimensional Echocardiography","authors":"Vandan Shah, S. Mane, R. Khyalappa","doi":"10.4103/ajim.ajim_5_23","DOIUrl":"https://doi.org/10.4103/ajim.ajim_5_23","url":null,"abstract":"\u0000 \u0000 \u0000 Diabetes is one of the most significant health issues. Patients with type 2 diabetes mellitus (DM) are more susceptible to an elevated cardiovascular risk, including heart failure. Echocardiography should help in the early identification of these myocardial abnormalities that would help properly treat these individuals.\u0000 \u0000 \u0000 \u0000 The study was conducted over 18 months and focused on patients with diabetes and chronic heart failure who met inclusion and exclusion criteria. Ethical approval was obtained, and all patients provided their consent to participate in the study. The participants underwent a two-dimensional echocardiogram to assess their heart function, and relevant laboratory tests, imaging results, and information about medications received during their hospitalization were recorded.\u0000 \u0000 \u0000 \u0000 As per The New British Society of Echocardiography criteria, 64 patients had impaired left ventricular ejection fraction (LVEF), and 31 had severely impaired LVEF. The majority of the patients with impaired LVEF, 53%, also had impaired right ventricular ejection fraction (RVEF). Of 31 patients with severely impaired LVEF, 58% also had severely impaired RVEF. The association between LVEF and RVEF is statistically significant (P < 0.05). There is a positive correlation between LVEF (%) and RVEF (%), which was statistically significant (P < 0.05). Severe dysfunction in LVEF is also present in patients with severe dysfunction of RVEF.\u0000 \u0000 \u0000 \u0000 The majority of patients who had reduced LVEF also had reduced RVEF, and this association was significant. While there was a correlation between glycosylated hemoglobin levels and both LVEF and RVEF, it was not statistically significant. Hence, patients who are identified to have lower LVEF should also be evaluated for RVEF.\u0000","PeriodicalId":8012,"journal":{"name":"APIK Journal of Internal Medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46728369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A prospective study to determine the incidence, clinical profile, and outcomes of patients with ventilator-associated pneumonia 一项确定呼吸机相关肺炎患者发病率、临床特征和预后的前瞻性研究
Pub Date : 2023-07-01 DOI: 10.4103/ajim.ajim_95_22
Sagnik Bhattacharjee, A. Khyriem, C. Lyngdoh, A. Prasad
Objective: The objective was to determine the incidence, etiological agents, and antibiotic susceptibility pattern of isolates causing ventilator-associated pneumonia (VAP). Methods: The prospective observational study was carried out on 146 adults admitted to the hospital, who were put on mechanical ventilation for a minimum period of 48 h at NEIGRIHMS, Shillong. The study was conducted for 1 year from December 2019 to December 2020. VAP was diagnosed as per the Clinical Pulmonary Infection Score. Demographic, clinical characteristics, culture reports, and antibiotic susceptibility of the patients were noted. Patients were followed up till discharge or death. Outcome measures were risk factors for VAP and mortality. Results: We report an incidence of VAP as 10.6/1000 ventilator days. The predominant organisms seen were Acinetobacter baumannii (62.33%), Klebsiella pneumoniae (47.26%), and Pseudomonas aeruginosa (19.18%). 33/146 (22.6%) patients expired, among which 17 patients had VAP (40.48% vs. 15.38%, P = 0.001). VAP patients had significantly higher odds of smoking (odds ratio [OR] = 2.412, P = 0.016), more polybacterial infections (OR = 2.271, P = 0.024), and more mortality (OR = 3.681, P = 0.001). Among the organisms, P. aeruginosa (OR = 0.115, P = 0.013) and K. pneumoniae (OR = 6.818, P = 0.003) were significantly associated with mortality in patients with VAP. Conclusion: We report an incidence of VAP as 10.6/1000 ventilator days among intensive care unit patients. Smoking was a significant risk factor for VAP. VAP patients had a significantly higher risk of mortality with K. pneumoniae and P. aeruginosa being significant organisms responsible for it.
