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Incidence, mortality, survival, and treatment statistics of cancers in digestive organs—Japanese cancer statistics 2024 消化器官癌症的发病率、死亡率、存活率和治疗统计--2024 年日本癌症统计。
IF 2.9 4区 医学 Q2 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2024-06-17 DOI: 10.1002/ags3.12835
Takahiro Higashi, Yukinori Kurokawa

Access to accurate statistical data is paramount in the pursuit of effective cancer control activities, including research, policy development, and clinical care. This paper presents a comprehensive statistical report on the incidence, mortality, survival, and treatment of major digestive organ cancers, including those of the esophagus, stomach, colon, rectum, liver, extrahepatic biliary tract, and pancreas, in Japan. We compiled data from the National Cancer Center's “Cancer Information Services” and government “e-Stat” websites and offered a succinct overview of basic statistics by using tables and graphical presentations. Our findings underscore the critical role of the National Cancer Registry introduced by the Cancer Registry Act of 2016, which mandates hospitals across Japan to report cancer cases. This system ensures more accurate incidence statistics. Mortality data sourced from the National Vital Statistics System and survival rates derived from hospital-based cancer registries offer insights into the outcomes and efficacy of treatment modalities. These data indicate a downward trend in mortality for stomach and liver cancers and stable or declining rates for other cancers except pancreatic cancer, which has the lowest survival rate. Treatment patterns indicate an increase in endoscopic procedures for esophageal and stomach cancers, with stable treatment approaches for colorectal cancer. This statistical overview aims to improve the understanding and inform research, policy, and clinical decisions in the field of digestive organ cancers.

获取准确的统计数据对于开展有效的癌症控制活动(包括研究、政策制定和临床治疗)至关重要。本文介绍了日本主要消化器官癌症(包括食道癌、胃癌、结肠癌、直肠癌、肝癌、肝外胆道癌和胰腺癌)的发病率、死亡率、存活率和治疗情况的综合统计报告。我们从国立癌症中心的 "癌症信息服务 "和政府的 "e-Stat "网站上收集了数据,并通过表格和图表的形式简明扼要地概述了基本统计数据。我们的研究结果强调了 2016 年《癌症登记法》引入的国家癌症登记系统的关键作用,该系统要求日本全国的医院报告癌症病例。该系统确保了更准确的发病率统计数据。国家生命统计系统提供的死亡率数据和医院癌症登记处提供的存活率有助于了解治疗方法的结果和疗效。这些数据表明,胃癌和肝癌的死亡率呈下降趋势,除存活率最低的胰腺癌外,其他癌症的死亡率稳定或下降。治疗模式表明,食管癌和胃癌的内窥镜手术有所增加,结直肠癌的治疗方法保持稳定。本统计综述旨在加深人们对消化器官癌症的了解,并为研究、政策和临床决策提供参考。
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引用次数: 0
Predictive factors of actual 5-y recurrence-free survival after upfront surgery for resectable pancreatic cancer 可切除胰腺癌前期手术后实际 5 年无复发生存期的预测因素
IF 2.9 4区 医学 Q2 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2024-06-13 DOI: 10.1002/ags3.12834
Masao Uemura, Teiichi Sugiura, Ryo Ashida, Katsuhisa Ohgi, Mihoko Yamada, Shimpei Otsuka, Takeshi Aramaki, Akifumi Notsu, Katsuhiko Uesaka

Aim

The present study investigated the prognostic factors associated with actual 5-y recurrence-free survival (RFS) after upfront surgery for resectable pancreatic cancer (R-PC) in patients who were deemed not to require neoadjuvant treatment.

Methods

Between 2007 and 2016, 316 patients who underwent pancreatectomy for radiologically R-PC were retrospectively reviewed to evaluate the predictors of actual 5-y RFS. Predictors were identified using logistic regression analysis of preoperative evaluable factors. The cutoff values for continuous variables were determined based on a minimum p-value approach (model 1) or the value that maximized the rate of 5-y RFS survivors (model 2).

