Pub Date : 2024-08-24DOI: 10.1016/j.apmt.2024.102396
Miaomiao Zou, Hongye Guo, Qicheng Zhang, Huijiang Wang, Zehao Ji, Christos Margadji, Kerr Samson, Andi Kuswoyo, Fabrizio Scarpa, Mohand Saed, Sebastian W. Pattinson
Shear-stiffening gels are flexible materials whose modulus is significantly increased upon rapid impact. They have applications in protective and other devices but are generally limited by difficult processability and poor shape retention. Here we demonstrate a simple and scalable process for making elastic shear-stiffening composites with locally controllable and complex geometries. We construct elastic shear-stiffening composites combining mechanical integrity with shear-stiffening behaviour and elasticity. Shear-stiffening gels were 3D-printed as thin fibres with interstitial spaces filled with polydimethylsiloxane elastomer to hold the gels in place. The composite exhibits strong impact-resistance and shape recovery, which may be due to synergistic energy absorption and dissipation at the composite interface, as well as to the elastomer architecture. Composite mechanics can also be locally modulated by tuning the infill percentages to selectively vary part stiffness and therefore aid motion and wearer comfort. Similarly, a composite hinge exhibits excellent damping, shown in a robotic demonstration.
{"title":"Elastic shear-stiffening composites with locally tunable mechanics for protection and damping","authors":"Miaomiao Zou, Hongye Guo, Qicheng Zhang, Huijiang Wang, Zehao Ji, Christos Margadji, Kerr Samson, Andi Kuswoyo, Fabrizio Scarpa, Mohand Saed, Sebastian W. Pattinson","doi":"10.1016/j.apmt.2024.102396","DOIUrl":"https://doi.org/10.1016/j.apmt.2024.102396","url":null,"abstract":"Shear-stiffening gels are flexible materials whose modulus is significantly increased upon rapid impact. They have applications in protective and other devices but are generally limited by difficult processability and poor shape retention. Here we demonstrate a simple and scalable process for making elastic shear-stiffening composites with locally controllable and complex geometries. We construct elastic shear-stiffening composites combining mechanical integrity with shear-stiffening behaviour and elasticity. Shear-stiffening gels were 3D-printed as thin fibres with interstitial spaces filled with polydimethylsiloxane elastomer to hold the gels in place. The composite exhibits strong impact-resistance and shape recovery, which may be due to synergistic energy absorption and dissipation at the composite interface, as well as to the elastomer architecture. Composite mechanics can also be locally modulated by tuning the infill percentages to selectively vary part stiffness and therefore aid motion and wearer comfort. Similarly, a composite hinge exhibits excellent damping, shown in a robotic demonstration.","PeriodicalId":8066,"journal":{"name":"Applied Materials Today","volume":"108 1","pages":""},"PeriodicalIF":8.3,"publicationDate":"2024-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142178288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The clinical treatment of cranial defect reconstruction using hydrogels faces challenges such as inadequate biomechanical strength and limited biofunctional effects. In this study, we have addressed these issues by developing a novel hydrogel. This hydrogel composes desferrioxamine-modified laponite nanoplatelets (LAP/DFO) combined with tannin-modified poly(vinyl alcohol) (PVA/TA), aiming to closely emulate the natural organic-inorganic bony matrix. Our results indicated that the multifunctional hydrogel system, particularly when incorporating LAP/DFO (referred to as PL10), could form a highly ordered porous structure, achieve appropriate biomechanical strength, and release bioactive factors as expected. This system enhanced the adhesion and proliferation of human umbilical vein endothelial cells (HUVECs) for angiogenesis and promoted mesenchymal stem cells (MSCs) osteogenic differentiation for osteogenesis . Moreover, investigations confirmed the efficacy of the multifunctional hydrogels, particularly PL10, in enhancing bone regeneration compared to blank PVA. Collectively, this study contributes valuable insights into the design of bioactive factor delivery systems and offers efficient therapeutic strategies for promoting the repair of cranial defects.
