首页 > 最新文献

Annals of Gastroenterological Surgery最新文献

英文 中文
Tele-proctoring for minimally invasive surgery across Japan: An initial step toward a new approach to improving the disparity of surgical care and supporting surgical education 日本全国微创手术远程监查:迈向改善外科护理差异和支持外科教育新方法的第一步
IF 2.7 4区 医学 Q1 Medicine Pub Date : 2023-11-21 DOI: 10.1002/ags3.12750
Ichiro Takemasa, Koichi Okuya, Kenji Okita, Emi Akizuki, Masaaki Miyo, Masayuki Ishii, Ryo Miura, Momoko Ichihara, Korai Takahiro, Eiji Oki, Mitsuhisa Takatsuki, Susumu Eguchi, Daisuke Ichikawa, Yuko Kitagawa, Yoshiharu Sakai, Masaki Mori

Aim

The aim of this study was to verify the clinical feasibility of tele-proctoring using our ultra-low latency communication system with shared internet access.

Methods

Connections between two multiple remote locations at various distances were established through the TELEPRO® tele-proctoring system. The server records the latency between the two locations for tele-proctoring using the annotations. Questionnaires were administered to the surgeons, assistants, and medical staff. Respondents rated the quickness and quality of communication in terms of latency and disturbances in the audio, video, and usefulness of the live telestrations with annotation.

Results

Seven hospitals tele-proctored with Sapporo Medical University between January 2021 and September 2022. The median latency of annotation between the two locations ranged from 24.5 to 48.5 ms. No major technological problems occurred, such as streaming interruption, loss of video or audio, poor resolution. The video encoding time was 10 ms, and its decoding time was 0.8 ms. The total latency positively correlated with the distance between two locations (R = 0.55, p < 0.01). The quality of communication regarding latency, disturbance, and surgical education with intraoperative annotative instructions showed similar trends, with perfectly fine being the most common response. No significant differences in surgical quality, educational effect, or social impact were observed between the latency ≥30 and <30 ms groups for whether the size of latency affects surgical education.

Conclusion

The feasibility of the tele-proctoring system is expected to be a sustainable approach to help education for young surgeons and surgical supports in rural areas, thereby reducing disparities in health care.

本研究的目的是验证使用我们的超低延迟通信系统和共享互联网接入进行远程监考的临床可行性。服务器利用注释记录两个远程监考地点之间的延迟。对外科医生、助手和医务人员进行了问卷调查。2021 年 1 月至 2022 年 9 月期间,七家医院与札幌医科大学进行了远程监考。两地之间注释的中位延迟时间为 24.5 至 48.5 毫秒。没有出现流媒体中断、视频或音频丢失、分辨率低等重大技术问题。视频编码时间为 10 毫秒,解码时间为 0.8 毫秒。总延迟时间与两地之间的距离呈正相关(R = 0.55,p < 0.01)。关于延迟、干扰和术中注释说明的手术教育的交流质量显示出相似的趋势,最常见的回答是完全好。就延迟时间的长短是否会影响手术教育而言,延迟时间≥30 毫秒组和<30 毫秒组在手术质量、教育效果或社会影响方面均未发现明显差异。远程监查系统的可行性有望成为帮助农村地区年轻外科医生和手术支持人员接受教育的一种可持续方法,从而缩小医疗保健方面的差距。
{"title":"Tele-proctoring for minimally invasive surgery across Japan: An initial step toward a new approach to improving the disparity of surgical care and supporting surgical education","authors":"Ichiro Takemasa,&nbsp;Koichi Okuya,&nbsp;Kenji Okita,&nbsp;Emi Akizuki,&nbsp;Masaaki Miyo,&nbsp;Masayuki Ishii,&nbsp;Ryo Miura,&nbsp;Momoko Ichihara,&nbsp;Korai Takahiro,&nbsp;Eiji Oki,&nbsp;Mitsuhisa Takatsuki,&nbsp;Susumu Eguchi,&nbsp;Daisuke Ichikawa,&nbsp;Yuko Kitagawa,&nbsp;Yoshiharu Sakai,&nbsp;Masaki Mori","doi":"10.1002/ags3.12750","DOIUrl":"10.1002/ags3.12750","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>The aim of this study was to verify the clinical feasibility of tele-proctoring using our ultra-low latency communication system with shared internet access.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Connections between two multiple remote locations at various distances were established through the TELEPRO® tele-proctoring system. The server records the latency between the two locations for tele-proctoring using the annotations. Questionnaires were administered to the surgeons, assistants, and medical staff. Respondents rated the quickness and quality of communication in terms of latency and disturbances in the audio, video, and usefulness of the live telestrations with annotation.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Seven hospitals tele-proctored with Sapporo Medical University between January 2021 and September 2022. The median latency of annotation between the two locations ranged from 24.5 to 48.5 ms. No major technological problems occurred, such as streaming interruption, loss of video or audio, poor resolution. The video encoding time was 10 ms, and its decoding time was 0.8 ms. The total latency positively correlated with the distance between two locations (<i>R</i> = 0.55, <i>p</i> &lt; 0.01). The quality of communication regarding latency, disturbance, and surgical education with intraoperative annotative instructions showed similar trends, with perfectly fine being the most common response. No significant differences in surgical quality, educational effect, or social impact were observed between the latency ≥30 and &lt;30 ms groups for whether the size of latency affects surgical education.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The feasibility of the tele-proctoring system is expected to be a sustainable approach to help education for young surgeons and surgical supports in rural areas, thereby reducing disparities in health care.</p>\u0000 </section>\u0000 </div>","PeriodicalId":8030,"journal":{"name":"Annals of Gastroenterological Surgery","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2023-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ags3.12750","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139253415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Blood flow ratio in the gastric conduit measured by laser Doppler flowmetry: A predictor of anastomotic leakage after esophagectomy 通过激光多普勒血流测量仪测量胃导管中的血流比率:食管切除术后吻合口漏的预测指标
IF 2.7 4区 医学 Q1 Medicine Pub Date : 2023-11-20 DOI: 10.1002/ags3.12754
Hirotaka Ishida, Toshiaki Fukutomi, Yusuke Taniyama, Chiaki Sato, Hiroshi Okamoto, Yohei Ozawa, Yu Onodera, Ken Koseki, Michiaki Unno, Takashi Kamei

Background

Anastomotic leakage after esophagectomy is a common complication. Laser Doppler flowmetry (LDF) can quantitatively evaluate the blood flow in the gastric conduit.

Methods

A total of 326 patients who underwent thoracoscopic/robot-assisted esophagectomy followed by gastric conduit reconstruction and end-to-side anastomosis were enrolled. We divided the gastric conduit into zones I (dominated by the right gastroepiploic vessels), II (dominated by the left gastroepiploic vessels), and III (perfused with short gastric vessels). Before pulling up the gastric conduit to the neck, LDF values were measured at the pylorus, the border between zones I and II (zone I/II), the border between zones II and III (zone II/III), and the gastric conduit tip (tip). The blood flow ratio was calculated as the LDF value divided by the LDF value at the pylorus.