Results

Fifty-one patients (16.1%) achieved a 5-y RFS. A tumor size ≤23 mm, the absence of serosal invasion on computed tomography (CT), and Neutrophil-to-Lymphocyte Ratio <1.0, were significantly associated with the 5-y RFS in model 1. A Prognostic Nutritional Index ≥58 and the absence of serosal invasion and extrapancreatic nerve plexus invasion on CT were significantly associated with 5-y RFS in model 2. Only six (11.8%, model 1) and four (7.8%, model 2) patients had all three prognostic factors, and their 5-y RFS rates were 83.3% and 100%, respectively.

Conclusions

A modest number of patients who underwent upfront surgery achieved 5-y RFS, but only ~10% of them could be identified preoperatively. Based on these results, almost all R-PC patients are forced to undergo neoadjuvant treatment in daily practice.

本研究调查了被认为不需要新辅助治疗的可切除胰腺癌(R-PC)患者前期手术后实际5年无复发生存期(RFS)的相关预后因素。2007年至2016年期间,对316例因放射学检查为R-PC而接受胰腺切除术的患者进行了回顾性研究,以评估实际5年RFS的预测因素。通过对术前可评估因素进行逻辑回归分析,确定了预测因素。连续变量的临界值根据最小 p 值法(模型 1)或最大化 5 年 RFS 存活率的值(模型 2)确定。在模型1中,肿瘤大小≤23毫米、计算机断层扫描(CT)显示无浆膜侵犯以及中性粒细胞与淋巴细胞比值<1.0与5年RFS显著相关。在模型2中,预后营养指数≥58和CT无浆膜侵犯及胰腺外神经丛侵犯与5年RFS显著相关。只有 6 例(11.8%,模型 1)和 4 例(7.8%,模型 2)患者同时具备这三个预后因素,他们的 5 年 RFS 率分别为 83.3% 和 100% 。基于这些结果,在日常实践中,几乎所有的 R-PC 患者都不得不接受新辅助治疗。
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引用次数: 0
How to measure quality of surgery as a component of multimodality treatment of gastric cancer 如何衡量作为胃癌多模式治疗组成部分的手术质量
IF 2.9 4区 医学 Q2 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2024-06-12 DOI: 10.1002/ags3.12833
Wojciech P. Polkowski, Katarzyna Gęca, Magdalena Skórzewska

Gastric cancer (GC) is one of the most frequent reasons for cancer-related death worldwide. The multimodal therapeutic strategies are now pragmatically tailored to each patient, especially in advanced GC. A radical but safe gastrectomy remains the cornerstone of the GC treatment. Moreover, the quality-of-life (QoL) outcome measures are now routinely utilized in order to select optimal type of gastrectomy, as well as reconstruction method. Postoperative complications are frequent, and effective diagnosis and treatment of complications is crucial to lower the mortality rates. The postoperative complications prolong hospital stay and may result in poor QoL, thus eliminating the completion of perioperative adjuvant therapy. Therefore, avoiding morbidity is not only relevant for the immediate postoperative course, but can also affect long-term oncological outcome. Measuring outcome enables surgeons to: monitor their own results; compare quality of treatment between centres; facilitate improvement both for surgery alone and combined treatment; select optimal procedure for an individual patient. Textbook oncological outcome is a composite quality measure representing the ideal hospitalization for gastrectomy, as well as stage-appropriate (perioperative) adjuvant chemotherapy. Standardized system for recording complications and adherence to multimodality treatment guidelines are crucial for achieving the ultimate goal of surgical quality-improvement that can benefit patients QoL and long-term outcomes after fast and uneventful hospitalization for gastrectomy.

