An impedance-based electrochemical immunosensor for direct and binder-free target recognition of carbohydrate antigen (CA 19-9) tumor biomarker for the early diagnosis of pancreatic cancer was reported. This study uses an in situ solvothermal process to develop a simple method for the one-pot construction of Ni-Fe heteroMOFs (HFNMOFs,) self-supported on conductive nickel foam (NicFm). Utilizing HFNMOFs@NicFm developed in this study, the electrochemical performance of the biosensor was studied for the first time. The as-prepared mixed MOFs decorated NicFm electrodes displayed potential electrochemical outputs. They demonstrated the potential for developing binder-free non-enzymatic immunosensors with wide linear limits, high selectivity, stability, and excellent sensitivity. The bifunctional MOFs exhibit improved electrochemical conductivity owing to the highly exposed metal sites and hierarchical porosity. The changes in the charge transfer resistance present a linear response against increasing target concentrations. The immunosensor developed in this study exhibited its detection limit of 2.56 U/mL. Further, the bioelectrodes produced were validated against real human spiked serum with good results of percentage recovery, indicating the immunosensor is well-suitable to be tested in real-time analysis.
{"title":"Impedimetric identification of heteroMOFs modified porous nickel foam self-supports as robust electrodes for CA 19-9 pancreatic tumor marker in human serum","authors":"Sathyadevi Palanisamy, Priya Vijayaraghavan, Tsu-Yin Cheng, Sarin Kumar Kappithottam, Duraisamy Senthil Raja, Xiao-Qi Chen, Tsai-Te Lu, Chiao-Yun Chen, Yun-Ming Wang","doi":"10.1016/j.apmt.2024.102375","DOIUrl":"https://doi.org/10.1016/j.apmt.2024.102375","url":null,"abstract":"An impedance-based electrochemical immunosensor for direct and binder-free target recognition of carbohydrate antigen (CA 19-9) tumor biomarker for the early diagnosis of pancreatic cancer was reported. This study uses an in situ solvothermal process to develop a simple method for the one-pot construction of Ni-Fe heteroMOFs (HFNMOFs,) self-supported on conductive nickel foam (NicFm). Utilizing HFNMOFs@NicFm developed in this study, the electrochemical performance of the biosensor was studied for the first time. The as-prepared mixed MOFs decorated NicFm electrodes displayed potential electrochemical outputs. They demonstrated the potential for developing binder-free non-enzymatic immunosensors with wide linear limits, high selectivity, stability, and excellent sensitivity. The bifunctional MOFs exhibit improved electrochemical conductivity owing to the highly exposed metal sites and hierarchical porosity. The changes in the charge transfer resistance present a linear response against increasing target concentrations. The immunosensor developed in this study exhibited its detection limit of 2.56 U/mL. Further, the bioelectrodes produced were validated against real human spiked serum with good results of percentage recovery, indicating the immunosensor is well-suitable to be tested in real-time analysis.","PeriodicalId":8066,"journal":{"name":"Applied Materials Today","volume":"84 1","pages":""},"PeriodicalIF":8.3,"publicationDate":"2024-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141931138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-08-05DOI: 10.1016/j.apmt.2024.102371
Quoc-Phu Ma, Hoang-Sy Nguyen, Jiri Hajnys, Jakub Mesicek, Marek Pagac, Jana Petru
This paper delves into the cutting-edge applications of Machine Learning (ML) within modern Additive Manufacturing (AM), employing bibliometric analysis as its methodology. Formulated around three pivotal research questions, the study navigates through the current landscape of the research field. Utilizing data sourced from Web of Science, the paper conducts a comprehensive statistical and visual analysis to unveil underlying patterns within the existing literature. Each category of ML techniques is elucidated alongside its specific applications, providing researchers with a holistic overview of the research terrain and serving as a practical checklist for those seeking to address particular challenges. Culminating in a vision for the Smart Additive Manufacturing Factory (SAMF), the paper envisions seamless integration of reviewed ML techniques. Furthermore, it offers critical insights from a practical standpoint, thereby facilitating shaping future research directions in the field.