Results

Anastomotic leakage developed in 32 of 326 patients. Leakage was significantly associated with the blood flow ratio at the tip (p < 0.001), but not at zone I/II, zone II/III, and the anastomotic site. The receiver-operating characteristic curve analysis identified an anastomotic leakage cutoff ratio of 0.41 (at the tip). A multivariate Cox analysis showed that a blood flow ratio <0.41 at the tip was an independent risk factor for anastomotic leakage (p < 0.001).

Conclusion

Anastomotic leakage after esophagectomy was significantly associated with the blood flow ratio at the tip of the gastric conduit. Preservation of the blood supply to the tip via the gastric wall might contribute to a decreased incidence of anastomotic leakage.

食管切除术后吻合口漏是一种常见的并发症。激光多普勒血流测量仪(LDF)可定量评估胃导管内的血流情况。我们共登记了326例接受胸腔镜/机器人辅助食管切除术后进行胃导管重建和端侧吻合术的患者。我们将胃导管分为 I 区(以右胃息肉血管为主)、II 区(以左胃息肉血管为主)和 III 区(以短胃血管灌注)。在将胃导管拉至颈部之前,在幽门、I 区和 II 区交界处(I/II 区)、II 区和 III 区交界处(II/III 区)以及胃导管顶端(顶端)测量 LDF 值。血流比率的计算方法是 LDF 值除以幽门处的 LDF 值。326 例患者中有 32 例出现吻合口渗漏。渗漏与顶端的血流比率有明显关系(p < 0.001),但与 I/II 区、II/III 区和吻合口部位无关。接受者操作特征曲线分析确定吻合口渗漏临界比率为 0.41(顶端)。多变量考克斯分析显示,顶端血流比小于 0.41 是吻合口漏的独立风险因素(p < 0.001)。食管切除术后吻合口漏与胃导管顶端血流比显著相关。食管切除术后吻合口漏与胃导管顶端的血流比率明显相关。通过胃壁保留对顶端的血液供应可能有助于降低吻合口漏的发生率。
{"title":"Blood flow ratio in the gastric conduit measured by laser Doppler flowmetry: A predictor of anastomotic leakage after esophagectomy","authors":"Hirotaka Ishida,&nbsp;Toshiaki Fukutomi,&nbsp;Yusuke Taniyama,&nbsp;Chiaki Sato,&nbsp;Hiroshi Okamoto,&nbsp;Yohei Ozawa,&nbsp;Yu Onodera,&nbsp;Ken Koseki,&nbsp;Michiaki Unno,&nbsp;Takashi Kamei","doi":"10.1002/ags3.12754","DOIUrl":"10.1002/ags3.12754","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Anastomotic leakage after esophagectomy is a common complication. Laser Doppler flowmetry (LDF) can quantitatively evaluate the blood flow in the gastric conduit.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A total of 326 patients who underwent thoracoscopic/robot-assisted esophagectomy followed by gastric conduit reconstruction and end-to-side anastomosis were enrolled. We divided the gastric conduit into zones I (dominated by the right gastroepiploic vessels), II (dominated by the left gastroepiploic vessels), and III (perfused with short gastric vessels). Before pulling up the gastric conduit to the neck, LDF values were measured at the pylorus, the border between zones I and II (zone I/II), the border between zones II and III (zone II/III), and the gastric conduit tip (tip). The blood flow ratio was calculated as the LDF value divided by the LDF value at the pylorus.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Anastomotic leakage developed in 32 of 326 patients. Leakage was significantly associated with the blood flow ratio at the tip (<i>p</i> &lt; 0.001), but not at zone I/II, zone II/III, and the anastomotic site. The receiver-operating characteristic curve analysis identified an anastomotic leakage cutoff ratio of 0.41 (at the tip). A multivariate Cox analysis showed that a blood flow ratio &lt;0.41 at the tip was an independent risk factor for anastomotic leakage (<i>p</i> &lt; 0.001).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Anastomotic leakage after esophagectomy was significantly associated with the blood flow ratio at the tip of the gastric conduit. Preservation of the blood supply to the tip via the gastric wall might contribute to a decreased incidence of anastomotic leakage.</p>\u0000 </section>\u0000 </div>","PeriodicalId":8030,"journal":{"name":"Annals of Gastroenterological Surgery","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2023-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ags3.12754","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139255150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Serum NY-ESO-1 and p53 antibodies as useful tumor markers in gastric cancer 血清 NY-ESO-1 和 p53 抗体是胃癌的有用肿瘤标志物
IF 2.7 4区 医学 Q1 Medicine Pub Date : 2023-11-20 DOI: 10.1002/ags3.12757
Junji Kawada, Takuro Saito, Yukinori Kurokawa, Ryohei Kawabata, Atsushi Takeno, Tomohira Takeoka, Yohei Nose, Hisashi Wada, Hidetoshi Eguchi, Yuichiro Doki, Osaka University Clinical Research Group for Gastroenterological Study

Purpose

The NY-ESO-1 antigen is highly immunogenic and often spontaneously induces an immune response in patients with cancer. We conducted a large-scale multicenter cohort study to investigate the utility of serum NY-ESO-1 and p53 antibodies as predictive markers for the postoperative recurrence of gastric cancer. Here, we examined the usefulness of pre-treatment NY-ESO-1 and p53 antibodies as tumor markers for the diagnosis of gastric cancer in combination with carcinoembryonic antigen (CEA) and carbohydrate antigen 19-9 (CA19-9).

Methods

A total of 1031 patients with cT3-4 gastric cancer were enrolled in the study. NY-ESO-1 and p53 antibodies were assessed prior to treatment. The positivity of NY-ESO-1 and p53 antibodies, CEA, and CA19-9 was evaluated before treatment.

Results

Serum NY-ESO-1 and p53 antibodies were positive in 12.6% and 18.1% of the patients, respectively. Positive NY-ESO-1 antibody response was correlated with male gender, higher cStage, and upper tumor location. However, a positive p53 antibody response was not associated with tumor factors. The combination of NY-ESO-1 or p53 antibody response with CEA and CA19-9, or the 4-factors, was positive in 45.1%, 49.6%, and 53.8% of patients, respectively. Moreover, the 4-factor combination was able to detect >60% of cStage III-IV diseases, which was 14% higher than that with the combination of CEA and CA19-9.

Conclusion

The combination of NY-ESO-1 and p53 antibody responses to CEA and CA19-9 increases the diagnostic accuracy of gastric cancer. Serum NY-ESO-1 and p53 antibodies may be useful tumor markers for gastric cancer.