{"title":"Facile design of biofunctionalized nanocomposite hydrogel to potentiate angiogenesis and osteogenesis for the skull regeneration","authors":"Maowen Chen, Rui Yu, Caiyun Mu, Zijian Wang, Jiajie Li, Xinkun Shen, Ye He, Biao Cai, Xudong Zheng","doi":"10.1016/j.apmt.2024.102401","DOIUrl":"https://doi.org/10.1016/j.apmt.2024.102401","url":null,"abstract":"The clinical treatment of cranial defect reconstruction using hydrogels faces challenges such as inadequate biomechanical strength and limited biofunctional effects. In this study, we have addressed these issues by developing a novel hydrogel. This hydrogel composes desferrioxamine-modified laponite nanoplatelets (LAP/DFO) combined with tannin-modified poly(vinyl alcohol) (PVA/TA), aiming to closely emulate the natural organic-inorganic bony matrix. Our results indicated that the multifunctional hydrogel system, particularly when incorporating LAP/DFO (referred to as PL10), could form a highly ordered porous structure, achieve appropriate biomechanical strength, and release bioactive factors as expected. This system enhanced the adhesion and proliferation of human umbilical vein endothelial cells (HUVECs) for angiogenesis and promoted mesenchymal stem cells (MSCs) osteogenic differentiation for osteogenesis . Moreover, investigations confirmed the efficacy of the multifunctional hydrogels, particularly PL10, in enhancing bone regeneration compared to blank PVA. Collectively, this study contributes valuable insights into the design of bioactive factor delivery systems and offers efficient therapeutic strategies for promoting the repair of cranial defects.","PeriodicalId":8066,"journal":{"name":"Applied Materials Today","volume":"80 1","pages":""},"PeriodicalIF":8.3,"publicationDate":"2024-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142178289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Multidrug resistance (MDR) of cancer is the most common obstacle to chemotherapy. Many complex multifunctional nanoparticles have been developed for combination of two or more therapeutics to overcome MDR. Unlike these sophisticated nanoparticles, hydroxyapatite nanoparticles (HAPNs) were found to be able to inhibit cell proliferation of various human cancer cells. Herein, with different MDR cells and chemotherapeutic drugs, we tested whether HAPNs can be widely applied in fighting cancer drug resistance. Rod-shaped HAPNs were synthesized by the aqueous precipitation and then successfully loaded with paclitaxel (PTX) and doxorubicin (DOX) by physical adsorption to obtain pH-responsive drug-loaded nanoparticles, PHAPNs and DHAPNs, respectively. Plain HAPNs exhibited selective cytotoxicity to drug-resistant breast cancer cells MCF-7/ADR, lung cancer cells H69AR and A549/PTX, while spared normal human liver cells L-02. HAPN treatment led to an increase in the apoptosis ratio, a decrease in cell viability and a sustained increase in intracellular calcium ion level in MDR cells. Furthermore, HAPNs facilitated the delivery and accumulation of both drugs, thereby improving the DOX-induced DNA damage in H69AR cells, as well as the acetylation of α-tubulin and cell cycle arrest led by PTX in MCF-7/ADR and A549/PTX cells. Drug-loaded HAPNs greatly enhanced mitochondrial damage, inhibited ATP synthesis and efflux pump activity, and triggered both the intrinsic and extrinsic apoptosis induced by HAPNs or drugs alone. HAPNs acted synergistically with DOX and PTX, resulting in a >6-fold reduction in the IC compared with free drugs for these MDR cells. Notably, PHAPNs successfully suppressed the tumor growth in A549/PTX xenograft mice and exhibited excellent biocompatibility in vivo. These findings demonstrated that HAPNs may be widely utilized to reverse the resistance of various drug-resistant cells, providing a simple but practical approach to overcome MDR of cancer.