本文采用文献计量分析方法，深入探讨了机器学习（ML）在现代增材制造（AM）中的前沿应用。本研究围绕三个关键性研究问题，对该研究领域的现状进行了分析。本文利用从 Web of Science 获取的数据，进行了全面的统计和可视化分析，以揭示现有文献中的潜在模式。每一类 ML 技术的具体应用都得到了阐释，为研究人员提供了研究领域的整体概况，并为那些寻求解决特定挑战的人提供了实用的清单。本文最终提出了智能增材制造工厂（SAMF）的愿景，设想将已审查的 ML 技术进行无缝集成。此外，它还从实用的角度提出了重要见解，从而有助于确定该领域未来的研究方向。
{"title":"A bibliometric review on application of machine learning in additive manufacturing and practical justification","authors":"Quoc-Phu Ma, Hoang-Sy Nguyen, Jiri Hajnys, Jakub Mesicek, Marek Pagac, Jana Petru","doi":"10.1016/j.apmt.2024.102371","DOIUrl":"https://doi.org/10.1016/j.apmt.2024.102371","url":null,"abstract":"This paper delves into the cutting-edge applications of Machine Learning (ML) within modern Additive Manufacturing (AM), employing bibliometric analysis as its methodology. Formulated around three pivotal research questions, the study navigates through the current landscape of the research field. Utilizing data sourced from Web of Science, the paper conducts a comprehensive statistical and visual analysis to unveil underlying patterns within the existing literature. Each category of ML techniques is elucidated alongside its specific applications, providing researchers with a holistic overview of the research terrain and serving as a practical checklist for those seeking to address particular challenges. Culminating in a vision for the Smart Additive Manufacturing Factory (SAMF), the paper envisions seamless integration of reviewed ML techniques. Furthermore, it offers critical insights from a practical standpoint, thereby facilitating shaping future research directions in the field.","PeriodicalId":8066,"journal":{"name":"Applied Materials Today","volume":"76 1","pages":""},"PeriodicalIF":8.3,"publicationDate":"2024-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141931139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-08-05DOI: 10.1016/j.apmt.2024.102359
Mohammad Hammoud, Mohamad Hmadeh, Mohammad Ahmad
The research on sustainable and efficient routes to produce valuable chemicals from renewable biomass has garnered considerable attention in recent years. Among these chemicals, 5-hydroxymethylfurfural (5-HMF) holds significant promise as a versatile platform molecule for various applications in the chemical industry. This study investigates the production of 5-HMF from glucose using zirconium-based metal-organic frameworks (Zr-MOFs) as environmentally friendly catalysts, an alternative to the traditional homogeneous catalysts. UiO-66 and its functionalized derivatives (e.g. UiO-66UiO-66, and UiO-66) were synthesized to study the effect of the functional groups on the dehydration reaction. The synthesized MOFs were fully characterized using powder X-ray diffraction (PXRD), thermogravimetric analysis (TGA), N adsorption-desorption, Infrared spectroscopy (IR), Pyridine-Fourier Transform Infrared spectroscopy (Py-FTIR), and scanning electron microscopy (SEM). The catalytic performance of the synthesized MOFswas evaluated for the dehydration of glucose to 5-HMF in DMSO and further optimized in other monophasic and biphasic systems. Results indicated that UiO-66 exhibited exceptional catalytic activity for the conversion of glucose to HMF, with a significantly higher HMF yield of 44 % compared to other reported MOF catalysts and to that of HSO, which yielded 35 % at a temperature of 140 °C and a 6 h reaction time. This is mainly attributed to the effect of the bifunctional active acid sites of the metal nodes and the functional group of the organic linker (free carboxylic groups), which acted as the main source of Lewis and Brønsted acid sites respectively, compared to UiO-66. Additionally, the results suggested that the catalyst with higher acid density, higher relative mesopority, and a moderate B/L ratio could enhance glucose dehydration regardless of the surface area. Furthermore, the catalyst demonstrated excellent reusability and stability, with a decrease of only 10 % after four reaction cycles. The recycled catalyst revealed no structural alterations in its framework. This study contributes to the growing body of research on Zr-based MOF as a stable and efficient catalyst for glucose valorization to produce 5-HMF under mild reaction conditions.