目的:确定引起呼吸机相关性肺炎(VAP)的分离株的发病率、病原学和抗生素敏感性模式。方法:对146名入院的成年人进行前瞻性观察研究,他们在Shillong的NEIGRIHMS接受了至少48小时的机械通气。该研究为期1年,从2019年12月至2020年12月。VAP根据临床肺部感染评分进行诊断。记录了患者的人口统计学、临床特征、培养报告和抗生素易感性。对患者进行随访,直至出院或死亡。结果指标是VAP和死亡率的危险因素。结果:我们报告VAP的发生率为10.6/1000呼吸机日。主要生物为鲍曼不动杆菌(62.33%)、肺炎克雷伯菌(47.26%)和铜绿假单胞菌(19.18%)。33/146(22.6%)患者过期,其中17名患者患有VAP(40.48%对15.38%,P=0.001)。VAP患者吸烟的几率显著更高(比值比[OR]=2.412,P=0.016),多菌感染的几率更多(OR=2.271,P=0.024),在生物体中,铜绿假单胞菌(OR=0.115,P=0.013)和肺炎克雷伯菌(OR=6.818,P=0.003)与VAP患者的死亡率显著相关。结论:我们报告重症监护病房患者VAP的发生率为10.6/1000呼吸机日。吸烟是VAP的重要危险因素。VAP患者的死亡率明显更高,肺炎克雷伯菌和铜绿假单胞菌是造成VAP的重要生物。
{"title":"A prospective study to determine the incidence, clinical profile, and outcomes of patients with ventilator-associated pneumonia","authors":"Sagnik Bhattacharjee, A. Khyriem, C. Lyngdoh, A. Prasad","doi":"10.4103/ajim.ajim_95_22","DOIUrl":"https://doi.org/10.4103/ajim.ajim_95_22","url":null,"abstract":"Objective: The objective was to determine the incidence, etiological agents, and antibiotic susceptibility pattern of isolates causing ventilator-associated pneumonia (VAP). Methods: The prospective observational study was carried out on 146 adults admitted to the hospital, who were put on mechanical ventilation for a minimum period of 48 h at NEIGRIHMS, Shillong. The study was conducted for 1 year from December 2019 to December 2020. VAP was diagnosed as per the Clinical Pulmonary Infection Score. Demographic, clinical characteristics, culture reports, and antibiotic susceptibility of the patients were noted. Patients were followed up till discharge or death. Outcome measures were risk factors for VAP and mortality. Results: We report an incidence of VAP as 10.6/1000 ventilator days. The predominant organisms seen were Acinetobacter baumannii (62.33%), Klebsiella pneumoniae (47.26%), and Pseudomonas aeruginosa (19.18%). 33/146 (22.6%) patients expired, among which 17 patients had VAP (40.48% vs. 15.38%, P = 0.001). VAP patients had significantly higher odds of smoking (odds ratio [OR] = 2.412, P = 0.016), more polybacterial infections (OR = 2.271, P = 0.024), and more mortality (OR = 3.681, P = 0.001). Among the organisms, P. aeruginosa (OR = 0.115, P = 0.013) and K. pneumoniae (OR = 6.818, P = 0.003) were significantly associated with mortality in patients with VAP. Conclusion: We report an incidence of VAP as 10.6/1000 ventilator days among intensive care unit patients. Smoking was a significant risk factor for VAP. VAP patients had a significantly higher risk of mortality with K. pneumoniae and P. aeruginosa being significant organisms responsible for it.","PeriodicalId":8012,"journal":{"name":"APIK Journal of Internal Medicine","volume":"11 1","pages":"179 - 184"},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41413041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Original antigenic sin in dengue - Hoskins effect 登革-霍斯金斯效应中的原始性抗原
Pub Date : 2023-07-01 DOI: 10.4103/ajim.ajim_96_21
V. Kamath, Nisha Olakkengi
Dengue is a mosquito-borne viral infection found in tropical and subtropical climates worldwide, mostly in urban and semiurban areas. The virus responsible for causing dengue is called dengue virus. There are four dengue virus serotypes, implying that it is possible to be infected four times. While many dengue virus infections produce only mild illness, occasionally, this develops into potentially lethal complications, called severe dengue, dengue hemorrhagic fever, and dengue shock syndrome. Currently, there is no specific treatment for dengue/severe dengue. Due to a rise in mortality rates associated with dengue hemorrhagic fever, severe dengue, and dengue shock syndrome, a better understanding of the reason behind dengue hemorrhagic fever is required. Hence, in this article, we further describe the original antigenic sin in dengue and how the occurrence of Hoskins effect is a major determinant factor for the progression to dengue hemorrhagic fever.