NY-ESO-1 抗原具有高度免疫原性,通常会自发诱导癌症患者产生免疫反应。我们开展了一项大规模多中心队列研究,以调查血清NY-ESO-1和p53抗体作为胃癌术后复发预测标志物的效用。在此,我们研究了治疗前NY-ESO-1和p53抗体作为肿瘤标志物与癌胚抗原(CEA)和碳水化合物抗原19-9(CA19-9)结合诊断胃癌的实用性。研究共纳入了 1031 名 cT3-4 期胃癌患者,在治疗前评估了 NY-ESO-1 和 p53 抗体。治疗前评估了NY-ESO-1和p53抗体、CEA和CA19-9的阳性率。12.6%和18.1%的患者血清NY-ESO-1和p53抗体呈阳性。NY-ESO-1抗体阳性反应与男性性别、较高的c分期和肿瘤位置偏上有关。然而,p53 抗体阳性反应与肿瘤因素无关。45.1%、49.6% 和 53.8%的患者的 NY-ESO-1 或 p53 抗体反应与 CEA 和 CA19-9 或 4 因子相结合呈阳性。此外,4因子组合能检测出60%以上的cStage III-IV疾病,比CEA和CA19-9组合高出14%。血清NY-ESO-1和p53抗体可能是胃癌的有用肿瘤标志物。
{"title":"Serum NY-ESO-1 and p53 antibodies as useful tumor markers in gastric cancer","authors":"Junji Kawada,&nbsp;Takuro Saito,&nbsp;Yukinori Kurokawa,&nbsp;Ryohei Kawabata,&nbsp;Atsushi Takeno,&nbsp;Tomohira Takeoka,&nbsp;Yohei Nose,&nbsp;Hisashi Wada,&nbsp;Hidetoshi Eguchi,&nbsp;Yuichiro Doki,&nbsp;Osaka University Clinical Research Group for Gastroenterological Study","doi":"10.1002/ags3.12757","DOIUrl":"10.1002/ags3.12757","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Purpose</h3>\u0000 \u0000 <p>The NY-ESO-1 antigen is highly immunogenic and often spontaneously induces an immune response in patients with cancer. We conducted a large-scale multicenter cohort study to investigate the utility of serum NY-ESO-1 and p53 antibodies as predictive markers for the postoperative recurrence of gastric cancer. Here, we examined the usefulness of pre-treatment NY-ESO-1 and p53 antibodies as tumor markers for the diagnosis of gastric cancer in combination with carcinoembryonic antigen (CEA) and carbohydrate antigen 19-9 (CA19-9).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A total of 1031 patients with cT3-4 gastric cancer were enrolled in the study. NY-ESO-1 and p53 antibodies were assessed prior to treatment. The positivity of NY-ESO-1 and p53 antibodies, CEA, and CA19-9 was evaluated before treatment.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Serum NY-ESO-1 and p53 antibodies were positive in 12.6% and 18.1% of the patients, respectively. Positive NY-ESO-1 antibody response was correlated with male gender, higher cStage, and upper tumor location. However, a positive p53 antibody response was not associated with tumor factors. The combination of NY-ESO-1 or p53 antibody response with CEA and CA19-9, or the 4-factors, was positive in 45.1%, 49.6%, and 53.8% of patients, respectively. Moreover, the 4-factor combination was able to detect &gt;60% of cStage III-IV diseases, which was 14% higher than that with the combination of CEA and CA19-9.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The combination of NY-ESO-1 and p53 antibody responses to CEA and CA19-9 increases the diagnostic accuracy of gastric cancer. Serum NY-ESO-1 and p53 antibodies may be useful tumor markers for gastric cancer.</p>\u0000 </section>\u0000 </div>","PeriodicalId":8030,"journal":{"name":"Annals of Gastroenterological Surgery","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2023-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ags3.12757","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139257967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of thoracic shape on the surgical outcomes of laparoscopic-assisted living donor hepatectomy 胸廓形状对腹腔镜辅助活体肝切除术手术效果的影响
IF 2.7 4区 医学 Q1 Medicine Pub Date : 2023-11-17 DOI: 10.1002/ags3.12755
Kosuke Tanaka, Satoshi Ogiso, Tomoaki Yoh, Ahmed Hussein Abdelhafez, Yuki Masano, Shinya Okumura, Shoichi Kageyama, Takashi Ito, Koichiro Hata, Etsuro Hatano

Background

Although laparoscopic-assisted donor hepatectomy (LADH) has become the definitive procedure for harvesting living donor livers, its surgical outcomes in association with donor body shape have not been elucidated.

Methods

The impact of donor factors, including thoracic shape, on LADH outcomes was retrospectively investigated. Thoracic anthropometric data were examined in all LADHs with a left/right graft between 2013 and 2022.

Results

The study included 210 LADHs, consisting of 106 left- and 104 right-lobe donors with similar blood loss and similar operation time. Males have greater thoracic depth and greater thoracic width compared with females, respectively. Thoracic depth was associated with graft weight (p < 0.001), blood loss (p < 0.001), and operation time (p < 0.001). On multivariate analyses, blood loss >500 mL and operation time >8 h were associated with graft weight in the left-lobe donors, and blood loss >500 mL was associated with thoracic depth in the right-lobe donors.

Conclusion

The greater thoracic depth is associated with massive blood loss in right-lobe donors. Anthropometric parameters might be helpful for estimating LADH outcomes.

虽然腹腔镜辅助供体肝切除术(LADH)已成为获取活体供体肝脏的权威手术,但其手术效果与供体体形的关系尚未阐明。研究人员回顾性地调查了供体因素(包括胸廓形状)对LADH手术效果的影响。研究纳入了210例LADH,包括106例左叶和104例右叶供体,失血量和手术时间相似。与女性相比,男性的胸廓深度更大,胸廓宽度更大。左叶供体的胸廓深度与移植物重量(p 500 mL)相关,手术时间大于 8 小时与移植物重量相关,右叶供体的失血量大于 500 mL 与胸廓深度相关。人体测量参数可能有助于估计 LADH 的结果。
{"title":"Impact of thoracic shape on the surgical outcomes of laparoscopic-assisted living donor hepatectomy","authors":"Kosuke Tanaka,&nbsp;Satoshi Ogiso,&nbsp;Tomoaki Yoh,&nbsp;Ahmed Hussein Abdelhafez,&nbsp;Yuki Masano,&nbsp;Shinya Okumura,&nbsp;Shoichi Kageyama,&nbsp;Takashi Ito,&nbsp;Koichiro Hata,&nbsp;Etsuro Hatano","doi":"10.1002/ags3.12755","DOIUrl":"10.1002/ags3.12755","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Although laparoscopic-assisted donor hepatectomy (LADH) has become the definitive procedure for harvesting living donor livers, its surgical outcomes in association with donor body shape have not been elucidated.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>The impact of donor factors, including thoracic shape, on LADH outcomes was retrospectively investigated. Thoracic anthropometric data were examined in all LADHs with a left/right graft between 2013 and 2022.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The study included 210 LADHs, consisting of 106 left- and 104 right-lobe donors with similar blood loss and similar operation time. Males have greater thoracic depth and greater thoracic width compared with females, respectively. Thoracic depth was associated with graft weight (<i>p</i> &lt; 0.001), blood loss (<i>p</i> &lt; 0.001), and operation time (<i>p</i> &lt; 0.001). On multivariate analyses, blood loss &gt;500 mL and operation time &gt;8 h were associated with graft weight in the left-lobe donors, and blood loss &gt;500 mL was associated with thoracic depth in the right-lobe donors.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The greater thoracic depth is associated with massive blood loss in right-lobe donors. Anthropometric parameters might be helpful for estimating LADH outcomes.</p>\u0000 </section>\u0000 </div>","PeriodicalId":8030,"journal":{"name":"Annals of Gastroenterological Surgery","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2023-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ags3.12755","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139262467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical characteristics and management of primary retroperitoneal sarcoma: A literature review 原发性腹膜后肉瘤的临床特征和治疗:文献综述
IF 2.7 4区 医学 Q1 Medicine Pub Date : 2023-11-16 DOI: 10.1002/ags3.12756
Yukinori Yamagata, Motokiyo Komiyama, Shintaro Iwata