{"title":"Structural engineering of metal-organic framework catalysts for efficient conversion of glucose into 5-HydroxyMethylFurfural","authors":"Mohammad Hammoud, Mohamad Hmadeh, Mohammad Ahmad","doi":"10.1016/j.apmt.2024.102359","DOIUrl":"https://doi.org/10.1016/j.apmt.2024.102359","url":null,"abstract":"The research on sustainable and efficient routes to produce valuable chemicals from renewable biomass has garnered considerable attention in recent years. Among these chemicals, 5-hydroxymethylfurfural (5-HMF) holds significant promise as a versatile platform molecule for various applications in the chemical industry. This study investigates the production of 5-HMF from glucose using zirconium-based metal-organic frameworks (Zr-MOFs) as environmentally friendly catalysts, an alternative to the traditional homogeneous catalysts. UiO-66 and its functionalized derivatives (e.g. UiO-66UiO-66, and UiO-66) were synthesized to study the effect of the functional groups on the dehydration reaction. The synthesized MOFs were fully characterized using powder X-ray diffraction (PXRD), thermogravimetric analysis (TGA), N adsorption-desorption, Infrared spectroscopy (IR), Pyridine-Fourier Transform Infrared spectroscopy (Py-FTIR), and scanning electron microscopy (SEM). The catalytic performance of the synthesized MOFswas evaluated for the dehydration of glucose to 5-HMF in DMSO and further optimized in other monophasic and biphasic systems. Results indicated that UiO-66 exhibited exceptional catalytic activity for the conversion of glucose to HMF, with a significantly higher HMF yield of 44 % compared to other reported MOF catalysts and to that of HSO, which yielded 35 % at a temperature of 140 °C and a 6 h reaction time. This is mainly attributed to the effect of the bifunctional active acid sites of the metal nodes and the functional group of the organic linker (free carboxylic groups), which acted as the main source of Lewis and Brønsted acid sites respectively, compared to UiO-66. Additionally, the results suggested that the catalyst with higher acid density, higher relative mesopority, and a moderate B/L ratio could enhance glucose dehydration regardless of the surface area. Furthermore, the catalyst demonstrated excellent reusability and stability, with a decrease of only 10 % after four reaction cycles. The recycled catalyst revealed no structural alterations in its framework. This study contributes to the growing body of research on Zr-based MOF as a stable and efficient catalyst for glucose valorization to produce 5-HMF under mild reaction conditions.","PeriodicalId":8066,"journal":{"name":"Applied Materials Today","volume":"51 1","pages":""},"PeriodicalIF":8.3,"publicationDate":"2024-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141931140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-08-03DOI: 10.1016/j.apmt.2024.102374
Li Huang, Zhonglan Yang, Yuan He, Lei Yang, Wangzhong Xiao, Jialuo Cai, Hongqiao Fan, Yilin Xu, Xinhua Xia
Cantharidin (CTD) as a treatment for primary liver cancer are well known, and although structural alteration and nano-delivery are efficient in diminishing toxicity, its urinary and digestive toxicity has hindered its clinical application. Based on the synergistic effect of CTD and baicalin (BA) on proliferation inhibition of liver tumor cells, the highly expressed folic acid (FA) receptor of liver cancer cell membrane and the high negative membrane potential of tumor cell mitochondria, we synthesized CHEMS-FRFK and prepared a dual-ligand modified co-delivery liposomes (FA/FRFK-CTD/BA-Lips). Liposomes were spherical particles with uniform particle size, high encapsulation rate, good stability and no hemolysis. The results confirmed that FA/FRFK-CTD/BA-Lips had good targeting to mitochondria of tumor cells, and its target effect on mitochondria of HepG2 was better than that of Huh-7 cells. Compared with CTD, the cytotoxicity of liposomes on HepG2 is 7.0 times higher, while the cytotoxic effect on normal liver cells Thle-2 is 2.1 times lower. It may be related to increasing clathrin-mediated endocytosis, inhibiting tumor cell migration, arresting cell cycle in G1/G0 phase, and promoting mitochondria-mediated endogenous Bcl-2/Caspase 3 apoptosis pathway. Meanwhile, FA/FRFK-CTD/BA-Lips could alter the pharmacokinetic behavior of CTD and BA by increasing concentrations , slowing release and excretion, good anti-tumor with no obvious toxicity, and successfully delivered CTD/BA to liver tissue, tumor cells and mitochondria. Therefore, FA/FRFK-CTD/BA-Lips, as a delivery system targeting the mitochondria of liver cancer cells, has promising development potential, and could provide a new strategy for solving the problem of CTD toxicity and the treatment of hepatocellular carcinoma.
{"title":"Development of cantharidin/baicalin co-delivery system based on mitochondrial targeting strategy for enhanced hepatocellular carcinoma therapy","authors":"Li Huang, Zhonglan Yang, Yuan He, Lei Yang, Wangzhong Xiao, Jialuo Cai, Hongqiao Fan, Yilin Xu, Xinhua Xia","doi":"10.1016/j.apmt.2024.102374","DOIUrl":"https://doi.org/10.1016/j.apmt.2024.102374","url":null,"abstract":"Cantharidin (CTD) as a treatment for primary liver cancer are well known, and although structural alteration and nano-delivery are efficient in diminishing toxicity, its urinary and digestive toxicity has hindered its clinical application. Based on the synergistic effect of CTD and baicalin (BA) on proliferation inhibition of liver tumor cells, the highly expressed folic acid (FA) receptor of liver cancer cell membrane and the high negative membrane potential of tumor cell mitochondria, we synthesized CHEMS-FRFK and prepared a dual-ligand modified co-delivery liposomes (FA/FRFK-CTD/BA-Lips). Liposomes were spherical particles with uniform particle size, high encapsulation rate, good stability and no hemolysis. The results confirmed that FA/FRFK-CTD/BA-Lips had good targeting to mitochondria of tumor cells, and its target effect on mitochondria of HepG2 was better than that of Huh-7 cells. Compared with CTD, the cytotoxicity of liposomes on HepG2 is 7.0 times higher, while the cytotoxic effect