胃癌(GC)是全球最常见的癌症致死原因之一。目前,多模式治疗策略可根据每位患者的实际情况量身定制,尤其是晚期胃癌患者。根治性但安全的胃切除术仍然是胃癌治疗的基石。此外,为了选择最佳的胃切除术类型和重建方法,生活质量(QoL)结果测量已成为常规方法。术后并发症很常见,有效诊断和治疗并发症对降低死亡率至关重要。术后并发症会延长住院时间,并可能导致患者生活质量下降,从而无法完成围手术期辅助治疗。因此,避免发病率不仅关系到术后近期疗程,也会影响长期的肿瘤治疗效果。通过测量疗效,外科医生可以:监测自己的疗效;比较不同中心的治疗质量;促进单独手术和综合治疗的改进;为每位患者选择最佳手术方案。教科书式肿瘤治疗效果是一种综合质量衡量标准,代表了理想的胃切除术住院治疗以及分期(围手术期)辅助化疗。记录并发症的标准化系统和遵守多模式治疗指南对实现提高手术质量的最终目标至关重要,可使患者在快速、顺利住院接受胃切除术后的生活质量和长期预后受益。
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引用次数: 0
Multicenter prospective study on anastomotic leakage after right-sided colon cancer surgery with laparoscopic intracorporeal overlap anastomosis (KYCC 2101) 采用腹腔镜体腔内重叠吻合术(KYCC 2101)进行右侧结肠癌手术后吻合口漏的多中心前瞻性研究
IF 2.9 4区 医学 Q2 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2024-06-05 DOI: 10.1002/ags3.12831
Keisuke Kazama, Masakatsu Numata, Hiroyuki Mushiake, Nobuhiro Sugano, Teni Godai, Akio Higuchi, Tetsushi Ishiguro, Yosuke Atsumi, Satoru Shinoda, Aya Saito

Aim

Intracorporeal anastomosis (IA) is becoming increasingly popular and replacing extracorporeal anastomosis (EA) for reconstruction in laparoscopic and robotic surgery for right-sided colon cancer (LSRCC). Intracorporeal overlap anastomosis (IOA) is the most widely used IA technique. This study aimed to examine the safety of IOA by investigating its short-term results during the implementation phase.

Methods

This multicenter prospective cohort study was conducted by the Kanagawa Yokohama Colorectal Cancer (KYCC) Study Group. Patients with stage 1–3 colon cancer who planned to undergo LSRCC with IOA reconstruction were eligible. The incidence of anastomotic leakage (AL) of Clavien–Dindo (C–D) grade ≥3 was evaluated as the primary endpoint, and other surgical outcomes and postoperative complications of C–D grades ≥2 were the secondary endpoints.

Results

A total of 127 patients were enrolled, of whom 120 were finally analyzed. The incidence of C–D grade ≥2 complications was 8.3%. The incidence of C–D grade ≥3 AL was 0.8%. This trend was lower than that reported in previous randomized controlled trials (RCTs) and acceptable. Additionally, 1.7% of the patients developed abdominal abscesses, and no cases of anastomotic stenosis were observed. The median operative time was 257 min, and the reconstruction procedure required 32 min. Stapler closure of the enterotomy and facility experience of more than 30 cases were associated with a shorter reconstruction time during IOA.

Conclusion

IOA is feasible and can be safely performed during the implementation phase in patients undergoing LSRCC.

在腹腔镜和机器人手术治疗右侧结肠癌(LSRCC)时,体腔内吻合术(IA)正逐渐取代体外吻合术(EA)用于重建手术。体腔内重叠吻合术(IOA)是应用最广泛的IA技术。这项多中心前瞻性队列研究由神奈川横滨大肠癌(KYCC)研究小组进行。这项多中心前瞻性队列研究由神奈川横滨大肠癌研究小组(KYCC Study Group)开展。1-3期大肠癌患者计划接受IOA重建的LSRCC手术。以Clavien-Dindo(C-D)分级≥3级的吻合口漏(AL)发生率为主要终点,以C-D分级≥2级的其他手术结果和术后并发症为次要终点。C-D≥2级并发症的发生率为8.3%。C-D≥3级并发症的发生率为0.8%。这一趋势低于之前的随机对照试验(RCT),可以接受。此外,1.7%的患者出现腹腔脓肿,没有发现吻合口狭窄的病例。手术时间中位数为 257 分钟,重建过程需要 32 分钟。IOA是可行的,并且可以在LSRCC患者的实施阶段安全地进行。
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引用次数: 0
Tailoring rectal cancer surgery: Surgical approaches and anatomical insights during deep pelvic dissection for optimal outcomes in low-lying rectal cancer 定制直肠癌手术:低位直肠癌深盆腔切除术中的手术方法和解剖学见解,以获得最佳疗效
IF 2.9 4区 医学 Q2 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2024-06-04 DOI: 10.1002/ags3.12824
Youn Young Park, Nam Kyu Kim