登革热是一种蚊子传播的病毒感染,在全球热带和亚热带气候中发现,主要发生在城市和半城市地区。引起登革热的病毒被称为登革热病毒。登革热病毒有四种血清型,这意味着它有可能被感染四次。虽然许多登革热病毒感染只会产生轻微的疾病,但偶尔会发展成潜在的致命并发症,称为严重登革热、登革热出血热和登革热休克综合征。目前,登革热/严重登革热尚无特效治疗方法。由于与登革热出血热、严重登革热和登革热休克综合征相关的死亡率上升,需要更好地了解登革热出血热背后的原因。因此,在这篇文章中,我们进一步描述了登革热的原始抗原sin,以及Hoskins效应的发生是如何成为进展为登革热出血热的主要决定因素。
{"title":"Original antigenic sin in dengue - Hoskins effect","authors":"V. Kamath, Nisha Olakkengi","doi":"10.4103/ajim.ajim_96_21","DOIUrl":"https://doi.org/10.4103/ajim.ajim_96_21","url":null,"abstract":"Dengue is a mosquito-borne viral infection found in tropical and subtropical climates worldwide, mostly in urban and semiurban areas. The virus responsible for causing dengue is called dengue virus. There are four dengue virus serotypes, implying that it is possible to be infected four times. While many dengue virus infections produce only mild illness, occasionally, this develops into potentially lethal complications, called severe dengue, dengue hemorrhagic fever, and dengue shock syndrome. Currently, there is no specific treatment for dengue/severe dengue. Due to a rise in mortality rates associated with dengue hemorrhagic fever, severe dengue, and dengue shock syndrome, a better understanding of the reason behind dengue hemorrhagic fever is required. Hence, in this article, we further describe the original antigenic sin in dengue and how the occurrence of Hoskins effect is a major determinant factor for the progression to dengue hemorrhagic fever.","PeriodicalId":8012,"journal":{"name":"APIK Journal of Internal Medicine","volume":"11 1","pages":"147 - 149"},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43793540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A study of electrolyte imbalance in Coronavirus Disease-2019 at a rural tertiary health care center 农村三级卫生保健中心2019冠状病毒病电解质失衡研究
Pub Date : 2023-07-01 DOI: 10.4103/ajim.ajim_113_22
R. Sheeba, Dinesh Vishwanathan, V. Kamath
Background: With the ongoing onslaught of coronavirus disease-2019 (COVID-19) pandemic, identifying factors predicting the disease course and outcome become immensely important. Although globally reported, a potential association between electrolyte disturbance and COVID-19 disease has not been well researched. Dyselectrolytemia not only impacts patient care but also provides insight into the pathophysiology of COVID-19. Aims and Objectives: Our aim was to study electrolyte disturbances among COVID-19 patients and its impact on the disease outcome. Materials and Methods: This was a retrospective observational study conducted in a total of 397 patients detected to have electrolyte abnormalities among 2914 adult inpatients, diagnosed with COVID 19 infection in a tertiary care center over a period of 10 months (July 2020–December 2020 and April 2021–July 2021). Results: A total of 2914 patients were diagnosed with COVID-19 of whom 397 (13.62%) patients were found to have an electrolyte imbalance. Hyponatremia (n = 199) 51% was the most common electrolyte disturbance followed by hypokalemia (n = 94) 24.3% and mixed electrolyte abnormality (n = 81) 20.4%. Electrolyte imbalance was directly related to the clinical outcome of the disease which was statistically significant P = 0.0001. Conclusion: Hyponatremia has a significant direct correlation with mortality in patients with COVID-19. However, hypokalemia, hyperkalemia, and hypernatremia also influence the disease outcome. We recommend that the estimation of electrolytes should be done routinely for all hospitalized patients with COVID-19 as it adds to the prognostication of these patients.