on normal liver cells Thle-2 is 2.1 times lower. It may be related to increasing clathrin-mediated endocytosis, inhibiting tumor cell migration, arresting cell cycle in G1/G0 phase, and promoting mitochondria-mediated endogenous Bcl-2/Caspase 3 apoptosis pathway. Meanwhile, FA/FRFK-CTD/BA-Lips could alter the pharmacokinetic behavior of CTD and BA by increasing concentrations , slowing release and excretion, good anti-tumor with no obvious toxicity, and successfully delivered CTD/BA to liver tissue, tumor cells and mitochondria. Therefore, FA/FRFK-CTD/BA-Lips, as a delivery system targeting the mitochondria of liver cancer cells, has promising development potential, and could provide a new strategy for solving the problem of CTD toxicity and the treatment of hepatocellular carcinoma.","PeriodicalId":8066,"journal":{"name":"Applied Materials Today","volume":"302 1","pages":""},"PeriodicalIF":8.3,"publicationDate":"2024-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141931141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-08-03DOI: 10.1016/j.apmt.2024.102358
Muhammad Husnain Manzoor, Namisa Naz, Syyeda Maimoona Ghayyoor Naqvi, Shumaila Ashraf, Muhammad Zain Ashiq, Francis Verpoort
Water is an indispensable element for all forms of life, constituting a defining characteristic of our planet and the human body. The presence of hazardous contaminants, including emerging contaminants, heavy metal ions, and organic dyes, poses a significant threat to water supplies due to their acute toxicity and carcinogenic properties. Presently, researchers are channeling considerable efforts toward developing novel techniques, improving existing methods, and providing enduring ecologically friendly solutions to address water pollution challenges. Consequently, there is a pressing need to transform wastewater into a valuable water resource, emphasizing the imperative of optimal reuse. Metal-organic frameworks (MOFs) represent intricate structures comprising metal ions or clusters intricately linked by organic connectors, forming one or more dimensions. Numerous MOFs have demonstrated efficacy in wastewater treatment due to their expansive surface area, crystalline structure, substantial pore size, and tunability. This comprehensive review aims to delve into the synthesis, structure, classification, and properties of MOFs. Furthermore, it explores diverse applications and meticulously examines factors influencing adsorption. Finally, a thorough discussion is provided regarding the current challenges and future prospects associated with utilizing MOFs in water treatment processes.
{"title":"Wastewater treatment using Metal-Organic Frameworks (MOFs)","authors":"Muhammad Husnain Manzoor, Namisa Naz, Syyeda Maimoona Ghayyoor Naqvi, Shumaila Ashraf, Muhammad Zain Ashiq, Francis Verpoort","doi":"10.1016/j.apmt.2024.102358","DOIUrl":"https://doi.org/10.1016/j.apmt.2024.102358","url":null,"abstract":"Water is an indispensable element for all forms of life, constituting a defining characteristic of our planet and the human body. The presence of hazardous contaminants, including emerging contaminants, heavy metal ions, and organic dyes, poses a significant threat to water supplies due to their acute toxicity and carcinogenic properties. Presently, researchers are channeling considerable efforts toward developing novel techniques, improving existing methods, and providing enduring ecologically friendly solutions to address water pollution challenges. Consequently, there is a pressing need to transform wastewater into a valuable water resource, emphasizing the imperative of optimal reuse. Metal-organic frameworks (MOFs) represent intricate structures comprising metal ions or clusters intricately linked by organic connectors, forming one or more dimensions. Numerous MOFs have demonstrated efficacy in wastewater treatment due to their expansive surface area, crystalline structure, substantial pore size, and tunability. This comprehensive review aims to delve into the synthesis, structure, classification, and properties of MOFs. Furthermore, it explores diverse applications and meticulously examines factors influencing adsorption. Finally, a thorough discussion is provided regarding the current challenges and future prospects associated with utilizing MOFs in water treatment processes.","PeriodicalId":8066,"journal":{"name":"Applied Materials Today","volume":"27 1","pages":""},"PeriodicalIF":8.3,"publicationDate":"2024-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141931143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
In this groundbreaking study, Polyethylene Terephthalate Glycol (PETG)-FeO nanocomposites were developed for 4D printing, incorporating iron oxide (FeO) nanoparticles into PETG matrix. The research contribution lies in its innovative approach to enhancing the shape memory effect (SME) through thermo-magnetic responsiveness, positioning PETG-FeO as a revolutionary material in smart additive manufacturing. The composites were synthesized using a melt mixing method, followed by 3D printing into specimens for comprehensive evaluation through dynamic mechanical thermal analysis (DMTA), scanning electron microscopy (SEM), and uniaxial tensile tests. The findings revealed that the incorporation of FeO nanoparticles significantly boosts the composites’ storage modulus and glass transition temperature, indicative of improved stiffness and thermal properties. Notably, the 15 % FeO composite emerged as the optimal blend, exhibiting the highest tensile strength and a favourable balance between mechanical integrity and flexibility. A key result was the enhanced SME under both thermal and magnetic stimuli, with recovery efficiency and speed escalating with nanoparticle concentration. This advancement underscores the potential of PETG-FeO nanocomposites in fabricating smart structures capable of environmental adaptability, paving the way for impacts in biomedical, aerospace, and robotic devices. Through this work, a new paradigm in material functionality for 4D printing has been established, demonstrating the viability of magnetic nanoparticle integration for added smart capabilities.