This review article explores advanced surgical approaches and anatomical insights for tailoring rectal cancer surgery, particularly focusing on low-lying rectal cancer. With the evolution of imaging technologies, precise preoperative planning has become possible, enhancing the visualization of anatomy surrounding the rectum and enabling more accurate assessments of circumferential resection margin (CRM) involvement. The article emphasizes the dynamic nature of rectal cancer treatment, advocating for individualized surgical planning based on comprehensive preoperative imaging and intraoperative assessment. This approach aims to optimize patient care by integrating recent advancements and anatomical insights into clinical practice for the management of low-lying rectal cancer. Particularly, the article discusses the importance of customizing the excision of Denonvilliers' fascia (DVF) based on tumor characteristics for optimal oncologic and functional outcomes, especially for anteriorly located tumors. It highlights the need for precise dissection techniques to ensure a negative CRM while preserving critical anatomical structures. Additionally, the review addresses the surgical management of tumors at the anorectal ring and introduces the Gate Approach for deep anterolateral pelvic dissection. Special attention is given to tumors impacting the membranous and prostate urethra, emphasizing tailored surgical approaches to balance complete tumor resection with the preservation of urogenital functions.

这篇综述文章探讨了定制直肠癌手术的先进手术方法和解剖学见解,尤其侧重于低位直肠癌。随着成像技术的发展,精确的术前规划已成为可能,从而提高了直肠周围解剖结构的可视化程度,并能更准确地评估周缘切除边缘(CRM)受累情况。文章强调了直肠癌治疗的动态性,主张根据全面的术前成像和术中评估制定个体化手术计划。这种方法旨在将最新进展和解剖学见解融入低位直肠癌治疗的临床实践中,从而优化患者护理。文章特别讨论了根据肿瘤特征定制德农维利耶筋膜(DVF)切除术的重要性,以获得最佳的肿瘤学和功能效果,尤其是对于位置靠前的肿瘤。它强调了精确剥离技术的必要性,以确保阴性 CRM,同时保留重要的解剖结构。此外,该综述还讨论了肛门直肠环处肿瘤的手术治疗,并介绍了用于盆腔前外侧深部解剖的 Gate Approach。特别关注影响膜尿道和前列腺尿道的肿瘤,强调量身定制的手术方法,在彻底切除肿瘤和保留泌尿生殖功能之间取得平衡。
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引用次数: 0
Abdominal aortic calcification among gastroenterological and transplant surgery 胃肠外科和移植手术中的腹主动脉钙化
IF 2.9 4区 医学 Q2 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2024-06-04 DOI: 10.1002/ags3.12816
Yuki Imaoka, Masahiro Ohira, Miho Akabane, Kazunari Sasaki, Hideki Ohdan

This review discusses the increasing global trend towards an aging population, which has resulted in a growing number of surgeries being performed on elderly patients, particularly those living with cancer. The focus was on the implications of abdominal aortic calcification (AAC), an indicator of systemic atherosclerosis, in these patients. This comprehensive review provided evidence detailing the complex processes of atherosclerosis and vascular calcification and various approaches to assess this condition. The prevalence of AAC is related to multiple factors, including cardiovascular disease, inflammation, frailty in various types of gastroenterological surgery. Additionally, notable links were found between AAC, postoperative complications, and patient survival following gastroenterological surgery. This study highlights how AAC could negatively impact the health status of elderly patients and undermine treatment efficacy, stressing the need for more research in this domain to improve patient outcomes.