背景:随着2019冠状病毒病(新冠肺炎)大流行的持续冲击,识别预测疾病过程和结果的因素变得非常重要。尽管全球都有报道,但电解质紊乱与新冠肺炎疾病之间的潜在关联尚未得到很好的研究。电解质紊乱不仅影响患者护理,还提供了对新冠肺炎病理生理学的深入了解。目的和目的:我们的目的是研究新冠肺炎患者的电解质紊乱及其对疾病结果的影响。材料和方法:这是一项为期10个月(2020年7月至2020年12月和2021年4月至2021年7月)的回顾性观察性研究,共对2914名在三级护理中心诊断为新冠肺炎19型感染的成年住院患者中的397名电解质异常患者进行了研究。结果:共有2914名患者被诊断为新冠肺炎,其中397名(13.62%)患者出现电解质失衡。低钠血症(n=199)51%是最常见的电解质紊乱,其次是低钾血症(n=94)24.3%和混合电解质异常(n=81)20.4%。电解质失衡与疾病的临床结果直接相关,具有统计学意义P=0.0001。结论:新冠肺炎患者低钠血症与死亡率直接相关。然而,低钾血症、高钾血症和高钠血症也会影响疾病的预后。我们建议对所有新冠肺炎住院患者常规进行电解质评估,因为这会增加这些患者的预后。
{"title":"A study of electrolyte imbalance in Coronavirus Disease-2019 at a rural tertiary health care center","authors":"R. Sheeba, Dinesh Vishwanathan, V. Kamath","doi":"10.4103/ajim.ajim_113_22","DOIUrl":"https://doi.org/10.4103/ajim.ajim_113_22","url":null,"abstract":"Background: With the ongoing onslaught of coronavirus disease-2019 (COVID-19) pandemic, identifying factors predicting the disease course and outcome become immensely important. Although globally reported, a potential association between electrolyte disturbance and COVID-19 disease has not been well researched. Dyselectrolytemia not only impacts patient care but also provides insight into the pathophysiology of COVID-19. Aims and Objectives: Our aim was to study electrolyte disturbances among COVID-19 patients and its impact on the disease outcome. Materials and Methods: This was a retrospective observational study conducted in a total of 397 patients detected to have electrolyte abnormalities among 2914 adult inpatients, diagnosed with COVID 19 infection in a tertiary care center over a period of 10 months (July 2020–December 2020 and April 2021–July 2021). Results: A total of 2914 patients were diagnosed with COVID-19 of whom 397 (13.62%) patients were found to have an electrolyte imbalance. Hyponatremia (n = 199) 51% was the most common electrolyte disturbance followed by hypokalemia (n = 94) 24.3% and mixed electrolyte abnormality (n = 81) 20.4%. Electrolyte imbalance was directly related to the clinical outcome of the disease which was statistically significant P = 0.0001. Conclusion: Hyponatremia has a significant direct correlation with mortality in patients with COVID-19. However, hypokalemia, hyperkalemia, and hypernatremia also influence the disease outcome. We recommend that the estimation of electrolytes should be done routinely for all hospitalized patients with COVID-19 as it adds to the prognostication of these patients.","PeriodicalId":8012,"journal":{"name":"APIK Journal of Internal Medicine","volume":"11 1","pages":"185 - 190"},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42009717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Multisystem inflammatory syndrome in adults: Underdiagnosed?? 成人多系统炎症综合征:诊断不足??
Pub Date : 2023-07-01 DOI: 10.4103/ajim.ajim_72_21
Dilmo Yeldo, T. Ravindra, B. Arjun
Multisystem inflammatory syndrome (MIS) in adults is a rare diagnosis compared to its counterpart in children. There are standard guidelines for the managment of MIS in children, the lack of such standard guideline for adult patients makes it a diagnostic challenge. Furthermore, lack of awareness about MIS-A among treating doctors can result in the condition to go undiagnosed or misdiagnosed. Here, we are presenting a rare case of MIS in a 38-year-old female who presented to us with a history of fever and cervical lymphadenopathy.