{"title":"4D printing thermo-magneto-responsive PETG-Fe3O4 nanocomposites with enhanced shape memory effects","authors":"Davood Rahmatabadi, Kiandokht Mirasadi, Abbas Bayati, Mahdi Khajepour, Ismaeil Ghasemi, Majid Baniassadi, Karen Abrinia, Mahdi Bodaghi, Mostafa Baghani","doi":"10.1016/j.apmt.2024.102361","DOIUrl":"https://doi.org/10.1016/j.apmt.2024.102361","url":null,"abstract":"In this groundbreaking study, Polyethylene Terephthalate Glycol (PETG)-FeO nanocomposites were developed for 4D printing, incorporating iron oxide (FeO) nanoparticles into PETG matrix. The research contribution lies in its innovative approach to enhancing the shape memory effect (SME) through thermo-magnetic responsiveness, positioning PETG-FeO as a revolutionary material in smart additive manufacturing. The composites were synthesized using a melt mixing method, followed by 3D printing into specimens for comprehensive evaluation through dynamic mechanical thermal analysis (DMTA), scanning electron microscopy (SEM), and uniaxial tensile tests. The findings revealed that the incorporation of FeO nanoparticles significantly boosts the composites’ storage modulus and glass transition temperature, indicative of improved stiffness and thermal properties. Notably, the 15 % FeO composite emerged as the optimal blend, exhibiting the highest tensile strength and a favourable balance between mechanical integrity and flexibility. A key result was the enhanced SME under both thermal and magnetic stimuli, with recovery efficiency and speed escalating with nanoparticle concentration. This advancement underscores the potential of PETG-FeO nanocomposites in fabricating smart structures capable of environmental adaptability, paving the way for impacts in biomedical, aerospace, and robotic devices. Through this work, a new paradigm in material functionality for 4D printing has been established, demonstrating the viability of magnetic nanoparticle integration for added smart capabilities.","PeriodicalId":8066,"journal":{"name":"Applied Materials Today","volume":"17 1","pages":""},"PeriodicalIF":8.3,"publicationDate":"2024-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141931142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-08-02DOI: 10.1016/j.apmt.2024.102370
Yiqun Fu, Zhen Shi, Keyton D. Feller, Michael D. Schulz, Timothy E. Long, Christopher B. Williams
Compared to their unfilled counterparts, elastomeric nanocomposites offer tailorable combinations of properties, including improved mechanical properties, increased durability, and enhanced thermal and electrical conductivity. However, the high viscosity caused by the presence of both the high molecular weight elastomer and the inclusion of fillers complicates additive manufacturing (AM) of elastomeric nanocomposites. This is especially challenging in vat photopolymerization (VP) AM, which requires resins that possess low viscosity (< 10 Pa·s) and exhibit sufficient storage modulus (∼ 10 Pa) when photocured. To address this process limitation, the authors have previously demonstrated decoupling the relationship between viscosity and molecular weight via VP of a photocurable composite latex resin. In this approach, a photocurable matrix is photocured as a scaffold around the latex particles, which provides sufficient modulus for the printed "green" part. Following a dehydration post-processing step, the latex particles coalesce to provide the final elastomeric mechanical properties without compromising feature resolution.