{"title":"Safe, simple and multifunctional hydroxyapatite nanoparticles for efficient overcoming of tumor multidrug resistance","authors":"Tao Shen, Hao Wang, Shuiquan Zhang, Xiulin Dong, Wen Zhang, Changsheng Liu, Jiangchao Qian","doi":"10.1016/j.apmt.2024.102394","DOIUrl":"https://doi.org/10.1016/j.apmt.2024.102394","url":null,"abstract":"Multidrug resistance (MDR) of cancer is the most common obstacle to chemotherapy. Many complex multifunctional nanoparticles have been developed for combination of two or more therapeutics to overcome MDR. Unlike these sophisticated nanoparticles, hydroxyapatite nanoparticles (HAPNs) were found to be able to inhibit cell proliferation of various human cancer cells. Herein, with different MDR cells and chemotherapeutic drugs, we tested whether HAPNs can be widely applied in fighting cancer drug resistance. Rod-shaped HAPNs were synthesized by the aqueous precipitation and then successfully loaded with paclitaxel (PTX) and doxorubicin (DOX) by physical adsorption to obtain pH-responsive drug-loaded nanoparticles, PHAPNs and DHAPNs, respectively. Plain HAPNs exhibited selective cytotoxicity to drug-resistant breast cancer cells MCF-7/ADR, lung cancer cells H69AR and A549/PTX, while spared normal human liver cells L-02. HAPN treatment led to an increase in the apoptosis ratio, a decrease in cell viability and a sustained increase in intracellular calcium ion level in MDR cells. Furthermore, HAPNs facilitated the delivery and accumulation of both drugs, thereby improving the DOX-induced DNA damage in H69AR cells, as well as the acetylation of α-tubulin and cell cycle arrest led by PTX in MCF-7/ADR and A549/PTX cells. Drug-loaded HAPNs greatly enhanced mitochondrial damage, inhibited ATP synthesis and efflux pump activity, and triggered both the intrinsic and extrinsic apoptosis induced by HAPNs or drugs alone. HAPNs acted synergistically with DOX and PTX, resulting in a >6-fold reduction in the IC compared with free drugs for these MDR cells. Notably, PHAPNs successfully suppressed the tumor growth in A549/PTX xenograft mice and exhibited excellent biocompatibility in vivo. These findings demonstrated that HAPNs may be widely utilized to reverse the resistance of various drug-resistant cells, providing a simple but practical approach to overcome MDR of cancer.","PeriodicalId":8066,"journal":{"name":"Applied Materials Today","volume":"10 1","pages":""},"PeriodicalIF":8.3,"publicationDate":"2024-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142178414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-08-22DOI: 10.1016/j.apmt.2024.102393
Xinran Liu, Zongmin Xia, Yanzhu Wang, Dan Luo, Zhou Li, Zhaoxu Meng, He Lian
The trace element zinc is often referred to as “the electric spark of life”. The reported physiological roles of zinc as a doping element in a variety of novel bioactive materials include promoting osteogenesis, improving antimicrobial activity, affecting blood coagulation, and inducing anticancer properties, while maintaining good biocompatibility and biodegradability. This review outlines the fundamental physiological mechanisms of zinc activity and provides a detailed overview of the material composition, characterization techniques, and application prospects of zinc-doped bioactive glasses (melt-derived and sol-gel methods), and bioceramics (including bioactive cements and coatings) reported in recent years. The key finding is that the adding zinc to various bioactive materials significantly enhances the versatility and flexibility of applications, such as bone tissue engineering, antibacterial implants and wound hemostasis. In addition, it is worth noting there is still room for improvement in achieving precise delivery and controlled release of zinc ions from the materials, ensuring a balance between therapeutic efficacy and safety of bioactive materials. In a word, this review aspires to summarize the advancements in the osteogenesis, antibacterial and hemostatic applications of metal-doped inorganic bioactive materials and provide guidance for the design and development of innovative bioactive materials in biomedical field. This review provides an in-depth review of the properties and applications of zinc-doped inorganic bioactive materials, including bioactive glasses (melt-derived and sol-gel methods), bioceramics, biocements, and bio-coatings. The key finding is that the adding zinc to various bioactive materials not only enhances the mechanical properties of the materials, but also significantly increases the versatility and flexibility of bone tissue engineering applications by promoting excellent osteogenesis, inhibiting bacterial growth, and promoting good hemostasis through multiple biological mechanisms. Furthermore, it is important to consider the advancements achieved through the use of zinc ions in the study of diabetes microenvironment osteogenesis, Alzheimer's disease (AD), atherosclerosis, and other areas. This will help in exploring wider applications of zinc and in addressing current technical constraints to create novel zinc-doped biomaterials and therapeutics.