与儿童的多系统炎症综合征相比,成人的多系统炎性综合征是一种罕见的诊断。儿童MIS的管理有标准指南,但成人患者缺乏此类标准指南使其成为诊断挑战。此外,治疗医生对MIS-A缺乏认识可能导致病情无法诊断或误诊。在这里,我们介绍了一个罕见的MIS病例,一位38岁的女性,她有发烧和颈部淋巴结病的病史。
{"title":"Multisystem inflammatory syndrome in adults: Underdiagnosed??","authors":"Dilmo Yeldo, T. Ravindra, B. Arjun","doi":"10.4103/ajim.ajim_72_21","DOIUrl":"https://doi.org/10.4103/ajim.ajim_72_21","url":null,"abstract":"Multisystem inflammatory syndrome (MIS) in adults is a rare diagnosis compared to its counterpart in children. There are standard guidelines for the managment of MIS in children, the lack of such standard guideline for adult patients makes it a diagnostic challenge. Furthermore, lack of awareness about MIS-A among treating doctors can result in the condition to go undiagnosed or misdiagnosed. Here, we are presenting a rare case of MIS in a 38-year-old female who presented to us with a history of fever and cervical lymphadenopathy.","PeriodicalId":8012,"journal":{"name":"APIK Journal of Internal Medicine","volume":"11 1","pages":"196 - 198"},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44953735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Deltacron: A new public health concern Deltacron:一个新的公共健康问题
Pub Date : 2023-07-01 DOI: 10.4103/ajim.ajim_154_22
P. Sookaromdee, V. Wiwanitkit
{"title":"Deltacron: A new public health concern","authors":"P. Sookaromdee, V. Wiwanitkit","doi":"10.4103/ajim.ajim_154_22","DOIUrl":"https://doi.org/10.4103/ajim.ajim_154_22","url":null,"abstract":"","PeriodicalId":8012,"journal":{"name":"APIK Journal of Internal Medicine","volume":"11 1","pages":"209 - 209"},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46740146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of In vitro activity of tigecycline against multidrug-resistant clinical isolates 替加环素对耐多药临床分离株的体外活性评价
Pub Date : 2023-07-01 DOI: 10.4103/ajim.ajim_53_22
Livya Wilson, T. Kuruvilla
Introduction: Multiple drug resistance (MDR) of the bacteria is an issue across any health-care setting worldwide. This leads to prolonged hospital stay and high cost of treatment. One must be cautious to use reserve drugs such as imipenem, meropenem, colistin, polymyxin, and tigecycline. Tigecycline is a mainstay to treat emerging single or MDR pathogens. The study was conducted to assess the in vitro sensitivity of tigecycline to MDR isolates and to compare the sensitivity of Kirby–Bauer (KB) disc-diffusion method with the Epsilometer (E-test) against various MDR clinical isolates. Materials and Methods: This prospective study was done from January 2019 to 2020 on MDR isolates from clinical specimens. The isolates were tested for their antibiotic sensitivity to tigecycline by KB and E-test method to know the minimum inhibitory concentration (MIC) of tigecycline. Statistical data were analyzed by the percentage method. Results: Tigecycline showed a higher in vitro sensitivity against multidrug-resistant isolates in our study. Among the 89 MDR isolates obtained, 38 (42.7) were found to be sensitive to tigecycline by the KB diffusion and 67 (75.3) were sensitive by the E-test method. Conclusions: Tigecycline is a reserve antibiotic against MDR organisms, especially useful to treat coinfections of Gram-positive and Gram-negative superbugs. The E-test was found to be far superior to the KB method to detect in vitro activity and the results of this test will guide the clinician to judiciously use this antibiotic in their day-to-day practice.
引言:细菌的多药耐药性(MDR)在全球任何医疗机构都是一个问题。这导致住院时间延长和治疗费用高昂。必须谨慎使用亚胺培南、美罗培南、粘菌素、多粘菌素和替加环素等储备药物。替加环素是治疗新出现的单一或耐多药病原体的主要药物。本研究旨在评估替加环素对MDR分离株的体外敏感性,并比较Kirby–Bauer(KB)圆盘扩散法和Epsilometer(E试验)对各种MDR临床分离株的敏感性。材料和方法:这项前瞻性研究于2019年1月至2020年对临床标本中的MDR分离株进行。采用KB法和E试验法检测分离株对替加环素的抗生素敏感性,以了解替加环肽的最小抑菌浓度(MIC)。统计数据采用百分比法进行分析。结果:在我们的研究中,替加环素对多药耐药菌株显示出更高的体外敏感性。在获得的89个MDR分离株中,38个(42.7)对替加环素敏感,67个(75.3)对E试验敏感。结论:替加环素是一种对抗耐多药生物的储备抗生素,特别适用于治疗革兰氏阳性和革兰氏阴性超级细菌的合并感染。E测试被发现在检测体外活性方面远优于KB方法,该测试的结果将指导临床医生在日常实践中明智地使用这种抗生素。