与未填充的同类产品相比，弹性纳米复合材料具有可定制的特性组合，包括更好的机械特性、更高的耐用性以及更强的导热性和导电性。然而，由于高分子量弹性体的存在和填料的加入而导致的高粘度使弹性纳米复合材料的增材制造（AM）变得复杂。这在大桶光聚合 (VP) AM 中尤其具有挑战性，因为 VP AM 要求树脂具有低粘度（< 10 Pa-s），并在光固化时表现出足够的存储模量（∼ 10 Pa）。为了解决这一工艺限制，作者之前通过光固化复合乳胶树脂的 VP，证明了粘度和分子量之间的解耦关系。在这种方法中，光固化基质作为乳胶颗粒周围的支架进行光固化，为印刷的 "绿色 "部件提供足够的模量。经过脱水后处理步骤后，乳胶颗粒凝聚在一起，在不影响特征分辨率的情况下提供最终的弹性机械性能。
{"title":"Vat photopolymerization of silica reinforced styrene-butadiene rubber elastomeric nanocomposites","authors":"Yiqun Fu, Zhen Shi, Keyton D. Feller, Michael D. Schulz, Timothy E. Long, Christopher B. Williams","doi":"10.1016/j.apmt.2024.102370","DOIUrl":"https://doi.org/10.1016/j.apmt.2024.102370","url":null,"abstract":"Compared to their unfilled counterparts, elastomeric nanocomposites offer tailorable combinations of properties, including improved mechanical properties, increased durability, and enhanced thermal and electrical conductivity. However, the high viscosity caused by the presence of both the high molecular weight elastomer and the inclusion of fillers complicates additive manufacturing (AM) of elastomeric nanocomposites. This is especially challenging in vat photopolymerization (VP) AM, which requires resins that possess low viscosity (< 10 Pa·s) and exhibit sufficient storage modulus (∼ 10 Pa) when photocured. To address this process limitation, the authors have previously demonstrated decoupling the relationship between viscosity and molecular weight via VP of a photocurable composite latex resin. In this approach, a photocurable matrix is photocured as a scaffold around the latex particles, which provides sufficient modulus for the printed \"green\" part. Following a dehydration post-processing step, the latex particles coalesce to provide the final elastomeric mechanical properties without compromising feature resolution.","PeriodicalId":8066,"journal":{"name":"Applied Materials Today","volume":"15 Suppl 1 1","pages":""},"PeriodicalIF":8.3,"publicationDate":"2024-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141931144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M1 macrophages play a crucial role in the development of rheumatoid arthritis (RA), which can produce various inflammation cytokines, and reactive oxygen species (ROS). Disulfide bonds as reduction-responsive linkages have been extensively employed in the drug delivery systems. However, disulfide bonds are rarely reported in the development of the oxidation-responsive drug carriers. Herein, we designed and synthetized novel oxidation-responsive drug carriers based on disulfide bonds, and further developed nanoparticles (FA-TP@NPs) by self-assembly for the RA treatment. FA-TP@NPs was decorated with folic acid and loaded with triptolide (TP), a potent anti-inflammation Chinese medicine, to target and enter M1 macrophages through the folate receptor on the cytomembrane for simultaneous repolarization of the M2 macrophage and elimination of the M1 macrophage. As expected, FA-TP@NPs exhibited an oxidation-responsive TP release via disulfide-bond oxidation and ester-bond hydrolysis in the presence of intracellular ROS, which accumulated preferentially in inflamed joints. FA-TP@NPs exerted a potent anti-arthritic effect with high biosafety in CIA mice, as evidenced by repolarizing M2 macrophages, inducing M1 macrophage apoptosis, and reducing TNF-α, IL-6, and IL-1β expression. This work shows that FA-TP@NPs give a deep insight into disulfide bond-based oxidation-responsive drug delivery systems, and provide a potential platform for RA treatment.
M1 巨噬细胞在类风湿性关节炎（RA）的发病过程中起着至关重要的作用，它能产生各种炎症细胞因子和活性氧（ROS）。二硫键作为还原反应性连接体已被广泛应用于给药系统中。然而，二硫键在氧化反应药物载体的开发中却鲜有报道。在此，我们设计并合成了基于二硫键的新型氧化反应药物载体，并通过自组装进一步开发了用于治疗 RA 的纳米颗粒（FA-TP@NPs）。FA-TP@NPs用叶酸装饰，并负载了一种强效抗炎中药--曲托内酯（TP），通过胞膜上的叶酸受体靶向进入M1巨噬细胞，同时使M2巨噬细胞极化并清除M1巨噬细胞。正如预期的那样，FA-TP@NPs 在细胞内 ROS 的存在下，通过二硫键氧化和酯键水解表现出氧化反应性 TP 释放，而 ROS 在发炎的关节中优先积累。FA-TP@NPs在CIA小鼠中发挥了强效的抗关节炎作用，生物安全性高，表现为使M2巨噬细胞恢复极性，诱导M1巨噬细胞凋亡，降低TNF-α、IL-6和IL-1β的表达。这项工作表明，FA-TP@NPs 深入揭示了基于二硫键的氧化反应给药系统，并为治疗 RA 提供了一个潜在的平台。