Retroperitoneal sarcoma (RPS) is a rare tumor classified into many histological types. It is also often detected only after it has grown to a considerable size and requires extensive resection of the surrounding organs, making it difficult to offer optimal patient-tailored management. Evidence supporting specific treatment modalities for RPS is insufficient, owing to its rarity. The Japanese clinical practice guidelines for RPS were published in December 2021, with the aim of accumulating existing evidence and indicating the optimal practice for RPS. These guidelines provide important clinical questions (CQs) concerning the diagnosis and treatment of RPS. This review, with a particular focus on primary RPS, attempts to introduce clinical problems in the diagnosis and treatment of RPS and to assess those problems along with the CQs in the guidelines. According to these guidelines, although chemotherapy and radiotherapy are expected to have therapeutic effects, the level of evidence to support these treatments is not very high at present. Accordingly, complete resection of the tumor is the first and only option for managing primary RPS. However, as with other tumors, the demand for multidisciplinary treatment for RPS is increasing. These guidelines will undoubtedly represent a milestone in clinical practice in relation to RPS in the future, and further evidence is expected to be accumulated based on the CQs that have been proposed.

腹膜后肉瘤(RPS)是一种罕见肿瘤,可分为多种组织学类型。它通常在肿瘤长到相当大时才被发现,需要对周围器官进行大面积切除,因此很难为患者提供最佳的治疗方案。由于其罕见性,支持 RPS 特定治疗方式的证据不足。日本于 2021 年 12 月发布了 RPS 临床实践指南,旨在积累现有证据并指出 RPS 的最佳治疗方法。这些指南提供了有关 RPS 诊断和治疗的重要临床问题(CQs)。本综述特别关注原发性 RPS,试图介绍 RPS 诊断和治疗中的临床问题,并结合指南中的 CQs 对这些问题进行评估。根据这些指南,虽然化疗和放疗有望产生治疗效果,但目前支持这些治疗的证据水平并不高。因此,完全切除肿瘤是治疗原发性 RPS 的首要和唯一选择。然而,与其他肿瘤一样,RPS 的多学科治疗需求也在不断增加。这些指南无疑将成为未来 RPS 临床实践的一个里程碑,并有望在已提出的 CQs 基础上积累更多证据。
{"title":"Clinical characteristics and management of primary retroperitoneal sarcoma: A literature review","authors":"Yukinori Yamagata,&nbsp;Motokiyo Komiyama,&nbsp;Shintaro Iwata","doi":"10.1002/ags3.12756","DOIUrl":"10.1002/ags3.12756","url":null,"abstract":"<p>Retroperitoneal sarcoma (RPS) is a rare tumor classified into many histological types. It is also often detected only after it has grown to a considerable size and requires extensive resection of the surrounding organs, making it difficult to offer optimal patient-tailored management. Evidence supporting specific treatment modalities for RPS is insufficient, owing to its rarity. The Japanese clinical practice guidelines for RPS were published in December 2021, with the aim of accumulating existing evidence and indicating the optimal practice for RPS. These guidelines provide important clinical questions (CQs) concerning the diagnosis and treatment of RPS. This review, with a particular focus on primary RPS, attempts to introduce clinical problems in the diagnosis and treatment of RPS and to assess those problems along with the CQs in the guidelines. According to these guidelines, although chemotherapy and radiotherapy are expected to have therapeutic effects, the level of evidence to support these treatments is not very high at present. Accordingly, complete resection of the tumor is the first and only option for managing primary RPS. However, as with other tumors, the demand for multidisciplinary treatment for RPS is increasing. These guidelines will undoubtedly represent a milestone in clinical practice in relation to RPS in the future, and further evidence is expected to be accumulated based on the CQs that have been proposed.</p>","PeriodicalId":8030,"journal":{"name":"Annals of Gastroenterological Surgery","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2023-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ags3.12756","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139267681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Oligo-like liver metastasis: A novel prognostic indicator to improve survival in pancreatic cancer 寡核苷酸样肝转移:提高胰腺癌患者生存率的新预后指标
IF 2.7 4区 医学 Q1 Medicine Pub Date : 2023-11-13 DOI: 10.1002/ags3.12753
Ryo Saito, Daisuke Ban, Takahiro Mizui, Takeshi Takamoto, Satoshi Nara, Minoru Esaki, Kazuaki Shimada

Purpose

Whether surgical intervention for patients with oligometastatic recurrence can improve their post-recurrent prognosis is unclear. In this study, we introduce a novel concept of oligometastasis in post-surgical pancreatic ductal adenocarcinoma (PDAC) patients with hepatic recurrence, which we call “oligo-like liver metastasis (OLLM).” Patients with OLLM have better post-recurrence prognosis and could therefore be eligible for surgical intervention.

Methods

A total of 121 PDAC patients who underwent radical resection, and who had an initial and single-organ metastasis to the liver, were analyzed. Independent prognostic factors for overall survival after recurrence (OSAR) were examined, and patients with all of these factors were defined as OLLM. The clinicopathological features and post-recurrent prognosis of OLLM patients were evaluated. In addition, a detailed analysis using the oligo-score, which was based on the prognostic factors, was performed.

Results

The prognostic analysis revealed that short recurrence-free interval (RFI) (<6 months), short stable disease interval (SDI) (≤3 months), and four or more recurrent tumors were independent poor prognostic factors. OLLM patients were defined as those with all three conditions: long RFI (≥6 months), long SDI (>3 months), and three or less recurrent tumors. OLLM patients had a significantly better prognosis for OSAR than non-OLLM patients (HR = 0.272, p < 0.001). Further analysis demonstrated that the OSAR of patients could be stratified using the oligo-score, which was calculated based on the prognostic factors.

Conclusion

We recommend that OLLM should be used to predict which patients are most likely to experience better post-recurrent prognosis after surgery with curative intent.