{"title":"Zinc-doped inorganic bioactive materials: a comprehensive review of properties and their applications in osteogenesis, antibacterial, and hemostasis","authors":"Xinran Liu, Zongmin Xia, Yanzhu Wang, Dan Luo, Zhou Li, Zhaoxu Meng, He Lian","doi":"10.1016/j.apmt.2024.102393","DOIUrl":"https://doi.org/10.1016/j.apmt.2024.102393","url":null,"abstract":"The trace element zinc is often referred to as “the electric spark of life”. The reported physiological roles of zinc as a doping element in a variety of novel bioactive materials include promoting osteogenesis, improving antimicrobial activity, affecting blood coagulation, and inducing anticancer properties, while maintaining good biocompatibility and biodegradability. This review outlines the fundamental physiological mechanisms of zinc activity and provides a detailed overview of the material composition, characterization techniques, and application prospects of zinc-doped bioactive glasses (melt-derived and sol-gel methods), and bioceramics (including bioactive cements and coatings) reported in recent years. The key finding is that the adding zinc to various bioactive materials significantly enhances the versatility and flexibility of applications, such as bone tissue engineering, antibacterial implants and wound hemostasis. In addition, it is worth noting there is still room for improvement in achieving precise delivery and controlled release of zinc ions from the materials, ensuring a balance between therapeutic efficacy and safety of bioactive materials. In a word, this review aspires to summarize the advancements in the osteogenesis, antibacterial and hemostatic applications of metal-doped inorganic bioactive materials and provide guidance for the design and development of innovative bioactive materials in biomedical field. This review provides an in-depth review of the properties and applications of zinc-doped inorganic bioactive materials, including bioactive glasses (melt-derived and sol-gel methods), bioceramics, biocements, and bio-coatings. The key finding is that the adding zinc to various bioactive materials not only enhances the mechanical properties of the materials, but also significantly increases the versatility and flexibility of bone tissue engineering applications by promoting excellent osteogenesis, inhibiting bacterial growth, and promoting good hemostasis through multiple biological mechanisms. Furthermore, it is important to consider the advancements achieved through the use of zinc ions in the study of diabetes microenvironment osteogenesis, Alzheimer's disease (AD), atherosclerosis, and other areas. This will help in exploring wider applications of zinc and in addressing current technical constraints to create novel zinc-doped biomaterials and therapeutics.","PeriodicalId":8066,"journal":{"name":"Applied Materials Today","volume":"46 1","pages":""},"PeriodicalIF":8.3,"publicationDate":"2024-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142178326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
In order to ensure the high-temperature reliability of device in high temperature service, a new sintered structure layer, nano-Ag paste filling graphene reinforced Ni foam, was designed to realize the chip packaging in this work. This layer had excellent reliability and high-temperature heat dissipation stability, which benefit from the higher proportion of low-angle grain boundaries, finer grains and excellent heat dissipation capacity of graphene. The foam structure had favorable stress release effect, which made the sintered layer had high service reliability. The excellent heat dissipation ability of graphene overcomes the inherent defect of slow heat dissipation of the device under high temperature environment.
{"title":"Improving thermal stability and reliability of power chips by sintering foam structure layer","authors":"Guanda Qu, Wei Guo, Cheng Zhang, Junliang Xue, Zilong Peng, Changhao Yin, Siliang He, Guisheng Zou, Qiang Jia, Hongqiang Zhang","doi":"10.1016/j.apmt.2024.102397","DOIUrl":"https://doi.org/10.1016/j.apmt.2024.102397","url":null,"abstract":"In order to ensure the high-temperature reliability of device in high temperature service, a new sintered structure layer, nano-Ag paste filling graphene reinforced Ni foam, was designed to realize the chip packaging in this work. This layer had excellent reliability and high-temperature heat dissipation stability, which benefit from the higher proportion of low-angle grain boundaries, finer grains and excellent heat dissipation capacity of graphene. The foam structure had favorable stress release effect, which made the sintered layer had high service reliability. The excellent heat dissipation ability of graphene overcomes the inherent defect of slow heat dissipation of the device under high temperature environment.","PeriodicalId":8066,"journal":{"name":"Applied Materials Today","volume":"6 1","pages":""},"PeriodicalIF":8.3,"publicationDate":"2024-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142178290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-08-21DOI: 10.1016/j.apmt.2024.102399
Moaaz Abdelhamid, Carolina Corzo, Jesús Alberto Afonso Urich, Eyke Slama, Eleonore Fröhlich, Dirk Lochmann, Sebastian Reyer, Tanja Freichel, Martin Spoerk, Sharareh Salar-Behzadi
While filament-based 3D-printing (3DP) is the most utilized 3DP technology in the pharmaceutical field, it has not been demonstrated for processing of drug-loaded lipid-based formulations. This work exploits hexa-glycerol ester of palmitic acid (Pg6-C16-P) as an advanced lipid material, loaded with felodipine as a poorly soluble model drug, for fabricating novel oral solid dosage forms (OSDFs) via filament-based 3D-printing. After material melt-blending, the formulation was extruded using the liquid feeding approach to obtain a mechanically manageable, and hence 3D-printable, drug-loaded lipid filament. The fabrication of geometries with variable infill densities was demonstrated. The extent of infill density was found to significantly impact the optimal printing parameters required to achieve the desired shape. The solid-state analysis confirmed the amorphous state of felodipine after 3DP. The release rate of the drug was studied via dissolution test and showed to be tunable based on the tablet geometry. It was also possible to tailor the design of the dosage form to perform similarly to a commercial product. The formulation was evidenced as safe via toxicity studies with improved felodipine solubility. This study establishes filament-based 3DP as an alternative platform viable for fabricating advanced lipid-based OSDFs, and concurrently, promotes Pg6-C16-P as a promising and high performing 3DP lipid material for drug delivery.