{"title":"Evaluation of In vitro activity of tigecycline against multidrug-resistant clinical isolates","authors":"Livya Wilson, T. Kuruvilla","doi":"10.4103/ajim.ajim_53_22","DOIUrl":"https://doi.org/10.4103/ajim.ajim_53_22","url":null,"abstract":"Introduction: Multiple drug resistance (MDR) of the bacteria is an issue across any health-care setting worldwide. This leads to prolonged hospital stay and high cost of treatment. One must be cautious to use reserve drugs such as imipenem, meropenem, colistin, polymyxin, and tigecycline. Tigecycline is a mainstay to treat emerging single or MDR pathogens. The study was conducted to assess the in vitro sensitivity of tigecycline to MDR isolates and to compare the sensitivity of Kirby–Bauer (KB) disc-diffusion method with the Epsilometer (E-test) against various MDR clinical isolates. Materials and Methods: This prospective study was done from January 2019 to 2020 on MDR isolates from clinical specimens. The isolates were tested for their antibiotic sensitivity to tigecycline by KB and E-test method to know the minimum inhibitory concentration (MIC) of tigecycline. Statistical data were analyzed by the percentage method. Results: Tigecycline showed a higher in vitro sensitivity against multidrug-resistant isolates in our study. Among the 89 MDR isolates obtained, 38 (42.7) were found to be sensitive to tigecycline by the KB diffusion and 67 (75.3) were sensitive by the E-test method. Conclusions: Tigecycline is a reserve antibiotic against MDR organisms, especially useful to treat coinfections of Gram-positive and Gram-negative superbugs. The E-test was found to be far superior to the KB method to detect in vitro activity and the results of this test will guide the clinician to judiciously use this antibiotic in their day-to-day practice.","PeriodicalId":8012,"journal":{"name":"APIK Journal of Internal Medicine","volume":"11 1","pages":"150 - 153"},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45157382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An introduction to systematic reviews and meta-analyses 系统综述和荟萃分析导论
Pub Date : 2023-07-01 DOI: 10.4103/ajim.ajim_36_23
Shripada C Rao
A high quality systematic review with meta-analysis is considered to provide a high level of evidence in health-care research. It is important to follow rigorous methodology while conducting a systematic review and reporting its findings. To minimize the chances of error and bias, at least two (preferably 3–4) authors should be involved at all stages of the conduct of a systematic review. Registering the protocol on open websites such as PROSPERO is essential to enable transparency and scientific rigor. Important steps are writing the protocol, conducting detailed literature search through multiple databases, identifying studies that meet strict inclusion criteria, abstracting the data, contacting authors to obtain additional information, assessing the risk of bias of included studies, synthesizing evidence qualitatively, conducting meta-analysis using appropriate statistical models, assessing publication bias and heterogeneity, exploring heterogeneity through sensitivity and subgroup analyses, grading the certainty of evidence following the GRADE framework, reporting using the preferred reporting items for systematic reviews and meta-analyses guidelines, describing the limitations and providing implications for clinical practice and future research. Clinicians should evaluate the credibility of systematic reviews prior to applying their results in clinical practice. This article provides a brief introduction to the methodology of systematic reviews and meta-analyses and also provides links to some high-quality free resources for prospective systematic reviewers.