目的 对少转移复发患者进行手术干预能否改善其复发后的预后尚不清楚。在本研究中,我们提出了一个新的概念,即胰腺导管腺癌(PDAC)术后肝复发患者的寡转移,我们称之为 "寡样肝转移(OLLM)"。OLLM患者复发后的预后较好,因此符合手术治疗的条件。 方法 对121例接受根治性切除术的PDAC患者进行了分析,这些患者最初都有单器官肝转移。研究了复发后总生存期(OSAR)的独立预后因素,并将具备所有这些因素的患者定义为 OLLM。评估了 OLLM 患者的临床病理特征和复发后的预后。此外,还使用基于预后因素的寡核苷酸评分进行了详细分析。 结果 预后分析表明,无复发间期(RFI)短(6 个月)、疾病稳定间期(SDI)短(≤3 个月)和四个或四个以上复发肿瘤是独立的不良预后因素。OLLM患者被定义为同时具备长RFI(≥6个月)、长SDI(3个月)和3个或3个以下复发肿瘤这三个条件的患者。OLLM患者的OSAR预后明显优于非OLLM患者(HR = 0.272,p <0.001)。进一步分析表明,根据预后因素计算出的寡核苷酸评分可对患者的 OSAR 进行分层。 结论 我们建议使用 OLLM 来预测哪些患者在治愈性手术后最有可能获得更好的复发后预后。
{"title":"Oligo-like liver metastasis: A novel prognostic indicator to improve survival in pancreatic cancer","authors":"Ryo Saito,&nbsp;Daisuke Ban,&nbsp;Takahiro Mizui,&nbsp;Takeshi Takamoto,&nbsp;Satoshi Nara,&nbsp;Minoru Esaki,&nbsp;Kazuaki Shimada","doi":"10.1002/ags3.12753","DOIUrl":"10.1002/ags3.12753","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Purpose</h3>\u0000 \u0000 <p>Whether surgical intervention for patients with oligometastatic recurrence can improve their post-recurrent prognosis is unclear. In this study, we introduce a novel concept of oligometastasis in post-surgical pancreatic ductal adenocarcinoma (PDAC) patients with hepatic recurrence, which we call “oligo-like liver metastasis (OLLM).” Patients with OLLM have better post-recurrence prognosis and could therefore be eligible for surgical intervention.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A total of 121 PDAC patients who underwent radical resection, and who had an initial and single-organ metastasis to the liver, were analyzed. Independent prognostic factors for overall survival after recurrence (OSAR) were examined, and patients with all of these factors were defined as OLLM. The clinicopathological features and post-recurrent prognosis of OLLM patients were evaluated. In addition, a detailed analysis using the oligo-score, which was based on the prognostic factors, was performed.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The prognostic analysis revealed that short recurrence-free interval (RFI) (&lt;6 months), short stable disease interval (SDI) (≤3 months), and four or more recurrent tumors were independent poor prognostic factors. OLLM patients were defined as those with all three conditions: long RFI (≥6 months), long SDI (&gt;3 months), and three or less recurrent tumors. OLLM patients had a significantly better prognosis for OSAR than non-OLLM patients (HR = 0.272, <i>p</i> &lt; 0.001). Further analysis demonstrated that the OSAR of patients could be stratified using the oligo-score, which was calculated based on the prognostic factors.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>We recommend that OLLM should be used to predict which patients are most likely to experience better post-recurrent prognosis after surgery with curative intent.</p>\u0000 </section>\u0000 </div>","PeriodicalId":8030,"journal":{"name":"Annals of Gastroenterological Surgery","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2023-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ags3.12753","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136352097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Surgical education through integration of robotic telesurgical technology and AI 通过整合机器人远程手术技术和人工智能进行外科教育。
IF 2.7 4区 医学 Q1 Medicine Pub Date : 2023-10-31 DOI: 10.1002/ags3.12751
Kenichi Hakamada

Robotic surgery technology is now fusing with ICT (information and communications technology) and AI (artificial intelligence) to bring about new changes in surgical education.

In robotic surgery, images of the surgical field are converted into digital signals by a 3D high-definition camera and transmitted to the surgeon's viewer, and surgical operations are digitally converted into 3D coordinate axis information and acceleration information, which are transmitted to the robotic arm and accurately reproduced as forceps manipulations. Therefore, robotic surgery can be described as a digitization technology for surgery.

Robotic surgery enables surgery without motion restrictions under detailed images deep inside the body, and the number of surgeries, especially in the field of gastrointestinal surgery, is increasing due to expectations for precision. In this volume, McCarron et al. report that they started a robotic HPB program in 2008, performed 100% of Whipple procedures by 2020, and over 1600 complex hepatobiliary surgeries by robotic surgery to date. Unfortunately, at this time, there is still little evidence of a clinical long-term outcome advantage of robotic surgery over laparoscopic surgery, but the digitization technology of surgery offers two major enhancements besides precision.

The first is telesurgery integrated with ICT. Robotic surgery began to be developed in the 1970s for use in outer space and on the battlefield. Later, as military technology was converted to civilian use, development progressed as surgical robots for general medical use. In 2001, the world's first cholecystectomy was performed by connecting New York and Strasbourg, France via a dedicated line, followed by 22 cases of abdominal surgery in Canada. All these early attempts were reportedly successful, but unacceptably long transmission delay times, high communication costs, inadequate communication security, and even the discontinuation of surgical robotics led to a setback in the development of telesurgery technology. However, recent advances in ICT, the development of high-speed communication networks, and the development of new telesurgery-compatible robots have led to a re-evaluation of telerobotic surgery.

In Japan, following the legal establishment of telesurgery in 2019, the Japan Surgical Society has established a project team to conduct research on the social implementation of telesurgery. It was found that the transmission delay, which is the biggest barrier in implementing telesurgery, does not affect surgical operations as long as it is less than 100 ms.1 In 15 telesurgery experiments conducted using commercial lines by September 2023, the communication delay between two sites 100–700 km apart was 4–25 ms round-trip, and the total delay time, including the video information processing time, was about 50 ms.2-4 In these remote surgical environments, we have performed several porcine