{"title":"Personalization of lipid-based oral dosage forms via filament-based 3D-printing","authors":"Moaaz Abdelhamid, Carolina Corzo, Jesús Alberto Afonso Urich, Eyke Slama, Eleonore Fröhlich, Dirk Lochmann, Sebastian Reyer, Tanja Freichel, Martin Spoerk, Sharareh Salar-Behzadi","doi":"10.1016/j.apmt.2024.102399","DOIUrl":"https://doi.org/10.1016/j.apmt.2024.102399","url":null,"abstract":"While filament-based 3D-printing (3DP) is the most utilized 3DP technology in the pharmaceutical field, it has not been demonstrated for processing of drug-loaded lipid-based formulations. This work exploits hexa-glycerol ester of palmitic acid (Pg6-C16-P) as an advanced lipid material, loaded with felodipine as a poorly soluble model drug, for fabricating novel oral solid dosage forms (OSDFs) via filament-based 3D-printing. After material melt-blending, the formulation was extruded using the liquid feeding approach to obtain a mechanically manageable, and hence 3D-printable, drug-loaded lipid filament. The fabrication of geometries with variable infill densities was demonstrated. The extent of infill density was found to significantly impact the optimal printing parameters required to achieve the desired shape. The solid-state analysis confirmed the amorphous state of felodipine after 3DP. The release rate of the drug was studied via dissolution test and showed to be tunable based on the tablet geometry. It was also possible to tailor the design of the dosage form to perform similarly to a commercial product. The formulation was evidenced as safe via toxicity studies with improved felodipine solubility. This study establishes filament-based 3DP as an alternative platform viable for fabricating advanced lipid-based OSDFs, and concurrently, promotes Pg6-C16-P as a promising and high performing 3DP lipid material for drug delivery.","PeriodicalId":8066,"journal":{"name":"Applied Materials Today","volume":"17 1","pages":""},"PeriodicalIF":8.3,"publicationDate":"2024-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142178291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Rheumatoid arthritis (RA) is a common autoimmune disease, and the abnormal proliferation of fibroblast-like synoviocytes (FLSs) in inflamed joints plays a key role in the pathogenesis of RA, which has become an important therapeutic target for RA treatment. This work reported a facilely formulated nanoparticle from saponin (Sap) and dexamethasone (Dex) in precise ratio, affording the resultant Dex@Sap nanoparticles. Benefiting from the enlargement of vascular endothelial cell gap at the inflammation site and intra-articular injection, Dex@Sap could accumulate at the inflamed joints to inhibit excessive proliferation of FLSs and mediate cell apoptosis, achieving symptomatic relief and efficient RA treatment, while reducing the amount of drug needed as well as the occurrence of adverse reactions. Typical AKT (also known as protein kinase B, PKB)/mTOR (mammalian target of rapamycin) pathway was observed to be inhibited, and the mitochondria-mediated intracellular reactive oxygen species (ROS) level was also upregulated by Dex@Sap. Further evaluations demonstrated that Dex@Sap could significantly alleviate RA-induced inflammatory response and the expression of pro-inflammatory cytokines to cure joint damage in collagen-induced arthritis mice and rats. This work provides a clinically promising nanomedicine to synergistically treat RA.