这篇综述讨论了全球人口老龄化趋势日益加剧,导致越来越多的手术在老年患者,尤其是癌症患者身上进行。重点是腹主动脉钙化(AAC)对这些患者的影响,这是全身性动脉粥样硬化的一个指标。这篇综合综述提供的证据详细说明了动脉粥样硬化和血管钙化的复杂过程,以及评估这种情况的各种方法。动脉粥样硬化和血管钙化的发病率与多种因素有关,包括心血管疾病、炎症、各种胃肠外科手术中的虚弱。此外,研究还发现 AAC、术后并发症和胃肠外科手术后患者存活率之间存在显著联系。这项研究强调了AAC如何对老年患者的健康状况产生负面影响并破坏治疗效果,强调了在这一领域开展更多研究以改善患者预后的必要性。
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引用次数: 0
Circ_0084615 promotes epithelial-mesenchymal transition-mediated tumor progression in hepatocellular carcinoma Circ_0084615可促进肝细胞癌中上皮-间质转化介导的肿瘤进展
IF 2.9 4区 医学 Q2 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2024-06-03 DOI: 10.1002/ags3.12828
Yu Wu, Li Peng

Aim

CircRNAs have been identified as crucial regulators in tumorigenesis and progression. This study aimed to explore the biological role and underlying mechanism of circ_0084615 in hepatocellular carcinoma (HCC).

Methods

The expression of RNAs was detected by quantitative reverse transcription-polymerase chain reaction (qRT-PCR). The effects of circ_0084615 silencing on malignant behaviors of HCC cells were assessed by CCK-8, colony formation, wound healing, and Transwell assays in vitro and tumor transplantation experiment in vivo. The expression of proteins was detected by Western blotting. Dual-luciferase reporter assay and RNA-binding protein immunoprecipitation were performed to explore the mechanism of circ_0084615.

Results

A significant upregulation of circ_0084615 was observed in HCC tissues, and positively correlated with the TNM staging. Silencing of circ_0084615 impeded HCC cell viability, colony formation, migration, invasion, epithelial-mesenchymal transition, and xenograft tumor growth. Mechanistically, circ_0084615 could bind to miR-1200 and eliminate its ability to destroy actin-like 6A (ACTL6A) mRNA, thereby increasing ACTL6A expression and facilitating the malignant behaviors of HCC cells.

Conclusions

This study clarified the oncogenic activity and mechanism of circ_0084615, thereby providing potential diagnostic biomarker and therapeutic target for inhibiting HCC progression.

CircRNAs 被认为是肿瘤发生和发展的关键调控因子。本研究旨在探讨 circ_0084615 在肝细胞癌(HCC)中的生物学作用和潜在机制。通过体外 CCK-8、集落形成、伤口愈合和 Transwell 试验以及体内肿瘤移植实验评估了沉默 circ_0084615 对 HCC 细胞恶性行为的影响。蛋白质的表达采用 Western 印迹法检测。在 HCC 组织中观察到 circ_0084615 的显著上调,并与 TNM 分期呈正相关。沉默circ_0084615会阻碍HCC细胞的活力、集落形成、迁移、侵袭、上皮-间质转化以及异种移植肿瘤的生长。从机制上讲,circ_0084615可与miR-1200结合,消除其破坏肌动蛋白样6A(ACTL6A)mRNA的能力,从而增加ACTL6A的表达,促进HCC细胞的恶性行为。这项研究阐明了circ_0084615的致癌活性和机制,从而为抑制HCC进展提供了潜在的诊断生物标志物和治疗靶点。
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引用次数: 0
Identification of lateral pelvic nodes without metastasis in patients with rectal cancer treated with preoperative chemoradiotherapy or chemotherapy based on magnetic resonance imaging 根据磁共振成像确定接受术前化疗或放疗的直肠癌患者盆腔外侧结节无转移情况
IF 2.9 4区 医学 Q2 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2024-06-01 DOI: 10.1002/ags3.12832
Nobuaki Hoshino, Yudai Fukui, Kohei Ueno, Koya Hida, Kazutaka Obama, Kazuhiro Sakamoto, Hirotoshi Kobayashi, Michio Itabashi, Soichiro Ishihara, Kazushige Kawai, Yoichi Ajioka

Background

Intensive localized therapy is promising for the treatment of rectal cancer. In Japan, chemoradiotherapy (CRT) and neoadjuvant chemotherapy (NAC) are used as preoperative treatments for this disease. Magnetic resonance imaging (MRI) is used to diagnose lateral pelvic node (LPN) metastases, but the changes in LPN findings on MRI following preoperative treatment are unclear. Furthermore, there may be patients in whom LPN dissection can be omitted after CRT/NAC.