机器人手术技术正在与ICT(信息通信技术)和AI(人工智能)融合,给外科教育带来新的变化。在机器人手术中,手术场的图像通过3D高清摄像机转换为数字信号传输给外科医生的观察者,手术操作被数字化转换为3D坐标轴信息和加速度信息,传输给机械臂,并精确地再现为钳子操作。因此,机器人手术可以说是一种手术的数字化技术。机器人手术可以在身体深处的详细图像下进行不受运动限制的手术,而且由于对精度的期望,特别是在胃肠手术领域的手术数量正在增加。在本卷中,McCarron等人报告说,他们在2008年启动了机器人HPB项目,到2020年完成了100%的惠普尔手术,迄今为止完成了1600多例复杂的肝胆手术。不幸的是,目前仍然很少有证据表明机器人手术比腹腔镜手术具有临床长期疗效优势,但手术的数字化技术除了精度之外还提供了两个主要的增强。第一个是与信息通信技术相结合的远程手术。机器人手术在20世纪70年代开始发展,用于外太空和战场。后来,随着军事技术转为民用,发展成为一般医疗用途的手术机器人。2001年,世界首例胆囊切除手术通过专线连接纽约和法国斯特拉斯堡,随后在加拿大进行了22例腹部手术。据报道,所有这些早期的尝试都取得了成功,但传输延迟时间长,通信成本高,通信安全性不足,甚至手术机器人的停止都导致了远程外科技术发展的挫折。然而,信息通信技术的最新进展、高速通信网络的发展以及新型远程手术兼容机器人的发展导致了对远程机器人手术的重新评估。在日本,继2019年远程外科合法成立之后,日本外科学会成立了一个项目组,对远程外科的社会实施进行研究。研究发现,传输延迟是实施远程外科手术的最大障碍,但只要传输延迟小于100毫秒,就不会影响外科手术截至2023年9月,利用商业线路进行的15次远程外科实验中,相距100-700 km的两个站点之间的通信延迟往返为4-25 ms,包括视频信息处理时间在内的总延迟时间约为50 ms。2-4在这些远程手术环境中,我们使用两台手术机器人(Medicaroid的hinotori和Riverfield的Saroa)进行了几例猪胃切除术、直肠切除术、胆囊切除术和肾切除术,并确认它们可以安全进行。我们还证实,对大型船舶损伤进行紧急修复是可能的此外,尸体式幽门胃切除术和全胃切除术已被证实与临床手术一样准确此外,机器人公司还开发了用于远程手术指导的双座舱和用于远程绘制外科手术视频的注释设备,为使用远程外科技术的外科教育创造了新的环境。手术数字化的第二个延伸是它与人工智能的整合。尽管目前许多外科医生对手术自动化持怀疑态度,但利用外科医生从优秀的数字化手术视频中标记的数据进行机器学习的系统,可以分割手术场景,并识别手术视频中的胆囊和血管等结构,这些系统已经在商业基础上用于外科教育。此外,人们对通过积累和机器学习优秀的外科手术,将该系统用作外科导航系统抱有很高的期望。外科数字化有望提高外科教育过程的效率。另一方面,以机器人手术为中心的外科教育也有其局限性。除了少数机器人之外,许多机器人仍然没有触觉。人的手的触觉包括多种功能,既有浅表(触觉、疼痛、温度)感,也有深层(压力、位置、振动等)感,也有皮质感(两点辨别、三维辨别能力等)。此外,人手拥有的传感器数量远远超过机器人。可以说,人类仍然是更好的机器人。 然而,生成式人工智能的出现将加速科学技术的发展,并可能轻松解决这些问题。这样一来,机器人手术的安全性就会提高,利用远端外科技术进行外科教育的有效性也会进一步提高。数字化外科将极大地改变外科教育的方法和质量,使外科教育超越空间和距离的限制。作者声明本文无利益冲突。
{"title":"Surgical education through integration of robotic telesurgical technology and AI","authors":"Kenichi Hakamada","doi":"10.1002/ags3.12751","DOIUrl":"10.1002/ags3.12751","url":null,"abstract":"<p>Robotic surgery technology is now fusing with ICT (information and communications technology) and AI (artificial intelligence) to bring about new changes in surgical education.</p><p>In robotic surgery, images of the surgical field are converted into digital signals by a 3D high-definition camera and transmitted to the surgeon's viewer, and surgical operations are digitally converted into 3D coordinate axis information and acceleration information, which are transmitted to the robotic arm and accurately reproduced as forceps manipulations. Therefore, robotic surgery can be described as a digitization technology for surgery.</p><p>Robotic surgery enables surgery without motion restrictions under detailed images deep inside the body, and the number of surgeries, especially in the field of gastrointestinal surgery, is increasing due to expectations for precision. In this volume, McCarron et al. report that they started a robotic HPB program in 2008, performed 100% of Whipple procedures by 2020, and over 1600 complex hepatobiliary surgeries by robotic surgery to date. Unfortunately, at this time, there is still little evidence of a clinical long-term outcome advantage of robotic surgery over laparoscopic surgery, but the digitization technology of surgery offers two major enhancements besides precision.</p><p>The first is telesurgery integrated with ICT. Robotic surgery began to be developed in the 1970s for use in outer space and on the battlefield. Later, as military technology was converted to civilian use, development progressed as surgical robots for general medical use. In 2001, the world's first cholecystectomy was performed by connecting New York and Strasbourg, France via a dedicated line, followed by 22 cases of abdominal surgery in Canada. All these early attempts were reportedly successful, but unacceptably long transmission delay times, high communication costs, inadequate communication security, and even the discontinuation of surgical robotics led to a setback in the development of telesurgery technology. However, recent advances in ICT, the development of high-speed communication networks, and the development of new telesurgery-compatible robots have led to a re-evaluation of telerobotic surgery.</p><p>In Japan, following the legal establishment of telesurgery in 2019, the Japan Surgical Society has established a project team to conduct research on the social implementation of telesurgery. It was found that the transmission delay, which is the biggest barrier in implementing telesurgery, does not affect surgical operations as long as it is less than 100 ms.<span><sup>1</sup></span> In 15 telesurgery experiments conducted using commercial lines by September 2023, the communication delay between two sites 100–700 km apart was 4–25 ms round-trip, and the total delay time, including the video information processing time, was about 50 ms.<span><sup>2-4</sup></span> In these remote surgical environments, we have performed several porcine","PeriodicalId":8030,"journal":{"name":"Annals of Gastroenterological Surgery","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2023-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71477272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Using extracorporeal membrane oxygenation in donations after cardiac death or brain death: A single-center experience and long-term outcome 在心脏死亡或脑死亡后的捐赠中使用体外膜氧合:单个中心的经验和长期结果
IF 2.7 4区 医学 Q1 Medicine Pub Date : 2023-10-22 DOI: 10.1002/ags3.12749
Chia-En Hsieh, Ya-Lan Hsu, Yao-Li Chen, Hsin-Rou Liang, Kuo-Hua Lin, Wen-Yuan Chen, Hsiu-Man Wu, Sin-Bao Hunang, Yu-Ju Hung

Aims

The use of extended criteria donors is a routine practice that sometimes involves extracorporeal membrane oxygenation (ECMO) in donations after cardiac death or brain death.

Methods

We performed a retrospective study in a single center from January 2006 to December 2019. The study included 90 deceased donor liver transplants. The patients were divided into three groups: the donation after brain death (DBD) group (n = 58, 64.4%), the DBD with ECMO group (n = 11, 12.2%) and the donation after cardiac death (DCD) with ECMO group (n = 21, 23.3%).

Results

There were no significant differences between the DBD with ECMO group and the DBD group. When comparing the DCD with ECMO group and the DBD group, there were statistically significant differences for total warm ischemia time (p < 0.001), total cold ischemia time (p = 0.023), and split liver transplantation (p < 0.001), and there was significantly poor recovery in regard to total bilirubin level (p = 0.027) for the DCD with ECMO group by repeated measures ANOVA. The 5-year survival rates of the DBD, DBD with ECMO, and DCD with ECMO groups were 78.1%, 90.9%, and 75.6%, respectively. The survival rate was not significantly different when comparing the DBD group to either the DBD with ECMO group (p = 0.435) or the DCD with ECMO group (p = 0.310).

Conclusions

Using ECMO in donations after cardiac death or brain death is a good technology, and it contributed to 35.6% of the liver graft pool.