{"title":"Disulfide bond-based oxidation-responsive triptolide-loaded nanodrug for inflammation-targeted treatment of collagen-induced arthritis","authors":"Huahui Zeng, Man Li, Zhirong Wang, Tianqi Wang, Zhenqiang Zhang, Xiangxiang Wu","doi":"10.1016/j.apmt.2024.102350","DOIUrl":"https://doi.org/10.1016/j.apmt.2024.102350","url":null,"abstract":"M1 macrophages play a crucial role in the development of rheumatoid arthritis (RA), which can produce various inflammation cytokines, and reactive oxygen species (ROS). Disulfide bonds as reduction-responsive linkages have been extensively employed in the drug delivery systems. However, disulfide bonds are rarely reported in the development of the oxidation-responsive drug carriers. Herein, we designed and synthetized novel oxidation-responsive drug carriers based on disulfide bonds, and further developed nanoparticles (FA-TP@NPs) by self-assembly for the RA treatment. FA-TP@NPs was decorated with folic acid and loaded with triptolide (TP), a potent anti-inflammation Chinese medicine, to target and enter M1 macrophages through the folate receptor on the cytomembrane for simultaneous repolarization of the M2 macrophage and elimination of the M1 macrophage. As expected, FA-TP@NPs exhibited an oxidation-responsive TP release via disulfide-bond oxidation and ester-bond hydrolysis in the presence of intracellular ROS, which accumulated preferentially in inflamed joints. FA-TP@NPs exerted a potent anti-arthritic effect with high biosafety in CIA mice, as evidenced by repolarizing M2 macrophages, inducing M1 macrophage apoptosis, and reducing TNF-α, IL-6, and IL-1β expression. This work shows that FA-TP@NPs give a deep insight into disulfide bond-based oxidation-responsive drug delivery systems, and provide a potential platform for RA treatment.","PeriodicalId":8066,"journal":{"name":"Applied Materials Today","volume":"4 1","pages":""},"PeriodicalIF":8.3,"publicationDate":"2024-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141931145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-08-01DOI: 10.1016/j.apmt.2024.102368
Chao Jiang, Zhiwei Jiang, Shuxin Dai, Dengxiong Li, Ruicheng Wu, Jie Wang, Qingxin Yu, Luxia Ye, Fanglin Shao, Zhipeng Wang, Koo Han Yoo, Yubo Yang, Mang Ke, William C. Cho, Wuran Wei, Zhouting Tuo, Dechao Feng
Three-dimensional (3D) printing technology is a new technology based on computer 3D digital imaging and multi-level continuous printing. From the initial field of construction manufacturing, it has gradually developed into the field of biology and medicine. Currently, 3D printing is widely utilized in orthopedics, dentistry, and other medical disciplines, and is gaining increasing attention in tumor radiotherapy. As a key cancer treatment, the trend towards precision and personalization in radiotherapy aligns perfectly with the capabilities of 3D printing. This innovative technology enables the creation of highly personalized treatment plans through the production of patient-specific anatomical models, radiation boluses, and implantable devices. It facilitates accurate visualization of complex tumor geometries, allowing for precise targeting and dose distribution. Additionally, 3D printing enhances the customization of radiotherapy accessories, improving radiation delivery conformity and minimizing exposure to surrounding healthy tissues. This review highlights the current advancements, applications, and future prospects of 3D printing in tumor radiotherapy, emphasizing its potential to enhance treatment efficacy and patient outcomes.
三维（3D）打印技术是一种基于计算机三维数字成像和多层次连续打印的新技术。它从最初的建筑制造领域，逐渐发展到生物和医学领域。目前，3D 打印技术已广泛应用于骨科、牙科等医学领域，并在肿瘤放疗领域日益受到重视。作为一种重要的癌症治疗手段，放疗的精确化和个性化趋势与 3D 打印技术的功能完美契合。这项创新技术通过制作病人专用的解剖模型、放射栓和植入式装置，实现了高度个性化的治疗方案。它有助于对复杂的肿瘤几何形状进行精确的可视化，从而实现精确的靶向和剂量分布。此外，3D 打印还增强了放疗附件的定制能力，提高了放射线输送的一致性，并最大限度地减少了对周围健康组织的照射。本综述重点介绍了3D打印技术在肿瘤放疗中的当前进展、应用和未来前景，强调了它在提高治疗效果和患者预后方面的潜力。
{"title":"The application of 3D printing technology in tumor radiotherapy in the era of precision medicine","authors":"Chao Jiang, Zhiwei Jiang, Shuxin Dai, Dengxiong Li, Ruicheng Wu, Jie Wang, Qingxin Yu, Luxia Ye, Fanglin Shao, Zhipeng Wang, Koo Han Yoo, Yubo Yang, Mang Ke, William C. Cho, Wuran Wei, Zhouting Tuo, Dechao Feng","doi":"10.1016/j.apmt.2024.102368","DOIUrl":"https://doi.org/10.1016/j.apmt.2024.102368","url":null,"abstract":"Three-dimensional (3D) printing technology is a new technology based on computer 3D digital imaging and multi-level continuous printing. From the initial field of construction manufacturing, it has gradually developed into the field of biology and medicine. Currently, 3D printing is widely utilized in orthopedics, dentistry, and other medical disciplines, and is gaining increasing attention in tumor radiotherapy. As a key cancer treatment, the