Methods

Patients who underwent total mesorectal excision with LPN dissection after CRT/NAC at 13 Japanese Society for Cancer of the Colon and Rectum member institutions between 2017 and 2019 were included. Changes in the short diameter of the LPNs after CRT/NAC and the reduction rate were examined.

Results

A total of 101 LPNs were examined in 28 patients who received CRT and 228 in 47 patients who received NAC. Comparison of LPNs before and after CRT/NAC showed that most LPNs shrank after CRT but that the size reduction was variable after NAC. Although some LPNs with a short diameter of <5 mm showed residual metastasis, no metastases were observed in LPNs that were <5 mm in short diameter before and after CRT/NAC and did not shrink after treatment.

Conclusion

Although the short diameter of LPNs was significantly reduced by both CRT and NAC, even LPNs with a short diameter of <5 mm could have residual metastases. However, dissection may be omitted for LPNs <5 mm in short diameter that do not shrink after preoperative CRT or NAC.

强化局部治疗是治疗直肠癌的有效方法。在日本,化放疗(CRT)和新辅助化疗(NAC)被用作该疾病的术前治疗。磁共振成像(MRI)用于诊断侧盆腔结节(LPN)转移,但术前治疗后磁共振成像对 LPN 发现的变化尚不清楚。此外,有些患者在接受 CRT/NAC 治疗后可以省略 LPN 切除术。本文纳入了 2017 年至 2019 年期间在日本结肠直肠癌协会的 13 家会员机构接受全直肠系膜切除术并在 CRT/NAC 治疗后进行 LPN 切除术的患者。共对 28 名接受 CRT 的患者的 101 个 LPN 和 47 名接受 NAC 的患者的 228 个 LPN 进行了检查。对 CRT/NAC 前后的 LPN 进行比较后发现,大多数 LPN 在 CRT 后缩小,但在 NAC 后缩小程度不一。虽然一些短径<5毫米的LPN出现了残余转移,但在CRT/NAC治疗前后短径<5毫米且治疗后未缩小的LPN中未观察到转移。然而,对于术前CRT或NAC治疗后不缩小的短径<5毫米的LPN,可省略剖腹探查。
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引用次数: 0
Impact of perioperative prognostic nutritional index changes on the survival of patients with stage II/III colorectal cancer 围手术期预后营养指数变化对 II/III 期结直肠癌患者生存期的影响。
IF 2.9 4区 医学 Q2 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2024-05-30 DOI: 10.1002/ags3.12826
Kyota Tatsuta, Mayu Sakata, Tadahiro Kojima, Toshiya Akai, Mikihiro Shimizu, Yoshifumi Morita, Hirotoshi Kikuchi, Yoshihiro Hiramatsu, Kiyotaka Kurachi, Hiroya Takeuchi

Aim

To assess the impact of perioperative prognostic nutritional index (PNI) changes on prognosis and recurrence after colorectal cancer surgery.

Methods

A total of 475 patients who underwent curative resection for primary colorectal adenocarcinoma and were diagnosed with pathological stage (pStage) II/III were retrospectively reviewed. The patients were divided into two groups: the high group (preoperative PNI ≤ postoperative PNI, n = 290) and the low group (preoperative PNI > postoperative PNI, n = 185).

Results

The low group exhibited significantly higher recurrence and mortality rates (all p < 0.001). Kaplan–Meier analysis showed worse overall and recurrence-free survival in the low group (all p < 0.001). Perioperative PNI changes predicted prognosis and recurrence independent of preoperative nutritional conditions. Subgroup analyses showed better overall survival and recurrence-free survival in the high group across various parameters, such as patient background, surgical outcomes, adjuvant chemotherapy, and pathological characteristics. Multivariate analysis revealed that the low group based on perioperative PNI changes (hazard ratio [HR]: 5.809, 95% confidence interval [CI]: 3.451–9.779, p < 0.001), pathological T stage (HR: 1.962, 95% CI: 1.184–3.253, p = 0.009), and pathological N stage (HR: 3.434, 95% CI: 1.964–6.004, p < 0.001) were identified as independent predictors of worse overall survival.