目的 在心脏死亡或脑死亡后的捐献中,使用扩展标准捐献者是一种常规做法,有时涉及体外膜氧合(ECMO)。 方法 我们在一个中心进行了一项回顾性研究,研究时间为 2006 年 1 月至 2019 年 12 月。研究包括 90 例死亡供体肝移植。患者分为三组:脑死亡后捐献(DBD)组(n = 58,64.4%)、DBD 合并 ECMO 组(n = 11,12.2%)和心脏死亡后捐献(DCD)合并 ECMO 组(n = 21,23.3%)。 结果 有 ECMO 的 DBD 组与 DBD 组之间无明显差异。经重复测量方差分析,DCD伴ECMO组与DBD组在总温热缺血时间(p <0.001)、总冷缺血时间(p = 0.023)和分肝移植(p <0.001)方面差异有统计学意义,而DCD伴ECMO组在总胆红素水平(p = 0.027)方面恢复明显较差。DBD组、DBD伴ECMO组和DCD伴ECMO组的5年存活率分别为78.1%、90.9%和75.6%。DBD 组与 DBD 伴 ECMO 组(P = 0.435)或 DCD 伴 ECMO 组(P = 0.310)相比,存活率无明显差异。 结论 在心脏死亡或脑死亡后的捐献中使用 ECMO 是一项很好的技术,它占肝脏移植库的 35.6%。
{"title":"Using extracorporeal membrane oxygenation in donations after cardiac death or brain death: A single-center experience and long-term outcome","authors":"Chia-En Hsieh,&nbsp;Ya-Lan Hsu,&nbsp;Yao-Li Chen,&nbsp;Hsin-Rou Liang,&nbsp;Kuo-Hua Lin,&nbsp;Wen-Yuan Chen,&nbsp;Hsiu-Man Wu,&nbsp;Sin-Bao Hunang,&nbsp;Yu-Ju Hung","doi":"10.1002/ags3.12749","DOIUrl":"10.1002/ags3.12749","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aims</h3>\u0000 \u0000 <p>The use of extended criteria donors is a routine practice that sometimes involves extracorporeal membrane oxygenation (ECMO) in donations after cardiac death or brain death.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We performed a retrospective study in a single center from January 2006 to December 2019. The study included 90 deceased donor liver transplants. The patients were divided into three groups: the donation after brain death (DBD) group (<i>n</i> = 58, 64.4%), the DBD with ECMO group (<i>n</i> = 11, 12.2%) and the donation after cardiac death (DCD) with ECMO group (<i>n</i> = 21, 23.3%).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>There were no significant differences between the DBD with ECMO group and the DBD group. When comparing the DCD with ECMO group and the DBD group, there were statistically significant differences for total warm ischemia time (<i>p</i> &lt; 0.001), total cold ischemia time (<i>p</i> = 0.023), and split liver transplantation (<i>p</i> &lt; 0.001), and there was significantly poor recovery in regard to total bilirubin level (<i>p</i> = 0.027) for the DCD with ECMO group by repeated measures ANOVA. The 5-year survival rates of the DBD, DBD with ECMO, and DCD with ECMO groups were 78.1%, 90.9%, and 75.6%, respectively. The survival rate was not significantly different when comparing the DBD group to either the DBD with ECMO group (<i>p</i> = 0.435) or the DCD with ECMO group (<i>p</i> = 0.310).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Using ECMO in donations after cardiac death or brain death is a good technology, and it contributed to 35.6% of the liver graft pool.</p>\u0000 </section>\u0000 </div>","PeriodicalId":8030,"journal":{"name":"Annals of Gastroenterological Surgery","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2023-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ags3.12749","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135462783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Requirements for hospitals in Japan to have low operative mortality and failure-to-rescue rates 日本医院手术死亡率和抢救失败率低的要求
IF 2.7 4区 医学 Q1 Medicine Pub Date : 2023-10-16 DOI: 10.1002/ags3.12745
Itaru Endo, Arata Takahashi, Hisateru Tachimori, Hiroaki Miyata, Yuki Homma, Takafumi Kumamoto, Ryusei Matsuyama, Yoshihiro Kakeji, Yuko Kitagawa, Yasuyuki Seto

Aim

We explored institutional factors in Japan associated with lower operative mortality and failure-to-rescue (FTR) rates for eight major gastrointestinal procedures.

Methods

A 22-item online questionnaire was sent to 2119 institutional departments (IDs) to examine the association between institutional factors and operative mortality and FTR rates. IDs were classified according to the number of annual surgeries, board certification status, and locality. In addition, the top 20% and bottom 20% of IDs were identified based on FTR rates and matched with the results of the questionnaire survey. Factors associated with operative mortality were selected by multivariate analysis.

Results

Of the 1083 IDs that responded to the questionnaire, 568 (213 382 patients) were included in the analysis. Operative morbidity, operative mortality, and FTR rates in the top 20% and bottom 20% of IDs were 13.1% and 8.4% (p < 0.001), 0.52% and 4.3% (p < 0.001), and 4.0% and 51.2% (p < 0.001), respectively. Based on the patients' background characteristics, the top 20% of IDs handled more advanced cases. No significant difference in locality was seen between better or worse hospital FTR rates, but fewer esophagectomies, hepatectomies, and pancreatoduodenectomies were performed in depopulated areas. Six items were found to be associated with operative mortality by multivariate logistic analysis. Only 50 (8.8%) IDs met all five factors related to better FTR rates.

Conclusions

The present findings indicate that several hospital factors surrounding surgical treatment, characterized by abundant human resources, are closely related to better postoperative recovery from severe complications.

目的 我们探讨了日本八种主要胃肠道手术中与较低手术死亡率和抢救失败率(FTR)相关的机构因素。 方法 向 2119 个机构部门(ID)发送了一份包含 22 个项目的在线问卷,以研究机构因素与手术死亡率和抢救失败率之间的关联。根据年度手术数量、委员会认证状况和地区对科室进行了分类。此外,还根据FTR率确定了前20%和后20%的ID,并与问卷调查结果进行了比对。通过多变量分析筛选出与手术死亡率相关的因素。 结果 在回复问卷的 1083 家 ID 中,有 568 家(213 382 名患者)被纳入分析范围。排名前 20% 和后 20% 的 ID 的手术发病率、手术死亡率和 FTR 率分别为 13.1% 和 8.4% (p <0.001)、0.52% 和 4.3% (p <0.001)、4.0% 和 51.2% (p <0.001)。根据患者的背景特征,排名前 20% 的 ID 处理了更多的晚期病例。较好或较差医院的 FTR 率在地区上没有明显差异,但人口稀少地区的食管切除术、肝切除术和胰十二指肠切除术较少。通过多变量逻辑分析发现,有六个项目与手术死亡率有关。只有 50 个(8.8%)ID 符合与更好的 FTR 率相关的所有五个因素。 结论 本研究结果表明,以人力资源丰富为特点的外科治疗周围的几个医院因素与术后严重并发症的恢复密切相关。
{"title":"Requirements for hospitals in Japan to have low operative mortality and failure-to-rescue rates","authors":"Itaru Endo,&nbsp;Arata Takahashi,&nbsp;Hisateru Tachimori,&nbsp;Hiroaki Miyata,&nbsp;Yuki Homma,&nbsp;Takafumi Kumamoto,&nbsp;Ryusei Matsuyama,&nbsp;Yoshihiro Kakeji,&nbsp;Yuko Kitagawa,&nbsp;Yasuyuki Seto","doi":"10.1002/ags3.12745","DOIUrl":"10.1002/ags3.12745","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>We explored institutional factors in Japan associated with lower operative mortality and failure-to-rescue (FTR) rates for eight major gastrointestinal procedures.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A 22-item online questionnaire was sent to 2119 institutional departments (IDs) to examine the association between institutional factors and operative mortality and FTR rates. IDs were classified according to the number of annual surgeries, board certification status, and locality. In addition, the top 20% and bottom 20% of IDs were identified based on FTR rates and matched with the results of the questionnaire survey. Factors associated with operative mortality were selected by multivariate analysis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Of the 1083 IDs that responded to the questionnaire, 568 (213 382 patients) were included in the analysis. Operative morbidity, operative mortality, and FTR rates in the top 20% and bottom 20% of IDs were 13.1% and 8.4% (<i>p</i> &lt; 0.001), 0.52% and 4.3% (<i>p</i> &lt; 0.001), and 4.0% and 51.2% (<i>p</i> &lt; 0.001), respectively. Based on the patients' background characteristics, the top 20% of IDs handled more advanced cases. No significant difference in locality was seen between better or worse hospital FTR rates, but fewer esophagectomies, hepatectomies, and pancreatoduodenectomies were performed in depopulated areas. Six items were found to be associated with operative mortality by multivariate logistic analysis. Only 50 (8.8%) IDs met all five factors related to better FTR rates.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The present findings indicate that several hospital factors surrounding surgical treatment, characterized by abundant human resources, are closely related to better postoperative recovery from severe complications.</p>\u0000 </section>\u0000 </div>","PeriodicalId":8030,"journal":{"name":"Annals of Gastroenterological Surgery","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2023-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ags3.12745","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136113993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of a robotic system on intra-abdominal infectious complications after minimally invasive gastrectomy in patients with gastric cancer: A propensity score matching analysis regarding visceral obesity 机器人系统对胃癌患者微创胃切除术后腹腔内感染并发症的影响:关于内脏肥胖的倾向得分匹配分析
IF 2.7 4区 医学 Q1 Medicine Pub Date : 2023-10-11 DOI: 10.1002/ags3.12748
Naoshi Kubo, Katsunobu Sakurai, Tsuyoshi Hasegawa, Yutaka Tamamori, Yasuhito Iseki, Takafumi Nishii, Sadatoshi Shimizu, Toru Inue, Yukio Nishiguchi, Kiyoshi Maeda