类风湿性关节炎（RA）是一种常见的自身免疫性疾病，炎症关节中纤维母细胞样滑膜细胞（FLS）的异常增殖在RA的发病机制中起着关键作用，已成为RA治疗的重要靶点。这项研究报告了一种由皂苷（Sap）和地塞米松（Dex）按精确比例配制而成的纳米颗粒，即 Dex@Sap 纳米颗粒。利用炎症部位血管内皮细胞间隙的扩大和关节内注射，Dex@Sap 可在炎症关节处聚集，抑制 FLSs 过度增殖并介导细胞凋亡，从而达到缓解症状、高效治疗 RA 的目的，同时减少用药量和不良反应的发生。据观察，Dex@Sap抑制了典型的AKT（又称蛋白激酶B，PKB）/mTOR（哺乳动物雷帕霉素靶标）通路，同时还上调了线粒体介导的细胞内活性氧（ROS）水平。进一步的评估表明，Dex@Sap 能明显减轻 RA 诱导的炎症反应和促炎细胞因子的表达，从而治疗胶原诱导的关节炎小鼠和大鼠的关节损伤。这项工作为协同治疗 RA 提供了一种具有临床前景的纳米药物。
{"title":"Rational formulation of saponin and dexamethasone for the synergistic treatment of rheumatoid arthritis in vivo","authors":"Yaru Yue, Zhengquan Liao, Yingqian Zhou, Yongteng Zhang, Zeshu Wang, Shengtao Wang, Xianglong Hu, Quan Zhou","doi":"10.1016/j.apmt.2024.102381","DOIUrl":"https://doi.org/10.1016/j.apmt.2024.102381","url":null,"abstract":"Rheumatoid arthritis (RA) is a common autoimmune disease, and the abnormal proliferation of fibroblast-like synoviocytes (FLSs) in inflamed joints plays a key role in the pathogenesis of RA, which has become an important therapeutic target for RA treatment. This work reported a facilely formulated nanoparticle from saponin (Sap) and dexamethasone (Dex) in precise ratio, affording the resultant Dex@Sap nanoparticles. Benefiting from the enlargement of vascular endothelial cell gap at the inflammation site and intra-articular injection, Dex@Sap could accumulate at the inflamed joints to inhibit excessive proliferation of FLSs and mediate cell apoptosis, achieving symptomatic relief and efficient RA treatment, while reducing the amount of drug needed as well as the occurrence of adverse reactions. Typical AKT (also known as protein kinase B, PKB)/mTOR (mammalian target of rapamycin) pathway was observed to be inhibited, and the mitochondria-mediated intracellular reactive oxygen species (ROS) level was also upregulated by Dex@Sap. Further evaluations demonstrated that Dex@Sap could significantly alleviate RA-induced inflammatory response and the expression of pro-inflammatory cytokines to cure joint damage in collagen-induced arthritis mice and rats. This work provides a clinically promising nanomedicine to synergistically treat RA.","PeriodicalId":8066,"journal":{"name":"Applied Materials Today","volume":"10 1","pages":""},"PeriodicalIF":8.3,"publicationDate":"2024-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142178313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The management of osteosarcoma presents a significant challenge, and the creation of an intelligent synergistic drug delivery system is broadly acknowledged as a promising approach to therapy. Hence, in this study, a temperature-sensitive hydrogel containing DOX-loaded and folic acid-modified BPNSs that can be injected was developed to enable drug release via a pH/NIR response, aimed at synergistic photothermal‒chemotherapeutic treatment of osteosarcoma. The active targeting of BPNSs-PEG-FA/DOX involved liquid-phase stripping and electrostatic adsorption, leading to the preparation of the BPNSs-PEG-FA/DOX aqueous dispersion hybrid hydrogel matrix as a BPNSs-PEG-FA/DOX@Hydrogel through a cold method. This composite hydrogel exhibits favorable through-needle properties, superior photothermal conversion efficiency, pH/NIR intelligent responsiveness, and controlled delayed-release drug release capabilities, along with favorable in vitro cellular biocompatibility. It also demonstrates effective in vitro and in vivo active targeting, controlled delayed release, and synergistic photothermal-chemotherapeutic anti-osteosarcoma activity, showing considerable promise for the treatment of superficial tumors such as osteosarcoma.