采用荟萃分析的高质量系统综述被认为为医疗保健研究提供了高水平的证据。在进行系统审查和报告调查结果时,必须遵循严格的方法。为了最大限度地减少错误和偏见的机会,系统审查的所有阶段都应至少有两名(最好是3-4名)作者参与。在PROSPERO等开放网站上注册该协议对于实现透明度和科学严谨性至关重要。重要的步骤是编写方案,通过多个数据库进行详细的文献检索,确定符合严格纳入标准的研究,提取数据,联系作者以获得更多信息,评估纳入研究的偏倚风险,定性地综合证据,使用适当的统计模型进行荟萃分析,评估发表偏倚和异质性,通过敏感性和亚组分析探索异质性,根据GRADE框架对证据的确定性进行分级,使用系统综述和荟萃分析指南的首选报告项目进行报告,描述局限性并为临床实践和未来研究提供启示。临床医生在将其结果应用于临床实践之前,应评估系统审查的可信度。本文简要介绍了系统综述和荟萃分析的方法,并为未来的系统综述者提供了一些高质量免费资源的链接。
{"title":"An introduction to systematic reviews and meta-analyses","authors":"Shripada C Rao","doi":"10.4103/ajim.ajim_36_23","DOIUrl":"https://doi.org/10.4103/ajim.ajim_36_23","url":null,"abstract":"A high quality systematic review with meta-analysis is considered to provide a high level of evidence in health-care research. It is important to follow rigorous methodology while conducting a systematic review and reporting its findings. To minimize the chances of error and bias, at least two (preferably 3–4) authors should be involved at all stages of the conduct of a systematic review. Registering the protocol on open websites such as PROSPERO is essential to enable transparency and scientific rigor. Important steps are writing the protocol, conducting detailed literature search through multiple databases, identifying studies that meet strict inclusion criteria, abstracting the data, contacting authors to obtain additional information, assessing the risk of bias of included studies, synthesizing evidence qualitatively, conducting meta-analysis using appropriate statistical models, assessing publication bias and heterogeneity, exploring heterogeneity through sensitivity and subgroup analyses, grading the certainty of evidence following the GRADE framework, reporting using the preferred reporting items for systematic reviews and meta-analyses guidelines, describing the limitations and providing implications for clinical practice and future research. Clinicians should evaluate the credibility of systematic reviews prior to applying their results in clinical practice. This article provides a brief introduction to the methodology of systematic reviews and meta-analyses and also provides links to some high-quality free resources for prospective systematic reviewers.","PeriodicalId":8012,"journal":{"name":"APIK Journal of Internal Medicine","volume":"11 1","pages":"141 - 146"},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45836853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A rare cardiac complication of left-sided tunneled hemodialysis catheter insertion 左侧隧道式血液透析导管置入的罕见心脏并发症
Pub Date : 2023-07-01 DOI: 10.4103/ajim.ajim_79_21
Nishanth Ravindranath, M. Shankar, N. Moorthy, HV Jayanth Kumar
Left atrial perforation during central venous catheter insertion is an extremely rare complication which can have catastrophic outcomes if left unrecognized. We describe a rare case of the left atrial catheter malposition during tunneled hemodialysis catheter insertion from the left internal jugular vein, which was managed successfully by surgical reposition and simultaneously vascular access was secured by salvaging the same catheter in a patient with poor arteriovenous anatomy for surgical arteriovenous fistula.
中心静脉导管插入过程中左心房穿孔是一种极为罕见的并发症,如果不加以识别,可能会导致灾难性后果。我们描述了一例罕见的左心房导管在从左颈内静脉插入隧道式血液透析导管期间错位的病例,该病例通过手术复位成功控制,同时通过抢救动静脉解剖不良的动静脉瘘患者的同一导管来确保血管通路。
{"title":"A rare cardiac complication of left-sided tunneled hemodialysis catheter insertion","authors":"Nishanth Ravindranath, M. Shankar, N. Moorthy, HV Jayanth Kumar","doi":"10.4103/ajim.ajim_79_21","DOIUrl":"https://doi.org/10.4103/ajim.ajim_79_21","url":null,"abstract":"Left atrial perforation during central venous catheter insertion is an extremely rare complication which can have catastrophic outcomes if left unrecognized. We describe a rare case of the left atrial catheter malposition during tunneled hemodialysis catheter insertion from the left internal jugular vein, which was managed successfully by surgical reposition and simultaneously vascular access was secured by salvaging the same catheter in a patient with poor arteriovenous anatomy for surgical arteriovenous fistula.","PeriodicalId":8012,"journal":{"name":"APIK Journal of Internal Medicine","volume":"11 1","pages":"199 - 201"},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46189523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Retraction: A cross-sectional study to evaluate the prevalence and risk factors of gastroesophageal reflux disease among undergraduate medical students of a tertiary care indian setting 撤回:一项横断面研究评估胃食管反流病在印度三级医疗机构的本科医学生中的患病率和危险因素
Pub Date : 2023-07-01 DOI: 10.4103/2666-1802.379798
{"title":"Retraction: A cross-sectional study to evaluate the prevalence and risk factors of gastroesophageal reflux disease among undergraduate medical students of a tertiary care indian setting","authors":"","doi":"10.4103/2666-1802.379798","DOIUrl":"https://doi.org/10.4103/2666-1802.379798","url":null,"abstract":"","PeriodicalId":8012,"journal":{"name":"APIK Journal of Internal Medicine","volume":"11 1","pages":"210 - 210"},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42872513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
APIK Journal of Internal Medicine
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1