Background

The efficacy of robotic gastrectomy (RG) on postoperative complications in patients with gastric cancer (GC) is unclear in terms of the volume of intra-abdominal fat tissue.

Patients and Methods

We enrolled 403 patients with GC who had minimally invasive surgery between January 2015 and July 2022. During this time, 197 RG and 206 laparoscopic gastrectomies (LG) were performed on the study participants. According to the computed tomography scan, patients were defined as having or not having visceral obesity based on the visceral fatty area (VFA). In each high and low VFA group, we compared short-term outcomes between the RG group and LG group.

Results

After PS matching for patients with high VFA, the two groups were well matched, with 71 cases in both the RG and LG groups. The median surgical time in the RG group was significantly longer (420 vs. 365 min, p < 0.001). However, the RG group had a significantly lower rate of severe intra-abdominal infectious complications (IAIC), such as anastomotic leakage, pancreatic fistula, and intra-abdominal abscess (1.4% vs. 15.4%, p = 0.004). However, among the 77 patients with low VFA values, we found no significant difference in the rate of severe IAIC between the two groups (1.1% in the RG group vs. 2.6% in the LG group, p = 1.00).

Conclusion

RG may be a viable alternative to LG because of the lower postoperative IAIC for patients with visceral obesity and GC. However, RG may not benefit non-obese patients.

背景 就腹腔内脂肪组织的体积而言,机器人胃切除术(RG)对胃癌(GC)患者术后并发症的疗效尚不明确。 患者和方法 我们在 2015 年 1 月至 2022 年 7 月期间招募了 403 名接受微创手术的 GC 患者。在此期间,研究对象接受了 197 例 RG 和 206 例腹腔镜胃切除术(LG)。根据计算机断层扫描结果,患者根据内脏脂肪面积(VFA)被定义为内脏肥胖或非内脏肥胖。在每个内脏脂肪面积较高和较低的组别中,我们比较了 RG 组和 LG 组的短期疗效。 结果 在对高内脏脂肪面积患者进行 PS 匹配后,两组的匹配度很高,RG 组和 LG 组都有 71 例。RG 组的中位手术时间明显更长(420 分钟对 365 分钟,P < 0.001)。不过,RG 组出现严重腹腔内感染并发症(IAIC),如吻合口漏、胰瘘和腹腔内脓肿的比例明显较低(1.4% 对 15.4%,P = 0.004)。然而,在 77 例 VFA 值较低的患者中,我们发现两组患者的严重 IAIC 发生率无显著差异(RG 组为 1.1%,LG 组为 2.6%,P = 1.00)。 结论 对于内脏肥胖和 GC 患者来说,RG 可能是 LG 的可行替代方案,因为术后 IAIC 较低。不过,RG 可能不会使非肥胖患者受益。
{"title":"Impact of a robotic system on intra-abdominal infectious complications after minimally invasive gastrectomy in patients with gastric cancer: A propensity score matching analysis regarding visceral obesity","authors":"Naoshi Kubo,&nbsp;Katsunobu Sakurai,&nbsp;Tsuyoshi Hasegawa,&nbsp;Yutaka Tamamori,&nbsp;Yasuhito Iseki,&nbsp;Takafumi Nishii,&nbsp;Sadatoshi Shimizu,&nbsp;Toru Inue,&nbsp;Yukio Nishiguchi,&nbsp;Kiyoshi Maeda","doi":"10.1002/ags3.12748","DOIUrl":"10.1002/ags3.12748","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>The efficacy of robotic gastrectomy (RG) on postoperative complications in patients with gastric cancer (GC) is unclear in terms of the volume of intra-abdominal fat tissue.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Patients and Methods</h3>\u0000 \u0000 <p>We enrolled 403 patients with GC who had minimally invasive surgery between January 2015 and July 2022. During this time, 197 RG and 206 laparoscopic gastrectomies (LG) were performed on the study participants. According to the computed tomography scan, patients were defined as having or not having visceral obesity based on the visceral fatty area (VFA). In each high and low VFA group, we compared short-term outcomes between the RG group and LG group.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>After PS matching for patients with high VFA, the two groups were well matched, with 71 cases in both the RG and LG groups. The median surgical time in the RG group was significantly longer (420 vs. 365 min, <i>p</i> &lt; 0.001). However, the RG group had a significantly lower rate of severe intra-abdominal infectious complications (IAIC), such as anastomotic leakage, pancreatic fistula, and intra-abdominal abscess (1.4% vs. 15.4%, <i>p</i> = 0.004). However, among the 77 patients with low VFA values, we found no significant difference in the rate of severe IAIC between the two groups (1.1% in the RG group vs. 2.6% in the LG group, <i>p</i> = 1.00).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>RG may be a viable alternative to LG because of the lower postoperative IAIC for patients with visceral obesity and GC. However, RG may not benefit non-obese patients.</p>\u0000 </section>\u0000 </div>","PeriodicalId":8030,"journal":{"name":"Annals of Gastroenterological Surgery","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2023-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ags3.12748","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136064043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Annals of Gastroenterological Surgery
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1