{"title":"Construction and evaluation of a folate-mediated adriamycin phosphorene thermosensitive hydrogel delivery system against osteosarcoma","authors":"Zhou Zhang, Jun-yi Yang, Jia-han Chen, Hua Zhang, Xing Tian, Yang Liu, Yong-sheng Li, Feng Yu, Wen Chen","doi":"10.1016/j.apmt.2024.102386","DOIUrl":"https://doi.org/10.1016/j.apmt.2024.102386","url":null,"abstract":"The management of osteosarcoma presents a significant challenge, and the creation of an intelligent synergistic drug delivery system is broadly acknowledged as a promising approach to therapy. Hence, in this study, a temperature-sensitive hydrogel containing DOX-loaded and folic acid-modified BPNSs that can be injected was developed to enable drug release via a pH/NIR response, aimed at synergistic photothermal‒chemotherapeutic treatment of osteosarcoma. The active targeting of BPNSs-PEG-FA/DOX involved liquid-phase stripping and electrostatic adsorption, leading to the preparation of the BPNSs-PEG-FA/DOX aqueous dispersion hybrid hydrogel matrix as a BPNSs-PEG-FA/DOX@Hydrogel through a cold method. This composite hydrogel exhibits favorable through-needle properties, superior photothermal conversion efficiency, pH/NIR intelligent responsiveness, and controlled delayed-release drug release capabilities, along with favorable in vitro cellular biocompatibility. It also demonstrates effective in vitro and in vivo active targeting, controlled delayed release, and synergistic photothermal-chemotherapeutic anti-osteosarcoma activity, showing considerable promise for the treatment of superficial tumors such as osteosarcoma.","PeriodicalId":8066,"journal":{"name":"Applied Materials Today","volume":"10 1","pages":""},"PeriodicalIF":8.3,"publicationDate":"2024-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142178314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-08-19DOI: 10.1016/j.apmt.2024.102352
R. Brito-Pereira, C. Ribeiro, A. García Díez, V.F. Cardoso, Catherine Klapperich, S. Lanceros-Mendez, P. Martins
Anthropogenic magnetite (AM) nanoparticles have been identified in the human brain and circulatory system, potentially linked to neurodegenerative and cardiovascular diseases. Specifically, AM and other magnetic nanocontaminants from industrial emissions and brake wear are hazardous components of particulate matter. Such contamination enriches urban soils with magnetite and other magnetic nanocontaminants, which can be absorbed by plants like rice and consequently enter the human body indirectly. Developing accurate and robust AM-sensing platforms is crucial, especially in areas where magnetic contamination threatens ecosystems and human health. Innovative materials, such as magnetoactive smart materials, are essential for creating sensors with specific, wireless, and adjustable magnetic properties for efficient detection and monitoring of soil contamination. This study presents an origami-based multifunctional sensing platform for sustainable detection of magnetic environmental contamination. Utilizing paper as its substrate for low-cost AM sensing, the device incorporates two wax/NdFeB magnets, four hydrophilic channels, and a hydrophilic analysis area, enclosed by hydrophobic wax. Through comprehensive analysis techniques including energy-dispersive X-ray spectroscopy, vibrating sample magnetometry, infrared spectroscopy, and photographic color changes, the device exhibited a detection limit below 156 μg. The platform's versatility, affordability, sustainability, and capacity for multi-analysis indicate promising prospects for developing economically equitable, user-friendly, mechanically robust, and flexible magnetic contamination sensing devices. These devices eliminate the need for complex machinery while delivering rapid, accurate, and precise results tailored to diverse environmental needs, thus promoting sustainable and safe societies.
在人类大脑和循环系统中发现了人为磁铁矿（AM）纳米粒子，可能与神经退行性疾病和心血管疾病有关。具体来说，工业排放和制动器磨损产生的 AM 和其他磁性纳米污染物是微粒物质的有害成分。这种污染使城市土壤中富含磁铁矿和其他磁性纳米污染物，可被水稻等植物吸收，从而间接进入人体。开发精确、强大的 AM 传感平台至关重要，尤其是在磁污染威胁生态系统和人类健康的地区。创新材料，如磁活性智能材料，对于创建具有特定、无线和可调磁性能的传感器以有效检测和监测土壤污染至关重要。本研究介绍了一种基于折纸的多功能传感平台，用于可持续地检测磁性环境污染。该装置利用纸张作为低成本 AM 传感的基底，包含两个蜡/钕铁硼磁体、四个亲水通道和一个亲水分析区，并由疏水性蜡封闭。通过综合分析技术，包括能量色散 X 射线光谱法、振动样品磁力测定法、红外光谱法和照相颜色变化法，该装置的检测限低于 156 微克。该平台的多功能性、经济性、可持续性和多重分析能力，为开发经济公平、用户友好、机械坚固和灵活的磁污染传感装置带来了广阔的前景。这些装置无需复杂的机械设备，可根据不同的环境需求提供快速、准确和精确的结果，从而促进社会的可持续发展和安全。
{"title":"Origami-based multifunctional sensing platform for sustainable detection of hazardous magnetic materials","authors":"R. Brito-Pereira, C. Ribeiro, A. García Díez, V.F. Cardoso, Catherine Klapperich, S. Lanceros-Mendez, P. Martins","doi":"10.1016/j.apmt.2024.102352","DOIUrl":"https://doi.org/10.1016/j.apmt.2024.102352","url":null,"abstract":"Anthropogenic magnetite (AM) nanoparticles have been identified in the human brain and circulatory system, potentially linked to neurodegenerative and cardiovascular diseases. Specifically, AM and other magnetic nanocontaminants from industrial emissions and brake wear are hazardous components of particulate matter. Such contamination enriches urban soils with magnetite and other magnetic nanocontaminants, which can be absorbed by plants