Conclusions

Patients with pStage II/III colorectal cancer who demonstrate a lower postoperative PNI levels compared to preoperative had poorer overall survival and recurrence-free survival. Perioperative PNI changes can serve as useful biomarkers for predicting survival and recurrence.

目的:评估围手术期预后营养指数(PNI)变化对结直肠癌手术后预后和复发的影响:方法:回顾性研究了475例接受根治性切除术的原发性结直肠腺癌患者,这些患者被诊断为病理分期(pStage)II/III期。患者被分为两组:高组(术前 PNI ≤ 术后 PNI,n = 290)和低组(术前 PNI > 术后 PNI,n = 185):与术前相比,术后 PNI 水平较低的 p2/III 期结直肠癌患者的总生存率和无复发生存率较低。围手术期 PNI 变化可作为预测生存和复发的有用生物标记物。
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引用次数: 0
Inflammatory Burden Index as a promising new marker for predicting surgical and oncological outcomes in colorectal cancer 将炎症负担指数作为预测结直肠癌手术和肿瘤预后的新标记。
IF 2.9 4区 医学 Q2 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2024-05-28 DOI: 10.1002/ags3.12829
Shinji Yamashita, Yoshinaga Okugawa, Naru Mizuno, Hiroki Imaoka, Tadanobu Shimura, Takahito Kitajima, Mikio Kawamura, Yoshiki Okita, Masaki Ohi, Yuji Toiyama

Aims

The prognosis of colorectal cancer (CRC) has been historically reliant on the Tumor Node Metastasis (TNM) staging system, but there is variability in outcomes among patients at similar stages. Therefore, there is an urgent need for more robust biomarkers. The aim of this study was to assess the clinical feasibility of the recently reported Inflammatory Burden Index (IBI) for predicting short- and long-term outcomes in patients with CRC.

Methods

This was a retrospective observational study of 555 CRC patients undergoing surgery for primary tumor resection. We determined the prognostic value of preoperative IBI for disease-free and overall survival, and its predictive value for perioperative risk of infectious complications, including surgical site infection.

Results

Increased preoperative IBI was significantly associated with advanced disease stage and poor oncological outcome in CRC patients. Higher IBI was independently linked to poorer disease-free and overall survival. Similar outcomes were observed in a subanalysis focused on high-risk stage II and stage III CRC patients. Elevated preoperative IBI was significantly correlated with an increased risk of surgical site infection and other postoperative infectious complications. Propensity score-matching analysis validated the impact of IBI on the prognosis in CRC patients.

Conclusion

We established preoperative IBI as a valuable predictive biomarker for perioperative risks and oncological outcomes in CRC patients. Preoperative IBI is useful for designing effective perioperative management and postoperative oncological follow-up.

目的:结直肠癌(CRC)的预后历来依赖于肿瘤结节转移(TNM)分期系统,但处于类似分期的患者的预后存在差异。因此,迫切需要更可靠的生物标志物。本研究旨在评估最近报道的炎症负担指数(IBI)在预测 CRC 患者短期和长期预后方面的临床可行性:这是一项回顾性观察研究,研究对象是接受原发肿瘤切除手术的 555 例 CRC 患者。我们确定了术前 IBI 对无病生存率和总生存率的预后价值,以及对围手术期感染并发症(包括手术部位感染)风险的预测价值:结果:术前 IBI 增加与 CRC 患者的晚期疾病分期和不良肿瘤预后显著相关。较高的IBI与较差的无病生存率和总生存率有独立联系。在一项针对高危 II 期和 III 期 CRC 患者的子分析中也观察到了类似的结果。术前 IBI 升高与手术部位感染和其他术后感染并发症的风险增加有显著相关性。倾向评分匹配分析验证了IBI对CRC患者预后的影响:我们将术前 IBI 确立为预测 CRC 患者围手术期风险和肿瘤预后的重要生物标记物。术前IBI有助于设计有效的围手术期管理和术后肿瘤学随访。
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引用次数: 0
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Annals of Gastroenterological Surgery
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