trend towards precision and personalization in radiotherapy aligns perfectly with the capabilities of 3D printing. This innovative technology enables the creation of highly personalized treatment plans through the production of patient-specific anatomical models, radiation boluses, and implantable devices. It facilitates accurate visualization of complex tumor geometries, allowing for precise targeting and dose distribution. Additionally, 3D printing enhances the customization of radiotherapy accessories, improving radiation delivery conformity and minimizing exposure to surrounding healthy tissues. This review highlights the current advancements, applications, and future prospects of 3D printing in tumor radiotherapy, emphasizing its potential to enhance treatment efficacy and patient outcomes.","PeriodicalId":8066,"journal":{"name":"Applied Materials Today","volume":"35 1","pages":""},"PeriodicalIF":8.3,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141931148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-08-01DOI: 10.1016/j.apmt.2024.102369
Le Huy Thai, Le Thi Thanh Nhi, Truong Chau Giang, Nguyen Minh Hiep, Truong Quang Trung, Tran Quang Hung, Le Hoang Sinh
A new 3D printed multicolor Prussian blue-viologen inorganic-organic hybrid electrochromic device was successfully developed using digital light processing. Photocurable 1-(2 cyanophenyl)-1′-(2-hydroxyethyl)-[4,4′-bipyridine]-1,1′-diium (CPHEV)-based ionogel was printed on ITO glass as an electrochromic layer. The thin film of Prussian blue (PB) was electrodeposited on another ITO glass as an ion storage layer. With PB thin film, the ECDs exhibited a bleaching time 330 times faster than that of ECDs without PB. The ECD showed excellent electrochromic performance with a high color contrast ratio of 93.4 % at -2.5 V with a pulse width of 5 s. Moreover, the ECDs also exhibited multi-coloration in L*a*b* color space with the highest different color points (ΔE*) value of 75.2 between the bleaching state and coloring state. A high coloration efficiency of the ECD was obtained at 296 cm C corresponding to 60 % of a full optical switch at -2.5 V. The 3D printed ECD was successfully demonstrated using digital light processing (DLP) with high dimensional accuracy and resolution.
利用数字光处理技术，成功开发出一种新型三维打印多色普鲁士蓝-紫胶无机-有机杂化电致变色装置。光固化的 1-(2-氰基苯基)-1′-(2-羟乙基)-[4,4′-联吡啶]-1,1′-二鎓（CPHEV）离子凝胶被打印在 ITO 玻璃上作为电致变色层。普鲁士蓝（PB）薄膜作为离子存储层被电沉积在另一块 ITO 玻璃上。有了普鲁士蓝薄膜，ECD 的漂白时间比没有普鲁士蓝薄膜的 ECD 快 330 倍。此外，ECD 还在 L*a*b* 色彩空间中表现出多重着色，漂白态和着色态之间的最高不同色点（ΔE*）值为 75.2。在 296 cm C 时，ECD 的着色效率很高，相当于 -2.5 V 时全光开关的 60%。利用数字光处理（DLP）技术成功展示了三维打印的 ECD，具有很高的尺寸精度和分辨率。
{"title":"3D printed multicolor Prussian blue-viologen hybrid electrochromic devices: Toward high contrast ratio and fast switching electrochromic devices","authors":"Le Huy Thai, Le Thi Thanh Nhi, Truong Chau Giang, Nguyen Minh Hiep, Truong Quang Trung, Tran Quang Hung, Le Hoang Sinh","doi":"10.1016/j.apmt.2024.102369","DOIUrl":"https://doi.org/10.1016/j.apmt.2024.102369","url":null,"abstract":"A new 3D printed multicolor Prussian blue-viologen inorganic-organic hybrid electrochromic device was successfully developed using digital light processing. Photocurable 1-(2 cyanophenyl)-1′-(2-hydroxyethyl)-[4,4′-bipyridine]-1,1′-diium (CPHEV)-based ionogel was printed on ITO glass as an electrochromic layer. The thin film of Prussian blue (PB) was electrodeposited on another ITO glass as an ion storage layer. With PB thin film, the ECDs exhibited a bleaching time 330 times faster than that of ECDs without PB. The ECD showed excellent electrochromic performance with a high color contrast ratio of 93.4 % at -2.5 V with a pulse width of 5 s. Moreover, the ECDs also exhibited multi-coloration in L*a*b* color space with the highest different color points (ΔE*) value of 75.2 between the bleaching state and coloring state. A high coloration efficiency of the ECD was obtained at 296 cm C corresponding to 60 % of a full optical switch at -2.5 V. The 3D printed ECD was successfully demonstrated using digital light processing (DLP) with high dimensional accuracy and resolution.","PeriodicalId":8066,"journal":{"name":"Applied Materials Today","volume":"128 1","pages":""},"PeriodicalIF":8.3,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141931147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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