like rice and consequently enter the human body indirectly. Developing accurate and robust AM-sensing platforms is crucial, especially in areas where magnetic contamination threatens ecosystems and human health. Innovative materials, such as magnetoactive smart materials, are essential for creating sensors with specific, wireless, and adjustable magnetic properties for efficient detection and monitoring of soil contamination. This study presents an origami-based multifunctional sensing platform for sustainable detection of magnetic environmental contamination. Utilizing paper as its substrate for low-cost AM sensing, the device incorporates two wax/NdFeB magnets, four hydrophilic channels, and a hydrophilic analysis area, enclosed by hydrophobic wax. Through comprehensive analysis techniques including energy-dispersive X-ray spectroscopy, vibrating sample magnetometry, infrared spectroscopy, and photographic color changes, the device exhibited a detection limit below 156 μg. The platform's versatility, affordability, sustainability, and capacity for multi-analysis indicate promising prospects for developing economically equitable, user-friendly, mechanically robust, and flexible magnetic contamination sensing devices. These devices eliminate the need for complex machinery while delivering rapid, accurate, and precise results tailored to diverse environmental needs, thus promoting sustainable and safe societies.","PeriodicalId":8066,"journal":{"name":"Applied Materials Today","volume":"16 1","pages":""},"PeriodicalIF":8.3,"publicationDate":"2024-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142178315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Oral mucosal lesions, prevalent and multifactorial disorders characterized by immune dysfunction and infection, pose significant challenges to oral functions due to the lack of effective and safe treatments. We herein introduce a multifunctional microneedle patch (MMP) that uniquely combines bone marrow mesenchymal stem cell-derived exosomes (Exos) and folic acid-magnetic nanoparticles (Fmns) within a methacrylated carboxymethyl chitosan (CMCSMA) microneedle structure. This innovative design synergistically enhances therapeutic outcomes by promoting immune regulation, angiogenesis, and epithelial repair. The MMP also features a gelatin layer for rapid pain relief local anesthetic release and provides antimicrobial protection against opportunistic pathogens, reducing secondary infection risks. and results showed significant improvements in wound closure rates, re-epithelialization, and angiogenesis compared to control treatments. Additionally, the MMP effectively modulated immune responses, reducing inflammatory cytokine levels and promoting macrophage polarization towards a pro-healing phenotype. These findings demonstrate the efficacy and biosafety of the MMP, and highlight its potential to address critical clinical challenges in treating oral mucosal lesions, offering a multifunctional approach that integrates immune modulation, infection control, and regenerative therapy.
{"title":"A multifunctional microneedle patch loading exosomes and magnetic nanoparticles synergistically for treating oral mucosal lesions","authors":"Fanfan Chen, Zifan Zhao, Xinyi Liu, Hu Chen, Lihua An, Yuan Wang, Weisi Xu, Suli Guo, Songlun Jiang, Guo-Qiang Chen, Yuchun Sun, Xu Zhang","doi":"10.1016/j.apmt.2024.102382","DOIUrl":"https://doi.org/10.1016/j.apmt.2024.102382","url":null,"abstract":"Oral mucosal lesions, prevalent and multifactorial disorders characterized by immune dysfunction and infection, pose significant challenges to oral functions due to the lack of effective and safe treatments. We herein introduce a multifunctional microneedle patch (MMP) that uniquely combines bone marrow mesenchymal stem cell-derived exosomes (Exos) and folic acid-magnetic nanoparticles (Fmns) within a methacrylated carboxymethyl chitosan (CMCSMA) microneedle structure. This innovative design synergistically enhances therapeutic outcomes by promoting immune regulation, angiogenesis, and epithelial repair. The MMP also features a gelatin layer for rapid pain relief local anesthetic release and provides antimicrobial protection against opportunistic pathogens, reducing secondary infection risks. and results showed significant improvements in wound closure rates, re-epithelialization, and angiogenesis compared to control treatments. Additionally, the MMP effectively modulated immune responses, reducing inflammatory cytokine levels and promoting macrophage polarization towards a pro-healing phenotype. These findings demonstrate the efficacy and biosafety of the MMP, and highlight its potential to address critical clinical challenges in treating oral mucosal lesions, offering a multifunctional approach that integrates immune modulation, infection control, and regenerative therapy.","PeriodicalId":8066,"journal":{"name":"Applied Materials Today","volume":"108 1","pages":""},"PeriodicalIF":8.3,"publicationDate":"2024-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142178320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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